CN116918965A - Food composition capable of correcting vision and application thereof - Google Patents
Food composition capable of correcting vision and application thereof Download PDFInfo
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- CN116918965A CN116918965A CN202310459540.5A CN202310459540A CN116918965A CN 116918965 A CN116918965 A CN 116918965A CN 202310459540 A CN202310459540 A CN 202310459540A CN 116918965 A CN116918965 A CN 116918965A
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- enzymatic hydrolysate
- vision
- food composition
- correcting
- enzymolysis
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/65—Addition of, or treatment with, microorganisms or enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
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- Marine Sciences & Fisheries (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a vision-correcting food composition and application thereof, which is prepared from nostoc sphaeroids kutz enzymatic hydrolysate, cicada enzymatic hydrolysate, cock crown enzymatic hydrolysate, sea cucumber enzymatic hydrolysate, rhizoma polygonati enzymatic hydrolysate, dunaliella salina enzymatic hydrolysate, peach kernel extract and selenium-enriched yeast through enzymatic hydrolysis, extraction and crushing. Can be made into health food such as biscuit, tablet candy, solid beverage, etc., and is suitable for students, myopia patients, drivers, mental workers, and people with hypoimmunity. The invention has good taste, small dosage, convenient carrying, safe administration, wide applicable crowd, good effect and good market prospect and popularization value.
Description
Technical Field
The present invention relates to a food composition capable of correcting vision, and more particularly, to a food composition capable of correcting myopia, amblyopia, astigmatism, asthenopia and improving memory and immunity, and its use.
Background
Myopia, amblyopia, astigmatism and asthenopia are common ophthalmic diseases with extremely high incidence, and it is reported that people suffering from myopia in China reach 6 hundred million people, and the first of the world is known.
The existing external products for treating myopia mainly adopt shaping glasses, physiotherapy instruments, eye patches, massage cream, eyedrops, massage instruments, eye shields and the like, and although the external products can relieve and delay the development of myopia, the external products can not tonify qi and blood, and treat the symptoms and not the root cause. The main raw materials of the blueberry lutein tablet sold in the market are blueberry powder, lutein and auxiliary materials, and the blueberry lutein tablet is formed by tabletting, has single raw materials, can only relieve the deepening of myopia degree, and has poor myopia treatment effect. The composition of nostoc sphaeroids kutz, jasmine, pepper, germ rice and collagen peptide disclosed in CN110403200A only has the effect of relieving eye fatigue. The food composition of sorbitol, maltodextrin, blueberry powder, lutein, carotene, fish oil microcapsule powder and vitamin A disclosed in CN108041609A only plays roles of preventing myopia and improving eye fatigue. CN110326648A discloses that rhizoma Polygonati is used as a raw material for making biscuits, and only enriches the using method of rhizoma Polygonati. The product does not contain components for tonifying qi and blood, promoting blood circulation and removing blood stasis, and the like, so that the product has no effects of correcting myopia, amblyopia, astigmatism, improving memory and the like.
Teenagers all like to eat baked foods such as biscuits, bread, cakes and the like, but the baked foods sold in the market only solve the problems of appearance and taste, and do not have the functions of improving eyesight, improving memory and improving immunity.
Disclosure of Invention
According to the ' myopia-capable person who cannot get far sighted ' and the ' blood deficiency and qi deficiency ' of the ' Sun Simiao ' eye-protection famous ' of the medicine king, the invention absorbs the essence for treating myopia at home and abroad, and provides a food composition capable of correcting vision so as to make up the defects of the prior art.
The vision-correcting food composition is characterized by being prepared from the following components in parts by weight: 10-40 parts of nostoc sphaeroids kutz enzymatic hydrolysate, 10-40 parts of cock crown enzymatic hydrolysate, 10-15 parts of golden cicada enzymatic hydrolysate, 5-10 parts of sea cucumber enzymatic hydrolysate, 2-5 parts of rhizoma polygonati enzymatic hydrolysate, 10-40 parts of dunaliella salina enzymatic hydrolysate, 2-5 parts of peach kernel extract and 1-3 parts of selenium-enriched yeast powder.
The preparation process of the vision-correcting food composition comprises the following steps:
a. preparation of nostoc sphaeroids kutz zymolyte
Washing and crushing nostoc sphaeroids kutz, adding distilled water 70-80 times the mass of the nostoc sphaeroids kutz, decocting for 10 minutes, cooling to 40-50 ℃, regulating the pH value to 5.0 by phosphoric acid, adding protein pectin cellulose mixed enzyme for enzymolysis, and placing the enzymolysis material into supercritical CO after 2-4 hours of enzymolysis 2 CO is used for extracting at 31-39 ℃ and 7-10 MPa under supercritical state in an extraction device 2 Extracting for 60 min, and closing CO 2 Air inlet valve, after decompression and temperature rising, supercritical CO 2 The fluid becoming gaseous CO 2 Recovery of CO 2
Then the extracted enzymatic extract of nostoc sphaeroids kutz is completely or basically separated out, the extracted enzymatic extract is put into a freeze dryer for drying at the temperature of minus 20 ℃ to 40 ℃ for 48 to 72 hours, the dried nostoc sphaeroids kutz enzymatic hydrolysate is crushed to more than 500 meshes by a vibration wall breaking machine at the temperature of minus 15 ℃ to minus 30 ℃ to prepare dry powder of nostoc sphaeroids kutz enzymatic hydrolysate for standby, the protein pectin cellulose mixed enzyme consists of papain, pectase and cellulase, the mass ratio of the papain, the pectase and the cellulase is 1:2:2, and the mass ratio of the nostoc sphaeroids kutz to the protein pectin cellulose mixed enzyme is 1000:3;
b. preparation of cock crown enzymatic hydrolysate
Washing and mincing the cock crown, adding distilled water with the mass of 2-3 times, decocting for 10 minutes, removing grease on the decoction, cooling to 40-50 ℃, regulating the pH value to 5.0 by phosphoric acid, pouring into a stainless steel fermentation tank, adding glass uronic acid enzyme for enzymolysis, adding distilled water with the mass of 1-5 times into the enzymolysis solution after 2-4 hours of enzymolysis, adding diatomite into the dilution solution with the mass of 1-5 g per Kg of dilution solution, uniformly stirring, vacuum-filtering or high-speed centrifugal separation to collect enzymolysis supernatant, adding chlorohexadecyl or bromohexadecyl pyridine or ammonium sulfate into the enzymolysis supernatant with the mass of 5-15 g per Kg of enzymolysis supernatant, stirring, standing, collecting precipitate, adding 0.8M sodium chloride aqueous solution with the mass of 2-3 times, then stirring and dissociating, centrifuging for 10 minutes by a centrifuge, removing precipitate, collecting the dissociation solution with the mass of 1-5 g per Kg of dissociation solution, adding the dissociation solution into the chicken crown with the mass of 1-5 g of dissociation solution, stirring, drying the enzymolysis solution with the mass of-5 g of dry chicken crown under the conditions of 5-95% of dry, and drying the dry powder after the dry enzymolysis solution is dried, and the dry enzymolysis solution is dried after the dry, and the dry enzymolysis solution is dried to be dried and subjected to the dry, and the dry ratio of the dry solution is subjected to the dry shaking of 1-500-1000% to the dry filter, and the dry filter is prepared after the dry filter is subjected to the dry and the dry filter is subjected to the dry filter is subjected to the dry filtration;
c. preparation of cicada zymolyte
Cleaning and crushing golden cicada, adding distilled water with the mass ratio of 5 times, decocting for 10 minutes, cooling to 40-50 ℃, adding papain pectin mixed enzyme with the mass ratio of 1:1, uniformly mixing, pouring into a fermentation tank, regulating the pH value to 5.0 by phosphoric acid, carrying out enzymolysis at the temperature of 40-50 ℃ for 2-4 hours, putting the golden cicada enzymatic hydrolysate into a freeze dryer, drying at the temperature of-20-40 ℃ for 48-72 hours, and vibrating and breaking the wall of the dried product at the temperature of-15 to-30 ℃ to obtain golden cicada enzymatic hydrolysate dry powder with the mass ratio of more than 500 meshes for later use, wherein the papain pectin mixed enzyme consists of papain and pectase, the mass ratio of papain to pectase is 1:1, and the mass ratio of golden cicada to papain pectin composite enzyme is 1000:1;
d. sea cucumber zymolyte preparation
Soaking dried sea cucumber in water for 20-24 h, removing viscera and body cavity membrane, mincing, adding distilled water with the mass of 5 times, decocting for 10min, cooling to 40-50 ℃, regulating the pH value to 5.0 by lactic acid, adding papain for enzymolysis, drying the dried sea cucumber zymolyte at-20-40 ℃ for 48-72 h after enzymolysis for 2-4 h, and crushing the dried sea cucumber zymolyte to more than 500 meshes at-15-30 ℃ to obtain dried sea cucumber zymolyte powder for later use, wherein the mass ratio of the dried sea cucumber zymolyte to the papain is 1000:1;
e. preparation of rhizoma polygonati enzymolysis product
Cleaning rhizoma Polygonati, steaming for 2 hr, sun drying, and repeating the stepsCrushing to 80 meshes after secondary steaming and sun drying, adding distilled water with the mass of 20 times, adding fiber pectin mixed enzyme, performing enzymolysis at 40 ℃ for 1 hour, and using CO to perform enzymolysis at 31-39 ℃ and 7-10 MPa 2 Extracting for 60 minutes, drying the extracted rhizoma polygonati enzymatic hydrolysate at the temperature of-20-40 ℃ for 48-72 hours, and crushing to more than 500 meshes to prepare rhizoma polygonati enzymatic hydrolysis dry powder for later use, wherein the fiber pectin mixed enzyme consists of cellulase and pectase, the mass ratio of the cellulase to the pectase is 1:1, and the mass ratio of the rhizoma polygonati dry product to the fiber pectin mixed enzyme is 1000:15;
f. preparation of dunaliella salina zymolyte
Washing and crushing a brine alga dry product, adding distilled water with the mass of 8 times, decocting for 10 minutes, cooling to 40-50 ℃, adjusting the pH value to 5.0, sequentially adding papain and pectase for enzymolysis, and carrying out enzymolysis for 2-4 hours, wherein the brine alga enzymolysis material is subjected to CO under the supercritical state at 31-39 ℃ and 7-10 MPa 2 Extracting for 60 minutes, then decompressing and heating, drying the extracted brine alga enzymolysis extract at the temperature of between 20 ℃ below zero and 40 ℃ for 48 to 72 hours, and crushing the dried extract at the temperature of between 15 ℃ below zero and 30 ℃ below zero into dry brine alga enzymolysis extract powder with the mass ratio of more than 500 meshes to prepare brine alga enzymolysis extract powder for standby, wherein the mass ratio of the brine alga dry extract to papain to pectase is 1000:1:0.3;
g. preparation of semen Persicae extract
Washing peach kernels, removing tip skin, stir-frying, adding distilled water with the mass of 2 times, mixing, extracting at the temperature of 31-39 ℃ and the pressure of 7-10 MPa for 1-2 hours, drying the extracted peach kernel extract at the temperature of minus 20-40 ℃ for 48-72 hours, and crushing to more than 500 meshes at the temperature of minus 15-minus 30 ℃ to prepare dry peach kernel extract powder for later use;
h. pulverizing commercially available selenium-enriched yeast to above 500 meshes at-15 to-30 ℃ for standby;
i. the nostoc sphaeroids kutz zymolyte dry powder, the cock crown zymolyte dry powder, the golden cicada zymolyte dry powder, the sea cucumber zymolyte dry powder, the rhizoma polygonati zymolyte dry powder, the salt algae zymolyte dry powder, the peach kernel extract dry powder and the selenium-enriched yeast powder are uniformly mixed according to a conventional process to prepare the food composition capable of correcting eyesight.
The use of the vision-correcting food composition is characterized in that the vision-correcting food composition prepared by the method is mixed with flour in an amount of 10-30% of the flour by mass to prepare biscuits.
The use of the vision-correcting food composition is characterized in that the vision-correcting food composition is mixed with powdered sugar in a mass ratio of 5-20:1 to prepare a tabletted candy.
The vision-correcting food composition is used for preparing solid beverage by mixing the vision-correcting food composition with powdered sugar and fruit powder or milk powder in the mass ratio of 7-8:1-2:1.
The vision-correcting food composition is used for preparing health care capsule food by mixing the vision-correcting food composition with starch in a mass ratio of 9-18:1 and then encapsulating.
CO of the invention 2 The supercritical extraction equipment is produced by Jiangsu Gaokao pharmaceutical equipment Co., ltd 2 The extraction can effectively prevent the oxidation and dissipation of heat-sensitive substances, and can extract substances with high boiling point, low volatility and easy pyrolysis below the boiling point temperature. Because the whole process does not use organic solvent, the extract has no solvent residue, and simultaneously, the toxicity to human body and the pollution to the environment in the extraction process can be prevented. When saturated with dissolved CO 2 The SCF, when flowing through the separator, causes CO due to pressure drop 2 The extraction liquid is separated from the extract rapidly in a gas-liquid phase, so that the extraction efficiency is high, the energy consumption is low, and the cost is saved.
The freeze dryer is produced by a large energy-saving boiler manufacturer in China in Shandong province, and the freeze drying is basically carried out at the temperature below 0 ℃, namely, the product is raised to the temperature above 0 ℃ only when the residual water content of the product is reduced in the later period, but the temperature is not higher than 40 ℃, so that the loss of volatile components and the oxidative denaturation or inactivation of some heat-sensitive substances caused by the powder spraying drying method carried out at the temperature above 100 ℃ or higher are avoided.
The selenium-enriched yeast is a food nutrition enhancer approved by national institute of health and Commission, and is produced by Angel Yeast Co., ltd, wherein the selenium content is 2000ppm/Kg.
The low-temperature vibration wall breaking machine is produced by Shandong Jinan jun mechanical equipment limited company, and the equipment is provided with a refrigerator, is totally closed, and is crushed at a low temperature of-15 to-30 ℃ so as to reduce the loss of effective substances.
All of the 'materia medica outline mu Lesion' and 'drug property test' and 'national Chinese herbal medicine assembly' record that nostoc sphaeroids kutz has the effects of improving eyesight, tonifying qi, treating night blindness, relieving fever, clearing heat, prolonging life, relieving fatigue and the like. The dry matter total protein of nostoc sphaeroids kutz reaches about 48 to 56 percent, contains 18 amino acids, chlorophyll 30.98mg/g, ascorbic acid 5.50mg/g, vitamin B26.3 ppm and vitamin E5.8ppm. The vitamin C content is more than 5 times higher than that of hawthorn and 5 times higher than that of citrus; vitamins B1 and B2 are higher than those of general bacteria algae; nostoc contains 15 minerals, such as: calcium, iron, zinc, copper, selenium and the like, wherein the calcium content of the nostoc sphaeroids kutz is higher than that of common vegetables, the calcium content of dried nostoc sphaeroids kutz is 406mg per hundred grams, the nostoc sphaeroids kutz contains 290mg, and the iron content of the nostoc sphaeroids kutz is 2 times higher than that of the agaric, so the nostoc sphaeroids kutz is very beneficial to iron supplementing and blood nourishing of human bodies, and is an excellent natural nutritional food. The cell wall of nostoc sphaeroids kutz has two layers, the inner layer is mainly provided with pectin and cellulose, the chemical components of the outer colloid sheath are mainly pectin and pentosan, and the cell structure of nostoc sphaeroids kutz limits the absorption and utilization of people to the nutrients. Through enzymolysis, extraction and wall breaking of nostoc sphaeroids kutz, the nutrition is higher and the absorption is better.
Before 38 hundred million years, brine alga is the oldest single-cell organism on the earth, can survive in the summer at 53 ℃ and reproduce under the severe cold at-27 ℃, and can kill bacteria by 0.9% of saline water, but can survive in 96% of saline water. The brine alga is rich in various natural carotenoids, lutein, zeaxanthin, folic acid, vitamin A, vitamin E, linolenic acid, linoleic acid, lecithin, brine alga polysaccharide and the like, also contains more than 70 minerals and microelements required by human bodies such as calcium, iron, zinc, selenium and the like, and is also rich in 18 amino acids, which are all essences required by eyes and are known as protecting agents for protecting spirit and life of cells by the world scientific community, and the brine alga can comprehensively supplement cell nutrients, remove free radicals, regulate acid-base balance, prevent xerophthalmia, improve eyesight, improve immunity and assist in treating liver diseases and cardiovascular and cerebrovascular diseases.
The cockscomb is a meat-like bulge of the head of a cock, and contains abundant hyaluronic acid (also called hyaluronic acid) with the content of 7.5mg/g, which is higher than that of human umbilical cord, bull's eye, pig's eye and sheep's eye. The male cockscomb also contains nutritional ingredients such as collagen, vitamin E and the like, can prevent eyes from being dry, and has the effects of maintaining beauty and keeping young.
The cicada is also called cicada monkey, known monkey and cicada tortoise, and is a delicious food. The protein content of the cicada is up to more than 70%, and the vitamins and various beneficial trace elements are higher than those of common meat food, which can be called as protein king in the current food. According to the records of Chinese medicinal science, the golden cicada has the functions of replenishing vital essence and strengthening yang, quenching thirst and promoting the production of body fluid, protecting lung and tonifying kidney, treating alopecia and inhibiting diseases and the like. Jin Chanpi it has effects of dispelling pathogenic wind and heat, promoting eruption, relieving sore throat, improving eyesight, removing nebula, dispelling pathogenic wind, and relieving spasm.
"Shenxianzhicao Jing" records: rhizoma Polygonati has effects of regulating stomach and spleen, invigorating qi, regulating viscera, and replenishing muscle, and has the advantages of firm bone marrow, aging, clear color, blushing and blackening teeth, and promoting regeneration of teeth. In Chinese traditional medicine, rhizoma Polygonati is often used for qi deficiency of spleen and stomach, lung deficiency, dry cough, essence and blood deficiency, dizziness, poor appetite, soreness of waist and knees, etc. Modern medical research has demonstrated that: rhizoma Polygonati is rich in polysaccharide, flavone, alkaloid, amino acid, etc., and has antiviral, antiinflammatory, immunity regulating, blood lipid regulating, blood sugar regulating, antidepressant, antiaging, myocardial cell protecting, antitumor, and memory improving effects.
Description of Ben Cao gang mu Miao (compendium of materia Medica): stichopus japonicus is called sea cucumber because it nourishes the stomach and feet. The sea cucumber has remarkable functions of generating blood, nourishing blood and enriching blood. The sea cucumber protein content is 50-80%, and the sea cucumber protein contains rich arginine (617 mg/100 g), glycine, glutamic acid, taurine, calcium, phosphorus, selenium, iron, zinc and various components such as VA, VB1, VB2, VB6, VD, VE, VK7 and the like, can enhance the metabolic function of tissues, enhance the activity of organism cells, eliminate fatigue, improve the immunity of a human body and enhance the disease resistance of the human body. The sea cucumber has strong self-repairing capability and regeneration capability, can repair damaged cells, contains EPA and DHA, and has remarkable benefits for enhancing memory and intelligence quotient. Researchers in the university of newcastle in australia find that arginine and endogenous enzymes of human bodies synthesize nitric oxide, which not only can inhibit the development of myopia, but also can reverse myopia.
The Chinese patent drug Shennong Ben Cao Jing (Shennong's herbal medicine meridian) records that peach kernel has the effects of activating blood, removing stasis, relaxing bowel, relieving cough and asthma, etc. Modern medical research has considered that: the semen Persicae has effects of nourishing and protecting nerve, preventing and treating brain degenerative disease, improving learning and memory capacity, enhancing immunity, protecting cardiovascular and cerebrovascular, reducing blood viscosity, eliminating capillary blood stasis, and improving blood circulation.
The selenium-enriched yeast is the best source for supplementing selenium at present, and compared with inorganic selenium, selenium-enriched tea and the like, the selenium-enriched yeast has stable and rich selenium content, no side effect and high absorption and utilization rate. The physiological effect of selenium is mainly exerted by selenoprotein, and has remarkable effect on antioxidation and human immunity enhancement. Selenium has been shown to be directly or indirectly associated with more than 40 diseases, particularly cancer, cardiovascular disease, diabetes, liver disease, stomach disease, lung disease, ophthalmic disease, endemic disease, etc., and the medical community designates selenium as "anticancer king". The visual acuity of the eagle eye is high, namely, the eagle eye has high selenium content, the retina of the eagle eye has 700-800 mug of selenium, and the selenium content of the human eye is only 7 mug. In the process of generating and developing myopia, the selenium content of retina is continuously reduced, so that blindness is caused. The experimental report suggests that: the pathology of myopia is associated with the trace element selenium. The protein content in the dry yeast can reach 40% -50%, the essential amino acid content is rich, the proportion is reasonable, the yeast is an excellent B-group vitamin source, and the B-group vitamin has the function of nourishing the optic nerve.
The invention has the technical progress that: (1) the invention is described in the medicine king ' Sun Siportal ' of the eye famous ' Yinhai essence: "can myopia, can not far-sighted person, what is too, blood deficiency and qi deficiency. The sea cucumber is used for replenishing blood, the rhizoma polygonati and the nostoc sphaeroids are used for tonifying qi, and qi and blood can be both tonifying; is prepared from nostoc sphaeroids kutz, cockscomb and cicadaThe brine alga, selenium-enriched yeast, sea cucumber and the like, and various nutrients contained in the brine alga can supplement various amino acids, various trace elements, various vitamins, hyaluronic acid, carotene and the like for human bodies; the peach kernel is used for promoting blood circulation to remove blood stasis, eliminating blood vessel blockage, improving eye microcirculation and enabling nutrition to be conveyed to eye tissues; the damaged low-energy cells can be repaired by utilizing the powerful cytoprotection and repair capacities of sea cucumbers, brine alga, selenium-enriched yeast and the like, the abnormal remodeling of the scleral collagen of the eye is changed, and free radicals in the eye are removed; the composition can eliminate the hypoxia of the eye and the sclera, can gradually return the elongated eye shaft to the normal state, can prevent and correct myopia, amblyopia, astigmatism and asthenopia, and has the effects of improving immunity and improving memory (rhizoma polygonati, peach kernel, brine alga, sea cucumber and the like, have the functions of improving memory and improving immunity); the invention can supplement qi and blood, supplement lutein, zeaxanthin, salinomycin, beta carotene, various vitamins, calcium, selenium, zinc and other microelements, arginine, lysine and other amino acids, sea cucumber polysaccharide, hyaluronic acid and other beneficial components, provide sufficient nutrition for eyes and brains, have the effects of preventing and correcting myopia, amblyopia, astigmatism and asthenopia, improving memory and immunity, and are suitable for students, myopic patients and drivers, brain workers, and people with easy cold and low immunity. (2) After biological enzymolysis, cellulose, hemicellulose, pectin and starch in the raw materials are converted into polysaccharide, and crude protein in the raw materials is converted into amino acid, so that the nutrition is higher; due to the adoption of supercritical CO 2 The extract is concentrated, the essence is extracted, the efficacy is higher, and the dosage is smaller; the low-temperature crushing at the temperature of minus 15 ℃ is adopted, the nutrition and the drug effect of the raw materials are not lost, and macromolecular substances are changed into micromolecular substances which are easier to be absorbed by users. (3) The raw material components of the invention are national approved medicine and food homologous foods and food nutrition enhancers, and the invention is safer to take. (4) The invention has wide application, can be made into health foods such as biscuits, pressed candies, solid beverages, baked foods, instant foods and the like, has good taste, good effect, small dosage, convenient carrying and wide applicable crowd, and can lead students to enjoy delicious foods and improve eyesight and memory at the same timeAnd improving immunity.
Detailed Description
The invention is further described below in connection with specific examples.
Example 1:
a. preparation of nostoc sphaeroids kutz zymolyte
Taking 100Kg of nostoc sphaeroids kutz dry product, cleaning, crushing, adding 8000Kg of distilled water, decocting for 10 minutes, cooling to 40-50 ℃, regulating the pH value to 5.0 by phosphoric acid, pouring into a stainless steel fermentation tank, sequentially adding 100g of papain (activity value 300 ten thousand units/g), 100g of pectase and 100g of cellulase to form protein pectin cellulose mixed enzyme, carrying out enzymolysis, and placing the nostoc sphaeroids kutz enzymolysis material into supercritical CO after 2-4 hours of enzymolysis 2 In the extraction device, a carbon dioxide valve is opened for aeration, extraction is carried out at the extraction temperature of 31-39 ℃ and the pressure of 7-10 MPa, and CO 2 At this temperature and pressure, CO is formed into a supercritical state 2 Supercritical fluid, extracting for 60 min, and turning off CO 2 Air inlet valve, after decompression and temperature rising, supercritical CO 2 The fluid becoming gaseous CO 2 Recovery of CO 2 Then the extract nostoc sphaeroids kutz enzymatic hydrolysis extract is completely or basically separated out, then the extracted nostoc sphaeroids kutz enzymatic hydrolysis extract is put into a freeze dryer, dried at the temperature of between 20 ℃ below zero and 40 ℃ below zero for 48 to 72 hours, and the dried nostoc sphaeroids kutz enzymatic hydrolysis extract is crushed to more than 500 meshes by a vibration wall breaking machine at the temperature of between 15 ℃ below zero and 30 ℃ below zero to prepare nostoc sphaeroids kutz enzymatic hydrolysis extract dry powder for standby;
b. preparation of cock crown enzymatic hydrolysate
Taking 100Kg of frozen male cockscomb (or fresh male cockscomb), thawing, cleaning, mincing, adding 200Kg of distilled water, decocting for 10 minutes, removing grease on the surface of decoction, cooling the decoction to 40-50 ℃, regulating the pH value of the decoction to 5.0 by phosphoric acid, pouring into a stainless steel fermentation tank, adding 100g of hyaluronidase for enzymolysis, adding 500Kg of distilled water into the enzymolysis liquid for dilution after 2-4 hours, adding diatomite into the dilution with the amount of 1-5 g of dilution per Kg, stirring uniformly, vacuum-filtering or high-speed centrifugal separation to remove diatomite, collecting clarified enzymolysis supernatant, adding chlorohexadecyl or bromohexadecyl pyridine or ammonium sulfate into the enzymolysis supernatant with the amount of 5-15 g of enzymolysis supernatant per Kg, stirring, standing, removing supernatant, collecting precipitate, adding 2-3 times of 0.8M sodium chloride aqueous solution into the precipitate, stirring and dissociating, dissociating for 30-40 min, centrifuging for 10min by using a centrifuge, removing precipitate, collecting dissociated liquid, adding diatomite into dissociated solution at the dosage of 1-5 g per Kg dissociated liquid, stirring for 1-3 h, vacuum filtering or high-speed centrifugal separation, collecting supernatant, adding 1-5 times of 95% ethanol into the supernatant, stirring, standing, filtering, collecting enzymolysis precipitate, dehydrating and drying the enzymolysis precipitate for 48-72 h, and crushing the dried product into dry powder of the male chicken crown enzymolysis product (main component hyaluronic acid) at the temperature of-15 to-30 ℃ by using a vibration wall breaking machine to prepare dry powder of the male chicken crown enzymolysis product for later use (main component hyaluronic acid);
c. preparation of cicada zymolyte
Thawing 100Kg frozen golden cicada (or fresh golden cicada), cleaning, crushing, adding 500Kg distilled water, decocting for 10 minutes, cooling to 40-50 ℃, adding mixed enzyme consisting of 50g papain and 50g pectase, uniformly mixing, pouring into a fermentation tank, regulating the pH value to 5.0-6.5 by phosphoric acid, controlling the temperature to be 40-50 ℃ for enzymolysis, placing golden cicada enzymatic hydrolysate into a freeze dryer after 2-4 hours of enzymolysis, drying at-20-40 ℃ for 48-72 hours, crushing golden cicada enzymatic hydrolysate into golden cicada enzymatic hydrolysate dry powder with a vibration wall breaking machine at-15 to-30 ℃ to more than 500 meshes, and obtaining golden cicada enzymatic hydrolysate dry powder for standby, wherein Jin Chanpi is thick, not easy to digest, not easy to remove skin, not only can keep the efficacy of cicada skin, but also is easier to be absorbed by human body and has better taste through enzymolysis and superfine crushing;
d. sea cucumber zymolyte preparation
Soaking 100Kg of dried sea cucumber in distilled water for 20-24 h, removing viscera and body cavity membranes, changing water for at least 2 times during the soaking, mincing with a meat mincer, adding 500Kg of distilled water, decocting for 10 minutes, cooling to 40-50 ℃, adjusting pH to 5.0 with lactic acid, pouring into a stainless steel fermentation tank, adding 100g of papain with activity value of 300 ten thousand units/g for enzymolysis for 2-4 h, placing sea cucumber zymolyte into a freeze dryer for drying at-20-40 ℃ for 48-72 h, and crushing the zymolyte into dry sea cucumber zymolyte powder with more than 500 meshes at-15-30 ℃ by using a vibration wall breaking machine for later use;
e. preparation of rhizoma polygonati enzymolysis product
Cleaning 100Kg dry rhizoma Polygonati, steaming in a steamer for 2 hr, taking out, sun drying, repeatedly steaming and sun drying for 9 times in the same step, crushing to 80 mesh, adding 2000Kg distilled water, sequentially adding 750g cellulase and 750g pectase, mixing, pouring into a fermentation tank, regulating pH to 4-5 with lactic acid, performing enzymolysis at 40-50deg.C for 2-4 hr, and adding supercritical CO into rhizoma Polygonati enzymolysis material 2 Extracting in an extraction device, and opening CO 2 Valve inflation, extraction temperature of 31-39 ℃, pressure of 7-10 MPa and CO 2 At this temperature and pressure, CO is formed into a supercritical state 2 Supercritical fluid, extracting for 60 min, and turning off CO 2 Air inlet valve, after decompression and temperature rising, supercritical CO 2 The fluid becoming gaseous CO 2 Recovery of CO 2 Then the extracted rhizoma polygonati enzymolysis extract is completely or basically separated out, and then the extracted rhizoma polygonati enzymolysis extract is put into a freeze dryer for drying at the temperature of between 20 ℃ below zero and 40 ℃ below zero for 48 to 72 hours, and is crushed to more than 500 meshes by a vibration wall breaking machine at the temperature of between 15 ℃ below zero and 30 ℃ below zero to prepare rhizoma polygonati enzymolysis dry powder for later use;
f. preparation of dunaliella salina zymolyte
Washing 100kg of brine alga dry product, crushing, adding 800kg of distilled water for decoction, cooling to 40-50 ℃ after 10 minutes of decoction, regulating the pH value to 5.0 by phosphoric acid, pouring into a stainless steel fermentation tank, sequentially adding 100g of papain with the activity value of 300 ten thousand units/g and 30g of pectase for enzymolysis, and placing brine alga enzymolysis materials into supercritical CO after 2-4 hours of enzymolysis 2 In the extraction device, a carbon dioxide valve is opened for aeration, extraction is carried out at the extraction temperature of 31-39 ℃ and the pressure of 7-10 MPa, and CO 2 At this temperature and pressure, CO is formed into a supercritical state 2 Supercritical fluid, extracting for 60 min, and turning off CO 2 Air inlet valve, after decompression and temperature rising, supercritical CO 2 The fluid becoming gaseous CO 2 Recovery of CO 2 Then the brine alga enzymolysis extract is completely or basically separated out, then the extracted brine alga enzymolysis extract is put into a freeze dryer for drying at the temperature of minus 20 ℃ to 40 ℃ for 48 to 72 hours, and the dried product is crushed by a vibration wall breaking machine at the temperature of minus 15 ℃ to minus 30 ℃ for more than 500 meshes to prepare brine alga enzymolysis dry powder for later use;
g. preparation of semen Persicae extract
Cleaning 100kg semen Persicae, removing bark, parching, adding 200kg distilled water, mixing, and adding supercritical CO 2 In the extraction device, CO is turned on 2 Valve aeration, extraction at 31-39 deg.C and 7-10 MPa, CO 2 At this temperature and pressure, CO is formed into a supercritical state 2 Supercritical fluid, extracting for 1-2 hr, and closing CO 2 Air inlet valve, after decompression and temperature rising, supercritical CO 2 The fluid becoming gaseous CO 2 Recovery of CO 2 Then, the extracted peach kernel extract is completely or basically separated out, and then the extracted peach kernel extract is put into a freeze dryer for drying at the temperature of between 20 ℃ below zero and 40 ℃ below zero for 48 to 72 hours, and the dried material is crushed to more than 500 meshes by a vibration wall breaking machine at the temperature of between 15 ℃ below zero and 30 ℃ below zero to prepare dry peach kernel extract powder for later use;
h. crushing 100kg of commercial selenium-enriched yeast to more than 500 meshes at the temperature of minus 15 ℃ to minus 30 ℃ by using a vibration wall breaking machine for standby;
i. taking 10kg of nostoc sphaeroids kutz zymolyte dry powder, 40kg of cock crown zymolyte dry powder, 10kg of golden cicada zymolyte dry powder, 5kg of sea cucumber zymolyte dry powder, 2kg of rhizoma polygonati zymolyte dry powder, 30kg of salt algae zymolyte dry powder, 2kg of peach kernel extract dry powder and 1kg of selenium-enriched yeast powder, adding proper auxiliaries (maltodextrin, magnesium stearate, sorbitol, sugar, microcrystalline cellulose, fruit powder, potassium sorbate and the like) according to a conventional process, and uniformly mixing to obtain the vision-correcting food composition; or the vision-correcting food composition and powdered sugar are mixed according to the mass ratio of 5-20:1 and then pressed into a vision-correcting tablet candy (a swallow tablet); or the food composition is mixed in flour in an amount of 10 to 30 percent of the flour by weight, and then the biscuit capable of correcting vision is prepared according to the conventional process.
Example 2: the difference between the embodiment and the embodiment 1 is that 20kg of the obtained nostoc sphaeroids kutz enzymatic hydrolysate dry powder, 10kg of the cock crown enzymatic hydrolysate dry powder, 10kg of the golden cicada enzymatic hydrolysate dry powder, 10kg of the sea cucumber enzymatic hydrolysate dry powder, 5kg of the rhizoma polygonati enzymatic hydrolysate dry powder, 40kg of the brine alga enzymatic hydrolysate dry powder, 3kg of the peach kernel extract dry powder, 2kgg selenium-enriched yeast powder and 10kg of corn starch are uniformly mixed and then encapsulated to prepare the vision-correcting health-care capsule food; or the food composition is mixed in flour in an amount of 10 to 30 percent of the flour by weight, and then the biscuit capable of correcting vision is prepared according to the conventional process.
Example 3: the difference between the embodiment and the embodiment 1 is that 30kg of the obtained nostoc sphaeroids kutz zymolyte dry powder, 15kg of the cock crown zymolyte dry powder, 15kg of the golden cicada zymolyte dry powder, 6kg of sea cucumber zymolyte dry powder, 3kg of the rhizoma polygonati zymolyte dry powder, 25kg of the salt algae zymolyte dry powder, 4kg of the peach kernel extract dry powder and 2kg of selenium-enriched yeast powder are uniformly mixed, and then the mixture is prepared into watered pill food capable of correcting eyesight according to the conventional process, and the watered pill food is obtained through drying, packaging and cobalt 60 sterilization; or the vision-correcting food composition is mixed with sugar powder and fruit powder (or milk powder) in the mass ratio of 7-8:1-2:1 to prepare the vision-correcting solid beverage.
Example 4: the embodiment is different from embodiment 1 in that 35kg of the prepared nostoc sphaeroids kutz enzymolysis dry powder, 20kg of the cock crown enzymolysis dry powder, 10kg of the golden cicada enzymolysis dry powder, 5kg of the sea cucumber enzymolysis dry powder, 5kg of the rhizoma polygonati enzymolysis dry powder, 20kg of the brine alga enzymolysis dry powder, 2kg of the peach kernel extract dry powder and 2kg of the selenium-enriched yeast powder are uniformly mixed, and the mixture is mixed in flour with the amount of 10-30% of the flour mass to prepare biscuits capable of correcting eyesight according to the conventional process; or adding adjuvants such as sugar and fruit powder into the food composition according to conventional process, and making into food granule for correcting vision.
Example 5: the difference between this example and example 1 is that 25kg of nostoc sphaeroids kutz enzymatic hydrolysate dry powder, 35kg of cock crown enzymatic hydrolysate dry powder, 10kg of golden cicada enzymatic hydrolysate dry powder, 10kg of sea cucumber enzymatic hydrolysate dry powder, 4kg of rhizoma polygonati enzymatic hydrolysate dry powder, 11kg of brine alga enzymatic hydrolysate dry powder, 2kg of peach kernel extract dry powder and 3kg of selenium-enriched yeast powder are uniformly mixed, and the food composition is mixed in flour in an amount of 10% -30% of the flour mass, and then the cake capable of correcting eyesight is prepared according to the conventional process.
Acute toxicity test of the invention:
1. experimental materials:
sample of pressed candy prepared in example 1 of the present invention, lot number: 20220201, 150 Kunming mice are selected, 75 mice are selected from the male and female animals, and each weight is 18-21 g.
2. The test method comprises the following steps:
(1) and (3) product treatment: the tabletted confectionery product of example 1 of the present invention was prepared as a 24% strength by mass suspension with distilled water and filled. The tabletted candy product of example 1 was further decocted with distilled water for 0.5 hours, centrifuged and filtered, and the precipitate was treated with distilled water again as described above, and the two decoctions were combined to prepare a water decoction containing 60% by mass of the tabletted candy product of example 1 for intraperitoneal injection.
(2) Oral trial, failed to suggest lethal dose in mice: 50 mice with weights of 18-21 g are taken, the male-female proportion is 1:1, each of the mice is filled with a suspension liquid with the concentration of 24%, the reaction of each of the mice is carefully observed after the mice are filled with the liquid, the death number within 30 days is recorded, after the mice are filled with the liquid, the weight of each of the mice is increased, the mice are normal in diet, no obvious toxic or side effect is seen, 50 mice are not killed, and at the moment, the average gastric filling dosage of the mice is 1.2g/Kg of weight.
(3) Acute toxicity test: 50 mice weighing 18-21 g are taken, the male-female proportion is 1:1, the suspension is suspended at the mass concentration of 24%, each of the mice is filled with 0.1 ml, the reaction of each of the mice is carefully observed after the continuous 3 times of filling for 8 hours, the death number within 7 days is recorded, after the result of filling, the weight of each of the mice is increased, the diet is normal, no obvious toxic or side reaction is seen, and 50 mice do not die.
(4) Intraperitoneal injection: 50 mice weighing 18-21 g, wherein the male-female ratio is 1:1, were intraperitoneally injected with a 60% water decoction containing the tabletted candy product of example 1, each mouse was injected with 0.1 ml, the toxic reaction of each mouse was carefully observed, and the death number within 7 days was recorded, as a result, the mice aggregated together within 1 hour after injection, the activities were reduced, the normal state was restored later, no obvious toxic or side reaction was observed, and 50 mice did not die within 7 days. At this time, the average dose of the water decoction of the mice was 3g/Kg of body weight.
The small knot:
in the experimental mice, the dosage of the one-time gastric lavage suspension is 1.2g/Kg weight, and the suspension is given three times within 24 hours, so that the death phenomenon of the mice is not seen. The dosage for one intraperitoneal injection is 3g/Kg of body weight. The three experiments show that obvious toxic reaction and death of mice are not seen, and the toxicity of the invention is extremely low.
The vision correcting food composition of the present invention can be used for applications including, but not limited to, biscuits, tabletted candies, solid beverages, etc., and all the feeds of the food composition of the present invention such as pastries, instant foods, etc.
Claims (5)
1. A vision-correcting food composition is characterized by being prepared from the following components in parts by weight: 10-40 parts of nostoc sphaeroids kutz enzymatic hydrolysate, 10-40 parts of cock crown enzymatic hydrolysate, 10-15 parts of golden cicada enzymatic hydrolysate, 5-10 parts of sea cucumber enzymatic hydrolysate, 2-5 parts of rhizoma polygonati enzymatic hydrolysate, 10-40 parts of dunaliella salina enzymatic hydrolysate, 2-5 parts of peach kernel extract and 1-3 parts of selenium-enriched yeast powder.
2. Use of the vision-correcting food composition according to claim 1, wherein the vision-correcting food composition is prepared by mixing a flour in an amount of 10 to 30% by mass of the flour to prepare a biscuit.
3. Use of the vision-correcting food composition according to claim 2, characterized in that the vision-correcting food composition is mixed with powdered sugar in a mass ratio of 5-20:1 to prepare a tabletted candy.
4. Use of a vision-correcting food composition according to claim 2, characterized in that the vision-correcting food composition is mixed with sugar powder and fruit powder or milk powder in a mass ratio of 7-8:1-2:1 to prepare a solid beverage.
5. Use of the vision-correcting food composition according to claim 2, characterized in that the vision-correcting food composition is encapsulated in a mass ratio of 9-18:1 with starch to prepare a health-care capsule food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310459540.5A CN116918965A (en) | 2023-04-20 | 2023-04-20 | Food composition capable of correcting vision and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310459540.5A CN116918965A (en) | 2023-04-20 | 2023-04-20 | Food composition capable of correcting vision and application thereof |
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| CN202310459540.5A Pending CN116918965A (en) | 2023-04-20 | 2023-04-20 | Food composition capable of correcting vision and application thereof |
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