CN116897036A - 基于bemt和两种或更多种颜料uv过滤剂的防晒组合物 - Google Patents
基于bemt和两种或更多种颜料uv过滤剂的防晒组合物 Download PDFInfo
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- CN116897036A CN116897036A CN202280012739.7A CN202280012739A CN116897036A CN 116897036 A CN116897036 A CN 116897036A CN 202280012739 A CN202280012739 A CN 202280012739A CN 116897036 A CN116897036 A CN 116897036A
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Abstract
本发明涉及防晒组合物，该防晒组合物包含(i)双乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和(ii)至少两种颜料UV过滤剂的组合作为仅有的UV过滤剂。所述组合物表现出吸引人的皮肤感觉和外观。
Description
本发明涉及防晒组合物，该防晒组合物包含(i)双乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和(ii)两种或更多种颜料(pigmentary)UV过滤剂的组合作为仅有的UV过滤剂。所述组合物表现出吸引人的皮肤感觉和外观。
为了提供有效的对紫外辐射的防护，对防晒系数(SPF)为20或更高的防晒物的需求不断增加。然而，同时，此类防晒物仍应当表现出吸引人的肤感和外观，并且优选地甚至符合联邦食品、药品和化妆品法案的GRAS/GRASE要求。
由于其增加配方在广泛的紫外线范围内防晒系数(SPF)的能力，颜料UV过滤剂(例如无机UV过滤剂，即微粒化的(通常也称为微细的)金属氧化物，例如二氧化钛或氧化锌；或微粒化的不溶性有机UV-过滤剂)在防晒物应用中特别有用。此外，这些颜料UV过滤剂通常被认为对于化妆品使用是安全的，并且不存在大多数可溶性有机UV过滤剂那样的皮肤感觉发粘的缺点。尽管如此，与使用这种颜料UV过滤剂相关的问题仍然存在。特别是，它们的功效和实现适当(和更高)SPF水平所需的颜料粉末的相关水平使得产品在美观和感官上不可接受，例如在皮肤上提供厚重和砂砾感和/或白色/蓝色残留物。
尽管一直不乏尝试开发具有改进的感官和美学性质(例如降低的皮肤增白效果)的包含颜料UV过滤剂的有效防晒组合物，但该问题尚未得到最终满意的解决，尤其是在具有高防晒系数的制剂的情况时。
因此，持续需要开发包含颜料UV过滤剂的新型防晒制剂，其表现出改进的感官和/或美学性质，同时具有中等或更高的防晒系数(特别是SPF20或更高)。
令人惊讶的是，现在已经发现包含双乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和两种或更多种颜料UV过滤剂作为唯一的UV过滤剂物质的防晒组合物克服了现有技术的缺点。
因此，在第一实施方式中，本发明提供了这样的防晒组合物，其包含(i)双乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和(ii)两种或多种颜料UV过滤剂的UV过滤剂物质的组合作为仅有的UV过滤剂。
本发明的另一主题涉及一种在施用于皮肤之前和/或之后改善防晒组合物的感官和/或美学性质的方法，所述方法包括以下步骤：向所述组合物中掺入(i)双乙基己氧基苯酚甲氧基苯基三嗪和(ii)两种或更多种颜料UV过滤剂作为仅有的UV过滤剂物质，并任选地评价其效果。优选地，在本发明的所有实施式中，改进是降低增白效果。
因此，在另一个实施方式中，本发明涉及双乙基己氧基苯酚甲氧基苯基三嗪用于降低防晒组合物中包含的两种或更多种颜料UV过滤剂在施用于皮肤后的(皮肤)增白效果的用途。
在本发明的一类有利的实施方式中，两种或更多种颜料UV过滤剂包含至少两种无机UV过滤剂。甚至更优选地，在根据本发明的防晒组合物中包含至少一种二氧化钛UV过滤剂和至少一种氧化锌UV过滤剂。最优选地，所述防晒组合物包含(i)双乙基己氧基苯酚、(ii-a)二氧化钛UV过滤剂(或一种二氧化钛UV过滤剂)和(ii-b)氧化锌UV过滤剂(或一种氧化锌UV过滤剂)的组合作为仅有的UV过滤剂。
在另一种有利的实施方式中，两种或更多种颜料UV过滤剂包含至少一种无机UV过滤剂和至少一种微粒化的有机UV过滤剂。甚至更优选地，在根据本发明的防晒组合物中包含至少一种二氧化钛UV过滤剂和至少微粒化的亚甲基双苯并三唑基四甲基丁基苯酚。最优选地，在所述实施方式中，所述防晒组合物包含(i)双乙基己氧基苯酚甲氧基苯基三嗪、(ii-a)二氧化钛UV过滤剂(或一种二氧化钛UV过滤剂)和(ii-b)微粒化的亚甲基双苯并三唑基四甲基丁基苯酚的组合作为仅有的UV过滤剂。
应当完全理解的是，在本发明的所有实施方式中，除了UV过滤剂(i)和(ii)之外，在根据本发明的防晒组合物中不存在另外的UV过滤剂。
此外，优选的是，本发明的防晒组合物不包含有色颜料和/或特别是铁有色颜料。
有色颜料在本领域中是众所周知的并且用于赋予颜色，特别是装饰性化妆品。典型的颜料包括红色、棕色、赤褐色、黑色和黄色铁氧化物。
铁有色颜料可以是铁氧化物，例如特别是α-Fe2O3、γ-Fe2O3、Fe3O4以及FeO、红色铁氧化物、黄色铁氧化物、黑色铁氧化物和棕色铁氧化物，或者可以是包含铁氧化物层作为干涉有色颜料的一部分的有色颜料。这种铁有色颜料的实例例如在颜色索引号CI77499(铁氧化物)或CI77491(铁氧化物)下列出。包含铁氧化物层的效果颜料的实例是RonaStar RedAllure(INCI＝CI77491(铁氧化物)、CI77891(二氧化钛)、二氧化硅、云母)。
如果组合物不含(即不包含)任何水杨酸丁基辛酯(BHB)，则在本发明的所有实施方式中也是有利的。
本文使用的术语“UV过滤剂”是本领域技术人员众所周知的并且指的是基本上吸收UV-B和/或UV-A辐射的任何物质，即在300至400nm之间具有至少一个最大吸光度(峰值)。此类物质列于欧盟化妆品法规附件VI中。
所述“基本上吸收”的具体特征在于：至少130、优选地至少150或甚至至少170、例如至少200的比消光(即E1/1)。
所述比消光是本领域技术人员众所周知的，并且是指在1cm石英比色皿中相应物质的1％溶液或分散体(在颜料UV过滤剂的情况下)在λ最大处的吸光度。
本文所用的术语“颜料UV过滤剂”是指以颜料(固体)状态存在于组合物中的UV过滤剂。此类UV过滤剂是本领域技术人员众所周知的，并且涵盖无机UV过滤剂以及微粒化的不溶性有机UV过滤剂。
本发明的防晒组合物中不存在的示例性UV过滤剂是除了双乙基己氧基苯酚甲氧基苯基三嗪之外的任何其他有机可溶性UV过滤剂，例如特别是二苯甲酮-3、胡莫柳酯、水杨酸乙基己酯、甲氧基肉桂酸乙基己酯、奥克立林、乙基己基三嗪、丁基甲氧基二苯甲酰基甲烷和二乙氨基羟苯甲酰基苯甲酸己酯。
双乙基己氧基苯酚甲氧基苯基三嗪(本文也称为BEMT)也称为2,4-双{[4-(2-乙基己氧基)-2-羟基]苯基}-6-(4-甲氧基苯基)-1,3,5-三嗪(化学名)或贝莫三嗪醇(INN)(CAS号：187393-00-6)。BEMT充当广谱UV过滤剂，吸收UVB和UVA射线。其具有两个吸收峰，310nm和340nm。BEMT被建议用于防晒、日间护理、字母产品(例如BB霜)和增白产品。
在本发明的所有实施方式中，基于组合物的总重量，根据本发明的防晒组合物中BEMT的量有利地选择在0.4至10重量％的范围内，优选地在0.4至9重量％、0.4至8重量％、0.4至7重量％、0.4至6重量％、0.4至5重量％、0.4至4重量％、0.4至3重量％、0.5至3重量％、0.8至9重量％、0.8至8重量％、0.8至7重量％、0.8至6重量％、0.8至5重量％、0.8至4重量％、0.8至3重量％的范围内，例如在1至5重量％、1至3重量％、2至5重量％或2至4重量％的范围内。
本文所用的术语“无机UV过滤剂”是指具有如上所定义的UV过滤剂性能的任何金属氧化物颗粒，因此可用于掺入防晒组合物中作为UV过滤剂。这种无机UV过滤剂是本领域技术人员众所周知的并且通常被称为微粒化的或微细的二氧化钛和氧化锌。
这种无机UV过滤剂的粒径没有特别限制。一般而言，用于有效UV吸收的合适(初级)粒径选择在2至200nm的范围内。
本文所用的术语“微粒化的不溶性有机UV过滤剂”是指不溶于防晒组合物并且已经微粒化的有机UV过滤剂。它们的特点是在25℃下在水中的溶解度小于0.1重量％，并且在25℃下在常用的化妆品溶剂(例如石蜡油、环聚二甲基硅氧烷、苯甲酸C12-C15烷基酯、辛酸/癸酸甘油三酯、椰油醇辛酸酯/癸酸酯和碳酸二辛酯)中的溶解度低于1重量％。所述微粒化的不溶性有机UV过滤剂的平均粒径为0.01至2μm，更优选0.05至1.5μm，尤其是0.08至1.0μm，例如特别是80至200nm。
不溶性有机UV吸收剂可以通过常规方法转化成所期望的颗粒尺寸状态，例如通过在合适的研磨助剂存在下并使用已知的研磨设备(例如喷射磨机、球磨机、振动磨机或锤磨机，优选地高速搅拌磨机或冲击磨机，特别是旋转球磨机、振动磨机、管磨机或棒磨机)，研磨粗颗粒形式的不溶性有机UV吸收剂。
如果没有另外说明，本文给出的粒径是指通过激光衍射(例如使用Horiba粒度分布分析仪LA-960或Malvern Mastersizer 2000(ISO 13320：2009))测定的基于数量的平均粒径分布Dn50(也称为Dn0.5)。
在本发明的所有实施方式中，基于组合物的总重量，防晒组合物中颜料UV过滤剂的(总)量优选地选择在0.5至25重量％的范围内，更优选地在1至25重量％的范围内，最优选地在2至25重量％的范围内。其他合适的量选择在1至20重量％、1至15重量％、1至12重量％、3.0至20重量％、4至20重量％和5至20重量％的范围内。
在本发明的所有实施方式中，基于组合物的总重量，根据本发明的防晒组合物中无机UV过滤剂的(总)量选择在0.5至25重量％的范围内，优选地在1至20重量％的范围内，最优选地在2至15重量％的范围内。基于组合物的总重量，其他合适的量选择在1至15重量％、2至15重量％、3至15重量％、1至10重量％、2至10重量％和3至10重量％的范围内。
在本发明的所有实施方式中，基于组合物的总重量，根据本发明的防晒组合物中微粒化的不溶性有机UV过滤剂的(总)量选择在0.5至10重量％的范围内，优选地在1至10重量％的范围内，更优选地在2至10重量％的范围内，最优选地在2至6重量％或3至6重量％的范围内。
甚至更有利地，基于组合物的总重量，根据本发明的防晒组合物中无机二氧化钛UV过滤剂的(总)量选择在0.5至15重量％的范围内，优选地在1至15重量％的范围内，更优选地在2至10重量％的范围内，最优选地在2至6重量％或3至6重量％的范围内。
甚至更有利地，基于组合物的总重量，根据本发明的防晒组合物中无机氧化锌UV过滤剂的(总)量选择在0.5至24.5重量％的范围内，优选地在1至15重量％的范围内，更优选地在2至15重量％的范围内，最优选地在5至15重量％或7.5至15重量％的范围内。
优选地，在本发明的所有实施方式中，二氧化钛UV过滤剂与氧化锌UV过滤剂的比率(w/w)选择在1:5至5:1的范围内，优选地1:2至2:1。甚至更优选地，根据本发明的防晒组合物中氧化锌的量高于二氧化钛的量，例如在5:1至1.25:1的范围内，最优选地在2.5:1至1.25:1的范围内。
根据本发明，有利的是无机UV过滤剂是经表面涂覆的。表面涂层可以包括通过本身已知的方法为金属氧化物颗粒提供薄的亲水性或疏水性无机或有机层。根据本发明，不同的表面涂层还可以包含水。由于表面处理，金属氧化物被赋予亲水性、两亲性或疏水性特征。
适用于本发明目的的无机表面涂层的实例包括氧化铝(Al2O3)、氢氧化铝Al(OH)3、水合氧化铝(又名：氧化铝，CAS号：1333-84-2)、六偏磷酸钠(NaPO3)6、偏磷酸钠(NaPO3)n、二氧化硅(SiO2)(又名：硅石，CAS号：7631-86-9)和氧化铁(Fe2O3)。这些无机表面涂层可以单独存在、组合存在和/或与有机涂层材料组合存在，特别是如下所述。
适用于本发明的有机表面涂层的实例包括植物或动物硬脂酸铝、脂肪酸(如硬脂酸和月桂酸)、二甲基聚硅氧烷(又名：聚二甲基硅氧烷)、甲基聚硅氧烷(聚甲基硅氧烷)、西甲硅油(simethicone)、三乙氧基辛基硅烷、辛基三甲氧基硅烷和鲸蜡醇磷酸酯(例如鲸蜡醇磷酸酯钾)及其任何混合物。这些有机表面涂层可以单独存在、组合存在和/或与无机涂层材料组合存在。
二氧化钛的晶体形式可以是任何晶体或无定形类型。例如，二氧化钛可以是任何类型的无定形、金红石、锐钛矿、板钛矿或其混合物。优选地，在本发明的所有实施方式中，二氧化钛的晶体形式是金红石。
此外优选的是，氧化锌是由以纤锌矿晶体结构存在的氧化锌组成的白色粉末。
根据本发明使用的二氧化钛UV过滤剂(包括其任何预分散体)是例如可在帝斯曼营养产品有限公司作为TX(INCI：二氧化钛、二氧化硅、聚二甲基硅氧烷)、或可在Tayca作为微二氧化钛MT-01或可在石原产业株式会社作为TTO-55I获得的。同样合适的是具有内部氧化铝涂层和外部西甲硅油涂层的双层涂覆的二氧化钛，例如可在EMDchemicals Inc./Rona作为Eusolex T-2000商购获得。
用于根据本发明使用的氧化锌UV过滤剂(包括其任何预分散体)是例如可从自BASF作为Z-Cote或Z-Cote HP1(2％聚二甲基硅氧烷涂层)获得的，可从自Tayca作为MZ-505S(5％聚二甲基硅氧烷涂层)获得的，或可从帝斯曼营养产品有限公司作为ZX(2-3.5％的三乙氧基辛基硅烷涂层)。
在一个具体实施方式中，根据本发明的防晒组合物包含作为无机UV过滤剂的至少一种双面涂覆的二氧化钛和至少一种涂覆的氧化锌，最优选地不存在任何其他微细金属氧化物(即一种双面涂覆的二氧化钛和一种涂覆的氧化锌)。
最优选地，在根据本发明的所有实施方式中，二氧化钛UV过滤剂是双层涂覆的二氧化钛，甚至更优选地是具有内部二氧化硅和外部有机涂层的双层涂覆的二氧化钛，或者是二氧化硅涂覆的二氧化钛。
优选地，双面涂覆的二氧化钛的内部二氧化硅涂层由最少0.5重量％的无机二氧化硅(基于二氧化钛)组成。更优选地，内涂层由0.5重量％至50重量％、最优选地1重量％至20重量％的无机二氧化硅(基于二氧化钛)组成。
双层涂覆的二氧化钛的外涂层优选地选自有机涂层一类的物质，例如硅油(例如西甲硅油、聚甲基硅氧烷、聚二甲基硅氧烷、聚硅氧烷-15)、烷基硅烷(例如辛基三甲氧基硅烷或辛基三乙氧基硅烷)、烯酸(例如硬脂酸)或多元醇(例如甘油)，并且可以通过本领域技术人员已知的方法(例如FI57124中描述的方法)施用于二氧化钛颗粒。优选地，外涂层选自西甲硅油、聚甲基硅氧烷、聚二甲基硅氧烷、聚硅氧烷-15、硬脂酸和辛基三甲氧基硅烷。最优选地，外涂层是聚二甲基硅氧烷。甚至更优选地，外涂层的量为基于二氧化钛的至少0.25重量％。优选地，基于二氧化钛，外涂层的量选择在0.5重量％至50重量％的范围内，最优选地在0.5重量％至10重量％的范围内。
在本发明的所有实施方式中，根据本发明的双面涂覆的二氧化钛优选地具有选择在70-95重量％范围内的二氧化钛含量和选择在5-20重量％范围内的二氧化硅含量，例如优选地选择在80-90重量％范围内的二氧化钛含量并且选择在10至15重量％范围内的二氧化硅含量，前提条件是二氧化钛和二氧化硅的总含量选择在90-100重量％范围内。
优选地，双面涂覆的二氧化钛具有2至100nm、更优选地5至50nm、最优选10至25nm的平均初级粒径和0.025nm至1μm、例如优选地在0.05μm至0.075μm的次级粒径。
根据本发明的特别合适的双层涂覆的二氧化钛包含具有二氧化硅(内涂层)和聚二甲基硅氧烷(外涂层)的双层涂层的金红石型二氧化钛(TiO2)核，并且二氧化钛含量为至少75重量％，优选地在82-87重量％的范围内，并且二氧化硅含量为至少10重量％，优选地在10.5至14.5重量％的范围内，并且平均粒径分布Dn50为25至100nm，优选地40至80nm(使用Malvern Mastersizer 2000通过激光衍射测量进行分析)，该双层涂覆的二氧化钛例如可以在帝斯曼营养产品有限公司作为TX(INCI：二氧化钛、二氧化硅、聚二甲基硅氧烷)商购获得。
最优选地，在根据本发明的所有实施方式中，氧化锌是未涂覆的，或者涂覆有三乙氧基辛基硅烷。最优选地，氧化锌是由以纤锌矿晶体结构存在的氧化锌组成、涂覆有三乙氧基辛基硅烷的白色粉末，其氧化锌含量为96-98％，三乙氧基辛基硅烷含量为2-3.5％，平均粒径为90至130nm(使用Malvern Mastersizer 2000通过激光衍射测量进行分析)，其可从帝斯曼营养产品有限公司作为ZX商购获得。
优选的微粒化的不溶性有机UV过滤剂包括微粒化亚甲基双苯并三唑基四甲基丁基苯酚和微粒化三联苯三嗪。在本发明的所有实施方式中最优选的是使用微粒化的亚甲基双苯并三唑基四甲基丁基苯酚。所述UV过滤剂可从帝斯曼营养产品有限公司在MAX商品名下或从巴斯夫在/>A2B下作为其水性分散体获得。除了含量为40至60重量％的相应的微粒化的UV过滤剂之外，所述分散体基本上由5至10重量％的癸基葡糖苷、0.1至1重量％的增稠剂(例如黄原胶)和0至1.5重量％的添加剂(例如特别选自丙二醇、丁二醇、磷酸二钠和/或硅消泡剂(例如西甲硅油))组成。所述微粒化的不溶性有机UV过滤剂表现出通过FOQELS技术测量的在约100至约150nm(基于质量)的范围内的平均粒径d(0.5)，例如消费者安全科学委员会(Scientific Committee on Consumer Safety，SCCS)关于2,2'-亚甲基-双-(6-(2H-苯并三唑-2-基)-4-(1,1,3,3-四甲基丁基)苯酚)和2,4,6-三[1,1'-联苯]-4-基)-1,3,5-三嗪的意见中所概述的平均粒径d(0.5)。
特别合适的亚甲基双苯并三唑基四甲基丁基苯酚(MBBT)的分散体本质上由45至55重量％的MBBT、6.0至10.0重量％的癸基葡糖苷、0.2至0.6重量％的丙二醇、0.1至0.5重量％的黄原胶和水(加至100重量％)组成。
特别合适的三联苯三嗪(TBPT)分散体本质上由47至53重量％的TBPT、6.5至8.5重量％的癸基葡糖苷、0.2至0.6重量％的磷酸二钠、0.2至0.6重量％的丁二醇、0.1至0.3重量％的黄原胶和水(加至100重量％)组成。
根据本发明的颜料UV滤光剂(ii)的特别有利的组合包括具有内部二氧化硅和外部聚二甲基硅氧烷涂层的双层涂覆的二氧化钛和涂覆有三乙氧基辛基硅烷的氧化锌的组合，二氧化硅涂覆的二氧化钛和未涂覆的氧化锌的组合，以及具有内部二氧化硅和外部聚二甲基硅氧烷涂层的双层涂覆的二氧化钛与微粒化的不溶性有机UV过滤剂亚甲基双苯并三唑基四甲基丁基苯酚的组合。
由于本发明的防晒组合物旨在用于局部施用，因此应充分理解的是，它们包含生理学上可接受的介质，即与角质物质(例如皮肤、粘膜和角质纤维)相容的介质。特别地，生理学上可接受的介质是美容学上可接受的载体。
本文所用的术语“美容学上可接受的载体”是指常规用于局部化妆品组合物(例如特别是皮肤护理制剂中)的所有载体和/或赋形剂和/或稀释剂。
载体的精确量将取决于UV过滤剂和本领域普通技术人员将会分类为与载体不同的任何其他任选成分(例如，其他活性成分)的实际水平。
在一个有利的实施方式中，基于防晒组合物的总重量，本发明的防晒组合物包含50％至99％、优选地60％至98％、更优选地70％至98％、例如特别是80％至95％的载体。
在一个特别有利的实施方式中，载体还由至少30重量％、更优选地至少40重量％、最优选地至少45重量％的水、例如特别是50至90重量％的水组成。
具体地，根据本发明的防晒组合物是化妆品或药物组合物，优选地化妆品(非治疗性)组合物。
在一种实施方式中，将本发明的防晒组合物施用于哺乳动物角质组织，例如特别是人皮肤或人头皮和头发。
本申请中使用的术语“化妆品组合物”是指在1997年的Lexikon Chemie，Georg Thieme Verlag Stuttgart，纽约第10版中标题“Kosmetika”下所定义的化妆品组合物，以及在1992年的A.Domsch，“Cosmetic Compositions”，Verlag für chemischeIndustrie(ed.H.Ziolkowsky)第4版中公开的化妆品组合物。
本发明的优选的防晒组合物是皮肤护理制剂、装饰性制剂和功能性制剂。
皮肤护理制剂的实例特别是光防护制剂、抗衰老制剂、治疗光老化的制剂、身体油、身体乳液、身体凝胶、护理霜、皮肤防护软膏、皮肤粉末、保湿凝胶、保湿喷雾剂、面部和/或身体保湿剂、皮肤美黑制剂(即用于人类皮肤的人工/免晒晒黑和/或变褐色的组合物)，例如仿晒霜以及亮肤制剂。
装饰性制剂的实例具体为口红、眼影、睫毛膏、干和湿化妆制剂、胭脂和/或粉。
功能性制剂的实例是含有活性成分的化妆品或药物组合物，例如但不限于激素制剂、维生素制剂、植物提取物制剂、抗衰老制剂和/或抗微生物(抗细菌或抗真菌)制剂。
在一个具体实施方式中，根据本发明的防晒组合物是光防护制剂(防晒产品、防晒霜)，例如防晒乳、防晒乳液、防晒霜、防晒油、防晒隔离霜或具有SPF(防晒系数)的热带护理霜或日间护理霜。特别令人感兴趣的是防晒霜、防晒乳液和防晒乳。
本发明的组合物(包括载体)可以包含常规的佐剂和添加剂，例如防腐剂/抗氧化剂、脂肪物质/油、有机溶剂、硅氧烷、增稠剂、软化剂、乳化剂、消泡剂、美容成分(例如香料，表面活性剂，填充剂，阴离子、阳离子、非离子或两性聚合物或其混合物)、推进剂、酸化剂或碱化剂、染料、色素/着色剂、研磨剂、吸收剂、螯合剂和/或多价螯合剂、精油、皮肤感觉剂、收敛剂、颜料或任何通常配制成此类组合物的其他成分。
按照本发明，根据本发明的组合物可以包含另外的成分，例如用于皮肤增亮的成分；预防晒黑的成分；治疗色素沉着过度的成分；预防或减少痤疮、皱纹、细纹、萎缩和/或炎症的成分；螯合剂和/或多价螯合剂；抗橘皮组织和纤体剂(例如，植烷酸)、紧致剂、保湿剂和活肤(energizing)剂、自助美黑剂、舒缓剂、以及改善弹性和皮肤屏障的试剂，以及防晒组合物中常规使用的载体和/或赋形剂或稀释剂。
如果没有另外说明，下面提到的赋形剂、添加剂、稀释剂等适合用于根据本发明的防晒组合物。本领域技术人员可以根据所期望的产品容易地确定化妆品和皮肤病助剂和添加剂的必要量。
另外的成分可以添加到油相、水相中或单独添加，视情况而定。本领域技术人员可以容易地调整添加模式。
适合用于本发明的化妆品组合物的化妆品赋形剂、稀释剂、佐剂、添加剂以及皮肤护理工业中常用的活性成分的实例例如描述于个人护理产品委员会(Personal CareProduct Council)(http://www.personalcarecouncil.org/)的International CosmeticIngredient Dictionary&Handbook中，可通过在线的INFO BASE(http://online.personalcarecouncil.org/jsp/Home.jsp)访问，但不限于此。
可用于本文的美容活性成分在一些情况下可以提供多于一种的益处或通过多于一种的作用模式运作。
当然，本领域技术人员将注意选择上述任选的另外的成分、佐剂、稀释剂和添加剂和/或它们的量，使得与根据本发明的组合本质上相关的有利性质不受到、或者基本上不受到所设想的添加的不利影响。
在本发明的所有实施方式中，优选的防晒组合物是含有油相和水相的乳液，例如特别是O/W、W/O、Si/W、W/Si、O/W/O、W/O/W多重乳液或一次皮克林乳液。基于组合物的总重量，此类乳液中存在的油相(即包含所有油和脂肪的相)的量优选地为至少10重量％，例如在10至60重量％的范围内，优选地在15至50重量％的范围内，最优选地在15至40重量％的范围内。
根据一个甚至更优选的实施方式，本文中概述的根据本发明的防晒组合物是O/W乳液，其包含在O/W乳化剂存在下分散在水相中的油相。这种O/W乳液的制备是本领域技术人员众所周知的并且在实施例中进行了说明。
在一个有利的实施方式中，O/W乳化剂是磷酸酯乳化剂。其中优选的磷酸酯乳化剂为C8-10烷基乙基磷酸酯、C9-15烷基磷酸酯、鲸蜡硬脂醇聚醚-2磷酸酯、鲸蜡硬脂醇聚醚-5磷酸酯、鲸蜡醇聚醚-8磷酸酯、鲸蜡醇聚醚-10磷酸酯、十六烷基磷酸酯、C6-10链烷醇聚醚-4磷酸酯、C12-15链烷醇聚醚-2磷酸酯、C12-15链烷醇聚醚-3磷酸酯、DEA-鲸蜡硬脂醇聚醚-2磷酸酯、DEA-十六烷基磷酸酯、DEA-油醇聚醚-3磷酸酯、鲸蜡醇磷酸酯钾、癸醇聚醚-4磷酸酯、癸醇聚醚-6磷酸酯和三月桂醇聚醚-4磷酸酯。根据本发明的具体磷酸酯乳化剂是鲸蜡醇磷酸酯钾，例如可在DSM Nutritional Products Ltd Kaiseraugst作为K商购获得。
根据本发明的其他合适的O/W乳化剂包括：PEG-30二聚羟基硬脂酸酯、PEG-4二月桂酸酯、PEG-8二油酸酯、PEG-40失水山梨醇全油酸酯、PEG-7甘油椰油酸酯、PEG-20杏仁甘油酯类、PEG-25氢化蓖麻油、甘油硬脂酸酯(和)PEG-100硬脂酸酯、PEG-7橄榄油酸酯、PEG-8油酸酯、PEG-8月桂酸酯、PEG-60杏仁甘油酯类、PEG-20甲基葡萄糖倍半硬脂酸酯、PEG-40硬脂酸酯、PEG-100硬脂酸酯、PEG-80失水山梨醇月桂酸酯、硬脂醇聚醚-2、硬脂醇聚醚-12、油醇聚醚-2、鲸蜡醇聚醚-2、月桂醇聚醚-4、油醇聚醚-10、油醇聚醚-10/聚氧乙烯10油醚、鲸蜡醇聚醚-10、异硬脂醇聚醚-20、鲸蜡硬脂醇聚醚-20、油醇聚醚-20、硬脂醇聚醚-20、硬脂醇聚醚-21、鲸蜡醇聚醚-20、异鲸蜡醇聚醚-20、月桂醇聚醚-23、硬脂醇聚醚-100、甘油硬脂酸酯柠檬酯、硬脂酸甘油酯(自乳化)、硬脂酸、硬脂酸盐、聚甘油-3-甲基葡糖二硬脂酸酯。其他合适的乳化剂是脱水山梨醇油酸酯、脱水山梨醇倍半油酸酯、脱水山梨醇异硬脂酸酯、脱水山梨醇三油酸酯、月桂基葡糖苷、癸基葡糖苷、硬脂酰谷氨酸钠、蔗糖聚硬脂酸酯和水合聚异丁烯。此外，一种或多种合成聚合物可以用作乳化剂。例如，PVP二十碳烯共聚物、丙烯酸酯/丙烯酸C10-30烷基酯交联聚合物、丙烯酸酯/硬脂醇聚醚-20甲基丙烯酸酯共聚物、PEG-22/十二烷基二醇共聚物、PEG-45/十二烷基二醇共聚物及其混合物。
另一类特别合适的O/W乳化剂是源自橄榄油的非离子自乳化体系，例如称为(INCI名称)鲸蜡硬脂醇橄榄油酸酯和山梨坦橄榄油酸酯(化学成分：橄榄油脂肪酸的鲸蜡硬脂醇酯和山梨糖醇酐酯)，其在商品名OLIVEM 1000下出售。
进一步合适的是可商购的聚合乳化剂，例如疏水改性的聚丙烯酸，例如丙烯酸酯/丙烯酸C10-30烷基酯交联聚合物，其可由Noveon在商品名TR-1和TR-2下商购获得。
另一类特别合适的乳化剂是脂肪酸的二酯或聚甘油酯，也称为聚甘油酯/二酯(即其中脂肪酸通过与聚甘油酯化而结合的聚合物)，例如在Evonik作为Isolan GPS[INCI名称聚甘油-4二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯(即异硬脂酸、聚羟基硬脂酸和癸二酸的混合物与聚甘油-4的二酯)]可商购的或在Cognis作为Dehymuls PGPH(INCI聚甘油-2二聚羟基硬脂酸酯)可商购的。
还合适的是聚亚烷基二醇醚，例如Brij 72(聚氧乙烯(2)硬脂醇醚)或Brij721(聚氧乙烯(21)硬脂醇醚，例如可从Croda获得)。
根据本发明的特别有利的O/W乳化剂是以下中的一种或多种：聚甘油-3-甲基葡萄糖二硬脂酸酯、月桂基葡糖苷(和)聚甘油-2-二聚羟基硬脂酸酯、甘油硬脂酸酯柠檬酸酯、鲸蜡硬脂醇硫酸酯钠、鲸蜡硬脂基葡糖苷；聚甘油-6硬脂酸酯(和)聚甘油-6山嵛酸酯、鲸蜡硬脂基橄榄油酸酯(和)山梨坦橄榄油酸酯酯、花生醇(和)山嵛醇(和)花生糖苷、鲸蜡硬脂醇(和)椰油基葡糖苷、椰油基葡糖苷(和)椰子醇、PEG-100硬脂酸酯(和)硬脂酸甘油酯、硬脂酰谷氨酸钠、硬脂醇聚醚-20、硬脂醇聚醚-21、硬脂醇聚醚-25、硬脂醇聚醚-2、鲸蜡硬脂醇聚醚-25和鲸蜡硬脂醇聚醚-6(全部按INCI名称列出)。
根据本发明，特别优选的是，组合物包含鲸蜡醇磷酸酯钾作为乳化剂。
基于组合物的总重量，所述至少一种O/W或Si/W乳化剂优选地以0.5至10重量％的量使用，例如特别是在0.5至5重量％的范围内，例如最特别是在0.5至4重量％的范围内。
根据本发明合适的W/O-或W/Si-乳化剂是聚甘油基-2-二聚羟基硬脂酸酯、PEG-30二聚羟基硬脂酸酯、鲸蜡基聚二甲基硅氧烷共聚醇、油酸/异硬脂酸的聚甘油基-3二异硬脂酸酯、聚甘油基-6六蓖麻酸酯、聚甘油基-4-油酸酯、十六烷醇-4油酸酯/PEG-8丙二醇椰油酸酯、硬脂酸镁、硬脂酸钠、月桂酸钾、蓖麻油酸钾、椰油酸钠、牛油酸钠、蓖麻酸钾、油酸钠、以及它们的混合物。其他合适的W/Si-乳化剂是月桂基聚甘油基-3聚二甲基硅氧基乙基聚二甲基硅氧烷和/或PEG-9聚二甲基硅氧基乙基聚二甲基硅氧烷和/或鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷和/或PEG-12聚二甲基硅氧烷交联聚合物和/或PEG/PPG-18/18聚二甲基硅氧烷。相对于组合物的总重量，所述至少一种W/O乳化剂的用量优选为约0.001至10重量％，更优选为0.2至7重量％。
本发明的防晒组合物还有利地含有至少一种辅助表面活性剂，例如选自甘油单酯和甘油二酯和/或脂肪醇。基于组合物的总重量，辅助表面活性剂的用量通常选择在0.1至10重量％的范围内，例如特别是在0.5至7重量％的范围内，例如最特别是在1至5重量％的范围内。特别合适的辅助表面活性剂选自以下列表：烷基醇，例如鲸蜡醇(Lorol C16，Lanette 16)、鲸蜡硬脂醇(Lanette O)、硬脂醇(Lanette 18)、山萮醇(Lanette 22)、聚羟基硬脂酸、甘油硬脂酸酯、甘油肉豆蔻酸酯(Estol 3650)、氢化椰油甘油酯(LipocireNa10)及其混合物。
在本发明的所有实施方式中，如果组合物还包含鲸蜡醇、硬脂醇和/或硬脂酸甘油酯，优选硬脂醇，则是特别有利的。
如果本发明的局部组合物还包含聚羟基硬脂酸及其混合物，则是特别有利的。
请检查以下部分，尤其是考虑到添加应涵盖并可用于产生(i)市场相关新颖性和/或创造性的其他成分时。
本发明组合物的有利实施方式还包括下面这些实施方式：其中组合物包含一种或多种选自丁二醇二辛酸酯/二癸酸酯、苯甲酸苯乙酯、苯甲酸C12-C15烷基酯、己二酸二丁酯、癸二酸二异丙酯、碳酸二辛酯、酒石酸二C12-13烷基酯、丁香亚基丙二酸二乙基己酯、氢化蓖麻油二聚体、三庚酸甘油酯、乳酸C12-13烷基酯、苯甲酸C16-17烷基酯、辛酸丙基庚酯、辛酸/癸酸甘油三酯、2,6-萘二甲酸二乙基己酯、辛基十二烷醇、椰油酸乙基己酯中的一个或多个。优选地，根据本发明的组合物包含作为油的丁二醇、己二酸二丁酯、苯甲酸苯乙酯、碳酸二辛酯、苯甲酸C12-C15烷基酯、碳酸辛酯、癸酸/辛酸甘油三酯及其混合物，最优选地丁二醇、苯甲酸苯乙酯和苯甲酸C12-C15烷基酯。
在本发明的另一个有利的方面，本发明的防晒组合物还包含防腐剂和/或防腐促进剂，优选地选自乙醇、苯氧基乙醇、乙基己基甘油、己基甘油、辛酸甘油酯、1,2-戊二醇、1,2-己二醇、1,2-辛二醇(辛甘醇)、1,2-癸二醇和2-甲基-1,3-丙二醇及其混合物，最优选地选自苯氧基乙醇和乙基己基甘油及其混合物。当存在时，基于组合物的总重量，防腐剂或防腐促进剂优选地以0.01至2重量％的量使用，更优选地0.05至1.5重量％，最优选地0.1至1.0重量％。
根据本发明有利的是，该制剂包含一种或多种选自1,2-戊二醇、1,2-己二醇、1,2-辛二醇、1,2-癸二醇和2-甲基-1,3-丙二醇的链烷二醇。基于组合物的总重量，当存在时，一种或多种链烷二醇优选地以0.1至7重量％的量、更优选地0.5至7重量％、最优选地1.0至5.0重量％的量使用。
根据本发明，如果本发明的组合物包含乙醇、苯氧基乙醇和/或乙基己基甘油，则是进一步有利的。
在另一个有利的方面，根据本发明的防晒组合物不含任何对羟基苯甲酸酯(parabene)、苄索氯铵(benzethoniumchlorid)、吡罗克酮乙醇胺(piroctone olamine)、月桂酰精氨酸、甲基异噻唑啉酮、氯甲基异噻唑啉酮、布罗波尔(bronopol)、苯扎氯铵、释放甲醛的化合物、水杨酸、三氯生、DMDM乙内酰脲、氯苯甘醚和IPBC(碘代丙炔基丁基氨基甲酸酯)。
本发明的防晒组合物还可包含一种或多种舒缓和软化皮肤的润肤剂。作为示例，润肤剂可以是硅酮(聚二甲基硅氧烷、环聚二甲基硅氧烷)、植物油(葡萄籽、芝麻籽、荷荷巴油等)、黄油(可可脂、乳木果油)和矿脂衍生物(矿脂膏、矿物油)。
另一方面，本发明的防晒组合物可以包含一种或多种香料，香料选自柠檬烯、柠檬醛、芳樟醇、α-异甲基紫罗兰酮、香叶醇、香茅醇、2-异丁基-4-羟基-4-甲基四氢吡喃、乙酸2-叔戊基环己酯、3-甲基-5-苯基-1-戊醇、7-乙酰基-1,1,3,4,4,6-六甲基四氢化萘、己二酸二酯、肉桂醛、水杨酸戊酯、α-戊基肉桂醛、α-甲基紫罗兰酮、丁基苯基甲基丙醛、肉桂醛、戊基肉桂醇、茴香醇、安息香、苯甲醇、苯甲酸苄酯、肉桂酸苄酯、水杨酸苄酯、佛手柑油、苦橙油、丁基苯基甲基丙醛、小豆蔻油、雪松醇、肉桂醛、肉桂醇、甲基巴豆酸香茅酯、柑橘油、香豆素、琥珀酸二乙酯、乙基芳樟醇、丁子香酚、Evernia Furfuracea提取物、Everniaprunastri提取物、金合欢醇、愈创木油、己基肉桂醛、水杨酸己酯、羟基香茅醛、薰衣草油、柠檬油、乙酸芳樟酯、柑橘油、薄荷基PCA、甲基十六烷、肉豆蔻油、迷迭香油、甜橙油、松油醇、零陵香豆油(tonkabean oil)、柠檬酸三乙酯、香草醛。
本发明的组合物可以有利地包含保湿剂。保湿剂是这样的化合物或化合物的混合物：其赋予化妆品组合物在施用到或分布在皮肤表面上之后减少角质层水分损失(也称为经表皮失水(TEWL))的品质地和/或积极影响角质层的水合作用的品质。
用于本发明的有利的保湿剂的非限制性实例包括甘油、乳酸和/或乳酸盐(尤其是乳酸钠)、丁二醇、丙二醇、生物糖胶-1、野生大豆(Glycine soya)、乙基己氧基甘油、吡咯烷酮甲酸和尿素。特别地，进一步的优点是使用聚合物保湿剂，聚合物保湿剂选自水溶性和/或在水中可溶胀和/或借助水可胶凝的多糖。特别有利的例如是透明质酸、壳聚糖和/或富含岩藻糖的多糖(其在化学文摘(Chemical Abstracts)中注册，注册号为178463-23-5并且是可以获得的，例如可以从SOLABIA S.A公司在1000名称下获得。保湿剂还可以有利地用作活性抗皱成分，以防止例如皮肤老化中发生的皮肤变化。
本发明的化妆品组合物还可以有利地但不是强制性地包含填充剂，填充剂具有以下效果：例如进一步改善制剂的感觉和化妆性质以及引起或增强例如天鹅绒般或丝滑的皮肤感觉。在本发明意义上有利的填充剂是淀粉和淀粉衍生物(例如木薯淀粉、磷酸二淀粉、淀粉辛烯基琥珀酸钠或淀粉辛烯基琥珀酸铝等)、既不具有主要UV过滤效果也不具有着色效果的Vavance颜料(例如Valvance Touch 210或250)和/或(CAS号7631-86-9)和/或滑石和/或聚乙烯、尼龙和二氧化硅二甲基甲硅烷基化物。
本发明组合物的水相可以有利地包含常规化妆品助剂，例如醇，特别是低碳数的醇，优选地乙醇和/或异丙醇，或低碳数的多元醇，以及它们的醚，优选地丙二醇、甘油；电解质；自晒黑剂；以及特别是一种或多种增稠剂，其可以有利地选自二氧化硅、硅酸铝、多糖和/或其衍生物，例如透明质酸、黄原胶、羟丙基甲基纤维素，特别有利地选自聚丙烯酸酯，优选地选自卡波姆(Carbopol)的组的聚丙烯酸酯，实例为980、981、1382、2984和5984型卡波姆，在每种情况下单独或组合。根据本发明有利的其他增稠剂是具有INCI名称丙烯酸酯/丙烯酸C10-30烷基酯交联聚合物(Acrylates/C10-30 Alkyl Acrylate Crosspolymer)(例如，来自NOVEON的Pemulen TR 1、Pemulen TR 2、Carbopol 1328)以及Aristoflex AVC(INCI：丙烯酰二甲基牛磺酸铵/VP共聚物(Ammonium Acryloyldimethyltaurate/VPCopolymer))以及Simugel NS(INCI：丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物&角鲨烷&聚山梨醇酯60(Hydroxyethyl Acrylate/Sodium Acryloyldimethyl TaurateCopolymer&Squalane&Polysorbate 60))的那些。
根据本发明，优选地，组合物包含黄原胶、交联的丙烯酸酯/丙烯酸C10-C30烷基酯聚合物、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物和/或乙烯基吡咯烷酮/十六烷共聚物，优选地黄原胶和/或丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠。
本发明的防晒组合物使用总量惊人地少的UV过滤剂。
在另一个方面，组合物可具有至少20、优选地至少30的SPF。
有利地，根据本发明，本发明的组合物包含成膜剂。本发明意义上的成膜剂是具有各种组成的物质并且其特征在于以下性质：当成膜剂溶解在水或其他合适的溶剂中，然后将该溶液涂敷到皮肤上时，成膜剂在溶剂蒸发后形成薄膜，该薄膜本质上用于将UV过滤剂固定在皮肤上，并且从而提高产品的防水性能。
特别有利的是从基于聚乙烯吡咯烷酮(PVP)的聚合物组中选择成膜剂。
特别优选的是乙烯基吡咯烷酮的共聚物，例如PVP十六烷共聚物和PVP二十碳烯共聚物，其可以在商品名Antaron V216和Antaron V220下从GAF Chemicals Corporation获得。
同样有利的是其他聚合物成膜剂，例如聚苯乙烯磺酸钠，其可以在商品名Flexan130下从National Starch and Chemical Corp.获得，和/或聚异丁烯，其可以在商品名Rewopal PIB1000下从Rewo获得。其他合适的聚合物的实例是聚丙烯酰胺(Seppigel 305)、聚乙烯醇、PVP、PVP/VA共聚物、聚乙二醇、丙烯酸酯/辛基丙烯酰胺共聚物(Dermacryl 79)。同样有利的是使用氢化蓖麻油二聚体二亚油酸酯(CAS 646054-62-8，INCI氢化蓖麻油二聚体二亚油酸酯)，其可以在名称Risocast DA-H下从Kokyu Alcohol Kogyo获得，或者PPG-3苄基醚肉豆蔻酸酯(CAS 403517-45-3)，其可以在商品名Crodamol STS下从CrodaChemicals获得。
本发明的防晒组合物通常具有3至10范围内的pH，优选地4至8范围内的pH，最优选地4至7范围内的pH。可以根据本领域的标准方法，根据需要用合适的酸(例如柠檬酸)或碱(例如NaOH)容易地调节pH。
根据本发明，本发明的组合物用于防止皮肤老化(尤其是用于防止UV引起的皮肤老化)的用途以及作为防晒组合物的用途。
最后，本发明的主题是用于对角蛋白物质(例如特别是皮肤)的美容处理的方法，其中将本文限定的组合物施用于所述角蛋白物质(例如特别是皮肤)。该方法特别适合保护皮肤免受UV辐射的不利影响，例如特别是晒伤和/或光老化，同时降低颜料UV过滤剂(例如特别是选自二氧化钛和/或氧化锌和/或微粒化的亚甲基双苯并三唑基四甲基丁基苯酚的无机UV过滤剂)的皮肤增白效果。
下面通过实施例进一步说明本发明的组成和效果。这些实施例仅是说明性的并且不旨在以任何方式限制本发明的范围。
实验部分
已根据本领域的标准方法制备了表1中列出的制剂(O/W乳液)。然后按照以下方法对LENETA黑卡进行增白测试：
-在LENETA黑卡上涂抹300mg霜(cream)(每种配方使用3张卡)
-通过涂抹装置(速度：10mm/s)使用60mm涂抹刀来涂抹霜，以获得均匀的膜厚度
-让霜膜在室温下干燥1小时
-由Minolta Chroma Meter CR-300测量LAB，每张卡上3个测量点
-计算平均L值并进行比较。
结果概要地示于表1中。
表1：防晒配方(O/W乳液)
*DSM防晒优化剂
从表1可以看出，BEMPT的添加导致L值降低，反映了组合物的增白效果降低，该效果在无机颜料与有机颜料组合时尤其明显。
Claims (15)
1.一种防晒组合物，其包含(i)双乙基己氧基苯酚甲氧基苯基三嗪(BEMT)和(ii)两种或更多种颜料UV过滤剂的组合作为仅有的UV过滤剂。
2.根据权利要求1所述的防晒组合物，其中基于所述组合物的总重量，双乙基己氧基苯酚甲氧基苯基三嗪的量选自0.4至10重量％的范围，优选地0.8至5重量％的范围，最优选地1至5重量％的范围。
3.根据权利要求1或2所述的防晒组合物，其中基于所述组合物的总重量，所述两种或更多种颜料UV过滤剂的量选自0.5至25重量％的范围，优选地1至20重量％的范围，最优选地2至15重量％的范围。
4.根据权利要求1至3中任一项所述的防晒组合物，其中所述两种或更多种颜料UV过滤剂包含至少两种无机UV过滤剂，优选地至少一种二氧化钛UV过滤剂和至少一种氧化锌UV过滤剂。
5.根据权利要求1至3中任一项所述的防晒组合物，其中所述两种或更多种颜料UV过滤剂包含至少一种无机UV过滤剂和至少一种微粒化的不溶性有机UV过滤剂，优选地微粒化的亚甲基双苯并三唑基四甲基丁基苯酚。
6.根据权利要求4或5所述的防晒组合物，其中所述无机UV过滤剂是经过表面涂覆的。
7.根据前述权利要求中任一项所述的防晒组合物，其中所述无机UV过滤剂选自具有内部二氧化硅涂层和外部聚二甲基硅氧烷涂层的双层涂覆的二氧化钛、二氧化硅涂覆的二氧化钛、未涂覆的氧化锌和涂有三乙氧基辛基硅烷的氧化锌。
8.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物是O/W乳液，其包含在O/W乳化剂存在下、优选地在鲸蜡醇磷酸酯乳化剂存在下、最优选地在鲸蜡醇磷酸酯钾乳化剂的存在下分散在水相中的油相。
9.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物进一步包含丁二醇、二辛酸酯/二癸酸酯、苯甲酸苯乙酯、苯甲酸C12-C15烷基酯、己二酸二丁酯、癸二酸二异丙酯、碳酸二辛酯、酒石酸二C12-13烷基酯、氢化蓖麻油二聚体、三庚酸甘油酯、乳酸C12-13烷基酯、苯甲酸C16-17烷基酯、辛酸丙基庚基酯、辛酸/癸酸甘油三酯、2,6-萘二甲酸二乙基己酯、辛基十二烷醇、椰油酸乙基己酯、己二酸二丁酯中的一个或多个，优选地丁二醇、碳酸二辛酯、苯甲酸苯乙酯、苯甲酸C12-C15烷基酯、碳酸辛酯、癸酸/辛酸甘油三酯中的一个或多个，最优选地丁二醇、苯甲酸苯乙酯和苯甲酸C12-C15烷基酯。
10.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物还包含乙醇、苯氧乙醇和乙基己基甘油中的一种或多种，优选地苯氧乙醇和乙基己基甘油中的一种或多种。
11.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物还包含黄原胶、交联丙烯酸酯/丙烯酸C10-C30烷基酯聚合物、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物中的一种或多种，优选地黄原胶。
12.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物还包含山萮醇、鲸蜡醇、鲸蜡硬脂醇、硬脂醇和硬脂酸甘油酯中的一种或多种，优选地山萮醇、硬脂醇和鲸蜡硬脂醇。
13.根据前述权利要求中任一项所述的防晒组合物，其中所述组合物具有至少20的SPF。
14.一种在施用于皮肤之前和/或之后改善防晒组合物的感官和/或美学性质的方法，所述方法包括以下步骤：向所述组合物中掺入(i)双乙基己氧基苯酚甲氧基苯基三嗪和(ii)两种或更多种颜料UV过滤剂作为仅有的UV过滤剂物质。
15.双乙基己氧基苯酚甲氧基苯基三嗪用于降低防晒组合物中包含的两种或更多种颜料UV过滤剂在施用于皮肤后的增白效果的用途。
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