CN116889602A - A topical Chinese medicinal composition for treating synovitis and tenosynovitis, and its preparation method - Google Patents
A topical Chinese medicinal composition for treating synovitis and tenosynovitis, and its preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The application provides an external traditional Chinese medicine composition for treating synovitis and tenosynovitis and a preparation method thereof, wherein the external traditional Chinese medicine composition comprises the following raw materials: radix Aconiti Preparata, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, ningpo Yam rhizome, cortex Erythrinae, radix Angelicae sinensis, radix Paeoniae Rubra, radix Angelicae Dahuricae, radix Ampelopsis, fructus forsythiae, semen Momordicae, radix Clematidis, radix Pulsatillae, fructus Gleditsiae Abnormalis, herba Speranskiae Tuberculatae, flos Campsis, carthami flos, cortex Cinnamomi, semen Sinapis Albae, caulis Sinapis Albae, zaocys, scolopendra, camphora, myrrha, folium Bulbophylli Radicis, olibanum, herba Schizonepetae. The external traditional Chinese medicine composition disclosed by the application is simple in preparation process, combines the medicines, has the effects of clearing damp, removing arthralgia, dredging collaterals, relieving pain, relaxing tendons, activating blood, warming and dredging channels, resisting inflammation and relieving pain, and has very remarkable treatment effects on synovitis and tenosynovitis.
Description
Technical Field
The application belongs to the technical field of traditional Chinese medicines, and in particular relates to an external traditional Chinese medicine composition for treating synovitis and tenosynovitis and a preparation method thereof.
Background
Synovitis (synovitis) is a clinical common orthopedic disease, mainly an arthropathy that causes inflammation due to the stimulation of synovium, and causes secretion imbalance to form effusion. Such as articular cartilage injury, intra-articular fracture, dislocation, ligament injury, joint freeness, etc., can cause traumatic inflammation of synovium. Tenosynovitis, or stenosed tenosynovitis, refers to an inflammatory change of tendon, such as congestion, increased exudation, and thickening of synovial membrane, caused by excessive friction or repeated abrasion of tendon in tendon sheath for a long time, and causes thickening, adhesion, or stenosis of tendon sheath wall, and diseases manifested by pain, elastic sound, and limited movement of tendon, which may occur in the finger, toe, wrist, ankle, and shoulder.
Synovitis belongs to the category of "arthralgia syndrome" in traditional Chinese medicine because the main symptom is pain; tenosynovitis belongs to the category of 'muscle paralysis' and 'muscle injury' in traditional Chinese medicine. The traditional Chinese medicine considers that synovitis is a condition of stagnation of damp turbidity and phlegm stasis; tenosynovitis is caused by strain injury of tendons, cold dampness invasion of collaterals, obstruction of meridians, unsmooth qi and blood circulation, qi stagnation and blood stasis. In general, synovitis and tenosynovitis are both in the category of "arthromyodynia" in TCM. The traditional Chinese medicine has various methods for treating synovitis and tenosynovitis, such as oral traditional Chinese medicine decoction, traditional Chinese medicine external application, traditional Chinese medicine hot compress, traditional Chinese medicine fumigation, acupuncture, cupping, massage, moxibustion, medicinal liquor and the like, and the treatment methods have certain curative effects, but are poor in taste and bitter in taste, so that patients cannot accept the traditional Chinese medicine, the treatment modes are inconvenient, such as fumigation, acupuncture, cupping, massage and the like, and more specialized people are required to operate and treat the traditional Chinese medicine, and time and labor are wasted. Therefore, how to provide an external traditional Chinese medicine composition for treating synovitis and tenosynovitis, which has definite curative effect, convenient use, safety and no toxic or side effect, is a problem to be solved by the technicians in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the application aims to provide an external traditional Chinese medicine composition and a preparation method and application thereof, in particular to an external traditional Chinese medicine composition for treating synovitis and tenosynovitis and a preparation method and application thereof.
In order to achieve the aim of the application, the application adopts the following technical scheme:
in a first aspect, the application provides an external traditional Chinese medicine composition for treating synovitis and tenosynovitis, which comprises the following raw materials: 10-30 parts of prepared common monkshood mother root, 10-30 parts of szechuan lovage rhizome, 5-25 parts of rhubarb, 5-25 parts of Ningpo Yam rhizome, 10-30 parts of erythrina bark, 10-30 parts of Chinese angelica, 3-20 parts of red paeony root, 3-20 parts of dahurian angelica root, 3-20 parts of Japanese ampelopsis root, 10-20 parts of weeping forsythia, 3-20 parts of Momordica grossedentata, 10-30 parts of Chinese clematis root, 5-25 parts of Chinese pulsatilla root, 5-15 parts of Chinese honeylocust fruit, 5-15 parts of garden balsam stem, 10-30 parts of campsis flower, 5-25 parts of safflower, 5-25 parts of cassia bark, 5-20 parts of white mustard seed, 5-20 parts of common sargentgloryvine stem, 5-25 parts of black snake, 3-12 parts of centipede, 3-12 parts of camphor, 5-20 parts of myrrh, 15-30 parts of cloth slag leaf, 5-20 parts of frankincense and 5-20 parts of Chinese thorn.
Preferably, the external traditional Chinese medicine composition comprises the following raw materials: 15-30 parts of prepared common monkshood mother root, 15-25 parts of szechuan lovage rhizome, 10-20 parts of rhubarb, 10-25 parts of Ningpo yam rhizome, 15-30 parts of erythrina bark, 15-25 parts of Chinese angelica, 5-15 parts of red paeony root, 5-15 parts of dahurian angelica root, 5-15 parts of Japanese ampelopsis root, 12-18 parts of weeping forsythia, 5-15 parts of Momordica grossedentata, 15-30 parts of Chinese clematis root, 10-25 parts of Chinese pulsatilla root, 7-15 parts of Chinese honeylocust fruit, 7-15 parts of garden balsam stem, 15-30 parts of campsis grandiflora, 10-22 parts of safflower, 10-22 parts of cassia bark, 7-18 parts of white mustard seed, 7-18 parts of caulis sinomenii, 10-25 parts of black snake, 5-10 parts of centipede, 5-10 parts of camphor, 8-18 parts of myrrh, 20-25 parts of folium bubali, 10-20 parts of frankincense and 10-20 parts of Chinese thorn.
More preferably, the external traditional Chinese medicine composition comprises the following raw materials: 30 parts of prepared common monkshood mother root, 22 parts of szechuan lovage rhizome, 12 parts of rhubarb, 18 parts of Ningpo yam rhizome, 30 parts of erythrina bark, 25 parts of Chinese angelica, 12 parts of red paeony root, 10 parts of dahurian angelica root, 10 parts of Japanese ampelopsis root, 15 parts of weeping forsythiae capsule, 12 parts of Momordica grosvenori, 25 parts of Chinese clematis, 17 parts of Chinese pulsatilla root, 9 parts of Chinese honeylocust fruit, 10 parts of garden balsam stem, 30 parts of campsis flower, 20 parts of safflower, 15 parts of cassia bark, 10 parts of white mustard seed, 10 parts of caulis sinomenii, 14 parts of black snake, 8 parts of centipede, 6 parts of camphor, 13 parts of myrrh, 22 parts of cloth residue leaf, 15 parts of frankincense and 15 parts of golden larch.
In a second aspect, the application provides a preparation method of the external traditional Chinese medicine composition, which comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight 5-12 times of that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, performing ultrasonic extraction on the traditional Chinese medicine powder for 1-6 h, and filtering to obtain filtrate and filter residues for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding 85% ethanol solution with the weight 2-3 times of the coarse powder for soaking 1-3 h, fully expanding the coarse powder of the medicinal materials, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 2-3 times, filling the percolator with the filter residue obtained in the step S2 for 1-2 times, compacting by wood sticks after filling each time, slowly adding 85% ethanol solution from the upper part of the percolator, percolating and extracting 2-6 h, and collecting percolate for standby;
s4, combining the filtrate obtained in the step S2 and the percolate obtained in the step S3, heating and concentrating to 40-60% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Further, the ethanol solution in step S2 was used in an amount of 8 times, and the extraction time was 3.5. 3.5 h.
Further, the percolation extraction time in the step S3 is 4h, and the concentration volume in the step S4 is 50% of the original volume.
In a third aspect, the application provides an application of the external traditional Chinese medicine composition in preparing medicines for treating synovitis and tenosynovitis.
All traditional Chinese medicines related by the application can be purchased from general traditional Chinese medicine stores, and the specification of the traditional Chinese medicine meets the standards of Chinese pharmacopoeia.
Wherein the radix Aconiti Preparata is processed product of dried parent root of Aconitum carmichaeli Aconitum carmichaeli Debx. Has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain.
Wherein the rhizoma Ligustici Chuanxiong is rhizome of Umbelliferae herb Ligusticum chuanxiong Hort. Has effects of activating qi-flowing, resolving stagnation, eliminating dampness, promoting blood circulation and relieving pain. For headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stasis, block pain, carbuncle, cellulitis and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, chest and hypochondrium pain, traumatic injury, headache, and rheumatalgia.
Wherein the radix et rhizoma Rhei is dried root and rhizome of Rheum palmatum L, rheum tanguticum Rheum tanguticum Maximex Balf or Rheum officinale Rheum officinale Baill of Polygonaceae. Has effects of purging heat, removing intestinal stasis, cooling blood, removing toxic substance, and dredging channels. Can be used for treating constipation due to excessive heat, abdominal pain due to stagnation, diarrhea, jaundice due to damp-heat, hematemesis, conjunctival congestion, pharyngeal swelling, intestinal abscess, abdominal pain, carbuncle, furuncle, blood stasis, amenorrhea, traumatic injury, and external scald due to pathogenic fire and water; upper gastrointestinal hemorrhage. The excessive heat and toxicity of the upper energizer and blood system of the wine is Huang Shanqing. Can be used for treating conjunctival congestion, pharyngeal swelling, and gingival swelling and pain. The cooked rhubarb has the effects of purging the lower power and purging the pathogenic fire and removing toxin. Can be used for treating skin and external diseases due to pathogenic fire.
Wherein Dioscorea nipponica Makino is Dioscorea nipponica Makino Dioscorea nipponica Makino of Dioscorea of Dioscoreaceae, and is administered by root-like stem. Has effects of promoting blood circulation, relaxing muscles and tendons, resolving food stagnation, promoting diuresis, eliminating phlegm, and preventing malaria. For arthralgia due to wind-cold-dampness, chronic tracheitis, dyspepsia, strain sprain, malaria, and carbuncle.
Wherein the Erythrina bark is bark or root bark of Erythrina indica lam. Has effects of dispelling pathogenic wind and dampness, relaxing muscles and tendons, and dredging collaterals. Can be used for treating rheumatism, numbness, lumbago, skelalgia, bone and muscle pain, and traumatic injury; it is indicated for various stubborn dermatitis by external application.
Wherein the radix Angelicae sinensis is dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating sallow complexion due to blood deficiency, dizziness, palpitation, menoxenia, amenorrhea, dysmenorrhea, abdominal pain due to deficiency-cold, constipation due to intestinal dryness, rheumatalgia, traumatic injury, carbuncle, and pyocutaneous disease. The wine angelica can promote blood circulation and promote menstruation. Can be used for treating amenorrhea dysmenorrhea, rheumatalgia, traumatic injury.
Wherein the radix Paeoniae Rubra is dried root of Pall of Paulliniaceae or Paeonia veitchii Lynch of radix Paeoniae Rubra. Has effects of clearing heat, cooling blood, removing blood stasis and relieving pain. Can be used for treating toxic heat, speckle, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver Yu Xie pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling and ulcer.
Wherein the radix Angelicae Dahuricae is dried root of radix Angelicae Dahuricae Angelica dahurica (Fisch. Ex Hoffm.) or radix Angelicae Dahuricae Angelica dahurica (Fisch. Ex Hoffm.) of the family Agaricaceae. Has effects of dispelling pathogenic wind, removing dampness, inducing resuscitation, relieving pain, relieving swelling, and expelling pus. Can be used for treating common cold, headache, bone pain of eyebrow, nasal obstruction, nasosinusitis, toothache, leucorrhea, and sore pain.
Wherein the radix Ampelopsis is dried root tuber of Ampelopsis japonica Ampelopsis japonica (thunder.) Makino of Vitaceae. Has effects of clearing heat and detoxicating, resolving carbuncle and resolving hard mass. Can be used for treating carbuncle, furuncle, scrofula, scald due to water and fire.
Wherein the fructus forsythiae is dried fruit of Forsythia suspensa Forsythia suspensa (thunder.) Vahl of Oleaceae. Has effects of clearing heat and detoxicating, detumescence and resolving hard mass. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early stage of warm diseases, warm syndrome, hyperpyrexia, polydipsia, unconsciousness, speckle, and stranguria due to heat.
Wherein the Momordica cochinchinensis is dried mature seed of Spreng of Momordica cochinchinensis Momordica cochinchinensis (Lour.). Has effects of resolving hard mass, detumescence, eliminating toxic materials and treating sore. Can be used for treating pyocutaneous disease, toxic swelling, acute mastitis, scrofula, anal fistula, tinea corporis, and tinea corporis.
Wherein the radix Clematidis is root and rhizome of Clematis Clematidis chinensis Osbeck of Ranunculaceae, clematis C. Hexapetalapall or Clematis C. Manshuricarupr. Has effects of dispelling pathogenic wind and removing dampness, and dredging channels and collaterals. Can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexing and extending.
Wherein the radix Pulsatillae is dried root of Regel of Pulsatillae Pulsatilla chinensis (Bge.) belonging to Ranunculaceae. Has effects of clearing heat and detoxicating, cooling blood and relieving dysentery. Is used for treating dysentery with heat toxin and bloody stool, pruritus vulvae, leukorrhagia, and amebic dysentery.
Wherein the fructus Gleditsiae Abnormalis is mature fruit of Gleditsia sinensis Gleditsia sinensis lam. Has effects of inducing resuscitation, eliminating phlegm, resolving hard mass, relieving swelling, moistening dryness, and relieving constipation. Is used for inducing resuscitation, dispelling pathogenic wind, clearing heat, eliminating phlegm, removing dampness, removing dirt, resolving hard mass, dispersing stagnancy, eliminating swelling, and sterilizing.
Wherein the herba speranskiae tuberculatae is whole plant of Euphorbiaceae family Euphorbia genus plant Euphorbia lathyris Speranskia tuberculata (Bunge) Baill, garden balsam family herbal garden balsam Impatiens balsamina L, bignoniaceae family Artemisia genus plant Artemisia carob Incarvillea sinensis lam, leguminosae family Vicia amoena Fisch. Whole plant and Ericaceae family Callicarpa genus plant Phyllanthus yunnanensis Gaultheria yunnanensis (Franch.) Red. Has effects of dispelling pathogenic wind, removing dampness, removing toxic substances and relieving pain. Can be used for treating rheumatic arthralgia; it is indicated for sores and ulcers and other sores with toxic swelling.
Wherein the Campsis grandiflora is Chai Weike dried flowers and roots of Campsis grandiflora Campsis grandiflora (thunder.) K.Schum or Campsis grandiflora (L.) Seem. Has effects in cooling blood, dispelling blood stasis, dispelling pathogenic wind, promoting blood circulation, removing blood stasis, removing toxic materials, and relieving swelling. Can be used for treating menoxenia, amenorrhea, abdominal mass, puerperal lactoma, rubella redness, skin pruritus, acne, rheumatalgia, traumatic injury, fracture, dislocation, and acute gastroenteritis.
Wherein the safflower is dried flower of Compositae plant safflower Carthamus tinctorius L. Has effects of promoting blood circulation, dredging channels, removing blood stasis, and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochia, mass, traumatic injury, and swelling and pain of pyocutaneous disease.
Wherein cortex Cinnamomi is dried twig of Cinnamomum cassia Cinnamomum cassia Presl belonging to Lauraceae. Has effects of inducing sweat, relieving muscle, warming and activating meridian, supporting yang, activating qi-flowing, and calming the pulse. Can be used for treating common cold due to wind-cold, abdominal pain, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, and dolphin.
Wherein the semen Sinapis Albae is seed of Brassica alba L of Brassicaceae. Has effects of activating qi-flowing, eliminating phlegm, warming spleen and stomach, dispelling cold, dredging collaterals and relieving pain. For cough and asthma due to phlegm-fluid retention, fullness and pain in chest and hypochondrium, regurgitation and vomiting, aphasia due to apoplexy, arthralgia and numbness of limbs, tinea pedis, cellulitis, swelling and pain due to traumatic injury.
Wherein caulis Sinomenii is dried rattan of Sinomenii (Thunb.) of Menispermaceae family of plant Sinomenii Sinomenium acutum (Thunb.) of Rehd et Wils. Has effects of dispelling pathogenic wind and dampness, dredging channels and collaterals, and promoting urination. Can be used for treating rheumatalgia, joint swelling, and paralysis and pruritus.
Wherein the Zaocys is the whole viscera removed of Zaocys belonging to the family Zaocysaceae. Has effects of dispelling pathogenic wind and removing dampness, and dredging channels and collaterals. It can be used for treating intractable arthralgia due to wind-dampness, skin disorder, bone tuberculosis, joint tuberculosis, rubella, scabies, leprosy, tetanus, and poliomyelitis.
Wherein the Scolopendra is dried body of Scolopendra (Scolopendra, scolopendra subspinipes mutilans (L.) pers. Scolopendra subspinipes mutilans L. Koch). Has effects of calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain. Can be used for treating infantile convulsion, apoplexy, facial distortion, hemiplegia, tetanus, rheumatism, pyocutaneous disease, scrofula, and venomous snake bite.
Wherein the camphor is granular crystal obtained by distilling root, branch, leaf and waste material of Cinnamomum camphora Cinnamomum camphora (L.) Presl. Has effects of inducing resuscitation, relieving pain, promoting diuresis and killing parasite. Can be used for treating vomiting and diarrhea due to cold dampness, and stomach and abdomen pain; it is used for treating scabies, tinea, and caries.
Wherein the myrrh is an oleoresin exuded from the bark of the trunk of a plant of the genus myrrh of the family Burseraceae, the genus myrrh, commiphora myrrha Engl [ c. Molmol Engl ]. Has effects of dispelling blood stasis, relieving swelling and relieving pain. For traumatic injury, golden sore, tendons and bones, pain in heart and abdomen, abdominal mass, amenorrhea, carbuncle, abscess, swelling and pain, anal fistula, and eye injury.
Wherein the leaf of Bu Zhi Ye is leaf of Microcos paniculata of Bu genus of Tiliaceae family. Has effects of clearing summer-heat, resolving food stagnation, and eliminating phlegm. Can be used for treating common cold, heatstroke, food stagnation, dyspepsia, and diarrhea.
Wherein the Olibanum is Boswellia carterii Birdw of Boswellia carterii (Boswellia carterii) of genus Boswellia of family Oleraceae [ B.sacra Fluek. ], boswellia carterii B.bhawdajiana birdw. And Boswellia carterii B.neglecta M.Moore, etc., and is administered by using oleoresin exuded from the wound of the trunk bark. Has effects of promoting blood circulation and relieving pain. Can be used for treating pain in heart and abdomen, spasm of tendons and vessels, traumatic injury, sore, carbuncle, and swelling and pain; for external use, detumescence and granulation promoting are provided.
Wherein the Jingmi is the dry aerial part of Schizonepeta Schizonepeta tenuifolia Briq. Has effects of relieving exterior syndrome, dispelling pathogenic wind, and promoting eruption. Can be used for treating common cold, headache, measles, rubella, and skin and external infection. Stir-baked charcoal to treat hematochezia, metrorrhagia and metrostaxis and postpartum anemic fainting.
The beneficial effects of the application are as follows: the traditional Chinese medicine considers synovitis and tenosynovitis, belongs to the category of arthralgia syndrome in the traditional Chinese medicine, and clinically generally takes damp-dispelling arthralgia-eliminating, vein relaxing pain-relieving, tendons relaxing, blood circulation activating, meridian warming and vein relaxing as treatment rules. The application relates to an external traditional Chinese medicine composition, which takes erythrina bark, campsis grandiflora and clematis root as monarch drugs and has the effects of dispelling wind and removing dampness, relaxing tendons and dredging collaterals, cooling blood and removing blood stasis, and detoxifying and relieving swelling; the effects of dispelling wind, removing dampness, warming channels, relieving pain, clearing heat and detoxicating by taking the ligusticum wallichii, prepared radix aconiti, pulsatilla chinensis, garden balsam stem, folium gleditsiae and rheum officinale as ministerial drugs are further enhanced; the traditional Chinese medicine composition has the effects of removing necrotic tissue, promoting granulation, relieving swelling and pain, inducing diuresis, relieving swelling, strengthening muscle and tendon and the like while taking Ningpo Yam rhizome, chinese angelica, red peony root, fineleaf schizonepeta herb, chinese honeylocust fruit, cassia twig, dahurian angelica root, japanese ampelopsis root, frankincense, myrrh and weeping forsythiae capsule as adjuvant drugs and taking Momordica Charantia seed, safflower, white mustard seed, caulis Sinomenii, zaocys, centipede and camphor as guiding drugs, regulating the effects of dispelling wind, dredging collaterals, tonifying kidney and strengthening tendons. The medicines are combined to play roles of dispelling dampness, removing arthralgia, dredging collaterals, relieving pain, relaxing tendons, activating blood, warming and activating meridians, resisting inflammation and easing pain, and has very remarkable treatment effect on synovitis and tenosynovitis.
Detailed Description
For a better understanding of the present application, embodiments of the present application are described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present application and should not be construed as limiting the scope of the present application.
Example 1:
a topical Chinese medicinal composition for treating synovitis and tenosynovitis comprises the following raw materials: 30 parts of prepared common monkshood mother root, 30 parts of szechuan lovage rhizome, 25 parts of rhubarb, 25 parts of Ningpo yam rhizome, 30 parts of erythrina bark, 30 parts of Chinese angelica, 20 parts of red paeony root, 20 parts of dahurian angelica root, 20 parts of Japanese ampelopsis root, 20 parts of weeping forsythiae capsule, 20 parts of Momordica grosvenori, 30 parts of Chinese clematis, 25 parts of Chinese pulsatilla root, 15 parts of Chinese honeylocust fruit, 15 parts of garden balsam stem, 30 parts of campsis flower, 25 parts of safflower, 25 parts of cassia bark, 20 parts of white mustard seed, 20 parts of caulis sinomenii, 25 parts of black snake, 12 parts of centipede, 12 parts of camphor, 20 parts of myrrh, 30 parts of cloth residue leaf, 20 parts of frankincense and 20 parts of golden larch.
The preparation method of the external traditional Chinese medicine composition comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight of 12 times of that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, performing ultrasonic extraction on the traditional Chinese medicine powder to obtain 6 h, and filtering to obtain filtrate and filter residues for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding an 85% ethanol solution with 3 times of the weight of the coarse powder for soaking 3 h, fully expanding the coarse powder of the medicinal materials, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 3 times, filling the percolator with the filter residue obtained in the step S2 for 2 times, compacting by using a stick after filling, slowly adding the 85% ethanol solution from the upper part of the percolator, percolating and extracting 6 h, and collecting percolate for standby;
s4, combining the filtrate obtained in the step S2 with the percolate obtained in the step S3, heating and concentrating to 60% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Example 2:
a topical Chinese medicinal composition for treating synovitis and tenosynovitis comprises the following raw materials: 10 parts of prepared common monkshood mother root, 10 parts of szechuan lovage rhizome, 5 parts of rhubarb, 5 parts of Ningpo yam rhizome, 10 parts of erythrina bark, 10 parts of Chinese angelica, 3 parts of red paeony root, 3 parts of dahurian angelica root, 3 parts of Japanese ampelopsis root, 10 parts of weeping forsythiae capsule, 3 parts of Momordica grosvenori, 10 parts of Chinese clematis, 5 parts of Chinese pulsatilla root, 5 parts of Chinese honeylocust fruit, 5 parts of garden balsam stem, 10 parts of campsis flower, 5 parts of safflower, 5 parts of cassia bark, 5 parts of white mustard seed, 5 parts of caulis sinomenii, 5 parts of black snake, 3 parts of centipede, 3 parts of camphor, 5 parts of myrrh, 15 parts of cloth residue leaf, 5 parts of frankincense and 5 parts of golden larch.
The preparation method of the external traditional Chinese medicine composition comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight 5 times of that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, ultrasonically extracting for 1.5 hours, and filtering to obtain filtrate and filter residue for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding 85% ethanol solution with the weight 2 times of the coarse powder to infiltrate 1 h, fully expanding the coarse powder, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 2 times, filling the percolator with the filter residue obtained in the step S2 for 1 time, compacting by using a stick after filling, slowly adding 85% ethanol solution from the upper part of the percolator, percolating and extracting 2 h, and collecting percolate for standby;
s4, combining the filtrate obtained in the step S2 and the percolate obtained in the step S3, heating and concentrating to 40% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Example 3:
a topical Chinese medicinal composition for treating synovitis and tenosynovitis comprises the following raw materials: 20 parts of prepared common monkshood mother root, 20 parts of szechuan lovage rhizome, 15 parts of rhubarb, 10 parts of Ningpo Yam rhizome, 25 parts of erythrina bark, 22 parts of Chinese angelica, 11 parts of red paeony root, 13 parts of dahurian angelica root, 9 parts of Japanese ampelopsis root, 11 parts of weeping forsythiae capsule, 8 parts of Momordica grosvenori, 25 parts of Chinese clematis, 17 parts of Chinese pulsatilla root, 6 parts of Chinese honeylocust fruit, 11 parts of garden balsam stem, 25 parts of campsis flower, 8 parts of safflower, 10 parts of cassia bark, 7 parts of white mustard seed, 15 parts of caulis sinomenii, 13 parts of black snake, 4 parts of centipede, 5 parts of camphor, 11 parts of myrrh, 26 parts of folium buergeriae, 11 parts of frankincense and 6 parts of golden larch.
The preparation method of the external traditional Chinese medicine composition comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight being 7 times of that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, performing ultrasonic extraction on the traditional Chinese medicine powder to obtain 4.5 h, and filtering the obtained product to obtain filtrate and filter residues for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding 85% ethanol solution with the weight 2 times of the coarse powder for soaking 2.5 and h, fully expanding the coarse powder, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 3 times, filling the percolator with the filter residue obtained in the step S2 for 2 times, compacting by using a stick after each filling, slowly adding 85% ethanol solution from the upper part of the percolator, percolating to extract 3.5 h, and collecting percolate for later use;
s4, combining the filtrate obtained in the step S2 and the percolate obtained in the step S3, heating and concentrating to 45% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Example 4:
a topical Chinese medicinal composition for treating synovitis and tenosynovitis comprises the following raw materials: 28 parts of prepared common monkshood mother root, 14 parts of szechuan lovage rhizome, 15 parts of rhubarb, 16 parts of Ningpo Yam rhizome, 28 parts of erythrina bark, 22 parts of Chinese angelica, 11 parts of red paeony root, 6 parts of dahurian angelica root, 6 parts of Japanese ampelopsis root, 14 parts of weeping forsythiae capsule, 11 parts of semen momordicae, 28 parts of Chinese clematis, 14 parts of Chinese pulsatilla root, 9 parts of Chinese honeylocust fruit, 10 parts of garden balsam stem, 28 parts of campsis flower, 14 parts of safflower, 17 parts of cassia bark, 14 parts of white mustard seed, 16 parts of common sargentgloryvine stem, 10 parts of black snake, 6 parts of centipede, 7 parts of camphor, 15 parts of myrrh, 20 parts of cloth residue leaf, 15 parts of frankincense and 11 parts of golden larch.
The preparation method of the external traditional Chinese medicine composition comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight being 11 times that of the traditional Chinese medicine powder obtained in the step S1, performing ultrasonic extraction on the traditional Chinese medicine powder to obtain 5.5 h, and filtering to obtain filtrate and filter residue for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding 85% ethanol solution with 3 times of the weight of the coarse powder for soaking 2 h, fully expanding the coarse powder, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 2 times, filling the percolator with the filter residue obtained in the step S2 for 2 times, compacting by using a stick after filling, slowly adding 85% ethanol solution from the upper part of the percolator, percolating and extracting 5.5 h, and collecting percolate for later use;
s4, combining the filtrate obtained in the step S2 with the percolate obtained in the step S3, heating and concentrating to 55% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Example 5:
a topical Chinese medicinal composition for treating synovitis and tenosynovitis comprises the following raw materials: 30 parts of prepared common monkshood mother root, 22 parts of szechuan lovage rhizome, 12 parts of rhubarb, 18 parts of Ningpo yam rhizome, 30 parts of erythrina bark, 25 parts of Chinese angelica, 12 parts of red paeony root, 10 parts of dahurian angelica root, 10 parts of Japanese ampelopsis root, 15 parts of weeping forsythiae capsule, 12 parts of Momordica grosvenori, 25 parts of Chinese clematis, 17 parts of Chinese pulsatilla root, 9 parts of Chinese honeylocust fruit, 10 parts of garden balsam stem, 30 parts of campsis flower, 20 parts of safflower, 15 parts of cassia bark, 10 parts of white mustard seed, 10 parts of caulis sinomenii, 14 parts of black snake, 8 parts of centipede, 6 parts of camphor, 13 parts of myrrh, 22 parts of cloth residue leaf, 15 parts of frankincense and 15 parts of golden larch.
The preparation method of the external traditional Chinese medicine composition comprises the following steps:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight being 8 times that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, performing ultrasonic extraction on the traditional Chinese medicine powder to obtain 3.5 h, and filtering to obtain filtrate and filter residues for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding an 85% ethanol solution with 3 times of the weight of the coarse powder for soaking 2.5 and h, fully expanding the coarse powder, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 3 times, filling the percolator with the filter residue obtained in the step S2 for 2 times, compacting by using a stick after each filling, slowly adding the 85% ethanol solution from the upper part of the percolator, percolating and extracting for 4 hours, and collecting percolate for standby;
s4, combining the filtrate obtained in the step S2 with the percolate obtained in the step S3, heating and concentrating to 50% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
Example 6: influence of the external traditional Chinese medicine composition on type II collagen-induced arthritis rat synovitis
(1) Experimental animals: clean grade Wistar rats 30, male, 2-3 months old, weight 180-220 g purchased from Shanghai laboratory animal company of liability.
(2) Experimental grouping and experimental method: the 36 rats were randomly divided into 5 groups of 6 rats, each of which was a normal group, a model group, a low dose treatment group, a medium dose treatment group, and a high dose treatment group. 0.1mmol +.2 in bovine type II collagenL acetic acid was thoroughly mixed and emulsified with Freund's complete adjuvant 1:1 at a ratio of 2mg/mL, and injected into the tail root of the remaining groups of rats except the normal group (each injection was 0.2 mL). Arthritis was induced 11-16 days after collagen immunization, and inflammation after onset lasted 3-4 weeks. Administration was started on day 10 after molding, and the abdomen and leg of rats in the normal group, model group, low dose treatment group, medium dose treatment group, and high dose treatment group were dehaired over an abdomen dehairing range of about 2×3 cm before administration 2 The external Chinese medicinal composition prepared in example 5 was administered to the ankle, knee and abdomen dehairing sites of each rat at a dose of 1.0 g/kg, 2.0g/kg, 4.0 g/kg, and normal and model groups with 4.0 g/kg physiological saline, respectively, and the composition was applied to the ankle and abdomen dehairing sites of each rat to be fully absorbed and continuously administered at a dose of 10 d each time in the morning and evening. After the last administration of 1 h, the rats were sacrificed at the broken ends, joint synovium was separated, HE pathological sections were performed on the synovium, and the effect on inflammatory cell infiltration, giant phaga type a cell proliferation, synovial hyperplasia was determined.
(3) Experimental results: the experimental results are shown in Table 1, the external traditional Chinese medicine composition has obvious inhibition effect on synovial giant phaga A cell proliferation and synovial proliferation at low, medium and high doses, and the high dose group effect is the best.
Table 1 effect on arthritic rat synovial inflammation pathology score (mean ± standard deviation, n=6)
Note that: compared with the blank group, the # P is less than 0.05, and the # P is less than 0.01; p < 0.05, P < 0.01 compared to model group.
Example 7: the externally applied traditional Chinese medicine composition has the clinical treatment effect on tenosynovitis
(1) General data: during the period of 6 months 2022 to 12 months 2022, 50 cases of tenosynovitis were selected. Of these, 10 men and 40 women; the age was 69 years at maximum, 13 years at minimum, and the average age (45.80 ±9.63); the course of the disease is 1-45 months, and the average course of the disease (10.02+ -6.75) is one month.
(2) Diagnostic criteria: reference is made to the "practical bone science" published by the national administration of traditional Chinese medicine in 1994, the "diagnostic and therapeutic Standard for traditional Chinese medical Condition" in 2016, li Maohua et al. Grading standard: reference is made to the techniques for the treatment of clinical pain. Inclusion criteria: 1. meets the diagnosis standard of tenosynovitis of the finger; 2. age not less than 12 years, 3, no related treatment such as acupuncture, sealing, small needle knife, wax therapy and the like in about 1 month, 4, informing the patient and family members of the interest and the fraud of the study and signing an informed consent. Exclusion criteria: 1. pregnant women or women in lactation period, 2 patients with infectious diseases and coagulation dysfunction, 3 patients allergic to the drugs adopted in the study, and 4 patients with serious cardiovascular and cerebrovascular diseases.
(3) The treatment method comprises the following steps: the above 50 patients were divided into 2 groups at random according to tenosynovitis severity, and 25 persons in each group were recorded as a control group and an experimental group. The control group orally administrates the lamiophlomis rotata capsules 3 granules at a time, 3 times a day, and 7 days as a treatment course. The composition for external use prepared in example 5 of the present application was administered to the affected part in an experimental group, and applied 1 time a day in the morning and evening for 7 consecutive days as a treatment course.
(4) And (3) observing the indexes:
1) Pain degree assessment: the pain level of the patient was assessed using a visual analog scale (Visual Analogue Scale, VAS) score. A transverse line of 10 cm was drawn on the sheet, with one end of the transverse line being 0, indicating no pain was felt, and the other end being 10, indicating the greatest pain that was intolerable, and the patient was given a mark on the transverse line to indicate the extent of pain based on self-perception. The results are shown in Table 2.
Table 22 group of finger sphingosine patients before and after treatment VAS score comparison (mean.+ -. Standard deviation)
Note that: compared with the prior treatment, the, # P is less than 0.05, and the, # P is less than 0.01; p < 0.05, P < 0.01 compared to the control group.
2) Curative effect judgment criteria: the curative effect evaluation standard about finger tenosynovitis is formulated by referring to the practical bone science and the traditional Chinese medicine disease diagnosis curative effect standard. The treatment efficacy was assessed in group 2 patients at follow-up after 2 treatment sessions, respectively. The traditional Chinese medicine composition has the advantages of curing the pain of the affected finger completely disappearing, ensuring normal movement of the metacarpophalangeal joints, avoiding the phenomena of ringing and twisting locks, improving the pain of the affected finger basically disappearing, relieving the tenderness before, ensuring the metacarpophalangeal joints to bounce or have the phenomena of ringing but not twisting locks, and being ineffective, and ensuring that various symptoms of the affected finger are not changed. Total effective rate= (number of cured cases + number of improved cases)/total number of cases 100%, cure rate = number of cured cases/total number of cases 100%. The results are shown in Table 3.
Table 3 2 clinical efficacy comparison of patients with finger sphingosine (example (%))
From tables 2 and 3, it can be seen that the VAS score is significantly reduced after treatment in the experimental group and the total effective rate is higher compared with the control group, which indicates that the external traditional Chinese medicine composition of the application has better treatment effect on finger tenosynovitis.
In conclusion, from experimental results, the low, medium and high dose groups of the external traditional Chinese medicine composition have remarkable treatment effects on synovitis and tenosynovitis, and the external traditional Chinese medicine composition has definite anti-inflammatory, detumescence and analgesic effects, can be used for treating synovitis and tenosynovitis, and is convenient to use.
The applicant states that the present application is described by the above examples as an external Chinese medicinal composition for treating synovitis and tenosynovitis and a preparation method thereof, but the present application is not limited to the above examples, i.e., it does not mean that the present application must be practiced by the above examples. It should be apparent to those skilled in the art that any modification of the present application, equivalent substitution of raw materials for the product of the present application, addition of auxiliary components, selection of specific modes, etc., falls within the scope of the present application and the scope of disclosure.
The preferred embodiments of the present application have been described in detail above, but the present application is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solution of the present application within the scope of the technical concept of the present application, and all the simple modifications belong to the protection scope of the present application.
In addition, the specific features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described further.
Claims (7)
1. An external traditional Chinese medicine composition for treating synovitis and tenosynovitis is characterized by comprising the following raw materials: 10-30 parts of prepared common monkshood mother root, 10-30 parts of szechuan lovage rhizome, 5-25 parts of rhubarb, 5-25 parts of Ningpo Yam rhizome, 10-30 parts of erythrina bark, 10-30 parts of Chinese angelica, 3-20 parts of red paeony root, 3-20 parts of dahurian angelica root, 3-20 parts of Japanese ampelopsis root, 10-20 parts of weeping forsythia, 3-20 parts of Momordica grossedentata, 10-30 parts of Chinese clematis root, 5-25 parts of Chinese pulsatilla root, 5-15 parts of Chinese honeylocust fruit, 5-15 parts of garden balsam stem, 10-30 parts of campsis flower, 5-25 parts of safflower, 5-25 parts of cassia bark, 5-20 parts of white mustard seed, 5-20 parts of common sargentgloryvine stem, 5-25 parts of black snake, 3-12 parts of centipede, 3-12 parts of camphor, 5-20 parts of myrrh, 15-30 parts of cloth slag leaf, 5-20 parts of frankincense and 5-20 parts of Chinese thorn.
2. The external traditional Chinese medicine composition according to claim 1, which is composed of the following raw materials: 15-30 parts of prepared common monkshood mother root, 15-25 parts of szechuan lovage rhizome, 10-20 parts of rhubarb, 10-25 parts of Ningpo yam rhizome, 15-30 parts of erythrina bark, 15-25 parts of Chinese angelica, 5-15 parts of red paeony root, 5-15 parts of dahurian angelica root, 5-15 parts of Japanese ampelopsis root, 12-18 parts of weeping forsythia, 5-15 parts of Momordica grossedentata, 15-30 parts of Chinese clematis root, 10-25 parts of Chinese pulsatilla root, 7-15 parts of Chinese honeylocust fruit, 7-15 parts of garden balsam stem, 15-30 parts of campsis grandiflora, 10-22 parts of safflower, 10-22 parts of cassia bark, 7-18 parts of white mustard seed, 7-18 parts of caulis sinomenii, 10-25 parts of black snake, 5-10 parts of centipede, 5-10 parts of camphor, 8-18 parts of myrrh, 20-25 parts of folium bubali, 10-20 parts of frankincense and 10-20 parts of Chinese thorn.
3. The external plaster according to claim 2, characterized by comprising the following raw materials: 30 parts of prepared common monkshood mother root, 22 parts of szechuan lovage rhizome, 12 parts of rhubarb, 18 parts of Ningpo yam rhizome, 30 parts of erythrina bark, 25 parts of Chinese angelica, 12 parts of red paeony root, 10 parts of dahurian angelica root, 10 parts of Japanese ampelopsis root, 15 parts of weeping forsythiae capsule, 12 parts of Momordica grosvenori, 25 parts of Chinese clematis, 17 parts of Chinese pulsatilla root, 9 parts of Chinese honeylocust fruit, 10 parts of garden balsam stem, 30 parts of campsis flower, 20 parts of safflower, 15 parts of cassia bark, 10 parts of white mustard seed, 10 parts of caulis sinomenii, 14 parts of black snake, 8 parts of centipede, 6 parts of camphor, 13 parts of myrrh, 22 parts of cloth residue leaf, 15 parts of frankincense and 15 parts of golden larch.
4. A method for preparing the topical Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of:
s1, weighing prepared common monkshood mother root, szechuan lovage rhizome, rhubarb, ningpo Yam rhizome, erythrina bark, chinese angelica, red paeony root, chinese honeylocust fruit, cassia bark and golden larch herb according to parts by weight, crushing the Chinese medicinal materials into powder by using a crusher, and sieving the powder by a 100-mesh sieve to obtain medicinal powder for later use;
s2, adding 80% ethanol solution with the weight 5-12 times of that of the traditional Chinese medicine powder obtained in the step S1 into the traditional Chinese medicine powder, performing ultrasonic extraction on the traditional Chinese medicine powder for 1-6 h, and filtering to obtain filtrate and filter residues for later use;
s3, weighing radix angelicae, radix ampelopsis, fructus forsythiae, semen momordicae, radix clematidis, pulsatilla chinensis, garden balsam stem, campsis grandiflora, safflower, semen brassicae, caulis sinomenii, zaocys dhumnades, centipede, camphor, myrrh, leaves of cloth residue and frankincense according to weight fraction, crushing into coarse powder, adding 85% ethanol solution with the weight 2-3 times of the coarse powder for soaking 1-3 h, fully expanding the coarse powder of the medicinal materials, uniformly filling the coarse powder into a percolator with absorbent cotton at the bottom for 2-3 times, filling the percolator with the filter residue obtained in the step S2 for 1-2 times, compacting by wood sticks after filling each time, slowly adding 85% ethanol solution from the upper part of the percolator, percolating and extracting 2-6 h, and collecting percolate for standby;
s4, combining the filtrate obtained in the step S2 and the percolate obtained in the step S3, heating and concentrating to 40-60% of the original volume, filtering, and cooling to room temperature to obtain concentrated liquid medicine;
s5, sub-packaging the concentrated liquid medicine obtained in the step S4 into a glass medicinal liquor bottle of 100 ml, and performing ultraviolet sterilization to obtain the external traditional Chinese medicine composition.
5. The method of claim 4, wherein the ethanol solution is used in the step S2 in an amount of 8 times and the extraction time is 3.5. 3.5 h.
6. The method of claim 4, wherein the percolation time in step S3 is 4h, and the concentration volume in step S4 is 50% of the original volume.
7. Use of a topical Chinese medicinal composition according to any one of claims 1-6 for the preparation of a medicament for the treatment of synovitis, tenosynovitis.
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