CN116878966B - Mass spectrum microsampling device - Google Patents
Mass spectrum microsampling device Download PDFInfo
- Publication number
- CN116878966B CN116878966B CN202311148956.1A CN202311148956A CN116878966B CN 116878966 B CN116878966 B CN 116878966B CN 202311148956 A CN202311148956 A CN 202311148956A CN 116878966 B CN116878966 B CN 116878966B
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- Prior art keywords
- pipe
- liquid
- circulating
- communicated
- air pressure
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- 238000001819 mass spectrum Methods 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 167
- 238000001514 detection method Methods 0.000 claims abstract description 7
- 238000007599 discharging Methods 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 31
- 238000010992 reflux Methods 0.000 claims description 16
- 238000005086 pumping Methods 0.000 claims description 8
- 238000004949 mass spectrometry Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 230000002209 hydrophobic effect Effects 0.000 description 6
- 238000005070 sampling Methods 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004853 microextraction Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
Abstract
The invention discloses a mass spectrum microsampling device, which belongs to the technical field of liquid taking detection equipment and comprises the following components: one end of the liquid taking pipe mechanism can extend into the vessel for liquid taking and conveying; the circulating liquid supply pipe is communicated with the liquid taking pipe mechanism and is used for circulating the sample liquid in the liquid taking pipe mechanism; the liquid taking component is vertically arranged at one side of the circulating liquid supply pipe; the liquid collecting component is connected with the circulating liquid supply pipe, and the liquid collecting component is connected with the circulating liquid supply pipe; according to the invention, the liquid taking pipe mechanism is matched with the circulating liquid supply pipe to promote the circulating circulation of the sample liquid, and the micro liquid extracting device is used for carrying out micro liquid discharging on the sample liquid in the flowing process, so that the micro liquid taking effect is realized.
Description
Technical Field
The invention belongs to the technical field of liquid sampling detection equipment, and particularly relates to a mass spectrum microsampling device.
Background
Mass spectrometers (Mass Spectrometer) are widely used to measure the mass of compounds and their molecular structure and composition, and provide detailed information about a sample by converting molecules in the compounds into ions and separating, detecting and analyzing the ions; at present, a mass spectrometer adopts a mass spectrum microsampling device to introduce a sample into the mass spectrometer for analysis before checking the sample, liquid taking and sucking are carried out through a pumping pipe in the prior art, the capacity and the volume are relatively large, and the microsampling effect is difficult to achieve.
Therefore, there is a need for a mass spectrometry microsampling device to solve the above-mentioned problems.
Disclosure of Invention
In order to achieve the above purpose, the present invention provides the following technical solutions: a mass spectrometry microsampling device, comprising:
one end of the liquid taking pipe mechanism can extend into the vessel for liquid taking and conveying;
the circulating liquid supply pipe is communicated with the liquid taking pipe mechanism and is used for circulating the sample liquid in the liquid taking pipe mechanism;
the liquid taking component is vertically arranged at one side of the circulating liquid supply pipe; and the drainage and transportation pipe is connected to one end, far away from the circulating liquid supply pipe, of the liquid taking component, and one end of the drainage and transportation pipe is communicated with the liquid supply pipe of the detection area of the mass spectrometer.
Further, preferably, the liquid taking tube mechanism includes:
a main tube;
the liquid taking pipe is coaxially fixed below the main pipe barrel and is communicated with the main pipe barrel;
the reflux head is sleeved outside the liquid taking pipe and fixed below the main pipe, one end of the circulating liquid supply pipe is communicated with the main pipe, and the other end of the circulating liquid supply pipe is communicated with the reflux head;
the fine-tuning pump is arranged on the circulating liquid supply pipe in series, the reflux head is internally provided with a double-layer structure, the circulating liquid supply pipe is connected with the inner cavity of the reflux head, and the inner cavity wall of the reflux head is provided with a plurality of flow holes.
Further, preferably, the liquid taking assembly includes:
the cross section of the transfer sleeve is in a cross-shaped structure, and the transfer sleeve is hermetically sleeved on the circulating liquid supply pipe;
the side pipe is transversely sealed and penetrated into the adapter sleeve, and a liquid hole is formed in the side wall of the side pipe;
the sealing tube is coaxially fixed at one end of the side tube; and the micro liquid pumping device is communicated with one side of the sealing tube.
Further, preferably, the liquid holes on the side pipes are uniformly and symmetrically distributed, and each liquid hole is provided with a hydrophobic net and a flow blocking net.
Further, preferably, the micro-fluid pumping device includes:
one side of the connecting pipe is fixed with the sealing pipe, and the other side of the connecting pipe is coaxially fixed with a shaft tube seat;
the sealing disc is coaxially arranged between the connecting pipe and the sealing pipe, and a plurality of side discharge channels are uniformly distributed on the sealing disc;
the liquid guide needle is arranged in each side drainage channel in a sliding way, a liquid bin is embedded and fixed in the connecting pipe, and the liquid bin is communicated with each side drainage channel on the sealing disc;
the guide pipe is coaxially fixed in the shaft tube seat, one end of the guide pipe is communicated with the liquid bin, and the other end of the guide pipe is connected with the discharge and conveying pipe;
the diameter adjusting disc is coaxially arranged in the connecting pipe in a sliding way and is in sliding connection with the guide pipe.
Further, preferably, an air pressure ring bin is coaxially arranged in the shaft tube seat, a piston head is slidably arranged in the air pressure ring bin, a push tube is sleeved outside the guide tube in a sliding manner, one end of the push tube is fixed with the piston head, the other end of the push tube is connected with the diameter-adjusting disc, an inner spring is arranged between the push tube and the shaft tube seat, and an air flow hole is arranged on the air pressure ring bin.
Further, preferably, the air flow hole is connected with an air pressure pipe in a sealing way, and the air pressure pipe intermittently or continuously conveys high-pressure air flow.
Further, preferably, the diameter-adjusting disc includes:
the positioning disc is coaxially and rotatably provided with a steering wheel on one side;
the positioning frames are circumferentially distributed on the positioning disc and are in sliding connection with the positioning disc, shaft pins are vertically fixed on the positioning frames, a plurality of inclined holes are correspondingly formed in the steering disc, and each shaft pin is arranged in each inclined hole in a sliding mode; and the contact plate frames are fixed on the positioning frames, and one ends of the contact plate frames are contacted with the liquid guide needles.
Further, preferably, a bullet opening groove is formed in the side discharging channel, a hemispherical groove is formed in the circumferential side wall of the bullet opening groove, and a sealing ring is further sleeved on the liquid guide needle.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the liquid taking pipe mechanism is matched with the circulating liquid supply pipe to promote the circulating circulation of the sample liquid, and the micro liquid extracting device is used for carrying out micro liquid discharging on the sample liquid in the flowing process, so that the micro liquid taking effect is realized.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of a liquid-taking tube mechanism according to the present invention;
FIG. 3 is a schematic view of a liquid-extracting component according to the present invention;
FIG. 4 is a schematic view of the side tube structure of the present invention;
FIG. 5 is a schematic diagram of a micropump device according to the present invention;
FIG. 6 is a schematic view of the diameter-adjusting disc according to the present invention;
FIG. 7 is a schematic view of the structure of the sealing disk of the present invention;
FIG. 8 is a schematic view of the structure of the liquid guiding needle in the present invention;
in the figure: 1. a liquid taking pipe mechanism; 11. a main tube; 12. a reflow head; 13. a liquid taking tube; 2. a circulating liquid supply pipe; 21. a discharge pipe; 22. a fine tuning pump; 3. a liquid taking component; 31. a transfer sleeve; 32. a side pipe; 33. sealing the tube; 34. a sparse net; 35. a flow blocking net; 4. a micro-liquid pumping device; 41. a connecting pipe; 42. a shaft tube seat; 43. a sealing plate; 44. a liquid bin; 45. a liquid guide needle; 46. a guide pipe; 47. pushing the bobbin; 48. a pneumatic ring bin; 49. a piston head; 5. a diameter-adjusting disc; 51. a positioning plate; 52. a steering wheel; 53. a positioning frame; 54. inclined holes; 6. and (3) a sealing ring.
Detailed Description
Referring to fig. 1 to 8, in an embodiment of the present invention, a mass spectrometry microsampling device includes:
one end of the liquid taking pipe mechanism 1 can extend into the vessel for liquid taking and conveying;
the circulating liquid supply pipe 2 is communicated with the liquid taking pipe mechanism 1 and is used for circulating the sample liquid in the liquid taking pipe mechanism 1;
the liquid taking component 3 is vertically arranged at one side of the circulating liquid supply pipe 2; and a drainage tube 21 connected to the liquid sampling assembly 3 at an end far away from the circulating liquid supply tube 2, wherein one end of the drainage tube 21 is communicated with a liquid supply tube (not shown) in a detection area of the mass spectrometer, that is, the liquid sampling assembly 3 can pump the sample liquid when circulating, so as to realize a micro sampling effect.
In this embodiment, the liquid taking tube mechanism 1 includes:
a main tube 11;
the liquid taking pipe 13 is coaxially fixed below the main pipe barrel 11 and is communicated with the main pipe barrel 11;
the reflux head 12 is sleeved outside the liquid taking pipe 13 and fixed below the main pipe 11, one end of the circulating liquid supply pipe 2 is communicated with the main pipe 11, and the other end of the circulating liquid supply pipe is communicated with the reflux head 12;
the micro-adjusting pump 22 is serially connected to the circulating liquid supply pipe 2, the inside of the reflux head 12 is in a double-layer structure, the circulating liquid supply pipe 2 is connected with the inner cavity of the reflux head 12, and a plurality of flow holes are formed in the inner cavity wall of the reflux head 12, that is, the micro-adjusting pump 22 can provide negative pressure extraction for the main pipe barrel 11, and the sample liquid is circularly conveyed to the inner cavity of the reflux head 12 through the circulating liquid supply pipe 2 after entering the main pipe barrel 11 and flows out through the flow holes to enter the vessel again, so that the sample liquid circulation is formed.
As a preferred embodiment, the liquid taking assembly 3 includes:
the cross section of the switching sleeve 31 is in a cross-shaped structure, and the switching sleeve 31 is hermetically sleeved on the circulating liquid supply pipe 2;
a side pipe 32 is transversely sealed and penetrated in the adapter sleeve 31, and a liquid hole is formed in the side wall of the side pipe 32;
a seal tube 33 coaxially fixed to one end of the side tube 32; and the micro liquid pumping device 4 is communicated with one side of the sealing tube 33 away from the side tube 32, and when the sample liquid passes through the liquid hole, the sample liquid is discharged to the sealing tube 33 through the side tube 32 and then is discharged by the circulating liquid supply tube 2.
In this embodiment, the liquid holes on the side pipes 32 are uniformly and symmetrically distributed, and a hydrophobic net 34 and a choke net 35 are respectively disposed in each liquid hole, where the hydrophobic net 34 is a common filtering mesh, the choke net 35 is a permeable mesh, and the same hydrophobic net or choke net can be distributed in the symmetrically disposed liquid holes, or one of the hydrophobic nets and the other of the hydrophobic nets can be distributed to adjust the flow rate of the sample liquid flowing through the side pipes 32.
In this embodiment, the micro-fluid pumping device 4 includes:
a connecting pipe 41, one side of which is fixed to the sealing pipe 33, and the other side of which is coaxially fixed to a shaft holder 42;
a sealing disc 43 coaxially arranged between the connecting pipe 41 and the sealing pipe 33, wherein a plurality of side discharge channels are uniformly distributed on the sealing disc 43;
a liquid guide needle 45 slidably disposed in each side drain, wherein a liquid bin 44 is fixedly embedded in the connecting pipe 41, and the liquid bin 44 is communicated with each side drain on the sealing disk 43;
a guide pipe 46 coaxially fixed in the shaft tube holder 42, one end of the guide pipe 46 being connected to the liquid tank 44, and the other end being connected to the discharge pipe 21;
the diameter-adjusting disc 5 is coaxially and slidably arranged in the connecting pipe 41, and the diameter-adjusting disc 5 is slidably connected with the guide pipe 46, wherein the diameter-adjusting disc 5 can always contact with the end part of the liquid guide needle 45, and the liquid guide needle 45 can be retracted into the side drainage channel under the action of a spring.
In this embodiment, the shaft tube seat 42 is coaxially provided with a pneumatic ring chamber 48, a piston head 49 is slidably disposed in the pneumatic ring chamber 48, a push tube 47 is slidably sleeved outside the guide tube 46, one end of the push tube 47 is fixed to the piston head 49, the other end of the push tube is connected to the diameter-adjusting disc 5, an inner spring is disposed between the push tube 47 and the shaft tube seat 42, and an air flow hole is disposed on the pneumatic ring chamber 48.
As a preferred embodiment, the air flow hole is hermetically connected with an air pressure pipe, and the air pressure pipe intermittently or continuously conveys high-pressure air flow, so that the push tube 47 can axially slide reciprocally, so as to push the liquid guide needle 45 and the side drainage channel to form a liquid discharge gap in liquid taking, and thus micro liquid taking is performed.
In this embodiment, the diameter-adjusting disc 5 includes:
a positioning plate 51, one side of which is coaxially and rotatably provided with a steering plate 52;
the positioning frame 53 is circumferentially distributed on the positioning disc 51 and is in sliding connection with the positioning disc 51, a shaft pin is vertically fixed on the positioning frame 53, a plurality of inclined holes 54 are correspondingly formed in the steering disc 52, and each shaft pin is slidably arranged in each inclined hole 54; and a contact plate frame fixed on each positioning frame 53, wherein one end of the contact plate frame is contacted with the liquid guide needles 45, the contact plate frame can be contacted with the liquid guide needles 45 correspondingly distributed under radial adjustment, and when the contact plate frame is far away from the axis for adjustment, the contact plate frame is contacted with the liquid guide needles 45 in a smaller quantity, and at the moment, the diameter-adjusting disc 5 can form micro extraction of the flowing sample liquid under the instantaneous pushing of the push tube 47.
In this embodiment, a bullet slot is disposed in the side drainage channel, the liquid guide needle 45 extends into a hemispherical slot disposed on a circumferential side wall of the bullet slot, and the liquid guide needle 45 is further sleeved with a sealing ring 6, that is, when the liquid guide needle 45 has no external force, the sample liquid can flow into the hemispherical slot, the sealing ring 6 forms a sealing plug of the side drainage channel, and when the liquid guide needle is pushed to slide out relatively, the liquid guide needle 45 and the side drainage channel form a liquid discharge gap at this time, and the sample liquid in the hemispherical slot can flow into the side drainage channel, thereby entering the liquid bin 44.
Specifically, the liquid taking pipe mechanism 1 works to realize circulating circulation of the sample liquid through the circulating liquid supply pipe 2, the liquid guide needle 45 in the liquid taking assembly 3 can relatively slide out of the side discharge channel in the circulating process under the contact of the diameter adjusting disc 5, the sample liquid flows through the liquid discharge gap, and the sample liquid flows to the liquid guide pipe 46 through the liquid bin 44 at the moment, so that the sample liquid is discharged from the discharge pipe 21 to the liquid supply pipe of the detection area of the mass spectrometer for detection.
The foregoing description is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical solution of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (4)
1. A mass spectrometry microsampling device, comprising:
one end of the liquid taking pipe mechanism (1) can extend into the vessel for liquid taking and conveying;
the circulating liquid supply pipe (2) is communicated with the liquid taking pipe mechanism (1) and is used for circulating the sample liquid in the liquid taking pipe mechanism (1);
the liquid taking component (3) is vertically arranged at one side of the circulating liquid supply pipe (2); and a discharge pipe (21) connected to the liquid taking assembly (3) at one end far away from the circulating liquid supply pipe (2), wherein one end of the discharge pipe (21) is communicated with the liquid supply pipe of the detection area of the mass spectrometer;
the liquid taking pipe mechanism (1) comprises:
a main tube (11);
the liquid taking pipe (13) is coaxially fixed below the main pipe barrel (11) and is communicated with the main pipe barrel (11);
the reflux head (12) is sleeved outside the liquid taking pipe (13) and fixed below the main pipe (11), one end of the circulating liquid supply pipe (2) is communicated with the main pipe (11), and the other end of the circulating liquid supply pipe is communicated with the reflux head (12);
the fine-tuning pump (22) is arranged on the circulating liquid supply pipe (2) in series, the reflux head (12) is internally provided with a double-layer structure, the circulating liquid supply pipe (2) is connected with the inner cavity of the reflux head (12), and the inner cavity wall of the reflux head (12) is provided with a plurality of flow holes;
the liquid taking component (3) comprises:
the cross section of the switching sleeve (31) is in a cross-shaped structure, and the switching sleeve (31) is hermetically sleeved on the circulating liquid supply pipe (2);
the side pipe (32) is transversely sealed and penetrated into the adapter sleeve (31), and a liquid hole is formed in the side wall of the side pipe (32);
a seal pipe (33) coaxially fixed to one end of the side pipe (32); and a micro liquid pumping device (4) communicated with one side of the sealing tube (33) far away from the side tube (32);
the liquid holes on the side pipes (32) are uniformly and symmetrically distributed, and a sparse net (34) and a choked flow net (35) are respectively arranged in each liquid hole;
the micro-fluid pumping device (4) comprises:
a connecting pipe (41), one side of which is fixed with the sealing pipe (33), and the other side of which is coaxially fixed with a shaft tube seat (42);
the sealing disc (43) is coaxially arranged between the connecting pipe (41) and the sealing pipe (33), and a plurality of side discharge channels are uniformly distributed on the sealing disc (43);
the liquid guide needle (45) is arranged in each side drainage channel in a sliding manner, a liquid bin (44) is embedded and fixed in the connecting pipe (41), and the liquid bin (44) is communicated with each side drainage channel on the sealing disc (43);
a guide pipe (46) coaxially fixed in the shaft tube seat (42), one end of the guide pipe (46) is communicated with the liquid bin (44), and the other end of the guide pipe is connected with the discharge and conveying pipe (21);
the diameter-adjusting disc (5) is coaxially and slidably arranged in the connecting pipe (41), and the diameter-adjusting disc (5) is slidably connected with the guide pipe (46);
the novel air pressure type air pressure pipe comprises an air pressure pipe seat (42), and is characterized in that an air pressure pipe seat (48) is coaxially arranged in the air pressure pipe seat (42), a piston head (49) is arranged in the air pressure pipe seat (48) in a sliding mode, a push pipe (47) is sleeved outside the guide pipe (46) in a sliding mode, one end of the push pipe (47) is fixed with the piston head (49), the other end of the push pipe is connected with a diameter adjusting disc (5), an inner spring is arranged between the push pipe (47) and the air pressure pipe seat (42), and an air flow hole is formed in the air pressure pipe seat (48).
2. A mass spectrometry microsampling device according to claim 1, wherein: the air flow hole is connected with an air pressure pipe in a sealing way, and the air pressure pipe intermittently or continuously conveys and discharges high-pressure air flow.
3. A mass spectrometry microsampling device according to claim 1, wherein: the diameter-adjusting disc (5) comprises:
a positioning disk (51) with a steering wheel (52) coaxially and rotatably arranged on one side;
the positioning frames (53) are circumferentially distributed on the positioning disc (51) and are in sliding connection with the positioning disc (51), shaft pins are vertically fixed on the positioning frames (53), a plurality of inclined holes (54) are correspondingly formed in the steering disc (52), and each shaft pin is arranged in the inclined hole (54) in a sliding mode; and the contact plate frames are fixed on the positioning frames (53), and one ends of the contact plate frames are contacted with the liquid guide needles (45).
4. A mass spectrometry microsampling device according to claim 1, wherein: the side discharging channel is internally provided with a warhead opening groove, a hemispherical groove is formed in the circumferential side wall of the warhead opening groove, and the liquid guide needle (45) is sleeved with a sealing ring (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311148956.1A CN116878966B (en) | 2023-09-07 | 2023-09-07 | Mass spectrum microsampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311148956.1A CN116878966B (en) | 2023-09-07 | 2023-09-07 | Mass spectrum microsampling device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116878966A CN116878966A (en) | 2023-10-13 |
| CN116878966B true CN116878966B (en) | 2023-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN202311148956.1A Active CN116878966B (en) | 2023-09-07 | 2023-09-07 | Mass spectrum microsampling device |
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| CN116878966A (en) | 2023-10-13 |
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