CN116870070A - Traditional Chinese medicine composition for treating acne and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating acne and preparation method thereof Download PDFInfo
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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Abstract
The invention relates to the technical field of traditional Chinese medicine formulas, and discloses a traditional Chinese medicine composition for treating acne and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: 6 to 12 parts of angelica, 3 to 9 parts of szechuan lovage rhizome, 6 to 12 parts of raw white paeony root, 6 to 12 parts of prepared rehmannia root, 0.4 to 1.5 parts of salt and 0 to 10 parts of skin conditioning agent. The preparation method specifically comprises the following steps: s1, crushing the rest raw materials except for the prepared rehmannia root, adding water for refluxing, and filtering to obtain filtrate I and filter residue I; s2, adding the filter residue I obtained by the prepared rehmannia root and the S1 into the filtrate I prepared by the S1, adding ethanol for reflux extraction, filtering, and removing the solvent to obtain the traditional Chinese medicine composition. The Chinese angelica, the raw white paeony root, the prepared rhizome of rehmannia, the szechuan lovage rhizome and the salt are compatible, and the monarch, minister, assistant and guide functions and the synergistic effect enable the Chinese angelica to activate blood and remove blood stasis in a yang-warming mode, so that the traditional acne is treated, and the possibility of recurrence is radically eliminated.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating acne and a preparation method thereof.
Background
Acne is a chronic skin disease, is common skin disease of teenagers and young adults, is well developed at the position of rich sebaceous glands such as face, chest, back and the like, forms pimples, acnes, pustules, nodules or cysts and other lesions, is mostly developed for young men and women aged 15-30 years, and skin lesions are well developed at cheeks, forehead, chest back and shoulders. If the acne is not treated timely or thoroughly, the appearance of the patient is greatly damaged, and psychological anxiety is generated for the patient.
At present, for the treatment of acne, western medicine mainly uses antiandrogens, antibiotics, tretinoin, benzoyl peroxide and the like and topical medicines, and long-term administration can cause stimulation symptoms such as hormone level disorder, antibiotic resistance, skin redness, stinging, erythema and the like, and has poor curative effect and easy recurrence. Traditional Chinese medicine holds that: acne is usually caused by wind-heat resistance of lung channel on skin, or by overfeeding of fat, sweet, greasy and spicy food, spleen and stomach heat accumulation, damp-heat generation and fumigation on face; or the ascending of yang-heat due to the youth body, the rigid blood-qi, and the ascending of yang-heat. Therefore, in the prior art, the traditional Chinese medicine is used for treating acne, is influenced by the traditional thinking, and is considered that the acne is not separated from damp-heat, and the treatment is carried out by using heat-clearing and detoxifying medicines of a large team, and refers to Chinese patent CN108159145B. The patent discloses a traditional Chinese medicine composition for treating acne, which is prepared from the following raw materials in parts by weight: 33 parts of loquat leaf, 22 parts of baical skullcap root, 67 parts of dandelion, 22 parts of weeping forsythiae capsule, 33 parts of mongolian snakegourd root, 22 parts of spina gleditsiae, 44 parts of red sage root, 33 parts of eclipta, 33 parts of glossy privet fruit and 13 parts of liquoric root. In the patent, a large amount of cold and cool medicines are used to remove the heat toxin accumulated in the body of a patient. Healthy people can normally distribute yang heat in the body through skin striae by self, but the pathogenic factors of the patients are various, and the yang heat cannot normally distribute yang heat by self due to stagnation of heat toxin in the body, or cold from body surface, or loss of joints due to diet, cold coagulation and stasis or excessive yang of physique. A large amount of cold and cool drugs can only temporarily clear heat evil in a patient, cold nature is induced, nutrient and blood stasis is achieved, stasis and toxin are removed, collaterals are hidden, diet is calm, and the heat is removed due to long-term depression, so that acne recurs again, cycles and is difficult to heal.
Disclosure of Invention
The invention discloses a traditional Chinese medicine composition for treating acne and a preparation method thereof, and solves the problems that in the prior art, when the acne is treated, a large amount of cold and cool medicines are used, heat evil in a patient can only be temporarily cleared, but stasis and toxin are difficult to eliminate, and collaterals are hidden, so that the acne is easy to relapse and the disease is repeated.
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 6 to 12 parts of angelica, 3 to 9 parts of szechuan lovage rhizome, 6 to 12 parts of raw white paeony root, 6 to 12 parts of prepared rehmannia root, 0.4 to 1.5 parts of salt and 0 to 10 parts of skin conditioning agent.
Preferably, the Chinese medicinal composition comprises: 8 to 10 parts of angelica, 5 to 7 parts of szechuan lovage rhizome, 8 to 10 parts of raw white paeony root, 8 to 10 parts of prepared rehmannia root, 0.8 to 1.1 parts of salt and 0 to 10 parts of skin conditioning agent.
Preferably, the Chinese medicinal composition comprises: 6 parts of Chinese angelica, 3 parts of szechuan lovage rhizome, 6 parts of raw white paeony root, 6 parts of prepared rehmannia root and 0.4 part of salt.
Preferably, the Chinese medicinal composition comprises: 9 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 9 parts of raw white paeony root, 9 parts of prepared rehmannia root and 1 part of salt.
Preferably, the Chinese medicinal composition comprises: 12 parts of Chinese angelica, 9 parts of szechuan lovage rhizome, 12 parts of raw white paeony root, 12 parts of prepared rehmannia root and 1.5 parts of salt.
The second aim of the invention is to protect a preparation method of a traditional Chinese medicine composition for treating acne, which specifically comprises the following steps:
s1, crushing the rest raw materials except for the prepared rehmannia root, adding water for refluxing, and filtering to obtain filtrate I and filter residue I;
s2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol for reflux extraction, filtering, and removing the solvent from the filtrate to obtain the traditional Chinese medicine composition.
Preferably, the residual raw material in S1 is water=1g:7mL.
Preferably, the reflux conditions of the water in the step S1 are as follows: reflux is carried out for 3-4 h at 90-100 ℃.
Preferably, in S2, radix rehmanniae Preparata (residue I+filtrate I) ethanol=1g:1g:10mL.
Preferably, the reflux conditions of the added ethanol in S2 are as follows: reflux is carried out for 2-3 h at 70-75 ℃.
The efficacy and effect of the traditional Chinese medicine composition are as follows:
the invention considers that healthy people can release the internal yang heat through the normal opening and closing of skin striae, and acne is caused by cold evil, striae disregulation, cold coagulation and stasis and heat Yu Yu, or excessive heat of physique, food consumption and loss of node, internal fire toxin generation, toxicity accumulation, and heat toxin burning of nutrient and blood, thus causing nutrient and blood stasis. The heat dissipation channels of skin striae are not smooth, so that yang heat in the body cannot be dissipated, and the yang heat is decocted for a long time to burn the nutrient blood, stagnate in the body and transform fire toxin into pimples, acnes, pustules, nodules or cysts, namely acnes. Acne is caused by stagnation of nutrient-blood and obstruction of yang-heat, and fire toxin is generated internally. Therefore, the most important treatment of acne is to use general formula, to use a method of activating yang and dispelling fire, to use a medicament for warming yang and activating blood circulation to dissipate blood stasis of cold accumulation or heat toxin, to open a heat dissipation channel of stasis, and to naturally dissipate the accumulated yang heat from skin striae, so as to radically treat acne, and to avoid the possibility of later recurrence.
Chinese angelica root: sweet, pungent and warm. It enters liver, heart and spleen meridians. Has effects of replenishing blood, promoting blood circulation, and removing blood stasis. Dang Gui can tonify and moisten, pungent and warm in nature, and dispel the flow of qi, enter liver and heart meridians and spleen meridians. It is good at replenishing blood and activating blood, regulating menstruation and relieving pain, relaxing bowel, and dispelling cold, so it is indicated for deficiency of blood and cold due to blood stasis.
Ligusticum wallichii: pungent and warm in property. Enter liver, gallbladder and pericardium meridians. Rhizoma Ligustici Chuanxiong Xin Xianghang is used for dispelling heat and dredging, and is added into liver, gallbladder and pericardium channels. Ascending head and descending blood sea, moving blood and qi internally and dispelling wind-cold externally. Has strong blood circulation promoting effect and can be used for treating blood stasis and qi.
Raw white peony root: bitter and sour properties and slightly cold. Enter liver and spleen meridians. Has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang.
Prepared rehmannia root: sweet in property and slightly warm. It enters liver and kidney meridians. Has effects of replenishing blood, nourishing yin, replenishing vital essence, and replenishing marrow. The prepared rehmannia root is used for treating blood deficiency, wilt, palpitation, irregular menstruation, metrorrhagia, bleeding, deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to steaming bone, night sweat, spermatorrhea, internal heat, diabetes, dizziness, tinnitus and premature graying of hair.
Salt: salty in property, slightly pungent in property, cold in nature, clear fire, cool blood and detoxify.
Compared with the prior art, the invention has the beneficial effects that:
the invention takes prepared rhizome of rehmannia, chinese angelica and raw white peony root as monarch drugs and Ligusticum wallichii as ministerial drugs. Prepared rehmannia root, radix rehmanniae Preparata is warm and moist in nature and is effective in replenishing blood, promoting blood circulation, nourishing yin, wen Runzi greasy to treat pungent and dry nature of Chuan Xiong, so as to prevent pungent and dry nature from damaging fluids and skin. The angelica has the effects of enriching blood and dispelling cold while activating blood and dissolving stasis; sheng Bai Shao is slightly cold in nature, white in color belongs to gold, and has the actions of clearing wind-heat in lung meridian, cooling blood, activating blood and whitening skin. The ligusticum chuanxiong is taken as a ministerial drug, xin Xianghang dissipates heat and communicates, qi is moved to activate blood, the ligusticum chuanxiong has the functions of ascending the head and face, warming yang to dispel cold, pungent and dry can remove excessive grease, regulate skin grease secretion and prevent mite breeding. The salt is used as an adjuvant drug for cooling blood and detoxifying. According to the invention, angelica sinensis, radix paeoniae alba, prepared rhizome of rehmannia, ligusticum wallichii and salt are compatible, blood circulation is promoted and yang is removed by a warm-dredging and blood-activating method, yang Rebu is dispersed, fire toxin is biochemically reduced in source, and the bottom of the stillage is drawn to prevent toxin stasis and accumulation, and long-time recurrence is prevented, and the monarch, minister, assistant and guide effects and synergistic effects are achieved, so that the traditional acne is treated by the stagnation and yang heat dredged by the warm-dredging and-activating method, and the possibility of recurrence is radically stopped.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described in the following in conjunction with the specific embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 6g of angelica, 3g of ligusticum wallichii, 6g of raw white peony root, 6g of prepared rehmannia root and 0.4g of salt.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 80 meshes, adding water, refluxing at 90 ℃ for 3 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 2 hours at 70 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to the affected part for 10min for 1 time/day.
Example 2
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 8g of angelica, 5g of ligusticum wallichii, 8g of raw white peony root, 8g of prepared rehmannia root and 0.8g of salt.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 80 meshes, adding water, refluxing at 95 ℃ for 3.5 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 2.5 hours at 70 ℃, filtering, and removing the ethanol from the filtrate by rotary evaporation to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 15min for 1 time/day.
Example 3
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 9g of angelica, 6g of ligusticum wallichii, 9g of raw white peony root, 9g of prepared rehmannia root and 1g of salt.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 20min for 1 time/day.
Example 4
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 12g of Chinese angelica, 9g of szechuan lovage rhizome, 12g of raw white paeony root, 12g of prepared rehmannia root and 1.5g of salt.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 25min for 1 time/day.
Example 5
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 10g of angelica sinensis, 7g of ligusticum wallichii, 10g of raw white paeony root, 10g of prepared rhizome of rehmannia, 1.1g of salt and 10g of skin conditioner;
when the patient is scar constitution, the skin regulator is semen Persicae.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 25min for 1 time/day.
Example 6
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 12g of angelica sinensis, 9g of ligusticum wallichii, 12g of raw white paeony root, 12g of prepared rehmannia root, 1.5g of salt and 10g of skin conditioner;
when the patient is dry skin, the skin conditioner is Atractylodis rhizoma.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 25min for 1 time/day.
Example 7
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 12g of angelica sinensis, 9g of ligusticum wallichii, 12g of raw white paeony root, 12g of prepared rehmannia root, 1.5g of salt and 3g of skin conditioner;
when the patient is oily skin, the skin regulator is rhizoma Ligustici Chuanxiong.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 25min for 1 time/day.
Example 8
A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 12g of angelica sinensis, 9g of ligusticum wallichii, 12g of raw white paeony root, 12g of prepared rehmannia root, 1.5g of salt and 3g of skin conditioner;
the skin conditioner is white peony root when the patient needs to whiten.
A preparation method of a traditional Chinese medicine composition for treating acne specifically comprises the following steps:
s1, crushing the rest raw materials except the prepared rehmannia root according to the formula amount to 100 meshes, adding water, refluxing at 100 ℃ for 4 hours, filtering to obtain filter residue I and filtrate, and rotationally evaporating the filtrate to obtain filtrate I; wherein, the residual raw materials are water=1g:7ml.
S2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol, refluxing for 3 hours at 75 ℃, filtering, and removing the ethanol by rotary evaporation of the filtrate to obtain the traditional Chinese medicine composition; wherein, the prepared rhizome of rehmannia (filter residue I+filtrate I) is ethanol=1g:1g:10mL.
When the patient is in acute stage acne, selecting radix rehmanniae Preparata from the residue obtained by filtering in S2, pulverizing to 80 mesh, and applying to affected part for 25min for 1 time/day.
Comparative example 1
Refer to example 1 of chinese patent CN108159145B.
The traditional Chinese medicine composition for treating acne is prepared from the following raw materials in parts by weight: 33 parts of loquat leaf, 22 parts of baical skullcap root, 67 parts of dandelion, 22 parts of weeping forsythiae capsule, 33 parts of mongolian snakegourd root, 22 parts of spina gleditsiae, 44 parts of red sage root, 33 parts of eclipta, 33 parts of glossy privet fruit and 13 parts of liquoric root. Decocting the raw materials with water twice, adding 8 times of water for the first time, decocting for 1.5h, and filtering; adding 6 times of water for the second time, decocting for 1.5h, filtering, and mixing filtrates; concentrating under reduced pressure at below 65deg.C to obtain Chinese medicinal composition for treating acne.
Effect verification
1. Patient data
120 clinical cases were collected according to clinical manifestations of acne, inflammatory and papules, pustules, and node cysts. 60 men and 60 women are 15-18 years old.
2. Therapeutic method
Take the face as an example.
Patients were divided into 4 groups of 30 persons each, each group having 15 men and 15 women, each group being treated with the Chinese medicinal compositions of examples 1 to 3 and comparative example 1 of the present invention, respectively. The methods of use of examples 1-3 were: washing the affected part with 38-41 deg.c water, mixing the Chinese medicinal composition with 38-41 deg.c hot water for 2-3min, and air drying. During cleaning, the forehead, temple, front ear, back ear, chin, side of nose wing and other parts should be cleaned, and towel scrubbing is forbidden. The method has no special requirement in the morning and evening, and is suitable for washing the face at 9 to 10 points in the evening. Cold water is forbidden to wash the face during the administration period, and diet is forbidden to be spicy, so that sleeping for 7-8 hours per day is ensured as much as possible, 8 weeks are a treatment course, and the recurrence rate is 6 months after follow-up.
The method of use of comparative example 1 is: the traditional Chinese medicine composition of the comparative example 1 is coated on an affected part after the face is washed with water at 38-41 ℃ and naturally dried, the coating thickness is 1mm, the time is 20min, and then the traditional Chinese medicine composition is washed with water at 38-41 ℃. Each time in the morning and evening. Cold water is forbidden to wash the face during the administration period, and diet is forbidden to be spicy, so that sleeping for 7-8 hours per day is ensured as much as possible, 8 weeks are a treatment course, and the recurrence rate is 6 months after follow-up. The face is washed by water mixed with the liquid medicine at 38-41 ℃, the hands are washed, the forehead and the temple of the front ear and the back ear are washed, and the chin can not be scrubbed by a towel.
3. Standard of efficacy:
(1) And (3) healing: facial acne disappears or substantially disappears;
(2) The effect is shown: the facial acne is reduced by more than 75% compared with the facial acne before treatment;
(3) The method is effective: the facial acne is reduced by 25 to 75 percent compared with the acne before treatment;
(4) Invalidation: facial acne was reduced less than 25% earlier.
4. Comparison of therapeutic effects of different groups:
table 1 comparison of the efficacy of the different examples and comparative examples
As can be seen from Table 1, examples 1-8 have a total effective rate in treating acne that is much higher than that of comparative example 1, and in particular, the recurrence rate is much lower than that of comparative example 1. Probably because the raw material components used in the comparative example 1 are cold and cool medicines, although the heat in the patient is removed, the skin of the patient is blocked due to cold and is not dredged, after the heat is generated in the later period of the body, the patient still cannot dissipate the heat by the patient, and the generated heat still can be blocked in the body, so that acne recrudescence is caused. Meanwhile, the formulas of the scheme are modified according to different physique and requirements of patients in examples 5-8, so that the prescription is more targeted and the curative effect is better.
While the preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. A traditional Chinese medicine composition for treating acne, the traditional Chinese medicine composition comprising: 6 to 12 parts of angelica, 3 to 9 parts of szechuan lovage rhizome, 6 to 12 parts of raw white paeony root, 6 to 12 parts of prepared rehmannia root, 0.4 to 1.5 parts of salt and 0 to 10 parts of skin conditioning agent.
2. The traditional Chinese medicine composition for treating acne according to claim 1, wherein the traditional Chinese medicine composition comprises: 8 to 10 parts of angelica, 5 to 7 parts of szechuan lovage rhizome, 8 to 10 parts of raw white paeony root, 8 to 10 parts of prepared rehmannia root, 0.8 to 1.1 parts of salt and 0 to 10 parts of skin conditioning agent.
3. The traditional Chinese medicine composition for treating acne according to claim 1, wherein the traditional Chinese medicine composition comprises: 6 parts of Chinese angelica, 3 parts of szechuan lovage rhizome, 6 parts of raw white paeony root, 6 parts of prepared rehmannia root and 0.4 part of salt.
4. The traditional Chinese medicine composition for treating acne according to claim 1, wherein the traditional Chinese medicine composition comprises: 9 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 9 parts of raw white paeony root, 9 parts of prepared rehmannia root and 1 part of salt.
5. The traditional Chinese medicine composition for treating acne according to claim 1, wherein the traditional Chinese medicine composition comprises: 12 parts of Chinese angelica, 9 parts of szechuan lovage rhizome, 12 parts of raw white paeony root, 12 parts of prepared rehmannia root and 1.5 parts of salt.
6. The preparation method of the traditional Chinese medicine composition for treating acne according to claim 1, which is characterized by comprising the following steps:
s1, crushing the rest raw materials except for the prepared rehmannia root, adding water for refluxing, and filtering to obtain filtrate I and filter residue I;
s2, adding the filter residue I obtained by the prepared rehmannia root and the S1 in the formula amount into the filtrate I prepared by the S1, adding ethanol for reflux extraction, filtering, and removing the solvent from the filtrate to obtain the traditional Chinese medicine composition.
7. The method for preparing a traditional Chinese medicine composition for treating acne according to claim 4, wherein the residual raw materials in S1 are water=1g:7mL.
8. The method for preparing a traditional Chinese medicine composition for treating acne according to claim 5, wherein the reflux condition of water in the step S1 is as follows: reflux is carried out for 3-4 h at 90-100 ℃.
9. The method for preparing a Chinese medicinal composition for treating acne according to claim 4, wherein the prepared rehmannia root in S2 (filter residue I+filtrate I) ethanol=1g:1g:10mL.
10. The method for preparing a traditional Chinese medicine composition for treating acne according to claim 7, wherein the reflux condition of the added ethanol in the step S2 is as follows: reflux is carried out for 2-3 h at 70-75 ℃.
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Application publication date: 20231013 |