CN116869983A - 包含对乙酰氨基酚和磺烷基醚环糊精的制剂 - Google Patents
包含对乙酰氨基酚和磺烷基醚环糊精的制剂 Download PDFInfo
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- CN116869983A CN116869983A CN202310814285.1A CN202310814285A CN116869983A CN 116869983 A CN116869983 A CN 116869983A CN 202310814285 A CN202310814285 A CN 202310814285A CN 116869983 A CN116869983 A CN 116869983A
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- CN
- China
- Prior art keywords
- formulation
- acetaminophen
- sulfoalkyl ether
- ether cyclodextrin
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000009472 formulation Methods 0.000 title claims abstract description 194
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title claims abstract description 143
- 229960005489 paracetamol Drugs 0.000 title claims abstract description 101
- 229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 95
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims abstract description 93
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Applications Claiming Priority (4)
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|---|---|---|---|
| US201662395794P | 2016-09-16 | 2016-09-16 | |
| US62/395,794 | 2016-09-16 | ||
| CN201780071033.7A CN110167543A (zh) | 2016-09-16 | 2017-09-15 | 包含对乙酰氨基酚和磺烷基醚环糊精的制剂 |
| PCT/US2017/051919 WO2018053358A1 (en) | 2016-09-16 | 2017-09-15 | Formulations containing acetaminophen and sulfoalkyl ether cyclodextrin |
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| CN201780071033.7A Division CN110167543A (zh) | 2016-09-16 | 2017-09-15 | 包含对乙酰氨基酚和磺烷基醚环糊精的制剂 |
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| CN201780071033.7A Pending CN110167543A (zh) | 2016-09-16 | 2017-09-15 | 包含对乙酰氨基酚和磺烷基醚环糊精的制剂 |
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| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| WO2009098716A2 (en) * | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| ES2545484T3 (es) * | 2009-07-23 | 2015-09-11 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Formulación de paracetamol inyectable, estable, lista para usar |
| PH12013500477A1 (en) * | 2010-09-13 | 2018-01-17 | Bev Rx Inc | Aqueous drug delivery system comprising off-flavor masking agent |
| CN110066351B (zh) * | 2012-02-28 | 2022-06-14 | 锡德克斯药物公司 | 烷基化环糊精组合物及其制备和使用方法 |
| CN102871994B (zh) * | 2012-09-29 | 2015-07-29 | 中国科学院大连化学物理研究所 | 氟比洛芬对乙酰氨基酚酯环糊精包合物及其制备方法 |
| BR102014005885B1 (pt) * | 2014-03-13 | 2021-04-13 | Biotec Biológica Indústria Farmacêutica Ltda E.P.P | Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso |
| SI3411047T1 (sl) * | 2016-02-04 | 2021-09-30 | Czap Research And Development, Llc | Sredstva za nadzorovano sproščeni in stratificirani kompleks vključitve ciklodekstrina |
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| MX2023003761A (es) | 2023-04-26 |
| KR20240005122A (ko) | 2024-01-11 |
| AU2023203660A1 (en) | 2023-07-06 |
| JP2024051102A (ja) | 2024-04-10 |
| JP7181185B2 (ja) | 2022-11-30 |
| AU2017326519B2 (en) | 2023-03-16 |
| AU2025204233A1 (en) | 2025-06-26 |
| CA3036989A1 (en) | 2018-03-22 |
| US20190255000A1 (en) | 2019-08-22 |
| WO2018053358A1 (en) | 2018-03-22 |
| AU2017326519A1 (en) | 2019-04-11 |
| RU2019107764A (ru) | 2020-10-16 |
| CN110167543A (zh) | 2019-08-23 |
| KR20190065296A (ko) | 2019-06-11 |
| MX2019002976A (es) | 2019-07-10 |
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