CN116868306A - 质谱仪的真空腔室中的压强控制 - Google Patents
质谱仪的真空腔室中的压强控制 Download PDFInfo
- Publication number
- CN116868306A CN116868306A CN202280015728.4A CN202280015728A CN116868306A CN 116868306 A CN116868306 A CN 116868306A CN 202280015728 A CN202280015728 A CN 202280015728A CN 116868306 A CN116868306 A CN 116868306A
- Authority
- CN
- China
- Prior art keywords
- pressure
- ion guide
- vacuum stage
- pumped vacuum
- differentially pumped
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 346
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 13
- 230000005672 electromagnetic field Effects 0.000 claims abstract description 8
- 230000005405 multipole Effects 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims description 27
- 238000005070 sampling Methods 0.000 claims description 19
- 238000011144 upstream manufacturing Methods 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 8
- 238000009529 body temperature measurement Methods 0.000 claims description 7
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 230000001276 controlling effect Effects 0.000 claims description 4
- 230000006903 response to temperature Effects 0.000 claims 1
- 239000007789 gas Substances 0.000 description 44
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 18
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 18
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 18
- 229960003147 reserpine Drugs 0.000 description 18
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 18
- 238000005086 pumping Methods 0.000 description 15
- 238000009530 blood pressure measurement Methods 0.000 description 11
- 230000032258 transport Effects 0.000 description 11
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 10
- 230000007423 decrease Effects 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
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- 238000005859 coupling reaction Methods 0.000 description 5
- 238000001819 mass spectrum Methods 0.000 description 5
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000004401 flow injection analysis Methods 0.000 description 4
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- 229960003632 minoxidil Drugs 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 229910052792 caesium Inorganic materials 0.000 description 3
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000004807 desolvation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000037427 ion transport Effects 0.000 description 3
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- -1 reserpine ion Chemical class 0.000 description 3
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- 238000001228 spectrum Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/24—Vacuum systems, e.g. maintaining desired pressures
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163141252P | 2021-01-25 | 2021-01-25 | |
| US63/141,252 | 2021-01-25 | ||
| PCT/IB2022/050562 WO2022157719A1 (en) | 2021-01-25 | 2022-01-21 | Pressure control in vacuum chamber of mass spectrometer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116868306A true CN116868306A (zh) | 2023-10-10 |
Family
ID=80123301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280015728.4A Pending CN116868306A (zh) | 2021-01-25 | 2022-01-21 | 质谱仪的真空腔室中的压强控制 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240087870A1 (ja) |
| EP (1) | EP4281995A1 (ja) |
| JP (1) | JP2024506256A (ja) |
| CN (1) | CN116868306A (ja) |
| WO (1) | WO2022157719A1 (ja) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003102508A1 (en) * | 2002-05-31 | 2003-12-11 | Analytica Of Branford, Inc. | Mass spectrometry with segmented rf multiple ion guides in various pressure regions |
| CA2516264C (en) | 2003-02-14 | 2012-10-23 | Mds Sciex | Atmospheric pressure charged particle discriminator for mass spectrometry |
| US8084736B2 (en) | 2008-05-30 | 2011-12-27 | Mds Analytical Technologies, A Business Unit Of Mds Inc. | Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity |
| US10475633B2 (en) | 2014-11-28 | 2019-11-12 | Dh Technologies Development Pte. Ltd. | RF ion guide |
| CN204464235U (zh) * | 2014-12-31 | 2015-07-08 | 聚光科技(杭州)股份有限公司 | 一种可调真空压力的电感耦合等离子体质谱仪 |
| CN107065950B (zh) * | 2017-03-28 | 2020-10-23 | 清华大学 | 一种基于质谱仪真空腔内气压变化的控制方法 |
| CN111477533B (zh) * | 2020-05-12 | 2024-10-01 | 常州磐诺仪器有限公司 | 用于低真空系统离子产生、传输与质谱联用的装置 |
-
2022
- 2022-01-21 WO PCT/IB2022/050562 patent/WO2022157719A1/en active Application Filing
- 2022-01-21 JP JP2023544288A patent/JP2024506256A/ja active Pending
- 2022-01-21 EP EP22701725.8A patent/EP4281995A1/en active Pending
- 2022-01-21 US US18/273,914 patent/US20240087870A1/en active Pending
- 2022-01-21 CN CN202280015728.4A patent/CN116868306A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024506256A (ja) | 2024-02-13 |
| EP4281995A1 (en) | 2023-11-29 |
| US20240087870A1 (en) | 2024-03-14 |
| WO2022157719A1 (en) | 2022-07-28 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |