CN116850261B - 一种疏郁止咳方剂及其制备方法 - Google Patents
一种疏郁止咳方剂及其制备方法 Download PDFInfo
- Publication number
- CN116850261B CN116850261B CN202310951687.6A CN202310951687A CN116850261B CN 116850261 B CN116850261 B CN 116850261B CN 202310951687 A CN202310951687 A CN 202310951687A CN 116850261 B CN116850261 B CN 116850261B
- Authority
- CN
- China
- Prior art keywords
- cough
- relieving
- prescription
- dispelling
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 89
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 241001673966 Magnolia officinalis Species 0.000 claims abstract description 13
- 235000004347 Perilla Nutrition 0.000 claims abstract description 11
- 244000197580 Poria cocos Species 0.000 claims abstract description 11
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 11
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 9
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 9
- 235000008397 ginger Nutrition 0.000 claims abstract description 9
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 8
- 235000008078 Arctium minus Nutrition 0.000 claims abstract description 8
- 241000931705 Cicada Species 0.000 claims abstract description 8
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 8
- 241000202726 Bupleurum Species 0.000 claims abstract description 6
- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 4
- 240000005528 Arctium lappa Species 0.000 claims abstract 2
- 244000124853 Perilla frutescens Species 0.000 claims abstract 2
- 244000273928 Zingiber officinale Species 0.000 claims abstract 2
- 239000000706 filtrate Substances 0.000 claims description 30
- 238000009835 boiling Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 3
- 235000008216 herbs Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 18
- 208000026435 phlegm Diseases 0.000 abstract description 18
- 208000013116 chronic cough Diseases 0.000 abstract description 13
- 208000024891 symptom Diseases 0.000 abstract description 10
- 230000035945 sensitivity Effects 0.000 abstract description 8
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 7
- 201000007100 Pharyngitis Diseases 0.000 abstract description 7
- 210000004072 lung Anatomy 0.000 abstract description 6
- 230000001717 pathogenic effect Effects 0.000 abstract description 5
- 239000003814 drug Substances 0.000 description 23
- 238000003745 diagnosis Methods 0.000 description 13
- 206010036790 Productive cough Diseases 0.000 description 12
- 210000003800 pharynx Anatomy 0.000 description 11
- 241000229722 Perilla <angiosperm> Species 0.000 description 9
- 210000003802 sputum Anatomy 0.000 description 9
- 208000024794 sputum Diseases 0.000 description 9
- 208000003251 Pruritus Diseases 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 230000007803 itching Effects 0.000 description 8
- 241000234314 Zingiber Species 0.000 description 7
- 241001247821 Ziziphus Species 0.000 description 7
- 235000019658 bitter taste Nutrition 0.000 description 7
- 241000208843 Arctium Species 0.000 description 6
- 206010008479 Chest Pain Diseases 0.000 description 5
- 206010013781 dry mouth Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 206010039101 Rhinorrhoea Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000010753 nasal discharge Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 description 3
- 108090000189 Neuropeptides Proteins 0.000 description 3
- 241001522129 Pinellia Species 0.000 description 3
- 102100024304 Protachykinin-1 Human genes 0.000 description 3
- 208000017574 dry cough Diseases 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000008506 pathogenesis Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 2
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 2
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 description 2
- 241000711573 Coronaviridae Species 0.000 description 2
- 208000007920 Neurogenic Inflammation Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 101800003906 Substance P Proteins 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000009325 pulmonary function Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000000884 Airway Obstruction Diseases 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- 241001248531 Euchloe <genus> Species 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000006751 Platycodon Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 241000238711 Pyroglyphidae Species 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 201000004897 cough variant asthma Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229940046533 house dust mites Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 229930189914 platycodon Natural products 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000010181 skin prick test Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种一种疏郁止咳方剂及其制备方法。所述疏郁止咳方剂，包括以下重量份的组分：柴胡10‑15g、法半夏10g、太子参10g、黄芩10g、生姜10‑15 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。本发明提供的疏郁止咳方剂主治邪郁少阳，痰湿阻肺证引起的咳嗽，具有疏利少阳、燥湿化痰、利咽止咳的功效，该方治疗慢性咳嗽，可以通过降低咳嗽高敏性，减轻临床症状，以达到治疗作用。
Description
技术领域
本发明属于中医制药技术领域，具体涉及一种疏郁止咳方剂及其制备方法。
背景技术
近年来，由于工业化及城市化的不断进展，大气污染等环境问题逐渐突出，加上生活节奏加快,生活压力增加，慢性咳嗽的发病率也呈逐年上升趋势。美国一项研究表明，约40%人口会出现慢性咳嗽。国内相关研究也表明在所有呼吸科就诊患者中，约10%～30%的患者以长期咳嗽为主诉就诊。慢性咳嗽严重影响患者的工作和生活，甚至会引起一些并发症，造成患者许多不必要的经济损失和心理负担。目前对慢性咳嗽的治疗，西医以针对病因治疗为主，针对不同病因已形成诊疗规范，然而我们在临床中仍可见部分患者经过规范检查和治疗后咳嗽症状仍不能改善，治疗效果欠佳，或停药后症状易反复或不良反应大于治疗效果等等问题。而中医论治咳嗽，辨证论治，灵活多变，疗效确凿，尤其对于西医治疗效果差的慢性咳嗽，更能凸显优势，因此充分发挥中医优势以提高临床疗效具有重要意义。
慢性咳嗽发病机制仍不明确，目前越来越多的研究表明，咳嗽高敏感性是其重要的病理生理机制，各种内外因导致的气道神经源性炎症是其发病的重要机制，由P物质（substance P, SP）、神经肽（neurokininA, NKA）、神经肽B（neurokininB, NKB）、降钙素基因相关肽（calcitonin gene-related peptide, CGRP）等神经肽引起的神经源性炎症在慢性咳嗽发病中起重要作用。近年来有研究显示中医药治疗慢性咳嗽的作用机制主要集中在抑制气道炎症，降低咳嗽敏感性。
发明内容
本发明的目的在于提供一种疏郁止咳方剂及其制备方法，从治疗前后患者临床症状、咳嗽敏感性变化等临床指标以评价其临床疗效，进一步研究疏郁止咳方对慢性咳嗽的作用机制，为临床应用提供科学依据。
为实现上述目的，本发明采用如下技术方案：
一种疏郁止咳方剂，包括以下重量份的组分：
柴胡10-15g、法半夏10g、太子参10g、黄芩10g、生姜10-15 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。
所述疏郁止咳方剂的制备方法如下：
1）按原料比例称取各药材，将药材浸泡于500~530mL水中，浸泡时间30~35min；
2）将浸泡后的药材进行一次煎煮，过滤，收集一级滤液和药渣；
一次煎煮过程将药材加热至沸腾，保持微沸直至一级滤液体积为200~210mL；
3）往药渣中加入400~430mL水进行二次煎煮，收集二级滤液；
二次煎煮过程将药渣加热至沸腾，保持微沸直至二级滤液体积为180~190mL；
4）合并一级滤液、二级滤液，得到疏郁止咳方药液，分2次服用。
本发明提供的疏郁止咳方剂主治：邪郁少阳，痰湿阻肺证引起的咳嗽。具有以下功效：疏利少阳，燥湿化痰，利咽止咳。
疏郁止咳方剂适用于以下临床病症：咳嗽、咽痒欲咳、遇风加重，痰白或淡黄，清嗓子或咽喉堵塞感，恶风怕冷、流清涕或鼻后滴流，口干口苦，胸闷脘痞，纳食欠佳，大便偏干或大便溏薄，舌质淡红或红、苔白滑或白腻或白中带黄、脉弦或弦细或滑。
本发明提供的疏郁止咳方剂中，柴胡辛散苦泄，疏散少阳郁滞，黄芩苦寒清泄少阳邪热，二者合用，外透内泄，疏解少阳之邪，共为君；半夏辛温燥湿化痰，降逆止呕，厚朴苦辛温，燥湿消痰，行气开郁，下气除满，半夏与厚朴合用，一化痰结，一行气滞，共为臣；生姜辛散，温中降逆，散寒化饮，苏叶辛温解表散寒，和胃止呕，桔梗辛散苦泄，宣利肺气；茯苓健脾利湿，太子参，生姜、大枣，炙甘草健脾和中；更加蝉蜕祛风解痉利咽，牛蒡子利咽化痰。太子参、生姜、灸甘草、大枣、茯苓、紫苏叶、桔梗、牛蒡子、蝉蜕共为佐使。柴胡、黄芩、厚朴苦降，生姜、半夏、苏叶、桔梗辛开散邪，复有参枣草甘温调补脾胃，诸药合用，清解少阳郁热，下气除满，健脾和中，调达上下，宣通内外，共奏疏利少阳，燥湿化痰，利咽止咳之功。
本发明提供的疏郁止咳方治疗慢性咳嗽，可以通过降低咳嗽高敏性，减轻临床症状，以达到治疗作用。
实施方式
一种疏郁止咳方剂，包括以下重量份的组分：
柴胡10-15g、法半夏10g、太子参10g、黄芩10g、生姜10-15 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。
所述疏郁止咳方剂的制备方法如下：
1）按原料比例称取各药材，将药材浸泡于500~530mL水中，浸泡时间30~35min；
2）将浸泡后的药材进行一次煎煮，过滤，收集一级滤液和药渣；
一次煎煮过程将药材加热至沸腾，保持微沸直至一级滤液体积为200~210mL；
3）往药渣中加入400~430mL水进行二次煎煮，收集二级滤液；
二次煎煮过程将药渣加热至沸腾，保持微沸直至二级滤液体积为180~190mL；
4）合并一级滤液、二级滤液，得到疏郁止咳方药液，分2次服用。
实施例1
一种疏郁止咳方剂，包括以下组分：柴胡10g、法半夏10g、太子参10g、黄芩10g、生姜10 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。
所述疏郁止咳方剂的制备方法如下：
1）将上述药材浸泡于500mL水中，浸泡时间30min；
2）将浸泡后的药材加热至沸腾，保持微沸，然后过滤，收集一级滤液（200mL）和药渣；
3）往药渣中加入400mL水，加热至沸腾，保持微沸，然后过滤收集二级滤液(180mL)；
4）合并一级滤液、二级滤液，得到疏郁止咳药液，分2次服用。
使用实施例1的疏郁止咳药液治疗的典型病例如下：
案例1
患者：蓝某，女，32岁，教师。
2020.04.22初诊：反复咳嗽2月余。缘于患者2月余前始出现咳嗽咳痰，夜间咳甚，遇冷风及刺激性气味时咳嗽加剧，说话时咽痒欲咳，痰量少色白，易咳出，伴咽干咽痒，咽部堵塞感，呼吸不畅感，打喷嚏，曾就诊于漳州当地县医院，查胸片未见明显异常，口服药物（具体不详）后症状未明显改善。辰下：咳嗽，夜间尤甚，痰少色白，咽干咽痒，口干口苦，纳少，寐佳，二便尚调，舌淡红尖有点刺，苔薄白，脉弦细。辅助检查：肺功能：通气功能正常，小气道障碍，支气管激发试验阳性。FeNO：56ppb。皮肤点刺试验：粉尘螨、屋尘螨、蟑螂（+++），蟹肉（++）。西医诊断：咳嗽变异性哮喘，中医诊断：久咳，证属邪郁少阳，痰湿阻肺，治以疏郁止咳方疏利少阳，燥湿化痰，利咽止咳。
处方如下：
柴胡10g 黄芩10g 半夏10g 太子参10g
厚朴10g 茯苓15g 紫苏叶6g 蝉蜕6g
桔梗10g 大枣10g 炙甘草5g 生姜10g 牛蒡子10g
×5剂，水煎服，日1剂，上药味以水500ml先浸泡半小时，煎取200ml，药渣以水400ml,煎取180ml。两次药液混合分2次服。
2020.04.29二诊：患者咳嗽、咽部堵塞感缓解，偶呼吸不畅，遇冷流清涕，无口干口苦，纳可，寐欠安，二便调，舌淡红，苔薄白。效不更方，续予疏郁止咳方加白术、薏苡仁健脾化湿，调理而愈。
实施例2
一种疏郁止咳方剂，包括以下组分：柴胡10g、法半夏10g、太子参10g、黄芩10g、生姜15 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。
所述疏郁止咳方剂的制备方法如下：
1）将上述药材浸泡于500mL水中，浸泡时间30min；
2）将浸泡后的药材加热至沸腾，保持微沸，然后过滤，收集一级滤液（200mL）和药渣；
3）往药渣中加入400mL水，加热至沸腾，保持微沸，然后过滤收集二级滤液(180mL)；
4）合并一级滤液、二级滤液，得到疏郁止咳药液，分2次服用。
使用实施例2的疏郁止咳药液治疗的典型病例如下：
案例2
黄某某，男，49岁
2023.05.24一诊：新型冠状病毒感染后咽痒引咳5月余。患者5月余前不慎感染新冠病毒后遗留咽痒引咳，干咳为主，午后3-5点明显，咳时胸闷，无闻及刺激性气味加剧，多次就诊外院，口服中药（具体不详）后症稍减，但仍迁延，来诊我科。辰下：咽痒，干咳，午后3-5点明显，咳甚胸闷，夜间口苦，纳寐可，二便调。PE：舌偏红苔微黄中厚，脉弦，咽稍充血。辅助检查：肺功能正常，支气管激发试验（-），FeNO：12ppb，咳嗽敏感性试验：C5:125μmol/L。中医诊断：咳嗽，证属邪郁少阳、痰湿阻肺，治以疏郁止咳方疏利少阳，燥湿化痰，利咽止咳。
柴胡10g 黄芩10g 法半夏10g 太子参10g
大枣10g 茯苓15g 紫苏叶6g 厚朴10g
桔梗10g 牛蒡子10g 蝉蜕6g 生姜15g 灸甘草5g
日1剂，水煎服，×5剂。
上药味以水500ml先浸泡半小时，煎取200ml，药渣以水400ml,煎取180ml。两次药液混合分2次服。
2023.05.29二诊：上药后咳嗽减少，夜间干咳，口干，二便调。PE：舌淡红苔薄白，脉弦。守上方，柴胡15g。日1剂，水煎服，煎服法同前。×7剂
2023.06.05三诊：基本无咳嗽，无咳痰，无口干苦，纳寐可，二便调，舌淡红苔薄白脉弦。守疏郁止咳方治疗10天，诸症缓解。复查：咳嗽敏感性试验：C5:250μmol/L，咳嗽敏感性明显降低。
实施例3
一种疏郁止咳方剂，包括以下组分：柴胡10g、法半夏10g、太子参10g、黄芩10g、生姜10 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g。
所述疏郁止咳方剂的制备方法如下：
1）将上述药材浸泡于500mL水中，浸泡时间30min；
2）将浸泡后的药材加热至沸腾，保持微沸，然后过滤，收集一级滤液（200mL）和药渣；
3）往药渣中加入400mL水，加热至沸腾，保持微沸，然后过滤收集二级滤液(180mL)；
4）合并一级滤液、二级滤液，得到疏郁止咳药液，分2次服用。
使用实施例3的疏郁止咳药液治疗的典型病例如下：
案例3
洪某，女，50岁。
2019.08.05初诊：反复咳嗽、咳痰9年余，加剧10天。缘于患者9年余前始出现咳嗽咳痰，清嗓样咳，咽痒即咳，闻及刺激性气味或饮水后即咳，进食寒凉食物即咳，痰量少，色白质稀，咳剧伴清涕，无胸闷气喘，无鼻后滴流，无反酸嗳气，就诊多处服用中药后稍缓解，但仍反复咳嗽。自觉近10天咳嗽咳痰加剧，痰白稀，咽部异物感，口干口苦，纳寐尚可，小便调，大便偏稀，一日一行，舌边尖红苔薄白微黄，脉弦细。查体：咽无充血。辅助检查：胸部CT示肺气肿改变；肺功能检查（2017.9.18））：正常通气功能，支气管激发试验阴性。西医诊断：慢性咳嗽查因；中医诊断：中医诊断：咳嗽，证属邪郁少阳、痰湿阻肺，治以疏郁止咳方疏利少阳，燥湿化痰，利咽止咳。
柴胡10g 黄芩10g 法半夏10g 太子参10g
大枣10g 茯苓15g 紫苏叶6g 厚朴10g
桔梗10g 牛蒡子10g 蝉蜕6g 生姜10g 灸甘草5g
日1剂，水煎服，×5剂。
上药味以水500ml先浸泡半小时，煎取200ml，药渣以水400ml,煎取180ml。两次药液混合分2次服。
2019.08.09二诊：服药后症状好转，咳嗽减轻，痰多白稠，咽痛，偶流清涕，无胸背痛，稍口苦，二便调，舌边尖红苔白厚稍黄。效不更方，续服7剂。
2019.08.23三诊：服药后明显改善，遇风偶有咳嗽，痰少，咽部异物感，稍口苦，二便调，舌淡红苔薄白，续予上方加白术调理而愈。
Claims (3)
1.一种疏郁止咳方剂，其特征在于，由以下重量份的组分组成：
柴胡10-15g、法半夏10g、太子参10g、黄芩10g、生姜10-15 g、灸甘草5g、大枣10g、厚朴10g、茯苓15g、紫苏叶6g、桔梗10g、牛蒡子10g、蝉蜕6g；
所述方剂的制备方法，包括以下步骤：
1）按原料比例称取各药材，将药材浸泡于500~530mL水中，浸泡时间30~35min；
2）将浸泡后的药材进行一次煎煮，过滤，收集一级滤液和药渣；
3）往药渣中加入400~430mL水进行二次煎煮，收集二级滤液；
4）合并一级滤液、二级滤液，得到疏郁止咳方药液，分2次服用。
2.根据权利要求1所述的疏郁止咳方剂，其特征在于，一次煎煮过程将药材加热至沸腾，保持微沸直至一级滤液体积为200~210mL。
3.根据权利要求1所述的疏郁止咳方剂，其特征在于，二次煎煮过程将药渣加热至沸腾，保持微沸直至二级滤液体积为180~190mL。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310951687.6A CN116850261B (zh) | 2023-07-31 | 2023-07-31 | 一种疏郁止咳方剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310951687.6A CN116850261B (zh) | 2023-07-31 | 2023-07-31 | 一种疏郁止咳方剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116850261A CN116850261A (zh) | 2023-10-10 |
| CN116850261B true CN116850261B (zh) | 2024-04-05 |
Family
ID=88230554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310951687.6A Active CN116850261B (zh) | 2023-07-31 | 2023-07-31 | 一种疏郁止咳方剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116850261B (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08208465A (ja) * | 1994-11-11 | 1996-08-13 | Kanebo Ltd | 感冒治療薬 |
| CN103623369A (zh) * | 2013-11-25 | 2014-03-12 | 王纯治 | 一种治疗扁桃体炎、慢性咽炎的中药方剂 |
| CN105056055A (zh) * | 2015-09-25 | 2015-11-18 | 刘瑞云 | 一种治疗咳嗽的药物 |
| CN107281454A (zh) * | 2017-06-23 | 2017-10-24 | 广西中医药大学第附属医院 | 一种咽痒咳合剂及其制备方法 |
| CN109793852A (zh) * | 2019-03-29 | 2019-05-24 | 汪玉冠 | 一种止咳、化痰及平喘的中药组合物 |
| CN110115739A (zh) * | 2018-02-05 | 2019-08-13 | 深圳市瑞莱贵生生物医药科技有限公司 | 一种治疗病毒感染性疾病或咳嗽变异型哮喘的中药组合物及其制备方法 |
-
2023
- 2023-07-31 CN CN202310951687.6A patent/CN116850261B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08208465A (ja) * | 1994-11-11 | 1996-08-13 | Kanebo Ltd | 感冒治療薬 |
| CN103623369A (zh) * | 2013-11-25 | 2014-03-12 | 王纯治 | 一种治疗扁桃体炎、慢性咽炎的中药方剂 |
| CN105056055A (zh) * | 2015-09-25 | 2015-11-18 | 刘瑞云 | 一种治疗咳嗽的药物 |
| CN107281454A (zh) * | 2017-06-23 | 2017-10-24 | 广西中医药大学第附属医院 | 一种咽痒咳合剂及其制备方法 |
| CN110115739A (zh) * | 2018-02-05 | 2019-08-13 | 深圳市瑞莱贵生生物医药科技有限公司 | 一种治疗病毒感染性疾病或咳嗽变异型哮喘的中药组合物及其制备方法 |
| CN109793852A (zh) * | 2019-03-29 | 2019-05-24 | 汪玉冠 | 一种止咳、化痰及平喘的中药组合物 |
Non-Patent Citations (4)
| Title |
|---|
| 小柴胡汤加减治疗儿科疾病验案4则;高军;中医儿科杂志;20130125;09(01);第48-49页 * |
| 小柴胡汤合半夏厚朴汤治疗顽固性咳嗽18例;德成，等;光明中医;20150920;30(09);第1907-1908页 * |
| 洪敏俐治疗感染后咳嗽的临床经验;洪敏俐，等;《中医药通报》;20181231;第17卷(第01期);第22-23, 48页 * |
| 经方治咳嗽验案1则;春松，等;湖南中医杂志;20160528;32(05);第127-128页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116850261A (zh) | 2023-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112353855A (zh) | 中药组合物在制备辅助治疗新型冠状病毒肺炎的药物中的应用 | |
| CN102961573A (zh) | 用于治疗肺间质纤维化的药物及其制备方法 | |
| CN113577140A (zh) | 一种用于治疗新冠肺炎的中药组合物及其制备方法与应用 | |
| CN114732887B (zh) | 一种治疗支气管哮喘的中药组合物 | |
| CN113368207B (zh) | 治疗新冠肺炎恢复期的中药复方及治疗呼吸道感染的应用 | |
| CN102416129A (zh) | 一种用于治疗缓解期慢性阻塞性肺疾病的中药 | |
| CN100418567C (zh) | 一种治疗伤风咳嗽的药物及其制备工艺 | |
| CN116850261B (zh) | 一种疏郁止咳方剂及其制备方法 | |
| CN102274479B (zh) | 一种治疗功能性消化不良的中药组合物 | |
| CN110575529A (zh) | 一种慢支咳喘膏及其制备方法 | |
| CN101966291A (zh) | 治疗急慢性支气管炎和肺结核肺气肿的中草药糖浆 | |
| CN101474373B (zh) | 一种治疗急性咽炎的中药 | |
| CN113713009A (zh) | 一种改善特禀体质的中药组合物及其制备方法和应用 | |
| CN116350741B (zh) | 一种治疗糖尿病胃轻瘫的中药组合物及其制备方法 | |
| CN109793852A (zh) | 一种止咳、化痰及平喘的中药组合物 | |
| CN117244015B (zh) | 一种治疗肺部结节的中药组合物及其应用 | |
| CN115887607B (zh) | 一种因时辨治咳嗽变异性哮喘的中药组合物及其应用 | |
| CN101991730A (zh) | 一种治疗支气管哮喘抗复发的中药复方制剂及其制备方法 | |
| CN117122655A (zh) | 一种清肺化湿方剂及其制备方法 | |
| Zhang | Professor Huang Yahui's Experience in Treating Functional Abdominal Distension through Prescription | |
| CN105535445A (zh) | 一种治疗慢性咽炎的中药制剂及护理方法 | |
| CN115068564A (zh) | 一种治疗慢性咽炎的中药复方 | |
| CN103989909A (zh) | 一种治疗哮喘的中药口服液及其制备方法 | |
| CN118320037A (zh) | 一种清肺定喘的中药组合物及其颗粒药物与应用 | |
| CN117379527A (zh) | 一种用于妊娠反应的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |