CN116850228A - Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof - Google Patents
Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof Download PDFInfo
- Publication number
- CN116850228A CN116850228A CN202311056410.3A CN202311056410A CN116850228A CN 116850228 A CN116850228 A CN 116850228A CN 202311056410 A CN202311056410 A CN 202311056410A CN 116850228 A CN116850228 A CN 116850228A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- pseudo
- ginseng
- ointment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 65
- 244000131316 Panax pseudoginseng Species 0.000 title claims abstract description 64
- 235000003181 Panax pseudoginseng Nutrition 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 34
- 208000014674 injury Diseases 0.000 title claims description 45
- 230000008736 traumatic injury Effects 0.000 title claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 55
- 238000003756 stirring Methods 0.000 claims abstract description 48
- 238000001816 cooling Methods 0.000 claims abstract description 43
- 239000000284 extract Substances 0.000 claims abstract description 37
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 30
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 27
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 25
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 25
- 229960000846 camphor Drugs 0.000 claims abstract description 25
- 229930008380 camphor Natural products 0.000 claims abstract description 25
- 229940041616 menthol Drugs 0.000 claims abstract description 25
- 238000010438 heat treatment Methods 0.000 claims abstract description 22
- 238000002156 mixing Methods 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- 230000000472 traumatic effect Effects 0.000 claims abstract description 13
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 12
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 10
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 9
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract description 9
- 239000000839 emulsion Substances 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 26
- 239000000706 filtrate Substances 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 15
- 241000903946 Clematidis Species 0.000 claims description 14
- 241000628997 Flos Species 0.000 claims description 13
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 13
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 13
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 13
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 12
- 235000021355 Stearic acid Nutrition 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 12
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 12
- 235000011477 liquorice Nutrition 0.000 claims description 12
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 12
- 239000008117 stearic acid Substances 0.000 claims description 12
- 239000003871 white petrolatum Substances 0.000 claims description 12
- 244000144730 Amygdalus persica Species 0.000 claims description 11
- 244000306301 Caesalpinia sappan Species 0.000 claims description 11
- 235000015162 Caesalpinia sappan Nutrition 0.000 claims description 11
- 235000009467 Carica papaya Nutrition 0.000 claims description 11
- 241000195954 Lycopodium clavatum Species 0.000 claims description 11
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 11
- 240000004980 Rheum officinale Species 0.000 claims description 11
- 235000008081 Rheum officinale Nutrition 0.000 claims description 11
- 238000002791 soaking Methods 0.000 claims description 11
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 10
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 241001604597 Pyrestini Species 0.000 claims description 8
- 230000004087 circulation Effects 0.000 claims description 8
- 244000195896 dadap Species 0.000 claims description 8
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 7
- 240000006432 Carica papaya Species 0.000 claims description 6
- 238000000265 homogenisation Methods 0.000 claims description 6
- 229940025250 camphora Drugs 0.000 claims description 5
- 239000010238 camphora Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 4
- 241000218158 Clematis Species 0.000 claims description 2
- 241001116742 Drynaria Species 0.000 claims description 2
- 244000167230 Lonicera japonica Species 0.000 claims description 2
- 235000017617 Lonicera japonica Nutrition 0.000 claims description 2
- 241000972673 Phellodendron amurense Species 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 244000111489 Gardenia augusta Species 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 3
- 240000001972 Gardenia jasminoides Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 description 24
- 230000000052 comparative effect Effects 0.000 description 20
- 230000008859 change Effects 0.000 description 13
- 239000008213 purified water Substances 0.000 description 13
- 229960005150 glycerol Drugs 0.000 description 11
- 238000007599 discharging Methods 0.000 description 10
- 241000157835 Gardenia Species 0.000 description 9
- 238000005303 weighing Methods 0.000 description 9
- 238000004945 emulsification Methods 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 241000219173 Carica Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 235000006264 Asimina triloba Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 235000003143 Panax notoginseng Nutrition 0.000 description 3
- 241000180649 Panax notoginseng Species 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 3
- 238000005325 percolation Methods 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 229950008882 polysorbate Drugs 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 241000125175 Angelica Species 0.000 description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 1
- -1 Hydroxy-phenyl ethyl Chemical group 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of medicines, and particularly discloses a pseudo-ginseng traumatic rheumatism ointment and a preparation method thereof, wherein the preparation method comprises the steps of mixing cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix sileris, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae to obtain mixed medicinal materials, so as to obtain a traditional Chinese medicine extract I; then adding the rest components except camphor and menthol into the traditional Chinese medicine extract I to obtain a traditional Chinese medicine extract II; mixing polysorbate 80, chinese medicinal extract I and Chinese medicinal extract II, and adding water phase adjuvant and water as water phase; heating and uniformly stirring the oil phase auxiliary materials to obtain an oil phase; adding the water phase into the oil phase, homogenizing, and cooling to obtain an emulsion; finally mixing camphor and menthol, heating, adding into the emulsion, homogenizing at high speed, cooling, homogenizing at low speed, and cooling. The ointment prepared by the preparation method has good formability, uniformity, fineness and high stability, and can reduce adhesion on equipment and reduce production loss.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an ointment for treating traumatic injuries and rheumatism and a preparation method thereof.
Background
The pseudo-ginseng traumatic injury rheumatism ointment is a Chinese herbal compound preparation, is composed of 25 Chinese herbal medicines such as pseudo-ginseng, radix angelicae pubescentis, rhizoma drynariae, angelica tail, radix dipsaci, liquorice, radix clematidis and the like, has the effects of activating blood circulation to remove blood stasis, relaxing tendons and activating collaterals, relieving swelling and pain, dispelling wind and removing dampness, is mainly used for treating diseases such as soft tissue injury, rheumatism and lumbago, and has reasonable formula and definite curative effect.
The prior art discloses a preparation method of pseudo-ginseng ointment for treating traumatic injuries: soaking the twenty-five Chinese medicines except menthol, camphor, notopterygium root, radix angelicae pubescentis, angelica tail, radix angelicae, radix dipsaci, fructus gardeniae, herba siegesbeckiae, cortex acanthopanacis and herba Glechomae in ethanol for three days, filtering, recovering ethanol from the filtrate under reduced pressure, and concentrating into thick paste (1) for standby; extracting the residue and the rest thirteen materials such as cortex Erythrinae with 60% ethanol for three days, filtering, recovering ethanol from the filtrate, and concentrating into soft extract (2); heating and filtering vaseline, heating and melting stearic acid and glyceryl monostearate, filtering, and stirring with vaseline to obtain matrix. Adding antiseptic, tween 80 and glycerol into the soft extract (1), mixing, adding distilled water, heating to 80deg.C, filtering, adding into matrix, stirring, cooling to 60deg.C, adding Camphora and Mentholum, stirring, adding the soft extract (2), stirring, and making into 1000g ointment.
However, the production of the pseudo-ginseng ointment for treating traumatic injury has some defects, the disclosed preparation process has no definite auxiliary material dosage and proportion, and has no corresponding index parameter for part of key production parameters, thus causing a certain obstacle to actual production; in addition, the preparation process has the defects that partial feeding sequence is unreasonable, the uniformity of the produced cream is poor, the stability is poor, and the oil-water separation and the like are easy to occur.
So a pseudo-ginseng ointment for treating traumatic injury with good uniformity and high stability and a preparation method thereof are needed at present.
Disclosure of Invention
As used herein, the singular forms "a," "an," and "the" include the singular and plural referents unless the context clearly dictates otherwise. The recitation of numerical ranges by endpoints includes all numbers and fractions subsumed within that corresponding range, and the endpoints recited.
Aiming at the problems existing in the prior art, the invention provides the pseudo-ginseng ointment for treating traumatic injuries and the preparation method thereof, and the pseudo-ginseng ointment for treating traumatic injuries has good formability, uniformity, fineness and greatly improved stability.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the invention provides a preparation method of pseudo-ginseng ointment for treating traumatic injuries,
the pseudo-ginseng ointment for treating traumatic injuries comprises the following components: 37. radix Angelicae Pubescentis, radix Angelicae sinensis, radix Dipsaci, notopterygii rhizoma, fructus Gardeniae, siegesbeckiae herba, cortex Acanthopancis, radix Saposhnikoviae, radix Angelicae Dahuricae, cortex erythrinae, radix Clematidis, herba Glechomae, semen Persicae, radix et rhizoma Rhei, cortex Phellodendri, herba Lycopi, flos Lonicerae, fructus Chaenomelis, glycyrrhrizae radix, herba Lycopodii, rhizoma Drynariae, lignum sappan, mentholum and Camphora;
the preparation method comprises the following steps:
s1, mixing cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix saposhnikoviae, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae to obtain mixed medicinal materials, adding 95% ethanol, forcibly circulating, soaking, filtering to obtain filtrate, and concentrating the filtrate to obtain a traditional Chinese medicine extract I;
s2, firstly grinding pseudo-ginseng into pseudo-ginseng powder, then adding Chinese medicinal extract I into erythrina bark, drynaria rhizome, lonicera japonica, clematis root, herba lycopi, lycopodium clavatum, sappan wood, papaya, peach kernel, rheum officinale, phellodendron bark, liquorice and pseudo-ginseng powder to obtain a mixture, adding 60% ethanol, forcibly circulating, soaking, filtering to obtain filtrate, and concentrating the filtrate to obtain Chinese medicinal extract II;
s3, mixing camphor and menthol and heating to obtain a co-melt;
s4, firstly mixing polysorbate 80, the traditional Chinese medicine extract I and the traditional Chinese medicine extract II, heating and stirring uniformly, and then adding water phase auxiliary materials and water to serve as a water phase; heating and uniformly stirring the oil phase auxiliary materials to obtain an oil phase; adding the water phase into the oil phase, homogenizing, and cooling to obtain an emulsion;
s5, adding the co-melted liquid into the emulsion, homogenizing at a high speed, cooling, homogenizing at a low speed, and cooling to obtain the pseudo-ginseng ointment for treating traumatic injury.
Preferably, in step S1, the feed liquid ratio of the mixed medicinal material to ethanol is 1:8-10; the feed liquid ratio of the mixture to ethanol in the step S2 is 1:4-6.
Preferably, the conditions of the forced circulation in step S1 are: forced circulation is carried out for 10min-30min every 3h-5 h; the conditions of the forced circulation in the step S2 are as follows: forced circulation is carried out for 10min-30min every 3h-5 h.
Preferably, the conditions for the concentration in step S1 are: the temperature is 60-70 ℃; concentrating to relative density of 1.20-1.30.
Preferably, the conditions for the concentration in step S2 are: the temperature is 60-70 ℃; concentrating to relative density of 1.25-1.35.
Preferably, the oil phase auxiliary materials in the step S4 include at least one of stearic acid, glyceryl monostearate and white vaseline; the water phase auxiliary material is glycerin and/or ethylparaben.
Preferably, the mass ratio of stearic acid, glyceryl monostearate and white vaseline is 200-260:280-350:10-30.
Further preferably, the mass ratio of stearic acid, glyceryl monostearate and white vaseline is 220-260:300-350:10-30.
Preferably, the mass ratio of polysorbate 80, glycerin and ethylparaben is 160-200:30-50:2-6.
Preferably, the temperature of the cooling in the step S4 is 50-70 ℃.
Preferably, the conditions of high-speed homogenization in step S5 are: the time is 8min-12min, and the rotating speed is 2000rpm-2500rpm; the conditions of low-speed homogenization are as follows: the time is 10min-20min, and the rotating speed is 800rpm-1000rpm.
Preferably, the temperature of the high-speed homogenization and then the temperature reduction in the step S5 is 40-50 ℃; the temperature of the low-speed homogenized and cooled is 30-40 ℃.
The invention also provides an ointment for treating traumatic injury and rheumatism, which is prepared by the preparation method.
Preferably, the pseudo-ginseng traumatic ointment comprises the following components: 37. radix Angelicae Pubescentis, radix Angelicae sinensis, radix Dipsaci, notopterygii rhizoma, fructus Gardeniae, siegesbeckiae herba, cortex Acanthopancis, radix Saposhnikoviae, radix Angelicae Dahuricae, cortex erythrinae, radix Clematidis, herba Glechomae, semen Persicae, radix et rhizoma Rhei, cortex Phellodendri, herba Lycopi, flos Lonicerae, fructus Chaenomelis, glycyrrhrizae radix, herba Lycopodii, rhizoma Drynariae, lignum sappan, mentholum and Camphora.
Preferably, the composition comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of papaya, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol and 104 parts of camphor.
Compared with the prior art, the invention has the following beneficial effects:
the pseudo-ginseng traumatic rheumatism ointment has good formability, uniformity, fineness and high stability; the invention defines the dosage range of auxiliary materials in the prescription, and plays a guiding role in production; the invention determines the adding sequence of the components, has no bubble generation in the preparation process, is easy to form paste, can reduce the adhesion on equipment, reduces the production loss, and improves the stability of the paste; the invention can further improve the extraction efficiency of the effective components in the pseudo-ginseng traumatic rheumatism ointment and the stability of the ointment by determining the relative density range of the extract and the temperature range when recovering the ethanol under reduced pressure, so that the pseudo-ginseng traumatic rheumatism ointment has better curative effect.
Drawings
FIG. 1 is an appearance of the ointment of example 1 after 6 months of acceleration;
fig. 2 is an appearance characteristic diagram of the pseudo-ginseng traumatic ointment of comparative example 1 after 6 months of acceleration.
Detailed Description
The following description of the present invention is provided by way of specific examples to facilitate understanding and grasping of the technical solution of the present invention, but the present invention is not limited thereto, and the described examples are only some, but not all, examples of the present invention.
The endpoints and any values of the ranges disclosed herein are not limited to the precise range or value, and are understood to encompass values approaching those ranges or values. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.
All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, shall fall within the scope of the invention. The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials, unless otherwise specified, are commercially available.
Example 1A method for preparing ointment from radix Notoginseng for treating traumatic injury
The pseudo-ginseng traumatic rheumatism ointment comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae dahuricae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of pawpaw, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol, 104 parts of camphor, 30 parts of glycerin, 300 parts of glyceryl monostearate, 220 parts of stearic acid, 80160 parts of polysorbate, 2 parts of ethyl hydroxybenzoate, 10 parts of white vaseline and 550 parts of purified water.
The preparation method of the pseudo-ginseng ointment for treating traumatic injuries comprises the following steps:
s1, weighing 10 medicinal materials including cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix saposhnikoviae, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae, sequentially adding into a percolation tank, adding 8 times of 95% ethanol, forcibly circulating for 20 minutes every 4 hours, and discharging after soaking for 3 days. Filtering with 400 mesh filter cloth, concentrating the filtrate at 60deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.20 to obtain Chinese medicinal extract I, and refrigerating.
S2, grinding the medicinal material pseudo-ginseng into coarse powder for later use (40 meshes). Weighing thirteen medicinal materials including cortex erythrinae, rhizoma drynariae, flos lonicerae, radix clematidis, herba lycopi, lycopodium clavatum, sappan wood, papaya, peach kernel, rheum officinale, cortex phellodendri, liquorice and pseudo-ginseng powder, sequentially adding the upper layer of the 1-herb residue of the traditional Chinese medicine extract, adding 4 times of 60% ethanol, forcibly circulating for 20 minutes every 4 hours, soaking for 3 days, and discharging. Filtering with 400 mesh filter cloth, concentrating the filtrate at 60deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.25 to obtain Chinese medicinal extract II, and refrigerating.
S3, weighing camphor and menthol according to the formula, placing the camphor and menthol into a stainless steel barrel, heating in a water bath, stirring until the camphor and menthol are completely melted, and preserving heat for later use.
S4, pretreatment of water phase: placing polysorbate 80, chinese medicinal extract 1 and Chinese medicinal extract 2 into water phase pretreatment pot, heating to 75deg.C, stirring, and mixing. Continuously placing glycerol, ethylparaben and purified water into a pretreatment pot, stirring until all the components are dissolved, and preserving heat for later use;
pretreatment of oil phase: placing stearic acid, white vaseline and glyceryl monostearate into an oil phase pretreatment pot, heating to 75deg.C for melting, stirring to uniformly mix the above components, and keeping the temperature for use.
Emulsification: when the water phase and the oil phase are completely dissolved and the temperature reaches the requirement, a vacuum pump is started, the pretreated oil phase is firstly conveyed into a vacuum emulsifying machine, a stirrer is started to stir (50 rpm), the pretreated water phase is slowly added into the oil phase, standby purified water is taken, a water phase pretreatment pot is cleaned, washing liquid is conveyed into the vacuum emulsifying machine, vacuum is kept, the temperature is kept at 80 ℃, a homogenizer is operated for 15 minutes (2000 rpm), a cooling system of the emulsifying machine is started, and stirring and cooling are carried out.
S5, mixing: when the temperature was lowered to 60 ℃, cooling was stopped, and the co-melt containing camphor and menthol was sucked into a vacuum emulsifying machine, kept under vacuum, and homogenized at high speed for 10 minutes (2200 rpm). And (3) starting a cooling system of the emulsifying machine, stirring and cooling to 45 ℃, homogenizing at a low speed for 10 minutes (1000 rpm), stopping homogenizing, continuing stirring and cooling, cooling to 35 ℃ to form paste, and discharging the paste under low-speed stirring (50 rpm) to obtain the pseudo-ginseng traumatic injury rheumatism ointment.
Example 2 preparation method of an ointment for treating traumatic injury
The pseudo-ginseng traumatic rheumatism ointment comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae dahuricae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of pawpaw, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol, 104 parts of camphor, 40 parts of glycerin, 320 parts of glyceryl monostearate, 240 parts of stearic acid, 80180 parts of polysorbate, 4 parts of ethyl hydroxybenzoate, 20 parts of white vaseline and 500 parts of purified water.
The preparation method of the pseudo-ginseng ointment for treating traumatic injuries comprises the following steps:
s1, weighing 10 medicinal materials including cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix saposhnikoviae, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae, sequentially adding into a percolation tank, adding 9 times of 95% ethanol, forcibly circulating for 30 minutes every 3 hours, and discharging after soaking for 3 days. Filtering with 400 mesh filter cloth, concentrating the filtrate at 65deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.25 to obtain Chinese medicinal extract I, and refrigerating.
S2, grinding the medicinal material pseudo-ginseng into coarse powder for later use (50 meshes). Weighing thirteen medicinal materials including cortex erythrinae, rhizoma drynariae, flos lonicerae, radix clematidis, herba lycopi, lycopodium clavatum, sappan wood, papaya, peach kernel, rheum officinale, cortex phellodendri, liquorice and pseudo-ginseng powder, sequentially adding the upper layer of the 1-herb residue of the traditional Chinese medicine extract, adding 5 times of 60% ethanol, forcibly circulating for 30 minutes every 3 hours, soaking for 3 days, and discharging. Filtering with 400 mesh filter cloth, concentrating the filtrate at 65deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.30 to obtain Chinese medicinal extract II, and refrigerating.
S3, weighing camphor and menthol according to the formula, placing the camphor and menthol into a stainless steel barrel, heating in a water bath, stirring until the camphor and menthol are completely melted, and preserving heat for later use.
S4, pretreatment of water phase: placing polysorbate 80, chinese medicinal extract 1 and Chinese medicinal extract 2 into water phase pretreatment pot, heating to 78deg.C, stirring, and mixing. Continuously placing glycerol, ethylparaben and purified water into a pretreatment pot, stirring until all the components are dissolved, and preserving heat for later use;
pretreatment of oil phase: placing stearic acid, white vaseline and glyceryl monostearate into an oil phase pretreatment pot, heating to 78deg.C for melting, stirring to uniformly mix the above components, and keeping the temperature for use.
Emulsification: when the water phase and the oil phase are completely dissolved and the temperature reaches the requirement, a vacuum pump is started, the pretreated oil phase is firstly conveyed into a vacuum emulsifying machine, a stirrer is started to stir (80 rpm), the pretreated water phase is slowly added into the oil phase, standby purified water is taken, a water phase pretreatment pot is cleaned, washing liquid is conveyed into the vacuum emulsifying machine, vacuum is kept, the temperature is kept at 80 ℃, a homogenizer is operated for 15 minutes (2200 rpm), a cooling system of the emulsifying machine is started, and stirring and cooling are carried out.
S5, mixing: when the temperature was lowered to 50 ℃, cooling was stopped, and the co-melt containing camphor and menthol was sucked into a vacuum emulsifying machine, kept under vacuum, and homogenized at high speed for 8 minutes (2500 rpm). And (3) starting a cooling system of the emulsifying machine, stirring and cooling to 40 ℃, homogenizing at a low speed for 15 minutes (900 rpm), stopping homogenizing, continuing stirring and cooling, cooling to 30 ℃ to form paste, and discharging the paste under low-speed stirring (50 rpm) to obtain the pseudo-ginseng traumatic injury rheumatism ointment.
Example 3 preparation method of an ointment for treating traumatic injury
The pseudo-ginseng traumatic rheumatism ointment comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae dahuricae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of pawpaw, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol, 104 parts of camphor, 50 parts of glycerin, 350 parts of glyceryl monostearate, 260 parts of stearic acid, 80200 parts of polysorbate, 6 parts of ethyl hydroxybenzoate, 30 parts of white vaseline and 440 parts of purified water.
The preparation method of the pseudo-ginseng ointment for treating traumatic injuries comprises the following steps:
s1, weighing 10 medicinal materials including cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix saposhnikoviae, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae, sequentially adding into a percolation tank, adding 10 times of 95% ethanol, forcibly circulating for 10 minutes every 5 hours, and discharging after soaking for 3 days. Filtering with 400 mesh filter cloth, concentrating the filtrate at 70deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.30 to obtain Chinese medicinal extract I, and refrigerating.
S2, grinding the medicinal material pseudo-ginseng into coarse powder for later use (60 meshes). Weighing thirteen medicinal materials including cortex erythrinae, rhizoma drynariae, flos lonicerae, radix clematidis, herba lycopi, lycopodium clavatum, sappan wood, papaya, peach kernel, rheum officinale, cortex phellodendri, liquorice and pseudo-ginseng powder, sequentially adding the upper layer of the 1-herb residue of the traditional Chinese medicine extract, adding 6 times of 60% ethanol, forcibly circulating for 10 minutes every 5 hours, soaking for 3 days, and discharging. Filtering with 400 mesh filter cloth, concentrating the filtrate at 70deg.C under reduced pressure to recover ethanol, concentrating to relative density of 1.35 to obtain Chinese medicinal extract II, and refrigerating.
S3, weighing camphor and menthol according to the formula, placing the camphor and menthol into a stainless steel barrel, heating in a water bath, stirring until the camphor and menthol are completely melted, and preserving heat for later use.
S4, pretreatment of water phase: placing polysorbate 80, chinese medicinal extract 1 and Chinese medicinal extract 2 into water phase pretreatment pot, heating to 80deg.C, and stirring. Continuously placing glycerol, ethylparaben and purified water into a pretreatment pot, stirring until all the components are dissolved, and preserving heat for later use;
pretreatment of oil phase: placing stearic acid, white vaseline and glyceryl monostearate into an oil phase pretreatment pot, heating to 80deg.C for melting, stirring to uniformly mix the above components, and keeping the temperature for use.
Emulsification: when the water phase and the oil phase are completely dissolved and the temperature reaches the requirement, a vacuum pump is started, the pretreated oil phase is firstly conveyed into a vacuum emulsifying machine, a stirrer is started to stir (100 rpm), the pretreated water phase is slowly added into the oil phase, standby purified water is taken, a water phase pretreatment pot is cleaned, washing liquid is conveyed into the vacuum emulsifying machine, vacuum is kept, the temperature is kept at 80 ℃, a homogenizer is operated for 15 minutes (2500 rpm), a cooling system of the emulsifying machine is started, and stirring and cooling are carried out.
S5, mixing: when the temperature was lowered to 70 ℃, cooling was stopped, and the co-melt containing camphor and menthol was sucked into a vacuum emulsifying machine, kept under vacuum, and homogenized at high speed for 12 minutes (2000 rpm). And (3) starting a cooling system of the emulsifying machine, stirring and cooling to 50 ℃, homogenizing at a low speed for 20 minutes (800 rpm), stopping homogenizing, continuing stirring and cooling, cooling to 40 ℃ to form paste, and discharging the paste under low-speed stirring (50 rpm) to obtain the pseudo-ginseng traumatic injury rheumatism ointment.
Comparative example 1 preparation method of an ointment for treating traumatic injury and rheumatism
Compared with example 1, the only difference is that: in the preparation method of the pseudo-ginseng ointment for treating traumatic injury, the concentration temperature in the step S2 is 80 ℃, and the concentration is carried out until the relative density is 1.15, so that the traditional Chinese medicine extract II is obtained. The components and the dosage of the pseudo-ginseng ointment for treating traumatic injuries and other steps in the preparation method are the same as those in the embodiment 1.
Comparative example 2 preparation method of an ointment for treating traumatic injury and rheumatism
Compared with example 1, the only difference is that: in the preparation method of the pseudo-ginseng ointment for treating traumatic injuries, the step S4 and the step S5 are different:
s4, pretreatment of water phase: placing polysorbate 80 and Chinese medicinal extract 1 into water phase pretreatment pot, heating to 75deg.C, stirring, and mixing. Continuously placing glycerol, ethylparaben and purified water into a pretreatment pot, stirring until all the components are dissolved, and preserving heat for later use;
pretreatment of oil phase: placing stearic acid, white vaseline and glyceryl monostearate into an oil phase pretreatment pot, heating to 75deg.C for melting, stirring to uniformly mix the above components, and keeping the temperature for use.
Emulsification: when the water phase and the oil phase are completely dissolved and the temperature reaches the requirement, a vacuum pump is started, the pretreated oil phase is firstly conveyed into a vacuum emulsifying machine, a stirrer is started to stir (50 rpm), the pretreated water phase is slowly added into the oil phase, standby purified water is taken, a water phase pretreatment pot is cleaned, washing liquid is conveyed into the vacuum emulsifying machine, vacuum is kept, the temperature is kept at 80 ℃, a homogenizer is operated for 15 minutes (2000 rpm), a cooling system of the emulsifying machine is started, and stirring and cooling are carried out.
S5, mixing: stopping cooling when the temperature is reduced to 60 ℃, sucking the co-melted liquid containing camphor and menthol into a vacuum emulsifying machine, maintaining vacuum, homogenizing at high speed for 10 minutes (2200 rpm), adding the traditional Chinese medicine extract II, starting a cooling system of the emulsifying machine, homogenizing at low speed for 10 minutes (1000 rpm) when the temperature is reduced to 45 ℃, stopping homogenizing, continuing stirring and cooling, cooling to 35 ℃ to form paste, and discharging the paste under low-speed stirring (50 rpm) to obtain the pseudo-ginseng traumatic rheumatism ointment.
The components and the dosage of the pseudo-ginseng ointment for treating traumatic injuries and other steps in the preparation method are the same as those in the embodiment 1.
Comparative examples 3-5 preparation method of an ointment for treating traumatic injury and rheumatism
Compared with example 1, the only difference is that: the pseudo-ginseng ointment for treating traumatic injuries has different dosages of partial components:
the pseudo-ginseng traumatic rheumatism ointment comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of pawpaw, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol and 104 parts of camphor, and the contents of other components of the pseudo-ginseng traumatic injury ointment in comparative examples 3-5 are shown in the following table.
TABLE 1 content of other Components in comparative examples 3 to 5
| Parts by weight of | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Stearic acid | 120 | 170 | 170 |
| Glyceryl monostearate | 280 | 200 | 150 |
| White vaseline | 20 | 60 | 90 |
| Polysorbate 80 | 170 | 160 | 40 |
| Glycerol | 100 | 50 | 50 |
| Hydroxy-phenyl ethyl ester | 4 | 4 | 2 |
| Purified water | 578 | 628 | 770 |
Comparative examples 3-5 pseudo-ginseng ointment for treating traumatic injuries was prepared in the same manner as in example 1.
Comparative example 6 preparation method of an ointment for treating traumatic injury and rheumatism
Compared with example 1, the only difference is that: in the preparation method of the pseudo-ginseng ointment for treating traumatic injuries, the emulsification in the step S4 is different from that in the step S5:
s4, emulsification: when the water phase and the oil phase are completely dissolved and the temperature reaches the requirement, a vacuum pump is started, the pretreated oil phase is firstly conveyed into a vacuum emulsifying machine, a stirrer is started to stir (50 rpm), the pretreated water phase is slowly added into the oil phase, standby purified water is taken, a water phase pretreatment pot is cleaned, washing liquid is conveyed into the vacuum emulsifying machine, vacuum is kept, the temperature is kept at 80 ℃, stirring is carried out for 10 minutes (50 rpm), a cooling system of the emulsifying machine is started, and stirring and cooling are carried out.
S5, mixing: stopping cooling when the temperature is reduced to 60 ℃, sucking the co-melted liquid containing camphor and menthol into a vacuum emulsifying machine, keeping vacuum, stirring for 10 minutes (50 rpm), cooling to 35 ℃ to form paste, and stirring (50 rpm) to obtain the pseudo-ginseng ointment for traumatic injury and rheumatism.
The components and the dosage of the pseudo-ginseng ointment for treating traumatic injuries and other steps in the preparation method are the same as those in the embodiment 1.
Effect example 1 study of stability Effect of Tianqi Dieda rheumatism ointment
1. Influence of the acceleration test on stability
The ointment prepared in examples 1-3 and comparative examples 1-6 were placed in a drug stability test box (temperature 30+ -2deg.C; relative humidity 65% + -5%) for accelerated test, and samples were taken after 0, 1, 3, and 6 months respectively to examine the properties and uniformity of the ointment. The results are shown in Table 2;
TABLE 2 influence of accelerated test on stability of ointment for treating traumatic injuries of Notoginseng radix
2. Influence of centrifugation on stability
The pseudo-ginseng traumatic injury ointment prepared in the examples 1-3 and the comparative examples 1-6 are respectively placed in a centrifuge tube, and are placed in the centrifuge for centrifugation at 4000rpm for 10min, 20min and 30min, and whether the samples are layered, the matrix is damaged or not is observed. The results are shown in Table 3.
TABLE 3 influence of centrifugal test on stability of ointment for treating traumatic injuries of Notoginseng radix
| Grouping | Centrifuging for 10min | Centrifuging for 20min | Centrifuging for 30min |
| Example 1 | No change | No change | No change |
| Example 2 | No change | No change | No change |
| Example 3 | No change | No change | No change |
| Comparative example 1 | No change | No change | Layering |
| Comparative example 2 | No change | Layering | Layering |
| Comparative example 3 | No change | Layering | Layering |
| Comparative example 4 | Layering | Layering | Layering |
| Comparative example 5 | Layering | Layering | Layering |
| Comparative example 6 | Layering | Layering | Layering |
In conclusion, compared with the comparative example, the pseudo-ginseng ointment for treating traumatic injuries has the advantages of higher stability, good formability, uniformity and fineness, and suitability for industrial production.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (12)
1. A preparation method of an ointment for treating traumatic injury and rheumatism is characterized by comprising the following steps:
the pseudo-ginseng ointment for treating traumatic injuries comprises the following components: 37. radix Angelicae Pubescentis, radix Angelicae sinensis, radix Dipsaci, notopterygii rhizoma, fructus Gardeniae, siegesbeckiae herba, cortex Acanthopancis, radix Saposhnikoviae, radix Angelicae Dahuricae, cortex erythrinae, radix Clematidis, herba Glechomae, semen Persicae, radix et rhizoma Rhei, cortex Phellodendri, herba Lycopi, flos Lonicerae, fructus Chaenomelis, glycyrrhrizae radix, herba Lycopodii, rhizoma Drynariae, lignum sappan, mentholum and Camphora;
the preparation method comprises the following steps:
s1, mixing cortex acanthopanacis, glechomae herba, gardenia, herba siegesbeckiae, radix dipsaci, radix saposhnikoviae, chinese angelica tail, notopterygium root, radix angelicae pubescentis and radix angelicae to obtain mixed medicinal materials, adding 95% ethanol, forcibly circulating, soaking, filtering to obtain filtrate, and concentrating the filtrate to obtain a traditional Chinese medicine extract I;
s2, firstly grinding pseudo-ginseng into pseudo-ginseng powder, then adding Chinese medicinal extract I into erythrina bark, drynaria rhizome, lonicera japonica, clematis root, herba lycopi, lycopodium clavatum, sappan wood, papaya, peach kernel, rheum officinale, phellodendron bark, liquorice and pseudo-ginseng powder to obtain a mixture, adding 60% ethanol, forcibly circulating, soaking, filtering to obtain filtrate, and concentrating the filtrate to obtain Chinese medicinal extract II;
s3, mixing camphor and menthol and heating to obtain a co-melt;
s4, firstly mixing polysorbate 80, the traditional Chinese medicine extract I and the traditional Chinese medicine extract II, heating and stirring uniformly, and then adding water phase auxiliary materials and water to serve as a water phase; heating and uniformly stirring the oil phase auxiliary materials to obtain an oil phase; adding the water phase into the oil phase, homogenizing, and cooling to obtain an emulsion;
s5, adding the co-melted liquid into the emulsion, homogenizing at a high speed, cooling, homogenizing at a low speed, and cooling to obtain the pseudo-ginseng ointment for treating traumatic injury.
2. The method of manufacturing according to claim 1, characterized in that: the feed liquid ratio of the mixed medicinal material to the ethanol in the step S1 is 1:8-10; the feed liquid ratio of the mixture to ethanol in the step S2 is 1:4-6.
3. The method of manufacturing according to claim 1, characterized in that: the conditions of the forced circulation in the step S1 are as follows: forced circulation is carried out for 10min-30min every 3h-5 h; the conditions of the forced circulation in the step S2 are as follows: forced circulation is carried out for 10min-30min every 3h-5 h.
4. The method of manufacturing according to claim 1, characterized in that: the conditions for the concentration in step S1 are: the temperature is 60-70 ℃; concentrating to relative density of 1.20-1.30.
5. The method of manufacturing according to claim 1, characterized in that: the conditions for the concentration in step S2 are: the temperature is 60-70 ℃; concentrating to relative density of 1.25-1.35.
6. The method of manufacturing according to claim 1, characterized in that: the oil phase auxiliary materials in the step S4 comprise at least one of stearic acid, glyceryl monostearate and white vaseline; the water phase auxiliary material is glycerin and/or ethylparaben.
7. The method of manufacturing according to claim 1, characterized in that: the temperature of the cooling in the step S4 is 50-70 ℃.
8. The method of manufacturing according to claim 1, characterized in that: the conditions of the high-speed homogenization in the step S5 are as follows: the time is 8min-12min, and the rotating speed is 2000rpm-2500rpm; the conditions of low-speed homogenization are as follows: the time is 10min-20min, and the rotating speed is 800rpm-1000rpm.
9. The method of manufacturing according to claim 1, characterized in that: the temperature of the high-speed homogenization and then the temperature reduction in the step S5 is 40-50 ℃; the temperature of the low-speed homogenized and cooled is 30-40 ℃.
10. An ointment for treating traumatic injury and rheumatism is characterized in that: prepared by the preparation method of any one of claims 1 to 9.
11. The pseudo-ginseng traumatic ointment according to claim 10, wherein: the pseudo-ginseng ointment for treating traumatic injuries comprises the following components: 37. radix Angelicae Pubescentis, radix Angelicae sinensis, radix Dipsaci, notopterygii rhizoma, fructus Gardeniae, siegesbeckiae herba, cortex Acanthopancis, radix Saposhnikoviae, radix Angelicae Dahuricae, cortex erythrinae, radix Clematidis, herba Glechomae, semen Persicae, radix et rhizoma Rhei, cortex Phellodendri, herba Lycopi, flos Lonicerae, fructus Chaenomelis, glycyrrhrizae radix, herba Lycopodii, rhizoma Drynariae, lignum sappan, mentholum and Camphora.
12. The pseudo-ginseng traumatic ointment according to claim 11, wherein: the composite material comprises the following components in parts by weight: 34 parts of pseudo-ginseng, 70 parts of radix angelicae pubescentis, 70 parts of Chinese angelica tail, 70 parts of radix dipsaci, 70 parts of notopterygium root, 70 parts of gardenia, 70 parts of herba siegesbeckiae, 70 parts of cortex acanthopanacis, 70 parts of radix saposhnikoviae, 138 parts of radix angelicae, 70 parts of erythrina bark, 70 parts of radix clematidis, 70 parts of Glechomae herba, 70 parts of peach kernel, 70 parts of rheum officinale, 70 parts of cortex phellodendri, 70 parts of herba lycopi, 70 parts of flos lonicerae, 70 parts of papaya, 70 parts of liquorice, 70 parts of lycopodium clavatum, 138 parts of rhizoma drynariae, 138 parts of sappan wood, 138 parts of menthol and 104 parts of camphor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311056410.3A CN116850228B (en) | 2023-08-21 | 2023-08-21 | Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311056410.3A CN116850228B (en) | 2023-08-21 | 2023-08-21 | Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116850228A true CN116850228A (en) | 2023-10-10 |
| CN116850228B CN116850228B (en) | 2024-02-06 |
Family
ID=88219325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311056410.3A Active CN116850228B (en) | 2023-08-21 | 2023-08-21 | Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116850228B (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060110468A1 (en) * | 2004-11-24 | 2006-05-25 | Liang Liu | Herbal formulations for arthritis |
| CN101036677A (en) * | 2007-04-02 | 2007-09-19 | 昆明制药集团股份有限公司 | Compound notoginseng cataplasm |
| CN101073635A (en) * | 2006-05-18 | 2007-11-21 | 李雄 | Paste |
| WO2009000150A1 (en) * | 2007-06-21 | 2008-12-31 | Tianjin Tasly Pharmaceutical Co. Ltd. | The use of sanchinoside in treating septicemia |
| CN101347536A (en) * | 2008-09-08 | 2009-01-21 | 广州市荔湾区骨伤科医院 | External-use preparation for treating traumatic injury |
| CN101422552A (en) * | 2007-10-29 | 2009-05-06 | 郭继焕 | Traditional Chinese medicine black plaster capable of activating blood circulation to dissipate blood stasis, knitting bone and alleviating pain and preparation technique thereof |
| CN101485763A (en) * | 2009-02-27 | 2009-07-22 | 青州尧王制药有限公司 | Phellodendron and gardenia Babu plaster |
| CN102188550A (en) * | 2011-05-09 | 2011-09-21 | 广州和华中药研究开发有限公司 | Topical preparation for treating tendon and bone injuries |
| CN102397506A (en) * | 2011-06-30 | 2012-04-04 | 林世银 | Panax notoginseng ostalgia plaster |
| CN107320699A (en) * | 2017-06-30 | 2017-11-07 | 中国中医科学院中药研究所 | A kind of Chinese medicine compound prescription micro emulsion gels and its production and use |
| CN114652808A (en) * | 2022-04-12 | 2022-06-24 | 延吉市王麻子综合门诊部 | Traditional Chinese medicine gel paste for treating osteoarthritis and preparation method thereof |
-
2023
- 2023-08-21 CN CN202311056410.3A patent/CN116850228B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060110468A1 (en) * | 2004-11-24 | 2006-05-25 | Liang Liu | Herbal formulations for arthritis |
| CN101073635A (en) * | 2006-05-18 | 2007-11-21 | 李雄 | Paste |
| CN101036677A (en) * | 2007-04-02 | 2007-09-19 | 昆明制药集团股份有限公司 | Compound notoginseng cataplasm |
| WO2009000150A1 (en) * | 2007-06-21 | 2008-12-31 | Tianjin Tasly Pharmaceutical Co. Ltd. | The use of sanchinoside in treating septicemia |
| CN101422552A (en) * | 2007-10-29 | 2009-05-06 | 郭继焕 | Traditional Chinese medicine black plaster capable of activating blood circulation to dissipate blood stasis, knitting bone and alleviating pain and preparation technique thereof |
| CN101347536A (en) * | 2008-09-08 | 2009-01-21 | 广州市荔湾区骨伤科医院 | External-use preparation for treating traumatic injury |
| CN101485763A (en) * | 2009-02-27 | 2009-07-22 | 青州尧王制药有限公司 | Phellodendron and gardenia Babu plaster |
| CN102188550A (en) * | 2011-05-09 | 2011-09-21 | 广州和华中药研究开发有限公司 | Topical preparation for treating tendon and bone injuries |
| CN102397506A (en) * | 2011-06-30 | 2012-04-04 | 林世银 | Panax notoginseng ostalgia plaster |
| CN107320699A (en) * | 2017-06-30 | 2017-11-07 | 中国中医科学院中药研究所 | A kind of Chinese medicine compound prescription micro emulsion gels and its production and use |
| CN114652808A (en) * | 2022-04-12 | 2022-06-24 | 延吉市王麻子综合门诊部 | Traditional Chinese medicine gel paste for treating osteoarthritis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘小斌，等: "岭南近代著名医家何竹林正骨医粹", 中华中医药学刊, vol. 26, no. 01, pages 2073 - 2074 * |
| 向树明: "田七跌打风湿霜配合三维正脊牵引治疗80例腰椎间盘突出症临床观察", 现代诊断与治疗, no. 20, pages 41 - 42 * |
| 李宁，等: "SPE-RP-HPLC法测定田七跌打风湿软膏中栀子苷的含量", 广东药学院学报, vol. 22, no. 02, pages 144 - 145 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116850228B (en) | 2024-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100525781C (en) | American falx extract, medicinal composition containing it and its making method | |
| CN102526315B (en) | Preparation method of extracts of effective fractions of lychee seeds | |
| CN103834529B (en) | A kind of making method of Wild Buckwheat Rhizome yellow rice wine | |
| CN107890524A (en) | A kind of CHUANBEI PIPA GAO and preparation method thereof | |
| CN103897939A (en) | Wild buckwheat rhizome yellow rice wine brewing technology | |
| CN116850228B (en) | Pseudo-ginseng ointment for treating traumatic injuries and rheumatism and preparation method thereof | |
| CN101530495B (en) | Method for preparing phellodendron extract by applying membrane filtration technology | |
| KR101505103B1 (en) | Improved method for preparing red ginseng extracts using repeated extraction | |
| CN111012810A (en) | Preparation method of unsaponifiable matter in ginseng seed oil | |
| CN106119429A (en) | A kind of production method of Radix Notoginseng sugar | |
| DE102016201562A1 (en) | Chinese medicine for the treatment of tinea pedis and the delivery method thereof | |
| CN1868526A (en) | Soft capsule of active rhizoma gastrodiae, and its prepn. method | |
| CN1590383A (en) | Rod sage root extract and making method of its preparation | |
| CN108969580B (en) | Preparation method and application of blue cloth total tannin | |
| CN112931869A (en) | Camellia oleifera polyphenol composition with blood fat reducing function and preparation method thereof | |
| CN205683636U (en) | Plant extraction liquid extraction equipment | |
| CN1899388A (en) | Shuangdan soft capsule and its preparing method | |
| CN113058011A (en) | Preparation method of traditional Chinese medicine composition for removing impurities by using ceramic membrane | |
| CN106265772B (en) | A kind of ganoderma lucidum concentrated extract preparation method | |
| CN111434345A (en) | Formula and preparation process of moxa essential oil for relieving asthenopia | |
| CN115944672B (en) | Radix aconiti lateralis extract and application thereof | |
| CN107691512A (en) | One kind greening special-purpose insecticide and preparation method thereof | |
| CN105998406A (en) | Compound traditional Chinese medicine paste for treating seborrheic dermatitis and preparation method thereof | |
| CN102475754A (en) | Shenkang soft capsule for treating chronic renal failure and preparation method of Shenkang soft capsule | |
| CN105998405A (en) | Pine needle compound ointment for treating seborrheic dermatitis and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |