CN116832120A - Plaster for preventing and treating thyroid nodule - Google Patents

Plaster for preventing and treating thyroid nodule Download PDF

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Publication number
CN116832120A
CN116832120A CN202310921339.4A CN202310921339A CN116832120A CN 116832120 A CN116832120 A CN 116832120A CN 202310921339 A CN202310921339 A CN 202310921339A CN 116832120 A CN116832120 A CN 116832120A
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parts
preventing
plaster
thyroid nodule
treating thyroid
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周丹妮
齐凤军
徐昌健
姚川
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Hubei College of Chinese Medicine
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Hubei College of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a plaster for preventing and treating thyroid nodule, which comprises the following components: 200 parts of selfheal, 100 parts of kelp, 100 parts of seaweed, 100 parts of burdock, 100 parts of dandelion, 100 parts of blackberry lily, 10 parts of borneol, 100 parts of weeping forsythiae capsule, 100 parts of Chinese violet, 100 parts of radix ranunculi ternati, 100 parts of winged euonymus twig, 100 parts of Ningpo Yam rhizome, 150 parts of Indian iphigenia bulb, 100 parts of snakegourd fruit and 150 parts of thunberg fritillary bulb. The traditional Chinese medicine is prepared from pure traditional Chinese medicines, is safe and nontoxic, has no side effect and no harm to human bodies, is cured by plaster, does not influence normal life of patients, does not take medicine or injection, can achieve the effects of softening hardness and resolving hard mass, can inhibit growth of thyroid nodules, can also play a role in eliminating thyroid nodules, and can play a certain role in goiter, lymphadenectasis and the like.

Description

Plaster for preventing and treating thyroid nodule
Technical Field
The invention relates to the technical field of pharmaceutical compositions, in particular to a plaster for preventing and treating thyroid nodule.
Background
Thyroid nodule is a common disease, and the detection rate of thyroid nodules is increased year by year with the gradual improvement of the B-ultrasonic technology in recent years. Thyroid nodules are detected for their progression in a non-worsening stage, mainly by periodic review or the like, and once a trend of exacerbation is found, surgical resection is performed. However, these methods cannot control the growth of the thyroid nodule, and the side effects of surgical excision are large and expensive, so that an economical, simple and effective method for treating thyroid nodule is currently required by society.
The traditional Chinese medicine accumulates abundant experiences on the treatment of thyroid nodule, has the characteristics of low side effect and stable curative effect, and has great advantages. Traditional Chinese medicine classifies thyroid disorders into the category of "goiter", and thyroid nodules are called "goiter". The treatment is mainly divided into external treatment and internal treatment, and the internal treatment of the traditional Chinese medicine has a certain effect on treating thyroid nodule, but has the limitations that the efficacy of the traditional Chinese medicine is difficult to directly reach lesion sites, the treatment course is long, and the like. So the plaster becomes a good external treatment method.
There are also some thyroid patches currently available on the market to inhibit nodule growth. However, these patches have small effects, cannot inhibit the growth of nodules, and cannot prevent and radically cure the nodules. In addition, most of the thyroid plasters in the market are not pure traditional Chinese medicines, are chemical synthesis agents, are easy to stimulate skin and have no therapeutic effect.
Accordingly, a person skilled in the art provides a plaster for preventing and treating thyroid nodule, so as to solve the problems set forth in the background art.
Disclosure of Invention
The invention aims to provide a plaster for preventing and treating thyroid nodule, which aims to solve the problems in the background technology.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a plaster for preventing and treating thyroid nodule, which comprises the following components: 200 parts of selfheal, 100 parts of kelp, 100 parts of seaweed, 100 parts of burdock, 100 parts of dandelion, 100 parts of blackberry lily, 10 parts of borneol, 100 parts of weeping forsythiae capsule, 100 parts of Chinese violet, 100 parts of radix ranunculi ternati, 100 parts of winged euonymus twig, 100 parts of Ningpo Yam rhizome, 150 parts of Indian iphigenia bulb, 100 parts of snakegourd fruit and 150 parts of thunberg fritillary bulb.
As a further scheme of the invention: the Chinese herbal medicine components are crushed into 200 meshes.
As still further aspects of the invention: the screened medicine powder is ground for three and a half hours at a speed of 3000 times per hour, and the medicine powder ground 10000 times is screened by a 500-mesh screen.
As still further aspects of the invention: mixing the medicinal powder and vaseline in a ratio of 1:1, and repeatedly kneading for 2 hours until the ointment is fine and glossy.
As still further aspects of the invention: the ointment which is uniformly mixed is put into a steam double-layer furnace for multiple times, and is steamed for 5 minutes at high temperature after water is boiled, so that the ointment is uniformly heated.
As still further aspects of the invention: placing all the ointment on a shelf between the cold ointments, wherein the room temperature is about 0-20deg.C, bonding the powder to form a layer, and bonding the Chinese herbal medicine layer with a blank butterfly-shaped patch.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine is prepared from pure traditional Chinese medicines, is safe and nontoxic, has no side effect and no harm to human bodies, is cured by plaster, does not influence normal life of patients, does not take medicine or injection, can achieve the effects of softening hardness and resolving hard mass, can inhibit growth of thyroid nodules, can also play a role in eliminating thyroid nodules, and can play a certain role in goiter, lymphadenectasis and the like.
Drawings
FIG. 1 is a flow chart of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1: a plaster for preventing and treating thyroid nodule, which comprises the following components: 200 parts of selfheal, 100 parts of kelp, 100 parts of seaweed, 100 parts of burdock, 100 parts of dandelion, 100 parts of blackberry lily, 10 parts of borneol, 100 parts of weeping forsythia, 100 parts of viola philippica, 100 parts of radix ranunculi ternati, 100 parts of winged euonymus twig, 100 parts of Ningpo Yam rhizome, 150 parts of Indian iphigenia bulb, 100 parts of snakegourd fruit and 150 parts of thunberg fritillary bulb; the Chinese herbal medicine components are crushed to 200 meshes; grinding the screened medicinal powder for three and half hours at a speed of 3000 times per hour, and sieving the medicinal powder ground 10000 times with a 500-mesh sieve; mixing the medicinal powder and vaseline in a ratio of 1:1, repeatedly kneading for 2 hours until the ointment is fine and glossy; the ointment which is uniformly mixed is put into a steam double-layer furnace for multiple times, and is steamed for 5 minutes at high temperature after boiling water, so that the ointment is uniformly heated; placing all the ointment on a shelf between the cold ointments, wherein the room temperature is about 0-20deg.C, bonding the powder to form a layer, and bonding the Chinese herbal medicine layer with a blank butterfly-shaped patch.
As a limitation of the invention, the genuine medicinal materials with excellent quality are screened, after impurities are removed, the genuine medicinal materials are sent into a cleaning and cleaning pulverizer for preliminary pulverization, the medicine after preliminary pulverization is polished for 3 times by a swing type powder grinder for 1 minute each time, and the polished medicine powder is sieved by a 200-mesh sieve;
mixing the above sieved powder, manually grinding 300g powder in a medicine roller each time, grinding for three and half hours at 3000 times per hour, and sieving 10000 times of powder with 500 mesh sieve;
mixing the sieved medicinal powder uniformly, mixing 600g of medicinal powder and 600g of vaseline each time, and repeatedly kneading for 2 hours until the ointment is fine and glossy;
the ointment which is uniformly mixed is put into a steam double-layer furnace for multiple times, and is steamed for 5 minutes at high temperature after boiling water, so that the ointment is uniformly heated;
placing the above ointment on shelf of the ointment drying room, requiring room temperature to be about 0-20deg.C, bonding powder to form a layer, and bonding the Chinese herbal medicine layer with blank butterfly-shaped application.
When in use, the Chinese herbal medicine layer is stuck to the region where the thyroid gland is positioned (the front part of the neck and the position 2-3 cm below the thyroid cartilage/laryngeal knot) 1 time a day, 2-5 g each time, and is taken down after being stuck for 8 hours.
The traditional Chinese medicine application for preventing and treating thyroid nodule has reasonable compatibility of the components, and can bring the drug effect of the traditional Chinese medicine into play in the application process, so that the traditional Chinese medicine application can achieve the best effect of preventing and treating thyroid nodule.
The invention is suitable for preventing and treating thyroid nodule.
The medicine is prepared from the following medicinal materials:
spica Prunellae: bitter, pungent and cold in flavor. Being pungent in flavor can dispel nodulation and bitter in flavor can dry damp-heat, so it is also dominant. Goiter is a symptom of shaoyang, and it is mainly indicated for shaoyang by Xiao Ku Cao, but is also pungent and dispersed. The Prunella vulgaris contains triterpenes and saponins, sterols, flavonoids, coumarin, organic acids, etc., and has antitumor, antioxidant, antiinflammatory, and immunoregulatory effects. Studies show that the selfheal can play a role in thyroid cancer treatment by inhibiting tumor cell metastasis, promoting apoptosis of the selfheal and inducing apoptosis of thyroid cancer TPC-1 and FTC-133 cell lines and down-regulating B cell lymphoma-2 expression in TC-1 and FTC-133.
Kelp: salty taste, cold taste, and no toxicity. It is used for treating twelve edema, goiter, fistula, and sore. Modern pharmacological research shows that seaweed effective extract plays an anti-tumor role by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, resisting angiogenesis, regulating immunity and the like.
Seaweed: bitter, salty, cold in taste, nontoxic. It is mainly used for treating goiter, cervical and nuclear diseases, resolving hard mass, carbuncle, abdominal mass, hard qi, lower twelve edema. For accumulation and burst between skin, keep qi warm and bind, promote urination.
Fructus Arctii: pungent in flavor, warm in nature, nontoxic, and entering twelve meridians. The main diseases include urticaria and muscles, adverse heat in throat, toxic swelling and sore and ulcer, qi stagnation in waist and knee, lung moistening and cough relieving, qi dispersing and phlegm eliminating. It can eliminate phlegm toxin in neck and wind-heat type dental abscess. The fruit contains arctigenin (arctin), which is hydrolyzed to obtain arctigenin (arctigenin) with anticancer activity.
Dandelion: bitter and sweet in flavor, cold in nature, nontoxic, enters spleen and stomach meridians. It is cool in nature, and can dispel heat-toxin, and is indicated for all kinds of furuncle, carbuncle, abscess and red swelling with heat-toxin, and it is especially indicated for acute mastitis, breast furuncle, red swelling and hard masses.
Blackberry lily: bitter taste, slightly warm nature, toxicity, and entering the three meridians of lung, liver and spleen. Cough with syndrome of adverse qi rising, throat symptoms, appetite stimulating, appetite improving, liver improving, eyesight improving, carbuncle eliminating, toxic materials removing, blood stasis dispelling, menstruation regulating, phlegm accumulation promoting, and tuberculosis self-eliminating.
Borneol: pungent and bitter taste, warm nature, no toxicity, entering lung and liver meridians. Bing pian is pungent and dispersed, so it is indicated for all kinds of diseases, for instance, it is used for treating cold. Modern pharmacological researches have proved that borneol has anti-inflammatory, blood-brain-penetrating, barrier and pathogenic microorganism resisting effects. The external prescription mainly utilizes the functions of anti-inflammation, antibiosis and transdermal absorption promotion, can increase the permeability of biological barriers, and has the mechanisms of loosening skin keratinocytes, widening hair follicle caliber and increasing cell gaps, thereby promoting transdermal absorption.
Fructus forsythiae: bitter in flavor, slightly cold in nature and nontoxic, and enters six meridians of heart, liver, gall bladder, stomach, triple energizer and large intestine. Purges the blood heat of six meridians, dissipates the sores and ulcers of various swelling, benefits the small intestine, kills white worms, relieves menstrual flow, treats five stranguria, breaks gall and solves the acne toxin.
Viola yedoensis makino: bitter and pungent taste, slight cold, and enters the heart of the shaoyin and gallbladder meridian of foot shaoyang. Detumescence toxin, and scabies treatment. Ding Hangjing the recipe is effective in purging pathogenic fire, eliminating swelling, and removing toxic substances, and can be used for treating carbuncle, cellulitis, scrofula, furuncle, and malignant boil. It is good for eating.
Radix Ranunculi Ternati: sweet, pungent and warm. It is indicated for scrofula, phthisis and malaria. It enters liver and lung meridians. The main chemical components of the radix ranunculi ternati are organic acids, saccharides, flavonoids and the like, and have the effects of resisting tumor, tuberculosis, regulating immunity, inhibiting bacteria, protecting liver, resisting oxidation and the like. It was found that the alcohol extract of Ranunculi Ternati, saponin component, fatty acid, etc. can inhibit tumor.
Ramulus Euonymi: bitter and cold in taste and nontoxic. Mainly treats the female collapse, bleeding, abdominal fullness, sweating, eliminating evil, killing the ghost and toxic cup , middle-jiao and bellyache, removing white worms, eliminating skin wind-toxin swelling and resolving yin.
Ningpo Yam rhizome: sweet, bitter and warm. It enters liver, kidney and lung meridians. Dispelling wind and removing dampness, relaxing tendons and dredging collaterals, promoting blood circulation and relieving pain, and relieving cough and asthma. Can be used for treating rheumatalgia, joint swelling, pain and numbness, traumatic injury, lumbar sprain, cough, asthma, malaria, carbuncle, and malignant boil.
Pseudobulbus Cremastrae seu pleiones: sweet and pungent in flavor, qi-calming, entering liver and gallbladder meridian of foot jueyin. Swelling and toxin relieving, hard swelling and resolving hard sore, abscess, scrofula and furuncle due to nodulation. Modern pharmacological studies indicate that Pseudobulbus Cremastrae seu pleiones contains colchicine and has anti-tumor effect.
All snakegourd fruit: sweet and slightly bitter, slightly cold, enter lung meridian of taiyin. Clearing heart fire, moistening lung, washing dirt, relieving restlessness, opening obstruction of chest and diaphragm, removing the adhesive of saliva foam, and most removing blood stasis and turbidity, and relieving the chaise .
Thunberg fritillary bulb: pungent and bitter taste, slightly cold nature, no toxicity, and entering heart and lung meridians. Clearing heart fire, moistening lung, relieving cough, eliminating phlegm, and promoting qi circulation, and can be used for treating chest and abdomen qi adverse flow, typhoid fever, dysphoria, dribbling, abdominal mass hernia, pharyngitis, golden sore, facial sore, goiter, and malignant sore. Modern pharmacological research shows that fritillary bulb has antibacterial, anti-inflammatory and anti-tumor pharmacological effects. Wherein the alkaloid has anti-inflammatory effect by inhibiting the release of inflammatory cytokines by monocytes and lymphocytes; can also down regulate ICAM-1 level, inhibit angiogenesis and cell proliferation, and resist tumor.
The invention has the beneficial effects that: the traditional Chinese medicine patch for preventing and treating thyroid nodule is externally applied, has reasonable compatibility of the components, can bring the drug effect of the traditional Chinese medicine into play in the process of application, and can achieve the best effect of preventing and treating thyroid nodule.
Typical cases:
case 1: some women, 25 years old, patients complain about 1 week ago subjective swelling discomfort in the anterior cervical region, mood anxiety, thyroid color ultrasound: a hypoechoic area of about 0.66 x 0.56cm in size was seen in the left lobe of the thyroid gland, with underscore boundaries, uneven internal echoes, CDFI: a few blood flow signals are visible in the hypoechoic area, and the diagnosis is as follows: thyroid left-lobe solid nodules (TI-RADS 4a class). The paste for preventing and treating thyroid nodule is used for rechecking thyroid color ultrasound after 30 patches are pasted once every other day for 8 hours each time: the hypotonic zone with a size of about 0.66 x 0.48cm is visible in the left lobe of the thyroid gland, and is clear in boundary, uniform in interior and CDFI: no small blood flow signal is found in the hypoechoic area, and the diagnosis is as follows: the left-hand phyllocetic nodules of the thyroid gland (TI-RADS 3a class) had a vanishing sensation of neck swelling.
Case 2: zhang Mou, female, 58 years old, for a "2 day found thyroid nodule" visit, patients complain of 2 day forebody examination with color ultrasound of thyroid gland: thyroid multiple nodules, right hypoechoic nodules approximately 0.8cm x 0.8cm in size, left hypoechoic nodules 0.4cm x 0.3cm in size, thyroid function examination shows: TPO-Ab171.03, the rest is normal, the paste for preventing and treating thyroid nodule is used once every other day for 8 hours, and the paste is re-diagnosed after 45 patches are taken together: color ultrasonic thyroid indicates that the thyroid nodule disappears and the nail function is normal.
The above-described embodiments are merely preferred embodiments of the present invention, and are not intended to limit the present invention in any way, and any equivalent embodiments may be modified or varied by those skilled in the art using the above teachings as teachings. Simple modifications, equivalent changes and adaptations of the above embodiments do not depart from the technical spirit of the invention, and remain within the scope of the invention as defined by the appended claims.

Claims (6)

1. A plaster for preventing and treating thyroid nodule is characterized in that: the application comprises the following components: 200 parts of selfheal, 100 parts of kelp, 100 parts of seaweed, 100 parts of burdock, 100 parts of dandelion, 100 parts of blackberry lily, 10 parts of borneol, 100 parts of weeping forsythiae capsule, 100 parts of Chinese violet, 100 parts of radix ranunculi ternati, 100 parts of winged euonymus twig, 100 parts of Ningpo Yam rhizome, 150 parts of Indian iphigenia bulb, 100 parts of snakegourd fruit and 150 parts of thunberg fritillary bulb.
2. A plaster for preventing and treating thyroid nodule as claimed in claim 1, wherein: the Chinese herbal medicine components are crushed into 200 meshes.
3. A plaster for preventing and treating thyroid nodule as claimed in claim 2, wherein: the screened medicine powder is ground for three and a half hours at a speed of 3000 times per hour, and the medicine powder ground 10000 times is screened by a 500-mesh screen.
4. A patch for preventing and treating thyroid nodule as claimed in claim 3, wherein: mixing the medicinal powder and vaseline in a ratio of 1:1, and repeatedly kneading for 2 hours until the ointment is fine and glossy.
5. The plaster for preventing and treating thyroid nodule according to claim 4, wherein: the ointment which is uniformly mixed is put into a steam double-layer furnace for multiple times, and is steamed for 5 minutes at high temperature after water is boiled, so that the ointment is uniformly heated.
6. A paste for preventing and treating thyroid nodule as claimed in claim 5, wherein: placing all the ointment on a shelf between the cold ointments, requiring room temperature to be about 0-20deg.C, bonding powder to form a layer, and bonding the Chinese herbal medicine layer with a blank butterfly-shaped patch.
CN202310921339.4A 2023-07-26 2023-07-26 Plaster for preventing and treating thyroid nodule Pending CN116832120A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188615A (en) * 2011-04-19 2011-09-21 张海英 Method for treating scrofula
CN108853440A (en) * 2018-09-29 2018-11-23 河南中医药大学 A kind of traditional Chinese medicinal ointment for treating thyroid tumors
CN112717058A (en) * 2021-01-14 2021-04-30 河南中医药大学 External traditional Chinese medicine preparation for treating thyroid nodule and preparation method
CN114306206A (en) * 2021-12-28 2022-04-12 苏州市中医医院 External traditional Chinese medicine composition for treating thyroid nodule and preparation method and application of external traditional Chinese medicine gel plaster

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188615A (en) * 2011-04-19 2011-09-21 张海英 Method for treating scrofula
CN108853440A (en) * 2018-09-29 2018-11-23 河南中医药大学 A kind of traditional Chinese medicinal ointment for treating thyroid tumors
CN112717058A (en) * 2021-01-14 2021-04-30 河南中医药大学 External traditional Chinese medicine preparation for treating thyroid nodule and preparation method
CN114306206A (en) * 2021-12-28 2022-04-12 苏州市中医医院 External traditional Chinese medicine composition for treating thyroid nodule and preparation method and application of external traditional Chinese medicine gel plaster

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