CN116832094A - Compound collateral-activating oil of lignum Dalbergiae Odoriferae - Google Patents

Compound collateral-activating oil of lignum Dalbergiae Odoriferae Download PDF

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Publication number
CN116832094A
CN116832094A CN202310610941.6A CN202310610941A CN116832094A CN 116832094 A CN116832094 A CN 116832094A CN 202310610941 A CN202310610941 A CN 202310610941A CN 116832094 A CN116832094 A CN 116832094A
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essential oil
oil
parts
collateral
compound
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陈宇
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I&D INTERNATIONAL FLAVOURS & FRAGRANCES (GZ) CO LTD
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I&D INTERNATIONAL FLAVOURS & FRAGRANCES (GZ) CO LTD
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The invention discloses a compound collateral-activating oil of dalbergia wood, which belongs to the technical field of health products and comprises the following raw materials in parts by weight: 2 to 5 parts of lobular de-true essential oil, 1 to 3 parts of bergamot essential oil, 0.5 to 1 part of lavender essential oil, 0.2 to 0.5 part of geranium essential oil, 0.2 to 0.5 part of carrot seed essential oil, 0.1 to 0.5 part of rosemary essential oil, 0.1 to 0.5 part of roman chamomile essential oil and 70 to 90 parts of base oil. The invention combines the lobular anti-inflammatory essential oil with various herbal traditional Chinese medicines and pure natural plant essential oil, does not contain any hormone substances, has the effects of fast pain relieving, swelling preventing, antibacterial and anti-inflammatory, has relatively comprehensive effects and has good use effect.

Description

Compound collateral-activating oil of lignum Dalbergiae Odoriferae
Technical Field
The invention belongs to the technical field of health products, and particularly relates to a compound collateral-activating oil of dalbergia wood.
Background
Lignum Dalbergiae Odoriferae (foreign name: agarattan), respectively: reducing blood pressure, lowering blood lipid, lowering blood sugar, lowering blood pressure, belongs to the genus Pterocarpus of the family Leguminosae (Papilionaceae), and comprises two kinds of lignum Dalbergiae Odoriferae and lignum Dalbergiae Odoriferae. The rosewood oil is rich in oil and has fresh and strong fragrance, and mainly has flower fragrance, honey fragrance, musk, orchid fragrance, rosewood fragrance, fruit fragrance, frankincense, medicinal fragrance and the like, and has the theory of one rattan and eight fragrances. The big leaves and the small leaves She Zi are the same family of plants, the big leaves are floral, the small leaves are coconut, and the big leaves and the small leaves are rosewood. The records and application history of the dual-purpose of the rosewood fragrance and the medicine are related in ancient and modern times and the rosewood fragrance has higher potential economic value and application prospect of the dual-purpose of the fragrance and the medicine. Modern medical research proves that the essential oil has three main effects: the elemene has the functions of relieving pain, resisting virus, sterilizing and treating wounds and balsam; secondly, the methyl eugenol has the functions of anesthesia, analgesia, antipyresis and anti-inflammatory; thirdly, the extract contains as many as 23 flavonoid components, has strong functions of resisting oxidization, diminishing inflammation, easing pain, relaxing blood vessels, improving blood circulation, strengthening tendons and bones, delaying aging, resisting tumors, moisturizing skin, removing spots and the like, and also has good repairing function on oxidative damage of nerve cells.
The traditional Chinese medicine oil is a medicinal oil which is developed based on the characteristics of the traditional Chinese medicine and combines the advantages of the production process and the medicinal effect of the traditional Chinese medicine, is used on the surface of the skin, and plays a certain role in treating the skin or the channels. However, the traditional Chinese medicine oil has poor use experience and unpleasant smell. The aromatic essential oil preparation has pleasant smell, and has better experience and skin moistening effect than traditional Chinese medicine oil. The rosewood heart wood has good smell and has the effects of easing pain and resisting inflammation, but the existing essential oil for reducing the blood fat in the market is mostly single essential oil, the effect is single, and when the rosewood heart wood is used, other Chinese medicinal essential oil with coordination and synergy is needed to be additionally added to exert larger and better efficacy.
Disclosure of Invention
In view of the above, the invention provides a compound collateral-activating oil of lignum Dalbergiae Odoriferae, which is prepared by compounding the essential oil of lignum Dalbergiae Odoriferae with various herbal medicines and pure natural plant essential oil, does not contain any hormone substances, has the effects of fast pain relieving, swelling preventing, antibacterial and anti-inflammatory, has relatively comprehensive effects and has good use effect.
The invention is realized by the following technical scheme:
the rosewood heart wood compound collateral-activating oil comprises the following raw materials in parts by weight: 2 to 5 parts of lobular de-true essential oil, 1 to 3 parts of bergamot essential oil, 0.5 to 1 part of lavender essential oil, 0.2 to 0.5 part of geranium essential oil, 0.2 to 0.5 part of carrot seed essential oil, 0.1 to 0.5 part of rosemary essential oil, 0.1 to 0.5 part of roman chamomile essential oil and 70 to 90 parts of base oil.
Further, the base oil is composed of light squalane, olive oil, jojoba oil, and tocopheryl acetate.
Further, the preparation process of the leaflet de-trueness essential oil comprises the following steps:
s1: weighing lignum Dalbergiae Odoriferae log, pulverizing, and sieving to obtain powder sample;
s2: and carrying out normal pressure distillation extraction on the powder sample, and then standing for layering to obtain the leaflet anti-true essential oil.
Further, in step S2, the powder sample is mixed with water and put into a simultaneous distillation extractor for atmospheric distillation extraction.
Further, in step S2, the ratio of the powder sample to water is 1:8.
Further, in step S2, the powder sample was kept boiling at 100 ℃ for 5 hours under normal pressure.
Compared with the prior art, the invention has the following technical effects:
the invention prepares the roselle essential oil, bergamot essential oil, lavender essential oil, geranium essential oil, carrot seed essential oil, rosemary essential oil and roman chamomile essential oil into a compound, and uses vegetable source grease such as olive fruit oil, jojoba oil, vitamin E and the like as base oil for dilution. The essential oils exert the effects and have synergistic effect, and the bergamot essential oil can improve dry, oily and sensitive skin and treat inflammation and eczema; the lavender essential oil can promote cell regeneration and wound healing, and can be used for treating various wounds such as burn, sunburn and the like; the geranium essential oil can promote blood circulation and improve symptoms such as water retention, swelling and the like; regulating hormone secretion, relaxing muscles, improving premenstrual syndrome and climacteric emotion; the rosemary essential oil can astringe skin and has a tightening effect; the roma chamomile essential oil can improve rough skin, dry skin, easy occurrence of acne and the like; relieving sensitive skin and repairing microvascular.
The components of the selected formula of the invention are herbal traditional Chinese medicines and purely natural plants, the essential oil is easy to enter human bodies due to the natural characteristics and small molecules, the compatibility of the medicines is scientific, the preparation process is reasonable, the effective components of the traditional Chinese medicine raw materials are not destroyed, the invention has no toxic or side effect, no addiction and no drug resistance, and the invention has obvious effects on various pains, especially inflammatory pains.
Drawings
FIG. 1 is a flow chart showing the extraction of lignum Dalbergiae Odoriferae in example 1 of the present invention.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the following examples, the following equipments and materials were used:
TABLE 1 apparatus to which the invention relates
Sequence number Device name Model specification
1 Distillation apparatus Laboratory roomAssembly
2 Electronic balance SHINKO G323
3 Constant temperature box Shanghai BoXun BIC-300
The materials used were as follows:
the lobule rosewood log: commercially available inclined She Huangtan
Bergamot essential oil: atdi fragrance (Guangzhou Co., ltd.)
Lavender essential oil: atdi fragrance (Guangzhou Co., ltd.)
Geranium essential oil: atdi fragrance (Guangzhou Co., ltd.)
Carrot seed oil: atdi fragrance (Guangzhou Co., ltd.)
Rosemary essential oil: atdi fragrance (Guangzhou Co., ltd.)
Romaine chamomile essential oil: atdi fragrance (Guangzhou Co., ltd.)
Example 1
The embodiment provides a rosewood heart wood compound collateral-activating oil which comprises the following raw materials in parts by weight: 5 parts of lobular essential oil, 2 parts of bergamot essential oil, 0.75 part of lavender essential oil, 0.35 part of geranium essential oil, 0.35 part of carrot seed oil, 0.3 part of rosemary essential oil, 0.35 part of roman chamomile essential oil, 26 parts of light squalane, 28 parts of olive fruit oil, 18 parts of jojoba oil and 8 parts of tocopherol acetate.
As shown in fig. 1, the preparation process of the leaflet anti-inflammation essential oil specifically comprises the following steps:
s1: weighing 200g of dried log of lignum Dalbergiae Odoriferae with small leaves on an electronic balance, pulverizing, and sieving with a 40-mesh sieve to obtain a powder sample;
s2: placing the powder sample in a round bottom flask of a simultaneous distillation extractor, adding 1600g of distilled water according to a feed liquid ratio of 1:8, soaking for 6 hours, and then boiling and distilling for 5 hours at 100 ℃ under normal pressure to extract volatile components of dalbergia wood;
s3: distilling the sample, standing for layering, and separating oil from water to obtain the essential oil.
The components are added and mixed according to the sequence of the addition amount from large to small, and the compound activating oil is prepared.
Example 2
The embodiment provides a rosewood heart wood compound collateral-activating oil which comprises the following raw materials in parts by weight: 3.5 parts of lobular essential oil, 3 parts of bergamot essential oil, 0.75 part of lavender essential oil, 0.35 part of geranium essential oil, 0.35 part of carrot seed oil, 0.3 part of rosemary essential oil, 0.35 part of Roman chamomile, 26 parts of light squalane, 28 parts of olive fruit oil, 18 parts of jojoba oil and 8 parts of tocopheryl acetate.
The preparation process of the leaflet anti-aliasing essential oil is shown in the example 1.
The raw materials are added and mixed according to the sequence of the addition amount from large to small, and the compound collateral activating oil is prepared.
Example 3
The embodiment provides a rosewood heart wood compound collateral-activating oil which comprises the following raw materials in parts by weight: 3.5 parts of lobular essential oil, 2 parts of bergamot essential oil, 1 part of lavender essential oil, 0.35 part of geranium essential oil, 0.35 part of carrot seed oil, 0.3 part of rosemary essential oil, 0.35 part of roman chamomile, 26 parts of light squalane, 28 parts of olive fruit oil, 18 parts of jojoba oil and 8 parts of tocopheryl acetate.
The preparation process of the leaflet anti-aliasing essential oil is shown in the example 1.
The raw materials are added and mixed according to the sequence of the addition amount from large to small, and the compound collateral activating oil is prepared.
Efficacy tests were performed on compound collateral-activating oils of examples 1-3:
test principle: the adhesive tape made of biological materials such as the simulated stratum corneum and the epidermis simulates the process of smearing cosmetics on human skin, has strong binding force to moisture, and shows good hygroscopicity and moisture retention; good sealing performance, less water loss and strong moisture retention.
The test method comprises the following steps: a piece of 3M bionic adhesive tape with the length of 4.8cm multiplied by 4.8cm is adhered to a glass plate with the length of 5cm multiplied by 5cm to serve as a carrier, 50mg of sample is uniformly smeared on the carrier, the weight of the sample is obtained by weighing, then the sample is placed in a constant temperature and humidity environment for 3 hours, the weight change of the sample is tested, and the moisture absorption rate and the water loss rate are calculated. The test results are shown in Table 2 below.
TABLE 2 test results of Compound collateral-activating oil of example 1
As can be seen from table 2, the comparison of the moisture absorption rate/water loss rate at each stage between the control and the reference sample is considered as follows: the moisture absorption rate of the test object is reduced, the moisture absorption rate of the control is increased, and the moisture absorption rate of the test object is larger than that of the control and has moisture absorption property after 0-6 h; 6-9 hours, the water loss rate of the test object is smaller than that of the control object, and the moisture retention property is achieved; the data from 9 to 24 hours show that the test sample of example 1 has a certain moisturizing effect due to the weak hygroscopicity of the test sample after the water loss stage.
In addition, 60 users with insensitive skin with shoulder and neck, lumbar muscle and joint pain problems or other stiffness problems are selected, trial reactions are carried out on the compound collateral-activating oil effects of the embodiments 1-3, each person trial two products, the two products are respectively used at different positions (twice a day) and are left for 2 weeks, the collection user experience summarization shows that the compound collateral-activating oil prepared in the embodiments 1-3 has the effects of relieving muscle and joint pain, relieving muscle tension stiffness, relaxing emotion, moistening skin and the like. Overall, the user's overall satisfaction with the compound activating oil of example 1 was highest, example 3 being next.
In summary, the invention prepares the rosemary essential oil, the bergamot essential oil, the lavender essential oil, the geranium essential oil, the carrot seed essential oil, the rosemary essential oil, the roman chamomile essential oil and the base oil into a compound, can solve the problem of single function of the rosemary essential oil, provides a reference for the traditional medicine oil, provides an innovative scheme, gives consideration to the experience and the efficacy of the medicine oil, inherits and develops the traditional prescription, and promotes the application and popularization of natural components such as essential oil.
The above description is only a few examples of the present invention and is not intended to limit the embodiments and the protection scope of the present invention, and it should be appreciated by those skilled in the art that equivalent substitutions and obvious changes made by the content of the present invention should be included in the protection scope of the present invention.

Claims (7)

1. The rosewood heart wood compound collateral-activating oil is characterized by comprising the following raw materials in parts by weight: 2 to 5 parts of lobular de-true essential oil, 1 to 3 parts of bergamot essential oil, 0.5 to 1 part of lavender essential oil, 0.2 to 0.5 part of geranium essential oil, 0.2 to 0.5 part of carrot seed essential oil, 0.1 to 0.5 part of rosemary essential oil, 0.1 to 0.5 part of roman chamomile essential oil and 70 to 90 parts of base oil.
2. The rosewood heart wood compound collateral-activating oil according to claim 1, which is characterized by comprising the following raw materials in parts by weight: the essential oil comprises, by weight, 5 parts of lobular essential oil, 2 parts of bergamot essential oil, 0.75 part of lavender essential oil, 0.35 part of geranium essential oil, 0.35 part of carrot seed essential oil, 0.3 part of rosemary essential oil, 0.35 part of Roman chamomile and 80 parts of base oil.
3. The rosewood heart wood compound collateral activating oil of claim 2, wherein said base oil is composed of light squalane, olive oil, jojoba oil, and tocopheryl acetate.
4. The compound dalbergia wood collateral-activating oil of claim 1, wherein the preparation process of the dalbergia wood essential oil comprises the following steps:
s1: weighing lignum Dalbergiae Odoriferae log, pulverizing, and sieving to obtain powder sample;
s2: and carrying out normal pressure distillation extraction on the powder sample, and then standing for layering to obtain the leaflet anti-true essential oil.
5. The compound collateral-activating oil of lignum Dalbergiae Odoriferae of claim 4, wherein in step S2, the powder sample is mixed with water and extracted by distillation under normal pressure in a simultaneous distillation and extraction instrument.
6. The compound dalbergia wood collateral-activating oil of claim 5, wherein in step S2, the ratio of the powder sample to water is 1:8.
7. The compound collateral-activating oil of lignum Dalbergiae Odoriferae of claim 4, wherein in step S2, the powder sample is kept boiling at 100deg.C for 5 hr under normal pressure.
CN202310610941.6A 2023-05-26 2023-05-26 Compound collateral-activating oil of lignum Dalbergiae Odoriferae Pending CN116832094A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005023044A (en) * 2003-07-04 2005-01-27 Nitto Yakuhin Kogyo Kk Aromatic agent
CN109330919A (en) * 2018-11-22 2019-02-15 黄岳娇 A kind of multi-functional pro-skin compound essential oil
CN110624031A (en) * 2019-09-26 2019-12-31 广西鹤兰墨生物科技有限公司 Essential oil for lowering essence, nourishing meridian and health care

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005023044A (en) * 2003-07-04 2005-01-27 Nitto Yakuhin Kogyo Kk Aromatic agent
CN109330919A (en) * 2018-11-22 2019-02-15 黄岳娇 A kind of multi-functional pro-skin compound essential oil
CN110624031A (en) * 2019-09-26 2019-12-31 广西鹤兰墨生物科技有限公司 Essential oil for lowering essence, nourishing meridian and health care

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
冯嘉文;王普兵;杨晓珊;: "精油论述", 广东化工, no. 03, 15 February 2020 (2020-02-15), pages 107 - 108 *

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