CN116829578A - 编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法 - Google Patents

编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法 Download PDF

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Publication number
CN116829578A
CN116829578A CN202280006934.9A CN202280006934A CN116829578A CN 116829578 A CN116829578 A CN 116829578A CN 202280006934 A CN202280006934 A CN 202280006934A CN 116829578 A CN116829578 A CN 116829578A
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CN
China
Prior art keywords
seq
nucleic acid
sequence
polypeptide
hil
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Pending
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CN202280006934.9A
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English (en)
Chinese (zh)
Inventor
许旭
英博
任兆翔
仲夏
蒋玉航
燕化远
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Suzhou Aibo Biotechnology Co ltd
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Suzhou Aibo Biotechnology Co ltd
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Publication of CN116829578A publication Critical patent/CN116829578A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5434IL-12
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5443IL-15
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202280006934.9A 2021-10-08 2022-10-07 编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法 Pending CN116829578A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021122691 2021-10-08
CNPCT/CN2021/122691 2021-10-08
PCT/CN2022/123722 WO2023056915A1 (fr) 2021-10-08 2022-10-07 Polynucléotides codant pour l'interleukine-12 (il-12) et composition associée et procédés associés

Publications (1)

Publication Number Publication Date
CN116829578A true CN116829578A (zh) 2023-09-29

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ID=85803176

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CN202280006934.9A Pending CN116829578A (zh) 2021-10-08 2022-10-07 编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法

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CN (1) CN116829578A (fr)
WO (1) WO2023056915A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023196988A1 (fr) * 2022-04-07 2023-10-12 Modernatx, Inc. Procédés d'utilisation d'arnm codant pour il-12

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101360827A (zh) * 2005-10-20 2009-02-04 国立医学与健康研究所 IL-15Rαsushi结构域作为通过IL-15Rβ/γ的IL-15作用的选择性和有效的增强剂以及超激动剂(IL15Rαsushi-IL15)融合蛋白
CN106755107A (zh) * 2016-11-22 2017-05-31 上海健信生物医药科技有限公司 一种car新分子及其在肿瘤治疗中的应用
CN109195621A (zh) * 2016-05-18 2019-01-11 莫得纳特斯公司 编码白细胞介素12(il12)的多核苷酸及其用途
CN110337305A (zh) * 2017-02-28 2019-10-15 赛诺菲 治疗性rna
CN110964121A (zh) * 2019-12-20 2020-04-07 山东省齐鲁细胞治疗工程技术有限公司 一种分泌il-7、il-15因子的cd19-car-t细胞及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020113403A1 (fr) * 2018-12-04 2020-06-11 Beijing Percans Oncology Co. Ltd. Protéines de fusion de cytokines

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101360827A (zh) * 2005-10-20 2009-02-04 国立医学与健康研究所 IL-15Rαsushi结构域作为通过IL-15Rβ/γ的IL-15作用的选择性和有效的增强剂以及超激动剂(IL15Rαsushi-IL15)融合蛋白
CN109195621A (zh) * 2016-05-18 2019-01-11 莫得纳特斯公司 编码白细胞介素12(il12)的多核苷酸及其用途
CN106755107A (zh) * 2016-11-22 2017-05-31 上海健信生物医药科技有限公司 一种car新分子及其在肿瘤治疗中的应用
CN110337305A (zh) * 2017-02-28 2019-10-15 赛诺菲 治疗性rna
CN110964121A (zh) * 2019-12-20 2020-04-07 山东省齐鲁细胞治疗工程技术有限公司 一种分泌il-7、il-15因子的cd19-car-t细胞及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OFRI LEVI 等: ""Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase"", 《NUCLEIC ACIDS RESEARCH》, vol. 49, no. 1, 10 December 2020 (2020-12-10), pages 432, XP093055848, DOI: 10.1093/nar/gkaa1178 *
莫文苑 等: ""白细胞介素12应用于血液肿瘤免疫治疗研究进展"", 《中国实用内科杂志》, vol. 40, no. 8, 31 August 2020 (2020-08-31), pages 683 - 687 *

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