CN116829578A - 编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法 - Google Patents
编码白细胞介素-12(il-12)的多核苷酸以及其相关组合物和方法 Download PDFInfo
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- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
- QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
- JCZSFCLRSONYLH-QYVSTXNMSA-N wyosin Chemical compound N=1C(C)=CN(C(C=2N=C3)=O)C=1N(C)C=2N3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JCZSFCLRSONYLH-QYVSTXNMSA-N 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- RPQZTTQVRYEKCR-WCTZXXKLSA-N zebularine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N=CC=C1 RPQZTTQVRYEKCR-WCTZXXKLSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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CN2021122691 | 2021-10-08 | ||
CNPCT/CN2021/122691 | 2021-10-08 | ||
PCT/CN2022/123722 WO2023056915A1 (fr) | 2021-10-08 | 2022-10-07 | Polynucléotides codant pour l'interleukine-12 (il-12) et composition associée et procédés associés |
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WO (1) | WO2023056915A1 (fr) |
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WO2023196988A1 (fr) * | 2022-04-07 | 2023-10-12 | Modernatx, Inc. | Procédés d'utilisation d'arnm codant pour il-12 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101360827A (zh) * | 2005-10-20 | 2009-02-04 | 国立医学与健康研究所 | IL-15Rαsushi结构域作为通过IL-15Rβ/γ的IL-15作用的选择性和有效的增强剂以及超激动剂(IL15Rαsushi-IL15)融合蛋白 |
CN106755107A (zh) * | 2016-11-22 | 2017-05-31 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
CN109195621A (zh) * | 2016-05-18 | 2019-01-11 | 莫得纳特斯公司 | 编码白细胞介素12(il12)的多核苷酸及其用途 |
CN110337305A (zh) * | 2017-02-28 | 2019-10-15 | 赛诺菲 | 治疗性rna |
CN110964121A (zh) * | 2019-12-20 | 2020-04-07 | 山东省齐鲁细胞治疗工程技术有限公司 | 一种分泌il-7、il-15因子的cd19-car-t细胞及其应用 |
Family Cites Families (1)
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WO2020113403A1 (fr) * | 2018-12-04 | 2020-06-11 | Beijing Percans Oncology Co. Ltd. | Protéines de fusion de cytokines |
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- 2022-10-07 WO PCT/CN2022/123722 patent/WO2023056915A1/fr active Application Filing
- 2022-10-07 CN CN202280006934.9A patent/CN116829578A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101360827A (zh) * | 2005-10-20 | 2009-02-04 | 国立医学与健康研究所 | IL-15Rαsushi结构域作为通过IL-15Rβ/γ的IL-15作用的选择性和有效的增强剂以及超激动剂(IL15Rαsushi-IL15)融合蛋白 |
CN109195621A (zh) * | 2016-05-18 | 2019-01-11 | 莫得纳特斯公司 | 编码白细胞介素12(il12)的多核苷酸及其用途 |
CN106755107A (zh) * | 2016-11-22 | 2017-05-31 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
CN110337305A (zh) * | 2017-02-28 | 2019-10-15 | 赛诺菲 | 治疗性rna |
CN110964121A (zh) * | 2019-12-20 | 2020-04-07 | 山东省齐鲁细胞治疗工程技术有限公司 | 一种分泌il-7、il-15因子的cd19-car-t细胞及其应用 |
Non-Patent Citations (2)
Title |
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OFRI LEVI 等: ""Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase"", 《NUCLEIC ACIDS RESEARCH》, vol. 49, no. 1, 10 December 2020 (2020-12-10), pages 432, XP093055848, DOI: 10.1093/nar/gkaa1178 * |
莫文苑 等: ""白细胞介素12应用于血液肿瘤免疫治疗研究进展"", 《中国实用内科杂志》, vol. 40, no. 8, 31 August 2020 (2020-08-31), pages 683 - 687 * |
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