CN116818658A - Sample analyzer - Google Patents
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- CN116818658A CN116818658A CN202211662961.XA CN202211662961A CN116818658A CN 116818658 A CN116818658 A CN 116818658A CN 202211662961 A CN202211662961 A CN 202211662961A CN 116818658 A CN116818658 A CN 116818658A
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- 230000007246 mechanism Effects 0.000 claims abstract description 89
- 238000001514 detection method Methods 0.000 claims abstract description 45
- 238000006073 displacement reaction Methods 0.000 claims abstract description 24
- 238000009434 installation Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 238000003384 imaging method Methods 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 238000000386 microscopy Methods 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 230000003044 adaptive effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 25
- 230000008569 process Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 13
- 230000009471 action Effects 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 230000002349 favourable effect Effects 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06166—Line selective sources
- G01N2201/0618—Halogene sources
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/069—Supply of sources
- G01N2201/0692—Regulated sources; stabilised supply
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/123—Conversion circuit
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
- G01N2201/12792—Compensating own radiation in apparatus
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Microscoopes, Condenser (AREA)
Abstract
The application relates to the field of medical equipment, in particular to a sample analyzer. The key points of the technical scheme are as follows: the device comprises a rack, a transparent sample container and a detection unit, wherein the transparent sample container is arranged on the rack and is used for accommodating a sample to be detected; the displacement mechanism is arranged on the frame; the displacement mechanism is arranged below the transparent sample container and is used for driving the micro mechanism to move in the three-dimensional space so as to enable the detection position and focal length between the micro mechanism and the transparent sample container to realize adaptive adjustment.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a sample analyzer.
Background
The microscopy technology is a technology for distinguishing the shape and the characteristics of a tiny object by utilizing an optical system, and is mainly focused on observing cells, molecules or ultrastructures, so that the microscopy technology is widely applied in the medical field.
For example, in the case of performing sample detection on blood, a blood count plate counting method is generally used to detect the number of red blood cells or white blood cells in the related art, and in the detection and analysis process, a corresponding instrument, such as a table microscope, is generally needed, and in the detection and analysis process, firstly, a glass slide titrated with a blood sample is placed at a stage, and then, the focal length of the glass slide and an objective lens is manually adjusted, so that the sample can be observed, thereby obtaining detection data.
However, in the conventional microscope detection process, the position of the glass slide and the focal length of the objective lens often need to be adjusted for multiple times, and the conventional detection mode causes certain limitation on efficient and convenient observation of the sample, so that the observation requirement cannot be well met, and the sample analysis device has a larger improvement space.
Disclosure of Invention
In order to improve convenience in a sample detection process, the application provides a sample analyzer.
The application provides a sample analyzer which adopts the following technical scheme:
the sample analyzer comprises a rack, a transparent sample container, a first detection device and a second detection device, wherein the transparent sample container is arranged on the rack and is used for accommodating a sample to be detected; the displacement mechanism is arranged on the frame; and the microscopic mechanism is arranged below the transparent sample container and is used for driving the microscopic mechanism to move in the three-dimensional space so as to realize adaptive adjustment of the detection position and the focal length between the microscopic mechanism and the transparent sample container.
Through adopting above-mentioned technical scheme, compare in the manual operation of adjusting slide glass and adjusting the focus among the correlation technique, but the microscopic mechanism displacement in the three-dimensional space under the drive of displacement mechanism, but on the one hand automatic adjustment detects the region, reduce the error in the manual adjustment in-process and save the time that the position adjustment was worn in the calibration process many times, in this in-process, transparent sample container can play perspective observation and load the effect of sample, on the other hand, through adjusting the focus, can realize automatic focusing, the action of focusing is more automatic, focusing efficiency is promoted, the convenience in the sample testing process is optimized and improved.
Preferably, the device further comprises a light source mechanism, wherein the light source mechanism is arranged on the frame and is positioned above the transparent sample container, and the light source mechanism, the transparent sample container and the microscopic mechanism are arranged at the same straight line connecting line.
By adopting the technical scheme, the light source mechanism can emit irradiation light towards the transparent sample container, so that the detection sample is developed, and the detection definition and the precision are improved.
Preferably, the light source mechanism comprises a light source part for dispersing the irradiation light, and the light source part is slidably arranged on the rack through the moving part and is used for driving the light source part to be close to or far from the upper side of the transparent sample container.
Through adopting above-mentioned technical scheme, set up light source mechanism into slidable formula structure, when moving light source mechanism to transparent sample container outside, be favorable to replacing transparent sample container, the operation of being convenient for is favorable to shortening the overall structure size of instrument simultaneously.
Preferably, the microscopic mechanism comprises an electron microscope arranged on the displacement mechanism; the light path conversion mirror is connected with the electron microscope; and the lens barrel is connected with the light path conversion lens and used for receiving the imaging light rays from the transparent sample container, and the light path conversion lens is used for refracting the imaging light rays from the lens barrel into the electron microscope.
Through adopting above-mentioned technical scheme, through setting up lens-barrel and light path converter, can prolong the transmission distance of light path, be favorable to adjusting the assembly position between electron microscope and the transparent sample container, further provide the setting space that rises for compact structure.
Preferably, the displacement mechanism comprises a first traversing assembly arranged on the frame and provided with a first sliding table capable of moving back and forth; the second transverse moving assembly is arranged on the first sliding table and provided with a second sliding table capable of moving in a reciprocating manner; and the lifting sliding assembly is arranged on the second sliding table and is provided with a third sliding table capable of lifting and moving, and the microscopic mechanism is arranged on the third sliding table.
By adopting the technical scheme, the lifting sliding component can drive the microscopic mechanism to perform lifting movement so as to adjust the focal length position of the microscopic mechanism and be beneficial to high-definition imaging; meanwhile, the first sideslip subassembly and second sideslip subassembly can play the effect of adjusting microscopic mechanism detection position, and at this in-process, first slip table, second slip table and third slip table three can form stable displacement structure, are favorable to carrying out multiple accurate detection to the different regions of sample.
Preferably, the first traversing assembly comprises a first mounting seat, the first traversing assembly is arranged on the frame, and the first sliding table is slidably arranged on the first mounting seat; the first screw rod is rotatably arranged on the first mounting seat and connected with the first sliding table; and the first driving source is arranged on the first mounting seat, is connected with the first screw rod and is used for driving the first screw rod to rotate.
Through adopting above-mentioned technical scheme, under the drive effect of first actuating source, first lead screw rotates, and first mount pad provides the slip direction effect for first slip table this moment, drives first slip table and makes straight reciprocating motion.
Preferably, the second traversing assembly comprises a second mounting seat, the second traversing assembly is arranged on the first traversing assembly, and the second sliding table is slidably arranged on the second mounting seat; the second screw rod is rotatably arranged on the second installation seat and is connected with the second sliding table; and the second driving source is arranged on the second mounting seat, is connected with the second screw rod and is used for driving the second screw rod to rotate.
Through adopting above-mentioned technical scheme, under the drive effect of second actuating source, the second lead screw rotates, and the second mount pad provides the slip direction effect for the second slip table this moment, drives the second slip table and makes straight reciprocating motion.
Preferably, the lifting sliding assembly comprises a third mounting seat, the third sliding table is arranged on the second transverse moving assembly in a sliding manner, and the third sliding table is arranged on the third mounting seat in a sliding manner; the third screw rod is rotatably arranged on the third installation seat and is connected with the third sliding table; and the third driving source is arranged on the third mounting seat, is connected with the third screw rod and is used for driving the third screw rod to rotate.
Through adopting above-mentioned technical scheme, under the drive effect of third actuating source, the third lead screw rotates, and the third mount pad provides the slip direction effect for the third slip table this moment, drives the third slip table and goes up and down reciprocating motion.
Preferably, the transparent sample container comprises a transparent base having a receiving cavity for receiving a detection reagent; and the transparent cover body is used for accommodating samples, is connected with the transparent base, is internally provided with capillary holes for quantitatively retaining the samples, and the capillary holes are communicated with the accommodating cavity and are mutually communicated with at least two groups of accommodating cavities.
Through adopting above-mentioned technical scheme, multiunit intercommunicated holding chamber and capillary hole carry out different project test to different samples, and at this moment, cooperation movable microscopic mechanism realizes multiunit data continuous detection, and a plurality of data index is obtained swiftly to the high efficiency, and in addition, the capillary hole can quantitatively draw appropriate amount of sample, is favorable to promoting the accuracy nature in the follow-up testing process.
Preferably, the rack is provided with a positioning hole, a positioning convex part is arranged at the hole wall of the positioning hole, a positioning concave part which is in plug-in fit with the positioning convex part is arranged at the transparent sample container, and the transparent sample container is arranged at the positioning convex part through the positioning concave part.
Through adopting above-mentioned technical scheme, the locating hole can play the effect of carrying out the location all around to transparent sample easily, cooperates the location convex part, can carry out the bearing to transparent sample container, realizes transparent sample container's location, and transparent sample container's position accuracy obtains promoting.
In summary, the present application includes at least one of the following beneficial technical effects:
1. under the drive of the displacement mechanism, the microscopic mechanism can displace in the three-dimensional space, errors in the manual adjustment process are reduced, time consumed in the position multiple adjustment and correction process is saved through automatically adjusting the detected area, in addition, automatic focusing can be realized through automatically adjusting the position of the microscopic mechanism, focusing action is more automatic, focusing efficiency is improved, and convenience in the sample detection process is optimized and improved;
2. the light source can develop the detection sample, so that the detection definition and the precision are improved, and the light source mechanism is set to be in a movable form, so that the light source mechanism can be moved to the outside of the transparent sample container, and the transparent sample container can be replaced conveniently;
3. the transparent sample container is provided with a plurality of groups of mutually communicated accommodating cavities and capillary holes, and can accommodate different detection items so as to realize differential tests on different samples, and at the moment, the transparent sample container is matched with a movable microscopic mechanism to realize continuous detection of a plurality of groups of data and efficiently and quickly obtain a plurality of data indexes.
Drawings
FIG. 1 is a schematic diagram of a sample analyzer according to a preferred embodiment of the present application.
FIG. 2 is a schematic view of a transparent sample container according to a preferred embodiment of the present application.
FIG. 3 is a cross-sectional view of a transparent sample container in accordance with a preferred embodiment of the present application.
FIG. 4 is a schematic view of the positioning hole and the positioning protrusion according to a preferred embodiment of the present application.
FIG. 5 is a schematic view of a first traverse assembly according to a preferred embodiment of the present application.
FIG. 6 is a schematic view of the first traversing assembly and the second traversing assembly according to a preferred embodiment of the present application.
FIG. 7 is a schematic view of a displacement mechanism according to a preferred embodiment of the present application.
Fig. 8 is a schematic view of a frame and a light source mechanism according to a preferred embodiment of the application.
Reference numerals illustrate:
1. a frame; 11. a base; 12. a support frame; 13. a top plate; 14. positioning holes; 141. positioning convex parts;
2. a transparent sample container; 21. a transparent base; 211. a receiving chamber; 212. a positioning concave part; 22. a transparent cover; 221. capillary holes;
3. a displacement mechanism;
31. a first traversing assembly; 311. a first sliding table; 312. a first mount; 313. a first screw rod; 314. a first driving source;
32. a second traversing assembly; 321. a second sliding table; 322. a second mounting base; 323. a second screw rod; 324. a second driving source;
33. a lifting sliding component; 331. a third sliding table; 332. a third mount; 333. a third screw rod; 334. a third driving source;
4. a microscopy mechanism; 41. an electron microscope; 42. an optical path conversion mirror; 43. a lens barrel;
5. a light source mechanism; 51. a light source section; 52. a moving part; 521. a carriage; 522. a slide rail.
Detailed Description
The application is described in further detail below with reference to fig. 1-8.
The embodiment of the application discloses a sample analyzer.
Referring to fig. 1, the analyzer comprises a frame 1, a transparent sample container 2, a displacement mechanism 3, a microscopic mechanism 4 and a light source mechanism 5, wherein the transparent sample container 2 is arranged at the frame 1 and is used for accommodating a sample to be detected; the displacement mechanism 3 is disposed at the frame 1, the micro-mechanism 4 is disposed at the displacement mechanism 3, the micro-mechanism 4 is used for detecting a detection sample, the displacement mechanism 3 is used for driving the micro-mechanism 4 to move in a three-dimensional space so as to realize a series of actions such as automatic switching of a detection area and automatic focusing, and in this embodiment, for convenience of description of the three-dimensional azimuth, a three-dimensional coordinate system is set, and three groups of directions are respectively defined as an x direction, a y direction and a z direction.
The rack 1 plays a role in providing assembly positions for all mechanisms, in this embodiment, in order to meet the overall compactness of the instrument, the rack 1 mainly comprises a base 11, a support frame 12, a top plate 13 and other structures in this embodiment, the support frame 12 is vertically arranged and fixedly mounted at the top of the base 11, the top plate 13 is fixedly mounted at the top of the support frame 12, at this time, a containing cavity 211 is formed between the top plate 13 and the bottom plate, and the containing cavity 211 can be used for containing the displacement mechanism 3 and the microscopic mechanism 4 so as to achieve the effect of compact structure. At this time, the transparent sample container 2 is detachably arranged at the top plate 13, and the microscopic mechanism 4 performs detection analysis on the transparent sample container 2 from bottom to top.
Referring to fig. 2 and 3, in order to accommodate a sample and to improve the overall efficiency in the sample detection process, in this embodiment, the transparent sample container 2 includes a transparent base 21 and a transparent cover 22, the transparent base 21 is in a flat box structure in this embodiment, the interior of the transparent base 21 has an accommodating cavity 211, the accommodating cavity 211 is in a strip cavity structure in this embodiment, one end of the accommodating cavity 211 is open at one side of the transparent base 21, and at this time, a corresponding detection reagent can be injected into the accommodating cavity 211 through the opening of the accommodating cavity 211, so as to implement retention of the detection reagent in the transparent base 21.
Meanwhile, the transparent cover 22 is used for accommodating samples, the overall structure outline of the transparent cover 22 is similar to that of the transparent base 21, the transparent cover 22 can be integrally provided with a buckling flange at the edge, the transparent cover 22 is buckled to the edge of the transparent base 21 through the buckling flange, the detachable connection between the transparent cover 22 and the transparent base 21 is realized, at the moment, the transparent cover 22 seals one end of the opening of the accommodating cavity 211, and the transparent cover 22 is positioned right above the transparent base 21 in a normal use state.
In addition, the capillary holes 221 are formed in the transparent cover 22 in a penetrating manner, the transparent cover 22 can be made of hydrophilic materials, the capillary holes 221 penetrate through the upper end and the lower end of the transparent cover 22, the bottom ends of the capillary holes 221 are communicated with the opening of the accommodating cavity 211, at the moment, when the sample is dropped to the position, far away from the transparent base 21, of the transparent cover 22, the sample can infiltrate into the capillary holes 221, and the sample flowing into the capillary holes 221 can be quantitatively reserved due to the small size of the capillary holes 221, and then the sample positioned in the capillary holes 221 can flow into the accommodating cavity 211 by swinging the transparent sample container 2 and react with a detection reagent, so that the sample is processed and is convenient for subsequent observation.
In view of this, in the process of sample detection, multiple detection reagents are often required to react with different samples so as to observe different cell types, at this time, a transparent sample to be detected needs to be replaced for multiple times, so that multiple replacement operations may lead to a decrease in detection efficiency, and in this embodiment, at least two groups of the accommodating cavities 211 and capillary holes 221 that are mutually communicated, for example, three groups, four groups, five groups or more groups, are provided, and by providing multiple groups of the accommodating cavities 211 and capillary holes 221 that are mutually communicated, multiple samples can be detected at the same time when the transparent sample container 2 is assembled once, so as to provide a possibility for improving detection efficiency; in the present embodiment, the accommodating chambers 211 and the capillary holes 221 that are mutually communicated are set to seven groups for illustration, and the specific number of the arrangement can be correspondingly adjusted according to the actual detection requirement, which is not particularly limited herein.
Referring to fig. 2 and 4, in the process of performing sample detection, if the sample is placed and shifted, the shift of the detection area is caused, and stability in sample placement is an important precondition for sample detection accuracy; based on this, the rack 1 can function as an auxiliary for stable placement of the sample. Specifically, the frame 1 is provided with a positioning hole 14, the positioning hole 14 is arranged on the top plate 13 in a penetrating manner along the vertical direction, the outline of the opening of the positioning hole 14 is consistent with the outline of the transparent sample container 2, the transparent sample container 2 is placed in the positioning hole 14, and the hole wall of the positioning hole 14 can be attached to the outline of the outer edge of the transparent sample container 2, so that the transparent sample container 2 is not easy to deviate in the horizontal direction.
Meanwhile, a positioning convex part 141 is integrally connected to the hole wall of the positioning hole 14, and the positioning convex part 141 extends towards the inside of the positioning hole 14; the transparent sample container 2 has a positioning concave portion 212 in plug-fit with the positioning convex portion 141, specifically, the positioning concave portion 212 is concavely provided at the peripheral edge position of the transparent base 21, and at this time, the transparent base 21 is in a stepped structure, the positioning convex portion 141 is inserted into the positioning concave portion 212 when the transparent sample is to be accommodated in the positioning hole 14, and the transparent base 21 is placed on the positioning convex portion 141 through a stepped portion formed by the inward recess, at this time, with the top face of the positioning convex portion 141 as a reference, the transparent sample container 2 is stably positioned in the vertical direction.
After the transparent sample container 2 is placed on the rack 1, the sample is then observed by the displacement mechanism 3 and the microscopy mechanism 4. Specifically, the displacement mechanism 3 includes a first traversing assembly 31, a second traversing assembly 32, and a lifting and sliding assembly 33 that are sequentially connected.
Referring to fig. 5, specifically, the first traversing assembly 31 includes a first sliding table 311, a first mounting seat 312, a first screw 313, and a first driving source 314, where the first mounting seat 312 has a long frame structure in the present embodiment, and the first mounting seat 312 is fixedly mounted at the base 11 of the frame 1 along the horizontal direction; meanwhile, the length direction of the first mount 312 is consistent with the x direction; the first lead screw 313 is disposed along a horizontal direction, a length direction of the first lead screw 313 is identical to an x direction, two ends of the first lead screw 313 are rotatably mounted on the first mounting seat 312 through bearings, and at this time, the first lead screw 313 can rotate on the first mounting seat 312.
The first driving source 314 is used for outputting power, and specifically, the first driving source 314 may be selected from a motor, a hydraulic motor, or other elements, and any element capable of outputting torque may be selected and used without limitation. The first driving source 314 is fixedly installed at the first installation seat 312, and an output shaft of the first driving source 314 is connected with one end of the first screw rod 313 through a coupling, at this time, the first driving source 314 is started to drive the screw rod to rotate, and along with the change of the torque direction output by the first driving source 314, the first screw rod 313 can be driven to rotate forward or backward.
Meanwhile, the first sliding table 311 is slidably disposed at the first mounting seat 312; wherein, a first sliding groove is formed on the first mounting seat 312, the first sliding groove extends along the length direction of the first mounting seat 312, the first sliding table 311 is slidingly matched to the first sliding groove, the first sliding table 311 can move along the x direction under the guidance of the first sliding groove, at this time, a threaded hole for the first screw rod 313 to be in threaded connection is formed at the first sliding table 311, and the first sliding table 311 can reciprocate along the x direction under the pushing of the first screw rod 313.
Referring to fig. 6, the second traverse assembly 32 is disposed at the first sliding table 311, the first traverse assembly 31 can drive the second traverse assembly 32 to reciprocate along the x direction, and specifically, the structure of the second traverse assembly 32 is similar to that of the first traverse assembly 31, and the second traverse assembly 32 includes a second sliding table 321, a second mounting seat 322, a second screw 323 and a second driving source 324. The structure of the second mounting seat 322 is similar to that of the first mounting seat 312, the second mounting seat 322 is fixedly mounted at the first sliding table 311, the length direction of the second mounting seat 322 is consistent with the y direction, the second screw rod 323 is rotatably mounted at the second mounting seat 322 through the bearing seat, the length direction of the second screw rod 323 is also set along the y direction, the second driving source 324 is selected as a motor element, the second driving source 324 is fixedly mounted at the frame 1, an output shaft of the second driving source 324 is connected with the second screw rod 323 through a coupler, and at the moment, the second driving source 324 is started to rotate the second screw rod 323.
Meanwhile, the second installation seat 322 is provided with a second sliding groove, the second sliding groove also extends along the length direction of the second installation seat 322, the second sliding table 321 is slidably arranged at the second installation seat 322 through the second sliding groove, the second installation seat 322 is provided with a threaded hole in a penetrating mode, the threaded hole is used for enabling the second screw rod 323 to be in threaded connection, and the second sliding table 321 can slide back and forth along the y direction under the driving of the second screw rod 323.
It should be noted that, in the actual assembly, if the second traverse assembly 32 is directly assembled to the first sliding table 311, the height of the structure may be accumulated, because the lifting space is further required to be provided for the lifting sliding assembly 33, after the lifting sliding assembly 33 is installed, the overall structure of the analyzer may be excessively high, which further may result in an insufficiently compact structure and a waste of space. Based on this, in the present embodiment, the first sliding table 311 and the second sliding table 321 are both in a plate-shaped structure, and one side of the first sliding table 311 extends to the outside of the first mounting seat 312, and at this time, a receiving space is formed between the first sliding table 311 and the base 11.
Then set up the accommodation space department of second mount pad 322, second lead screw 323 and second drive source 324 below first slip table 311, run through on first slip table 311 this moment and be provided with dodge the hole, with the vertical setting of second slip table 321 to extend to first slip table 311 top with second slip table 321 via dodging the hole, the position area after second slip table 321 passed dodges the hole can provide the mounted position for lift slip assembly 33 just, and the overall compactness of structure can promote.
Referring to fig. 7, based on this, the lifting and sliding assembly 33 is disposed at the second sliding table 321, and the first traversing assembly 31 and the second traversing assembly 32 are mutually matched to drive the lifting and sliding assembly 33 to translate on the horizontal plane, so as to realize the position adjustment of the lifting and sliding assembly 33; on the one hand, the micro mechanism 4 can be adjusted to be right below different detection positions of the transparent sample container 2 by moving on a horizontal plane, so that sequential synchronous detection of multiple groups of samples is realized; on the other hand, the lifting sliding component 33 can drive the micro mechanism 4 to do lifting motion, so that the focal length between the micro mechanism 4 and the transparent sample container 2 is automatically adjusted, and accurate imaging of a sample is facilitated.
Specifically, in order to realize the lifting focusing action of the microscope mechanism 4, the lifting sliding assembly 33 includes a third sliding table 331, a third mounting seat 332, a third screw 333, and a third driving source 334, where the third mounting seat 332 is in a bracket structure, and the third mounting seat 332 is fixedly mounted on one side of the second sliding table 321; the third driving source 334 is used for outputting torque, and specifically may be selected from a motor or a hydraulic motor, and in this embodiment, a motor is selected as an example; correspondingly, the third screw rod 333 is arranged along the vertical direction, the third screw rod 333 is rotatably mounted at the third mounting seat 332 through a bearing, an output shaft of the third screw rod 333 is connected with the third driving source 334 through a coupler, and the third driving source 334 is started to drive the third screw rod 333 to rotate.
Then, a guide rail can be additionally arranged at the third installation seat 332, the guide rail is arranged in the vertical direction, the third sliding table 331 is slidably arranged at the third installation seat 332 through the guide rail, a threaded hole is formed in the third installation seat 332 at this time, the third screw 333 is in threaded connection with the third installation seat 332 through the threaded hole, the third sliding table 331 can be driven to conduct lifting motion in the process of rotating the third screw 333, the microscopic mechanism 4 is arranged at the third sliding table 331, and at this time, the lifting sliding assembly 33 can achieve lifting motion of the microscopic mechanism 4.
With continued reference to fig. 7, in order to implement microscopic examination of a sample, the microscope mechanism 4 includes an electron microscope 41, an optical path changing mirror 42 and a lens barrel 43, where the electron microscope 41 is fixedly mounted on the third sliding table 331, the electron microscope 41 may be a miniature or small-sized electron microscope, but the length of the electron microscope 41 is usually longer, and the electron microscope 41 is usually vertically arranged directly according to a conventional mounting manner, but if the electron microscope 41 is vertically arranged, a larger height space is occupied, and a certain influence is caused on the structural compactness of the instrument. To overcome the above-described technical problems, in the present embodiment, the electron microscope 41 is disposed in the horizontal direction to further compress the assembled space, improving the structural compactness.
Based on this, in order to secure sample imaging, the optical path conversion mirror 42 and the lens barrel 43 are required. The light path conversion mirror 42 is fixedly installed on the electron microscope 41 and is close to the incident end, and the light path conversion mirror 42 mainly comprises a shell and a refracting mirror installed inside the shell, wherein the refracting mirror is inclined at 45 degrees relative to the horizontal plane, so that light rays in the vertical direction can be injected into the incident end of the electron microscope 41 through the refracting mirror and finally horizontally; meanwhile, the lens barrel 43 is arranged in the vertical direction, the lens barrel 43 is fixedly arranged at the top of the light path conversion lens 42, the top end of the lens barrel 43 can face the transparent sample container 2 in the moving process of the microscope mechanism 4, at the moment, the lens barrel 43 plays a role in collecting light rays, and can be used for receiving the imaging light rays in the transparent sample container 2, so that the light rays are finally refracted from the lens barrel 43 to the electron microscope 41, imaging actions are realized, and the rapid data acquisition effect can be achieved by matching with an automatic focusing function and an automatic switching detection area function.
Referring to fig. 8, if the sample is sufficiently natural, the microscope mechanism 4 can directly observe the sample, and if the sample is insufficiently light, the light source mechanism 5 needs to supplement the light to improve the display definition of the detected sample.
Specifically, the light source mechanism 5 is disposed at the top plate 13 of the frame 1 and is located above the transparent sample container 2, and when performing polishing operation, the light source mechanism 5 is specifically located directly above the transparent sample container 2, and the light source mechanism 5, the transparent sample container 2 and the microscope mechanism 4 are located at the same straight line connection point, so that light can penetrate through the transparent sample container 2 and enter the microscope mechanism 4 to realize high-definition imaging.
However, since the light source mechanism 5 is located directly above the transparent sample container 2, the light source mechanism 5 may hinder the replacement of the transparent sample container 2, and a general solution is to increase the height or volume of the light source mechanism 5, however, in a conventional arrangement, there are generally the following drawbacks: on one hand, the volume or the height is increased, so that the whole size of the instrument is increased, the material cost and the die opening cost are increased, and the compactness of the structure is also influenced; on the other hand, an increase in height or an increase in volume may cause an increase in distance between the light source unit 5 and the transparent sample container 2, and light in the irradiation path of the light source unit 5 may be scattered, resulting in a large loss, and the irradiation effect may be difficult to reach an ideal state, and may have a certain influence on the development.
Based on this, in the present embodiment, the light source mechanism 5 is provided in a movable structure, and by removing the light source mechanism 5 without changing the overall height of the light source mechanism 5, the replacement of the transparent sample container 2 can be facilitated, while the illumination intensity can be maintained within a reasonable range.
Specifically, the light source mechanism 5 includes a light source portion 51 and a moving portion 52, the light source portion 51 is used to emit illumination light, the light source portion 51 is specifically an LED lamp, and other elements capable of emitting light sources may be selected and used, which is not specifically shown herein.
The light source 51 is slidably mounted on the chassis 1 by the moving unit 52 to adjust the position of the light source 51. Specifically, the moving portion 52 includes a sliding frame 521 and a sliding rail 522, the light source portion 51 is fixedly mounted on the sliding frame 521, the sliding rail 522 is fixedly mounted on the top plate 13, the sliding frame 521 is slidably mounted on the sliding rail 522, one end of the sliding rail 522 is close to the positioning hole 14, the other end extends to a position far away from the positioning hole 14, at this time, under the guiding action of the sliding rail 522, the sliding frame 521 can drive the light source portion 51 to be close to or far away from the upper side of the transparent sample container 2, so that the transparent sample container 2 is convenient to replace and polish in the switching process of the position states.
In other embodiments, the movable portion 52 may be replaced by a rotating shaft or a rotating disc structure, and the light source portion 51 may be moved closer to or farther from the transparent sample container 2 by rotating or swinging, so as to adjust the position.
The implementation principle of the sample analyzer of the embodiment of the application is as follows: compared with the manual slide glass adjustment and focal length adjustment operation in the related art, the microscopic mechanism 4 can be driven by the displacement mechanism 3 to randomly displace along the x direction, the y direction and the z direction in the three-dimensional space, on one hand, the detection area can be automatically adjusted, errors in the manual adjustment process are reduced, the time consumed in the repeated position adjustment and correction process is saved, in the process, the transparent sample container 2 can play roles in perspective observation and sample loading, on the other hand, the automatic focusing can be realized by adjusting the position of the microscopic mechanism 4, the focusing action is more automatic, and the convenience and the overall efficiency in the sample detection process are optimized and improved.
The above embodiments are not intended to limit the scope of the present application, so: all equivalent changes in structure, shape and principle of the application should be covered in the scope of protection of the application.
Claims (10)
1. A sample analyzer comprising a frame (1), characterized in that: and also comprises
The transparent sample container (2) is arranged on the rack (1) and is used for accommodating a sample to be detected;
the displacement mechanism (3) is arranged on the frame (1);
and the microscopic mechanism (4) is arranged below the displacement mechanism (3) and positioned below the transparent sample container (2), and the displacement mechanism (3) is used for driving the microscopic mechanism (4) to move in a three-dimensional space so as to enable the detection position and focal length between the microscopic mechanism (4) and the transparent sample container (2) to be adaptively adjusted.
2. A sample analyzer as claimed in claim 1, wherein: the light source mechanism (5) is arranged on the frame (1) and located above the transparent sample container (2), and the light source mechanism (5), the transparent sample container (2) and the microscopic mechanism (4) are arranged at the same straight line connecting line.
3. A sample analyzer as claimed in claim 2, wherein: the light source mechanism (5) includes a light source section (51) for diffusing irradiation light;
and a moving part (52), wherein the light source part (51) is arranged on the rack (1) in a sliding way through the moving part (52) and is used for driving the light source part (51) to be close to or far from the upper part of the transparent sample container (2).
4. A sample analyzer as claimed in claim 1, wherein: the microscopy mechanism (4) comprises
An electron microscope (41) provided in the displacement mechanism (3);
an optical path switching mirror (42) connected to the electron microscope (41);
and a lens barrel (43) connected with the light path conversion lens (42) for receiving the imaging light from the transparent sample container (2), the light path conversion lens (42) being used for refracting the imaging light from the lens barrel (43) into the electron microscope (41).
5. A sample analyzer as claimed in claim 1, wherein: the displacement mechanism (3) comprises
The first traversing assembly (31) is arranged on the frame (1) and provided with a first sliding table (311) capable of moving back and forth;
the second transverse moving assembly (32) is arranged on the first sliding table (311) and provided with a second sliding table (321) capable of moving back and forth;
and the lifting sliding component (33) is arranged on the second sliding table (321), the lifting sliding component (33) is provided with a third sliding table (331) capable of moving in a lifting manner, and the microscopic mechanism (4) is arranged on the third sliding table (331).
6. A sample analyzer as claimed in claim 5, wherein: the first traversing assembly (31) comprises
The first mounting seat (312) is arranged on the frame (1), and the first sliding table (311) is slidably arranged on the first mounting seat (312);
the first screw rod (313) is rotatably arranged on the first mounting seat (312), and the first screw rod (313) is connected with the first sliding table (311);
and a first driving source (314) provided on the first mounting base (312) and connected to the first screw (313) for driving the first screw (313) to rotate.
7. A sample analyzer as claimed in claim 5, wherein: the second traversing assembly (32) comprises
The second installation seat (322) is arranged on the first transverse moving assembly (31), and the second sliding table (321) is slidably arranged on the second installation seat (322);
the second screw rod (323) is rotatably arranged on the second installation seat (322), and the second screw rod (323) is connected with the second sliding table (321);
and a second driving source (324) arranged on the second mounting seat (322), connected with the second screw rod (323) and used for driving the second screw rod (323) to rotate.
8. A sample analyzer as claimed in claim 5, wherein: the lifting and sliding assembly (33) comprises
The third mounting seat (332) is arranged on the second transverse moving assembly (32), and the third sliding table (331) is slidably arranged on the third mounting seat (332);
the third screw rod (333) is rotatably arranged on the third mounting seat (332), and the third screw rod (333) is connected with the third sliding table (331);
and a third driving source (334) provided on the third mounting base (332), connected to the third screw (333), and configured to drive the third screw (333) to rotate.
9. A sample analyzer as claimed in claim 1, wherein: the transparent sample container (2) comprises
A transparent base (21) having a receiving cavity (211) for receiving a detection reagent;
and a transparent cover body (22) for accommodating the sample, which is connected with the transparent base (21), and is internally provided with capillary holes (221) for quantitatively retaining the sample, wherein the capillary holes (221) are communicated with the accommodating cavity (211), and the accommodating cavity (211) and the capillary holes (221) which are mutually communicated are at least two groups.
10. A sample analyzer as claimed in claim 1, wherein: the rack (1) is provided with a positioning hole (14), the hole wall of the positioning hole (14) is provided with a positioning convex part (141), the transparent sample container (2) is provided with a positioning concave part (212) which is in plug-in fit with the positioning convex part (141), and the transparent sample container (2) is placed at the positioning convex part (141) through the positioning concave part (212).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211662961.XA CN116818658B (en) | 2022-12-23 | 2022-12-23 | Sample analyzer |
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|---|---|---|---|
| CN202211662961.XA CN116818658B (en) | 2022-12-23 | 2022-12-23 | Sample analyzer |
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| CN116818658B CN116818658B (en) | 2024-02-27 |
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| CN201184883Y (en) * | 2007-07-16 | 2009-01-21 | 山东优生医疗科技有限公司 | Full-automatic blood conventional intelligent analyzer |
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| CN202710836U (en) * | 2012-07-31 | 2013-01-30 | 广州市道真生物科技有限公司 | Microscopic image automatic acquisition apparatus |
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| CN213750484U (en) * | 2020-11-30 | 2021-07-20 | 深圳市瑞图生物技术有限公司 | Microscope adjustment mechanism and sample analyzer |
| CN113358432A (en) * | 2021-05-31 | 2021-09-07 | 东南大学 | Micro-area sample collecting device for tissue slice |
| CN114136886A (en) * | 2021-11-29 | 2022-03-04 | 山东仕达思医疗科技有限公司 | Slide sample analysis system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201184883Y (en) * | 2007-07-16 | 2009-01-21 | 山东优生医疗科技有限公司 | Full-automatic blood conventional intelligent analyzer |
| CN201266175Y (en) * | 2008-08-22 | 2009-07-01 | 重庆大学 | Three-dimensional displacement micro observation device |
| CN202710836U (en) * | 2012-07-31 | 2013-01-30 | 广州市道真生物科技有限公司 | Microscopic image automatic acquisition apparatus |
| US20170031150A1 (en) * | 2015-07-31 | 2017-02-02 | Olympus Corporation | Inverted microscope and inverted microscope system |
| CN213750484U (en) * | 2020-11-30 | 2021-07-20 | 深圳市瑞图生物技术有限公司 | Microscope adjustment mechanism and sample analyzer |
| CN113358432A (en) * | 2021-05-31 | 2021-09-07 | 东南大学 | Micro-area sample collecting device for tissue slice |
| CN114136886A (en) * | 2021-11-29 | 2022-03-04 | 山东仕达思医疗科技有限公司 | Slide sample analysis system |
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| CN116818658B (en) | 2024-02-27 |
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