CN116801735A - 用于预防或治疗脑功能下降或者维持或改善脑功能的组合物 - Google Patents

用于预防或治疗脑功能下降或者维持或改善脑功能的组合物 Download PDF

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CN116801735A
CN116801735A CN202180092790.9A CN202180092790A CN116801735A CN 116801735 A CN116801735 A CN 116801735A CN 202180092790 A CN202180092790 A CN 202180092790A CN 116801735 A CN116801735 A CN 116801735A
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amino acid
acid sequence
dna
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homology
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新开省二
北村明彦
山田拓司
牛田一成
土田纱耶香
上田敦史
甲田哲之
狩屋贵洋
川原知浩
小林洋大
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Tokyo Institute of Technology NUC
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Abstract

课题在于,提供痴呆症的评价方法及用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,对健康者、轻度认知障碍者、及阿尔茨海默病患者的肠内微生物群进行比较。其结果是,筛选出作为与认知功能有关联的肠内微生物的、属于粪杆菌属的微生物等。进而,明确了具有特定DNA的普氏栖粪杆菌对学习/记忆障碍等脑功能下降发挥改善效果。

Description

用于预防或治疗脑功能下降或者维持或改善脑功能的组合物
技术领域
本发明涉及用于预防或治疗脑功能下降或者维持或改善脑功能的微生物。另外,本发明涉及上述微生物、该微生物的成分或包含该微生物的培养物的组合物、以及轻度认知障碍或阿尔茨海默病的评价方法。
背景技术
脑与脊髓一起构成中枢神经系统,于认知、运动、生命维持等神经介导的活动中发挥核心作用。因此,其功能下降会给日常生活、社会生活带来巨大障碍。尤其是随着近年来的急速老龄化,阿尔茨海默病(AD)等、进而也作为其前期阶段的轻度认知障碍(MCI)的增加已成为世界性问题,期望开发出对其预防、治疗等有效的方法。
在该现状下,近年来,脑与肠的双向信息传递(脑肠互动)受到关注,可知在肠内生息的微生物(肠内微生物、肠内细菌)不仅对其宿主的身体健康造成影响,也对脑的功能造成影响。
例如,有报告指出,在AD模型小鼠中,由抗生素给予所引起的肠内微生物群的变动对与该疾病相关的脑内炎症及淀粉样蛋白β量造成影响(非专利文献1);在不具有肠内微生物群的无菌AD模型小鼠中,与该疾病相关的脑内淀粉样蛋白β量减少(非专利文献2)。进而,在痴呆症患者与健康者之间比较肠内微生物群,结果获知在前者中拟杆菌属(Bacteroides)量变少(非专利文献3)。
另外,还获知普氏栖粪杆菌(Faecalibacterium prausnitzii)对大鼠的应激诱导性抑郁样及焦虑样行为显现出预防及治疗效果(非专利文献4)。然而,并未报道对认知功能下降的预防、治疗及症状缓解、以及认知功能的维持及改善。
现有技术文献
非专利文献
非专利文献1:Minter MR.等、Sci Rep.、2016年7月21日、6:30028.
非专利文献2:Harach T.等、Sci Rep.、2017年2月8日、7:41802.
非专利文献3:Saji N.等、Sci Rep.、2019年1月30日、9(1):1008.
非专利文献4:Hao Z.等、Psychoneuroendocrinology、2019年6月、104卷、132~142页
发明内容
发明要解决的问题
本发明发现了对脑功能下降有效的肠内微生物,提供以该微生物为有效成分的、用于预防或治疗脑功能下降或者维持或改善脑功能的组合物。另外,本发明的目的在于,提供筛选与认知功能等脑功能有关联的肠内微生物、并且以该微生物量为指标的痴呆症评价方法。
用于解决问题的方案
本发明人们为了实现上述目的,首先在轻度认知障碍(MCI)者或阿尔茨海默病(AD)患者与健康者之间比较肠内微生物群。其结果是,作为与宿主的认知功能有关联的肠内微生物,鉴定出了属于粪杆菌属(Faecalibacterium)的微生物等。
更具体而言,我们发现,属于粪杆菌属的微生物、属于瘤胃球菌科(Ruminococcaceae)的属名不明的微生物、属于厌氧棒杆菌属(Anaerostipes)的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌属(Barnesiella)的微生物及属于瘤胃球菌属(Ruminococcus)的微生物在肠内微生物群中的相对丰度方面,MCI与健康者相比低,另一方面,属于普雷沃菌属(Prevotella)的微生物的相对丰度方面,MCI与健康者相比高。
另外还发现,属于布劳特氏菌属(Blautia)的微生物、属于纺锤链杆菌属(Fusicatenibacter)的微生物、属于瘤胃球菌属的微生物、及属于真杆菌属(Eubacterium)的微生物在肠内微生物群中的相对丰度方面,AD患者与健康者相比低,另一方面,属于副拟杆菌属(Parabacteroides)的微生物的相对丰度方面,AD患者与健康者相比高。
进而,对于属于粪杆菌属的微生物(普氏栖粪杆菌)株,本发明人们从MCI者的粪便试样中成功分离培养了1株、从健康者中成功分离培养了11株。然后将它们分别给予至AD模型小鼠,使用Y迷宫试验及被动回避试验评价该小鼠的认知功能下降(学习/记忆障碍)的改善程度。其结果是,确认由Fp14(保藏编号NITE BP-03169)及Fp360(NITE BP-03196)规定的2株微生物有改善效果。
进而,对上述2株与此外的10株Fp株的全基因组序列进行比较,结果成功筛选出与序列号:1~57及422中记载的DNA序列对应的、前者所特有的28个基因(种间同源基因)。
另外,对Fp14与此外的11株的全基因组序列进行比较,结果成功筛选出与序列号:58~207记载的DNA序列对应的、前者所特有的150个种间同源基因。
进而,对Fp360与此外的11株的全基因组序列进行比较,结果成功筛选出与序列号:208~421记载的DNA序列对应的、前者所特有的214个种间同源基因。
由此发现了可对脑功能下降发挥改善效果的Fp株所特有的DNA序列(种间同源基因),至此完成了本发明。
即,本发明涉及:对于预防或治疗脑功能下降或者维持或改善脑功能有用的Fp株;该微生物的成分;该微生物的培养物;或者包含它们中的任意者作为有效成分的组合物;以及,以与宿主的认知功能有关联的肠内微生物量为指标来进行痴呆症评价的方法,更详细而言,提供以下发明。
<1>一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有下述(1)~(28)中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
(1)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(2)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:21或54记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(3)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:18或55记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(4)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:9或30记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(5)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:19或33记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(6)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:17或34记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(7)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:3或43记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(8)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:6或53记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(9)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:7或35记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(10)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:2或39记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(11)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:25或41记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(12)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:23或50记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(13)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:24或45记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(14)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:26或48记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(15)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:8或40记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(16)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:4或37记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(17)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:13或38记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(18)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:16或56记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(19)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:14或57记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(20)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:27或36记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(21)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:12或42记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(22)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:15、31或49记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(23)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:5、52或51记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(24)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:20或44记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(25)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:1或32记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(26)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:11或29记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(27)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:10或47记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(28)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:28或422记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
<2>根据<1>所述的组合物,其中,上述普氏栖粪杆菌为具有上述(1)~(28)的28种DNA的普氏栖粪杆菌。
<3>一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有下述(1)~(3)中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
(1)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(2)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:21或54记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(3)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:18或55记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
<4>根据<3>所述的组合物,其中,上述普氏栖粪杆菌为具有上述(1)~(3)所述的3种DNA的普氏栖粪杆菌。
<5>一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有选自下述DNA组中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
分别包含序列号:58~207相关的核苷酸序列的150种DNA所组成的组(其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列。N为58~207中的任意者)。
<6>一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有选自下述DNA组中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
分别包含序列号:208~421相关的核苷酸序列的214种DNA所组成的组(其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列。N为208~421中的任意者)。
<7>根据<1>~<6>中任一项所述的组合物,其中,上述脑功能为认知功能。
<8>根据<1>~<6>中任一项所述的组合物,其为食品组合物。
<9>根据<1>~<6>中任一项所述的组合物,其为药物组合物。
<10>一种由保藏编号NITE BP-03169规定的微生物。
<11>一种由保藏编号NITE BP-03196规定的微生物。
本发明另外涉及:上述普氏栖粪杆菌、上述由保藏编号NITE BP-03169规定的微生物、上述由保藏编号NITE BP-03196规定的微生物、这些微生物的成分、或这些微生物的培养物的用于制造上述组合物的应用。
本发明另外涉及:上述普氏栖粪杆菌、上述由保藏编号NITE BP-03169规定的微生物、上述由保藏编号NITE BP-03196规定的微生物、这些微生物的成分、或这些微生物的培养物的用于预防或治疗脑功能下降或者维持或改善脑功能的应用。
本发明另外涉及:用于预防或治疗脑功能下降或者维持或改善脑功能的上述普氏栖粪杆菌、上述由保藏编号NITE BP-03169规定的微生物、上述由保藏编号NITE BP-03196规定的微生物、这些微生物的成分、或这些微生物的培养物。
本发明另外涉及:一种用于预防或治疗脑功能下降或者维持或改善脑功能的方法,其对对象给予有效量的上述普氏栖粪杆菌、上述由保藏编号NITE BP-03169规定的微生物、上述由保藏编号NITE BP-03196规定的微生物、这些微生物的成分、或这些微生物的培养物。
进而,本发明涉及以与宿主的认知功能有关联的肠内微生物量为指标来进行痴呆症评价的方法,更详细而言,提供以下发明。
<12>一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述微生物为选自由属于粪杆菌属的微生物、属于厌氧棒杆菌属的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌属的微生物、及属于瘤胃球菌属的微生物组成的组中的至少1种微生物。
<13>一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述微生物为选自由属于普雷沃菌属的微生物组成的组中的至少1种微生物。
<14>一种阿尔茨海默病的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者罹患了阿尔茨海默病的工序,并且上述微生物为选自由属于布劳特氏菌属的微生物、属于纺锤链杆菌属的微生物、属于瘤胃球菌属的微生物、及属于真杆菌属的微生物组成的组中的至少1种微生物。
<15>一种阿尔茨海默病的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者罹患了阿尔茨海默病的工序,并且上述微生物为选自由属于副拟杆菌属的微生物组成的组中的至少1种微生物。
<16>一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的DNA进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述DNA进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述DNA为下述(a)~(i)中的至少1种DNA,
(a)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(b)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:158记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(c)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:204记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(d)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:205记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(e)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:206记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(f)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:365记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(g)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:414记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(h)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:420记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(i)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:421记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
<17>一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的DNA进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述DNA进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述DNA为包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:297记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
发明的效果
根据本发明,通过给予具有特定DNA序列的普氏栖粪杆菌株,能够预防或治疗对象的脑功能下降、尤其是认知功能下降。进而,还能够维持或改善对象的脑功能、尤其是认知功能。
另外,根据本发明,能够以肠内微生物量为指标来进行痴呆症、轻度认知障碍、或其前期阶段的诊断。特别地,本发明中对其丰度分别与轻度认知障碍及阿尔茨海默病相关的肠内微生物进行了鉴定,这些肠内微生物成为痴呆症诊断的有效指标。
附图说明
图1为示出在健康者和轻度认知障碍(MCI)者之间比较肠内微生物群的结果的火山图。图中,X轴表示利用log2对相对于健康者的各肠内微生物的丰度(abundance)的中央值的、MCI者的该值的比进行转换而得的值,Y轴表示利用-log10对通过Wilcoxon秩和检验计算出的P值进行转换而得的值。另外,图中的圆的尺寸表示各肠内微生物的丰度的中央值。
图2为示出在健康者和阿尔茨海默病(AD)患者之间比较肠内微生物群的结果的火山图。关于图中的符号,除了将“MCI者”替换为“AD患者”以外与图1相同。
图3为示出对向脑室内给予了淀粉样蛋白β的小鼠短期(11天)经口给予各普氏栖粪杆菌(Fp)株(均为活菌),并使用Y迷宫试验评价该小鼠的学习记忆障碍的改善程度的结果的图。图中,横轴表示给予的各Fp株及对照物质等,纵轴表示自主交替行动率(Alteration rate)。各数据表示平均值+标准误差(SEM)。“**”表示学生t检验的结果,表示与对照组1(假手术)相比P<0.01。“#”及“##”表示学生t检验的结果,分别表示与对照组3(给予培养用培养基)相比P<0.05及P<0.01。(双剑形符号)表示学生t检验的结果,表示与对照组2(给予生理盐水)相比P<0.01。
图4为示出对向脑室内给予淀粉样蛋白β的小鼠短期(11天)经口给予各Fp株(均为活菌),并使用被动回避试验评价该小鼠的学习记忆障碍的改善程度的结果的图。图中,横轴表示给予的各Fp株及对照物质等,纵轴表示反应潜伏时间(Latency time)。各数据表示平均值+标准误差(SEM)。“**”表示学生t检验的结果,表示与对照组1(假手术)相比P<0.01。“#”表示学生t检验的结果,表示与对照组3(给予培养用培养基)相比P<0.05。(双箭符号)表示学生t检验的结果,表示与对照组2(给予生理盐水)相比P<0.01。
图5为示出对向脑室内给予淀粉样蛋白β的小鼠短期(11天)经口给予各Fp株,并使用Y迷宫试验评价该小鼠的学习记忆障碍的改善程度的结果的图。图中,“活菌”、“死菌体”及“上清”表示分别给予各菌株的活菌、死菌体及培养上清的结果。其它图中的符号也与图3同样。
图6为示出对向脑室内给予淀粉样蛋白β的小鼠短期(11天)经口给予各Fp株,并使用被动回避试验评价该小鼠的学习记忆障碍的改善程度的结果的图。图中,“live”、“pasteurized”及“sup”表示分别给予各菌株的活菌、死菌体及培养上清的结果。其它图中的符号也与图4同样。
图7为示出为了在Fp株之间进行全基因组的比较分析而使用的管线的概要的图。
图8为示出3个种间同源基因(OG0003538、OG0003537及OG0003536)为表征Fp14及Fp360的独特基因、这些在基因组上相邻地配置的概略图。图中,“2238”、“2237”及“2236”分别对应于序列表及表2记载的“ICBIDGAJ_02238(序列号:18)”、“ICBIDGAJ_02237(序列号:21)”及“ICBIDGAJ_02236(序列号:22)”。“2132”、“2133”及“2134”分别对应于序列表及表2记载的“BLCPAMOF_02132(序列号:55)”、“BLCPAMOF_02133(序列号:54)”及“BLCPAMOF_02134(序列号:46)”。“2236”及“2134”上所带有的“*”表示:Wilcoxon秩和检验的结果是,MCI组的这些种间同源基因的相对丰度与健康者组相比显著低(P<0.05)。
图9为示出表征Fp14的独特的12个基因在基因组上相邻地配置的概略图。“778”、“768”及“767”为分别对应于序列表记载的“ICBIDGAJ_00778(序列号:162)”、“ICBIDGAJ_00768(序列号:198)”及“ICBIDGAJ_00767(序列号:203)”的推测为胞外蛋白的种间同源基因。“777”~“769”为分别对应于序列表记载的“ICBIDGAJ_00777(序列号:192)”、“ICBIDGAJ_00776(序列号:191)”、“ICBIDGAJ_00775(序列号:190)”、“ICBIDGAJ_00774(序列号:189)”、“ICBIDGAJ_00773(序列号:188)”、“ICBIDGAJ_00772(序列号:187)”、“ICBIDGAJ_00771(序列号:186)”、“ICBIDGAJ_00770(序列号:185)”及“ICBIDGAJ_00769(序列号:59)”的推测为跨膜蛋白的种间同源基因。需要说明的是,图中位于825000附近的不带编号的涂黑2个种间同源基因均是推测为胞外蛋白的非Fp14特有的种间同源基因。
图10为示出表征Fp14的独特的5个基因在基因组上相邻地配置的概略图。图中,“757”及“756”分别对应于序列表记载的“ICBIDGAJ_00757(序列号:159)”及“ICBIDGAJ_00756(序列号:158)”。作为海藻糖相关KO的“755”、“754”及“753”对应于序列表记载的“ICBIDGAJ_00755(序列号:205)”、“ICBIDGAJ_00754(序列号:204)”及“ICBIDGAJ_00753(序列号:206)”。需要说明的是,“757”是推测为胞内蛋白的种间同源基因,“756”、“755”及“753”分别是推测为胞外蛋白的种间同源基因,“754”是推测为跨膜蛋白的种间同源基因。其它涂黑的种间同源基因均为非Fp14特有的种间同源基因。“750”~“756”上所带有的“*”表示:Wilcoxon秩和检验的结果是,MCI组的这些种间同源基因的相对丰度与健康者组相比显著低(P<0.05)。
图11为示出长期(13个月)经口给予Fp14的AD模型小鼠的脑组织中的老年斑占有率(%)的图。图中,横轴表示经口给予的物质,另外“C&H”、“C”及“H”分别表示“大脑皮质及海马体”、“大脑皮质”、以及“海马体”的分析结果。各数据表示平均值+标准误差(SEM)。图中所附的P值通过学生t检验而算出。
具体实施方式
(普氏栖粪杆菌)
如后述的实施例所示,本发明人们已经明确,通过给予具有后述的本发明相关DNA中的至少1种DNA的普氏栖粪杆菌株,可改善对象的脑功能下降。因此,本发明涉及具有特定DNA序列的普氏栖粪杆菌。
“普氏栖粪杆菌(Faecalibacterium prausnitzii)”通常是指属于厚壁菌门(Firmicutes)梭菌纲(Clostridia)真细菌目(Eubacteriales)颤螺菌科(Oscillospiraceae)粪杆菌属(Faecalibacterium)的厌氧性且革兰氏阴性的杆菌。该微生物(细菌)具有不形成芽孢、且由乙酸生成丁酸的特征。进而,普氏栖粪杆菌例如也可包含如下微生物:将形态特征(例如菌落形状、细胞形状等)、生理、生物化学性状(例如糖的同化性、生长温度、最适pH值等)、化学分类学性状(菌体脂肪酸组成等)等性状与已知的普氏栖粪杆菌进行比较,并基于其性状的1个比较结果鉴定为相同或实质上相同的微生物。另外,也可包含基于16SrRNA基因的核苷酸序列分析而鉴定为相同或实质上相同的微生物。
更具体而言,已知的普氏栖粪杆菌与鉴定为相同或实质上相同的微生物为同属的微生物,16SrRNA基因的碱基序列与已知的普氏栖粪杆菌中的任意种微生物的16SrRNA基因的碱基序列具有97%以上、优选为98%以上、更优选为99%以上、更优选为100%的同源性,且优选与已知的普氏栖粪杆菌中的任意种微生物具有任意种相同的微生物学性质(菌学性质)。
进而,只要不损害本发明的效果,则也可为由已知的普氏栖粪杆菌的各微生物通过变异处理、基因重组、自然变异株的选择等进行育种而成的微生物。该“变异株”包括:本领域技术人员对特定微生物(菌株)通过本领域技术人员熟知的方法在不会使其性质产生变化的范围内使其变异而成者;通过自然变异株的选择等进行育种而成者;或本领域技术人员可确认与其同等者。
另外,已知的普氏栖粪杆菌并不限定于以该菌株名于规定机构进行保藏或登录的株本身(以下,也称为“保藏株”),也包含与其实质上同等的株(也称为“衍生株”或“诱导株”)。
关于菌株,“与保藏株实质上同等的株”是指与保藏株属于相同种,且能够发挥出本发明效果的株。与保藏株实质上同等的株例如可为以该保藏株为母株的衍生株。作为衍生株,可例举由保藏株进行育种而成的株或由保藏株自然产生的株。
实质上相同的菌株、衍生株可列举如下所述的株。
(1)通过RAPD法(Randomly Amplified Polymorphic DNA,随机扩增多态性DNA)、PFGE法(Pulsed-field gel electrophoresis,脉冲场凝胶电泳)判定为相同的菌株的菌株(记载于Probiotics in food/Health and nutritional properties and guidelinesfor evaluation 85Page43)
(2)仅保有来自该保藏菌株的基因,不具有来自外源的基因,且DNA的同源性为97%以上(优选为98%以上)的菌株
(3)由该菌株进行育种而成的株(包含基因工程学改变、突变、自发突变)、具有相同性状的株。
“本发明的普氏栖粪杆菌”是上述通常的普氏栖粪杆菌中,具有下述本发明的DNA组中的至少1种DNA的微生物。
如下述实施例所示,作为与已确认对于脑功能下降有改善效果的Fp14及Fp360所特有的28种种间同源基因相对应的序列,提取序列号:1~57及422记载的DNA序列。因此,作为本发明的DNA组,可列举由下述(1)~(28)记载的DNA组成的组。
(1)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(2)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:21或54记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(3)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:18或55记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(4)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:9或30记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(5)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:19或33记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(6)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:17或34记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(7)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:3或43记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(8)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:6或53记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(9)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:7或35记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(10)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:2或39记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(11)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:25或41记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(12)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:23或50记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(13)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:24或45记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(14)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:26或48记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(15)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:8或40记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(16)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:4或37记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(17)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:13或38记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(18)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:16或56记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(19)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:14或57记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(20)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:27或36记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(21)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:12或42记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(22)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:15、31或49记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(23)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:5、52或51记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(24)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:20或44记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(25)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:1或32记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(26)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:11或29记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(27)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:10或47记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(28)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:28或422记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
在上述(1)~(28)记载的DNA中,本发明的普氏栖粪杆菌为具有优选2种以上(例如3种以上、4种以上)、更优选5种以上(例如6种以上、7种以上、8种以上、9种以上)、进一步优选10种以上(例如11种以上、12种以上、13种以上、14种以上)、更优选15种以上(例如16种以上、17种以上、18种以上、19种以上)、进一步优选20种以上(例如21种以上、22种以上、23种以上、24种以上)、更优选25种以上(例如26种以上、27种以上)、特别优选28种DNA的微生物(即,具有上述(1)~(28)记载的28种DNA的普氏栖粪杆菌)。
本发明的普氏栖粪杆菌另外优选为具有上述(1)~(3)中的至少1种DNA的微生物,更优选为具有上述(1)~(3)中的至少2种DNA的微生物,进一步优选为具有上述(1)~(3)记载的3种DNA的微生物。
进而,另外本发明的普氏栖粪杆菌优选为至少具有上述(1)记载的DNA的微生物。
另外,本发明的普氏栖粪杆菌可以除了包含上述(1)~(28)中的至少1种DNA、上述(1)~(3)中的至少1种DNA、或上述(1)记载的DNA以外还包含选自后述的分别包含序列号:58~207相关的核苷酸序列的150种DNA组和/或分别包含序列号:208~421相关的核苷酸序列的214种DNA组中的至少1种DNA。
如后述的实施例所示,作为与仅确认对脑功能下降有改善效果的Fp14所特有的150种种间同源基因相对应的序列,提取序列号:58~207记载的DNA序列。因此,作为本发明的DNA组,可列举下述DNA组。
分别包含序列号:58~207相关的核苷酸序列的150种DNA组(其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列。这里的“N”为58~207中的任意者)。
上述分别包含序列号:58~207相关的核苷酸序列的150种DNA组中,本发明的普氏栖粪杆菌为具有优选2种以上(例如3种以上、4种以上)、更优选5种以上(例如6种以上、7种以上、8种以上、9种以上)、进一步优选10种以上、更优选20种以上、进一步优选30种以上、更优选40种以上、进一步优选50种以上、更优选60种以上、进一步优选70种以上、更优选80种以上、进一步优选90种以上、更优选100种以上、进一步优选110种以上、更优选120种以上、进一步优选130种以上、更优选140种以上(例如141种以上、142种以上、143种以上、144种以上、145种以上、146种以上、147种以上、148种以上、149种以上)、特别优选150种DNA的微生物。
本发明的普氏栖粪杆菌另外为具有选自分别包含序列号:158及204~206相关的核苷酸序列的4种DNA组成的组中的至少1种DNA、优选具有2种以上DNA、更优选具有3种以上DNA、进一步优选具有4种DNA的微生物。
另外,本发明的普氏栖粪杆菌可以除了包含选自分别包含序列号:58~207相关的核苷酸序列的150种DNA组或分别包含序列号:158及204~206相关的核苷酸序列的4种DNA组中的至少1种DNA以外,还包含上述(1)~(28)中的至少1种DNA、上述(1)~(3)中的至少1种DNA、或上述(1)记载的DNA。
如后述的实施例所示,作为与仅确认对脑功能下降有改善效果的Fp360所特有的214种种间同源基因相对应的序列,提取序列号:208~421记载的DNA序列。因此,作为本发明的DNA组,可列举下述DNA组。
分别包含序列号:208~421相关的核苷酸序列的214种DNA组(其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列。这里的“N”为208~421中的任意者)。
上述分别包含序列号:208~421相关的核苷酸序列的214种DNA组中,本发明的普氏栖粪杆菌为具有优选2种以上(例如3种以上、4种以上)、更优选5种以上(例如6种以上、7种以上、8种以上、9种以上)、进一步优选10种以上、更优选20种以上、进一步优选30种以上、更优选40种以上、进一步优选50种以上、更优选60种以上、进一步优选70种以上、更优选80种以上、进一步优选90种以上、更优选100种以上、进一步优选110种以上、更优选120种以上、进一步优选130种以上、更优选140种以上、进一步优选150种以上、更优选160种以上、进一步优选170种以上、更优选180种以上、进一步优选190种以上、更优选200种以上(例如201种以上、202种以上、203种以上、204种以上)、进一步优选205种以上(例如206种以上、207种以上、208种以上、209种以上)、更优选210种以上(例如211种以上、212种以上、213种以上)、特别优选214种DNA的微生物。
本发明的普氏栖粪杆菌另外为具有选自分别包含序列号:365、414、420及421相关的核苷酸序列的4种DNA组成的组中的至少1种DNA、优选具有2种以上DNA、更优选具有3种以上DNA、进一步优选具有4种DNA的微生物。
另外,本发明的普氏栖粪杆菌可以除了包含选自分别包含序列号:208~421相关的核苷酸序列的214种DNA组成的组或分别包含序列号:365、414、420及421相关的核苷酸序列的4种DNA组中的至少1种DNA以外,还包含上述(1)~(28)中的至少1种DNA、上述(1)~(3)中的至少1种DNA、或上述(1)记载的DNA。
需要说明的是,本发明中,本发明的DNA也可采用如下DNA的形态:除了包含编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列的核苷酸序列以外,还包含编码在序列号:N记载的核苷酸序列所编码的氨基酸序列中置换、缺失、添加、和/或插入了1个或多个氨基酸的氨基酸序列的核苷酸序列的DNA;或与由序列号:N记载的核苷酸序列构成的DNA在严格条件下杂交的DNA(这里的N为1~422中的至少1个编号)。
“同源性”可以是指类似性(similarity)或同一性(identity)。另外,“同源性”尤其可以是指同一性(identity)。氨基酸序列的同源性可利用BLAST(Basic LocalAlignment Search Tool at the National Center for Biological Information(美国国立生物学信息中心的基本局域比对检索工具))等比对程序而确定。例如,氨基酸序列的同源性可列举使用blastp算出的氨基酸序列间的同源性,更具体而言,可列举对blastp使用默认参数(即,使用初始设定的参数)算出的氨基酸序列间的同源性。
本发明相关的氨基酸序列的“同源性”为40%以上,优选为50%以上、更优选为60%以上、进一步优选为70%以上、更优选为80%以上、进一步优选为85%以上(例如86%以上、87%以上、88%以上、89%以上)、更优选为90%以上(例如91%以上、92%以上、93%以上、94%以上)、进一步优选为95%以上(例如96%以上、97%以上、98%以上、99%以上)、特别优选为100%。
本发明中,作为被置换等的氨基酸数,只要包含以各序列号记载的核苷酸序列所编码的氨基酸序列的多肽不因该置换等而损害其功能、活性就没有特别限定,例如为1000个氨基酸以内(更具体地,900个氨基酸以内、800个氨基酸以内、700个氨基酸以内、600个氨基酸以内)、500个氨基酸以内(更具体地,400个氨基酸以内、300个氨基酸以内、200个氨基酸以内)、100个氨基酸以内(更具体地,90个氨基酸以内、80个氨基酸以内、70个氨基酸以内、60个氨基酸以内)、50个氨基酸以内(更具体地,40个氨基酸以内、30个氨基酸以内、20个氨基酸以内)、10个氨基酸以内(更具体地,9个氨基酸以内、8个氨基酸以内、7个氨基酸以内、6个氨基酸以内、5个氨基酸以内、4个氨基酸以内、3个氨基酸以内、2个氨基酸以内、1个氨基酸)。
氨基酸的置换等优选为保守性置换。“保守性置换”是指被具有化学上同样的侧链的其它氨基酸残基置换。具有化学上同样的氨基酸侧链的氨基酸残基的组在本发明所属的技术领域中是众所熟知的。例如,在酸性氨基酸(天冬氨酸、谷氨酸)、碱性氨基酸(赖氨酸、精氨酸、组氨酸)、中性氨基酸中,可以以具有烃链的氨基酸(甘氨酸、丙氨酸、缬氨酸、亮氨酸、异亮氨酸、脯氨酸)、具有羟基的氨基酸(丝氨酸、苏氨酸)、包含硫的氨基酸(半胱氨酸、甲硫氨酸)、具有酰胺基的氨基酸(天冬酰胺、谷氨酰胺)、具有亚胺基的氨基酸(脯氨酸)、具有芳香族基团的氨基酸(苯丙氨酸、酪氨酸、色氨酸)来分类。
作为“严格条件”,例如为“1×SSC、0.1% SDS、37℃”左右的杂交条件,作为更严格的条件,为“0.5×SSC、0.1% SDS、42℃”左右的杂交条件,作为进而严格的条件,可列举“0.2×SSC、0.1% SDS、65℃”左右的杂交条件。
本领域技术人员可基于公知的方法适当制备本发明的普氏栖粪杆菌。例如可通过如下方法制备:如下述实施例所示,于厌氧性条件下,对人、非人哺乳动物(例如猪及牛等偶蹄类、鼠等啮齿类)、家禽、蟑螂等的消化道内容物(粪便等)利用公知的培养基(例如YCFA培养基、EG培养基、LYBHI培养基)进行培养,从而制备。
另外,如下述实施例中所示,Fp14及Fp360为本发明的普氏栖粪杆菌的特别优选的方式,Fp14于2020年3月6日保藏于独立行政法人制品评价技术基盘机构专利微生物保藏中心(NITE、现在的国家技术评估学会,专利微生物保藏中心、邮编292-0818日本千叶县木更津市上总镰足2-5-8 122号室)(识别标识:Fp_0014、保藏编号:NITE BP-03169)。Fp360于2020年4月7日保藏于独立行政法人制品评价技术基盘机构专利微生物保藏中心(现在的国家技术评估学会,专利微生物保藏中心、识别标识:Fp_0360、保藏编号:NITE BP-03196)。因此,这些菌株可通过向上述保藏中心申请而获取。
需要说明的是,如上所述,本发明的普氏栖粪杆菌也可包含鉴定为与Fp14和/或Fp360相同或实质上相同的微生物,即,只要不损害本发明的效果,则不限定为由上述保藏编号规定的各保藏株,也可包含其变异株、衍生株、诱导株。更具体而言,可列举如下微生物:其与Fp14及Fp360同属,且16SrRNA基因的碱基序列与Fp14和/或Fp360的16SrRNA基因的碱基序列具有97%以上、优选为98%以上、更优选为99%以上、更优选为100%的同源性,且优选与这些微生物中的任意种具有任意种相同的微生物学性质(菌学性质)。
另外,同样地,本发明中,也可为具有上述本发明的DNA组中的至少1种DNA的普氏栖粪杆菌的变异株、衍生株、诱导株。
另外,本发明的普氏栖粪杆菌对脑功能下降具有治疗及预防效果,进而具有脑功能的维持作用及改善作用。该微生物是否具有该效果或作用例如可如下述实施例所示,通过使用脑功能已下降的非人动物的行为试验进行评价。更具体而言,当对脑功能已下降的非人动物(例如阿尔茨海默病模型动物)给予上述微生物,与未给予其的情形相比,确认到脑功能的改善的情形时,可判断上述微生物具有上述效果及作用。需要说明的是,本领域技术人员可根据欲评价的脑功能选择公知的行为试验来进行脑功能的评价。
本发明的普氏栖粪杆菌优选为具有抑制脑内的淀粉样蛋白β的堆积的作用。本发明的“淀粉样蛋白β”为如下的肽,其包含由作为膜蛋白的淀粉样蛋白β前体蛋白(APP)利用β分泌酶及γ分泌酶进行切断所产生的36~43个氨基酸。优选为包含42个氨基酸的肽(淀粉样蛋白β42)、包含40个氨基酸的肽(淀粉样蛋白β40),更优选为淀粉样蛋白β42。另外,作为堆积的淀粉样蛋白β的形态,没有特别限定,可为单体,可形成低聚物(淀粉样蛋白β低聚物),可进行纤维化(淀粉样蛋白纤维),或者也可为混合有这些者。
认为淀粉样蛋白β与阿尔茨海默病的发病、发展相关,故具有抑制其堆积的作用的普氏栖粪杆菌可发挥出对于该疾病的优异的预防等效果。该微生物是否具有该作用例如可如下述实施例所示,通过使用阿尔茨海默病模型动物的试验进行评价。更具体而言,当对阿尔茨海默病模型动物给予上述微生物,与未给予其的情形相比,脑内的淀粉样蛋白β量减少时,可判断上述微生物具有抑制脑内的淀粉样蛋白β的堆积的作用。
<用于预防或治疗脑功能下降或者维持或改善脑功能的组合物>
如后述的实施例所示,通过给予上述本发明的普氏栖粪杆菌,可抑制对象的脑功能的下降。因此,本发明提供含有本发明的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分的、用于对对象预防或治疗脑功能下降或者维持或改善脑功能的组合物。
作为于本发明的组合物中作为有效成分含有的普氏栖粪杆菌,如上所述,可为活菌,也可为死菌体,也可为活菌及死菌体这两者。作为“死菌体”,例如可列举:加热处理体、焙烧处理体、蒸煮处理体、放射线(γ射线等)照射处理体、酶处理体、药物(抗生素等)处理体、化学物质(福尔马林等)处理体、超声波处理体。另外,普氏栖粪杆菌的形态并无特别限定,可为液体或固体的任一种,但从制造时或保管时容易处理的观点出发,该形态较适宜为干燥形态(例如菌末状等)。干燥物可通过如下方法制备:使菌体分散于溶剂(水等)中,并使所得的悬浮液干燥。干燥方法没有特别限定,例如可列举喷雾干燥(spray dry)法、冷冻干燥法。灭菌方法没有特别限定,可列举:蒸煮灭菌法、UHT(Ultra Heat Treated,超高温处理)灭菌法、空气灭菌法、加压灭菌法、高压蒸气灭菌法、干热灭菌法、流通蒸气消毒法、电磁波灭菌法、电子束灭菌法、高频灭菌法、放射线灭菌法、紫外线灭菌法、环氧乙烷气体灭菌法、过氧化氢等离子体灭菌法、化学灭菌法(酒精灭菌法、福尔马林固定法、电解水处理法)等。另外,也可视情形,于利用加热等的灭菌处理的前后,或于干燥处理的前后,进行表面活性剂处理、磨碎、粉碎处理、酶处理、分级处理等,通过这些处理所获得者也可包含于本发明的组合物中。
于本发明的组合物中作为有效成分含有的普氏栖粪杆菌不仅可为上述菌体,也可为该微生物的构成物质,即微生物本身的成分(所谓菌体成分。例如,构成该微生物的氨基酸、肽、核酸、糖、脂质、维生素、激素、及这些的复合体,进而这些与磷、硫金属元素的复合体等)。
另外,本发明的组合物所含的有效成分也可为本发明的普氏栖粪杆菌的培养物。培养物可为包含该微生物者(包含增殖后的该微生物的培养液、固体培养基等),该培养物的形态并无特别限定,可为液体或固体的任一种,但从制造时或保管时容易处理的观点出发,该形态较适宜为干燥形态(例如培养干燥物等)。需要说明的是,该培养干燥物等也可由本领域技术人员使用上述干燥方法适当制备。
本发明的组合物可为药物组合物(药品、准药品等)、食品组合物(饮食品、动物用饲料等)、或模型动物实验等中所使用的试剂的形态。
本发明中的组合物可根据作为有效成分的普氏栖粪杆菌的形态(例如活菌、死菌体、菌体成分),通过公知的制剂学方法进行制剂化。例如可制成胶囊剂、片剂、丸剂、液剂、散剂、颗粒剂、细粒剂、膜衣剂、小粒剂、含片剂、舌下剂、咀嚼剂、舌下含片剂、膏剂、糖浆剂、悬浮剂、酏剂、乳剂、包衣剂、软膏剂、硬膏剂、敷剂、经皮吸收型制剂、洗剂、吸入剂、气雾剂、注射剂、栓剂等,以经口或非经口方式使用。本发明可如下述实施例中所示,通过经口非侵入性且简便地摄取。即,本发明的组合物的优选的摄取方法为经口的摄取。
于这些制剂化中,可与药理学上或作为饮食品所允许的载体、具体而言生理盐水、灭菌水、培养基、植物油、溶剂、赋形剂、基剂、乳化剂、悬浮剂、表面活性剂、稳定剂、香味剂、芳香剂、媒介剂、防腐剂、黏合剂、稀释剂、等渗剂、镇痛剂、增量剂、崩解剂、缓冲剂、包衣剂、润滑剂、着色剂、甜味剂、黏稠剂、矫味矫臭剂、助溶剂或其它添加剂等适当组合。
使用本发明的组合物作为药物组合物时,也可与用于改善脑功能下降等的公知物质组合使用。作为该公知的物质,例如可列举痴呆症药,更具体而言,为胆碱酯酶抑制剂(多奈哌齐等)、乙酰胆碱酯酶抑制剂(加兰他敏等)、谷氨酸NMDA受体抑制剂(美金刚等)、用于抑制淀粉样蛋白β的产生的药剂(γ分泌酶调节物(GSM)、γ分泌酶抑制剂(GSI)、非甾体抗炎药等)、用于抑制淀粉样蛋白β的凝聚的药剂(姜黄素、多硫酸化合物、氯碘羟喹等)、用于抑制tau的凝聚的药剂(氨基噻吩并哒嗪、花青色素、亚甲蓝等)、神经保护药(迪姆朋(Dimebon)等)。
使用本发明的组合物作为食品组合物时,例如可为健康食品、功能性食品、特定保健用食品、营养功能食品、功能性标示食品、营养辅助食品、病人用食品、或动物用饲料。需要说明的是,功能性食品通常基于其作用机制,被分类为益生菌、生物源(biogenics)、益生元、合生元这4种,本发明中可采用益生菌、生物源、合生元、益生元的形态。
本发明的饮食品除了能够以如上所述的组合物的形式摄取以外,也能够以各种饮食品的形式摄取。作为饮食品的具体例,可列举:功能性饮料、饮剂、果冻状饮料、碳酸饮料、乳饮料、茶饮料、酒精饮料、汤类等液状食品;酸奶、饮用酸奶等发酵食品、发酵饮料;食用油、调味酱、蛋黄酱、人造奶油等包含油分的制品;饭类、面类、面包类等含碳水化合物食品;火腿、香肠等畜产加工食品;日式鱼糕、鱼贝干货、腌制食品等水产加工食品;腌菜等蔬菜加工食品;果冻等半固体状食品;味噌等发酵食品;西式点心类、日式点心类、糖果类、口香糖类、软糖、冷冻甜点、冰淇淋等各种点心类;咖喱、浇汁菜、中式汤等蒸煮制品;速食汤、速食味噌汁等速食食品或微波食品等。进而也可列举制备为粉末、颗粒、片剂、胶囊剂、液状、糊状或果冻状的健康饮食品。需要说明的是,本发明中的饮食品的制造可通过该技术领域中公知的制造技术实施。于该饮食品中,也可添加对改善脑功能下降等有效的1种或2种以上成分(例如其它肠内微生物、对普氏栖粪杆菌于肠道等中的增殖有效的成分)。另外,也可通过与发挥该改善等以外的功能的其它成分或其它功能性食品组合,制成多功能性饮食品。
需要说明的是,作为上述“其它肠内微生物”,没有特别限制,可列举后述的属于粪杆菌属的微生物、属于瘤胃球菌科的属名不明的微生物、属于厌氧棒杆菌属的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌属的微生物、属于瘤胃球菌属的微生物、属于布劳特氏菌属的微生物、属于真杆菌属的微生物、属于纺锤链杆菌属的微生物、属于拟杆菌属的微生物、属于双歧杆菌属的微生物。作为上述“对普氏栖粪杆菌于肠道等中的增殖有效的成分”,可列举例如寡糖类、食物纤维类等益生元成分、可可、大麦、纤细裸藻(Euglena gracilis)。
另外,本发明中所提出的饮食品组合物也能够作为标示出保健用途的饮食品提供、销售。“标示”行为包含对需要者告知上述用途的所有行为,可为将可直接识别上述用途的表述、或如可使其想起、类推上述用途的表述附于组合物本身者,也可为附于组合物所装入的容器、包装材料或说明书者。另外,“标示”也可为作为本发明组合物的相关信息,通过传单、说明书、流行音乐、目录、海报、书籍、DVD等存储介质、电子公告板或因特网等的广告等标示、宣传本发明的组合物有效者。
<脑功能下降的预防方法等>
另外,本发明也提供一种预防、治疗、或改善对象的脑功能下降的方法,其特征在于,对对象给予或使对象摄取包含本发明的普氏栖粪杆菌、该微生物的成分、该微生物的培养物、或这些中的任一种作为有效成分的组合物(上述本发明的组合物)。
本发明中,“脑功能”是指包括判断、感觉、计算、记忆、理解、学习、思考、语言等通过脑内的信息处理实现的功能(认知功能)的脑的高级功能。“脑功能下降”例如可列举:轻度认知障碍(MCI)、学习记忆能力的下降、判断能力的下降、思考能力的下降、感觉能力的下降、计算能力的下降、语言能力的下降、集中力的下降、或由这些引起的生产性下降(其中,抑郁状态、焦虑状态除外)。另外,“脑功能下降”也包含伴有其的中枢神经疾病。作为该疾病,例如可列举痴呆症,更具体而言,可列举:阿尔茨海默病(阿兹海默型痴呆症)、路易体痴呆、帕金森氏症中的痴呆症及额颞叶型痴呆等变性性痴呆;多发性脑梗塞型痴呆症、局限性脑梗塞型痴呆症及遗传性血管性痴呆症等血管性痴呆症;早发性痴呆症;由外伤性脑损伤、物质/药品的使用、HIV感染、朊病毒病(prion disease)、或亨廷顿舞蹈症等导致的痴呆症。
本发明中,“预防”包含脑功能下降的抑制、延迟、及抑制其复发。“治疗”包含从脑功能下降完全恢复。“维持”包含无论是否罹患上述疾病均维持脑功能。“改善”包含缓解或提高与脑功能相关的症状/抑制其发展、以及抑制其复发。
本发明中的脑功能下降的预防等的“对象”为包含人类的动物。作为人以外的动物,没有特别限定,可将各种家畜、家禽、宠物、实验用动物等作为对象。具体而言,可列举:猪、牛、马、绵羊、山羊、鸡、野鸭、鸵鸟、家鸭、狗、猫、兔、仓鼠、小鼠、大鼠、猴等,但并不限于这些。另外,本发明的对象可为痴呆症等的罹患者,可列举:无需诊断为痴呆症等,例如感觉到脑功能下降者;家族中有或曾有痴呆症罹患者者;高龄者;欲改善记忆学习能力者。另外,即便对脑功能无特别的焦虑等,也可为了脑功能下降的预防、脑功能的改善、痴呆症预防等而日常摄取。
另外,本技术可为治疗性目的用途,也可为非治疗目的用途。“非治疗性用途”为不含医疗行为、即利用治疗对人体进行处置的行为的概念。例如可列举健康增进、生活习惯病预防等(例如临界区的后备军等)。
给予或摄取包含本发明的普氏栖粪杆菌、该微生物的成分、该微生物的培养物、或这些中的任一种作为有效成分的组合物(上述本发明的组合物)时,其给予量或摄取量可根据对象的年龄、体重、上述障碍的症状、健康状态、组合物的种类(药品、饮食品等)、有效成分的形态(例如活菌、死菌体、菌体成分)等适当选择。
本发明的属于粪杆菌属的微生物(活菌或死菌体)的含量或使用量并无特别限定,在上述组合物中为1×102~1×1012,更优选为1×103~1×1011,进而优选为1×104~1×1010。需要说明的是,单位为CFU/g或CFU/mL、或细胞数(个)/g或细胞数(个)/mL。CFU表示菌落形成单位(Colony forming unit)。
另外,本发明的属于粪杆菌属的微生物(活菌或死菌体)的每1天的给予量并无特别限定,优选为每1天1×103~1×1014,也可为1×104~1×1013、进而1×105~1×1013、1×106~1×1012。需要说明的是,单位为CFU/天、或细胞数(个)/天。
另外,该数值范围的上限值及下限值的组合仅为例示,这些的组合能够适当变更。另外,有效成分为微生物的成分(菌体成分)时,例如可设为与上述菌体量相对应的菌体成分量。
需要说明的是,作为包含本发明的普氏栖粪杆菌、该微生物的成分、该微生物的培养物、或这些中的任一种作为有效成分的组合物(上述本发明的组合物)的给予或摄取量,如上所述,但可每1天1次或分成多次(例如2次、3次)给予或摄取。另外,给予或摄取的期间也可根据脑功能改善程度中止,但从预防复发的观点出发,也可不中止而持续给予或摄取。需要说明的是,关于“持续”,可为每天持续,也可为隔开间隔的持续,但从效果方面出发,优选为每天持续给予或摄取普氏栖粪杆菌或包含其作为有效成分的组合物。
<用于抑制淀粉样蛋白β的堆积的组合物等>
如下述实施例所示,通过本发明,可抑制淀粉样蛋白β于脑内堆积。因此,本发明也提供以下的组合物或方法。需要说明的是,“淀粉样蛋白β”及“堆积的淀粉样蛋白β的形态”如上所述。
含有本发明的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,且用于抑制对象脑内的淀粉样蛋白β堆积的组合物。
抑制对象脑内的淀粉样蛋白β的堆积的方法的特征在于,对对象给予或使对象摄取包含本发明的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物、或这些中的任一种作为有效成分的组合物(上述组合物)。
<轻度认知障碍或阿尔茨海默病的评价方法>
如下述实施例中所示,在轻度认知障碍者或阿尔茨海默病患者与健康者之间,对肠内微生物群进行比较,结果明确了与宿主的认知功能有关联的肠内微生物。因此,本发明也提供以这些肠内微生物量为指标,判定轻度认知障碍或阿尔茨海默病的罹患的以下方法。
(轻度认知障碍的评价方法1)
一种方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述微生物为选自由属于粪杆菌属的微生物、属于瘤胃球菌科的属名不明的微生物、属于厌氧棒杆菌属的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌属的微生物、及属于瘤胃球菌属的微生物组成的组中的至少1种微生物。
(轻度认知障碍的评价方法2)
一种方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述微生物为选自由属于普雷沃菌属的微生物组成的组中的至少1种微生物。
(阿尔茨海默病的评价方法1)
一种方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者罹患了阿尔茨海默病的工序,并且上述微生物为选自由属于布劳特氏菌属的微生物、属于纺锤链杆菌属的微生物、属于瘤胃球菌属的微生物、及属于真杆菌属的微生物组成的组中的至少1种微生物。
(阿尔茨海默病的评价方法2)
一种方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者罹患了阿尔茨海默病的工序,并且上述微生物为选自由属于副拟杆菌属的微生物组成的组中的至少1种微生物。
作为在本发明的评价方法中成为其定量对象的属于粪杆菌(Faecalibacterium)属的微生物,可列举例如普氏栖粪杆菌(Faecalibacterium prausnitzii)、莫雷栖粪杆菌(”Faecalibacterium moorei”)。
作为属于厌氧棒杆菌(Anaerostipes)属的微生物,可列举例如丁酸厌氧棒杆(Anaerostipes butyraticus)、粪厌氧棒杆(Anaerostipes caccae)、庞大厌氧棒杆(Anaerostipes hadrus)、食鼠李糖厌氧棒杆(Anaerostipes rhamnosivorans)。
作为属于巴恩斯氏菌(Barnesiella)属的微生物,可列举例如肠道巴恩斯氏菌(Barnesiella intestinihominis)、肠居巴恩斯氏菌(Barnesiella viscericola)。
作为属于普雷沃菌(Prevotella)属的微生物,可列举例如苏格兰普雷沃菌(Prevotella albensis)、羊水普雷沃菌(Prevotella amnii)、奥兰蒂亚克普雷沃菌(Prevotella aurantiaca)、巴氏普雷沃菌(Prevotella baroniae)、卑尔根普雷沃菌(Prevotella bergensis)、普雷沃菌(Prevotella bivia)、二路普雷沃菌(Prevotellabrevis)、Prevotella brunnea、布氏普雷沃菌(Prevotella bryantii)、颊普雷沃菌(Prevotella buccae)、口颊普雷沃菌(Prevotella buccalis)、Prevotella cerevisiae、彩色普雷沃菌(Prevotella colorans)、粪便普雷沃菌(Prevotella copri)、人体普雷沃菌(Prevotella corporis)、牙普雷沃菌(Prevotella dentalis)、普雷沃菌丹塔(Prevotelladentasini)、栖牙普雷沃菌(Prevotella denticola)、解糖胨普雷沃菌(Prevotelladisiens)、栖居普雷沃菌(Prevotella enoeca)、斐氏普雷沃菌(Prevotella falsenii)、深黑色普雷沃菌(Prevotella fusca)、解肝素普雷沃菌(Prevotella heparinolytica)、栖组织普雷沃菌(Prevotella histicola)、人普雷沃菌(Prevotella hominis)、中间普雷沃菌(Prevotella intermedia)、空肠普雷沃菌(Prevotella jejuni)、韩国普雷沃菌(”Prevotella koreensis”)、洛氏普雷沃菌(Prevotella loescheii)、小斑点普雷沃菌(Prevotella maculosa)、马赛普雷沃菌(”Prevotella marseillensis”)、马氏普雷沃菌(Prevotella marshii)、马赛白袍普雷沃菌(”Candidatus Prevotella massiliensis”)、产黑素普雷沃菌(Prevotella melaninogenica)、彩虹普雷沃菌(Prevotella micans)、多形普雷沃菌(Prevotella multiformis)、食多糖普雷沃菌(Prevotellamultisaccharivorax)、南充普雷沃菌(Prevotella nanceiensis)、变黑普雷沃菌(Prevotella nigrescens)、口腔普雷沃菌(Prevotella oralis)、口普雷沃菌(Prevotellaoris)、米普雷沃菌(Prevotella oryzae)、龈炎普雷沃菌(Prevotella oulorum)、苍白普雷沃菌(Prevotella pallens)、沼泽普雷沃菌(Prevotella paludivivens)、”Prevotellapectinovora”、Prevotella phocaeensis、胸膜炎普雷沃菌(Prevotella pleuritidis)、Prevotella rara、栖瘤胃普雷沃菌(Prevotella ruminicola)、解糖普雷沃菌(Prevotellasaccharolytica)、唾液普雷沃菌(Prevotella salivae)、头颈普雷沃菌(Prevotellascopos)、赛赫普雷沃菌(Prevotella shahii)、斯特塞拉普雷沃菌(Prevotellastercorea)、蒂莫内普雷沃菌(Prevotella timonensis)、真空腔普雷沃菌(Prevotellaveroralis、”Prevotella vespertina”)、动胶普雷沃菌(Prevotella zoogleoformans)、”Prevotella ihumii”、”Prevotella lascolaii”、直肠普雷沃菌(”Prevotellarectalis”)。
作为属于布劳特氏菌(Blautia)属的微生物,可列举例如阿氏布劳特氏菌(Blautia argi)、盲肠布劳特氏菌(Blautia caecimuris)、球形布劳特氏菌(Blautiacoccoides)、栖粪布劳特氏菌(Blautia faecicola)、粪布劳特氏菌(Blautia faecis)、甘油布劳特氏菌(Blautia glucerasea)、汉氏布劳特氏菌(Blautia hansenii)、人布劳特氏菌(Blautia hominis)、氢营养型布劳特氏菌(Blautia hydrogenotrophica)、泥布劳特氏菌(Blautia luti)、卵形布劳特氏菌(Blautia obeum)、生产布劳特氏菌(Blautiaproducta)、Blautia schinkii、粪便布劳特氏菌(Blautia stercoris)、韦氏布劳特氏菌(Blautia wexlerae)、”Blautia marasmi”、马赛布劳特氏菌(”Blautia massiliensis”)、”Blautia phocaeensis”、”Blautia provencensis”。
作为属于纺锤链杆菌(Fusicatenibacter)属的微生物,可列举例如食糖纺锤链杆菌(Fusicatenibacter saccharivorans)。
作为属于瘤胃球菌(Ruminococcus)属的微生物,可列举例如白色瘤胃球菌(Ruminococcus albus)、布氏瘤胃球菌(Ruminococcus bromii)、伶俐瘤胃球菌(Ruminococcus callidus)、查帕希斯瘤胃球菌(Ruminococcus champanellensis)、生黄瘤胃球菌(Ruminococcus flavefaciens)、高氏瘤胃球菌(Ruminococcus gauvreauii)、瘤胃球菌(Ruminococcus gnavus)、乳牛瘤胃球菌(Ruminococcus lactaris)、扭链瘤胃球菌(Ruminococcus torques)、双环瘤胃球菌(”Ruminococcus bicirculans”)。
作为属于真杆菌属(Eubacterium)属的微生物,可列举例如聚集真杆菌(Eubacterium aggregans)、巴克氏真杆菌(Eubacterium barkeri)、短真杆菌(Eubacterium brachy)、卡氏真杆菌(Eubacterium callanderi)、溶纤维真杆菌(Eubacterium cellulosolvens)、产粪甾醇真杆菌(Eubacterium coprostanoligenes)、较弱真杆菌(Eubacteriuminfirmum)、粘液真杆菌(Eubacterium limosum)、Eubacteriummaltosivorans、细小真杆菌(Eubacterium minutum)、多形真杆菌(Eubacteriummultiforme)、纠缠真杆菌(Eubacterium nodatum)、氧化还原真杆菌(Eubacteriumoxidoreducens)、蝇尾真杆菌(Eubacterium plexicaudatum)、Eubacteriumpyruvativorans、细枝真杆菌(Eubacterium ramulus)、瘤胃真杆菌(Eubacteriumruminantium)、隐藏真杆菌(Eubacterium saphenum)、惰性真杆菌(Eubacteriumsiraeum)、沟迹真杆菌(Eubacterium sulci)、纤细真杆菌(Eubacterium tenue)、多曲真杆菌(Eubacterium tortuosum)、单形真杆菌(Eubacterium uniforme)、凸腹真杆菌(Eubacterium ventriosum)、嗜木聚糖真杆菌(Eubacterium xylanophilum)、尤里真杆菌(Eubacterium yurii)。
作为属于副拟杆菌属(Parabacteroides)属的微生物,可列举例如产酸副拟杆菌(Parabacteroides acidifaciens)、罗纳河口副拟杆菌(”Parabacteroidesbouchesdurhonensis”)、Parabacteroides chartae、Parabacteroides chinchillae、Parabacteroides chongii、狄氏副拟杆菌(Parabacteroides distasonis)、粪副拟杆菌(Parabacteroides faecis)、戈氏副拟杆菌(Parabacteroides goldsteinii)、Parabacteroides gordonii、约氏副拟杆菌(Parabacteroides johnsonii)、马赛副拟杆菌(”Parabacteroides massiliensis”)、粪副拟杆菌(Parabacteroides merdae)、”Parabacteroides pacaensis”、”Parabacteroides provencensis”、副拟杆菌(”Parabacteroides timonensis”)。
需要说明的是,被””夹着的名字表示“未正式公布”。
作为属于瘤胃球菌(Ruminococcaceae)科的属名不明的微生物,例如可列举如下微生物,其含有与序列号:423~497记载的核苷酸序列中的至少1种序列具有80%以上的同源性的DNA。
作为属于CAG-41属的微生物,例如可列举如下微生物,其含有与序列号:498~504记载的核苷酸序列中的至少1种序列具有80%以上的同源性的DNA。
本发明的“同源性”如上所述,核苷酸序列的同源性也可利用BLAST等比对程序确定。例如,核苷酸序列的同源性可列举使用blastn算出的核苷酸序列间的同源性,更具体而言,可列举对blastn使用默认参数(即使用初始设定的参数)算出的核苷酸序列间的同源性。
需要说明的是,与核苷酸序列相关的此处的“同源性”如上所述,例如为80%以上(更具体而言,81%以上、82%以上、83%以上、84%以上)、优选为85%以上(例如86%以上、87%以上、88%以上、89%以上)、更优选为90%以上(例如91%以上、92%以上、93%以上、94%以上)、进一步优选为95%以上(例如96%以上、97%以上、98%以上、99%以上)、特别优选为100%。
在本发明的各评价方法中成为定量对象的微生物只要为至少1种即可,优选为2种以上(例如3种以上、4种以上),更优选为5种以上(例如6种以上、7种以上、8种以上、9种以上),进而优选为10种以上。
本发明的评价方法中的“被检者”没有特别限定,与上述“脑功能下降的预防等的对象”同样。另外,成为其比较对象的“健康者”也没有特别限定,优选为年龄、性别、人种或国籍、及痴呆症以外的既往史中的至少一个特征与上述被检者同样。
“粪便中的微生物的定量”可不测定该微生物的量(数)本身,例如可通过测定反映该微生物的量(数)的该微生物特有的物质的量来进行。作为该物质,可列举:上述微生物特异性寡核苷酸(例如16SrRNA基因、及其转录物)、上述微生物特有的构成物质(构成该微生物的肽、核酸、糖、脂质、及这些的复合体等)、该微生物的产物(例如该微生物的分泌产物、该微生物的代谢产物)。
物质为寡核苷酸时,例如可使用如下方法进行定量:PCR(RT-PCR、实时PCR、定量PCR)、DNA微阵列分析法、RNA印迹法、下一代测序法(合成测序法(sequencing-by-synthesis,例如利用Illumina公司制造的Solexa基因组分析仪或Hiseq(注册商标)2000的测序)、焦磷酸测序法(例如利用Roche Diagnostics(454)公司制造的测序仪GSLX或FLX的测序(所谓454测序))、连接酶反应测序法(例如利用Life Technology公司制造的SoliD(注册商标)或5500xl的测序)、T-RFLP法、微珠阵列法、原位杂交、点印迹法、RNase保护分析法、质谱法、基因组PCR法、DNA印迹法。
关于其它物质,例如可使用如下方法进行定量:ELISA法、免疫印迹法、抗体阵列分析法、免疫组织化学染色法、流式细胞分析法、成像细胞计数法、放射免疫分析法、免疫沈淀法等使用抗体进行检测的方法(免疫学方法)。
另外,如此进行定量所获得的值不仅可为绝对量,也可为相对值。作为相对值,例如可列举基于用于检测的测定方法或测定装置的量比(所谓以任意单位(AU)表示的数值)。另外,作为相对值,例如,如下述实施例所示,也可为表示该微生物在肠内微生物群整体中的比率的值(相对丰度、占有率)。另外,也可使用以参照肠内微生物的量为基准算出的值。本发明的“参照肠内微生物”只要为稳定地存在于粪便试样中,另外在不同的生物试样间其量的差较小的微生物即可。
另外,如下述实施例中所示,在轻度认知障碍者与健康者之间,对特定DNA量进行比较,结果明确了与宿主的认知功能有关联的DNA。因此,本发明也提供以这些DNA的量为指标来判定轻度认知障碍的状态的以下方法。
(轻度认知障碍的评价方法3)
一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的DNA进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述DNA进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值低于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且上述DNA为下述(a)~(i)中的至少1种DNA,
(a)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(b)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:158记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(c)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:204记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(d)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:205记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(e)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:206记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(f)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:365记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(g)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:414记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(h)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:420记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(i)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:421记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
(轻度认知障碍的评价方法4)
一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的DNA进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的上述DNA进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的上述定量值高于上述对应值时,判定上述被检者为轻度认知障碍的状态的工序,并且
上述DNA为包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:297记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
关于在本发明的各评价方法中成为定量对象的“包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列”如上所述。另外,除了该DNA以外,包含编码在序列号:N记载的核苷酸序列所编码的氨基酸序列中置换、缺失、添加、和/或插入了1个或多个氨基酸的氨基酸序列的核苷酸序列的DNA;或与由序列号:N记载的核苷酸序列构成的DNA在严格的条件下杂交的DNA也可成为定量对象,这些DNA也如上所述。
在本发明的各评价方法中成为定量对象的DNA只要有至少1种即可,上述“轻度认知障碍的评价方法3”中,优选为2种以上(例如3种以上、4种以上),更优选为5种以上(例如6种以上、7种以上、8种以上、9种以上)。
在“轻度认知障碍的评价方法3及4”中,“被检者”也如上所述。“粪便中的DNA的定量”可不测定该DNA(基因组DNA)的量(数)本身,例如可通过测定反映该DNA的量(数)的物质的量来进行。作为该物质,可列举:转录产物(mRNA)、cDNA、翻译产物(肽)。另外,如上所述,本领域技术人员可根据物质的种类适宜地采用公知的定量方法,进行这些物质的定量。
另外,如此进行定量所获得的值不仅可为绝对量,也可为相对值。作为相对值,例如可列举基于用于检测的测定方法或测定装置的量比(所谓以任意单位(AU)表示的数值)。另外,作为相对值,例如也可为表示粪便中的成为定量对象的DNA在全部DNA中的比率的值(相对丰度、占有率)。另外,也可使用以参照量作为基准算出的值。关于本发明的“参照量”,只要为稳定地存在于粪便试样中,且于不同的生物试样间其量的差较小的DNA即可。
本发明的评价方法(上述“阿尔茨海默病的评价方法1及2”、以及“轻度认知障碍的评价方法1及2~4”)中,对进行定量所获得的值与健康者的该值(对应值)进行比较。本领域技术人员可适当选择依据上述检测方法的统计学分析方法而进行该比较。作为统计学分析方法,例如可列举:t检验、Wilcoxon的符号秩检验、分散分析(ANOVA)、Kruskal-Wallis检验、曼-惠特尼的U检验(Wilcoxon秩和检验)、胜算比、风险比、Fisher's精确检验、受试者工作特征分析(ROC分析)、分类树与判定树分析(CART分析)。另外,比较时也可使用经正规化或经标准化且正规化的数据。
轻度认知障碍或阿尔茨海默病罹患的判定通常由医师(也包含接受了医师的指示者)进行,与上述微生物量或DNA量等相关的数据有助于也包含医师的治疗时机等的判断在内的诊断。因此,本发明的方法也可表述为:为了医师的诊断而收集与上述微生物量或DNA量等相关的数据的方法、向医师出示该数据的方法、对上述微生物量或DNA量等与上述对应值进行比较并分析的方法、考虑患者的临床症状和/或其它检查结果后用于辅助医师的诊断的方法。
实施例
以下,基于实施例更具体地说明本发明,但本发明并不限定于以下的实施例。
(实施例1)流行病学试验
为了筛选与宿主的脑功能相关的肠内微生物(肠内细菌),通过分别自认知功能等脑功能正常者(健康者)、轻度认知障碍(MCI)者及罹患阿尔茨海默病(AD)者采集粪便,并对各粪便中的肠内微生物的构成,对这些微生物的16SrRNA序列进行测序而加以分析。
具体而言,自参加了2015年于群马县草津町(日本)进行的健康诊断的人中,请健康者21名、MCI者15名作为本流行病学试验的被检者(平均65岁以上)参加。另外,自居住于草津町的老人院的人、草津町公共护理服务的利用者、及参加了同年的健康诊断的人中,请7名65岁以上的AD罹患者作为被检者参加。
需要说明的是,以下人士排除在被检者之外:
(1)粪便采集前2周内使用了抗生素者、
(2)过去半年接受过消化道的外科手术者、
(3)有炎症性肠疾病、炎症性肠道综合征、消化道中的肿瘤及胃切除术等与消化道障碍相关的既往史者、
(4)有糖尿病的既往史者、及
(5)有AD以外的任一种显著的神经学及精神疾病的既往史者。
另外,对全部被检者详细说明由东京都健康长寿医疗研究中心的伦理委员会核准的研究试验方案后,获得书面的知情同意。
被检者的评价如下进行:
(1)通过精神状态短时间检查(MMSE(Mini-Mental Status Examination,简易智能状态测验))、蒙特利尔认知评价检查日语版(MoCA-J)及临床认知评价法(CDR(ClinicalDementia Rating,临床痴呆分级)),评价认知功能;
(2)通过老研式活动能力指标(东京都老年医学研究所的能力指数(TokyoMetropolitan Institute of Gerontology Index of Competence;TMIG-IC)),评价基本日常生活活动(ADL);
(3)进行与病历及目前的投药相关的医师问诊;
(4)使用血液检查及血压等健康诊断数据而进行。
被检者分为健康者组、MCI组及AD组这3个组。健康者与MCI者依据Petersen基准进行诊断。具体而言,在如下情形时,诊断为被检者健康:
(1)无记忆自述症状、
(2)MoCA-J≥26、
(3)MMSE≥24、
(4)CDR得分为0、
(5)ADL的得分为5、
(6)未罹患神经疾病及精神疾病。
另一方面,在如下情形时,诊断为被检者为MCI:
(1)存在记忆自述症状、
(2)MoCA-J≤25、
(3)MMSE≥24、
(4)CDR得分为0.5、
(5)ADL的得分为5、
(6)未罹患神经疾病及精神疾病。
AD的罹患则是使用医学面谈与问卷调查,且基于精神障碍的诊断与统计手册(DSM)-IV基准由医师进行判断。
使用采便套组(Techno Suruga Lab株式会社制造)采集粪便,并冷冻保存。并且,为了利用下一代测序仪分析各粪便中的肠内微生物的构成,制备用于供于其的文库。具体而言,首先,自所采集的粪便提取DNA。将所获得的DNA作为模板,通过PCR将16SrRNA区域(16SrRNA的V3-V4区域)扩增以用于微生物的系统分析。PCR扩增后,使用文库制作用DNA片段分级、回收套组(Thermo Fisher Scientific公司制造、制品名:E-Gel(注册商标)SizeSelect Gels),提取包含上述目标区域的扩增产物后,进行index添加,并使用DNA纯化试剂套组(Beckman Coulter公司制造、制品名:Agencourt ampure XP beads)进行纯化。继而,对以上述方式制备的文库溶液,通过浓度测定、及使用生物分析仪(Bioanalyzer)(Agilent公司制造)的电泳,实施质量控制(QC)。然后,将各样品的文库液等摩尔混合,并利用下一代测序仪(Miseq)进行测序。
基于所获得的测序结果,进行生物信息分析,并算出肠内微生物的存在比率等。具体而言,使用微生物群落分析程序“QIIME2”及GTDB数据库算出系统组成,并通过R来提取存在显著差异的系统。将所获得的结果示于图1及2。
进行上述试验,结果获得129个属。并且,如图1及2所示,可筛选出在健康者与MCI、健康者与AD的任一组间比较中观察到显著差异的11种微生物。
其中,关于属于粪杆菌(Feacalibacterium)属的微生物、属于瘤胃球菌(Ruminococcaceae)科的属名不明的微生物、属于厌氧棒杆菌(Anaerostipes)属的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌(Barnesiella)属的微生物、及属于瘤胃球菌(Ruminococcus)属的微生物在肠内微生物群中的相对丰度,MCI者低于健康者(图1中,位于较横轴0的线更靠左的位置,且位于较P=0.05的线更靠上的位置的微生物)。另一方面,关于属于普雷沃菌(Prevotella)属的微生物的相对丰度,MCI者高于健康者(图1中,位于较横轴0的线更靠右的位置,且位于较P=0.05的线更靠上的位置的微生物)。
需要说明的是,属于瘤胃球菌科的属名不明的微生物是指虽然于上述生物信息分析中被系统指定为瘤胃球菌科,但属名不明的未分类微生物,具体而言,是具有编码16SrRNA的V3-V4区域的序列号:423~497的任一者记载的DNA序列的微生物。另外,属于CAG-41属的微生物是具有编码16SrRNA区域的V3-V4区域的序列号:498~504的任一者记载的DNA序列的微生物。
另外,关于属于布劳特氏菌(Blautia)属的微生物、属于纺锤链杆菌(Fusicatenibacter)属的微生物、属于瘤胃球菌(Ruminococcus)属的微生物、及属于真杆菌(Eubacterium)属的微生物在肠内微生物群中的相对丰度,AD患者低于健康者(图2中,位于较横轴0的线更靠左的位置,且位于较P=0.05的线更靠上的位置的微生物)。另一方面,关于属于副拟杆菌(Parabateroides)属的微生物的相对丰度,AD患者高于健康者(图2中,较横轴0的线更靠右且较P=0.05的线更靠上的微生物)。
因此,提示以上的肠内微生物与宿主的脑功能(认知功能等)相关。
然后,为了分析在健康者与MCI者、健康者与AD患者中的任一组间比较中观察到显著差异的微生物的相对丰度(relative abundance)与认知功能测试MoCA-J的结果的关联,以健康者及MCI者为对象,进行Spearman相关分析。将所获得的结果示于表1。
[表1]
如表1所示,上述分析的结果为,在一些属中观察到有意义的关联。尤其是,普氏栖粪杆菌(Fp)除了确认到有意义的关联以外,相对丰度本身较高,如图1所示,在健康者与MCI者中确认到相对丰度的显著差异,因此在以下的实施例中,着眼于属于粪杆菌属的微生物而进行分析。
(实施例2)分离试验
如上所述,在实施例1中,在属的水平上发现了与脑功能相关的肠内微生物。因此,在厌氧下培养健康者及MCI者的粪便,分离出属于上述属的菌株。
具体而言,首先,将健康者及MCI者的粪便分别在厌氧室内(N2=90%、CO2=5%、H2=5%)逐级稀释至10-5~10-7。将所获得的各粪便稀释液涂布在YCFA琼脂培养基、EG琼脂培养基、或在这些培养基中添加有抗生素的培养基。在37℃下培养1~2天后,自生长的菌落中拾取约7000个菌落,反复进行所需次数的传代,由此使菌落单一化。经单一化的分离株在20%甘油溶液中于-80℃下保存。
另外,在即将保存分离株前,使一部分菌体悬浮于添加有玻璃珠的5%Triton溶液中,进行均质化,由此提取分离株的DNA。然后,使用用于扩增16SrRNA基因的通用引物组(27F引物及1492R引物)进行PCR,由此自所提取的DNA扩增16SrRNA基因。继而,使用27F引物实施PCR扩增产物的测序。对所获得的序列数据,以3种数据库(NCBI、Eztaxon、Ltp)实施BLAST分析,确定分离株的菌种。
具体而言,分离、确定12种普氏栖粪杆菌(Fp)株(Fp1、Fp4、Fp14、Fp28、Fp40、Fp45、Fp77、Fp137、Fp360、Fp944、Fp1043、Fp1160)。需要说明的是,仅Fp944来自MCI者,剩余11株来自健康者。
(实施例3)有效性动物试验1
与脑功能相关的肠内微生物中,关于实施例2中分离、确定的上述12种Fp株,对向脑室内给予了淀粉样蛋白β的小鼠短时间(11天)给予各菌株,并使用Y迷宫试验及被动回避试验评价该小鼠的学习记忆障碍的改善程度。
具体而言,在厌氧室内,将Fp株转移至YCFA培养基中,在37℃下培养24小时。其后,使培养液在LYBHI培养基中进行传代(接种体积:5%),进而培养24小时或48小时。将该培养液离心浓缩,并用作被检物质。需要说明的是,被检物质以其20倍稀释的浊度(McFARLANDSCALE)成为0.6(相当于6.6×108cells/mouse(个细胞/小鼠))的方式调整。被检物质在对小鼠给予前于-80℃下保存。
小鼠使用Slc:ddY雄性小鼠(5周龄)。Fp株等被检物质1天1次、反复经口给予11天。在其给予第3天向脑室内单次给予淀粉样蛋白β。另外,设定以下的组作为对照。
对照组1:向脑室内给予注射用水,且经口给予介质(生理盐水)的假手术组、
对照组2:向脑室内给予淀粉样蛋白β,且经口给予介质(生理盐水)的介质对照组、
对照组3:向脑室内给予淀粉样蛋白β,且经口给予介质(培养基)的介质对照组、
对照组4:向脑室内给予淀粉样蛋白β,且以0.5mg/kg体重经口给予Aricept(多奈哌齐盐酸盐)的对照组
需要说明的是,以每组9只设定各被检物质组及上述各对照组。
在给予第9天在被检物质给予1小时后进行Y迷宫试验,在给予第10~11天在被检物质给予1小时后进行被动回避试验。
Y迷宫试验使用如下塑料制的Y字型迷宫,其1条臂的长度为39.5cm,地板的宽度为4.5cm,壁的高度为12cm,且3臂分别以120度进行分支。将上述小鼠置于Y字型迷宫中的任一条臂,使其在迷宫内自由地探索7分钟。记录小鼠在测定时间内进入的臂的顺序,数出进入臂的次数,设为总进入数。其次,数出其中3次连续进入不同的臂的次数,将该数设为自主交替行为数。进而使用下式算出自主交替行为率。测定是在观察者不清楚组信息的状况(盲)下进行的。
自主交替行为率(%)=[自主交替行为数/(总进入数-2)]×100
将所获得的结果示于图3。
被动回避试验使用避暗(step through)型被动回避反应装置,其具备被中央的闸门分隔的明室(W:100×D:100×H:300mm)、及自地板的电网施加电刺激的暗室(W:240×D:245×H:300mm)。使动物进入明室,10秒后安静地打开闸门,测定至动物进入暗室为止的时间(反应潜伏时间)。获得尝试(给予10天)是在动物进入暗室的同时关闭闸门,施加电刺激(0.2mA、2sec、快速移动方式(scramble)),确认施加电刺激时有无动物的叫声。反应潜伏时间的测定设为最长300秒。关于保持尝试(给予11天),动物进入暗室、或在明室内经过300秒即设为结束。将所获得的结果示于图4。
进行上述Y迷宫试验,结果如图3所示,在Fp14、Fp28、Fp77及Fp360中,与培养基给予组进行比较,确认到自主交替行为率的统计学上显著的改善。另外,进行上述被动回避试验,结果如图4所示,在Fp360中,与培养基给予组进行比较,确认到反应潜伏时间的统计学上显著的增加。进而,继Fp360后,在Fp1043及Fp14中也确认到反应潜伏时间的增加的可能性。因此,这些Fp株、尤其是Y迷宫试验及被动回避试验这两者中提示了有效性的Fp14及Fp360确认到对学习、记忆障碍等脑功能下降发挥改善效果的可能性。
(实施例4)有效性动物试验2
在实施例3中,关于提示了对脑功能下降的改善效果的Fp14及Fp360,对这些的培养上清液及死菌体也评价学习记忆障碍的改善程度。培养上清液及死菌体通过以下方法制备。
<培养上清液的制备方法>
在厌氧室内,将Fp株的储备菌液在YCFA培养基中进行培养(37℃、24小时)。进而,以接种体积成为5%的方式,将培养液在LYBHI培养基中进行传代培养(37℃、24小时)。对培养液进行离心分离(800×g、室温、10分钟)及过滤器(0.22μm孔径)处理,获得培养上清液。培养上清液在对动物给予前于-80℃下保存。
<死菌体溶液的制备方法>
在厌氧室内,将Fp株的储备菌液在YCFA培养基中进行培养(37℃、24小时)。进而,以接种体积成为5%的方式,将培养液在LYBHI培养基中进行传代培养(37℃、24小时)。对培养液进行离心分离(800×g、室温、10分钟),去除上清液后,实施2次使用生理盐水的离心清洗。以与活菌被检体的制备成为同样的浊度的方式,使用生理盐水使所获得的菌体悬浮,并进行加热处理(70℃、30分钟),由此获得死菌体溶液。死菌体溶液在对动物给予前于-80℃下保存。
然后,将以上述方式制备的培养上清液及死菌体溶液作为被检物质,与实施例3中所记载的方法同样地,对向脑室内给予了淀粉样蛋白β的小鼠短时间(11天)给予,并使用Y迷宫试验及被动回避试验评价该小鼠的学习记忆障碍的改善程度(以每组12只设定各被检物质组及上述各对照组)。将所获得的结果示于图5及6。
进行Y迷宫试验,结果如图5所示,也如实施例3(图3)中所示,关于Fp14及Fp360的两者,确认到活菌给予的改善效果及改善倾向。进而,通过给予Fp360的死菌体,与培养基给予组进行比较,确认到自主交替行为率的改善倾向。
另外,进行被动回避试验,结果如图6所示,也如实施例3(图4)中所示,关于Fp360,确认到活菌给予的改善效果。另一方面,关于Fp14,通过制成死菌体,与生理盐水给予组进行比较,明确统计学上反应潜伏时间显著地增加。
(实施例5)全基因组分析1
进行了如下尝试:对于在实施例3及4中在Y迷宫试验及被动回避试验这两者中提示了对脑功能下降的有效性的Fp株(Fp14及Fp360)、与在任一试验中均未观察到对脑功能下降的有效性的Fp株(上述2株以外的10株),依据图7所示的管线,对全基因组进行比较,并于前者中提取特征性基因。
具体而言,首先,在厌氧室内,将Fp株转移至YCFA培养基中,在37℃下培养24小时。其后,在800×g、10分钟、4℃下离心后,废弃上清液,利用厌氧PBS清洗。其后,重复进行离心及PBS清洗2次,将菌体颗粒冷冻保存。
由菌体颗粒,使用基因组DNA纯化用阴离子交换柱与其专用缓冲液(制品名:NucleoBond(注册商标)AXG 20、NucleoBond Buffer Set III、均为MACHEREY NAGEL公司制造)制备基因组DNA。进而,利用DNA片段化管(制品名:g-TUBE、Covaris公司制造),将该基因组DNA以物理方式片段化。
为了将这些片段化DNA供于下一代测序(PacBio测序),首先,将片段化后的DNA的两末端平滑化,之后连接SMRTbell接头,制作成为测序模板的序列文库(SMRTbell模板)。所制作的SMRTbell模板通过脉冲场电泳确认尺寸分布,使用自动DNA片段凝胶提取装置(制品名:BluePippin、Sage Science公司制造)或DNA纯化试剂(制品名:AMPure XP、BeckmanCoulter公司制造)进行尺寸选择。继而,使具有与序列文库两末端的SMRTbell接头互补的序列的序列引物与DNA聚合酶结合,制成测序模板。使该模板与磁珠结合,并应用于SMRT(注册商标)Cell上,将测序模板固定于孔(Zero-mode waveguides;ZMW)内,利用单分子实时DNA测序仪(制品名:PacBio RS II、Pacific Biosciences公司制造)进行测序反应。
然后,对测序中所获得的读长(reads)使用测序仪附属的软件SMRT Analysis进行从头(de novo)装配。对通过装配所获得的片段进行拼接(contig),使用Circlator管线进行以下的处理。
首先,去除全长包含于其它片段拼接中者。继而,对两末端重叠者进行环状化后,使用dnaA基因序列进行基因组序列起始位置的修正。其后,使用Quiver进行再校准。在再校准中,对进行环状化处理等后的片段拼接(一致序列)进行子测序片段(subreads)的映射,基于其结果进行一致序列的修正。另外,基因组的完整性及污染可由CheckM(v1.0.08)进行判定。
然后,使用Prokka(v1.12)进行所获得的环状全基因组的序列中的基因(编码区域(CDS))的预测及基因组的批注。
接着,基于上述所预测的基因信息,利用2个不同的种间同源基因探索工具(Roary(v3.12.0)、Orthofinder(v2.3.11))鉴定种间同源基因。需要说明的是,Roary及Orthofinder在以下的条件下进行。
(1)Roary
主要以BLASTP的同一性70%以上的同源性聚类为相同的种间同源基因(参照Bioinformatics、31卷、22号、2015年11月15日发行、3691~3693页)。
(2)Orthofinder
以orthofinder单独的阈值聚类为种间同源基因。更具体而言,使用all vs all的blastp的二进制值(bit score)算出orthofinder单独的得分(标准得分(normalizedscore))后,当在某查询(query)中为RBNH(Reciprocal Best length-Normalized hit(倒数最佳长度-归一化命中)=normalized score于双向为最佳命中(best hit))、或为存在标准得分的查询的最低的RBNH以上时,聚类为相同的种间同源基因(参照GenomeBiol.2015年8月6日;16(1):157)。
另外,对上述所预测的基因使用Diamond(v0.9.10.111、同一性的阈值>40、得分>70、及范围(coverage)>80),对KEGG基因及KEGG种间同源基因(KO)进行批注(所参照的KO数据为2017年5月时者)。继而,将KO分配为利用Roary或Orthofinder鉴定的种间同源基因。
另外,基于上述所预测的基因信息,使用InterProScan(v5.40-77.0)及TMHMM(v2.0)进行蛋白质结构域的预测。需要说明的是,在TMHMM中,在整个序列被分类为内部或外部时,预测其不含细胞膜蛋白、为细胞内蛋白或细胞外蛋白。另一方面,在整个序列被分类为至少1个跨膜螺旋(transmembrane helix)时,预测为跨膜蛋白。
然后,以上述方式鉴定各Fp株所特有的序列(基因)的种间同源基因、及包含各Fp株所特有的KO的种间同源基因(以下,将这些总称为“独特的种间同源基因”)。
将所提取的Fp14及Fp360这两种Fp株所特有的序列的种间同源基因示于表2。
[表2]
需要说明的是,“ICBIDGAJ”及“BLCPAMOF”表示在Fp14及Fp360的全基因组分析中,利用Prokka预测的各基因所附的ID(Identity,标识符)。另外,将这些基因的序列分别示于序列号:1~27及29~57。另外,在表2中,横排的基因彼此(例如ICBIDGAJ_00324(序列号:9)与BLCPAMOF_01513(序列号:30))为种间同源基因的关系。
另外,提取ICBIDGAJ_00537与BLCPAMOF_00623(序列号:28与序列号:422)作为表征Fp14及Fp360的独特的与KO1684相对应的基因。
以上结果为,提取出表征Fp14及Fp360的独特的28个种间同源基因。其中,如图8所示,在使用Roary及Orthofinder这两种分析中共通地提取出的3种种间同源基因在基因组上连续地存在。另外,结构域分析的结果为,预测这些3种种间同源基因系利用TMHMM编码跨膜域或菌体外域。
(实施例6)全基因组分析2
接着,以与实施例5中所记载的方法同样的方式,在Fp14与包含Fp360的其它11株中,对全基因组进行比较,提取仅Fp14特征性的基因及KO。
结果,可在Roary及Orthofinder这两种分析中,共通地筛选出与序列号:58~207记载的DNA序列对应的Fp14所特有的150个种间同源基因。其中,在仅表征Fp14的独特的146个基因(表示为序列号:58~203)中,着眼于连续的基因,结果确认到未知的分别编码菌体外蛋白或菌毛相关蛋白的基因连续地排列的区域(参照图9)。
另外,提取与序列号60、110、140及204~207记载的核苷酸序列对应的8个KO作为仅表征Fp14的独特的KO。这些中,KO1226(ICBIDGAJ_00755(序列号:205))、KO2818及KO2819(ICBIDGAJ_00754(序列号:204))、以及KO3486(ICBIDGAJ_00753(序列号:206))为与海藻糖相关的KO,如图10所示,与仅表征Fp14的独特的基因(ICBIDGAJ_00757及00756)邻接。另外,KO2819及KO1226为与摄入菌体外的海藻糖而产生海藻糖-6P等的代谢途径(由细胞外海藻糖经由海藻糖-6P而生成D-葡萄糖-6P的途径)相关的KO。
(实施例7)全基因组分析3
其次,以与实施例5中所记载的方法同样的方式,在Fp360与包含Fp14的其它11株中,对全基因组进行比较,提取仅Fp360特征性的基因及KO。
结果,可在Roary及Orthofinder这两种分析中,共通地筛选出与序列号:208~421记载的DNA序列对应的Fp360所特有的214个种间同源基因。其中,提取仅表征Fp360的独特的197个基因(表示为序列号:208~404)。另外,提取分别与序列号212、228、229、238、247、249、257、274、276、279、290、296、309、335、336、337、342、371、377、及405~421记载的核苷酸序列对应的36个KO作为仅表征Fp360的独特的KO。这些中,作为连续排列的KO,确认到与细胞分裂相关的KO等。
(实施例8)宏基因组(metagenome)分析
在实施例1中的流行病学试验中所制备的肠内宏基因组样品中,在实施例5~7中所提取的确认到对脑功能下降的有效性的Fp株(Fp14和/或Fp360)中检测独特的种间同源基因在肠内微生物群中的相对丰度。并且,在组间比较这些相对丰度(健康者与MCI者的比较、健康者与AD患者的比较)。
具体而言,首先,进行全部宏基因组基因枪测序。使用TrueSeq Nano DNA文库制备套组(Illumina公司制造)制备测序文库。使用Agilent 2100生物分析器确认文库的质量。以实施例1中获得的粪便试样为对象的全部宏基因组基因枪测序利用HiSeq2500平台(Illumina公司制造)进行。关于所有试样,通过150bp的测序片段(reads)的长度,进行对于15.0Gb的目标数据尺寸的双端测序。
结果,合计6,421,909,374(平均149,346,730)个双端的reads覆盖合计963,286,406,100(平均22,402,009,444)个碱基对。
其次,为了质量管理,废弃包含文字“N”(未识别的基本对)的原始reads。包含噬菌体phiX DNA序列的reads通过使用Bowtie 2(版本2.2.9),利用其选项(fast-local)与reads进行映射而进行识别,并进行废弃。继而,使用Cutadapt(版本1.9.1),修整接头序列及引物序列的reads。连续包含17以下的质量值的reads利用Cutadapt程序去除3'末端。其次,废弃未达50个碱基对的长度的reads,另外,废弃平均质量值为25以下的reads。其次,将reads相对于人基因组进行映射(gi24 numbers:from 568336000to 568336023,http://www.ncbi.nlm.nih.gov/nuccore/568336023/,GRCh38)using Bowtie2(版本2.2.9))。然后,所映射者考虑为由人基因组衍生者,并进行废弃。最后,废弃不成对的reads。
结果,伴有934,484,415,900(平均21,732,195,719)个碱基对的合计6,229,896,106(平均144,881,305)个双端reads作为高质量的reads而获得,并供于下述肠内微生物群中的相对丰度的分析。
独特的种间同源基因在肠内微生物群中的相对丰度利用Kallisto(v0.46.2),算出TPM(transcripts per million,每百万转录本)值,基于这些进行评价。然后,使用R(3.6.3),对上述各独特的种间同源基因的相对丰度进行组间(健康者及MCI间、健康者及AD间)比较。
结果,如图8所示,关于例如为表征Fp14及Fp360的独特基因,且预测为跨膜型蛋白的ICBIDGAJ_02236及BLCPAMOF_02134的序列所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。
如图10所示,关于对Fp14独特,且预测为菌体外蛋白的ICBIDGAJ_00756所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。另外,该种间同源基因的相对丰度有健康者显著高于AD患者的倾向。
如图10所示,关于属于(分配于(assign))对Fp14独特的KO的,ICBIDGAJ_00753、00754及00755所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。
关于对Fp360独特,BLCPAMOF_02713所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。
关于对Fp360独特,属于细胞分裂相关的KO,推测为跨膜型蛋白的BLCPAMOF_00796所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。
关于对Fp360独特,属于细胞分裂相关的KO,推测为细胞内蛋白的BLCPAMOF_01742所属的种间同源基因在肠内微生物群中的相对丰度,健康者显著高于MCI者。
关于对Fp360独特,BLCPAMOF_02824所属的种间同源基因在肠内微生物群中的相对丰度,在仅利用Orthofinder的分析中,健康者显著高于MCI者。
(实施例5)长期动物有效性试验
对AD模型小鼠长时间(13个月)给予上述Fp14的培养液,通过免疫组织化学染色分析测定脑组织中的淀粉样蛋白β量。
具体而言,在厌氧室内,将Fp14转移至YCFA培养基中,在37℃下培养24小时。其后,将培养液在LYBHI培养基中进行传代(接种体积:5%),进而培养24小时或48小时。将培养液离心浓缩,用作被检物质。被检物质于对小鼠给予前于-80℃下保存。
作为AD模型小鼠,使用APP-tg小鼠(8周龄、雄、SPF级)。对该小鼠每周4次经口给予上述被检物质13个月。在1次的经口给予中,给予357μl(稀释20倍的浊度(McFARLANDSCALE)为0.6的菌量,相当于6.6×108cells/mouse)。小鼠饲养结束后,采集小鼠的脑。所采集的脑进行正中箭头状切割,将半脑于-80℃下冷冻保存。于PFA(Paraformaldehyde,多聚甲醛)固定液(0.1%戊二醛+4%多聚甲醛)中浸渍固定。
然后,将经PFA固定的半脑供于蔗糖置换,其后进行包埋,通过使用冷冻切片机(Cryostat)(Leica公司制造,CM1860)的冷冻切削,制备40μm的薄切切片。利用PBS将悬浮切片清洗2次后,于柠檬酸缓冲液中进行121℃、15分钟的高压釜处理,进行抗原活化。确认柠檬酸缓冲液恢复至室温,利用PBS清洗1次后,于添加有0.1% TritonX-100(w/v)的PBS(以下称为T-PBS)中反应30分钟,由此进行膜透过处理。使用Blocking One Histo(NacalaiTesque公司制造)进行封闭处理,于4℃下与生物素标记抗体(抗β-淀粉样蛋白(17-24)、小鼠单纯系(4G8)、生物素(TOMY DIGITAL BIOLOGY株式会社,型号:800704))反应一夜。通过与荧光标记链霉亲和素进行反应,标记靶蛋白,使用共聚焦激光显微镜(Zeiss公司制造,LSM700)获取荧光图像。然后,基于所获得的图像数据,分析皮质、海马体、及这些中是反映堆积淀粉样蛋白β量的老年斑占有率。
如图11所示,确认到通过给予Fp14而AD模型小鼠的海马体区中的淀粉样蛋白β的堆积量减少的倾向。认为AD的发病、发展由在脑内生成的淀粉样蛋白β纤维化、凝聚并堆积而引起。因此,至少Fp14与上述实施例3(有效性动物试验)的结果一并显示出对AD的预防、治疗、改善有效的可能性。
产业上的可利用性
如以上所说明,根据本发明,能够以肠内的特定微生物量为指标,进行痴呆症、或者轻度认知障碍或其前期阶段的诊断。尤其是本发明中,由于明确了分别与轻度认知障碍及阿尔茨海默病相关的肠内微生物,故也能够判别并评价这些认知功能下降。
另外,根据本发明,通过给予具有特定DNA序列的普氏栖粪杆菌株,能够预防或治疗对象的脑功能下降、尤其是认知功能下降。进而,也能够维持或改善脑功能、尤其是认知功能。
因此,本发明可用于与脑功能下降、尤其是痴呆症相关的诊断方法、预防方法、及治疗方法的开发等中。
保藏编号
(1)识别标识:Fp_0014
(2)保藏编号:NITE BP-03169
(3)受託日:2020年3月6日
(4)保藏机构:独立行政法人制品评价技术基盘机构专利微生物保藏中心(现在的国家技术评估学会,专利微生物保藏中心)
(1)识别标识:Fp_0360
(2)保藏编号:NITE BP-03196
(3)保藏日:2020年4月7日
(4)保藏机构:独立行政法人制品评价技术基盘机构专利微生物保藏中心(现在的国家技术评估学会,专利微生物保藏中心)
序列表
<110> 大塚制药株式会社(Otsuka Pharmaceutical Co., Ltd.)
国立大学法人东京工业大学(TOKYO INSTITUTE OF TECHNOLOGY)
<120> 用于预防或治疗脑功能下降或者维持或改善脑功能的组合物
<130> IBPF21-550WO
<150> JP2020-201008
<151> 2020-12-03
<160> 504
<170> PatentIn version 3.5
<210> 1
<211> 183
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(183)
<223> ICBIDGAJ _01576
<400> 1
atgacagtag cacggaaacg agcacttgca aacgcagtgg catcggcccg gatggagggg 60
ctggagatct cagagcagga aaagagagac tgcctgcgct atctggatgg aaaaatcgat 120
actgcaaccc ttgtaagaga agcattgaaa cgtcagaaaa agcaggagct gtcccggagg 180
tga 183
<210> 2
<211> 279
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(279)
<223> >ICBIDGAJ_01078
<400> 2
gtgcctagtc tgttccggct gttcggttat gtgattttct tctggagcaa tgaaggtgca 60
ccgctggaac cggttcatgt ccatgttgca aagggtgttc cgaatgccag tgcaacaaag 120
atctggatta cggaagcggg aggctgtatc gtggccaaca ataactcgaa gattcctgcc 180
agaacgttga gcgcaattgt agatgttctg gaaagccgtt caagctacat tgtggcacag 240
tggaacgatg tgtttggtga atcgaagttc tactgctga 279
<210> 3
<211> 399
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(399)
<223> ICBIDGAJ_00623
<400> 3
atgcgaaaac gatacaacac gccgcaccgc aaccgggtag tcaagacacg catgaccgag 60
gaagaatacg ccgagtttgc ggaaaggctt tctgcctgca acatgagcca agccgagttt 120
atccggcaag ccataaccgg ggcagccata cgccctatca taaccgtttc ccccgtcaac 180
gacgagctgc ttgccgctgt cgggaagctg accgccgaat acggcaggat cggcggcaac 240
ttaaaccaga tagcccggac gctgaacgag tggcacagcc cctacccgca gcttgccggg 300
gaggtacggg cggcggtttc cgaccttgct gccctaaagt ttgaagtctt gcagaaagtg 360
ggtgacgctg ttggcaacat tcaaacatat cagctctaa 399
<210> 4
<211> 195
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(195)
<223> ICBIDGAJ_02224
<400> 4
gtgaaagaag ttccgatttg gcaaaagagt aatctgacct tggaggaagc ggcggcttac 60
tctgggatcg gtatcaataa actgcggtcg atgaccgata gcgatgaatg caagttcgtc 120
ctttggaacg gaaccaaacg gcttatcaaa cgccgtaagc tggacgaata tctggacaag 180
gcattctcga tctga 195
<210> 5
<211> 639
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(639)
<223> ICBIDGAJ_01075
<400> 5
atgcgaaaaa gaatctgtgc tcttgcgtta acttccgtat ttttatgcgc ttgtctgtct 60
ggttgtagcg aatcttcaca gcctaatgct ccagcttcta attcaaacaa ttcttattct 120
agtagtacct cagataataa ttctagttca tcttctgaat caaaatctga tgaaaccaat 180
gacaattcca attcatctac tacaactaaa aaagatgcaa tttcaacacg tcttgataaa 240
atatctcatg aacgcgctca aacaggaaaa ggtgttcatg ttttgggaag ggatggtgtt 300
tggcgctggg aatatgctta tacctaccag ctgcatgtat atatcactgt aaaaaatacg 360
ggtgattacc gtgccaaagt taatagttct aactttagcg catactggga ttcctctaga 420
ttagctaact ccggtacagt atttgatgcc acctataatg aaaacggtct tgctcctggc 480
gctcagacta caataaagct aatttatgat atctccgaat atcagtataa tagttggaat 540
acccccggtc ataatattac ccttggtgtg cagtatggta atggaacatt ggcttatgtt 600
tattcaacag ataccggttc tgtaaaagca taccattaa 639
<210> 6
<211> 300
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(300)
<223> ICBIDGAJ_01076
<400> 6
atgacggccg accgcatcaa ggccctgaga gaatcgcgag ggtggacgca ggcagagctt 60
gcacgcagga tgaatatgac gagaaacggt atcaattcat gggagcaggg gctttcgatg 120
ccgtcgccgc agagcctggt ggatttggct aggctgtttt ctgtctcgac agattacctg 180
ctgggtgtag aaaagcataa tacagtaaac gtgactggtt tggatgaaaa ggatgtcgca 240
ctgattgcgc agctcgcaga acgcctgcgg agtgcggcga aaaacaatga aaacacatga 300
<210> 7
<211> 267
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(267)
<223> ICBIDGAJ_01077
<400> 7
atgctttatc cttttatgac cttgaatgat gggacggaaa tcgtttattc ctcgccaatt 60
cagaatggca atcaggagca ggtaaaggta cagattgaaa cacctgtaga aaacggcttt 120
aagtcggcga cctgtattct gccggggtat ttgtggacca ataatggcta ttctgaaatg 180
gagatggcga gcctgaaaga gctggtcaaa tcaacggcac atcttctgat ccgcttctcg 240
catgaggggg ggatcgaaag tgcctag 267
<210> 8
<211> 1233
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1233)
<223> ICBIDGAJ_02223
<400> 8
atgcaaagac gtaaagataa caaaggccgt gttctgaagg atggcgaggt ctaccgcaag 60
agtgacgggc tgtatatgta ccgttggact gcgaaaaacg gaaaacgcca taccatctat 120
gatgcaacct tggaggggct gcgcgaaaag gaagagaaga tacagcgcga cttggcagag 180
ggcatccgta tgccggagtg caatctgacc ctgaacgacc tctttgaact gtggcgtaag 240
aacaaggtgg gcttgaaaga gcataccttc gccaattacg tttatatgta caatcggttc 300
gtccgggatg agatcggcag gatgaagctc aaggacattc gcaagtcgga tatccgcagc 360
tactacaatg gcatcgtccg caatggcaag atggcgttga acacgctgga aaccatccag 420
aatgttcttc atcaggtctt tgcggtggcg gtggacgatg agtacatccg tgtgaatccc 480
acggatggtg tcctgacggc cattaaagcc gcccaccagt acgaaacgcc aaaacgccac 540
gctctgaccc tgccccagca gcaggcattc ctgagtttca tcaagaaaac gccaaaattc 600
cagcactggc tcccgatgtt cactttcatg ttgggtacgg gatgccgaat ctcggaaacg 660
gtgggtctgt gctggagtga catcgacttt gagagtgggt ttattaccat tcagcacaat 720
ctggtgtacc atgaccacga agtcggtggc tgttacttca ccatgtccac gcccaaaact 780
gccgcaggca aacgggcaat tcccatattg cccgaagttc ggaaagcgtt ggagcaggaa 840
cgagccaatc agcaggaact ggaactggtg tgtgagtacg aaatcgacgg catctcggac 900
tttgtgtttc taaaccgctt cggtcagccg cagaatccgc agaccgtcaa ccgtgctatc 960
aagcgcatca gcgttgccta caatgaagcc gaactggaaa aggccgaaaa ggcaaagcgg 1020
gaaccgcagt tattgccacc cttctcctgc cataatctcc ggcacacgtt ctgcacccgg 1080
ttgtgcgaaa acgaaaccaa cctgaaaatc attcaggaca tcatgggaca ccgggacatc 1140
aaaacgacca tggagattta cgcagaagcc accaaggaag ccaagaccca ttcctttgaa 1200
aaattgaacg gtaaactggg catttccatc tga 1233
<210> 9
<211> 1386
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1386)
<223> ICBIDGAJ_00324
<400> 9
atgggaaaat attttggaac cgatggcttc cgtggcgagg ccggtgtgaa cctgaccgcc 60
gaccacgcct acaaggtggg ccgttttctg ggctggtatt ataatgcact gcgggagcgc 120
agcggcaaca atgagcctgc ccgcatcgtc attggcaagg acacccgccg cagctcgtac 180
atgttcgagt acagcctggt ggcgggcctg accgcttccg gcgcggatgc ctacctgctc 240
cacgtcacca ccacccccag cgtggcctac attgcccgcg tagatgattt tgactgcggc 300
attatgatct ctgccagcca taacccgttc tacgacaacg gcatcaagct gatcgactgc 360
tacggcgaaa agatgcctga ggagaccctg ctgctggtgg aggactacat cgacggcaag 420
ctccatgtct ttgatcagga ctggccggag ctgccctttg cccaccggga gcatatcggc 480
tgtaccgtgg actatgtggc aggccgcaac cgctacatgg gctacctgat cagcctgggc 540
atctactcct tcaagggcat caaggtgggt ctggactgcg ccaacggtgc cagttggaac 600
attgccaaga gcgtgttcga tgcgctgggc gcagacacct atgtcatcaa caaccagccc 660
aacggcctga acatcaatct gaacgcaggc tccacccaca tcgagggcct gcagaagttt 720
gtggtggaaa agggtctgga tgtgggcttt gcctatgacg gcgatgcaga ccgctgcctc 780
tgcgtggacg aaaagggcaa tgtgatcacc ggcgaccaca tcctgtacat ctatggctgc 840
tacatgaagg agcgcggcaa actgctgacc aacaccgttg tcaccacggt catgtccaac 900
tttggtctgt acaaggcctt tgacgagcag ggcatcggct acgccaagac tgccgtgggt 960
gacaagtatg tctacgagta tatggccaag aacggctgcc gcatcggcgg tgagcagagc 1020
ggccacatca tcttctccaa gtacgccagc accggtgacg gcatcctgac cagcctgaag 1080
atgatggagg tcatgctggc caagaagaag cctctgagtg cgttggccgc cccgctgaag 1140
atctacccgc aggtgctgga aaatgtccgt gtgaccgata agaaggccgc gcaggacgat 1200
gccgctgtgc aggccgctgt caaggcggtg gccgaggcac tgggcgatac cggccgcatc 1260
cttgtccggg agtccggcac cgagccggta gtccgtgtga tggtggaggc ccctgaccac 1320
gacacctgcc agaagtacgt ttctcaggtg gtggatgtca tcaaggcaca gggctacagc 1380
gtctga 1386
<210> 10
<211> 1272
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1272)
<223> ICBIDGAJ_01852
<400> 10
atgaacatca tatataaaat ctgtagtaaa cttagggaaa aaggttgtat gggtttttta 60
aagacagtaa atacacattt ggtgggagcg ataaataaaa aattatatag agcgtttcaa 120
taccaacgca taaatgaaaa gttgctggtg tttgaaagcg aaggtgattt aacggataat 180
tcgtatgcat tgtatgatta tatgaacaaa aaaggttatt tgaagaagta tcagacagtc 240
tggttggtaa atgatatttc gagtgcacta ggttatgcaa aacgcgaagg gggatttcct 300
aatacaactt tcgttaagaa atttccagaa cacattgatt tgaggtggag caaatcttta 360
gcaacctgca agtatttttt ttatgaccat agtaatgtaa tgcatgactt aaagaaaagg 420
aaacaacaaa ctgttgttta cctgacacat ggatttgctg gttataaagc tgggaaggga 480
ggaacagaaa aagaagaatt tacttatcca gattatgtga tggtaacatg taaattatct 540
gccgaattat atccttcctt tgcgaatttt ggaaaagcga aattcctgac aatgggtatg 600
cccagattgg attatttcgg agacgataat agtacgatta gaaataaaat agagagcgaa 660
tacagattat cacgatacaa gaaggttttt ttgtggatgc cgaccttccg tgaatctaac 720
cacaaggaaa tctcggaaga atatttgagg acagagactc atttgccaat tatagaaaca 780
gaaattattt tggacaagtt taatttgttt ttacaggaac gaagtctttt aatggttctg 840
aaaatccatc cattgcaaaa aaatcttcca gtattccaaa aaaaatactc caatattatc 900
tttttgagag atgagcaact tcacgagata aatgtacagc tgtatcaatt tattgcacta 960
actgatgcac ttatcacaga ttattcatca atttctgcag attatatgtt gctaaatcgg 1020
ccgatgattt ttactttgga tgactatgaa gaatataagg agtcaagagg agagttttta 1080
ccggggaacg caattgatta ctggactggt gcgcatgtat ataatctaaa ggaattttgt 1140
tcggctattg aagaaattga aaaaggcaaa gatccatata agaaggaaag agaaaaactg 1200
atttctatat tttatgaagg aacaaagcgt gattcagcta agaaaatctt aaatttcttt 1260
aggatgatat aa 1272
<210> 11
<211> 10047
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(10047)
<223> ICBIDGAJ_01754
<400> 11
atggcatgga cagcagaaca gatggcccaa aagcgggcca aacttcagaa aaaaaccaat 60
gccgctgctg gtggggcaga acccctcagt cagcgcaaga gcgctgacag ccgcaacccg 120
ttagcccttg gcagtacggg aaactctgtg tcggacaata gcaatccatg gacggcggaa 180
aaaatggccg aaaaacgtgc ggcactgcaa acccagaaac agcagacggg caccgacctg 240
tactccacgg cgctggagga ttaccggaca aggaacaacc tgggctttgc ggatgccatg 300
gacagccgga gcgacgagct gaaccggcag aaggtgacag tgagcccggc ggggaatact 360
ctgggaacgt ggtacggaca gcaggcccag aagctgaaga acagctatgc ggagtacagc 420
cagccggagg cctttgacca ggccaaccag tggtttgacc agcctcggaa tcaggagctt 480
gtgaacaagc tgctggaaaa gaagagcaat tataccagct atgccgagac cggcaccagc 540
agaaacgggg ccagcgccgg ggatggtagc atcgacccct tccgcaccac gggaatcaag 600
gggaaggtgg gcaacaccta cagcacggcg gacctgaaaa agctggggta cacggacacg 660
gagatccggc aggccaggga gtatctggac accatggaag aaatcccgga gtggaagcag 720
ctggcccggc ggacggcaaa cactgtgggc ggcgttgcgg acaccgtggc cgctgccccg 780
ctgatgggtg cggagtacct ggtgcaggcc ggaaagaaca tccggcagag cagcgagaac 840
cggaaagcac tggaagcaga gcttgcccgg aacccccgcg agaagaacct gtatgaccag 900
ctgatggaaa ctgacatgga ctaccagccc aagtacagca ccggcgacct gttgcagcag 960
ggatttaccc ggcaggagat cgaggacatg cgcagccgca ttgccggaac ggaagcaaag 1020
ggtggcatcg acacggagaa gagcgtgggc taccagctgt acaaccgggg ccagcagctg 1080
acgggcgcgg cccagagcgg cctgaccgat gtgcagcgga ccgtgcaggg cgtggcgacc 1140
agcgcggcag agaaccttgc cgtggctgcc atcaatccgg cggcggtgct gccggtgctg 1200
agtgcccagg gcgctgcgga tgccatgggc cagagcgcgg ccaagggcga aagcgcaggc 1260
aaggcgctgg tgggcggcgt ggcaaagttt ggcgcaggat gggccatcaa cagcgtgggt 1320
gcggctgatc tggcaagaac catgggcgcg gactacgcca gaaattccgt ggcgggagct 1380
gtggcagaca agatccgggc gctggctggg gattcggcct ttgcggcggc acatccggcg 1440
gttgccaacg ccatttccgg cggcattgac aacgccgtgc aggcctttgt ggagacctac 1500
gccgacaagg ccattgatgc ggccctggga gacagcgaag ctgcccagac catgtttacc 1560
acggacacgc tggttcaggc gctggaagcg gggctgaccg gcggcgcgtc cggtgcactg 1620
ggcggcgctg tgggcacagg gctttccagg atgaacgcgg gagattccag cctgcggggc 1680
aacgtggagc ggtatgccgc tcaggacgaa tacgagcagg cgctgaagga acaccagcgc 1740
cgggaggagc tggcgcggga accggaaccc ctcagtcagc gcgtgagcgc tgacagcccc 1800
cctaatagtg gggcccttgg catgtcggtg gagtctgatg ggactgaaaa aggctctgct 1860
gacctgaaag cggcgggccc tgcggctgag ggcaacagtg cagaaactgc tgccatatcg 1920
gacaacttgg ctgtgcagac gtttgcagaa gcggcgaccg gtgacagcct gacaggcaag 1980
accatcaggc tgttcacccc ggaggccgga aacgaggcaa accgcgcggc ttttgaggaa 2040
gcctatgggg tggagttgcc gagcacggct gcggctaccc ggcggatgct gcgggaagtg 2100
gcggcacagc gcagccagca gaatgctgtt gagaacgctg gggaaagtgt ggaaagcccc 2160
acggaaacag cggcggacgg cgcagaaccc ttcagtcatc gcataagcgc tgacagtcgc 2220
aacccgttag cccttggcag tgcggaaaac actggtctga ctgcgcagaa tggagctgac 2280
cggcaggctg tgatgcagtc ggtccctgtg gaagaaagca cccttgacgg gatggacagc 2340
agcaacagcc cgatgcggga gacctacggc atggaagcac cgaggacgga aggccagaag 2400
caggcccgga cggagcaggt gctgcggagc tggaaggtgg gcgaaaaggc agcgcaggag 2460
atcagccgga aacagccgga aggcgtggac agtgaccgct atgcggcggc agcatccact 2520
ttgtaccggc tgggccagat ggaggacgtg aagaactttg accaggcgct gaagctggcg 2580
ggcaccggca gcggcatggc ggccaacgtg aactatgtgc tgggcaacct caagggccgg 2640
aacgcgctgg agatcgccta cacctacggc agggatgcgg cagagacccg gtgggccaag 2700
agccagctgg gcggcactct gacggaacag agcctgacgg gcaggggtga gaccatctac 2760
aagggaacca cgcggagtga gaacgacgca ggcagccagg tgatcgagct gaacgcggcg 2820
gcaaccggca ccacggcggt tctgaaaaac gtgctgcaga acggtgcggg acaggcagac 2880
agccgggtgc gggcctatgt ggacacggag acggcacgga tcttctttgg agacagcgca 2940
caggatacgt tcggcacggt gctgcacgag gactaccact ggtacaacgc actggacagc 3000
gagggagcca agaccttgca ggaccatgcc ctgctgtatc tggccaggag cagcggcttt 3060
gagaccgtgg acgagatgat ccgggagaag atgaccgact atgcccagca gaatctgacc 3120
tatgaggaag ctgccgagga gctggtgggc gatgcctggc ggggcatctt ctccaatgaa 3180
tccgatttca agcgctgggt agagttccag cgcgggcagg ccgagaagaa cagcggcagg 3240
gccggaacca tccgcaccgt gatgaaccgg gtgaaggaga tgctggacgg cattgtgagc 3300
cgggccaagg aagtgctgac ccttgacccc gacaaccggg ctgccatgaa ggcccagcgc 3360
ctggccgaga acgagcgcag aattttgcag gacgaatact ttgcccacgc tgaaaaagcg 3420
atggacaacc tgcgcagtgc aaaagaaaac gccgctgccc ccaagacaga gagcgcggcg 3480
gaaggacgca atattcgttt ttcgatccag aaggatgccg acggagagag ctacatcaaa 3540
attgatgaag atatcctgaa cggtgtaccc cgtgaagaat ggaaaactgt ggtgaaacag 3600
gcaatcaagg agcggtatcc gaacggcttt gagcggaacg gctggacaat tttgaaccat 3660
aaagatggaa gaagtgagtt tgtccgttct aaatctacaa tggcgcttca gagaacgaac 3720
gaagaaacgt atgcagataa aatgcggatg gctgcaaatc tggatgaaat tattaaaacc 3780
gcagatgaag tctacagaga acctgcaaac cacaagaatg cggaagcatt caaccgtgga 3840
aaaatcaaaa ttgtggttgg gcagaatgcc tatgaagctg atgttctgac tgccttcaaa 3900
gcaaatgacc gggagatttt ctatgatatt gtagatataa aatctacaaa taataaaacc 3960
tccatgcgta cccacgtaga atccaaagat tcaaggagta gtctgcaagg aggttttacg 4020
gaaccctccg gcaaagccca catggaatcc gaagattcgg ggagcagagg gtcggagggt 4080
tctatttatc aggaaagcgc tgacacggta ctcaaaaccg aggagggcgg tgaacgcccg 4140
agctttcctg ctaaaaacag tatagcacaa gaaaatgccg aaagcaaggg aaacagcgaa 4200
cctgtgaaga aatcagtgcg gttccagctg agtgacggct ctgctggaaa cgtggatgaa 4260
ttggcggcac ttcaaaaaga aagtcgggaa ctggaacacc agcaaaacgc cctgaaaaca 4320
gagcgaacaa actggctgaa cagcgccgag gtaaaggaga ttgaagggaa gagaaaatct 4380
ctgggtttgt tctctgccga ggcaaaggag tttaaggcca gtgaagaata ccaggcgtac 4440
cttgcaaagc ggaaggactt taaccagcgt ggtgcagagc ttgaaaaccg aatcggtgaa 4500
gtgaataatg cactgcggga agcccatgcc aagctggaaa cccagagaaa tgaacagaag 4560
cagaaacagc aggctgtcta tgatgccaaa gcaaaggaag caggcggtgc ggcgaagtat 4620
cgccgtcagc tggccgtgga gcagtttggc acgacgagtg aatttgaacg ggccggatac 4680
atcctgccgg atgggcagat gctggatttt gcccggaatg ataagacccg tgacaccgac 4740
caccgggaaa ttatgagtgt gttcggcccg gcggaagtat cggaagggac ggacgcactg 4800
aacaagttcc tggcagacgg taatgtgcgg gtgatggcgg aagctccggg tgttgacctg 4860
gccgcagaca aagccccgac cgctgcacag atggaacaga tccgtgagat ggtgggaagc 4920
ctgggcagtg aacagagaaa gttcacgctg gatatttcca ccaccgacgg aagggttgca 4980
gccagcaagg agtacagcgg ccgcattgat gctgaccgtg ttgtgcggga gatcagggac 5040
tattacaaga ccggtgagct gcccgcagag agcagcctgg cacgattccg gtaccagctg 5100
gcggccaaag ccgaacaggc ggaacgggac gcgcggaaga acacccagcg gcaggcaagc 5160
cgggccattg cggacaacag cgcggcgatg gaaacgctgg cccagatgat gggtgtgacc 5220
cacggtgtgc ggatcagcca ggattccatt gacgggctgg cggtgcggtg gacaaaggcc 5280
aacggcagca gggccgaccg gacgaaaatt gccggagaga cccgggcgct ggtggagtac 5340
atgacggcgg acggggccag catgagcaag gccagcgcgc tgtctgagac cattgcggat 5400
gagattctga gcggggcgac ctaccggaat accgagctgt gggacgagta cccggaatac 5460
cacgacttga gctacacggt gaacaaggac ggcccggcca aggcggagct ggtgaagcgg 5520
tacgggacgt ggagcgaagc ggtggcggag gcacggcggc acggtgtgaa gctgcggcag 5580
gcagaaggtg tgcgggacgg caacccggcg gaagtgtatg aatccatcgt caacgacacc 5640
cgggccatgg gcggcaccaa ggaaggggca gcggccttgt tccggggcgc ggcccaggcg 5700
gcaggcgtgg acggcgcggc cagcatggag agcaccgagt ggctggatgt gctgatgaac 5760
gtgcacgatg ccatcaagcc caggatgatg agccgctttg cagatgctgc cgagtacgag 5820
gatgccaaag tggagctggc cgaccggatg ctgggtgata tcctgaacgt accggagatg 5880
accgatgcac aggccatctt tgacgggttc cagcgctggc agcgccaggc tgtggctgct 5940
gccgtgggcg aggagaacgc ggagcaggcg ctgaaggacc tgcggaaggt gcagaaggag 6000
cagaaccggg agttcaaccg gaggatgtat gagaacagcc ggaacggaag ccgggatgaa 6060
gcactgcggc agtggacaga acagcagaag cggaatgaaa aagcagaaaa gctgctggat 6120
cagaatctgg atacgctggg gctggacatc accaactacg gcgacatggc cgaaaagctg 6180
gacgtgctga aggaagccta cgaacgggag tggaaggccg aaaaaaagcg gctgaaggaa 6240
gaacgccagc agatgctgga cgagatccgg ctggaaaaca aacagttgaa gcgggagaac 6300
tggaaccttt cgcaccaggt ggcaggagaa cagcgccggg ctgatcgggc tgagtggcag 6360
ctgatccatc aggaaaacga actgctggaa tgggagcagg aaaaccagcg caaagctcag 6420
gagtggcagg aaaagcaggc ggagcgaaac gcaatcgcca tcactgcagc ccagcagcag 6480
cgggacgagg acattgctat tgccaagaag ctggctgaga agcgggtaca gaaagcccgg 6540
gacggtcggc agaaggacga gctgaaacgg gccatccgga acaatgccac ccagctgaac 6600
cagatggtgc tgcggcctgc aaaggacaaa tatgtgcagc cccggctgat cctgcgggcg 6660
ctggaagtgg caaagctggc ggacatgaca ttgctgaacc agaatgccgt gaaccggctg 6720
gatgcgctgg caaacagcat ccgggccgaa tacggggatg cagaccaccc ggtggtgacg 6780
gagatgagca atgactggga gaagagcggt attgccaacc tgatcgatgc cctgaagaac 6840
gacctgagcg acagcaagga ggcacagctg gaccggctgc gcgggcagtt ggccgaggca 6900
gaagcgctgg aggacagcca gaaggcccgg gaactgagaa gccgtctgga agcccggatc 6960
aaagacgttg aaaacaagcc ctatctgccc atgacggtgg accagatgcg gatgctgaaa 7020
gccattacga ccagcaccct gcacgtgatc cggacggcaa acaagaccct gagcctgcag 7080
caggccgagg cggtggacaa gatcgccgga gaagcggcgg tggaagtgaa ccggagcaag 7140
ggaaatgacg gaaaaatccg gcggatgctg acgaggtaca atctggatat gctgggcggc 7200
acccgggtgt tccggatgct gggcggctac gcaaagaaca gccagatgga gaagctgggc 7260
accatgctga acgacggcca gcggcggcag acggagatcc ttgtggaggg aacccacctg 7320
ttcgacaacg tgacaggcaa aaagaacctg aaacagatgg aacagtttgc aggcaagggg 7380
gcaaagctgg tagaccttgg cctgaaggac aaccggggca aggccgcacc cctcacccat 7440
gcccagatgt gcagcctgta catgcacctg cggaacgccg acagcaagga gcacctgatg 7500
aacggcggct ttaccgtgcc ggatgcagtg gagtacaaca aaggcaacat cgcggaagcc 7560
taccagaagg gccagaccgt gcggatcggg atgctgaccg acagcgaggg caaacccatg 7620
gcggacacca ttgtgagtgc aattgaaaag aacctgaccg actacgaccg ggcatggatc 7680
gggagcatgg agaagttttt cggaagctac accaccgacc tgatcaacga gacgagcatg 7740
aagctgctgg gctacaagcg ggccgtggtg aagaactact accccattgc ggtgaaccag 7800
acggcactgg taaaacagat cgaaggagaa cactgtgatg cgaccatcga gggacggggc 7860
ttcctgaaga accgtgtgaa aagtccacag cccatcctgc tggaggagtg caacaacgtg 7920
gtgcagcgga gcctgcggga cacggcagcc tacgcgggcc tggccccggc catccgggat 7980
gtgaaaaagg tgctgaacag ccggatcgag actgaggacg ggctgaaggt gctgaaggac 8040
ggtatcctgg aggagaagtg gggcagcgat gcagtagact atgtggaaga actgctggtt 8100
gacctgcaga gcccgggaaa gaaaacccgg aagagcagca tgacggcgct gggcaagctg 8160
cggggcaact acgccggggc tatcctgacg ctgaacccgg gcgtggcgat tgcgcaggcg 8220
gcatctctgc ccacggcagg cgcggtactg ggtgcggata ccatggcggc ggtggttccc 8280
tttgtaaaga acttctcacc caagcagcgg gcggcgctgg aagcagagat cgctgaacac 8340
ggggatgcgc tgctgcaata ccgccagcgg ggcagccagc ggggcgagct ggaaagcatc 8400
gggaagaacc tgagtgcggc ggagaaggga atggagaagg tccccaagca gctgacgggc 8460
tggatcaacg gcgtggacga gatcacggtg gcggccctgt gggaaggttc caagcggtat 8520
gtggagcacc ataccaatga gtttgcagag ggtgcagcca cgaaaggcag cgaagcctac 8580
tgggaagctg tgaacaagac ctatcagcga gtgatcgagg agacccagcc caactacacc 8640
accatgcagc gggcaggcat ccagcgcagc gacaacgaac tggtgagaac cctgaccatg 8700
ttcacgaccc agcggttcca gaactacggc atcctggcag atgcggtgat ggactacaat 8760
gcccagcggg agcgcagcca tgcagacccc accgaggaga accgggtaga gctgaaacgg 8820
gccgggaaga acctgaaccg agcggtgacc agccagatcg tgcagacggc agtgtttgcg 8880
gccatgaaga tcggcgcgga cttcctgctg caccggtggg accgggaaca ggacgagaac 8940
ggcgacatta ccgcatggag tttactgaag cggtacgccg acctgtatgt gggaagcgca 9000
gcaggcacgt tcctgtacgg cagcgagctg tacagctttg tgggcaacgt ggccgggggc 9060
aaggactatg atgtggtcag tgccccgaac ctgagtgcta tcaatgacct gggaactgag 9120
gcgatgcggc tgtacaagct gctggccact gacaccggcg agatggacga ggaagagctg 9180
gaagcatacc acgagaagct gcggaaagcg gccctgacct ttatggagga cggactggaa 9240
ctgaaggggc tgccggccgg gaatgcggaa aagctgctgg aagcggcatg gaaatggagc 9300
ggaaatgcag cctatgcggt gacgggcgga aagtacggcg agaagctgag cctgaattcc 9360
ctgccagcca gcgccaccgg gcagtatgac cggctgtaca acgccattgc cgagggggac 9420
acggacaacg ccagcggtgc tatggcgaag ctggaagcca tgggcaagga cgaaaagacc 9480
attgccagcc agctgaagaa ccggctgaag aaatacagcc cagaggtgga gcaggctgca 9540
caggcccgga acgagggcaa agacagccag cgccaagagc tgacaaagca gcttgtgcgg 9600
gaaatgtacg agaccctggg catccgggag ggggtcaaag ctgacgcgga aaagcggaca 9660
tgggtgatcg accttgtgac cgaagccatt gaaagcaagg ccgaggagct gtacaagggc 9720
ggcaccgagg gcagcgtgta cgatgacctg actgaagcgg tggacaccgg caggaccagc 9780
gacgtgcagg atgagatccg gcggctgcgg acggcgggca aggaggacgg cagcatcaag 9840
acgaagatca ccgacgcggt gaaagaggag tatctggcgg gcaacgacca cgaccgggag 9900
aagctggaga agctgctgct gaagctggaa aaggccgacg gcagccagat gtacgaggag 9960
aagaactttg cccagtgggt gaaggacgcg gcaaagaagg aggaacaggc aaagaacagc 10020
aaggatgagt gggcaggggt gaggtga 10047
<210> 12
<211> 1659
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1659)
<223> ICBIDGAJ_02242
<400> 12
atgaaaaaga tgatctctcg ccgcaatttc ctgaaggttt gcgccgttgc cggttctgcc 60
gtggcactgt ctgcctgcgg cggcagcaaa aaggccgctg gaccggaccc ctccaacacc 120
gaccagacca gctttgacat cgtgggcggt cagtctgccc tgagccccgg ctacaacgac 180
aacgaggtgc tgaagaagct ggcagataac gtgggcgtta aactcaacta cgagaccatg 240
agcgactccc tcagcgagca ggtgaacatc cgcattgcag gcgaccagct gccggatgcc 300
tttatgggtg tgggcttctc caactacgat atcgccaact acggtgcaga cggcaccttc 360
ctggacctga ccccctatat caacgccgag atcatgccca acctgaccaa gatcctggac 420
gagcacccca acatccgcgc cgctatcacc atgagcgacg gctgcatcta cggtctgccc 480
gctgccgagc agatgggcac tgccggtatc ggtgacgacg aggattacag catcttcacc 540
attccgcagt tctccatgat caacaagcgc tggctggacg agctgggtct ggaagtgcct 600
accacgctgg atgagctgca caccgccctg aaggctttca aggacaacga tatgtctgcc 660
aaggtctacg gtaatgcacc cggcagcacc atccccatgt ccactggctt tgacgagtgg 720
tgctggggtc agaacatctt ctacgcaggc ttcggattca ccaactggcc caacgatgtg 780
tgcaacgatc tggtgctgca gaaggacggc aagtgccgct ttgtctgcgc cgaggacaac 840
taccgcaagg cggtcaccta cttccacgac tggtacgccg agggtctgat ggacgtggag 900
atgttcagtc aggataccaa ccagctgctg gctaagggcg cacagggcta tctgggcgtt 960
tccacctggt ggtacatcga ggagctgatg ggcgattact ccaaggacta tgtgttcctg 1020
cccgtactgg acggcccgga cggcacccac aacgtcaccg tgcgtaccgg cggcggtacc 1080
aacagcggca acctgaacgt gaccaacaag tgccagagcc ctgccaacct gctgaagttc 1140
tttgaccagt ggtatgacgg cgagaccgtg atgcagctgc agtacggccc cattggcgtg 1200
ttcttcaccg agcaggatgc caacggcaag tggaaatcta tcaccgagga agaggccaag 1260
gcaaagtaca acaagggtgc cggtgagctg aaatccacct acgaggtctg gggtcccaag 1320
ctgatcctca gcgagtacta cgacaagtac ttctacatgg aggaccgcgc catcgagcgt 1380
ctgaccgacc tgaaggactt ctggatgccc tttgtggacg acaccaccac ctaccccatc 1440
gactgcgtgt tcaccagcga ggaactggac actatcgacc gctaccgtgc tgattttgag 1500
aacgcagtct ctgaacagga aggtctgtgg ctgaaggatg gcggcccctc tgatgacgag 1560
tggagcgcat acctcgacac cctgaccaac agctgcggca tggacaagct gctggaagtc 1620
taccagaacg cttatgaccg ctacaaggcc aacgtctga 1659
<210> 13
<211> 1341
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1341)
<223> ICBIDGAJ_02225
<400> 13
atgatgctgt gcgtcatatc ctactgggta ttatctggcg caaaacggcg gcagatccag 60
cagcttcgct gctgcgttct ccccaccaag ctgttgaaac ggagggatgt ctatctgaaa 120
ttaacacgac acaacggacg agccgggacc cacggcacct ataaccccaa gcacaatgac 180
cgaagtttca accttgccaa cagtgagcac atcgacccgg aacgagccaa gggcaacatc 240
tactgggact gcttccacgg cttccgttcg gctctcgatc cgcaagacct ggacgatctg 300
gcagcgacct tctcggaggt agaacagcaa ttctacgaga accgctattc ggagttcatc 360
gaaaagcaga acgagcgcaa tgccgagatc cggcaaacgg aacgcaaccg ctccattcct 420
gacctgctgt ccagccgcaa gacctgcccg gaagaaacca tctatcagct tggaacaaag 480
gacgaccatg cttcgggcga agttctgctg gcggtcgtga cggagtttat tgaagagttc 540
aaggcgaggt tcggagacca tgttcatgta ctggactggg cgttgcatct ggatgaaagt 600
acaccgcata tccacgaacg tcatgtgttc gactgcgaga acaagcacgg agaggtcgca 660
ccccagcagg aaaaggcgct ggaagcgctg ggcttcgacc tgcccgaccc ggacaagcca 720
ctcagccgcc gcaataaccg caagatcacc tttgatgcag cctgccggaa gatgctgttc 780
gagattgcca agcggcatgg gctggatctg gaggaagaag cggagtacgg caaccgcaag 840
tatctggaaa agcaggattt tgtccttgcc aagcaaaagg agcagcttgc cgcccagcag 900
gacaggctgg acgagctgac cttgaaagtt tcggatatgg agacccttct ggatgatgtt 960
tcggcagcag cctatgacaa ggcggtggag gtcgtgaccg atgtggtgcg caccgagacc 1020
cggaaggaag atatgcggat gatcgaggac acgaagaagt gggtgctgtc cccggaacgt 1080
aaggctccgc agaccacgag agaatacgcc gcccaccgtt tggacaccgt gctggacaag 1140
ttcctcaaga ccatgcagac caccaccgca cgtctgcagg agaagctcct gaagccggaa 1200
gtccggcaga aaggcaagga gcaggtcaag gagaaagcac gagattccgt tctgcagttg 1260
ctgaaccgct tgcaggcgga acaggcacaa aacaaactaa cggcacaacc cagcacacag 1320
gaggggcact cggaaatctg a 1341
<210> 14
<211> 948
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(948)
<223> ICBIDGAJ_02240
<400> 14
atgacgcaga cctcgccagc tgctgcacgt cagctggacg ctatcccggt ccaccgcaaa 60
agcctcagcc aacggctgcg ggaaaactgg cagctctatg tgatgctgct gatcccggtg 120
gtgctgacca tcgtttataa gtactggccc atgtacggca ttcagattgc cttccgcgat 180
ttcaaggcaa gccgcggcat caccggcagc gagtgggtcg gcctgtactg gtttgaacgg 240
ttcttcaccg cacccaactg tgtgcgcatg atcaagaata ccgtgctgct gagcctgtac 300
agcctgctgt ggagtttccc catccccatc atcctgtccc tgtgcatcaa ccagctgcgc 360
tttgcaaagt tcaagcgggt ggtgcagacg gtgctgtatg caccccactt catctccacc 420
atggtcatct gtggtatgat caagatcttc ctcagtccgt ccggcggtct gctgaacctg 480
atcctgggca ccagcgtgga cttcctctcg gagagcgccg cattccgtac catctatgtg 540
gcatccggca tctggcagga agctggctgg ggcaccatca tctatatggc ttgtctggct 600
gctgtggata ccagcctgta cgaagccgcc aagatcgacg gtgcatccat gttccagcgc 660
attctgcaca ttgatatccc ggaactggta cccatgatcg tgctgcagct cattatgagc 720
gtaggcaacc tgatgaacgt gggctttgaa aaggtgctgc tgctgcagac cgagctgaac 780
aaggccacca gcgatatcat tgccgtgtac gtctacgaac agggcatcat caacgccaag 840
tacagctatt ccaccgctgt gggtctgttc aacacggtgg tcaacatcat cctgctcatc 900
atcgtcaacc gcatcgccaa gaaggcggca gacgtcagct ttgtgtaa 948
<210> 15
<211> 366
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(366)
<223> ICBIDGAJ_00328
<400> 15
atgaaagaga ttacacgtcg aaacttcttg agaatggcca caattgcagt gctcataagt 60
ggaatgggaa tgttgtcgag ttgcggaaaa agtaaagaag agctgatgag tggggattgg 120
tatctccaag gagatgatcg actgtccctt tcgctttatg atgatggtac ttgtcagatt 180
caaggagact acggacaggg aaaatggagc attgtagatg aagatacctt gaaacttaca 240
gatttctatg gagaaacaag aacctatcct attacagctg tcgatgataa ttcgcttgaa 300
cttgagttgc ccaatggtga aactgtcaca tattatcata cggctgaaga agcgttaaaa 360
cattaa 366
<210> 16
<211> 1008
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1008)
<223> ICBIDGAJ_02239
<400> 16
atggcaaaac agaacaccgc ccctactatg aaggatgtgg ccaaggaggc aggagtctct 60
ctgggcactg tatccaaggt catcaacggc atcccggtgg gcgaggaata ccgcaaaaag 120
gtggagcagg ccatcaagga actggactac cacctgaacg cctatgcgcg cggcctgaaa 180
agcaaccgca ccaataccat cgccgtcatc ctgcccacca tcgcacatcc ctatttcggc 240
ctgatcgctc attgcatcaa cagctcgctg caaaagcgcg gctaccggat gctgctctgc 300
gataccgact atgacaatga aaaagagcag gaaatgatcc gcatggccga gcagaacaag 360
gtggacggca tcattgccct gacctatgac ccgaagctgg aagtaccctc ggagatcaac 420
tccgtctcca tcgaccggta tctcggcgcc aacatcccct gcgtggcatc agataactac 480
gcaggcgggc ggctggccgc cgaaaagctg atggaaaacg gctgcaggaa gctcgccttc 540
ctgcgcgtcg gttccagcat cgtgggcgag accaacaaac gcaaggacgg ctttgtggcc 600
gcctgtgaag ccgcaggcgt tccttatgaa ataaagaatc tggaagatgc gcgggacggc 660
atcgtctttg accccatggc cgagttcgcg gtgttcctgg acgatcatct gcaggacggc 720
gtgttggagt ttgacggcat cttctgcgtg accgaccgtc tggcctacca gattgttcag 780
ctgctgcgtc tcatggggct tcgggtgccc gaggacgtgc aggtcatcgg ctttgacggg 840
ctgcgcacct tcggcgacat ggattattac tgttccacca tcgttcagcc cgtggacgcc 900
atcgcagaga cctgcgtgga agtcgtgctg aacgagaacc gcgccaatac cccctccctg 960
ctgtgcctgc cggtcagcta tgcttacggc ggcaccacca aggcatga 1008
<210> 17
<211> 312
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(312)
<223> ICBIDGAJ_00394
<400> 17
atgaacaaat ctcggcctgt tgcgaccgaa actgtgaaat ctttgaatta tacgaaaaat 60
atcttgcaga ccattccgaa taacgataaa atggaagtgg tcactcaaac caatgccgtc 120
aagtctccga ctgacagcct gaaagccaca acactggtgt acacggtgga ggaaattgcg 180
cagatgctgt ccatcagcct gcgctctgcc tacaacctgt gcaacagcac taccgaattt 240
cgtgttcttc gggtcggcgg aagcatccgc atcccgaaag acagtttcga tgcgtggctc 300
cgggcagctt ga 312
<210> 18
<211> 699
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(699)
<223> ICBIDGAJ_02238
<400> 18
atgaccgccc cggaaaaagg ccggtggtac tggttcaaaa actggctgca ttaccactgg 60
ctctacctta ttattgtggc tgtggtgctt tgggtcggca tcagctggct gggcaacgcc 120
ctgcactggg gcgagacact gccggactac cagatcgcct atgtgggcaa aagttctctg 180
ccggaggaca ccgcccacgc cattgaagca gcctttgcgc agtacggcga agatctgaac 240
ggcgacggaa tcgtttcggt caagctcaac cagtatgtca gcgacactga ggacatggaa 300
aacgcttcta cttacgcgct tgcggcgcag atgcagtttc tttccgatat gaacgccgag 360
gaaagctatt ttctgctgct ggatgacccg gcgcattttc aactggacta tcaggcactg 420
gcaaactggg acggcacccc gccgggcgac aacgactata ccgccaccgg aaagaccgtg 480
ccttgggcag actgcccggt gctggccgga tacgaccttg gaacgtatca gaccaccgtg 540
ttgggaacca ccgttactgg cagcagcgca gaactggtaa acggattatt tttaggccgc 600
agggcctttt atgaagagcc cacgaacgaa aaagccgctc atgcccggga aggagcacag 660
cggctatgga agattctgac ggaaggagca actccatga 699
<210> 19
<211> 1386
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1386)
<223> ICBIDGAJ_00393
<400> 19
atggcatata ttacgaaacg cggcagctcc tatggtgtcc gctatactta tcaagacgag 60
cagggtaaaa actgcaacaa atgggaaagt ttttccacaa aagaggaggc aacaaatcgc 120
aaaaaacaga tcgaacacga acttgcaaac ggaacgtttc tgattccgtc caccatcacc 180
gtcaaagagt ttttgatgga gtggcttccc aagcaatgca acaagcacaa atgggcacct 240
tgcacctatc aatccaatct gggaacggtc cagaacctca tcattccgta tatcggcgat 300
atgcagatgc aaaagctcaa accctaccat ctggaagatt tgtattctac cctcagcaaa 360
acgccttgcg gccaatatct tgagggcaaa aagcaggtgc tttcggaaaa acagcagcag 420
cggcttctct ctggaacaac catccacgag gtgcaccgcc tgctgcggac ggcgtttcag 480
tatgcggtgg agtggggcat cctcatcaaa agccccgttc cggtggacag ccctaaaaag 540
tcgattcagg agcgtgccat ctgggacgcg gacgagatgt gggccgcact tgccagcatg 600
gaggacccga ttctgcatct ggcagttcat ctgacgctgg tgggtgcact gcgtgaggga 660
gaagtcgctg gtctgacccc ggaagatctt gattttgagg gagcggacgg caccggcaca 720
ttccgcatca acaagtgtat gcagcgcgtc cagaaggcat cgctggcaaa aacaggcaag 780
gactgcatcc tgcaggaatt tgaggataag cgtgagggca gtaccacaac gctggtgctc 840
aaaaagacca aaacagcatc ttccatccga accattttca tgacgacagt gttgaaagag 900
gaattgaagc actggctaag gcgtttggaa atggacgaag ctgttgaccc ggaacgctac 960
cgcaacagtg ggatgctcct gcgcttgccc aatggtctgg cggtggagcc gatcctcatc 1020
cgcaagaagt tcatcaagtg gcaggacgag cacccggagt tcacccgcat tgtgtttcac 1080
ggtctgcggc attccagtgc cacctatcaa ctgatgatct ccggcggcga tgtgaaagcg 1140
gtacagggca caacgggcca tgccagcgct aatcttctgg ttaacaccta tgcacacatc 1200
cagcaggatt cccgcaaaaa gctgggcaaa aagttcgagg aaggcttcta caagccggga 1260
gcaacacctg tgcaggctgc cccggttgaa gcagaaccga ccgtctccgt gtcggcactg 1320
ttggagcttc tgaaggacgc agacccctct gtaaaagcgc agctccgctt ggctttgctg 1380
acctga 1386
<210> 20
<211> 195
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(195)
<223> ICBIDGAJ_01337
<400> 20
atgagtgcta tggaccttga gcgcgaggtc atccgtatgg gcgatgtcgg tgtcgctatc 60
gacatggtag acagcaacct tgcggatggc aagctggagc aggctgaacg tgccgttgtg 120
attctccggg aaatcttcaa agcccgcaat gacgggctgc ggaacagctt ctacggaggt 180
gggcggaatg cgtga 195
<210> 21
<211> 621
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(621)
<223> ICBIDGAJ_02237
<400> 21
atggaagatt ctgacggaag gagcaactcc atgaaacgga aatggttgtg tgttgtagca 60
ctggcgctgg cggcagtgct ctgtaccggc tgcggtgtga aggatgaaga tttgaaaagc 120
gacccgctgg taaatgcgga tggcaccgcc ccggtgggca aaacactggt tgcccctgct 180
ccgccggagg gctttaccct gctggacaac aaagacatcc ttgcagccaa cggtctgtac 240
tatgcttcct gggtcagcgg agccccccag ccctacgaaa acagcgaggg gaaaaccgta 300
gacctctacg atgcccagct cacgcttgtc gtgcaggaaa acaagacgga ggacaaagcc 360
gcctctgcgg tagagggctg gcagacgctg gcacagcaga actacgatat ttccgacaca 420
cagaccctga ctgccgccgg gcaggaatat acggtcattc agttcaccta tcaggatgaa 480
agcaatccgt atgcgtccgg cgttgcggcc ttcgcacagc gcggcacaag tgcaatcgag 540
tgggaacttt cctgtcagga cagctattcc ggcgatgcgc tgaaagtcct gaccgatttt 600
ctgaacagct gtacttatta a 621
<210> 22
<211> 777
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(777)
<223> ICBIDGAJ_02236
<400> 22
atgggactgt tttttccgag tgaccccatc gtccacggcc agcgcgctaa gggtctgccc 60
cgttatcagg agcttctgga acgcgactgg aaaagtttcc tcttcgccga cttcgtgacg 120
ctgggcctgt gcatcccgta tggtctgggc gtgggctacg cgctgctttc ttccagccta 180
ctggtgctgc tcccggtctg cattctgggc gggcttctgg tcggcccggc gatctccggc 240
atgatggatg cgttgttccg cagctaccgg gatgcacccc gcggctggtg ggagaattac 300
tgcaaagcca tgcgccagaa ctggaaagcc tccctcctgc ccggcatcgt attctgcctt 360
gcgctgggca tcgagctgtt cttcggcatg gtgctgttct ctgcggaaca gctgccgggc 420
atcgggacac tggccgtttt ctttgtcgga ctgctgttgc tgctgatgct gttcaccgcc 480
ttttggccgc aagtcgtcct gtttgaggaa agcaacctgc accgactgca aaacgctatc 540
ctgttctgcc tgaaatatgg caagcatgtg atcggcacgg cgatcctgca actgggctgg 600
tggcttctgt tcgtgttgtt tttgccgtgg acgggctttc tggtgccgtt cctcggtgtg 660
tggtttatct ggttcgtctg cttcttcctg ctgtattccg attttgatgc cgcgtatggc 720
attgaggaaa agatccggca gcagttcccg gagcagacac cccgctacga tgaatga 777
<210> 23
<211> 90
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(90)
<223> ICBIDGAJ_01867
<400> 23
atgaaggtcg catacgtccg cgtcagcacc gaagaacaga acgaggctcg ccagatcgaa 60
gcgctcaaga agcacagcac cgagaagtga 90
<210> 24
<211> 396
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(396)
<223> ICBIDGAJ_02197
<400> 24
atgccaagaa cgaagaaaaa agtgaaatct atcgtaaaga caaaagtaat ctccgcgcga 60
gttaccgaag tagtacatga acttttacac cagcaggccg aagatgccgg aatgacgctc 120
tctgaatttg cagcgcagat gctgatgaaa ggtcgcgtga atacctcgta tgtattctat 180
gtccacccgg acgagatcga agccatcaca cgggagtttt ccgccatcgg gaacaacctg 240
aaccagatcg cggcgttctt caacagcggc ggtatccagt cgcgcgctat gctcgaaaac 300
atcaaccatg cgatttcctg cgtttttgaa atgcgggagc aggtcgcaga aatggcagga 360
aagaactatg gcaatattaa agcacatcgc aagtaa 396
<210> 25
<211> 426
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(426)
<223> ICBIDGAJ_01749
<400> 25
atgaaaaatg agatttgtgc ggccatcggc attgtgggcg gggccattgc cagcctgctg 60
ggcggctggg acacggcgct gcagacgctt atcatcttta tggcaatcga ctacatcact 120
ggcctgatcg tggcgggggt gttccacacc agtcccaaga ccaaaactgg cacccttgag 180
agccgggcag gctggaaggg cctgtgccgc aagggtgtga gcctgctggt ggtactggtg 240
gcctgcaggc tggatgctgt catcgggtcg aactttattc gggacaccgt tgtcattgcg 300
tttgtatgca atgagactat cagtatcgtg gagaatgccg gactgatggg tgtgcccatc 360
ccggcggcgc tgactcgtgc tgtggacgtg ctgaagcagc gggcggaaga aaagaacggc 420
agctga 426
<210> 26
<211> 1662
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1662)
<223> ICBIDGAJ_02198
<400> 26
atggcaatat taaagcacat cgcaagtaag agttccgatt atggtgctgc actggagtat 60
ctgattttca agcatgacga gcttcggaaa actccgatcc ttgaccagag cggaaatcgc 120
atcatgcggg atgagtttta tctggacggc ctgaactgtg aaccctattc cttcgatgcg 180
gcctgccagc aactgaaccg cgaatatcag aagaacaaaa acaaggatga aattaaatcg 240
cacctttaca tcatcagctt tgatccacgg gacagcacag aaaattgctt gacggggaaa 300
cgggcgcagg agcttggact ggaatatgca aaagctaatt ttccggggca tcaggctttg 360
gtctgtacgc acatggacgg tcataatggc agcggcaaca ttcatgtgca tatcgtaatc 420
aacagtttgc gaaagctgga tgtacctaag cagcccttta tggagcaatc cattgactgc 480
aaggcagggt acaagcacca cgtgacgaac gagtatctaa agcacttgca gaaatccctc 540
atggatttgt gcaaccgtga atttctgcat caagtcgatt tgctgtcacc atccagaacg 600
ggtgtgaccg aagcagagta ttgggcacag cggtggctgg atgagaaaaa acaggaaatc 660
gaaaaggaag ggtttacgcc caacccgaca aaatttcaaa cacagaaaca acttatccgg 720
gatgctgttg ccgctgctcg tgagaaagca atctcgtatg aagattttca aagcatcctg 780
cagaatgaat ataatatttt tgtcaaaaca caacgtggtc gttatagcta tctgccgccg 840
gaacggaaca agttcatatc ggagcgttct ctgggagaaa gcagcaaaag agaatgtctg 900
gaaggattct ttgttcagaa cgccgagaag aatctgcggt acaaggaaga tcccatactg 960
atctttacga ccagaaccag gctgcggctt gttgtggacc tgcaggagaa tgtcaaggca 1020
caggaaaatc tggcctatgc gctaaaggtc aaaatcagca atttgcagaa gatggccgaa 1080
acgctggtat gggtacagga gaacaacatc aacgacctga cggaattgaa cgatctgtgt 1140
aagacagcac aggccaatgc gcaggctgcg tatgatcggc tgtcacagac agaggatgaa 1200
ctgtacaaaa ccaatgagca gattcattat gcgggacagt acctttctac aaaagaggtc 1260
cagcagcaat ttgcgaaggc attttttaag aaaaaattcc gtgcagagca ttccaaggaa 1320
ttggacgcct atgcagaatc cgtgaaatat ttctgggaag aaaacgatgg aaagctgcca 1380
tcgctgaaat ccttgaaaaa acggaaagaa gaactgacca aagaaatcgc ggagaggaaa 1440
aaggcatacg ctcccctgag agaagaatcc cggcgtctgg aaattgcatc ggataacgtg 1500
tacagcatct tccgaaaaac cgatgaaatg aaatccgacc ttgcatggaa acgcgagtgg 1560
gcggcaaaag tccgcgaaaa ggcaaggcag gagcaggttc gacaggaaca gcgcgtacgt 1620
caaccgaaac gtaagaagcg tagctacgat atgagcctgt aa 1662
<210> 27
<211> 915
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(915)
<223> ICBIDGAJ_02241
<400> 27
atggcaaaaa acattgcagc atcccgtcaa aagaagcccg gcggtctgtc cgataaggtc 60
agcgacatcg ttctggtggt catctgcgcc gccgtcatgc tcatcgtggc ctacccgctg 120
tactacgttc tggtggcatc cttctcagac ccctatgacg tttacgccgg caagaccttc 180
ctgcttccca gccagttcac cttgaaaggc tatcaggctg tgtttgcaga cagcgcgctg 240
ttctccggtt ttatcaacag catcaaatac accgtcatcg gcacgattta ttcggtggtc 300
atgatctatc tggtggcata tccgctgagc gtcaaagacc tacccggacg caaatacatc 360
agtctgttct tcgtcatcac catgtacttc ggcggcggtc tggtgcctac ttacctcatc 420
gtcaagcaga ccggtctgct gggcagtatg tgggcgctgt tcctgcccgg tgtcgtggcg 480
gtcggcaatg tcatcatcgt ccgcaacttc tttgagaaca acattccccg tgagctgctg 540
gaagctgccg agatcgacgg cgcatccaaa tggacggtgt tcgtcaaaat ggtcattccc 600
ctgagccgtt ccatcatggc agttatggtg gtgtacagca tggtggccta ctggaacgac 660
tggttcaccg ctctgatcta cctgagagcc gatcaggctc cgctgccgct ggtgctgcgc 720
aatatcctga tcaagagctc caccagtgcc agccaatcct ccatggtagc gggcggcttt 780
gcagaactga ataagctgac cgaaatgatc aagtttgctt ccatcatcgt ggcagctgcc 840
cccatgctga tcgtttaccc ctttgtacag aagtattttg aaaaaggctt catggcaggt 900
gccgtgaaag gctaa 915
<210> 28
<211> 1146
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1146)
<223> ICBIDGAJ_00537
<400> 28
atgaaaatca cagatgtaaa gcttcgcttt gcaaagcatt atctctttgt tcaggtctac 60
accgatgccg gtatcgtagg tctgggtgaa gcgggcaact ggggctatct gcaggcaact 120
gcagcggcca ttgaaaaatt cgcggactac ctgatcggga aagacccctt ccgcatcgag 180
gacttcaacc agaacttcct gcgttcggtc tatttccgtg gttcggtcat tatgagcgcg 240
atctctgcca tcgacattgc gctgtgggac atcaagggca aggctctgag cgtccccgtc 300
tacgagctgc tgggcggcaa gacccgtgac aaggtgcggg tctacgcctc ggtgatgcac 360
atcaccgagg acaagaacga gctggcggct cagtatcagc agctgcagca gatgggcttt 420
accgcagcaa agatcttctg caacggcccc acaagctctt cggacggcaa gggcgagttc 480
ttctccagcc ggatcgagcg ggaagtggaa aaggtgcgtg tctgccgtga agcggtcggc 540
ccggattttg atttcattct ggaagtccac cgcggcatga ccctgccgga ggcagtcgct 600
ttcggccgcg ccgtcgagcc ttaccgcccg atggttctgg aagatcccgt tccgcccgac 660
aatgtggata ccatggccga ggtcgcaagc aagatcgggg tgccgatcgc caccggcgag 720
cgcgccatcg acctgcggga gtgcgaagtc ctgatgtccc gtcacgcctg ccagtatatc 780
cgccccgatg tatgcgctgt gggcggcatt accaccagca agaagatcgc tgcgctggcg 840
gaagcgcacg atgttctggt gatcccgcac aatccgcttg gcccggtctc gacggccgcc 900
tgcctgcaga tctgtgcttc catcccgaat ctgggcattc aggagcttcc cggcttctgc 960
ctgaacggtg cagaggacaa gatggtaaag gagccgctgc gctatgagaa cggctgtatg 1020
ctcatccccg acgctcccgg catcggtgtg gaactggcag atgacgccga ggaactttac 1080
ccggcaaaag aacgtggcag caatgctgcc cgccgtgcat ttgatggtgc ggtgaaagac 1140
tggtaa 1146
<210> 29
<211> 4659
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(4659)
<223> BLCPAMOF_01430
<400> 29
atggccaagg cgcagggact ggccgagacg ctggcgggcg aggtactgga tgaggccacc 60
taccggaaca cggagctgtg gaaccagtac cccgacctgc atgacctgac ctacacggta 120
gacaagaacg gcaaggccaa ggccgagctt gtgaagcggt acggaagctg gacagaggcg 180
gtcgccgagg cccggcgcca cggcgtgaag ctgcggcagg cagagggata ccgggacggc 240
aacccggcgg aacagtacga ggccatcgtg aacgacaccc gggccgtggg cggcgtgaag 300
gagagcgcgg cagcactctt ccgctcggcg gcacaggaag cgggcgtggc gggcgcagcc 360
agcatggaga gcacggaatg gctcgacgtg ctgatgaacg tacacgacac catcaagccc 420
cggatgatga gccggtttgc ggacgctgcc gaatacgagg acgcaaaggt ggaactggcg 480
ggccggatga tcggcgacat catgagccac ccggagatga ccgacgccga ggcggtgttc 540
gagggtatct taaagcataa ccgggaggtg gccgccatgg ctgccggaaa cgaggagcgg 600
gcggctgagg tgacgaaggg actgaagagc gtgcagcagg cccagcggaa ggcttttgcc 660
gaccggatgc gggccaacag ccgcagccag agcgacgagg tcaagagtgt gagccgggcg 720
gagcagcagc tcaacgagaa tctggaaacg ctgggcgcac aggtgagcac ggcggcgggc 780
ctcgacgaga agctgaccgc cctgcgggaa gcctacgacc gggaatggaa ggccgagaaa 840
aaacggatga agctggcccg gcaggagatg ctggatgaga taaagctgga gcggcagcag 900
ctgcgctcgc agatcaacga cctttcccgg caggtggccg gagagcagca gagagccgac 960
cgggcggaac ggcagctcat cttccaggag aacgacattc tggaatggga acaggagaac 1020
cagcggaagg ccgaagcctg gcagcaggaa caggccaagc ggaatgccat tgccatcgag 1080
gcggcgcgcc agcagcggga cgaagacatt gccgtggcca aggcgctggc cgaaaagcgg 1140
gtgcagaaag cccgggacgc ccggaaggcg gacgaactga aacggagcat ccggaacaat 1200
gccgcccagc tcaaccagat ggtgctgcga ccgaagcccg ggaaatatgt gcagaagagc 1260
ctcatcgtgc aggccgctga ggtggcgaag ctggcagaca cggcagtgct gaacaacaac 1320
gccctgacca agctgaccgc cttgcaggac agcatccggc gcagtggaga gatggacgtc 1380
agcatccacg ccgactggga gaacagcggc gtggaaaacc tcatccagac actgcgggac 1440
gacatgaacg ccagcaagca ggcaaagctc gaccggctgc ggcagcagct ggaagaagcc 1500
aaggccctgc cggacggcga caaggccgaa cagctgcggg accggctgcg ccagcgcatc 1560
cgggagacgg agaaccgcac ctatctgccc atgacggtag atcagctgcg gatgctgaag 1620
tccattacgg ccagcacact gcacatcatc cggaccgaga acaagaccct gagccttgcg 1680
agggcagaag aggtggacgg catggccatg aaggccgccc gcgaggtgct gaactcggag 1740
ggcaacggct tcggagagaa attcgaaaag gcgaagggcg cgatgaaccg ctaccagctg 1800
gacatgctgg gcggcacgag aatgttccgg cgcctgggcg gctacaccaa aaacggccag 1860
atggagaagc tggggcagat gctgaacgac ggccagcggc ggcagacgga gatcctggta 1920
gaaggcgaaa gcctgtttgc caacgtgacc ggcaaggaac acctgaaaga ggtggaagct 1980
tttgccgggc cgggggcgga gctggtggac atcggattga aggacagcaa gggcaatgcc 2040
gtgccgctga accacgcaca gctgtgcagc ctgtacatgc tgctgcgcaa cgaggacagc 2100
cgccaccacc tgatgaccgg tggactgacc ctgccggacg ctgcccagta cgccaagggc 2160
aacatcgaga gagcctacca gcgcagccag accgtgatgc tggggacgct ggtgaacgcc 2220
gatggtgtcc cgatggccga caccattttg cagacggtac aggacgccat gacggactat 2280
gaccgaaact ggtgcaagga catggaggac tttttcgggc ggtacaccac gaacctcatc 2340
aacgagacca gcatgaagct gctgggctac gaccgggcca ccgtgaagaa ctactacccc 2400
atcgcggtag accggagcac gctggcgacg gagattgagg gcgtgaagat ggatgccacc 2460
atcgagggca ggggcttttt gaaggagcgc gtgaagagtg acaagcccat tttgctggaa 2520
gagtgccaga acgtggtaaa gcggagcctg cgggacacgg cagcctatgc gggccttgcg 2580
gcccccatcc gggacgtgca gcgggtgctg aacagcaccg tggagacggc agagggcatc 2640
ggtgtgctga aggacaagat catcggcgag aagtggggaa aggagacggt aaactacatc 2700
aacgacctgc tgaccgacct gcagaccacg cggcgcaagc gcagcagcac catgagccgg 2760
gcgctcgacc ggatgcgggg caactacgcc ggggccatcc tgaccgtgaa cccgggcgtg 2820
gccatcgcgc aggcggccag tctgcccacg gcgggcgctg tgctgggagc agacaccatg 2880
gcggcggtgc tgcccttcgt gaagaatttc tcgggcaagc agcgggccgc ggtggaagca 2940
gagatacgcc agcacggcga cgccctgctg caataccgcc tgcgcggcac caagcgggga 3000
gagatgagct ccatcggcgc gcacaaaaac cttgtggcca aagcgtcgga agccatgcct 3060
gctgtgaccg gctggatcac cggcatggac gagatcacgg tggcggcgct gtgggagggc 3120
gcgaagcggt atgtggagca ccatacggca gaattcagcg agggtgccgc ggagaagggc 3180
agcgaagcct actgggaagc cgtgaacaag atgtaccagc gggtcatcga ggagacgcag 3240
cccaactaca ccaccatgca acgggcgggc atccagcgca gcgacaacga gtttgtaaag 3300
acgctgacca tgtttaccac ccagcgattc cagaactacg gcatcctggc cgacgccgtg 3360
ggcgactaca aggctcagaa ggcgcggtac gctgccgacc agagcgcgga aaacaaagcc 3420
gaggtacagc gggccggaca gggcctgcgc caggcggcgg caagccaggt cgtgcagacg 3480
gcggtgtttg ccctcatgaa gatcggcgcg gactttttgc tccaccggtg ggacaaggag 3540
caggacgaga acggcgacat cacggcggcc agcgtgggca agcggttttt cgacctgtac 3600
actgaaagtg cggccggaaa ctttttgtac ggctcggaga tctacagcgc cctgaccaac 3660
gcccgggacg gcaaggacta tgacgtggtg agcgccacca acatcagcgc ggtgaacgac 3720
ctgtttgctg cctttaccaa gaccgtcaag ctgctgcgga cggacactgg cgagatgagc 3780
gaggaagagc tgacagcaca ccaccagaag ctgaacaagg cggtgctgaa ggacatccag 3840
tgcggccttg aactctacgg cgtcccggcg gcgaacatcc ggaaggtgat gcaggcgttt 3900
gaaggctact gggaggatgc acaggccatc ggcagaggcg aagggtttag ctttaactct 3960
gcaccctctt cggccaccgg gcagtacgac cggctgtaca acgccatcca gagcggggac 4020
agcgaggagg ctgcggcggc gatgaagaaa ctggaacaga tgaataagac ggacaaggtg 4080
gacggcgagc tggcaaggcg gctgaagcag tacgacgccg acgtgctggc ggcggccaag 4140
gcccggaacg ccgggaaggc ccgggccgag gaaaaggccc gaaaggccgt atttgagaag 4200
ctgcgggagg ggctggacgt cgcccctgtg acagacaggg ccaagggcaa aacggacgcg 4260
gcccggcggg cgcagctcat cgaccttgtg aacaaggcgg tggacggcaa ggcagacgaa 4320
ctgctggcgg gcagcaagga cggcagcata tacgacgcgc tcctggacga agtgaaaaat 4380
ggccgggcgg aggacgtgca gacggagatc aaccggctgc tgacggcagg caagaagaaa 4440
agcagcatca aggacaagat caccgaggcc gtgaaggagg agtatctggc gggcagcgac 4500
cgggaccggg agaagctgga gaagaagctg ctggccctcg aggacgcaga cgaaaacccg 4560
ctgtacgagg aaaagaactt tgcgcagtgg gtaagcgctg cggacaagaa ggccgagaag 4620
gcgaaggacg agaagaactg gtgggagggg gtgaaataa 4659
<210> 30
<211> 360
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(360)
<223> BLCPAMOF_01513
<400> 30
gtggtggaga agggcctgga cgttggcttt gccttcgatg gtgacgctga ccgctgcctg 60
tgcgtggatg agaagggtaa tgtcatcact ggcgaccata tcctgtatat ctatggctgc 120
tatatgaaag agcatggcaa gctgctgacc aatactgtgg ttacgactgt catgtccaac 180
tttggtctgt acaaagcgtt tgatgagcaa ggtatcggtt acgccaagac tgctgtgggc 240
gacaagtacg tatacgagta catggcgaag aacggctgtc gtatcggtgg tgagcagagt 300
ggtcatatgc ggataatgac agtctgttca gtttcattac agtccaacag caagcgatga 360
<210> 31
<211> 402
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(402)
<223> BLCPAMOF_02753
<400> 31
atgaaaaaaa taaaaatgag cgatattttg ctgacggttt gtgcgatagc tatcgtttgt 60
ggtatcggaa gtttgacact tcgcggaaag aagactacag aaaaactcat aatcggagat 120
tggtatcagc agtggtcgga tagcttgact ttttcaattt atgatgacag aacggttaat 180
gttcctggtt cctatggtct tggaaaatgg tctctagtaa acgataatca gctgatcctt 240
tcggattttt atggagaaac gattatcttg aagattgaga atattgatgc cgacaatatg 300
gaggtccgac aggtaatcga tggaaaagaa agtcaagaat caatcacatt ctggcacacc 360
gcagatggcg cacaaacgat acgagttaag ggctaccatt aa 402
<210> 32
<211> 180
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(180)
<223> BLCPAMOF_00329
<400> 32
atgaccgtaa aacgcgaaaa ggcattccgc aacgccattg catccacacg gatggagggc 60
ctctcttttt ccaaaaaatc ggagcaggac tgtctgcgct atctggacgg tcatcttgac 120
gccgccaccc tcgtccgtga ggttctgcgg cagccacagg acactgcggc ccagaggtaa 180
<210> 33
<211> 1386
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1386)
<223> BLCPAMOF_00265
<400> 33
atggcatata ttacgaaatg cggcagctcc tatggtgtcc gctatactta ccaagatgag 60
cagggtaaaa actgcaacaa atgggaaagt tttcccacga aagaggaggc aacaaatcgc 120
aaaaaacaaa tcgaacatga actggcaaac ggaacgtttt tgattccgtc caccatcacc 180
gtcaaagagt ttttgatgga gtggcttccc aaacagtgca acaagcacaa gtgggcaccg 240
cagacctatc aatccaatct gggaacggtc cagaacctca ttattccgta catcggcgat 300
atgcagatgc aaaagctcaa accctaccat ctggaagatt tgtatgccac tctcggcaaa 360
atgccctgcg gccagtatta tgagggcaaa aagcaggtgc tttcggaaaa acaacagcag 420
cggcttctct ccggcacgac catccacgag gtacaccgcc tgctgcggac agcgtttcag 480
tatgcggtgg agtggggcat cctcatcaaa agccccgttc cggtggacag ccctaaaaag 540
tcaattcaag agcgtgccat ctggaatgca gatgagatgt gggccgcact tgccagcatg 600
gaagacccga tcctgcattt ggctgttcac ctcacactgg taggcgcact gcgcgagggt 660
gaagttgctg gcccgactcc ggaagatctt gattttgagg gagcggacgg cacaggcacg 720
ttccgcatca acaagtgtat gcagcgtgtc caaaaggcat cgctggcaaa aacgggcaag 780
ggctgcatct tgcaggaatt tgaagataag cgtgagggca gcaccacaac gctggtgctc 840
aaaaagacca aaacagcatc ttccaaccga accatcttca tgacagccgt gctgaaagag 900
gaactgaaac actggctaaa gcgtttggaa atggacgaag ccgttgaccc ggaacgctat 960
cgcaacagcg ggatgctcct gcgcttaccc aatggtctgg cggtagagcc gatcctcatc 1020
cgcaaaaagt tcatcaagtg gcaggacgag cacccggagt tcacccgcat tgtgtttcac 1080
ggtctgcggc attccagtgc cacctatcaa ctgatgatct ccggcggtga tgtgaaagcg 1140
gtgcaaggca caacaggcca cgccagtgcc aatctgctgg tcaacaccta tgcacacatc 1200
cagcaggatt cccgtaaaaa gctgggtaaa aagttcgagg aaggcttcta caagccggga 1260
gcaacacttg tgcaggctgc cccggttgaa gcagagccga ccatctccgt gtcggcactg 1320
ttggagcttc tgaaggacgc agacccctct gtaaaagcgc agctccgctt ggctttgctg 1380
acctga 1386
<210> 34
<211> 312
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(312)
<223> BLCPAMOF_00266
<400> 34
atgaacaaat ctcggcctgt tgcgaccaaa actgtgaaat ctttgaatta tacgaaaaat 60
atcttgcaga ccattccgaa taacgataca atggaagtgg tcactcaaac caatgccgtc 120
aagtctccga ctgacagcct gaaagccaca acactggtgt acacggtgga agagattgcg 180
cagatgctgt ccatcagtct gcgctctgcc tacaatctgt gcaacagcac taccgaattt 240
cgtgttcttc gggtcggcgg aagcatccgc gtcccgaaag acagtttcga tgcgtggctc 300
cgggcagctt ga 312
<210> 35
<211> 267
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(267)
<223> BLCPAMOF_00907
<400> 35
atgctttacc catttatgac attgaacgat ggtacggaaa tcgtttattc ctcaccgatt 60
cagaatggaa atcaggaaca ggtaaaggtg cagatcgaga cgcctgtaga aaatggcttc 120
aagtctgcga catgtatcct gccgggctat ctgtggacga acaatggcta ttccgaaatc 180
gagatggcaa gcctgaaaga actgatcaaa tcgacagcac atctgctgat tcgtttctct 240
cgtgaggggg gaatcgagag tgcctag 267
<210> 36
<211> 915
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(915)
<223> BLCPAMOF_02129
<400> 36
atggcaaaaa acattgcagc atcccgtcaa aagaagcccg gcggtctgtc cgataaggtc 60
agcgacatcg ttctggtggt catctgcgcc gccgtcatgc tcatcgtggc ctacccgctg 120
tactacgttc tggtggcatc cttctcagac ccctatgacg tttacgccgg caagaccttc 180
ctgcttccca gccagttcac cttgaaaggc tatcaggctg tgtttgcaga cagcgcgctg 240
ttctccggtt ttatcaacag catcaaatac accgtcatcg gcacgattta ttcggtggtc 300
atgatctatc tggtggctta cccgctgagc gtgaaagacc tgcccggacg caagtacatc 360
agcctgttct tcgtcatcac catgtacttc ggcggcggtc tggtgcctac ttacctcatc 420
gtcaagcaga ccggtctgct gggcagtatg tgggcgctgt tcctgcccgg cgtggtggct 480
gtgggcaacg tgatcatcgt ccgcaacttc ttcgagaaca acattcccag agaactgctg 540
gaagccgccg agatcgacgg tgcctccaag tggaccgtct ttgtaaagat ggtcattccc 600
ctgagccgtt ccatcatggc agttatggtg gtgtacagca tggtggccta ctggaacgac 660
tggttcaccg ctctgatcta cctgagagcc gatcaggctc cgctgccgct ggtgctgcgc 720
aatatcctga tcaagagctc caccagtgcc agccaatcct ccatggtagc gggcggcttt 780
gcagaactga ataagctgac cgaaatgatc aagtttgctt ccatcatcgt ggcagctgcc 840
cccatgctga tcgtttaccc ctttgtacag aagtattttg aaaaaggctt catggcaggt 900
gccgtgaaag gctaa 915
<210> 37
<211> 195
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(195)
<223> BLCPAMOF_00483
<400> 37
gtgaaagaag ttccgatttg gcaaaagagt aatctgacct tggaggaagc ggcggcttac 60
tctgggattg gtatcaataa actgcggtca atgaccgata gcgatgaatg caagttcgtc 120
ctttggaacg gaaccaaacg gctgatcaaa cgccgtaagc tggacgaata tctggacaag 180
gcattctcga tctga 195
<210> 38
<211> 1158
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1158)
<223> BLCPAMOF_00482
<400> 38
atgatgctgt gcgtcatatc ctactgggta ttatctggcg caaaaaggcg gcagatccag 60
cagcttcgct gctgcattct ccccaccaag ctgttgaaac ggagggatgt ctatctgaaa 120
ttaacacgac acaacggacg agccgggacc cacggcacct ataaccccaa gcacaatgac 180
cggagtttca accttgccaa cagtgagcac atcgacccgg aacgagccaa gggcaacatc 240
tacggggact gcttccacgg cttccgttcg gctctcaatc cgcaagaccc ggacgatctg 300
gcagcgacct tctcggaggt agaacgacaa ttttacgaga gccgctattc caattttgtg 360
gaaagtcaga acgagcgcaa tgccaagatt cggcacacgg agcgtaaccg aaccatagag 420
gacttgcttg aaggtaagaa aacctgcccg gaagaaacca tctatcagct gggaacaaag 480
gacgaccatg cttcgggcga agttctgctg gcggtcgtga cggagtttat tgaggagttc 540
aaggcgaggt tcggagacca tgttcatgta ctggactggg cgttgcatct ggatgaaagt 600
acaccgcata tccacgaacg tcatgtgttc gactgcgaga acaagtatgg tgaggtggca 660
ccccagcagg aaaaggcact ggaagcgttg ggttttgagc tgcctgaccc gggcaagccc 720
ctcagccgcc gcaacaaccg caagattact ttcgatgccg cctaccggaa gatgctgttt 780
gacattgcca aacggcatgg gctggaattg gaggaagaag cggagtacgg cagccgcaag 840
tatctggaaa agcaggattt cattcttgcc aagcagaagg cgcagcttgc tgcccagcag 900
agcaagctgg acgaactgac cctcagggtc agcgacatgg aaacgctgat cgacgaagtt 960
tcggctgcgg cctacgacaa ggcggtggag gtagtggcgg acgtggtacg caccgagacc 1020
cgaaaggaag atatgcggat gatcgaggat acgaaaaagt gggtgttgtc cccggaacgc 1080
aaggctccgc agtccacacg ggagtacacc gcaaaacatc tggatagcgt gctggacaag 1140
ttcctcaaga ccatgtag 1158
<210> 39
<211> 279
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(279)
<223> BLCPAMOF_00908
<400> 39
gtgcctagtt tgttccggtt gttcggttat gtgattttct tttggagcaa cgagggggca 60
ccgctggaac ctgtccatgt tcatgttgcg aagggtgtgc cgaatgccaa tgcgacaaaa 120
atctggatga cagaagcggg tggctgtatc atcgccaata ataattcgaa gataccgact 180
cgaacgttga acgctattgt ggatgttctg gaaagccgtt ccagttacat cattgcacag 240
tggaatgacg tgttcggaga gtcgaaattc tattgctaa 279
<210> 40
<211> 1233
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1233)
<223> BLCPAMOF_00484
<400> 40
atgcaaagac gtaaagataa taaaggccgt gttttgaagg atggcgaggt ttaccgcaag 60
agcgacgggc tatatatgta ccgttggact gctaaaaacg gaaaacgcca taccatctat 120
gatgcaacct tggaggggct gcgggaaaag gaagaaaaaa tccagcatga cttggcagag 180
ggcatccgta tgccggagtg caatttgacc ctgaacgatc tgtttgaact gtggcgtaaa 240
aacaaggtgg gcttgaaaga gcacaccttc gccaattacg tttatatgta caatcggttt 300
gttcgggatg aaatcggcat gatgaagctc aaggacattc gcaagtcgga tatccgcagc 360
tactacaatg gcatcgtccg caacggcaag atggcgttga acacgctgga aaccgtccag 420
aatgttcttc atcaggtctt tgcggtggcg gtggacgatg agtacatccg tgtgaatccc 480
acggatggtg tcctgacggc tataaaagcc gcccaccagt acgaaacgcc caaacgccac 540
gctctgaccc tgccccagca gcaggcgttt ctgaatttca tcaagaaaac gccgaagttc 600
cagcattggc tcccgatgtt caccttcatg ctgggtaccg gatgccgcat ctcggaaacg 660
gttggcctgt gctggggtga catcgacttc gagagtgggt ttatcaccat ccagcacaat 720
ctggtgtacc atgaccacga ggtcggtggc tgctatttca ccatgtctac ccccaagact 780
gccgccggta agcgggcaat tcccatattg cctgaagttc gaaaagcgtt ggagcaggaa 840
cgaaccaatc agcaggaact ggaactggtg tgtgagtacg aaatcgatgg tatctcggac 900
tttgtgttcc tgaaccgctt cggtcagccg cagaacccgc agacggtcaa ccgcgccatc 960
aagcgcatca gcgtggcata caacgaagcc gaactggaaa aggccgaaaa ggaaaagcgg 1020
gagccgcagc tgttgccgcc tttctcctgc cataatctcc ggcacacatt ctgcacccgg 1080
ctgtgtgaaa atgaaaccaa cctgaagatc attcaggaca tcatgggaca caaggacatc 1140
agcaccacga tggagattta cgcggaagcc accaaggaag ccaaagccca ttcctttgca 1200
aatctgaacg gtaaactggg catttcggtc tga 1233
<210> 41
<211> 432
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(432)
<223> BLCPAMOF_01424
<400> 41
atgaaggata gcatttgcac cgtcatcggc ctcatcggcg ggaccattgc cgccttattc 60
ggcggctggg acactgccct gcagacgctg gtcatcttta tggccatcga ctacatcacc 120
ggtctggtgg tggcaggcgt gttccacgcc agccccaaga ccaagaccgg cgcgctggaa 180
agcaaggctg gctggaaggg cctcatccgc aagggcgaga cgctgctcat cgtgctggtg 240
gcctgccagc ttgatgctgt catcggcggc agcttcgtcc gcgacgcggc gatcatcggc 300
ttttcggcca acgaggccat ctccatcgtc gaaaatgccg gcctgatggg tctgcctatc 360
cccgcagcca tcaccaaggc catcgacatc ctcaaacagc gggccgagac gcccgagaaa 420
ggcaagaact ga 432
<210> 42
<211> 1659
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1659)
<223> BLCPAMOF_02128
<400> 42
atgaaaaaga tgatctctcg ccgcaatttc ctgaaggttt gtgccgttgc cggttctgcc 60
gtggcactgt ctgcctgcgg cggcagcaaa aaggccgctg cacccgatcc ttccaacacc 120
gaccagacca gctttgacat cgtgggcggt cagtccgccc tgagccccgg ctacaacgac 180
aacgaggtgc tgaagaagct ggcagataac gtgggcgtta aactcaacta cgagaccatg 240
agcgactccc tcagcgagca ggtgaacatc cgcattgcag gcgaccagct gccggacgcc 300
tttatgggtg tgggcttctc caactacgat atcgccaact atggtgcaga cggcaccttc 360
ctggacctga ccccctatat caacgccgag atcatgccca acctgaccaa gatcctggac 420
gagcacccca acatccgtgc agctatcacc atgagcgacg gctgcatcta cggtctgccc 480
gctgccgagc agatgggcac tgccggcatc ggtgacgacg aagattacag catcttcacc 540
attccgcagt tctccatgat caacaagcgc tggctggacg agctggggct ggaagtgccc 600
accacgctgg acgagctgca caccgccctg aaggccttca aagacaacga tatgtccgcc 660
aaggtctacg gcaatgcacc cggcagcacc atccccatgt ccaccggctt tgacgagtgg 720
tgctggggtc agaacatctt ctacgcaggc ttcggattca ccaactggcc caacgatgtg 780
tgcaacgatc tggtgctgca gaaggacggc aagtgccgct ttgtctgcgc cgaggacaac 840
taccgcaagg cggtcaccta cttccacgac tggtacgccg agggtctgat ggacgtggag 900
atgttcagtc aggataccaa ccagctgctg gctaagggcg cacagggcta tctgggcgtt 960
tccacctggt ggtacatcga ggaactgatg ggcgattacg ccaaggacta tgtgttcctg 1020
cccgtgctgg acggcccgga cggcactcac aacgtcaccg tgcgtaccgg cggcggtacc 1080
aacagcggca acctgaacgt gaccaacaag tgccagagcc ccgccaacct gctgaagttc 1140
tttgaccagt ggtatgacgg cgagaccgtg atgcagctgc agtacggccc catcggcgtg 1200
ttcttcaccg agcaggacgc caacggcaag tggaagtcta tcaccgagga agaagccaag 1260
gcaaagtaca acaagggtgc cggtgagctg aaatccacct acgaggtctg gggtcccaag 1320
ctgatcctca gcgagtacta cgacaagtac ttctacatgg aggaccgcgc catcgagcgt 1380
ctgaccgacc tgaaggactt ctggatgccc tttgtggacg acaccaccac ctaccccatc 1440
gactgcgtgt tcaccagcga ggaactggac accatcgacc gctaccgtgc ggattttgag 1500
aacgcagtct ctgagcagga aggtctgtgg ctgaaggacg gcggtccctc cgacagcgag 1560
tgggcagcct atctggacac cctgaccaat agctgcggca tggataagct gctggcagct 1620
taccagggcg catacgaccg ctacaaggcc aacgtctga 1659
<210> 43
<211> 399
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(399)
<223> BLCPAMOF_00817
<400> 43
ttgaagaaaa aatacaacac accccaccgc tgccatgtgg tcaaaacccg catgaccgag 60
gaagaatacg ccgactttac cgagcggctg aaacactatg acatgagcca agccgaattt 120
atccggcaag ccattacacg ggcgaccatt cgccccatcg ttaccgtttc cccggtcaat 180
gatgaactgt tgtccgccgt tggcaggctg accgccgaat acggaaaaat cggtggcaac 240
ctcaatcaga ttgcccgcgc cctcaacgag tacggcacac catacaacgc cctgtccgtt 300
gaagtccgcg ccgccatttc tgaccttgct gccttgaagt ttgaagtcct gcgaaaggta 360
ggtgacgctg ttggcaacat tcaaacatat cagctctaa 399
<210> 44
<211> 207
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(207)
<223> BLCPAMOF_00378
<400> 44
atgaaccgtg ttgacgtgga aagtgctgtg atcgctatgg gggatgtggc tgtgtgtatc 60
aagatggtgg acgacgcgac cgaggagggg aacgcggtgc agcagggccg agcggtgcaa 120
gtccttatgg acatcttcaa ggccagatat gccgctcttg tgtcctgtgt tcagggcgac 180
cagagcgccg cgcagggcag tttttga 207
<210> 45
<211> 396
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(396)
<223> BLCPAMOF_01019
<400> 45
atgccacgga cgaagaaaaa agtgaaatct atcgtaaaga caaaagtaat ctccgcacga 60
gttacagaag tagtacatga acttttacac cagcaggccg aagatgcagg aatgaccctc 120
tctgaatttg cagcgcagat gctgatgaaa ggtcgcgtga atacctcgta tgtgttctat 180
gtccacccgg acgagatcga agccatcaca cgggagtttg ctgccatcgg gaataatctg 240
aaccagatcg cgatgttttt caacagcggc ggtatccagt cgcgcgctat gctcgaaacc 300
attaaccatg caattgcctg catttttgaa atgcgggagc aggtcgcaga aatggcagga 360
aagaattatg gcaatcttaa agcatatcgc aagtaa 396
<210> 46
<211> 777
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(777)
<223> BLCPAMOF_02134
<400> 46
atgggactgt tttttccgag tgaccccatc gtccacggcc agcgcgccaa ggggctgccc 60
cgttatcagg aacttctgga acgcgactgg aaaagtttcc tctttgccga cttcgtgacg 120
ctgggcctgt gcatcccgta tggtctgggc gtgggctacg cgctgctttc ttccagccta 180
ctggtgctgc tcccggtctg cattctgggc gggcttctgg tcggcccggc gatctccggc 240
atgatggatg cgttgttccg cagctaccgg gatgcgcccc gcggctggtg ggagaattac 300
tgcaagggca tgaaacagaa ctggaaatcc tccctcctgc ccggcatcgt attctgcctt 360
gcgctgggca tcgagctgtt cttcggcatg gtgctgttct ctgcggaaca gctgccaggc 420
atcgggacac tggccgtttt ctttgtcgga ctgctgttgc tgctgatgct gttcaccgcc 480
ttttggccgc aagtcgtcct gtttgaggaa agcaacctgc accgactgca aaacgccatc 540
ctgttctgcc tgaaatatgg caagcatgtg atcggcacgg cgatcctgca actgggctgg 600
tggcttctgt tcgtgttgtt tttgccgtgg acgggctttc tggtgccgtt cctcggtgtg 660
tggtttatct ggttcgtctg cttcttcctg ctgtattccg attttgatgc cgcgtatggc 720
attgaggaaa agatccggca gcagttcccg gagcagacac cccgctacga tgaatga 777
<210> 47
<211> 1149
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1149)
<223> BLCPAMOF_01009
<400> 47
atgataaaga atgttgtgtt aaaaaagtcg ttaaaaaata gtgttttcaa agtcgttagt 60
ttgctgaata atgtagtgcc aaaacataac aattatattt tgttatattc aggcaataag 120
ggaattagtt tcaatttgat tccgctccga gattatctgc ttttaaacgg atatgatacg 180
aataatagaa tcatttgtgg aattgaagat atgaaatatg cggaaactga taactgcaca 240
tatgttacac atgttaaagc tatattttat tatctaaaat ctaaatatgt tttctataca 300
gctgggcagc tgcctattaa accgtcaaaa agtcaaaaag tcattcattt acagcatgga 360
atcacgttta aaacttgtgg aaagcttact cacattaata acggaaatga atttttcttt 420
acggattgtt tggctacatc gaatatatac aagcctattt atagtaaagc ttttggttgc 480
tcggaagaaa atatatatat aaacagtgaa cctgtgacgg atgtattttt taatgggtat 540
aaaaaatatg atttaggtaa ttacaacaag ataatattgt ggacaccaac gtttcggcaa 600
tctgattatt tgggatatga tgattcagaa acagaagaat tattaccact gtttgaagaa 660
aaagattata gtaggcttaa tgaaatactc aaagaatata attttcttct tatggtaaaa 720
atacatccgt ctcaagactt gagtagatat agtaaattga aatactctaa tttgcaaata 780
ctatcaaatg atgattttaa tcagatggga atggagatat ataatctatt gccccaggta 840
gatgctatta ttggagacta ttcatctctt tgtatgcagt ctttgttgtt ggataaacca 900
atggcatatg tagtacctga tatggaagaa tattctaaac gaagaggatt tgcatttgat 960
ccaccgacag actatatgcc tggagatttg ataaaagata aagatcagtt ttatcagtgg 1020
ttggatgatt ttaataaagg aatcgataaa tatgaaagta tcagaaataa agtaaaaaat 1080
aaagttcatc tttattcaga tggtaaatcg tgtgagcggc ttgtggaata ttgtggaata 1140
aataagtga 1149
<210> 48
<211> 1662
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1662)
<223> BLCPAMOF_01020
<400> 48
atggcaatct taaagcatat cgcaagtaag agttccaact atggtgctgc actggagtat 60
ctgattttca agcatgatga gcttcggaaa actccgatcc ttgaccagaa cggaaatcgt 120
atcatgcgag atgagtttta tctggacggt ctgaactgtg aaccctattc ctttgatgcg 180
gcctgccagc agttgaaccg cgagtaccag aaaaacaaaa acaagaatga aatcaaaagc 240
caccattaca tcatcagctt tgatccacgg gacagcacag aaaattgttt gacggggaaa 300
cgggcacagg agcttgggct ggaatacgca aaagcaaatt ttccggggca tcaggcattg 360
gtctgtacgc acatggacgg tcacaatggc agcggcaaca ttcatgtaca tatcgtaatc 420
aacagcttgc gaaaattgga tgtgccccag cagcccttta tggagcgatc cattgactgc 480
aaggcagggt acaagcacca cgtgacgaac gagtatctaa agcacttgca gaaatccctc 540
atggatttgt gcaaccgtga atttctgcat caggtcgatt tgctgtcacc atccagaacg 600
ggtgtgaccg aagcggagta ttgggcacag cggcggctga atgagaaaaa acaggaagtc 660
gaaaaggatg gatttacgcc aaatccgaca aagtttcaaa cacagaaaca gcttatccgg 720
gatgccgttg ccgtcgcccg tgagaaagca atctcgtatg aagattttca aaacatcctg 780
caggatgaat ataatatttt tgtcaaaaca caacgtggtc gttatagcta tctgccgccg 840
gaacggaaca agttcatatc ggagcgttct ctgggagaaa gcagcaaaag agaatgtctg 900
gaaggattct ttgttcagaa cgccgagaag aatctgcggt acaaggaaga tcccatactg 960
atctttacga ccagaactag gctgcggctt gttgtggacc tgcaggagaa tgttagggca 1020
caggaaaatc tggcctatgc actaaaggtc aaaatcagca atttgcagaa aatggccgaa 1080
acgctggtat gggtacagga gaacaacatc aacgacctga cggaactaaa cgatctgtgt 1140
aagacagcac aggccaatgc gcaggctgcg tatgaacgac tgtcacaggc agaagatgaa 1200
ctgtacaaaa tcaatgaaca gattcattat gcggggcagt acctttctac aaaagaggtt 1260
cagcagcaat ttgcgaaagc aattttcaag aagaaattcc gtgcagagca ttccaagaaa 1320
ttggatgcct atgcagaatc cgtgaaatac ttccgggaag aaaacgatgg aaagctgcca 1380
tcgctgaaat ctttgaaaaa gcggaaagaa gaactgacca aagaaatcgc ggagaggaaa 1440
aaggcatatg ctcccctgag ggaagaatcc aggcgtttgg aaattgcatc ggataatgtg 1500
tacagcatct tccaaaaaac aaatgagatg aaatccgacc ttgcatggaa acgcgagtgg 1560
gaggccaatg tccgcgaaaa ggcaaggcag gagcaggttc gacaggaaca gcgcgtacgt 1620
caaccgaaac gtaagaagcg cagctatgat atgagcctgt aa 1662
<210> 49
<211> 384
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(384)
<223> BLCPAMOF_02754
<400> 49
atgaaaaata tcacgcgacg tggattccta cagcttacgg cggcgacggc tctggtgtgt 60
gcaacagctc cgctgacggg atgcgggaag aaaaatatta aaaaacttgt actgggtgac 120
tggtacatgg aaggctatag ccgactggag tacgcaatat atgatgatgg aagctgtcag 180
gttcggagtg ggtatggcct tggaaaatgg tcggtcgtag atgacgacaa acttagaatt 240
tcagattttt atgggcagac actgatttac aaaattgaaa aaatcagtaa aaagtcaatg 300
acgcttagac tgatttggga tggaaaggaa agcgaaacaa cagatacatt ctaccacacg 360
gcagaagagg cagaaaaaca ttga 384
<210> 50
<211> 579
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(579)
<223> BLCPAMOF_00910
<400> 50
atgaaggtcg catatgtccg cgtcagcacc gaagaacaga acgaagcgcg tcaaatcgaa 60
gcactcaaga aacacagcat cgagaagtgg ttcaccgaaa aagtcagcgg caagagcatg 120
gacaggcccc aactccaagc aatgctcgac tatgtacggg agggcgatac cgtctacatc 180
cacgacttta gccgcctcgc acgcagcacc aaagacctgc tcgaaatcgt ggagcggttg 240
caggccaagg aagtgcatct cgtcagcaac aaagagaatc tggacaccgg cacacccacc 300
ggcaagctga tgctgacgat gattgcggcc atcaacgagt ttgaacggca gaacctgctg 360
gacagacaac gggaaggaat cgccatcgcc aagcggaatg gagtctacaa gggacgcaag 420
aaggtcacca tacccgataa cttttctgcc ctatatgacc ggtacacccg ccgggagatg 480
aacaaaggcc aacttgcaga agctcttcat gtcactcgtc cgacgctgaa acggatgata 540
cgggagcatt tatcagcaaa aaatccccaa aattcttaa 579
<210> 51
<211> 543
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(543)
<223> BLCPAMOF_00917
<400> 51
atgaagagaa gagtatgctt cctactgcta ttgtccgtat tcatgtgcag tatcctaaca 60
gcttgcagcg gttctggtgg tgctgtctca ggacccaata attcttattc atcgggtact 120
tcccaaaaag accaaatcac cacaagcctc ggctggttgc atacacaatc ccatagcaca 180
cctgcttccg gcagtggcgg atatggcagt aatggttggg gatacggtga aagcacatac 240
tacacacttg aaaccgatat aaccatagaa aatacgggtg atgtcaccgc caatattgac 300
aattctctct ttagtgccta ttgggataac gataagcttt ccccttatag ctccggcatt 360
agccctgttc aattaacccc tggcaagaaa atcaccgtgg aacttgcata tgaaattact 420
gcaaatcaat ataacagctg gtactctagg ggtcataata ttacaatact tattcaatat 480
ggcggagact ccttagctta tgtttattct acaactacag atgaaattac tgtagtccaa 540
taa 543
<210> 52
<211> 528
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(528)
<223> BLCPAMOF_00916
<400> 52
atgaaaagaa aagtttgttc actgcttctt atggcagtat tggtatgtag tctcctgact 60
gcttgcggcg gctccggagg ttctgtttcg ggtccgaatg gttcttatcc taccggaaat 120
aacgaaatct ccactagatt tgaccaaatg tataccgatt attacagaac aggttcaggt 180
gaccgtgtat ttaccagcag cggttggcat tgggattata cttattacta taagcttcat 240
atcaatatca ctattaagaa tactggtaac actgtggcct atattgatga ttctaatttc 300
atggcatatt gggataaaga cgagctgtca cgctacagca gcatcggcag catcaaactt 360
tctcccggtg agcaaacatc cgttgacctc gtatacaaca tgagtgaatc tcagtataac 420
agttggaata tttccggcca taacgctatt ttaatcatcc aatacggaga tagcgcatta 480
gcttacgttt attctactga aagcagagaa gttacagttg ttcgataa 528
<210> 53
<211> 288
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(288)
<223> BLCPAMOF_00918
<400> 53
atgaagatga cctcagaacg aatcaaggca ctgcgagagg cacgcggctg gacacaggca 60
gagcttgctc ggcggctgag tatcacgcgc aatggtgtca actcgtggga acaagggctt 120
tctatgccgt cgcctgcttg tctggttgac ttggcgaagc tgttttctgt ctcaaccgac 180
tatctgttgg gtgtggagcg gttggagacg gtcaatgtca cgggcttgaa tgaggaagat 240
attgcattgt tggcgcagtt ggccgaccgt ctaaggggca atcattga 288
<210> 54
<211> 621
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(621)
<223> BLCPAMOF_02133
<400> 54
atggaagatt ctgacgaaag gagcaaaccc atgaaacgga atggactgtt tgtgctcgtc 60
cttgcactgg cggcggtgct gtgtaccggc tgtggcgtaa aggacgagga tttgaaaagc 120
gacccgctgg tcaatgcaga tggcacagca ccggtgggca gtacactggt cgctcctgcg 180
ccgcaggatg atttcgttct gctggacaac aaggatatcc tctctgcaaa cggtctgtat 240
tacgcttcgt gggtcaacgg cgatgcccag ccctacgaaa acagtgaggg caagaccgtg 300
gacctctacg atgcgcagct cacgcttgtc gtgcaggaaa acaaaacgga ggacaaagcc 360
gcctctgcgg tagagggctg gcagacgctg gcacagcaga actacgatat ttccgacaca 420
cagaccctga ctgccgccgg gcaggaatat acggtcattc agttcaccta tcaggatgaa 480
agcaatccgt atgcgaccgg cgttgcggcc ttcgcccagc gcggcaccag tgccatcgag 540
tgggagcttt cctgtcagga cagttattcc ggcgatgcgc tgaaagtcct gaccgatttt 600
ctgaacagct gtacttatta a 621
<210> 55
<211> 699
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(699)
<223> BLCPAMOF_02132
<400> 55
atgaccgccc cggaaaaagg ccggtggtac tgggcaaaaa actggctaca ttaccactgg 60
gtctatcttg tcatcgcagc cgtggtgctc tgggttggca tcagctggct ggccaacgcc 120
ctgcattggg gcgagaccct gccggattac cagatcgcct atgtgggcaa aagttctctg 180
ccggaggaca ccgcccacgc cattgaagca gcctttgcgc agtacggcga agatctgaac 240
ggcgacggaa tcgtttcggt caagctcaac cagtatgtca gcgacactga ggacatggaa 300
aacgcttcta cttacgcgct tgcggcgcag atgcagtttc tttccgatat gaacgccgag 360
gaaagctatt ttctgctgct ggatgacccg gcgcattttc aactggacta tcaggcactg 420
gcaaactggg acggcacccc gccgggcgac aacgactata ccgccaccgg aaagaccgtg 480
ccttgggcag actgcccggt gctggccgga tacgaccttg gaacgtatca gaccaccgtg 540
ttgggaacca ccgttactgg cagcagcgca gaactggtaa acggattatt tttaggccgc 600
agggcctttt atgaagagcc cacgaacgaa aaagccgctc atgcccggga aggagcacag 660
cggctatgga agattctgac gaaaggagca aacccatga 699
<210> 56
<211> 1008
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1008)
<223> BLCPAMOF_02131
<400> 56
atggcaaaac agaacaccgc ccctactatg aaggatgtgg ccaaggaggc aggcgtgtcc 60
ctcggcaccg tgtccaaggt catcaacggc atcccggtgg gcgaggaata ccgcaaaaag 120
gtggagcagg ccatcaagga actggactac cacctgaacg cctatgcgcg cggcctgaaa 180
agcaaccgca ccaataccat cgccgtcatc ctgcccacca tcgcacatcc ctatttcggc 240
ctgatcgctc attgcatcaa cagctcgctg caaaagcgcg gctaccggat gctgctctgc 300
gataccgact atgacaatga aaaagagcag gaaatgatcc gcatggccga gcagaacaag 360
gtggacggca tcattgccct gacctatgac ccgaagctgg aagtaccctc ggagatcaac 420
tccgtctcca tcgaccggta tctcggcgcc aacatcccct gcgtggcatc cgataactac 480
gcaggcgggc ggctggccgc cgaaaagctg atggaaaacg gctgcaggaa gctcgccttc 540
ctgcgcgtcg gttccagcat cgtgggcgag accaacaaac gcaaggacgg ctttgtggcc 600
gcctgtgaag ccgcaggcgt tccttatgaa ataaagaatc tggaagatgc gcgggacggc 660
atcgtctttg accccatggc cgagttcgcg gtgttcctgg acgatcatct gcaggacggc 720
gtgttggagt ttgacggcat cttctgcgtg accgaccgtc tggcctacca gattgttcag 780
ctgctgcgtc ttatggggct tcgggtgccc gaggacgtgc aggtcatcgg ctttgacggg 840
ctgcgcacct tcggcgacat ggattattac tgttccacca tcgttcaacc cgtggacgcc 900
atcgcagaga cctgcgtgga agtcgtgctg aacgagaacc gcgccaatac cccttccctg 960
ctgtgcctgc cggtcagcta cgcttacggc ggcaccacca aggcatga 1008
<210> 57
<211> 948
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(948)
<223> BLCPAMOF_02130
<400> 57
atgacgcaga cctcgccagc tgctgcacgt cagctggacg ctatcccggt ccaccgcaaa 60
agcctcagcc aacggctgcg ggaaaactgg cagctctatg tgatgctgct gatcccggtg 120
gtgctgacca tcgtttataa gtactggccc atgtacggca tccagatcgc cttccgcgat 180
ttcaaggcaa gccgcggcat caccggcagc gagtgggttg gcctgtactg gtttgaacgg 240
ttcttcaccg cacccaactg tgtgcgcatg atcaagaaca ccgtgctgct gagcctgtac 300
agcctgctgt ggagtttccc catccccatc atcctgtccc tgtgcatcaa ccagctgcgc 360
tttgcaaagt tcaagcgggt ggtgcagacg gtgctgtacg caccccactt catttctacc 420
atggtcatct gtggtatgat caagatcttc ctcagtccgt ccggcggtct gctgaacctg 480
atcctgggca ccagcgtgga cttcctctcg gagagcgccg cattccgtac catttatgtg 540
gcctccggca tctggcagga agccggctgg ggcaccatca tttatatggc gtgtctggct 600
gctgtggata ccagcctgta cgaagccgcc aagatcgacg gcgcgtccat gttccagcgc 660
atcctgcaca ttgatattcc ggagctggta cccatgatcg ttttgcagct cattatgagt 720
gtaggcaacc tgatgaacgt gggctttgaa aaggtgctgc tgctgcagac cgagctgaac 780
aaggccacca gcgatatcat tgccgtgtac gtctacgaac agggcatcat caacgccaag 840
tacagctatt ccaccgctgt gggcctgttc aacacggtgg tcaacatcat cctgctcatc 900
atcgtcaacc gcatcgccaa gaaggcggca gacgtcagct ttgtgtaa 948
<210> 58
<211> 435
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(435)
<223> ICBIDGAJ_00089
<400> 58
gtgaatcaga actttatgtc cgtggctttc cagaaagtaa atgtccgatg tttccaagga 60
catggtaaca ccatcgtatt cgatcgtgaa atgtttggag ttcagttcct gaaggacggc 120
atccattgcc gcagcgaaca gcgtctgatc caaaggtttg acaaggtagc ggaatgcaat 180
gccatatccc tgcacagcgt actcatgccg cttcgtgaca aataccacca aaggatgctt 240
ctccatctga atcaaagact gcgccagctg aaaaccgttg gatggcatct cgatatcgag 300
aagaagcaga tcaaaggatt tcttctgcat ttgcaattcg ctcagaagtt cgtttccatc 360
catgtaagtt tcaatgtcaa agcagccttg cacatcgtac tgctggacgc tttgaacaat 420
gccatcaagg tctga 435
<210> 59
<211> 888
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(888)
<223> ICBIDGAJ_00769
<400> 59
atgaaaaagg aaaagaacgc ggcaaagccg aagacaaagc ggcccgcaaa acctaaaaag 60
gaaccggtct cccagtggat gaccaatccc ctgaacgaac aagttctgga ttaccataac 120
tatgagatga cacagggcga gcaggtattg tattttattc tggcattttt gatcggtggt 180
gtggtgagcc agttcttcta cggcggcctg ttccaggagg acggcgcgcc caccctgctg 240
acctatatca gcaatgcagc ggcatttgtg gtagtcggcc tgattgcagg cagggtattt 300
ctgccggtgc gcagccgcaa gctggcggaa aagcgccgcg atgtgctgcg caaacagttc 360
cgcgatatgc tggagtcgct tacagcttcg ctggcagcta acagcacggt gcgggatgca 420
tttaatactg catacaccga tatgtgtatg cagtattcgg acgatgcact gattgcaaag 480
gaactggatc agttccgccg tgcagagcag atcaatgtga cactggacgt tatgatggac 540
gattttgcca agcgcagcgg catggaagag atcgaagact ttaataatgt attccaggtg 600
tgctacggcc ccggcggcaa catgagccgc gtgatcaacc agacccacga tatcatctgc 660
gagcggatgg aagtggagga cgagatccag gccaagatcc acgcaaatga gaccgaactg 720
aacgtgatca tggtggcgcc tgtgctgatg attgcactga tgcgcagcac gaatgcaaca 780
tttgcacaga atctggcttc accgacgggt gttgcggtcg ttacggtcgg ccttgcaatg 840
tttgtgggcg cgtatatctg gggccagaaa attattgcgg tggggtga 888
<210> 60
<211> 1275
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1275)
<223> ICBIDGAJ_00768
<400> 60
atgacgacag aggaattaaa ggcactccga agcagagttc tggacgccat caaccgggag 60
ctgcagccta cccggatgaa cgacgaggaa ctgctgaagg caatcacagc tttggtggaa 120
cgggaaggaa ggggtggata cctgctccca atccagaaga tggataccgt caacggcatt 180
tataaaatgt accgtggtct gggcggcctg ctggattcca ttcttgcaga tgaaaatgtg 240
acagaagtga tgatcaatgg tcccgacaac atctttgtgg agcgcagcgg ccgtctgaca 300
cgggtggaca agcacttcaa ggatgagcag gagctgcgca gggtcatcga cttgatcgtg 360
ggcaaggcgc accgtgaagt gtcggaagca aatcccattg tggatactcg tctggaagac 420
ggcagccgtg tgaatgtggt gctttcaccc attgcattga gcggctctac tattaccatc 480
cgtaaatttt ccaagcagcc tatgactatg agcaagctgc tggaatacgg ttccattacg 540
ccggaagtgg ccaatttctt aaaaaagctt gtggcggcac ggtacaacat tttcattgcg 600
ggaggtaccg gcagcggtaa gactaccttt ttaaatgcgc tttccaatta tatcccgcat 660
gatgagcgta tcatcaccat cgaggattct gctgagctgc agatcactca gattccgaac 720
atcgtgcggc tggagacccg caatgcaacg gcgtcttcgg gcgagagtaa aaaaattgac 780
atccagagtc tgatccgctc cagcctgcgt atgcgtccag accgcatcat cgttggcgag 840
gtacgcggcg cggaagcatt ggatatgctg caggccatga acactggtca cgacggaagc 900
ctttctaccg gacatgccaa ctcggcagag gatatgctca gccgtctaga aaccatggtt 960
ttgcagggcg aggcggcact gccgctgaaa gctatccgtc agcaaatctc cagtgcagtg 1020
gacatcatga tccatctgtc ccgtctgcgc gaccacagcc gtaagacaat gatggtcagc 1080
gagatcttac cgcatctgga cgaaaacggt gacatccgtc tgaatccact gtttgagttc 1140
cgggaggatg aacattctac attgcagcat gtttcgggtg cgttggtgcg tacagaaaac 1200
cccatgatcc agaccgataa atggactcgt gcggggtttt tactggaaga tatccccgct 1260
ccggtgcgga aataa 1275
<210> 61
<211> 1083
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1083)
<223> ICBIDGAJ_00767
<400> 61
atgattgttc gagtcggtct gcttgacaaa agtgataatt atatttcaag acttgccaat 60
tatcaaaatg tacattccaa tgaagcggta cagtttgaaa tttatctttt tacggaagaa 120
cagatgctgc gccgacagat gggacgcggc gggcgaatag acgtgttgat tgcggaagaa 180
gaactgctac agtcgccaga agagtacgca cgcagtatgg agcttgcgtt ctggagcgag 240
gataagcacg agcagatgcg cgatggctgt cctgtgatat gccgttacca gaaggccggc 300
gacatctttc ttactattca aggacttgcc tccaaacgcg gcaaaggttc ctcaagctat 360
gcgctgcagg aaaatggaaa aatctgcctg ttccttggcg gtgcgggtgg tgcgggctgt 420
agcacagtag caatgggctg cgctgctgca ctggctgcac aggggcagaa cactatttat 480
ttcagcctga aacagaaaga agaaaacgga caattccggg taagcggcag ttcgctgacc 540
gatgtaatgt atgaaatcgg tatgtggcaa cagctgggcg gcaccgatca ggggcagttg 600
cagatgaagc tgcaaagcat gctccgcaag gacgatgaaa ccggtgtata ttcttttgca 660
ccctttgacc tgccggtgag cgcaatgaac tttggccctg atgatatgca ggcattgctg 720
catgcggtcg gaggtctgtg cgagaggtgt gtggtgtgtg cagatagcta cctttcctca 780
acgttgctgc ggggcatccg ccttgcggac tgggtgatag tagtaagcga cagcaccacg 840
gcaggtaatg aaaaaacaaa gaagttgttg aactcgttgg aagcaatcga cagcatggat 900
gaaaaactga ttgaaggtag cgtggaagtc gtctacaaca agttcggctc ggctggccag 960
aagatggaac tgcccaagta tgcctgtgaa cttggtacga tcccgcgcta tcagaatgcg 1020
gagaaaaaac gcattgttca ggagttacgg gtcagcagtg tctattcaca gctgaacaac 1080
tga 1083
<210> 62
<211> 318
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(318)
<223> ICBIDGAJ_01574
<400> 62
atgaagttga aatatgcatt ccaacgtggt gttgcatcag cactgatcgc aggggttgtc 60
cttacggcgg gtctgcccgc actggctgcc agcggcgcag aggctgcgga aaccgaaagt 120
gtggcagtgg ttcaggtggc ttcctcttcg gatgaggggg ctgctcagga cgaatatggt 180
gtggctgcgg cgctcatctc ggaggatgat acgccgctga gcattccgga tgaggagacc 240
ccgccttcgg gcaatgccgg aacgggtttc tggagcgttt tgttccagct gctgaagcat 300
ctggctggga agcactga 318
<210> 63
<211> 546
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(546)
<223> ICBIDGAJ_01364
<400> 63
atgggacgtg gcaatgtttg tgtgaccggc tcgtatgagg gcttgttcta catcgacaac 60
gatgatctgc gggtctaccg caggaatgac ccctacgcca aagaggagga aaccagctta 120
cagcgcgacc tcagctgtga agacttttcg agcggtgaat ggcttcttga tgaggtcggg 180
agcagttacg aggaagaaga cgctctcgaa tgcttttgtg ccgaactgcg gaagctctgt 240
cccagcttcc agcctgcggc caactcaaac gtctggctcg gcaatgagcg ccgggtcatc 300
ctcgaaaacg agctgtttta catctgcgtg gaggataacg agtggtcact ggccgtcgag 360
cttgtccaga aagacggcta ttccgactgt gagagcgcat ggatggccgg ccttcagaag 420
cggcgctacc ggggatacct tgatagcatg aaaaaggccc tgctggcccg cctgcccagc 480
attggcgttc gcaccgggcc gtggactcac ggaactatca ccagagagga ggctggcgta 540
tgctga 546
<210> 64
<211> 147
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(147)
<223> ICBIDGAJ_01365
<400> 64
atgctgagtg acatgattga tgatctcgtc cgggccgact gcccgcagga aaaggaagca 60
gcttaccggc agctcgaaaa gctcggcgtt gaccgcatta ccgctgatgt catcgccgat 120
gagcgccgaa atgaggcgca cctgtga 147
<210> 65
<211> 351
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(351)
<223> ICBIDGAJ_01366
<400> 65
gtgagccgct atattccccc tgaggagatg aatgaagctc agatcaggga gcagttggac 60
gctgagtata agcactggga tgacctgaag aagaacggct gttctgaccc tgcatggccg 120
gatggtgtga atctgaacct tgttcggaac cacatcatct actggtatcg gctcctgcgg 180
gaacgtacca gccagaccgt gcagctctcg atgttcgacg ctggtatgga tttgaggaac 240
gagcggccgt tgccgccgga agtcccggac gggtacatgg ttccgaccgg gaagtacccc 300
gaccgtctga acggaaagtg ggatggcctg atttttgacc cgacaatttg a 351
<210> 66
<211> 405
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(405)
<223> ICBIDGAJ_01367
<400> 66
atgaccgatg aaaagaagtt tgaggttcgt gcagagatta cggctcggct gacccagcag 60
gatgttgatg acatcatggt ttctgcgctg gagggcggca tcaactactg gtgcaggcgc 120
gttgttgtgc agggcaagta tcttggggag tacgcaagcg accagatttc tcgcggtggg 180
cagcttgccg tttggctcga agaaccgttt gaggatgaca agacttgtta tatgctcgat 240
ctcgacaagt tcctcgctgg atttaagcag tggctcgaaa attgctacgc caactgcgat 300
gttgtggaca gcacagatgg ttccgttgac tgcggccaga ttgatgccac ctgtgcggac 360
gagattgtcc agcacgcact gtttggcgat ttggtattcg gctga 405
<210> 67
<211> 366
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(366)
<223> ICBIDGAJ_01360
<400> 67
atgaagaacg agtacatcgt agcgattgac tacagcgcaa actacaagcc gatgaccatt 60
gattacaaga tgctgaaggc ggagaacctg ctggatgcca tgaacgaggc cgagcagtac 120
atggacaaag aaacggtcta ccttctcaag atcatgaagc gcagcggggc agctcacaaa 180
gtcaagggcg tggatgcacg agaagccacc tacaccgacg ttctcaccaa ccggggcaat 240
ggctggcaca gcaccgatgt agctcactgc gagcagcctt ggatgagcca gatgtggatg 300
tacagcaacg gttttgttga cctctactac tgcgaggaag tccgacctgc ttgtacgaca 360
tcctga 366
<210> 68
<211> 219
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(219)
<223> ICBIDGAJ_01362
<400> 68
atgaaaaacg agaacatgac cgctgaggtg acccgtgagt gggagaacga cccgaactgc 60
ttcctgcgga tgctgaacag ccccgcacag cagcggagcc gcgcagcccg ccgccagaag 120
gatgccgacc gggagcactt caacaatgtc ctgaacgccg ttgccatcgg cgcagcagcc 180
ttcgccgtca ccctgctcgt tatctgcttt gttctctga 219
<210> 69
<211> 336
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(336)
<223> ICBIDGAJ_01363
<400> 69
atggacaacc agaacatgac ctatcccgaa ctgcgggacc tgttcgttga acacaacaag 60
acccagcttg caaagccggt gagcgcctgc atcgtatttg ctgagagcaa ctggcctgac 120
caccattacc cgctgcgcag ccgcacctat gaggtcagca gcgacaacaa ggctttccgg 180
tcgagctgct gctccaccag cctgttcggt tcctgcttgg atggcaccga ccagatggtt 240
cgcctcgact ggtacatgaa ggacttcggc aacaagggcg gctgggtcgt tgaccactgc 300
tacctgaagg agaacagcga tgaatccgat gtatga 336
<210> 70
<211> 453
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(453)
<223> ICBIDGAJ_01074
<400> 70
atgaaatctt tcaaacgatt tttgactcct ctatttattt gtctattcgg ctttttatta 60
ttgaccggtt gtggtagttc aaataatact cctgctcagt cccaaaagga tgccgtgctt 120
gctgcactta atgcagctcg caaatcaaac aatgtaaatg ttctttctga ggacgatcag 180
gcagatatca ttgccgcccg gattgccaac gccggaattg attattactg cggaaatctg 240
acaaaagaac agtttgaaaa agagttttat agtgctggta tgacaaaaat caatggaaaa 300
tacttttccg aaatctatac tggtactatc attccaacaa aatcctctga tttttataat 360
aaagaaatct cttatggtag cgcccagatt gttggtatcg caattagaca gtataaagaa 420
ttcagtttca ccgtccttat ctcttatccg taa 453
<210> 71
<211> 636
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(636)
<223> ICBIDGAJ_01368
<400> 71
atgagaacat tgagagagcg cgatgcgctg cttgaagaat tgtggaagcg gttcggggat 60
gtccctatgg acccctccac cgaaacgatg gaggccccgt ttctggattt cccggcagga 120
accagccgcg ttgacatctg gcgctggttt gatgaacggc atagcaaggg cattgcctac 180
ttgctttaca acgaggatgc ctctaacgcg gcaagcatca cgagcctgct gcactgccag 240
aagctctgca cggaatgcga ctccgaaacc tgcgtgttta acccgcaggg catctgcatg 300
gctccgttcc tgaccgggag gaagccgggc gtccacgacg atggctgcac cgattactgc 360
ccgaaaccgc tggatggctg tgagccggtc cgctcctact ccgaatatga gcttcggagc 420
tatgaggagg acgtgcggga atatatctca cagttcaccg atgaggagct tatggaagcc 480
tatgagcttg accgaacgac gctcaatgcg ctcgccccgc gtgcggcggt cttgatgcgg 540
aagtatatcg acaatgacga tagctggacg taccaccgtg attatgccat ctcggaggcc 600
gtcagcgagt ataaggagga caaaaacaat gcctga 636
<210> 72
<211> 309
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(309)
<223> ICBIDGAJ_01369
<400> 72
atgcctgaga aaatgatgcc ctatgcgctg cggatgacgc tggcagtgct tgcaaatagg 60
ccggatgatg cccgcaacat ctctgctgag tgcgtcactg cgatgaccaa ggagctgatg 120
ggtgttgcaa gcggttatga tctgatggac ttcccgttca tggttgctgc cctgcggctc 180
accgcgacct cgctggagtc cctgctggac gagcatggca aggggattgc tgacggcatc 240
gtcgccaaca ccacctgcat caccattgat gcttccgagc tgaagcgtca ggctaaagag 300
gaggagtaa 309
<210> 73
<211> 744
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(744)
<223> ICBIDGAJ_01073
<400> 73
atgaaaagaa ttatttcatt aggacttgtt ggtatactta tctgttccgc tctcattggt 60
tgtagtgagg gaggtactcc agaagtaccc gctagtactt ctattgcttc ttcttccgca 120
tcatccgaac cttcccctag tcagcctgca tctagtagtt cctctgcacc cgtatccagt 180
tcaagctcat ctagtagtat cccgtctgaa aatccttctt ctagttcaga gagttcttcg 240
gtttctgagc ccccctcttc ttccgaagcc ccttccgaaa gccctgcttc ttctgttact 300
gagaaaaagt ctatctctgt aagctggaat gagaattata tccgctgtaa ggatgttgtc 360
actgacagcg ataagcaggt ctatgttccc ggccaaggct atacatgggg atatcatcac 420
tactatttag atatcatata taatatcacc aatacgggaa attgcccgat ttctcttgga 480
aatgatgctt tttctgttgc atgggatgat gaacctttaa ccgatcattt tgtatatctc 540
aatgcgcaac taattgaccc cgtcaaatta tccgagggtg aatccgcaat ggtcgccgta 600
cgttacccta tcagtgcagc aaaatatgaa gagttttcag acctgtttgc tattgctccg 660
cacaggataa tccatactgt cacatttgaa gaaagcaatt ttacatatac ttatttaaca 720
aagttgtatt cctcgaatat gtaa 744
<210> 74
<211> 225
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(225)
<223> ICBIDGAJ_01777
<400> 74
ttgtatatga atttaaaggc agagatggca cgtaacggga ttaccaatga gcagcttgcg 60
aatggaatcg gaatcaatcc ggcaacgatg tcagcgaaat tgaacattgc ggggcgaatg 120
cgcttggatg aagcgcaatg tctccgggat aagttctttc cggagatgac gatggactat 180
ctctttggag atgtccagcc caccgacccg aaaaagagcg catga 225
<210> 75
<211> 219
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(219)
<223> ICBIDGAJ_01776
<400> 75
atgaagtatg aagaaattat ggcggccata aaggacatca atggcccgtg gagcaacgcg 60
gcctgcatgg gctactgcct gatcgcaatg cgccgggcgg ggctgaggcc tacagcacag 120
cgccgggtgc tgctggcgct ggaaggggtg ttcgacgatg tgagtgtgga ggaggccgag 180
aaggccgaga aggccggata tgccaataag gaggagtaa 219
<210> 76
<211> 339
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(339)
<223> ICBIDGAJ_01775
<400> 76
atgatcgtga tcccggcgaa gaaccgggca ttcaacatga agtgtgatga tggtgacagc 60
atgaagctgg agaccctgca gaagctggtg ggcgggccga tcaagccggt gcccgccttg 120
ctgagcgccg agtgggcgcg ggagaaggac gtggacggca ttctgctgct ggtgaacgag 180
gaagggctga tgaaggagcg ccccctgacg aaccagcgcg ccagtgagat ggcggcggca 240
gagctggtgg gcccggcagt cgtggctgca aagcgcggcg atgagctgat cggctttgca 300
aagcctgtgg tggagaccat ctgcgccgag tggctgtga 339
<210> 77
<211> 267
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(267)
<223> ICBIDGAJ_01774
<400> 77
atgaaaaaga agatcacggg cagcgtgctg agcgccggtg ccattgtgct gggactggct 60
gccgtaggct gcggcggggc cattgagaac gcggccaatg gctgggtaat gctgggctac 120
acgctgctgg ccatcgtgct ggggtgtgca gccttggcgc tggccgggct gggcctggtg 180
gcagagcagc ggaaggagcc gcagaagatc cacaaagtgc cggagaacac ggtgaagaag 240
gccgtctgcg gcagaaaggc ggggtaa 267
<210> 78
<211> 294
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(294)
<223> ICBIDGAJ_01773
<400> 78
atggtacgga ttgaaattaa aaagacagtc aagggtcaga tgatgctggc ggtggaagct 60
gagcatgaga gcctggacga agttctgaca tgtgctgccc ggtgctttgt gggtgttgca 120
cggaagcttt taggccccat ttctactgac ccgttatttg ccgacgaggc ggcgaaactt 180
attaaggatt tgctgacgga cacggaaggc tttaaggtaa cggaagggta cgagggcaaa 240
gaagcaaaat ttattgccgc gctgaacggt atgaatgcgg gggaacagaa atga 294
<210> 79
<211> 360
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(360)
<223> ICBIDGAJ_01772
<400> 79
atgacgctgg aagattacaa gaacatcctg cggacgggaa cgcccagcga ccgggcgcgg 60
gccattgccg aggccgggaa cgacaggagt ctgaccgacg aggagttcca cgagctgacg 120
gccatgatca agggcgttgt gcggcccggg cggcggaaga tgaccccgga cgaggcaaag 180
ctctgggcgg aggtgagccg gatcaacacc cggttgaagg acgagatggt gaacgcgggc 240
tttgcggtga gggccctgcc cggcgacctg caggaggatg caatcaacgt tctttcccgc 300
acggtgagcg ggatgctggg cgacctgacc gccatgatgg cagagaccgg ggaaccctga 360
<210> 80
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_01771
<400> 80
atgaaaacga agatgagcct ttcggcagag atggacctga cccaggacag cgtggtgcag 60
ctgacctgct ggtgcgggca gatcgcctta catgagctgt gggggctggg ccgcacccgg 120
cttgaccgga tcaccagacg gaaggagctg ctgggcagtc tgaagggcac ggaggtgaaa 180
gtgtga 186
<210> 81
<211> 1938
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1938)
<223> ICBIDGAJ_01770
<400> 81
gtgaccacct atatctgcaa atgcggacgg cgagtgaaga aatccaccga tgccagtacc 60
actggaaacc gcctatctgg ttacgcaccc ggacatgagt gctggggatg cccctatgcc 120
atgccatacg gagactttca atgggatgaa agtgctagaa ctgtcagccg ggagactcgg 180
ggctacgagt gccggatgag caagaccctc acttatgcgt cagagttcgc tggctctatc 240
aaggataaat gcacctgtcg agtgcatagt ctggacttcg actttctgtc tcaggtctcc 300
gcatggatca aagacactta tccagacaga gagattttcg gctcattttc caaagatatt 360
cgtgcatcgg actatggatc tgacggccgt tactgcctga ctatcacctg cactcagaat 420
ctgaaaggtg ttgccgcaaa aagagagctg tttggtcagt ttttcactcc gaatggcagt 480
cgcaaggaca tgacaccgca gcaggaaatg gaaaagattc ttgccgacat caaaaaagca 540
aaggagattc tctcatgtgc acctgcccag aatgcggatg ctgctgtgac tacggcagag 600
aatgctgtcc cgactgccac agcggcaacg ccgaccatct cggagagcgg ggcggatgca 660
agcgcatcga cccccgcgac atccctgcag aactgcgaat cggcccctgc cgcatcggcg 720
ggcggttctt ctgtatcaac agctggtgcc atgcaggaca agcccttaac caccgtgccg 780
gatgcgatgc gcccggcgtt tgattattcc ggcctgaccg accagaccgt ggaagacttg 840
cattttgcgg agaacgaata ccgccacggt aagcagatgg ccgagcgtgg ccttgtgcac 900
atgggcaatg ccatcgccgc cgcccatgat gcactgtgcg gcaccgttgt ccaacaattg 960
gacaacggcc agttcgcaaa aaaagaggat acgttccggg catggtgctg ctctatcggc 1020
atcaccaagt caaccgccta caacctgctg caggtctctg ccctgatgga cggcagcagc 1080
ccccgccagc gggccattct ggaagcccta ccgcccaccc tgctgtacgc cgtggcaaag 1140
cccagcgccc cggcagagct ggtggagcag gttaagagtg gtgacatcac caccaacaag 1200
cagtatcagg aagcccttgc ccagatcaaa gccgagaaag agcgcgccga tgctgccgag 1260
acccgcgagg aagaggcgtg gagcatggta agtaaggcac aggacgaagc tcagaccgct 1320
aaaagcaatc tggaagttgc ccttgtagac ctgaacggcc tgaccgagca gaacgccaag 1380
ctccagcaga gctaccacga tgcagacgag agccgcattg cggccaacct ccagcgccag 1440
aaggccgaag gtgagcgcga cagggccgaa gagagagcaa aaaatgccga agacgctttg 1500
aaaaagcagc ccatcactgc ggtggtggac aaggaagagg tggagcgtca ggccagaaag 1560
ctttttgccg atatggcaga tgaagaagtg gaccgccggg cacaccagca ggcatacagc 1620
attgcggccg acatgacgga agagctgaag gccgacaagg ccaggctgca gaagaacatg 1680
gacgagctga agcagcagct tgccgaggcg caggctgtgg ttccggctga tctggtcgcc 1740
gataaggaga ccgccgacag ctgttacctg aacattgatg gcatctgggg catggccctg 1800
ccctcgttcc agcggctcgt cggcaccggc gaggacttca accgcgccgc gggcaacctg 1860
ctccagctgt gtgaccacat ccacgaagag ctggtcaaaa tgaccatcgc caacgataag 1920
gagacactgt atgactaa 1938
<210> 82
<211> 1290
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1290)
<223> ICBIDGAJ_01779
<400> 82
atgaactggc tatatattac aagcggtgtt gccgttattt ttctcatcat tggctatatc 60
tgtggaaata aagtcggtca taaacaagaa cttgattcta aagaaattaa ttcggcaaga 120
ctcagcagtg aaattcaaca aaaagagcag tccattcagc aacttaacga ttctatcgaa 180
aaatatcaaa aacttgaaag aagtgctgaa aacaatttga gtcttgaaac gcaaaggctt 240
ttaaaagacc gagaagatca gctttctggt cttgtccgag cgcttgactc aagggagaaa 300
aaattagaca gtcgagaaaa ggaactagaa cacgcgaaaa cagagctttg cgatatgctt 360
actactgctc aaataacaac acctttcttg gccaagcaat tttcagattt tatgtatata 420
aatgacttgc ttgatgctga ttacttggaa acgaaatccc gtcctgcttt taccgcagcc 480
gagaaagttc gagagattgc cgctcaaaag cggttgcttc aagaacagtg caaattacag 540
gagtatcagc tgaatctgta tgaaagttct tttccctggc tggcagagtt caaagaaatc 600
agcacagaag atttgcagca actcaaatcc gtagattctg caccggacag tgaatatagt 660
tctttgagaa attggctttc tccgcaggaa tatcagtcct tgtcgtctgt cgaaaggctt 720
caacttgcat tggatagata ttcaaagcgt caaaaatcta attggcaaat tggcattgaa 780
tacgaacgtt atgttggata ttgctatgaa aagaaaggtt atcgtgtacg gtataatgga 840
gccatggaag ggcttgaaga tatgggacgt gatcttattg tttccagaaa taagagtatg 900
ttcgtaattc agtgcaaacg ctgggccgta gagaaaacca ttcacgaaaa gcacattttc 960
cagctatttg gaacaaccat tctccaaaag ctggaacatc ccgactataa tgttggcggt 1020
ttatttgtta ccactacaac attatccgat ttggcaaaat cctgtgcgga atatcttcat 1080
atcactgtta ttgaaagctt tcctctgaaa gcgtaccctc ttattaaatg caatatttcc 1140
aggaatggcg ataaaatcta tcatcttcct ttcgaccagc aatacgatcg cgtaattatt 1200
gatcctgatg atggagattt ttatgcttcc actgttgaag aagctgaaac caaaggtttc 1260
cgccacgctt ggcgatggac tggctcataa 1290
<210> 83
<211> 1224
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1224)
<223> ICBIDGAJ_01855
<400> 83
atgaagaata tcctaattgt ggaatataca atttatcttt tttccttcgt tgatgctcgt 60
tttgaaaatc cacttctgag ggaacgtgca gcaatttgga cgggctacgc tttcctcagc 120
ataattcaaa tattatatgg atatgttgtg gaatatgcaa aaaatcgcaa agtaattcgg 180
gatttgtcta tcacaaaata tttgtggttg attttagcgg taatgggtgt gcagctgctt 240
aataactaca cagatgtaaa agagtggata gttatgtttg tgtttttggt tgtggttttt 300
tcgacgggct gtgaatttgc acgttattat gggttgaaag agttattatg gatcaatttt 360
ttgattccca atatagcgac tcttttaaat tatatgataa ataaaattaa tattaatgag 420
aatatagccc agatgaactt ggcagcgttc ttctctagca attactcact gagaactcga 480
ttcaatttag gatttccgaa tcccaataca acgggaagtt tggcagcagg tttggtgatg 540
atagctctcc cactattaac tttcctaaaa acaagggaaa actcagccat aaaaaagatt 600
cttatttaca ttatgatgct gtttgatttc ttgattttag ttgaaagcgg ctcaagaaca 660
gctgtgattg ccgtagcagc tggatattta ttgtatgtat tcttcgtgtt tattaataat 720
ccacgatggt tttccaaaaa aatgcgtcag actcttttat atctgatgtg ttcttttagt 780
tgtgcaggga tgtttttaat tgcaaataaa tttatgacag tttacttgga ttcgggcaga 840
aatcaggcat atcagatttt gacatatttg aaaggaattc gagtatttat cggccttgga 900
atattgaatc caggtgccgt cgataaactt gttatcgatg gacaacctct ctcgggacat 960
ttggataatt actatgttta tcttctaatg acaattggaa tcgtaggttt ggttttgttt 1020
tttgcctttt ttggaaagct ttttcagaaa attcggagga gaacagatga ttcaatgaca 1080
gcagcagtat tgagttgttt tgcgtttaat ttgttgtacg gttttggaga gacaagtgtt 1140
ctctatcatc aatttccaac atcacttata atgtttacga tgtttctgtg cgttgccatg 1200
ggagaaaatc cgaatagaac gtga 1224
<210> 84
<211> 336
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(336)
<223> ICBIDGAJ_01388
<400> 84
atgagtacct caaagtgcga gatgtgcgga cgggacatac cgaacgccaa gaaccgccag 60
aagttctgcc ctgactgcgt aaagaaacgt caggccgcac aatcccacaa atcttatctc 120
aagcaccgcg agcattatct ggaacgcagc cttgctcaag ctgaacgtcg gaagcaggaa 180
gcgctggagg aaaggatgct ggaggaactt ttgctcgcaa aaagaccgga accgaagtac 240
agcatcattc aggtggtcga aaaggcaaaa gacctcggca tcagttacgg ctggtgttcg 300
tatctgcttt cggtcggaaa agtctgtatg gaatga 336
<210> 85
<211> 123
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(123)
<223> ICBIDGAJ_01386
<400> 85
atgtggactg aaatgtctga tgcagccaag tggctggcag ttggagctgc gattgtcgcg 60
gccattatcg taactgggca gacgtacccg ttgtggttct ttctgattcc gatgatctgt 120
tga 123
<210> 86
<211> 213
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(213)
<223> ICBIDGAJ_01385
<400> 86
atgacacgta aagaaatgtt tgacctcaga attgcaagtg atggatttcg ttatgcggtc 60
agaaaagcgc tgtttgaatg ctccaaattt ccgccctgca ccgagcgaat gatcgttgag 120
ggaagactgg ctgaagcgct gtatttttca gagcggatga tggaaaaaac gtacaaagac 180
cttgaaacgg aggaaaaaac taatgtggac tga 213
<210> 87
<211> 348
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(348)
<223> ICBIDGAJ_01382
<400> 87
atgcctgaaa tcaagatttt cgatgccctg cctgaagaag aaatcctcgc ccagatggcg 60
gaagaatgcg tagaagcgtc caaggcggct ctgaagctcc gccgggtgcg ctgcggtgtg 120
aatcccacgc cggtgtctga gaaggacgcc ttcgagaatc tggtcgaaga gttggccgac 180
atctaccttt gcagcatcgt cttcttcggc ggcgagctgg atgacaacga cccctgcaat 240
atgtgtgatg cggtcggcga ccggatggtc gagatcatgg agcagaagct cgcccgctgg 300
aagtaccgtt tgatgaagaa ggaggatgtc gatgtccctg aagaataa 348
<210> 88
<211> 261
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(261)
<223> ICBIDGAJ_01380
<400> 88
atgaccgaga agtccgaatg gcagttcctc gttgattacg tcaaggatga cacgacagat 60
ttctacaacg atgcctgcca gaaccagctt gtagccttgt ggacctcgta ctgcctgcat 120
aacagcctcg atgtcgatac agcgatgtac gatgcagttt tgatggattt gttcaacgct 180
ctctccgatg aacagaaagc cgaactgcac tgcaccggct tctcggagtt tgatagtatg 240
atggcccagt ggcttgtctg a 261
<210> 89
<211> 360
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(360)
<223> ICBIDGAJ_01381
<400> 89
atgagcgaca tacggttagt taatgtagtg cccatcgtca acggatggaa cgatgcggcg 60
aagaagaatc tggaggaggc caaaaccttg atggcctccg ggaaccatct cgactacaac 120
aagggtgttg tcaaggaaag cgttgcgaac ctcgtttccg gatttgccga tgacctgatg 180
aaagctcctg ctgttgaccc ggagagccga cggcctgtat ctcattgggt tttgcaacgc 240
agtgtcgcgt attgcgaaag atgccgcaaa gggtacagaa ttacgaatgg aggagcgaac 300
gtcttgacgt ttagctattg cccgaactgt ggtgcaaaga tggaggataa caatgcctga 360
<210> 90
<211> 648
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(648)
<223> ICBIDGAJ_01540
<400> 90
atgggtttga taaccttaaa ccttaaaagg gtattgaact ggaattttat atttatgagt 60
gcggtagcag ctatcttcgg catgatctct ctgatgaact ttggggatat ttcagaaaac 120
attgtatttg gcgttgatat aaagtatttt atgcttgatg gatacctgtg cttatttatc 180
ttttttgccg gagaaataag caaggatatg ttgcagcaag aaaaaatcac aaagagaata 240
gaatggaaac ttgctaatgg tattaaaatc tcaagtattg ttaaggagaa tctgctatca 300
ctatggattg gaacgctgat ccttttgttt cctctacttt tgataatttc cattcgcctg 360
ccaaacctta tcttgttatt aggcacctat tttctgatcc ttagcatatt gtattcggca 420
tttataaatg ttttgattct ctggattaga aatatgaact ggtttaagag tattcctatc 480
tttgcaacac tgcttcatat tttgctggtt gtcttaaaat gtgggatatt tatgaaaacg 540
aataatgtgt gggtgttgct actattttct ccagtgagta taatagtttt gactgcgtgt 600
ggtttatgtc tgatgactaa agaacggatc gtatcatcat attactaa 648
<210> 91
<211> 705
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(705)
<223> ICBIDGAJ_01541
<400> 91
atgagtaaca tgggaaaagg cgcaggctac tatcttacca gaagtaaaag cctcctaatt 60
gatactgcga ttgttgccat tctggcgatt tttatgagct ttgcaatgca gatggacacc 120
ttgcagtcta agggagatga ttatttagtc ctaatgctct atgcggttat ttttggtctt 180
acctccctgc aatccggtgc tatgattgta gatttgacag caaaggataa gttaagccgg 240
agaattgaat tttttgcagc ttctggaatt gcagtaaaag agattataaa acagtattcg 300
atacagattt tccgcttttc tggtattatc ccgttctttg tttttatgag ttgctattac 360
tttaccgact ggacaatgag ctttgggcgg atcgtatgcg tttatcttag tattcttgta 420
cttagttttt gtgagattgt cgctttgaat atcattgtac tggatgtgaa acgagtaaaa 480
ctgttcaaaa atgttctgtt ctttggtaat tttgcactgg tttatttgat tgcgatgtcg 540
gcagaacaga ttacagagtt tgtgaatcaa catcatatag gaattgacta tttgattatt 600
gtggttgatg ttgcactttg catgatgttt gtactattaa gtttctttaa ggctcggcac 660
atgagcaacg aaacagttat caggagggat ggcgaatggg tttga 705
<210> 92
<211> 513
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(513)
<223> ICBIDGAJ_01780
<400> 92
atgtttacga gcaaacaaaa tgaaccagat tatacgcctc cggaaattga accaggggac 60
attaacagtt atattacaaa ccgtctggat gatcagatca actggtacga taaaaaatct 120
cagaatgcac aaaagcgcta taagtgcttg caactgaccg agcttgttat tgccgcagcg 180
attccgctgc tttccagtta tactgttgga tgttcccaag ttgctttcat ggtaggtgtg 240
ctaggtgctg caatcgccat catcgaggga atcgagcgtc tttatcgcta ccatgaaaac 300
tggatcgaat atcgtgccgc ttgtgaggcc ttgaagcacg aaaaaagcct ctatctgatg 360
aatgcttttc cttacggaac ggatgaaaca aaagagcagt tgttcgttca caacatcgaa 420
aatttgcttt cctctgaagg cagcaaatgg aaatcttcca atgcaaagcc tgtcacagat 480
aagagcaaaa ctcagtcggg aaccgcttcg taa 513
<210> 93
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_01781
<400> 93
atgaaatttc aaaaaaaacc ggtcattatt gatgcgtacc agactgacaa agatgtgtat 60
attgagacgc tggagggtgt gatgcatgcc tcaccggggg attggatcat taccggagtc 120
aacggagaaa agtatccctg caaaccggac atttttgaaa agacttacga agcggttccc 180
gactga 186
<210> 94
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_01373
<400> 94
atggctcgca aggaaatgta cactctcaag gttgacggcc gggtggtctg gaccagcaac 60
cggctcccgt acatgaagaa gatcgcaaac gaaacgcttg agctggacaa cggcttcttc 120
gctgagattc tgcgctacaa caagacatat tcgacccgct tctacaacac gaagtggaac 180
cgctga 186
<210> 95
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_01372
<400> 95
atgaaaacct acatcgtcac ctatttccgc cacaaccctc agctcaagaa cggaggctac 60
acctccacct gcaaaattga ggccgcgtcc atcgcgtcgg cccgcaagaa ggctcgcgag 120
ttctgcgaag gcgcggttta cggtagccgg gagctgctgg atgttcagaa ggaggtcaac 180
ggctga 186
<210> 96
<211> 444
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(444)
<223> ICBIDGAJ_01371
<400> 96
atggtacgcg cagcccttgc tggagcaggg aagacccaga aagagttggc cgaacacatg 60
ggctggaccc cgcagaacct cagcgggcgg ctgaagaaca actcgctcac cttcgatgag 120
ctgtcaaagg ctctgcattt tgctggttat gaggtctcca tgagtgatgc caacggtgcg 180
ggcctcccgg agctgggcaa cagcaccagc cccgccgtag cgcagaccgt agacggcgtt 240
cgatatgaca cccgcaaggc cgaatcgctc tgctcgaata aggccgcgat gttcgaggac 300
ttctatgtgg agctgttcga ggatgccgct gggaactact tcaccgtcct ctaccagctt 360
tctggatgcc agcatcatac catcaccccg gtaagcgccc gtgctgccca gcagttctta 420
gagaggttcg ggagcagagc ataa 444
<210> 97
<211> 519
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(519)
<223> ICBIDGAJ_01370
<400> 97
atggaaatca agcgcggcga catttggtat gtgagcaagg acaactacac cggctgtgag 60
caggcggcgg gacgcccggc aatcatcgtt tccaacgaga agaacaacgc ctgtgcagag 120
acggtagagg tcgtatacct gaccacccaa ccgaagaaag acctgccgac gcacgttctc 180
atccgcagct ctgaacgtga aagcactgcc ctctgtgagc agattacgac cgtatcggtt 240
gaccgcctgc tgggctacaa gggccacctg accccggcag agatgaccaa cgtggaggtt 300
gcaatgctga tctcgctgga gctggaagtt ggaaagcccg tagagaaaat cgtggaggtc 360
acgaaagaag ttccggtcgt ccgggatgtc aaggtatcta cgcctgcgtc aaatccgaac 420
atggctgcgg agctggccgc agcgaaagcc aagtgtgaaa tgctccagac catgtacgag 480
agcctgctga atcgggttct ggctggaaag gcaggctga 519
<210> 98
<211> 735
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(735)
<223> ICBIDGAJ_01377
<400> 98
atgaaaaagg tcgttagtcc gtgtttctgc aaggtctaca cccgaagcgg caatgaagcg 60
actgcgcggg cattctgcga aatccagttt gagaatggca gactcagtat caccggcgtt 120
atcggccctc tgcgcagcgg tggccatcgt ggctgcgctg gtcagtgcgt tgatgaaatc 180
cgcgaaggct gcccctgcga tgaatggacg caggaaatgc tcgacaagtt ctgctccatc 240
tgggacgagt ggcatttgaa cgatatgcgt ccgtactgca agcaccagaa ggagcttgga 300
tgggacaagc tggccgtcac gcctgtcacc ctgtaccact atcggctgaa cagcaaaacc 360
ctccggcggc aggaatccat gaagaaaagc tcatggaaga tgctctgcga tggcatgacc 420
gctgctctga gcgatgacca gattgaagtt gccaaattgc cgtacagact tacgctccct 480
cacgaaatct ctggcgaggc ggctttgtat tacgagccgc agaagccgct ctaccccgga 540
atggctggtg cgaccgaaac gaagaccctc ggatggctcc atcccgatga acaccccgat 600
ggcattctcg gcaagccctg cccgatttgt ggctaccagt acggccacgc atggcagacc 660
gaagaagtcc cgcaggaggt tatcgactgg ctgttcaacc tgcctgaatc gcccgtcgaa 720
ccggagtggg tgtga 735
<210> 99
<211> 234
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(234)
<223> ICBIDGAJ_01376
<400> 99
atggaaagga actggttgct cggtgatgac ctcgccgcct gcgacaacct gcttgacggc 60
atcacgttcg atgacatcat cacgcaggtg cattgcaact gccgcaacat cacgcccgat 120
gctgttcgca aggaagtcga tgacctctta aaactgcggc tcgccgatat gcgggagctg 180
cttgagcgaa acatcgacaa gattgccgaa gaagcacgaa aggggagaga gtga 234
<210> 100
<211> 279
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(279)
<223> ICBIDGAJ_01375
<400> 100
atggcaaaga tcatgttggt catgacccat gaggaggtcg atacgaacat cgcgtacagc 60
ctcatctgct tttctcgtta cggcagcgca tgggacaccg gtcgccgccg tcgggcgtgg 120
ttggcaaact tcaccgagga ggagcgccgt gcggcctgtc ggctgttcaa acaggcgcgt 180
ggctggaccg ttggccgagg cgttcccgat aaggtcacga tgaccgagaa gacattctgc 240
ctgtggcgca agctcgctga gttttgcgct tctatctga 279
<210> 101
<211> 162
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(162)
<223> ICBIDGAJ_01374
<400> 101
atggcattgt acgccgttta ctatcagacc ggtgtttcgc cccttgatgg cgcaccgctc 60
tgcaccatcg accttgtgac gcaggtcgag gccaccgcga ttgccaagca gcaggagctg 120
accgatgccg gtctggttgc ttggcatgag cagattcagt aa 162
<210> 102
<211> 660
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(660)
<223> ICBIDGAJ_01379
<400> 102
atgatggaca aaatcgtggt cacagcggcg gacatcgaaa agctccttgc atggcgggat 60
gagcacaacg atctggttcg ttcgatgccg gtttccctgc gagaagtgga aatccagatt 120
gtcgagagtg gcatctccat caagtgcttc cgctctgaca agaagctgaa gctctacatc 180
gacagcccgg cccggaagct cggccacgtt gtctttgctc cgctgggcaa cggcctgtgg 240
aagaagaagg taagcacgct tcctgcggac tgcaacccca ccgaaaccga acagggcgct 300
ttgactgtgt atggctccct gatggcgctg atgacgtatg gaacgggtag catccgtggt 360
ggcatggcta ccacaacctc gaaggctcct gctggacgca aaagccctac aaagccgcac 420
accgccagca ccacatacat cattcactcg gtcggaaaac agcttacagt ggttcccaga 480
ggccaccatg caagcccggc ctgttccttt accgtaagag gccactttcg ccactacaaa 540
agcggcaaga cggtctggat tgcggagtac cgcaagggga ctggccgcag ccggggcaag 600
acctacaaga tcggaggtga tctggatgac cgagaagtcc gaatggcagt tcctcgttga 660
<210> 103
<211> 1194
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1194)
<223> ICBIDGAJ_00164
<400> 103
atgaatttgc cgttggtatt ggaaaagaat acaactccgc agaattggaa tacacggcgg 60
gaagtgctgc tcgcgttgtt ccgctcgcag gagtacggca tccggccgga agttccctat 120
gaacagaccg aacacctgcg gtcagaagag tatctgccaa aatgcaaggc catccggcag 180
atctgggatg tctgtctgaa aacgaagctg ggaatcctgg aattccccgt ggtgctggtg 240
cgcccggagg gaacacagaa gatcccggca gtcctgttcc tttgcaatca cgaaaaaact 300
gcctctcccg ggccgaaaat ggggcctgac cagatggaaa aactgctgac caatgccccg 360
gaagcgtggc gcagggaggc catgaatttc ttccggaata tgccagccga aagcggcggg 420
ccgtcgctca ttgatatcga acaggaaacg gagcaggaat actggcctgc tgaacagatc 480
gtacaatcgg gccgggcagc cgtgaccttc tatgcaagtg cattgcagcc cgacgatgct 540
gcgcagtatc ccggcccact ggcaaagctt tttgggctca gtgcagatgc actgcctgcc 600
gatgcatggg gaaccctgga catctgggcc tttgggatga gctgtgtggt agacctgctg 660
gtaaaacacc cgggcatcga cccggcccga atctcggtgg gtggtttctc gcgcggcggc 720
aaggcggcgc tttggtgtgc ggcacaggat gaaagggtct gcggggtcct cgtcaatgat 780
tccggctgct ctggtgctgc cgtgtcccgt ggcaagcatg gtgagacggt gggttccatc 840
acggcagcat ttccccattg gttctgcaaa aattatcaga agtatgcatg gaaagaggag 900
acccttccct tcgatcagca ccagctggtg gcctgtgtgg caccacggct gtgttacata 960
accagcggct ctgaggatcg gtggagcgac cctgatgcag agtggaatgg tgcaaaaagc 1020
gccagttgtg cctgggagct cttcggggac gctcctctgc ccagccagcc gcctgccaat 1080
gactcgggat acctgactgg gcgaattgga taccaccgcc gcaccggcgg ccacgatatt 1140
acccgatggg attgggcaat gtttctgcgt tttttggatt ttcacaatgg ctga 1194
<210> 104
<211> 252
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(252)
<223> ICBIDGAJ_00399
<400> 104
atgatgctcg atttttttct actggacatg agtatatgct tgtttatgca aagtcagtgg 60
ccagtctttt gggaaataat gtatatttca gagaagaaaa accgggagca gctgaaatat 120
acgctgaata ccttaggctt caacaactat atggaactga ttgcgcaaag attcaagatg 180
gcttgcaaga tttttattca caccttccga aagatcatcc ggcaaaaaag ctttcacgct 240
ataataaagt ag 252
<210> 105
<211> 1785
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1785)
<223> ICBIDGAJ_02460
<400> 105
atgggcttac tcggatctct tttttcggca gccgccgata tcgcaaagga aactatcaca 60
gaaacaatga atcaaaatga aaccgaaaaa ttcattaaga taatgatgga gcgcgatgct 120
caaaacgctg aagcaaatga aaaactctat caagactggc tcacgcatga aagaagcaac 180
tattttgcgg ctaaaaagaa tactatcatt catgatgcct ttgatgttct gatggattct 240
tttgaggata ccggaaaatt tgatttttct gctgtggata gtttgagcga tgaactgaag 300
aacagcgata gctataagca ggaggcagct gatgttgtta atctatgctg cgaagctcta 360
gttaaactgc atcaaaagtg ttgtatttcc attcgatttg ttatgcagac aattcacaat 420
ttacagcgct tcgccgatat tgtccctagc attcgaggct tggatcgtca ttatgatgct 480
ttcttccctg ttgacaatgc cgattgcagt tttttgacag atttcgacag cattgcggaa 540
ggattagaag ctgccaaaaa tgattctgat aattatctcg cgatggttgg aagcaacagt 600
ccgttgtcaa ggcttgcagc tttgaaagat attttgaaat cggaagacta tgttgctgct 660
gtttccaatt tactttttgc cgatcaagag gttgctcctt atgcaggtat gaaaaaaatg 720
attctctgtc tctctatgga ggaaacagac gaagctaccg ctcttctttt ggatacatat 780
tgtacggtta ttatgaatta tttacggctt tcaacagcta aagaaaaagt cggaaaagat 840
aatcctttta tttctgcatc aacagagcaa atcctgccaa tcgatctttt gattgctcaa 900
tctattaaat cttcgaaatc tggtagcccg caggaagttg ataccaatct cgatgagttc 960
cttgaatatt atcctctgat ttgtacatct agctgggaag atcagctttt catacttcag 1020
aaagtttttg cttacctcaa aatgtattct caggagagaa aggttcttga atttttagtc 1080
aaaaacaata ttcctcgtac tgagcaaatt gatcgtcggt taaacttttt gaaaaatctt 1140
aatcaaaatg acattagtaa tgcggccaac agcatagagg aatttagcat tcagacaagt 1200
gataatgaaa ttgcatatga ttatcgattt atttcttgga cagtttcgga aataaactcc 1260
tatatgaacc ttttaactag cgaggacaaa acactcgatc ttcctatggt tgttgctgaa 1320
tggaacaaga aaattcctca aaaaaatatt cgctggagta cagatgctat gcaagtttac 1380
cttgataagt atctccatga aaattttggt gatctgtata caaccaaaat taaaaactgc 1440
ggtgcagtac tctcaaatga agtagagtac gagccttccg tctatattga agcaaccgac 1500
agcgctaaat atccgtggct ttcgtttgtt gttactggtg aacagcttac catgacacaa 1560
gtttccttcg ctatttatgc gttgtatctg cctacgaaag actcccaatg cactcaggcg 1620
gttgatacaa tcgaacagaa tcagaaatac caaaatcgac tgattacttt aaaacaagct 1680
cagaatccta aaatcaagaa ttatattgag tccatcaatg aaattctgat ttctggtctt 1740
gaagcatggc taaataacaa caatacttct agcatgtatg attaa 1785
<210> 106
<211> 369
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(369)
<223> ICBIDGAJ_01660
<400> 106
atggaaaagg gtacggagac ggtcatcggc agcggcggca cccgcctttc cggcgggcag 60
gcacagcgtc tggcactggc ccggacgctg gcccatcccc gcccggtgct ggtgctggat 120
gacccattct cggcactgga ccgcagcacc gaggatgcga tctttgccga gctgcaggcg 180
tatgccaggg ataaggtggt gctcctgatc tcccaccggc tgtaccattt tccgcagatg 240
cagcagatca tctttatgga gggcggcagg accaccgttg gcacccacga ggcgctgatg 300
gcagcggttc cggtctaccg ccagctgtat gaaagccaga ccggcctgaa agggggagag 360
ggcgcatga 369
<210> 107
<211> 1452
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1452)
<223> ICBIDGAJ_01847
<400> 107
atgaaaaagc agaatggaaa attatcaaga gacgaatttg tatcgtttgc taaagcggtc 60
ctgaggaaaa attcattgga agaaaacaag cctctctatt ttgagtacag agtatccgga 120
aacagcaagc ttgcagaatc tgcaagaaga tttgatgcat ttgcgccaga tggatttttt 180
aaatatcaag ggcctgtgat tttcgaattt atagatagca aatcaaaaca gctggaaaaa 240
cgaatcagag cagtggcgga tgattataga aagaattatg acgcggcaac tatcttcatt 300
gtaaatgcta aaatatctct tgaagaatta gaccttacag tatgggatat cgatgagata 360
aacaaatgga tcaaagagta tccagctgag tatggtcatg cgtgttcatg gaatattgac 420
cgtaaaagaa ctacacaaaa caaagaaaag tttcaaatct ccgataatct gtacagagat 480
gacttatatc aaaaaaacaa tgatatttat acaaatgcaa tacgtatctg catcgaagag 540
aaaaagggcg ttgcaattgt gctgggtgcg ggtgtttcga aggagcaggg agcaaaaact 600
tgggatgaat tgctgagaga ttttcagaaa gagatcgagg agcagcatct tttggatgat 660
tccgaggcgg tttttcagga agttggaggg acaagtctta caacagctca gttatgcaaa 720
gacgtctggg cagatgagaa aacctttgct tggcaagtcc ataaaagtct atatgataag 780
gcgcgggaac tggatgtgaa taccgagtta ggggagattg cgcaactggc tcaaaaatgc 840
ctaaaagatc aaaactttag gattttaacc tataattacg atgacttcct tgaacagtat 900
ttagagtggt gtggagtaaa gtgttgttcc atgttcacaa cgaaggttag atactcaaat 960
ggtcaggtga gtgcggattt ttatggcgtg aatggacaac caaatcaaag cttacgactc 1020
tatcatgtgc acggattttt accaaaagtt gcaatgaaaa gtcaactgga tacacttcac 1080
ataagatcaa tctgcctgac ggaagctgac tataatatgc tttataatca accttatagt 1140
tggccgattg caagccagct ttctttcttc agagaaaata tttgtttgtt tattggatgc 1200
agtttaagtg atcccaatat ccgaaggcta ctggaaatca cagcgtataa tccgcctaag 1260
cattatgcta ttttacctac gatgtataaa agtagcgatg catctggtgt tgcgatgaca 1320
aaacagttca caacaagaga ccgacttcaa attgaaaatc atttttatcg cattggaatt 1380
aacattctgt gggtaagaga ttacagtgcg atacctgtat ggttgcacga tttgaatcaa 1440
tctattattt aa 1452
<210> 108
<211> 156
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(156)
<223> ICBIDGAJ_01396
<400> 108
atgtccaaga cgaagactga aacctatgtt ttgcgcaatt ctgctgatat cccctgggag 60
gggaagagaa caaagctctt tacgaacgcc tcaagaaaga gatcgcagac ggccacccgg 120
tggatgaata caacaacgaa gtgctctgcc gcctga 156
<210> 109
<211> 3393
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(3393)
<223> ICBIDGAJ_01556
<400> 109
atgagcgaca attacaccaa agtgcagcag gcgttccgca tcctgcaccc gcagctggca 60
gggtatgtct gccaggagct gcgccgggaa tatcaggaca actggtggca ggaagtcctg 120
atgaccctct ccgaccagac ccgcgacctg ccggacgaca acggcgatta cgctaccctg 180
atggattctc tggacattgc caactgcctg cgtctgttcg accgcaagtg gaacgacctg 240
ttcaagcgca aactgtccat cgactaccgc acctgggcca aggagctgat gggcgtgcgc 300
aacaagctgg cgcacatcgg cggtgcggat ttctcggagg acgatacatg gcgtgcgctg 360
gacactatgg cgcgcctgtg cgaagccttt gacgacgaag ctgccgagga gatccgcaaa 420
atgctgcgcc agctccgcta tggcagtgcc gaaggctcca ccaatgtcac cgaagtaacc 480
gccccggcaa agaccaaagc agcgcacacc gtcggcatta tgagcaaaac actttccggt 540
ctgcccagct ggcgggatgt catcgaaccg cacccggatg tggcgcaggg acgctataaa 600
aacgcagagt tcgctgctga tcttgcgcag gtggcacgtg gtgagggcgc gtttgaatac 660
cgtgacccgg tggagttttt tgcccgcacc tacgtcactg agggtatgac tggcctgttg 720
gtgcaggcac tcaaacgtgt ctccggcaag gatggcgaac ccgtcatcca gctaaaaacc 780
gcgtttggcg gcggcaagac ccacagcatg ctggcgcttt accacatcat gcgcggcagg 840
gtatcggcag accgcatccc cagcatcaag cccgttttgg cacaggcagg cgtttcggct 900
ctgcccaaag ccaacgtggc ggtgctggtg ggcacggcac tggaccccac ccgaaccaaa 960
cggcccatca atttccccgg catcaccatc aacactcttt ggggcgaaat ggcagcgcag 1020
ctggcggaat cggctggccg tccggaactg tacgattttg tcaaggatgc agataaaaag 1080
ggcgtttctc ccggcagtga agcgttgaaa aacctgtttg atgcctgcgg cccctgcctg 1140
atcctgatgg acgagcttgt ggcgtatgcc cgaaaattgt atggtgtgtc cggtctgccc 1200
gccgggtcgt tcgataactt caactctttc attcaggaga tcaccgaagc cgcacgcgcc 1260
agcaagaaca gtctggtggt ggcttctatc ccggaatcga atatcgagat cggcggcgaa 1320
gcaggaaaga acgcactgga aaccattgaa catacctttg gtcgtatgga atctatctgg 1380
aagccggttg ccgccaacga gggctttgag gtggtgcgcc gccgcctgtt cctcgactgc 1440
aaggatccgg aagcccgcga ccgcgtgtgc acggcattca gccagatgta ccagaacaac 1500
cccggtgatt ttccggcaga caccaaagaa gtggactacc gtgatcggat gatttcctgc 1560
tatcccatcc acccggaaat cttcgaccgc ctgtacgatg actggtccac gttggaacga 1620
ttccagcgta cccgcggcgt gctgcgcctg atggcggcgg tcattcatga gctgtggatg 1680
ggcagcgatg ccagcgccat gatcctgccc ggctccatct cgctggacgc acccaacgtc 1740
cgcgatgaac tgatccgcta tctgccggaa ggctggaact ccatcgtcaa cacagagatc 1800
gacggcaaaa actcggtgcc ttaccagaaa gaccagagca accagcggta tggtcgcatc 1860
atggcttccc gccgggtggc gcgcaccatc atgctgggca gtgcgcccac agtgcgttcc 1920
cagtccgtgc gcggcatcga ggcttcccgc atccgtctgg gcgtggtcca gccgggcgaa 1980
aacatcgcag acttcaacga tgccctcaac accctgcgcg gctcgctggc gtatctgtac 2040
accaacacca gcggcgaccg ctactggttc gacacccgtc ccaccctgcg caaaaccgcg 2100
caggaccgtg caacacaggt ggcggaagcc gacgtggaag aagaaattga aacccgcctg 2160
aaaaagctgc gcaaggaaga gccgtttgcg ggattgcacg tctgcccggc ttcctcgctg 2220
gatgtgtcgg acgatcaggc ggtgcggctg gtcattctcc gcccggatga gacctaccgt 2280
gccaatgcgt ccagtgccct ggcactcact gcggcagaaa atatcctgaa cacccgcggc 2340
acagcacccc gcatctaccg caatatgttg gcgttcgtgg caccggatca ggaagcagtg 2400
atctcgctga agcaggcggt gcgggacttc cgtgcgtggc gctcaattca ggacgacaag 2460
gaaacactga accttgatgt cacccagaac cgggaagtgg atgccaacct ccaccgcagc 2520
aacgataccg tggaagcccg catccgggaa acctactgct ggctgctcac cccggagatt 2580
gaccgcttcg tggatatgaa aaccattctg tgggatgcta cccgcatttc cggcggaacg 2640
gacagcatcg tgtcccgtgc ctcccgcaag atgcagcaga gcgaaacgct catcaccaag 2700
tgggcacctg ccctgctgca aatggaactg gacgaagtgc tgtggaagga tgctgaccat 2760
atccagatca agaagctgtg ggagtacctc tgcacttact gctacctgcc gcgccttgcc 2820
aagttcagcg tgctggaaga tgccatccgt accggcctga actcgcagga atattttgcc 2880
cttgcggccg gttacacggg cgaccgctat gttgaactgc ggtataacca gtttgtggac 2940
tgcatcaaca cctccgacct tttggtcaag ctggaccctg cccgcaagca gcttttggct 3000
gaaaaaagtg ctcccgcagt agttgtgcag cctacgcaaa ctgctcaggg cggcgaacag 3060
cccacccttt tcaaccttcc cccggatgct cccattgacc ccactgtaac cttgcatcag 3120
ccgccgacag cgcaacctgc cgctgttccc gctccgccca aaaacacccg gttctacatg 3180
actgccgagt tggacaccac ccgcatcaac cgtgatgtgc agcggctggt ggaggaagtc 3240
attacacacc tgctcagcgc agatggctgc aaagtttcgg taacgctgga tgttaccgcc 3300
gatgcaccgg acggtctgtc cacccccatt gtgcgcaccg tgatggagaa ctgtaaaacg 3360
ctgaaggtaa aagattttgg cgtagatgaa taa 3393
<210> 110
<211> 2781
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2781)
<223> ICBIDGAJ_01555
<400> 110
atgtctaaaa agctgattga agttaccctt ccgctggaag tgatcaatgc ggaagcagcg 60
cgcgaaaaat ccatccgtca tgggcacccg tccaccctgc acctgtggtg ggcacggcgt 120
ccgctggcgg cggcacgcgc tgtgatatgg tccagccttg tggacgaccc ctctgcccac 180
ccggaactgt accccaccga ggagacccag aacgccgagc gtcaaaggct gtttaccatt 240
ctggaaaagc tggtcaagtg ggaaaactcc aacgacccgg aggtgctgga cgccgccaaa 300
gcggagatcc tgcgctctac caataacaac ccgccggcct tgctggatcc ctttgcgggc 360
ggcggtgcca tcccgctgga agcccagcgg ctggggctgg aagcccacgc ccacgacctg 420
aacccggtgg cggtgatgat caacaaggcc atgatcgaga tcccgccccg gtttgccgga 480
cagccgccgg tcaacccgga cagccgcgcc aagctggatg ccgccggggg ctggcaggga 540
gcgcaggggc ttgccgccga cgtgcagtat tacggcgagt ggatgaagcg ggaagcgttc 600
cgccgcatcg ggcacctgta ccccaaggta aaagtacccc atgaacttgg cggcggcgag 660
gccaccgtca ttgcgtggat ctgggcacgc accgtcaaat gccccaaccc cgcctgtggc 720
tgtgagatgc cgctggcgag tacatttgtg ttgtccaaaa agaagggcaa tgaagcattt 780
gttgaacctc aatttgacta tgcaaccaag aaaatcactt atacggtgca caaaggaaaa 840
ggcaaagttc cggaagcacc taagactgca cgcggcgcaa aattcaaatg tatcatgtgc 900
ggtgaagtga cgccggaaaa ctatgtcaaa caggagtcca tgcaaggacg aatgggttct 960
gcactgatgg cagtggttgc agagggaaga aatggtcggc tgtatctttc gccagatgag 1020
acgcagtggc ttgtagcgga ttgtccaaag ccgaatgcag aatatcctga ccagtcgctt 1080
ccttatgacc cgcgaaatat atggtgtgtt aattatggtt tggatactta tgataaacta 1140
tttaccaacc gccagctgac tgccctgact actttcagtg cactggtagc agaatcacag 1200
gcaaaagcgg aagcagacgc ggtggccgcg ggcgttacaa acgaccatat tgccttgagt 1260
gcaggcggct ttggtgcacg ggcttatggt gaagcggtgg gcgtatatct tagctttgtt 1320
atcagcaaac tggcagaccg tggaagttca atttgtagtt gggattcttc tcgcgaaggt 1380
ctgcgaaata cgtttggtcg tcaggcaatt cccatggtat gggactatgc ggaagcaaat 1440
ccattcagca attcttctgg ttgctttgat aatatgctgg actgggtaac aaagtgtatt 1500
gtagaatttc cggctcagag tttcggtgag gttagtcagt ttgatgcaca aagtgactgc 1560
ggcttgcgga atattatggt gtcctccgat cctccctatt atgacaacat cggctatgca 1620
gacttgtccg atttcttcta cgtctggatg cggcagtccc tcaaagaaac ttaccccaaa 1680
ctgttccgta ccatgctggt gcccaaggcg gaagaactgg tggcaacgcc ctaccgcttt 1740
gagggcagta ccgaaaaagc aagggacttc tttgaggatg gtatgctgca cacctgccag 1800
caaatctatc agtatgcccg cgaggatgtg ccggtgacca tctactatgc ctataaacag 1860
agtgacacgg acgaaagaga agctgaaaaa cagaccgctt ccaccggctg ggaaaccatg 1920
ctcagcgcta tcatcaaggc aggctttgcc attactggca catggcccat gcgcaccgaa 1980
atggcaaacc gctccattgc gtccggcacc aatgcgcttg cgtcctccat tgtgctggtg 2040
tgccgcaagc gcccggcgga tgcccctcag gctacccgcc gcagcctgat tgcggaactg 2100
aagcgggaac tgcgtccggc tttgaagaaa ttgcaggaaa gcaacattgc gcctgtggac 2160
ttggcgcagt ctgccattgg ccccggcatg ggcgtgtact cccgctatgc ccgcgtgctg 2220
gaagcagacg gtacccccat gaccgtgcgc agtgcgctgc agatcatcaa tcaggagctg 2280
gatgtgtact ttaacgagca ggacggcgag ctggatgcca acagccgttt ttgtgtagat 2340
ctgtacactc agaacgcctt taacaacatc cgctttggcg atgcagatac gctggcacgc 2400
gccaaaaaca cctcggtggc agcactggcg gcaaaaggcg tgctgagcgc cgaaaagggc 2460
atcgtccgcc tgctcacccg cgaggaactg ccgcaaaaga ccgacccccg cgaagaaatg 2520
atctggctgc tctgccagca gctcacccac gccatggaga ccgacggcgt ggaagcctgt 2580
gcgcagatcg ttgccccgat actggggtcc aacgccgagc gtgccaaaga ccttgcctac 2640
cggctgtaca ccctcgccga gcgcaagggt tgggcgcagg agggctacgc ctacaatgcc 2700
ctcgtggtgg catggcggga aattcagtcc cgtgcggcag aactccagca ggcaacaccg 2760
gagcagacct cgttcttcta a 2781
<210> 111
<211> 1263
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1263)
<223> ICBIDGAJ_01554
<400> 111
atggaataca ctgtggatga agtttatggt ctttctagaa acattccgct aaattatgta 60
gaacgtcatg acgttgatga acgccttcgt tgcaacctaa atagagacaa acatatcact 120
atctttggaa gttcaaagca aggtaaaacc tgtttgcgaa agcattgcct aaatgagaac 180
gactatattt tggtgcagtg cagcaatcga tggtcattat cggatttgaa tgccaacatc 240
ttaaagcgtg ccggatatga gttaactgaa tccaccaatg taacctatga aggcaaagcc 300
aaggttagtg cgtctgttaa gattttagat gcaactcttg gtggcgaggc cggtggtgga 360
gcaacaaaaa atgtcacgca tcgtcagttg gaactggact tgtcagatgt aaatgatatt 420
attggtgctt tgaacgaagc ccgctttcat caatatattg tactcgaaga ttttcattat 480
cttaaaagcg aagtacaaaa agattttgcg attgaattaa aagccttcca tgagagttcc 540
gagctgtgtt ttataatcgt tggtgtttgg ttggatgaaa acaaactcgt tatttataac 600
ggcgatttaa ccggacgaat tgttcccgtt aatgccgatt tatggaatga agatgagctt 660
cgagaagtga ttcaaaaggg agaagacttt ttaaacattc gtttcaaaga gtcttttaca 720
agtgaagcca ttaaagcaag ttccggaaat gtttatatcg tccaagaaac ttgtcaccgt 780
gcctgtaatg agtctggaat tcacaaaacc gttgtgggtg aacggcggct tgttggtgat 840
ggactaaatg ccagaagtct cgttgctgaa attattcagg agcaatctgg aagatataat 900
gccttcatta caaattatgc aagtggtttt caggaaaccg cacttgctat gcacaaatgg 960
ttgctatacc ccattctaac atcaagcatt gaggaacttt ccaaaggtct tacttacaga 1020
agtattcgat caaagatcac gagtggacat ccacaaggca aaaatcttaa tccggggaat 1080
attacgcagg cattaaaagc agtttcttct ttacagcttt ctaagtcgat acaaccaatc 1140
attcttgact atgacgaatc gaatttaacc cttcatattg tagataaagg ttttttaatt 1200
tggttgtcca tgcaagaccg aaacgaactt ctctcaaccg tgggtctgcc tgaaatgact 1260
taa 1263
<210> 112
<211> 612
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(612)
<223> ICBIDGAJ_02163
<400> 112
atggctactg cgccaagcat gggaaaacta atctatcata tgacatctat agataatctt 60
ccttcgattt taaagtttgg tctgctctct cgaaaatgca tattacaaaa ccacgacata 120
cactttactg atattgccga tccagaaatc ttaagtaaac gtgagcgata taaggaagct 180
ctttcacaat atgtcttatt tcattttttt gcaaaaaatc catttgatgg tgcagtgtgc 240
gaaaagtatg gatcagaaaa tatggcaatc atcgctgttt ggagaagtat ttgtgaacat 300
aataattatc aaataattcc atcacatcca ttggatagtg atgctccaga tctttattct 360
tatggagaag gtttcaagaa ggttcgatgg aatatattag acgatagaga gcatcgcgat 420
tataaaaatg cagagatccg gaaagcatgt atggcagaat gtgttgtgaa gggatgtgtt 480
ccggtatcag attttgcata tatttatgtt tatagtgaaa gggcaaaaga aaagatttta 540
aaaatggaaa atgccgtagc tattaaggat aggatacagg ttatgcctag tatgtttccc 600
ataagtcgat aa 612
<210> 113
<211> 1020
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1020)
<223> ICBIDGAJ_02162
<400> 113
gtgtttttct atacaacagg agatttgctc cagtccgatg cggaagctct tgtcaacaca 60
gtaaactgtg aaggttatat gggaaaggga atcgcctatc aatttaaact taaatttcca 120
aacaacaaca aagactatgt taaggcgtgt aaaaatggta cactacgtcc cggaaaactt 180
catgtttata aggaaagtga aaaaatcatc attaatttcc cgaccaaaga taaatggcgt 240
gaaaaatcac gaatggaata tattgaggat gggttggatg cgcttgtttt actaataaaa 300
gaactcaaca taaagagtat agctattcca ccgttgggaa gtggtaatgg tggtcttatt 360
tggaatgacg ttaagcaagt tttggcaaaa aaactagagg acacagccaa acaggtagcg 420
atttatattt atgagccttc tcgaaacttt gccacaacgc caacacagga gccaaaactg 480
agcacatcag cactcgtgtt aatggaatta aaggggcatt taaaaaagtt taacagtctt 540
cgtttgcaaa aagcggcgta tttcatggat ttgttttcct caaaaaaata ttttcgtttt 600
gttcctcata aatacggtcc ttatgatcat tccattgata tagttagtaa gggaattcgt 660
gaatttcagc agtttcatgg aacatcttct acaaaagaag ctgagaaaat tctatttaat 720
aaacttacga gtgagtcggt aaataatact ttacaagcat tgctcccttg gatcataaag 780
tcttgtgatt ttgtaaactc tattgaaact gatcatgaac tagaatgttt ggcaacaatt 840
tgttttctaa ttgaaaattc aggaggctta acagcagaag gaattgtttc cggattcaag 900
aattggtctg aggaaaaggc aaagaggttt actgaacaag aaattatcga gggaatccaa 960
aagttatata tgcttggagt tatagaaaaa aatcttgtag gttataacct tgctgcataa 1020
<210> 114
<211> 222
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(222)
<223> ICBIDGAJ_00155
<400> 114
gtgacagcac agacaatgca aatcgggaac acaccttgcc gcatttacgg cgaagacgat 60
gcagaatacc tgctgctcca aatgacaggt gagcatgagc tgcaaagtat ggattatgaa 120
gtggcggcca ttgctcaaag cagccagaat tttctgtttg cggctatccc ggtggaaagc 180
tggaacgatg cactttctcc gtgggaagcc cctgccgtgt ga 222
<210> 115
<211> 780
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(780)
<223> ICBIDGAJ_00152
<400> 115
ttgggaggtt caagagcgac gggaacagca acagaaaatt ccgatattga tataggaatt 60
tattatgaaa aagggaaagt tgattttgaa gagttaaaca ttaccgccca acaattagac 120
gatgcccata gagaacattt gatttgcagg gagggtgaat ggggaaattg ggttaattgc 180
ggtggatggc ttgttgtaaa tagtttccat gtggacttta ttttaaggga tattgcacgg 240
gtgaaagagt gcatcacgca aacagataat ggaaatataa ccatgcatta tcagacaggg 300
catccccatg cctatctgaa tgtaatgtac cgtggcgaat tggcatcatg taaagtcctt 360
tattcgaaag ataatgattt ctctaaatta aaggaatatg ccgaatgtta tcctgacagc 420
ttgcagagtg cattgatagc tttcttctta tttgagacaa aattttcctg tgaccttgcc 480
aaaagctact cgcagaataa tgatatatac tatatagtcg gtcatttatt ccgttctata 540
tcagcattga atcaagtttt gttcgctatg aatcaaacat attgcttaaa tgagaaaaag 600
gcggttctac ggattgaacg attctctatt cgtcctaaag actactgtaa tcgaattaat 660
gagattctga cactgacacc tgataactgc ttaataaaaa aaatcaataa attagaacag 720
ctttgttatg aggttaagga actggcagat agagcccgaa atgcaaacag gaaagtttga 780
<210> 116
<211> 264
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(264)
<223> ICBIDGAJ_00153
<400> 116
atgaaatata tcaatgcaca cgcaattctc cctgatatgt tggtcgagga actgcaaaag 60
tatattcaag cgggatatat ctatattccc gctaaagacg atcagcataa atcttggggt 120
gaattgactg gctctcgaaa ggaaatcgac aaacgcaata aagtcattat agagaaatat 180
cggaatggtg tttcggttaa tgaacttgcc aacgaatatt gtctttcgat atatgccata 240
agaaaaataa tatatcagaa ctaa 264
<210> 117
<211> 1440
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1440)
<223> ICBIDGAJ_01307
<400> 117
atggcaaagt tccagaaccc cggagcgttc tttctcggaa ctctggttgc tcaggagcag 60
aagttcctga agccgctgat tgaaaacgcc cgcaagcagg ggtacacccg gttcgttgag 120
ccgtgcgccg gcgctttcgc catgtcgcac atcgcggcgc agtgtgggta caagcccagc 180
gagatcgagg ccagcgacgt ttcgatgttc acctccatca tgggatatgc catcacgggc 240
cagtcccttg aggagctgga aatcagagcg gacggcttca cgaatgagga actgcttgac 300
cctgcggttg cgctctatgc gcagttgtac ctgcggactg tgaagaacgc cgggaaggaa 360
tacttctacg gcatcatgcg cgatctggaa taccgcaagg aggagcatct ggcggaaatc 420
cgcgaacagc tcgacagggc caagcagtcc ttgcatggga tgagctaccg cccgctggat 480
atgtggaagc accttgaaac gtgctatgat gacccccact gccttgtggt tgccaatccg 540
cccacctatg ccgctggatt cgagaagtgg tatgacaccg gcgggcgcat gacgtggaaa 600
gaacctgagt acggcatctt tgacccaaag accgggctga acgatctgta cgacaagatg 660
aacgatgcca agtgccttct gatgtgctac gaggagaacg ccccgggcct cactgccggg 720
catcctgtct ttgctcggta tggtgtgcgt gacggcatca acgtgtacct gactaccaac 780
cgcccggatg aggcgaccat gcttgccgag ggtaaaatga ttacccgccc gaacgagggc 840
aagctggagc cgctggattg cagcatcctg ccgcgtgatt atgaaatcac ccgcaagagc 900
aagattcaga ttacccagat cgagcgcacc gctgcccagt attacagaaa gctctggacg 960
cacaactttg tcggttcgtc tgcgcctatc aacatggccg tcctcatcga cggaaaactg 1020
gcaggcgtgt tcgggctgga taagtcggca ctcacgatgg gtgccttcgg tacgcaggtt 1080
tccgatgctg tgttcctcat gtacggcatg accgttcccc ataagaccta ccggctgggg 1140
cggcttctga ccatgcttgc acagaacagg ccgctgatta tgaatatctg cacggatttg 1200
gagaaggaaa aggccaagtc cctcaagacg gtgcagatga ccaagtaccc agaggccaag 1260
gaaatgcggg ggctgatgga gttgaccaag aaagtcccag ataagaagat gggctaccgg 1320
ctcacatacg agtcgccctt gtacgataga aacgccaaac aggcattgaa tgaatggtta 1380
gggagggaag aacgatggca gaaacagcgc gagaaaacca agtcagcagc gcagccgtaa 1440
<210> 118
<211> 264
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(264)
<223> ICBIDGAJ_01304
<400> 118
atggaacgaa aatccgataa agttagacgt ctggttgcag acggcgactt caaaggggct 60
ttgcggattg caaaagactt caggctcggc atcacgaagg aacagtcctc cacgatgaca 120
agagcgtatg agtgcatggt ccacggaaga ttctacaagc agctcggcta tgatctcgat 180
gagaagatag ctgagggcgt gaagattctt gtgggcttgt acggaaggag cgaggcacat 240
gatttacacc agccggtaca gtaa 264
<210> 119
<211> 453
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(453)
<223> ICBIDGAJ_01305
<400> 119
atgatttaca ccagccggta cagtaacccg gaactcaaga ccgggaacta cacagtcgtt 60
gggataacac ggggggcgcc taagttcccc cttcggtata cgcttgcagg caacatcatg 120
gagatcgcgc cgccgggtta tctgttcaac gaatacaacc gggagcggtt cacgccgccc 180
tacttccagc acatggacag agtagggacg gcgcggattg ctcatattct ccagcattat 240
gaggacatgg gcaagcccgt ggtgctttgt tgctacgaag atgtccgaaa acccggagag 300
tggtgtcata gactggtgtt cgcagaatgg tggctccaga gaacaggaga aatgatcgag 360
gagttgcctg acccgtcacc aaacaagtgg gcgaaacagc ctgaaccgca gaaagcggtt 420
gagcctgatg cagtccagat gaaaatgtgg taa 453
<210> 120
<211> 228
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(228)
<223> ICBIDGAJ_01870
<400> 120
atgaaaggcc ccaagcgtta tccgccgcca gaaagccgcg cagctagcaa acatgttttg 60
gtctacccga attggatgtc tgcacagaga tatcacgaat atcaagaatc gcgtgcaagt 120
gcagcaagag cagcgcatga caaattaaat caggaagccg atcggcacaa tgcctttgtc 180
gaaaatgcta aaaagcacgg tattcccatt tccaaaaaga aaaagtga 228
<210> 121
<211> 300
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(300)
<223> ICBIDGAJ_01877
<400> 121
atggttgaaa ataacgtaaa agagaatctg cttgacgatg aggaggaaat ctatgtgaac 60
ctgaatgatc tggtgaacct cagagagtcg gcggaactca aggaagccgc agatgcattt 120
gaacgctact tggaggacta tgcgctggca acaggaatgc cgcagagcgt cttgtcggat 180
atctgccatc tgtctgtaca ggcagcacac aggggaatgg aattctgctt tatgaaaggg 240
tttgagctgg gcgctcgtgc aatgcgaagc gcactggaag aggagatgat ggaggggtga 300
<210> 122
<211> 333
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(333)
<223> ICBIDGAJ_01301
<400> 122
atggaagaaa ataaaaatcc ccttatgggc catgtcgtaa aggtccctgc acaggtgtcc 60
ggcatccctg acggagtgca gatgacggtg aacgcagccg tgaccacctt tgcggcggtc 120
gatggcaaac cggctggcat cgaaagcatg ggtacgggag aatgtaatat gcttgccagc 180
tatacgcggg gaacggtctc gttctctgtc cacggggaga agcccgttat ggtgagcgtc 240
cgtctggatg agttgatgag actcctgcag gctgctgctg tatgtcacca cgagcaggaa 300
gacaagaaga atgctgagga ggaaaaggca tga 333
<210> 123
<211> 477
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(477)
<223> ICBIDGAJ_01014
<400> 123
atgagagaaa acatcgtttt tgattatttg ctggcaaatg cctggggttt gccgctttgc 60
cgtgtgtccg tgtcagaaga tggcttcgtt caatgtcagg agaacagaga aaatacacaa 120
ggactgcaac tggaaaaggc agaagtggat aaaatcaaat caatcgtttc agaacatacg 180
aatatattgg attatgacag taaagaactt gagtcgccag atgtgtttga tggagttatg 240
aatttttttg attttgaggc atctgatgga cgaaaagtga acttgatggc ttttaatatt 300
ggcgaagtga aaacccctgg catgagcttt tcaaaaggtc tcctagagga aggagagctg 360
gacgaaatcg tcgttccggt aaaagcaatg gaggtagtaa agacattcga ggaaatcgct 420
gctacgctgg tggcgaatgg agtggatgcc aaatacttaa ggctgacata tgcctga 477
<210> 124
<211> 933
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(933)
<223> ICBIDGAJ_01308
<400> 124
atggcagaaa cagcgcgaga aaaccaagtc agcagcgcag ccgtaaagta tgaaacggtc 60
gccgacatgg gttccggtct ggtcattgcc aaagtaaagc tgaccgactt ccgcgagcag 120
gacatcaacg ctcgcattat gaagaccgag atgcagaagc agcttaccga caacatcaaa 180
aagcggggcc agcttgaaag cctcccgttc tgcgcactca tcgacggcaa aatcgagatt 240
atctccggcc accaccgcat ccgttctgca aaggacagcg gtgtgctgac ggagcttttt 300
gtcattctgg acaccaccgg cctgcggcgc tctcaggtgg ctgcaaagca gttggcgcac 360
aacgccatca gcggctttga tgaccagtcc accctgaagg aaattgccaa gatgatcgac 420
gatgttgatg atatgctgga aagctacatc ggcaaggaca tcatcggcga gcctatggcc 480
gagcttgaga agctgctgtc cccgaaggtg gagtttgact ggaagaacgt cacgttcacc 540
ttcctgccgc accagctccg cgatttggac cagcttgtga aggttctggg ttctctcagc 600
cccgacatgc tgggcgttgc cgatattgac cagcacgagg agttcatcga aaccatcacg 660
aaatatcagc agttcgccaa tgtcaagaac accggcgctg ccatccatgc gatgattaag 720
gccacggaat ccctgttcga ggacctgcac ttcgacgaga gtcaggagtg ggtgcagctc 780
ccgaacctgt ttggttcccc ggctatcccg aaggaagccg ccgacaccat cgcacaggct 840
cttgacaaga tggtcaagga gggcgagatc ggccccaaga acaagtggca ggcgctcgaa 900
tactgggctg cggattatct ggcagggaag tag 933
<210> 125
<211> 498
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(498)
<223> ICBIDGAJ_01309
<400> 125
atgcctacgc ctctaaagta caatccggcg taccacgatg actgggcatg gtcgcttgct 60
atcaagggcg caacagatca ggacattgct gatgccttcc atgtttcgcg taggaccatc 120
atccgctggc ggcagacata cccgtcgttc aatgaagctt gccagcacgg gaaggaagtc 180
gccgatgcaa aggtgaagcg gtcgctgtat gaacgtgccg taggcttcga gtatcaggaa 240
aaggaaagcg tcatcgacgt agacccccgg acgggcgaac agaagccggt gcgggtccga 300
acgctcacca agaaagccgt ccccgatacg atggcgcaga tgtactggct caacaaccga 360
tgccgggatg agttctccca gacccagaag gttacgcttg acggagctgt tcagacatcc 420
ccgttcgata acctgacgga tgatgaactc cgccgtctgg ctcaaatgga cgagggcctt 480
gatggcgacg cagaataa 498
<210> 126
<211> 861
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(861)
<223> ICBIDGAJ_01952
<400> 126
atgaatgaag aaacacagcc gcttttgatt gcaatagcaa ttataatagt tatttcaatc 60
gccatatatg taatttcaga atttgtttct tatgtggaac aaaagaataa agaaaagcta 120
ataagtatag tacagtcaac aagcgagcga tatcaaaata tcttggcatt gaactctaaa 180
tatgattttt atgaagttca gccatattat tatttttata aaagtttaaa cagtaaaact 240
caattagata gattcgacta cgatgaattc tttgaagaaa gaattcgaga ggataagctg 300
ctaattgaga ccttagttag tcaggttgag gaaaatcaaa aactttttag aagatacaat 360
gaggagatac atgactgggt agccccatta agaggagtag attttacaga tacgttaaaa 420
gtttcatttg aaaaatacca tgaatatgag gaagaatttg taagtgctga actcttgacc 480
ccgacaacaa caattgtatt tatatgtcaa gcaatatata ctagccccaa agggagaaat 540
tcatattcag gaaagaaggc ctacacagta gaggatttgc agattcataa gcagcatatt 600
gaggagttag aaaagcagaa agaaacaaaa gaatatcaac ggagaatgat gacgcaatcg 660
ttacgatatg acattatgaa aagagataat ttcagatgcg tattatgtgg acgtggagca 720
gaagatggcg tgaaattaca tgtagatcat attattccgg tatcaaaagg tggaaaaacc 780
gtgcgtagta atctgagaac actgtgcgag gattgcaata tcggaaaacg ggataaatat 840
gatgaggatg gaataaattg a 861
<210> 127
<211> 156
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(156)
<223> ICBIDGAJ_02293
<400> 127
atgaagatgc tccacgatga tgccatcaac ccgctgttcc gggcggtggc cgagtgtgtg 60
gaggaaagcg tcctgagcag cctgctccac gccgagaccg tcaccggcta ccatggccgg 120
acggtgcagt gcctttccga cctgttgaaa aaataa 156
<210> 128
<211> 1059
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1059)
<223> ICBIDGAJ_01854
<400> 128
atgaaaaaaa tctgttttgt aatggatagt ctttcttttg tgccgactgg tggcgcaaaa 60
atgatttttg aatatgcaaa ccgtctacaa aataggggat acagcgtaca gattttatac 120
ttgatgggca gttcatggaa aaaatatcat ctgccggaga aattgcgcca gtggatgctt 180
tccagaatga cttacttttc accctcgtgg tttccgcagg ataaaaaaat cgaaacacta 240
tcttattatc aagctgatct agatgaaaga gtgaaggaaa ccgatgtttt cattgcaaca 300
gaagttacaa ctgtagaatc tataaaagaa cgatttttcg aaaaaaagct ggcttacttt 360
attcaggact atgagaattg gcgggtctca gatgaatatt gtcagaatac atataagtac 420
gaaatgacta acattgtgat ttcacgatgg ctgaaagata ttgtagatca gtatagtaga 480
aaaccgtcaa ttctagttcg aaatccagtc gacattcatg tgtatcgtct gaacacacca 540
atcaaagaac gaaagctgca tacaattgga cttttgtacc atgagatgcc gcataaaggc 600
cttcagtatt cgatgaaagc agtctatcag ttaaaagaaa aatatctgga tttggaagtc 660
tacatgtttg gcgttccgaa acggccaaag gaatatccag agtggatcca ttatacccaa 720
aaagcgacac aaacgcaaac tgtggaaatc tataacaagg tttcagtatg gctttgtgca 780
acgatagatg aaggatatgg acttacaggt cttgaggcga tggcatgtgg agatgtgttg 840
gtatctacac ggtacacagg agttttggag tatgccaaag atgaaaaaaa tgcgttacta 900
agtccagtga aagatgtaga agaattggtt cataatgtag aacgtgtttt tgaagatcaa 960
aaattgagag agtcgctggt tttggaggcg caaaagtctg ttgtcaagtt ttcatgggaa 1020
aaagctgtgg cagattttga aaaggcatta gaaatatga 1059
<210> 129
<211> 2085
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2085)
<223> ICBIDGAJ_00143
<400> 129
atgcgagaaa agaatgcaag cgcattatgc tcacaagggg accgagtagg aattgtattg 60
gctaaagaca gacgaccaat caatattaaa ggtggagcga aagcaaaaca agcagttaaa 120
gcgttatcca aatttggcct gatcagcttt tctaaagaac aaacatttaa gagttcgctg 180
tattctgttc attttatcaa accaatagca aacttaaagc aattgtataa tttgggcgat 240
gaggttttaa ttttatgttg taacgatagt ttgcagaact ttaaaagtcg aacaaaggac 300
ttgattgata tacttttggg ctcacagtcg gaatatagaa acaggttaga taagataact 360
tgttttcttg tagatgattg tgaagatatt gaggatgtaa tcaagcgaga cagaatagat 420
aacccggact ctaggttgat tattccattt tcatataagg aattggaaag tggaataaaa 480
gagaatgatc ttcaaaaccg gatgagaaca tttctttatg aacgtgatct ttttggtgtt 540
gcttctccgt tgcgtgatga caatcttttc ttcggaaaaa cccgatttaa tgtaatttct 600
gaattgtacg gaaaatatct ccaaggagaa cacggtggtg tgtttgggct ccgccgcatt 660
ggaaaaacgt ccattctttt attacttaga aggcgtgttg aacaaaatgg cggagtagct 720
atttattttg actgtacaaa atatcatcat ttgacgtgga atgatttttt aaatcagatt 780
attcaagaac tcagaaaaaa atataccgag ggtggggagg aaacagcgat tggcttcatt 840
tctaatgatg tagaatataa taaagatatc tcaagataca cagagaagca ggcatcaatt 900
agttttgaag aagatttgat tcaattgcat cgactgcttc acaataagcg tattctactt 960
atttttgatg aagttgagca aataagcttt ggaacatcat catcattaaa ttggagagat 1020
ggaacagacg ctttgttctt ttggcaaaca ttaagatcaa tctcacaaac agataataac 1080
attttttctt ttgtaatcac tggagtaaac ccgaagtgta tagaagatgc taaaatttgc 1140
aatcaaccaa atcctatatt taatggactc gctccacaat atattacttt gtttgattat 1200
gatgacgtga aaaacatggt gtctgaaatc ggtggtcatt tgggtttgaa gtttgaagaa 1260
gaaatatttg ccaaattagt cgatgactat ggaggacacc catttctgat acgccaagta 1320
tgcagtaaaa tgaatgaaga agttcttgaa aataaagaga ctagaccgtt taaaatttct 1380
aagtacagtt atgaaaagca gtccgataat tatcaaaata aaatgaaggc ggcaatagag 1440
caaatattag gtgttttagt agattattat ccaagagaat atgacctgct aaaagttcta 1500
gcattggatg gaagtgataa atttaaaagc gaacttcagt ttgctgattg ctctattgat 1560
catttacttg gatattgctt aatcaagaaa gaaaaagacg attactacat tcgaattaaa 1620
gcaattgaaa agcatcttca gcaaaaatat aaatttgata agacctattc ggatatttct 1680
gagatttact caatggtagc aacaagaaga tgtgcaatcg agaataaatt gagatctctg 1740
attggaatgc agtatgcgtt gcactatgga aagagtgcaa aaagaacttt gatggatgcg 1800
attgaaaaaa caacgaaaga cgatacacaa aaagccaagc tcgaatgtgc cgatttaaaa 1860
ggcgcaatgc aggaactgta ttttttacaa ctgaaaatcc taatagaaaa agattgggca 1920
tggtacgaac gcttattttc ggataaaaca aaatttggat atttttctga tgtcataaat 1980
aagaaccgag ttgatgcaca tgcaaaaaag ccgtcagatg aagatttatt tttgttgaat 2040
ttagcgttca agtactttga ggaagcatta gaagccattt cgtaa 2085
<210> 130
<211> 885
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(885)
<223> ICBIDGAJ_01314
<400> 130
atggcataca atgaggaaaa gctggcccgc ctgaagcacc tgaagcagct cgcacagaaa 60
gctaaggccg agagcgacgc tgttgctact cgtgttaagg ctctggaaga tgctggcgca 120
caggccaacg tgctggagac cattaaggtc aacggcgtgg tgcagaacat cgaggataag 180
gctgtggaca tcaaggttcc cggctacact gtggagaagt ctgagaagtc cggcgactat 240
gctgctgtct accagctcat gaaggatggc gttgccgttg gcgcggctat caacattccg 300
aaggatatgg tggttaagtc tggctctgtt gtgaccaacc ccaccggcca gcccaaaggc 360
acttatatca agctggttct ggcaaatgcc accaacgaca ccctgtatat tgatgtcggc 420
ggcctgatcg agtacgttac ctccggctct gctgcgggtg atatggttgt catcgccatt 480
gatgagcaga ctcataaggt caccgcatct atcaccgacg gcgcaatcac taaggcaaag 540
ctggagaccg aggtgcagac cgccctgaac aaggcccatg agcacgccaa caaggcactg 600
ctggacacct acgaccagac caacgccaac atcaaggatg ccgtcagcaa gaagcactct 660
cacgccaatg cggccgagat ggacaagatc gctaccggcg ataaggaaaa gtgggacgcc 720
acctccacca aggttgaagg tattgctgag ggcgctacca aggtcgaggc cagcaccacc 780
gaaggcaata ttaagatcaa tggcgtggag accgcggtcg ttaccatcgc caccgacgct 840
gaggtcactg agatgctggc cgaggtcttt ggcgcaaccg cctga 885
<210> 131
<211> 552
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(552)
<223> ICBIDGAJ_01311
<400> 131
atgctgatta ttttctcggt caatgaccag aaaatcaccc atgacctgaa aggccagctc 60
gtcgcaggca gcgtagacat tgtgcaggcc gcgttcaaat ttgacagctc gtgggatgaa 120
ctggacaaga tcgtcgtctt cacgagcagc gcttgtccca agcccgtccc ggtgcagttt 180
gccgatgagg cgttctacat cccgaaagat gtgctgaagc ccggcaagct ctacgtttcc 240
gtggtcggtt tcgggctgga cggccagaag aaaactacgc agaagtggga catcatgcag 300
gctatcaccg ttcagaagtg cggcgatggc ggcgattgtg acctgctgcg atatttggca 360
caaggtcagg tcgccgacgg gaaagtcgca aaggacgaag aagtcgaaga tatgctggac 420
actgtgttcg gcaaaccgga agctcccaaa ccagaccccg gtggctcgga ctccaatgac 480
aagaacgtca gcgaggacga tattgccacc gataaggacg tagccgatat gctcaacaaa 540
gtatttggct ga 552
<210> 132
<211> 1419
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1419)
<223> ICBIDGAJ_01310
<400> 132
atggcgacgc agaataatgt ttcgcctgcc aagcgcaagt acctcggctc caatgcccgg 60
attgcgctgg cgaaacggca ctacgccgat tatgtccagt acgtccacat gggcaggtgg 120
aaaagagcca gacaccttga cctcgtgtgt gagaagctgg aaagcatcat ggagggaaag 180
accaagcggc tgatgatatt catgccgccg cgccacggca agtccatgac cgtgaccgaa 240
accttcccct cgttctattt gggcaagaac cctgaaaagc gggtcatcga gatcagctac 300
agcggcgacc ttgctcaaca atttggcaag cggaaccgcg ataaggtcga ggagttcggt 360
cctgcgctgt ttgggcatac catctcccaa gtgcaggcca ccaaaacgaa ctggaacctc 420
gacaacggca tgggcggcat gatctccgtt ggtatcggcg gctccatcac cggctatggc 480
gcagacctgc ttatcgtcga tgaccccatc aagaaccgcg ccgaggctga atctgccacc 540
taccgcgata agctgtggga cgagtaccag tctacggtga gtacccgact gcacgcaggc 600
ggcgctgtta tcatcatcct tacccgctgg cacgaagatg accttgccgc ccggctcctg 660
aacccggagt acggcaaggt tgaggactgg gacattatct cgctcccggc cgtttgcgaa 720
gacccggcta ccgaccctct gggccgtgag ctaggcgagg cgctgtggcc tgcgggcggc 780
tatgacgaag catgggctgc acaacagaaa gagactgtcg gtacatacgc atggtcttct 840
ctgtatatgc agacccccac accaagctcc ggcggtatgt tcaagagaga gtggtggaaa 900
cgctgggcgg cgctgccgtc cggcctgcat gacttcatcc agtcgtggga ctgcaccttc 960
aaggacaagg acggttcaga cttcgttgtt ggacaggtct gggcaaggaa aggtgcagac 1020
cgctatctgc tcgatcaggt gcgtggccgc atgagcttca cggaaacgct ggatgccatg 1080
cgcgggcttt cctccaagtg gccccagacc accagaaagc tggttgagga caaggccaac 1140
ggcacggcgg tcatcgacgt tctgaagaaa gaaatccccg gaatcatccc ggtggagccg 1200
tttggcggca aggtggtccg cgcccatgcg accaccgctg tggctgaagc tgggaacgtc 1260
tacatcccag cggcatctgc ctgcccgtgg gtgatggact ttgtggaaga aatggccgcg 1320
ttcccaagcg gtgcgcacga tgaccaagtt gactgctatt cgcaggcgaa cgcctactac 1380
aacgacaaca cgtttgatat tcgttcgctg ataacgtaa 1419
<210> 133
<211> 315
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(315)
<223> ICBIDGAJ_01313
<400> 133
atggctgtga acaataccgc aaagacctac tccaacatgg agttccccct gagcatgaag 60
cgtcaggatg ctttttctct tgaccccacc tgcgtgtggc cgtctatggc tgacgcgcag 120
aactatgcga agacgaaccc gactgcctac atcggtcagg tcctctccgt ggtcgtggac 180
ggggttgcca cctcgtacac catccagaat gccgccggtg atctcgcccc gctgggcgct 240
gcggcggttg acatcgcaac cgattctgag gtgagcgaaa tgctgagtga agtattttcc 300
accgataacg cctga 315
<210> 134
<211> 1590
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1590)
<223> ICBIDGAJ_01312
<400> 134
atgcccgtat ccgcaagcaa acttgtaacc ctcgctcagt tacaggtgca ggcggagaga 60
gtcaagcagg agctggcgaa gtacacgctg gcatccgaac ttggttccct cgccaaaaag 120
agcgaaatct cggaagctga cctctcggct gctctgaagt ccgttattga cggaaagatg 180
gatgcagcag acagtatgac gaccgaggca atcaacagtg ccatcgccac cgccattgca 240
aagtctgctc atgcacgctt cgagaaagtt gagaaggttc cttccaacga tgaggcgcag 300
gataatgtgc tgtatctggt gatgaatgct gccaccgggt actacgacat ttacgctaag 360
gtcggtgagg aagtcgtccg tctggatgat accaccgttg acctgagcaa ctacgcgacc 420
atcgaacagc tgaatgccgt ttctggcggc attggcggca cggtgtatgc aggcacgaag 480
gaagacctgt ctgcatccga tgattcggtt atcgccgcgt atttcaaggc gcacaccgac 540
gtggccgtca agaagggcga tgtcttcgtg gtcacgacca ccgttggcaa ctctacctac 600
gagaagtccg cctacttcta cgacggcaag gcgtgggtgg cgatgaccgg caatgtcgat 660
gccgataagg tcatcctgcg cgagaacatc acgctggccg gtggctatac gcaggtcggc 720
aacctgacca agagccagaa cggcacggcc actttctcct ccaaaggcaa gagcgtcatg 780
gatgccctga ccgagatttt cagcaagcgg ctccagccca gcatcaccgc ccagccgtcc 840
atcggcacgt tcacgctgac cggtgctggt gctgttgagg ccggcactaa ggtggcttct 900
gcggcctact ctgctgcatc cctgaatgca ggctcctatc agtacggccc ggccaccggc 960
gttaccgcta ccaactggaa ggtcgatcgc attaccaatg cggccactgc gcaggtcgtg 1020
tctgtggccg ctgcatccct gaccgctggc tctgataaca acggcggcgc gggcttcatc 1080
atcggcgatg caggcggcga taatgccgtg tccagcctga agtaccgcgt caccgccacc 1140
cacggcgcag gtgtgaccgc aaaggacaac ctcggcgcgg catccagccc tgtcgtagcc 1200
attgcggccg gcactaagac caaggacacc ggagcctaca ccccgttccg taatgtgttt 1260
tatggcacgt ctaccggcaa gcctgctctg gacagtgcgg ccatccgcgc actgggtaaa 1320
accggcaagg catacgccgc cggtacgctg accctgaatg ttcctgccgg tacgcagcgt 1380
gtcgtcatcg cctgcattgc taccgcaaag ggtgtcacca aggtcatcaa tgaaaccgcc 1440
atgaacgcag atgtcaccag cacctttgtg aaggccaccg tccctgttga gggcgcaaat 1500
ggctataccg cgaaggacta taacgtctgg gtctttgagc ctgccgttgc ttatggcaac 1560
gccgcagtcc tcaaggtaac gctgggctaa 1590
<210> 135
<211> 738
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(738)
<223> ICBIDGAJ_01319
<400> 135
atgaacaaag ttacgatttt caagtacgag gaaaacaagc tggtgcgcac catgagcatc 60
aacgacgaac cgtggttcgt cctgaaggat gtgtgcgatg tgctgggcct cagcaacagc 120
cgcatggttt ctgaccgctt ggatgacgat gaaaaggggg tcagtcagat ttacaccctt 180
ggcggttcgc agatgatgag cattatcagc gagtccggcc tgtataacgt cattctgcgc 240
agcgataagc cggaggccaa acccttccgc aagtgggtca cggccgtggt gctgcccagc 300
atccgcaaga acggcggcta catcgccggg caggaggagc tttccccgca ggagcttatg 360
gcaaaggcgc tgctggtcgc ccagaagact ctgaccgacc gcgatgcccg catcaaggag 420
ctgacggcgc agaaccagat catgcagccg aaggccgagt attttgacga gctggtggcc 480
cggaacctgc tgaccaactt ccgcgaaact gccaaggagc tgggcatcaa ggagaaggat 540
ttcatcggct ggctgctcga ccacaagtat gtctaccgcg accagaagaa caagctgatg 600
ccgtatgcgg caaagaacaa cggcctgttc gaggtgaaag agggcaaggg ccggcacaac 660
gactgggctg ggacccagac gctcatcacc ccgaagggtc gggaaacctt ccgcctgctg 720
tgcaaggaac tggcatga 738
<210> 136
<211> 498
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(498)
<223> ICBIDGAJ_02609
<400> 136
atggctaaac ccaaagttac aatgccggat gacctgaaga gcaaatgcgc cgctgtcatt 60
cacactgcca caacagctgc cgccgctgcg ggtgttatcc cgattcctat ggctgataca 120
attcccatca ccggtgctca aatgaccatg atcatgggtc ttgccaaagt gttcgatatc 180
cccatgacac aggctgccgc tcaatccatt cttggtggta cgatggccag tcaggcgggt 240
cgtgcaattt tctccaacat cattaaggga atccccggtg tcggaaccgt tgtgggcggt 300
gtcatcagcg ctggtacttc tgttgcattg accgagaccc ttggctggat cgttgcggag 360
gacttttata aacaaagtat cggtctcggc tcagacagcc ctttggaggg cgcaaaagat 420
gcctataccg gtttcagtga ctttgccaaa tctgtaaata ccagccagtc aaagaaaaaa 480
catttcggtg gtttttaa 498
<210> 137
<211> 633
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(633)
<223> ICBIDGAJ_00289
<400> 137
atgggattca cccaccggaa gcactgctct tttattgctc cgctttgctc cacaaacgcg 60
aacttgtcgg ggcgaggccc ctccatctgc tcccgcagac cgttcggtca cttaaaagcc 120
ccactgggct ttcattgctt cgcaaacgcg aatttcactt acttagataa tggcaatgtc 180
aattttcctg ataataaaaa atacagcaga agtaaaccaa ctataattag aataccgcca 240
accactttaa tgccaattcg attaaccttg ttatttttta taattttatt tgcaaaaacc 300
aatagtagcg caccaactac tataataaaa acagatatta acggatacat gagttttctc 360
ctttcaaatt ccgatttatt gaaccaagcc gagtatacca cactcttccc acagatacaa 420
ccacgcaaaa aactcccatg ctcacatcgg aagatgctgt gcacgggagt ttttgctgcg 480
cctgttacgg cgtattgtta cttattgaag gtttcctcgt tcagcaggcc ctcgctcttg 540
gcaacgcaga tgctggcaac tgcatcaccc accacgttca gggaggtgac cagcatctcg 600
atggggcggt tgatggccag gatcagggag tag 633
<210> 138
<211> 162
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(162)
<223> ICBIDGAJ_01320
<400> 138
atgatggagg gagcaaccat gacattatcc cagattccga cgaaagacct tgtggatgaa 60
ctgcggtgca gggagggcgt agacaccacg gtggctgcgc cttatgagga tgccgcagtt 120
caggtcaatg gcccggcaat catattggtc gtaaccgact ga 162
<210> 139
<211> 489
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(489)
<223> ICBIDGAJ_02459
<400> 139
atggctgaaa attttagtat tgagcattcc agaacgaaaa tcactgaggt aaagaaaact 60
attgaagata aaaaacaaaa gctggacgag ttaaagcaac aaaaaaagag tcttatggat 120
gccgggcttg cgttggattc ttcaaattta gattcagctg ttcaagctac ccttatggaa 180
agcattaacg attctctgcg tgatgttgag aacaaagctt atgacgtttc gaaggatgca 240
aatcagaatc tacagagcct tgaacaaatc cggcaaaatg ttgacgatga aatcacagat 300
agtcaaaagg cgaagaagaa actcgaccaa accaagaagc tgttagacac attaggtgtt 360
ggaaaatcat tggagaaagg agtaaacaag ctggatgacc acttacagga agcaaccggc 420
ttaaaaggtg aagtcatttc agctatgcag gatttggaaa aagtctaccg tcagttagat 480
caaatttaa 489
<210> 140
<211> 336
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(336)
<223> ICBIDGAJ_01733
<400> 140
atgagctgga cgctggaata ccttcccgag gccgaaaaag atctgaaagc actggatggt 60
agccaacggc tccttgtcct gaaagccatc aaaaaagtgc agcaaaatcc cctgcctgct 120
gaagaaaatg gttatggaaa aactttgggc aaccatagaa gcaccaatct ggctggattt 180
ctaaaaatca aacttcgtgc ttccggcttg cgggtcgtct atcagctgcg ccgcaccgag 240
acggaaatgc tggtaatcgt catcggtgtc cgtgctgacg aggaagtgta tgaaattgct 300
cagaaacgat ccaatcaata taatctgctc ggctga 336
<210> 141
<211> 624
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(624)
<223> ICBIDGAJ_02227
<400> 141
atgggtgggt atcaagtgaa accagaactt cttgaagcgg taaaaaaaga agttacagct 60
acgaacctgc aacttctaaa atctttgcag ggaaaagaag atatttttaa cacaacagca 120
tatataaaaa tacttttttc agatacgctt ctcgaagatg ttgacttttt aaacacttta 180
agtggacaac caatatttaa ggtgcggtat gctcaaatga tcctgcggga tatgcttgag 240
caagtaatag agttcatatt tcttatgaag catccagata tgattcctga atatctaggc 300
gataatatca attctaatgc accgtttggc tctaatccgg taaatgaatt acaaaagatg 360
gcaagtggac gatatgcaga tggtagaaaa acagtatctg aaatggcgaa ggacatcaac 420
gaaaagaaat cttctcccgg acggcctgcg ttatatgaga tatatcgatt gttatcagaa 480
gaatgtcata attcatattt ctttgcaagg ctggatgatt ttaaagaggc aagagatcat 540
agcgaaattc ttgcactgtc agaagatcaa gctcagcatc ttgtgataat tgtgatgcgt 600
tttatggaag cgtacagagc ataa 624
<210> 142
<211> 1305
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1305)
<223> ICBIDGAJ_01539
<400> 142
atgcaggata aacgcttcta tccgtatctg tttcttcatg cgggtattgt gactttatgg 60
gttatattgg atagaacaca taaaggaatt gcgaatgacg gagccatcaa cttattgtcg 120
attgccgtct tgctttgtta tttcaatctg ctctatcttc atgtaatgac atcacggcga 180
aaggcaacaa tatctgaatg tggctggaac ctgctttctg tttcctttat tgcggcgctg 240
atgtatgatg gattttccac cttatacatg ggtgcatttc tgttttttgc attgattatc 300
ggaataatgc tggtaagaac tgacgcaagc cggggtaaaa tggttcgctt gctgtttgga 360
attgcagcta tcatactgtc gttttttgat ttccaaattc tccctgctat aaccatgtta 420
gttggaatgt tcatgggaat tttccttgat tatagatata taaatttgaa acaggttaat 480
attcttccga ttgcccagag gaaagcaaga tatgtcctcg ctcttatgat tcccttgttt 540
acagtcgtac tttattgctt tgatttgtcc accctacaag tcaatgtatt ttttcagctt 600
ataatgcttt tatttgaggc ttttgctgtc attcatcttg gcgatatgga ggcccgttac 660
aaggagttga caaagtatta tgaattaacg aactatattg caaatgagag ggaagatttc 720
tcaagactgc ttcataacga tgtgcttcaa gacattggag gtgccaaaaa tctcctgtcg 780
cttcgctcac cagatgttga tgaaacaaaa aggatattgt ctgatttgga attgcgggta 840
agaaatatga tgaatttcta ttcctctaat atcttttcgg ggtatgcttc atgggaacat 900
atcggatata tgcttgacgc gattaagaag ctgtacccaa agaagaatat acttgtagat 960
ttcacgattg acagcgaagc aaggattgct ttgaaaaaag ataacagttt ggaacagact 1020
atgcagataa tcaaagaact tgtcaacaat gtttataaac acgctgccgc tacttttatt 1080
catttggaaa tcgcgctaaa tgaagaaagt agattcgtaa ttacctgtca aaatgatgga 1140
gcgaaaccaa atgacattga aaatattctt tcttccaaag gtggtatgct gttcttgacg 1200
gtgttgataa atgggaatgg tggtaacatt cagtatttag agaaagatgg tattttaact 1260
gcaacggcag ttttggggag aaaaaatgaa gatattacta tttga 1305
<210> 143
<211> 279
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(279)
<223> ICBIDGAJ_01858
<400> 143
atgaaaattg caatcttgat tcaatgtcat aaaaatccaa aacaaatcaa tttattgctt 60
gaacgtttaa atcatccgga tattgattgc tatcttcata ttgataaaaa ggctgacttt 120
acagataaaa ttattcatag ggaaaatgtg tttgtgcttc cggatgaaca gcgtgtttcg 180
gtggaatggg cacagatttc gcaggttacg gcaacgctaa atcttttgaa tacagctgtt 240
gctggtataa gggggggggc tatgactact attggttga 279
<210> 144
<211> 648
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(648)
<223> ICBIDGAJ_02222
<400> 144
atgactgctg aaggaaagat taagcaatgc tcaatcgtgc ttacacgcga ctgtaatttg 60
cgttgcactt tttgctatgt aaaaagtgct ggatatgtag cagataatcg aatcgaatac 120
gatgatctta aaagtatcgt taatttttgc tgtgaagcaa aagtcaagta tatattcttt 180
accggaggag aacctcttac atacccacat cttccggaaa ttttgcagta tatcaaaaca 240
agacgtcatc ccataacaac tgcagttgca acaaatggtg tcttgcttag caacatggaa 300
ttatgccgga tgctgattga tagtggcctc ggatatgttg atgtatctat gaaaggaaga 360
aatcggaagg aatggtgtga aatgacggga tatgatggca ctgagaaaca gcatcaggca 420
attcgtaatc tggcttcgtt gccaatagag tttacttgtt ccatggtgat aacccccgag 480
aatgttcact ccttttgcga agctgtccaa atcgctcatg ataatggtgc aaagcagttc 540
tcgttcacat tcatcatcga caacaataat gccggggaca aagatctgat ttacctgcaa 600
aagcacgacc ccataaaatt agtccgtgat ttcatttctc aaagataa 648
<210> 145
<211> 1197
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1197)
<223> ICBIDGAJ_00136
<400> 145
atgtctgatc atcaggcatc tgagcaaatg gtgggctatc tttatcaggt gcgatatgcc 60
ttggcgttgt tgttggatga tgataactcc gattcccaaa taagcataga aaagtttgat 120
gatgtcgcat ttgttgacgg gaatacgcct atagaacgta tacagttaaa gcatcatgta 180
agaaaagctg gaaatcttac agataagagc actgatttat ggagaacgct aaaggtatgg 240
ctcgatgtgg tatccaaatc accggatata atcgaaggaa cggaatttct tattatcaca 300
acagcatccg ctcccaataa cactgtcgcc ttttcgttaa gaaaagaaaa taggtcacaa 360
agagatgcgg atatgataga tgcactgtat gaaaaactaa aaggtgtatg tacagattca 420
gaaagccaag gcaaccaaaa attttatgaa gcatttttgg cagcagatga aaaacttgcc 480
aaaggtttga taaacaaaat ttatattctt gataatgcaa gcaatatagt cgatgtagaa 540
aaaagtatac gaaagcaagt tcggtatagt tgtgatcgca aatatgaaga caaagttatg 600
gaacgcttgg agggttggtg gtatagaaaa gctatcgaag gactttgctc agatacacca 660
atatttatat tacaagatca agtcagatct tatattgtat ctacagggca ggagtatgct 720
gctgataatt tgccaataga tatttttgat ttaggcgatg accagacaaa cgaattgagt 780
gctatcgaca aaacatttta ccagcagcta aaattgattt gtcttggaaa ccatcaccta 840
aaagttgcag tgaatgacta ttatcgtgca tttaatcaac gtgcaagttg ggtacgaaat 900
aatttgctat acattgatga attggataaa tacgagcgac ggctaattga tgaatgggaa 960
cgtgagtttg cgatgatggc agatgcactt gaggaaaatc cgaatcttgc agaagatgaa 1020
aaagtaaaag caggaaaaca gcttcttact aaaatggaag agaaagatat tcggattcga 1080
gaaaagtgtc aagcaccctt cgttatgcga ggaagttatc atatattagc tgaccaacgg 1140
aaagtgggtt ggcatatcga ctttgaagaa cgtctgaaac agttgttggg catataa 1197
<210> 146
<211> 489
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(489)
<223> ICBIDGAJ_00137
<400> 146
atgcaagagt ggaaaatgcg aacaagggaa atcgcatatc ttctcaatcc agccttttgc 60
ggaagaatac tatataccac gattcgggcg tacaacgaaa agtcgcatcg ggcatttcca 120
tttccgctgg tttatttggt tttacccttg gtcttacata aagaaacgag agctataata 180
tccagtagaa cacatctgca tatatgggct caacaaaatc cgcagctttt gatagacttt 240
cctcgaagag cgagtgagtt gattcctatt acaaatgaag cggttgaaat gctacttcag 300
acaagaaaaa ttattttgac accatctggc gaactggaag ttcctccaag gtcgaaaatt 360
ctgaatagag aaaagtatac cgattctgaa attgcggaat gccttacgaa atgtgcacat 420
atcgcaaggt ggtttgaaga tgctgggaaa gtcgaaaaca tttacatcag tttgggggta 480
agaccatga 489
<210> 147
<211> 444
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(444)
<223> ICBIDGAJ_02610
<400> 147
atgtcctttt tcaagtcaat cttcaatgcc gtctgcgatg ccggttctga actgctggat 60
aagcagcagg attatgcaga gggctttgaa gggatgagtg attatcagtt aaagcagctc 120
taccgagaga tgagagcaca tccatataac gtcggcattc tgaatggaat tgcgcgaaat 180
tcagctttag agcaggaatg cgtcgcacgg ggtatcgtta tctcgaatca ggaagccgaa 240
cgccagcggc agtattggca aggccgctac tcaaaaatga gtagtcatgc actcaagcga 300
gaacatcaat ccatcatctg taaatacaga agttatgcat ccggcccagc aagagatgac 360
gattcccttt tgaaagcctc tattctgaag cctcaaataa ccgctctcga aaatatcttc 420
cgtgaaagag gactatcaac ctaa 444
<210> 148
<211> 1158
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1158)
<223> ICBIDGAJ_00130
<400> 148
atgagagtca acaaaggttt gatgatagca gcaacatttg atccgaccaa aagaacctcc 60
ttgataactg tagcagatat gtgtcgtaaa attgaggaga actcgatttc tttgccgttg 120
tatcagcgag atatcagttg gacacttcag aagtgtatcg atcttcttaa ttatcaattg 180
tggggaaagg ctccggtttc tcctatttct atcaatgtta taaatactgt ggatagtgct 240
gttccgcaag tttcctttat agatagagaa atcatctcaa ctattgaacg cggtcagtac 300
tcggtcgtgg atggccagca gcgtttaacc actaactata aagcatattg taatcatgat 360
gattttcgaa atatcgtgtt agacttagga aaaggcgagt tcacagaggt gcgtgactct 420
atcaggagta atcaaattcc tgttggtatc ctcttaaata aagaggatac caaattattt 480
gagtatacta aggctaaaag cgcacttggt tctgccgatg tcttgtctgt gctccttcaa 540
gtacgcagca aaatgagaaa ctataattat actcttaatt cggctgaaga cctaactgag 600
gatgaacaaa ttgagtggtt cgaagttcta aacaatgctg gcagccgagt aagtattatt 660
caaatgcgct tttctaaact gaaagctcat ggaattgata tttataaaca gtacacaaac 720
ctctaccgta cccgtgtata tgaagcagga tacgaagatt ttttcactcc gcaaaaaacc 780
aatgtttctt acccagttgc agcattaaat cctgcgtatg aagttatcac tcagaagcct 840
cattccggaa attatgctcc tattccttct gatactaagg aaaatcaact ttgtaacctt 900
tctccagaac agcttacaca atgcttttct atgactttag ctgcactcga tcgcacttta 960
gacttcatca atgagaacac acccactcaa cttcctcgca ttgattatat taattattta 1020
ttaggatatt ttatcttcca taacgaagtt ttgaccgaaa ataacaagga aaaacttctt 1080
cagtggatgg ataatgttga tttcaccaac aagtccaatt ctgaacgacg tgatattttc 1140
accgcattga tcacctaa 1158
<210> 149
<211> 117
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(117)
<223> ICBIDGAJ_00526
<400> 149
atgaaggtgg ttctggacga ggatgaattt tcagggccaa cggcccgggc cgcatcggca 60
ctggccgacg cgctggccga agaggacgac ccttaccgtg aattgaacaa ctcgtga 117
<210> 150
<211> 426
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(426)
<223> ICBIDGAJ_01328
<400> 150
atggggctgg gcatttttcg cagagcattt gttgtgcgtc gcttcggcga ggagaacatt 60
gtcgatggtt atggggtttc cgggtataaa gacttcatca cgtccctgaa tgttcagccg 120
ctctccaaag atgagcttca ggcgctcccg gaaggtgaga acaccgtaaa gcgcatgaag 180
gctttcggtg atctcgtttt ccataccgca gaccgctctg tcggccgcag agccgactgg 240
cttttctatc aggggcggat ggacccggaa ggacactggt atgaatgtgt cagctcgctg 300
gggtgggacc acacgatggt gggtcactgc cgcagcgagt ttgttcaggt ttcagcagca 360
gaggccaacc gtatgccgcg ccctgaaatc cgagcagatg ggaaaggtgg gtattgctgc 420
gtatga 426
<210> 151
<211> 681
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(681)
<223> ICBIDGAJ_01329
<400> 151
atgacgcttt ctgaactgaa gaagctgctt gtgcagctca cccaaacgta ctttgctgga 60
gcaaccgtga cgtatgccaa gcagagcttt gtagcaaagc ccggcagtcc gctggtcacg 120
ctgaccaccg gctccgtcaa ccggtcgaga aacccgccgg tcaaaatcat tgaaggcaca 180
ccggtagcct tttatcctgc atctgttcct gtgcagattg atctgttcac gcatggcagg 240
caggaagaag tggcaccggg cttcaccccc attgccgaaa acacggctga agatgatatg 300
ctggcctttg agagcttcct gaactccccg ttcgtaacgc agtggtgtca ccagcatgac 360
atcgccatcg tcgttcctac ggcagttcag gatttgaccg atttggtgca tgataccaac 420
tacgagttcc gggcaatgct ggaaatcgcg gtttatttca ccatgacggc catcggcatt 480
accggaacgc tggacatcga cagcgtgaag cattccgatg gcgaagatga catccaagct 540
gatgatgtca tcaacattga gccgcaggta accccgacac ccagcggcgg cggcagttcg 600
gagatgactg cccatgaggg cgaatatttc acgaatgccg agataaataa tcgacccgta 660
aaggaggaaa aagatatatg a 681
<210> 152
<211> 309
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(309)
<223> ICBIDGAJ_00444
<400> 152
atgaagtccg caacgaagca tattgttatc agcaccattt tgtgtgcatt gacgctggta 60
gtctttctcg ctttctataa ccgcctgccg gcgtctatcc ccgtccactt tgattctacc 120
ggagttgcaa attctttctg gccccgcaat gttgtagtgt tcggcgtccc tgtggcttgc 180
gtcctgctga acctcatttc tggctttacc gtaaggcaga aagagaatgc aaagccgtat 240
atgtactata tcatggctgt tgttgcattc gtagcaacgg gcatcatgat ttatttgggg 300
atgaagtga 309
<210> 153
<211> 597
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(597)
<223> ICBIDGAJ_00445
<400> 153
atgaacccca aaaataaacg aaccttgttt ctgacaagta caatttgcat tattttgtcc 60
atcgtagcat tcgctctgtc ccacatgggc gaggccagca acgaaaacta tattctgctc 120
tatgtgattg ccgttttgct gaatattgtt ctgaaccttg cgcttagtat caaaatcgct 180
tcgacaaacg gagccaaggc gttagtatct ttgggtaaat ggattatgcc gattgcggga 240
gttgtatatt tgatcccgca ggtatattcc gtactttttc ccgctaagac tatgcaagat 300
acttattggt atgtctttat tggcatttta tttattgtca gcggcaatta tttccccaaa 360
aaccacatca acccctatat cgggctaaag tttccatggt tattcaatga tgaagaaggc 420
tggtacaaga cgcatcggct gggcggctac acatggatat tagccggtat tgtcagcatt 480
cttcatccac tacacaatct tgtttttgta accgttccgc taatcatttt tctggttggc 540
attgtcccgt tggtctattc gcttgtcctc tattttaaga ggaaacgaag caattaa 597
<210> 154
<211> 1947
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1947)
<223> ICBIDGAJ_00138
<400> 154
atgatgcaaa tacaagaact tgtgctatat ggacgcaatg gaaaagtccg ccatttaccc 60
ttttcacttg gaacggtgaa tattattact ggaaaatcaa aatcgggaaa atctgctgtt 120
ggtgatatta ttgattactg tatgggtgga tcatcttgta atattgccga tggtgtggtg 180
cgagatacgg ttgactggta cggattgctt ttacaatttg aagatgaacg agtttttgtg 240
gctcgaaaga acccagaaaa aggacagcaa acaacgagtg actgttacat tgaagtaggc 300
aaagaaatcg aatccccaca aacgggcgaa ttttcttcta acacaaatgt agacggaata 360
gaagaaacac ttacccgaag agtaggaatt tctgaaaatt tgaatattcc accagaaggt 420
caaagcagaa agtcgttggc tgcaaacatt cgacatgcgc tgtattattg ttttcaagga 480
caggacgaaa ttgcagccaa gaactttttg tttcatcgcc agtcagagaa tttcattaca 540
caggctatta aggatactat cccgtatttt ttaggtgcag ttagtgaagg ggctttggct 600
ttagaaaatg agcgaagcat tcttaaacgg cagttggtta ttgaaaagcg aaaacttgaa 660
gagaatagat acttgatggg tggcggttca acacgagcag ctgtgttgat tacagaagcg 720
caacaggtcg gcttgcttga tgcaaatatt cccattgact atcaaaacta tggaaaattg 780
caatccgttc ttgaaagtgt tgaaaagtgg aatccaagta tggaagattt tgacgatgga 840
atggacgaat tgacctcctt gcaaagtaaa ctgcatgaag ctcaaaatga tttgaatgaa 900
atcaaagaaa atcttaatag tgcaaaacgc tattggggag aaacaactgg ttacacaagt 960
gaagttgaac accaaaagtt aagacttgaa tcaatcggat tgtttgagaa attggacttt 1020
aatccgggag aatgcccatt atgttttgga aaattgacac aacctcttcc aagtgttgaa 1080
atgataaaaa aatctatcac tgctttggat aaatcgatcg agagcgttac aagagaacaa 1140
ccaaagttgc gaacttttat ttcaaagttg gaaaatgatg aacaacagaa gcaagaagaa 1200
ataaaaagat taaaaaccga gattgatagc ttataccagc aggaagatga aaaagaaaaa 1260
cttcgtgatt tgaacgtccg tagaggaaaa gttattggtc ggattagtct ttggcttgaa 1320
agtgtgcaga atgatgctac atcggaagct caagagcagc acataaaaaa gattgaggag 1380
agactaaatg aaatagatgg tgcgctaaat agagattctg ttgaggagcg taagcagtca 1440
gcactgtcgc ggatacagca gtatatgaca aaatgggcag aagagctgca gctggagcat 1500
agcgatagtc cctatagact tgacttgaac aagatgactg tagttgtaga caaatcagat 1560
cgccctgtgc cgctaaaaca actaggaagt ggctctaact gggttggagt acatcttata 1620
acctattttg cactccaata ttattttatc gaatcaaatc gtcctgttcc aagatttctt 1680
tttctcgatc agccctcgca ggtttatttt ccttcagaac ttgatgaaca aaagatagac 1740
gaagatgaag ttaataaaat gtacaagttc ataattgaca ggacggagga acttcatggc 1800
cagttgcagg tcatagtggt agatcatact gccggagaag aagatcagtc ccatcagttt 1860
gtcacggaga gctggtggaa agacgataaa aaactcatcc cggatgattg gtatgagcca 1920
aatgaggcat tgattcctgt atcttaa 1947
<210> 155
<211> 168
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(168)
<223> ICBIDGAJ_01359
<400> 155
atgatgaaac tcgaagctat gaagtcttac atccgtgaga acaccctcac ccacttggtc 60
aaggaacttg ttactggagc cgacatggat gtcgcatccg ctgttgagta cgtttatgat 120
atgaagacgc tcagcaaggc tcagttcgca agcaagtact tcggctga 168
<210> 156
<211> 219
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(219)
<223> ICBIDGAJ_01358
<400> 156
atgagtgcta ctgagcgcac agcccgccga tatgcttcct ccatcgggtt tgcggtgacc 60
ggtaggctgg cccggaagcc cgaatgggat ggaaggttcc agaacccgga gatcggactg 120
gacggtgagt accgggttct ggtcgatgag ggagggaacg cctactacgt caacggctgg 180
caatgtgtca tcatcgaccc ggagggcata gtcttttga 219
<210> 157
<211> 138
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(138)
<223> ICBIDGAJ_02137
<400> 157
atgtctttag cagaagtttg cgcactgctg accgtcatca tcggtttgct gacgttgatg 60
gtcaccgttg ccaaagccgc atttgatgct ggttggaaaa tttctaacaa agaacacgat 120
aaaaacaaaa aagattga 138
<210> 158
<211> 567
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(567)
<223> ICBIDGAJ_00756
<400> 158
atgggtttac agatgtacgg tctactccta agcgaaaggc cggcggttcg aatccgcctg 60
aggacactat ttcaaaaaat gcgaaggtca tttttccatg tgaaagacga tcttcgcatt 120
tttcatttgg aacccatcgc cagaatcata gcagtttgcg ttttgaatgc acaagcaaca 180
tccgcaaacg gctatatccc agagatgccg tttcgatggg cactcttttt gaaaattgcg 240
ataaacgcgg aattttgcct ttacaaaaaa gcactttccc ttatatttgc attgcaaata 300
agggaaagtg cttttgtctt gctcacgatg aggttactat cgcaaaggat acggtcaact 360
cccaatagcg aaaagataat acggcagcct tcactttttc agcactacgc actcataggg 420
gcgcagcgtg tcggcggtgt cggggtagtt acccagcagt ttctcggcat cggtccagcc 480
tacgggcagg ggcttggcaa tttcccgctc ccgcaggttg cagagaacca gcagctccgt 540
ctcgccgtcg taccggcgat aggctaa 567
<210> 159
<211> 168
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(168)
<223> ICBIDGAJ_00757
<400> 159
atgtgcagag catttgaaga agtgagagaa gaaacaaagc atgagcagtc gattgaaatt 60
gcaaaatctt tgctagaagt tggaaaaatg acctatgaag aaattgctcg gtcggttcag 120
cttcctgttg aagaagtaaa ggcactggat acaaagaaac ccgcctga 168
<210> 160
<211> 1452
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1452)
<223> ICBIDGAJ_00202
<400> 160
atgtcttttt cctcacccac atcccgggca cagcgcagcc gcaggatttt gccctggctg 60
ctgtacctgt atgcccttgt gctgttcgcc atgcactttg tccgcatttt tgacaactcc 120
ttctggggag atgaggggtt cagcatcggc cttgcccaaa tgaatgtttt tgaaatgctc 180
caagtcacag cggcagataa ccatccgccg ctgtactatc ttttcacaca gctcctatat 240
catcttctgg gcaatcacgg atatgtctat catctgtcgg ctctgattcc ctatggactc 300
gttctgattc ttgcctgtac agtgattttc agacagttcg gattgattcc cgcagttgtt 360
gtttccactt ttgcctcttt gactgatacc gctatcatgt tcaatgtcga ggcccgaatg 420
tattcactcg gcgctttctt tgtgttagcg gcctatctgg cactccataa cgttcttcat 480
tccggtaaaa cctccgattg ggtcattttc agcgtcgcct ctctttgtgc cgcttatacg 540
cactactatg ccctgatttc cgttgcattt ttctatctgg ctctgctttc tctgcttccg 600
caggataaga gcagcttcaa aaaaatcctt atcacttatt gtgccgcagt ggtcgtctac 660
cttccctggc ttctggtatt gcttcccact ttcaaacgtg ctgcggcaga ctggtggtcc 720
accttcattc cttctccgat caattgtatc ggattcttct tcaatccttc ttggacagtc 780
ctcattttcg gtcttgcatt ccttctttat ttcacagcac aggccaagtt ctcctctaac 840
tggctcttcg cacctgatac gatctggctt ttgaccggct tgctttctgc cgccggcacc 900
tccgcagtcg ggctgatcgt ttcacatgcc tttcgcccgc tttttctcgt tcgatacctt 960
tatccgctca ccgcagtcgt ttacctggtt tttggctttc ttctgtctaa agtccgttgg 1020
agaaccattc tgtccagtat tctgattttg ggaacgctgg tgtgcagtct accggatttc 1080
taccaaacct atcagcggga aaagcgcatc gaccttgcga ccacccagtg tctggaagtt 1140
attaccccct ctcaggatgc agttctttat acaacgaact acttcctaga ctggacactc 1200
tttgattatt actttccggg tcgtgtccat gctcaaatcg aatcctccaa tacttctcag 1260
tgcttcactt cttcgcagcc tgagatctgg ctctttatgg aacatgcgct ttctgatgcc 1320
gaattgaatg cagcctccga caatggttat tctcacacca atgtctgtaa cagtacattt 1380
gcagaaggcc ccggtgaaga ttccttttat tacatctaca aatttcaaaa atctgcaaac 1440
accgccccgt aa 1452
<210> 161
<211> 543
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(543)
<223> ICBIDGAJ_01338
<400> 161
atgcgtgaca actgcgtgat tttctcgaca ccggaacgtc aggaactccg ggtcgtgttt 60
gacccggacg gaaccccgtt cttctgcggg cctgatctcg ctgcgattgc cgggtatgag 120
cagccgagga aagccgtcac cggcggcaac aagggagtga accgtatcga ctccgtgctg 180
cggaaggtgc cttgggacaa cgggatgcgg aaaggccgct gcgagttcac ctgcttcagt 240
gctgagaacg ccgtgaagct cctgtgccgc agaccggctc cgtatgcggc gattcgctgg 300
ctggaggatg aggtcatccc gaaaacacag gaaatgggcg aggaagttgc gcgggcttac 360
cccggatgga acaagcctcc ccagcagaag gaaaagcagg agcaggacgt aacgattgtg 420
gaagtccatc caaagcggtt tctggagcag gttccggcag atggcgggtc gctcatcgaa 480
agactggaca atatcatctt ggaatgcgtt ttgctgaaga aggaaatcag caaggcaaag 540
taa 543
<210> 162
<211> 1395
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1395)
<223> ICBIDGAJ_00778
<400> 162
atggagaaat ttaccattgt cacacaaggc agcgctacct atctggaaag aacgcttgga 60
gcagatgaac tgttggatga agtggatcgc ggaatgctgg tgtcgaacca gatcagcggg 120
atgctgccgc tcaacatcca gtggatcaat gcggactgca gattactgta caatatcacc 180
ggtctgacgc cgcttgtaca ggcggcgcgg atcctggagc atgagacacg gctgagcaat 240
ttctttatgg cactgtgcag ggcagaaaaa gagtgcgacg agtatctgct tgacccgcac 300
aaaattgacc tcacaccaga gcatatttat ctggatgctg caggccatgc atatgtgatg 360
tatgttccgg tacaggcagc gccggataaa tacactccca cggaactggc gggttatgtt 420
ctacgcatgg taggcagaca gatgcctcac gacagccgtg tggtcggcgt cctgtctcgt 480
cagctgctgt acggcgagaa gttctccttt gtcgatttag agaagcagat agaagagatc 540
ccgacgcagg ctgagccgtc aaaagttgct tatgagctga aacctccggt cagtgaaccg 600
ccagtccgac agtcggaggc cggtagtgct tcgttgagac cggaacctgt aatgtataaa 660
ccggaaccga ctcccgccca tgtaccggca gaacagccag tgcaggatag tccgtttgca 720
gcacagcagg gaggtaatcc ctttattgcc agccagccgg agccgcagcc gaagaaggaa 780
caaaaggatg aaagggccga aaaggctgag aaaaaatctg aaaaagaaaa gaagagcggc 840
gggctgttcg gcggactgtt tggtggaaaa aaggacaaga aaaagcactc ggcagaagaa 900
caagataacc cattccggca ggaagcaccg gccccggagc agtcggcaga taagccggcc 960
cccgcagcag ctgcttatgt gccgccacag ccgccagtgc agcaggccgg cggccatact 1020
gtggtacttg cagcaggcaa tggcggaact gcccgcacga cgctaatggg ggctggcagc 1080
tccggcgggg tcgaagagtt gtatttggta cagaaggcga cgaaccagta tatccatgtc 1140
acccatacca atttccacat tggccgtgca gaggacgtag tggactacac ggtgcacacc 1200
cagaactgct atctgggcaa cgaccatgcc tacatcctaa tcgagaacgg cagctactat 1260
attgtggata acaatacgca gaaccacacc tacctgaacg agcagcggct ggagccttcc 1320
aagccaacgc agttccatgc gggcgatacc atccgtatgg cagatatcgt gttcagcgtg 1380
gtggcagggg cttga 1395
<210> 163
<211> 1398
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1398)
<223> ICBIDGAJ_00329
<400> 163
atgaaaaact taaagaatat tgtgcttttt acaataatat ccttgttact gttctgcggg 60
tgcagtcagg aaaataaaag cgcttcggat acagtgaatc cgcaagatgg aaaaagtgtg 120
tctgaacaac aagaaactat agtggattct gaaaaagcag cggaaaacgt tacggataag 180
atgagtttgt tagaagctgt gggagagggg catgtttact tgacattccc caattttgat 240
gaactttcag taggcgaaat cagagatggt caatcaaaca aaagcgttct ttttgatgca 300
cagggaatgg ttcatcacct gtttgaagac ggaagcaggg ttgtgtctgg atactataat 360
ggtatgtgct tacttagtaa tgggatgatg gcaacagaag acggaacgca gctgctggta 420
tcatggcttc cagagaatga aaaaattatc cggtttgcaa aggatgaaga gggcgttctt 480
ctatggtcga taaagagaga agatggaatc gatgggacaa aagttacgtt taccgcaaga 540
aaaatggatg gctcaatctg ttttcaatgc gatacgacac agccagagtt ctctgagctt 600
aatccgaatg atctttatga gacacttgtg aatgctggat atgatatgaa tgcagaagga 660
atctctactc cgttcattta ttgcggagga acgctttatc gtgtccgagg atggaatgga 720
tatgtcttta taaacattgc aaatggaaaa ctccattata tttctgaatt taatgcatgt 780
cagattagaa tggaaaatgg tgtgatgttt cagacagcac cgagcattcg agttttggac 840
gatgacttta atgaactgcc ggagtggaag agtattaaat cacagcgaag tggaacgcca 900
gtattggcag aggggctgat ttaccttgat gcaagaagag atacaggtga gtttgagaaa 960
tatccatcag gattttatga tattcacttg aactgtatca tcgatttgag ccagtataac 1020
attcagccgg ttacaactga tgaaccacga tttatgaatg ggtatgctgc attgcaaatg 1080
ctgaatcctg atggggttcc tttttgggga atcataagaa aagatgggac gtggagtgtt 1140
gaaccgcaaa aggggacaat aaagagcata tatccaacga aagatggatt actggtaaca 1200
gtgagtcaag aaaatgacta ttatacgaca atcaatcagg tgggacagaa tcttagtgac 1260
gtagaaacgt ttgtatttga tggagtaaac ggatattgga attcggccta tgagatttat 1320
aatgaatcgc tctatgcaac aataaatgga gaaattgtaa gaatagataa aaatggttcg 1380
gctgaatttt tatgctga 1398
<210> 164
<211> 1182
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1182)
<223> ICBIDGAJ_00450
<400> 164
atgaaaaaaa ctgaattact tataaaatca cgagaagcca tgatgtcggc tgttcagttg 60
tacaataatc ctcaaatcac gtttaaatca gaaacattta ttacattggc aattattgct 120
tggacttatt tacttcatgc attctatgcc aatgaaggca tagattaccg ttattttcat 180
aataagggaa agaaaaaagt atatgataag acaaagcatg gagcttataa acattgggag 240
cttgagcgtt gtctggattg tcaagattct ccaatcgatt ccataactgc tagcaatctt 300
aaatttttaa tcggaatacg gcacgagatt gagcatcaaa tgaccaaaaa gatagatgca 360
tctatcagtg caaaacttca agcgtgttcg atcaattaca atttttacat caaaaaattg 420
tttggaaatg tatttggagt tgatcaggaa ctcggacttg ctattcaatt ctcacccata 480
gaagccgaac agaaagagca acttttccgc aatgagaaac tatcaaataa cataaaaaac 540
tttataacag aatttgagga ctctttaagc gaggatgaac ttggtaatac acattatgca 600
tatcgtgttg tatttgcacg cgtagatgga aagcgtgtta acagcacaac agatcaggtt 660
attacattcg tacgagcgga tagtccgcaa gcgcaaggat taaatgctgc gtatacacta 720
ataaaagaaa ctgaaaagaa aaaatacctt tcaaaagatg tagtcaaatt gatgaacgaa 780
aaaggatata cttggttcaa cactggagat atgactgcat tttggaagaa cgagctaaag 840
agtagagaaa aatatggaat ctatattacc aaaaatcaat ggatgtggta tgaaaactgg 900
cttccagttg tagaaaaaca ttgtcaagaa aaggaattgc aaagacacga agaagccaaa 960
atcacatata ctccatccga aattgttgat attatgaaaa agaagggata ttcccgtttt 1020
aatgtatggt ggtttaatca aatatggaaa aacgagctcg gcatcaaaaa agaaagcaca 1080
gaatatggct gtcctttgaa atatggacat tttggatggt atgaatcaat cataccgcta 1140
atagaggatt actgcaaaaa gaatactgga agattaaaat ag 1182
<210> 165
<211> 270
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(270)
<223> ICBIDGAJ_01291
<400> 165
atgagcgccg ataagctgac ggaagcgcgg gaggcagcgg aaagctcgct ggggttcaaa 60
atcccggatg tggtcgccac cagcgttctc tggtatgccc ggcgcaaatg tgagctggca 120
gagcagccgg agagctacct tccgcttctg tacgaaaccg agctgaccga ctactatatg 180
cggttggaaa tcaatcagaa aggagaaaag caacgtgagc aacgaatccg cgaagcccga 240
aattccgcag ttcccggaac tgacatttga 270
<210> 166
<211> 615
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(615)
<223> ICBIDGAJ_01292
<400> 166
gtgagcaacg aatccgcgaa gcccgaaatt ccgcagttcc cggaactgac atttgaggaa 60
gaacggcatc tctactacct gaacgggctg gaagtaccca gcgtgaccac cctgatgaag 120
ccgctgtcca gtgacttcta cagcacggtg gacccggagg ttctgaacaa ggccgcaaag 180
cgcggcacgg ccatccacaa tgcggtggag aactacgcca agttcggcat tgaggacatt 240
ccgccggtgt atgccgggta ttttgccggc ttccgggagt ggtgggatag ccgcaagccg 300
gaagttctgg cgaccgaaac caaggtctac cacaaaatcc tgcggtatgc aggcacggtc 360
gatctgctgt gcatcatcga tggcagggtg acgctggtgg actacaagac atcggcacag 420
gtgaacagca agctctgcgc tgtgcagctt gaagcctatg acagggcatg ggagagccac 480
gacatcaagg tcgatgaccg gctgattctc cacctgtcca agaagggcta tcaggaagtg 540
cgctttcccc ggagtgggaa gtgctggtcg gtgttctcgt cattgatgac aattaagaac 600
tacatgaacg agtga 615
<210> 167
<211> 711
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(711)
<223> ICBIDGAJ_01293
<400> 167
atggaaaaag aaactatggt ggcaatcgtt ccgaagaccg aaatcgttga tgagcagcag 60
ctctcccgcg atgtgaccga catcgagttt caggcggagt ctctggttat ccagaccgat 120
gaagattacg cctttgccgg cgagttcggc aagatgctga agaaaaaagc gtcgcaggtc 180
acgacgttct tcaagcccat gaaagacagc gcctatcagg cccacaaagc ggtttgcgac 240
cgggaaaagg ccatgctgac cccgctgcgc aacgccgaga agacggtcaa gcaggtgatg 300
agcgcctaca ttgcagagca ggaacgtaag cgccgggaag ctgaagaagc tgctcgacgg 360
gcagcggaag ctgaacggga gcgcaagatt caggaagcgg ctacgctgga agccgcaggt 420
gatgcagatg gagcggaggc cgcctttgag gaagcagcca tcatggatga tgctgcaagc 480
tatgcggtag tgcctgccgc agccaccccg aaggtctccg gcgtcagcac ctcgaaagac 540
tgggaaatcg ttgaaataga ccccaaggcg gtcccgctgg cggtggctgg cgtcgaactc 600
cgcccggtcg atcaggccgc tgttatgcgc ctcatccgta cctcgaaggg ccagatcgag 660
attcccggca tcacctatcg tcaggtcgca aaaatgagct tcagggggta a 711
<210> 168
<211> 753
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(753)
<223> ICBIDGAJ_01295
<400> 168
atgccgtgga taagcgtaca tcaggaggtg gacggtacga agctccgtag attataccgc 60
gccatcgggt gttccaagtt tgaagccctc ggcatcctga acttcctgtg gttctggggc 120
atgaagaacg ccgatgagac cgggatggtc aaggatgcag acctcgaagt cctgagccga 180
tacctgtacg gctgcggcga ggactgccag ctcgacatgg gcaaagtggt tcaggccctt 240
gtggataccg gctggattga tgtggcggct gacggctttt acatccacga ctgggacaca 300
tggcaggaac agtggtataa gctccagaaa aaccgcaggc tggatgctga acgaaagcgg 360
aaagcccgtc agatagagcg agaggccgca aagcctacac cgaagacccc ggagccggaa 420
cagatggaac ctcctgtgga accagaagtc aagccgcctg caaagccgaa acccgataaa 480
aaatcctatg cggagttcgt gaagatgagc gaagcaaact acgacaggct cgtgaaactg 540
tacggcaaag cctttgcgga cgcctgcatc gtagaactcg atctctacaa gggggcgaag 600
ggcaagaagt acaaggatga ctaccgggcc attttgagct gggtagttga ccgtgtgaag 660
gaaaagaaac cggggctgct ccagcagagc atgagggagg cagcaccgga tgaagacaat 720
ccgttcagag agtggggtga gcagagtggg tga 753
<210> 169
<211> 402
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(402)
<223> ICBIDGAJ_00911
<400> 169
atgggtttgt atgagggcat caaagatgtt gccaaagttg tacagcaagc agataacatt 60
gaactgtatc ggcaactatt ggatttaagt gctcaagcgc tagatttgca agctgaaaac 120
ggtcaattga aggaagaact tcatgaactg aaaaagaaac aagatttgga agataaaatt 180
attcggcacg gtgcactgtt tttgcaattg aaagaccaac cggaagaatt catgtactgt 240
acacattgtt gggacagtga aaagaacatc atacaactcc ggtgtgatag tgatggtgaa 300
ttttactgtc cgcactgtca tatatccgga atttatgatg aaaataaata taaccagtat 360
caacaggcaa tgttaaaatc aatggaacca gtaacttggt aa 402
<210> 170
<211> 201
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(201)
<223> ICBIDGAJ_01349
<400> 170
atgggtttga acagagtaag agtcgattct gtagccaagt tgcagaagaa gaaaacgatg 60
gcggaattgc aggaggagaa tgaagccctg aaaaccaagg tttcttctct ggaaaccaac 120
ctcgataata cccagatggc gctgtgcgac gtgtacgaac agctcatcgc ggtcacatcc 180
gccgcagata aggaggcata a 201
<210> 171
<211> 942
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(942)
<223> ICBIDGAJ_00339
<400> 171
atgacattgc aagacctgat gatgctgtat ggtgtcaccc tgggcaaacg gcgcactgca 60
aagcagaaat atctttttgc ccagcagctc aacgagagcc taccgccgct gggctggccg 120
gtgcgggttc aacagaggga aggacggttt tccaagatcg aaaacctgat tgccggggat 180
ctggcaaatg caaaggtcgt cattgcggtc ccctttgata cgccggcaaa ggcgctgcgg 240
ccccagaaat actatccgtt ccatccggac aaaaatgttc agcagcgggg gagagacctt 300
gcactgcaat gcgtgctgga actgctctgt ttcggagcgg cctgcctgat gttctggtcc 360
ggacggggaa ccggtgccat gctgccccgg acgctggcgg cactgctgct ggcgggggta 420
ggtgtctggc tgctgctgcc ccatgcaagc ccctgcaact tcagccgctg ttccggtgcg 480
gtcgccactg ccgtaaagct ggcggaggac ctgagcggtg aggagaacat cgcttttgcc 540
ttctgcgacc atgcagtgga taactatgac ggcttccggc ttctggcgca ggaggtgcca 600
actgcggcaa ctgttctgct gctggacaat ctgaccagcg gcccggcggt ggcgctggcg 660
cacggcgagt atcggaaaga ggcggcggaa cagctgtgca gtttgctgtc ggcggataag 720
gtctatgacc ggaactaccc ggaggaacag cggcagcgga atctgctggc gctctttccc 780
agagggatga tgctcagctg tggacgagtg gaaaaaggcg aatttgttgt ggagaatacc 840
tgctgtgcac aggaccatgt actggatctg ccccggatgg agcggatgga acgggcgttg 900
gccgattttg caaaacagaa agcaaataag aaggagaact ga 942
<210> 172
<211> 249
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(249)
<223> ICBIDGAJ_01345
<400> 172
atggagcaca ttgaattttc atgtccgccc ggtgagctgt cctgcatcat cgggaatttg 60
ttcgtcagcc ttgaacctcc ctgcaaatat gtgcgaagta cgcacctgat gctctgcggc 120
atcactcaca gcggaaacag cggtcgcctg actgttttgg gcgaccgctg ctctttctat 180
gggcttgcca gcgatttgga ggctgcgagg aatggcccct gcctcgaaag aaggtgtgac 240
cgtggctga 249
<210> 173
<211> 393
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(393)
<223> ICBIDGAJ_01759
<400> 173
gtgacagtag gaaaagcaat cgaaaccgca gaccggctgc ggcccaacaa cgggtttgac 60
cgcgagctga agatcttatg gctgcggcag gcggatgcgg ggctgagaaa gagcgtggtg 120
gacaagagcg acaccaccga ttttgatgcc gtgggtgcgg acatcttata cgaccgggag 180
caggagcttt tgcggcagga cgcggagttg ctgctgccgg agccctacaa cagctactat 240
gcccactatc tggcggcaca gatggacgcg gccctgggcg agaccgaccg ctatgccaac 300
gagatgcagc tggccaacga gaaccagcag gagtttgcag cctggtgcag gcacacctac 360
ctgcccagga tggccacgaa gtggaggtac tga 393
<210> 174
<211> 1401
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1401)
<223> ICBIDGAJ_01755
<400> 174
atgttatttg ataccttacg gagaaagaac caggcggaac aggaagagcg ggaatggaac 60
gccaaccgcc cggcggacta tgtgagccgg aacaaggacg caatggacag cctgaccggg 120
cagatcggca gcgggttcga ctgggacacc ggcagcaaag cctaccagca gtaccgcgcc 180
caggcccagg ccaatgctgc cgccagcgcg gagaacgccc aggccaacgc ggcgatgctg 240
gcgggtgggt atggcagcag ctacgccgac agcgtggcaa agcagggcca gcagcaggcg 300
ctgagcggca ttgacaatgc ggtacccggc ctgagaggcc aggcactgag cgaataccag 360
aaacagcaga acgacctgct gagtgccctt tccggcatgg ccaacaccga ggcgctggat 420
cgcagtgcct acggcagcaa ttttgccaac tacacggcgt ggcagaattt ccttgccaac 480
cagagcgaac aggcccggaa cgagaacgac aactactgga acaacctctg gaacacggta 540
aagaacatcg gctcggcggc tctgacggcc tacgatgggt acaaggggta cacgcagcag 600
cagtgggaga acgactttgc ccgggaacag tgggagtaca acaagaaccg caccgaccag 660
agcgatgccc tgaacgccta tcagcaggcg ttcaacctgt acacccaggg agccggggat 720
gcttctgccg atgtgctgaa ccggtacggc ctgaacaagg atgcctttgc caactacacc 780
ggcgcaccgg tgacccggga cgatcaggca agcgtgctga ccacggcggc ttcccttgtg 840
gcaaacggca acagcgaggc ggcggccaac ctgctgaaga tgtacgggct ggacagcaat 900
gcagccggtt cttacggcac cattgcaaaa cgtcagctgg cgacccagct ggcaaaggcg 960
gcagctacga agagcagcag aagttcgaga agttccggcg gctccagcaa gagcggaagc 1020
gggtggacaa acagccaact gctgacggcg ctgggtaagt atcagagcct gaaggatgat 1080
gacccgacca agagcgtcta tgcgaacatt ctggccagcg ccggaatgct gccggacggt 1140
gacacgggca caacagcagc gaccggaact ggcagcgggc tgatcgcccc gctggcgaat 1200
ccgaacaagt gggccctgcc cgggggaacc acgggaggga gcacgggtaa gagtaccgga 1260
atgccgtaca gcaatgccct gagctatgca aaggggtgga gtgcagaagg ggtggattcg 1320
gatacgatct atgccaggct ggtcaacatg ggcataaatg atgacgtggc ggccaaggtc 1380
tggaatgcga tgggatggta a 1401
<210> 175
<211> 234
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(234)
<223> ICBIDGAJ_02196
<400> 175
atgaataccg taacacaaac catgcagttc cgtcaatcac ttttgaacta cgcagagaag 60
ggcggcgtga accgggcagc aatcaagtat aatatgaacc gcaacgacat tcattctctt 120
gccaatagat tgtaccggcc catcatccga actagcgcac agaagcggag ctttaacgga 180
tcacaaactt ttgtaggaga aactcaaaca cagagctggt cgttctttag atga 234
<210> 176
<211> 201
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(201)
<223> ICBIDGAJ_01757
<400> 176
atggcagata ttacgaggct tggcgagatc gccatgccga aactgagtga caacatggcc 60
ccggaggaca ggcggagcat caacaactac ctgatgcagc tgcgggacca aatgatatac 120
atgatgcaga acctggacga gacgaacttc agcgacacca tgcgggacaa gctggtggct 180
atggggctga aggtggagta a 201
<210> 177
<211> 780
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(780)
<223> ICBIDGAJ_01756
<400> 177
atggcaagag gagaatggtg ggagtacctg atcccgggcc acaatgtggg gctgatggta 60
ggggatgtgt atgacggcat taccggcaac agcgaaaaga atgcgggcac cggcgtgttt 120
ggaaccagaa agaacggttc caacagctac cagtacgccc agagcaatga ccgggtgacc 180
acggcaaaga acaatttgga ttacatcaaa ggacagaagc ccggggagta tcagagcgag 240
tacggcagcc agatcagcgg cacgcagagc cagctggaca agatgaaccg ggacggcttt 300
tcttacgact acaccaagga cgcagcttac cagcagtaca agaaccagta cacccggggt 360
gcggagctgg ccagcgagaa cgctgccgcc aacgcttcgg cccgcagcgg cggctacggc 420
aacagctggg gcacttccag cgggcagacg gcctaccaga gcaccatgaa cgggctttcg 480
gacgtggcag acagcttata caaccaggct tacaacgaat atgccaccaa aaagagtgac 540
ctgggcaacc ggctgagctc tttgcagcag caggaaaagc tggcgcagga tgcttacaac 600
acccgcctga acaattacta tggccagctg aacagtgctc agaccgagta tgccaacgcg 660
gtgggggcca accagaagaa ggatgcgaac aacaccaact tctgggggaa cgtattgcgg 720
atcggtgcac agctcgccgg gccgcttatc gtgaagatga tgacgggtgg cttgctctga 780
<210> 178
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_01751
<400> 178
atgaaaacgc tgaacaacct gaaactccgc atcatggtgc gggcattccg catccggctg 60
aacaacggcg aagcctttga ggcaatcgcg gcggattacc ccgccctgac cgcagatgac 120
ctggaagcta tccacgtcca gctgaccgag aaggaggcgc agagcaatgc ccagaacaat 180
acttga 186
<210> 179
<211> 219
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(219)
<223> ICBIDGAJ_01287
<400> 179
atgaatagct ccaagctcaa gggcatccgg gtcgagaagg gaaagaccca gaagaatatg 60
gccgaattga tcggcaaatc gcttgttacc tactccaaga aggagcgcgg agaagtcgag 120
ttctccaatg aggaaatgag cattgtcgcc aaggcgcttg acctgaccag cgatcaggtc 180
aacgctattt ttttcgacga caacttaccg aaagggtaa 219
<210> 180
<211> 633
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(633)
<223> ICBIDGAJ_01285
<400> 180
atgacgaagc aatgtaccgg ggacgagctt atcgtcttcg atgatatgcc cattggtaaa 60
tccttgagtg actactggcg ctggaacgcc tcagacctgc tcaacaatac cctgcggggc 120
tcctactgcg agttcatcgt atcggccgcg ctgggcgttg atctgagcgg aaccaacgat 180
gactggactc cctacgacat ctctttcccc tacaactggg tatgtaatgg cgaggcccgc 240
gatgaagtgc gcatcgaggt caagagctgc gcatatcttc aggcatggcg gcagggcgat 300
ggcaggctgt ctaacatcca gttcagcatc cgtccaacaa gagcttggga ctccatcaac 360
ggctatgctg aggaggtcat gcggcagtcc gatgtgtatg tgttctgcct ctataccgag 420
accgtgcggg aacgggccaa cccattggtg ttggatggat gggacttcta catcgtaccg 480
actcatattc tggacgagca gtgcggccct cagaagacca tctctctcac tatgctgcaa 540
aagctggacc cataccttgt agactatggt agcatccgtg atgccgttgt cgattccttg 600
aatgtgtacc cccccccccg atattttgca tag 633
<210> 181
<211> 1002
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1002)
<223> ICBIDGAJ_02195
<400> 181
atgtactaca aaatcaggaa tgatgtgttg ttccgaaaat atcagggaca tggctatata 60
acagacaatt cagaatacgg ctatcgtatg ctcaatgatg cccgtatata tccgggtgaa 120
aaatatgtct ctgccagtgg agctgtcatg ttgagtatgc tgagcaaatc tcctcgcgcc 180
attgatgata ttgttggaga tttgtcgcaa atcttcactg gtgtcgagta tgaaacgttg 240
aaacaagata ctatagagtt tttcgactgg tttgtagatg agggatttct tagttgtggt 300
aaaacggtcg acacttgcac agatcgattt gttgcagata tcctgagacc ggacaatcgc 360
aatccggctc aagatggtat ggcaagaagt gactgcactg gtggagaaat cagtccaaat 420
gattttctta gaagcatcca tatcgagatt gctgatgcat gcaatgagcg ttgcgtacat 480
tgctatattc caaatgaacg caaaaacaac gcgattgatc ccgccttgtt ttatcgactc 540
atcgaggaag ggcggaagat gaacatcatc catgttacgc tgtccggagg agaacctctt 600
cttcacaaag atattttagg ctttttgaaa agatgtagag aactggattt gtctgtaaac 660
gttctgtcga atctgacttt gttgacggat gatatcctat cggaaatgaa gaaaaatcct 720
cttctctctg tacaagtttc cctttattct atggatgcca cagtgcacga ttctatcaca 780
aagttaagcg gaagctttga aaaaacaaaa gcgggagtcc ttcggttgtg tgatgaaaat 840
atcccggtac agatatcgtg tcctatcata aaacaaaata aagacaccta tgttgatgtg 900
aactgcaccc catttgttag acagtatggt atactgttta ggaaatgggg tgtttttgta 960
tgccaaaggg acaacgaaag tacaacggag ctcaaaaggt ag 1002
<210> 182
<211> 180
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(180)
<223> ICBIDGAJ_01289
<400> 182
atggctgaca tccaaacgct gaagaagttg cttgccgaag aatatggcat cacaaccgca 60
agagaactcg acgaagccat gaagaaaatc ggaggattga atatcggcgt gtttgcatcg 120
ccggtaagaa aggatggaac gaaacatgaa aaagtacgca gtattgcacg agccgggtga 180
<210> 183
<211> 1329
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1329)
<223> ICBIDGAJ_00909
<400> 183
atgaaaaagc ctaaaattat cggattgaat acaacgtttg cgtctttaaa ctatccaaac 60
tggatagaaa caggattttc cgagtctgta tcactccttg actatgaagc ggttgtaata 120
aatccggctg aattattgag agagtatggt tataaatctg ccgaatacaa agattatcgg 180
ttgttgtctg aaacctgctc aagacaaatt gtagctgatt ttcatcgaat ttatggtcag 240
gtggttgaac tgctaagaaa tggaaaaaac atctttgtaa ttctaaacgc ccccgatgtg 300
ttccgtatca gagaaaactc aggggcaaaa tatagctttt tcgattgttt ttcttttctg 360
ccagtacaaa tttggataga gcaccttaaa gggcatgagt tgattacaac ttcagagccg 420
ccttatgacc tctattttag aaaaaataaa gatgcactat tctatgaatg tgtaatagaa 480
cgcctttcca gtgcagttcc tcttgctaat attcggggaa caagtaagct gatatcagcg 540
tatgtggaat atggacatgg aaaaattatt tttctgccac cagttaaact ggagggcgat 600
gttggaacaa aggctgcatt ggaagtaaat ggctcaagat ttatagaaag cattatggaa 660
ttacaccatg cactttctgc gccaagtgag acaaacgaac ttccctcgtg gacagaaaat 720
tttcatattc tgaatgaatt agaggctatc cgactaaagc atcagtctga agctgaaatg 780
caaaagctga aagaaaaaat tgaggcagag caaaaggcaa ttgacaatat tacaaattac 840
aaaagattgt taaccgaaac cggagaaccc ctcgaaaata ttgtaaagca ggttctttcg 900
gagcttggct ttgaactttg catggcggaa gaaaaacgca gtgatgtgat tgctaaatat 960
aataacattg atatcgttgc tgagattaaa ggcgttggca agagtgccgc tgaaaaacat 1020
gctgcacagc ttgaaaaatg ggcttcgcag tttttaatag accatgggca tcaacctaga 1080
gcactgctga ttgtaaatgg ttataatacg ttacccttgg atcagcgcac agaagaagtg 1140
tttcctgatc agatgttgaa atacagcaca agccgcgagc agacgcttat cacgaccaca 1200
cagcttttat gcctgtttgt tgaaattcaa gagcatcccg attgtaaaga agaacgaatt 1260
caggagcttt tgtctacgat tggtcggtat aaccgttata cagactattc tgagtttatt 1320
acacaataa 1329
<210> 184
<211> 711
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(711)
<223> ICBIDGAJ_00908
<400> 184
atgtcgttta tcatcaccgt ttataccagc gaagggattg tcatggcaag tgacagtaga 60
tcaacctata acttcacaaa gcaacttggt aatggaaatt ttgaaacctt gtgtggtgca 120
cagattactg atacaaccta taaaacgttc cagtgtaatg agcatatcgg catttccact 180
tgtggagatg cgagtatcaa tcaaacgcca attgctggat atattgaaaa attcattcat 240
gaaaaagtca atgcagatag cagtgttgga caagtatcaa atgatttgct gaattacttt 300
agcaatgtca atccacactt aaatactcat tttattattg caggatatga ttctaataat 360
acactacctg ttgtgaagca actttttgtc gctgatcaat ctataaaaaa ttttagtacg 420
aatttttccg gtgctgtttg ggatggtgaa accgcaactc tatccaaact gtttacacag 480
ctttatgcca aaaatcctga tgaaacctat tgtgccattc aaaatcatgg aataaatttc 540
aacttcttca acttgcaaga tgcaatcaat tttgcccagt atgccgttga tgtcacgatt 600
aaaacgatgg cttttgaaaa ctgtgtaaaa accgtgggtg gtccagttga tattcttgta 660
atcaagccga ctgaatcttt ctgggttgcc agaaaagaac tacatgcgta a 711
<210> 185
<211> 891
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(891)
<223> ICBIDGAJ_00770
<400> 185
atgctgattg taaaattgat ctgtctagtg ctgggtacgg cactggcagt gctgttcatc 60
cttttcaccc tgcggggcag aaaagaggac tggcgcattg aaggcgtgcc gcagaaggaa 120
ttcagtgata aagaactgtg ggcggcaggc tttgccatgc agcaactgcc ggtgttttcc 180
atggattcgg ctgtcggcaa aaaaatgatg tcggcttctg ccattctgca cccggaaaac 240
ggcggacgtt ttgtggaata ctgggcgcgg ctgtactggg cgcgcacgct gtccatgtcg 300
ctgctagtgc tggcgctggc gttctgtgct tcggtgttca tggacggcta catggtattc 360
gttgtgctga tcgccggtgt ggcaatggtg gccgtcatct attccaacgg tgcaaatgag 420
atgagcaacc agcttaaaaa gcgcagcgaa gagtgcatga tggagttttc taacgtggtt 480
tccaaactga cgctgctgat gaactgcggc atgatcctga aggaagcctg gtacatcgtg 540
gccaagagca agaagggtgt catttacgac ctgatgcagg aagcctgccg cgaaatggat 600
aacggcacgg ccagtgccga ggccatttat aactttggcg tccgcaccgg ttcgccggaa 660
gtgcgcaaat ttgccagcat catcatccag aacattgaaa agggcggctc ggacgtgacc 720
accatcatgc gccagcagtc ggatgagctg atctcccagc gccgccagat gctgctgcgc 780
cgcggcgacg atgctgccgc acagctgctg gcacctacca ccatcgtgct ggtgggcgtc 840
atcatgatca tcatggtggc ggcaatgacc ggcatgagca cggctattta a 891
<210> 186
<211> 237
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(237)
<223> ICBIDGAJ_00771
<400> 186
atgaacaact tcatgaacaa gctgtatgtc aaggctctgg ttactgccaa catggcaaag 60
aacgagctga agaagatgtg cgaagaggac gaaggcatgg acatcattgt caccatcgtt 120
ctggtggcac tgggcatcgt gatcgttggc gtcgttgctc gtattgcaag tgatgtcatc 180
ggcaaggctg accagcaggt cagcggtttg gacagcacct ttgcccagct gaagtaa 237
<210> 187
<211> 237
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(237)
<223> ICBIDGAJ_00772
<400> 187
atgcgaaaat tatcaagggg tcttttaaaa gcggaaattt tactctggaa tatgggcacc 60
ggcctgaaag aaaaatggcg cagggctgca caagatgaaa gcggccttga tgtgatcatt 120
acggtggcgc tgatcgctgt catgctgatc gtggcgggac ttgttgtcaa gctgctgggc 180
cgggtgctgg agccaacggg cacatcggtt ggaaactttt tgagcggacg cgtctga 237
<210> 188
<211> 636
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(636)
<223> ICBIDGAJ_00773
<400> 188
atggaatgga tcattgcggt atgcagtgcc gggctgaacc ttgcggcagt ctggctcgtg 60
cagaaaaaaa cagggcttaa accggaaaaa caaacgcagt gggcagcggc tttgcttctt 120
gcagcggcgg gcggctttgc cagcggatat atgctggttc tgcgggcggg cacatacccg 180
ccgaatctgc tgcgccttgt gttgctggga acgctgctta ctgcggcagc gtatatcgac 240
gcactgagcc ataagatccc caactggatc gtgctgtgca cggcggcagt ttttgcgggg 300
tgcacggttc tggactttgt gctcagcggg acagacgctg tgcccatggc actcaacagc 360
gttctggcag cagcagtgtt ttttgtggtg tttttccttg tgcggctggc gtcacgcggc 420
ggcgttggat atggagacat caagatgatc acggcagcgg cgctgatcct gggaatatac 480
gggacattca gctttttgct ggtttcgcat gttcttgcgg cggtggcagc cattgcactg 540
ctggtcagca aaaaggcaac acgcaaggac ggcctgccgt ttggcccctt cttctatctg 600
gggtatctgg taacgatttt gacgggaatg ttttga 636
<210> 189
<211> 1338
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1338)
<223> ICBIDGAJ_00774
<400> 189
atgaaaaaaa cgcgtcttgt agcgctggtg gcacttgtgg tggtctgtat tgcgggttgg 60
gcgattctgg gcctgaatac catgaacgat gtcaaaacgc agcagaacac ggtggaagcg 120
gcgcagtatt accgcgggaa aaagctgttc cagctttcac tgcagaacta ccagagtgcc 180
attgcagcaa aacccacaca ggcgctgtac gatgagtatc tggcagcctg cgcggaatat 240
tatgaggact gcccgacgag aaatgtgcgc aataccgaag aatcggccta tgcggcggcg 300
gttgcggcat acccggagcg cgccgattac tgggaaaagt atgcggcaat ctattatgaa 360
gacggcgatt acgacacggt ggtcgatgtg ctgaagagcg cggatgccgc caaggtctcc 420
ttcaatgata ccatgatgca gtactggaac gaggcttact atgcctgcga gacctctgct 480
gcaaattatg aatcgctggc accggctggc atggatggcg tgtatctggg ctggaatggc 540
gaggaaaacg ttcttttcag cagtgcggac ggcgaccttc tggatcagag ctacgcattc 600
gttggcccgg tcgggcagga cacggcggtg ctgtgcagca gctatgaagg cgagagctat 660
gttttccagc tcagcaagag cctgatggtg ggccgtttta tggcgcaggt cgagcaggcc 720
aacggttacg gccagggcct gatccctgtg cagctgaagg gccgctccga ctggtgctat 780
atcgacctca acggccagaa atacctgaac ggctatcagg ctgccggcat gttccagaac 840
ggcaaggcac cggtgcagaa agacggcgca tggatctttg tggatcagac cggtgcacag 900
cagggcgaca gctatgagga aatccagctg accgaaaatg gcagctggct ggtaaacggc 960
gtatatcttg ccaagaaaaa cggcaagtgg aacctatatt cggaggccgg cgagcagcag 1020
ggcgcactgg atgcagacga ggtcgatctg aaccgcggca atggccttgc gtttgccaag 1080
aacggcaagt ggggctttgc agccaatgac ggcactgcgg tgatcgcacc ggaatatgat 1140
gcagccaaga gcttttccgg cggcgttgca gcggtgtgca aggacggcaa gtggggcttt 1200
atcaatggca gaggcacgca ggtaatcgac tatctgctgg ttgaagccgg atatttcgac 1260
gccaacggca agtgccctgc aaagatggac ggcaacgaca cgcaggtgat gctgagctgg 1320
cgtgtgaagc gcagctga 1338
<210> 190
<211> 654
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(654)
<223> ICBIDGAJ_00775
<400> 190
atgaaagagt ggaaacaaag ccttttgcgc gtacaggaag atggtatgga ggccattgag 60
ggcctgctgg tcattacgct gacgctgttt gttctttttt tcatctgggg ttatggattt 120
ttgctgttcc agcaatttgt ggtgatacgt gctgcagatg aaacggccaa caaaattgcg 180
cagacatatg cgtacgcaga aacagacccg atcacgggat atatcagcaa agaagtaaaa 240
gttgcattga gtcccagccg ttaccaaagc ggaaaactgc aagaaaaaaa cgaacagcgt 300
gccataaaat atggaaaatg gcttgttcgc aaggggagtc tggcaacgca ggtcgggatg 360
ccggtcgttg aagcaaagac tgtctacgat ggagttgcac agcgccatgt ggttgtgaat 420
atcacggccg agtacaggat tccgtttggc aatttcttgg agctgtttgg ggtcagcggc 480
acgcgcgttt actatgcgac ggggcgggcg atgtgcacag atctttcgca ctatatcaat 540
accgtggact ataccaagac gttgaattat gtagtgagca acgttgcaaa gaatgattat 600
gttgatctgc tggagaaagt tcttgcattt atcgtgaaga aaaaggattt ttaa 654
<210> 191
<211> 2787
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2787)
<223> ICBIDGAJ_00776
<400> 191
atgaaaaagg acaaaatgat aaagaatacc tgcggcgcaa tctcattgat gcttgcattg 60
ctggtcgtgc cgttttatgc ggtagcgggt attctggtgg aagcaagtag atatcagtct 120
gcattgacgg gcctggatga tgcgatgaac accagtgcac tgtcggtgct gtcggattat 180
gattcgtttt tacaaagccg gtttggtctg cttgcaatgg cgcagaatga tgacccgtcg 240
gtggataatg gatataccgg caacaaagac cttgaggaag cattccaaaa gtacctgaat 300
gcgcaggata cgaccgatac ccggagcttc cgcacaacaa gtgcagcggc ggcaggcgta 360
tatccgttgg cggacacgga tatcttaaag gcacaggtcc tggactatag cacgctgact 420
ctcccgacgg tcctagtctc cgagttcggc agtacaggcc tgcaggatat catcaaagag 480
gtacagaaca gcattccggg ccttaagttc ctgaaggtcg gcagcagcat tgcggatacg 540
gcaaccaaaa cgctggacgt aacaaaaaaa ctggaaaaag ccaaggacag cgtaaaatcc 600
ctgaacgaga aaacgacctc ctatgattcg gcacacagcg cattcgatga cgcattgaac 660
gagctgaaaa agacgatggg agaaaaaccg ggagaaaatg cgaccgtcga tgagctcgac 720
gcatacaata agcggtatga gcagacactg gagaatgcgc agaaagccaa aaaggaatac 780
gaaaagaagc tgcaggcaga aattaagagt acagagtcgc tgaataagga cctcaaggat 840
gtggcaaaga cgcaggatga agtgctggat ggctgggtaa gcgttggtaa ggatgccgta 900
aatgccgtag gagacgccaa gaacacaaag gtggacacat ccggcgaaga aacaacggtt 960
acgaccctga caggtcagat cgacgcgacc caaaaagaac tggaaaagaa agatattacg 1020
gccgaagaaa aaacgaagct ggaacagcag cttaaacagc tgcagcagca ggaggcggac 1080
ctgaagacga taagcaatgc ggccgatgca acggtgaaag ccgcagacag ctctcaggcc 1140
aataaaatac tgaaggatta taatacggat tcctgcagca cggcaatttc cggcctgaca 1200
gaagaactga accgtgtgaa ggatatggat ctgagtgacc tgacccttga cgatgcagac 1260
aagatcacaa aacttcagga agggcttcat ctgaccgata tgagcaagct gtcggattcg 1320
gacaacttta attcgctgct gaaagaagca aatgatctga tcaataaggc ggattccaat 1380
gttacaagtt tctcgtccat tgcagaagca ctgagcacga tcatgtcttt gagtgcaagc 1440
tacgacccga aactgcaaag cgtgatcaat acggagtact acgatcagaa ttttgcaggc 1500
ctgccgagca agaaggaccg cagcaacagt gcttatacgc tggagtctcc gtatgaacag 1560
aaggatgcgg cattggcaca ggcagatcta gatgccattg attttgtaaa cgagatcatg 1620
gatctgacgg catggcaggg cggcgtttcg actgctgctt cggccgatac gtcgaaggcg 1680
gatgacgcaa aaaccaagat cggaaaactg ctcaattcga tgaagtccat gctcagcatg 1740
gtgacggctg gagccaatat tctttccaat ctgtcaaaca tcaaggcaga tatcggcgat 1800
catctgtatc tggttgggta tttgaactat accacaacga accgcacgga ctatgcctca 1860
aaaaagacaa tgtcgggcgt gagcataaaa ggctcaaatg gcctggcggc agaagtagca 1920
aagagcgaaa ataacctgac cgctattttt gacgcaaagg aggaaacgaa ttattcgttc 1980
tgtggtgccg agacggagta tcttctgatc ggaaatgaac atgaacggga aaatcagaag 2040
gcaatcttct acacgatgct ggccctgcgt gtggcgctgg actacaagcc ggtgacatcc 2100
aatgttgaag caagagcatt gagcgcgggc ctggctggtg cactgtccct gcttggcatt 2160
ccgtacaaaa tgacagatat gctggcaaaa gttttcctgg ttgcagcaga agcatatgtg 2220
gataccgtgc tgatctgtaa cggtgcacag gatattccct ttatcaaggc gtcggaggat 2280
attcattttt gcgcaaaagg cttgtcgaaa cttcccggaa agctgcaaaa actggttgcc 2340
atgacggatg accagaaaaa gacattgcag gaaaaggtga agcaggttga ggcaggcggc 2400
gttatcctgg gcggactgga gtcggacggc aaaggcgttg aagatctgcc caatctgaaa 2460
ggcagcaatg gcctttatgt gggagataac aagctatgca tgacctacag ccgaagtatg 2520
tttgttatga tgctgatctg gaacgaaaag gatctggtca aacgctttgc ggacctgatc 2580
gaaatggaag cgacccagaa gaatttggtc aatgatgcat cggtctctca gaagctgtct 2640
ggcatttacc ccaaatttga tttggataag tcctacacag cactgcgcat gaacgtaaaa 2700
ggcgattttg tgtcggtgct cccggtgcct tcgctctccc ggaattcggt ttggaaagca 2760
aatcgggtca tgtatagggg gtattga 2787
<210> 192
<211> 588
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(588)
<223> ICBIDGAJ_00777
<400> 192
atgcagaaaa aaaagagaaa tctgttttac gcagaagagg gtgtaatggc gctggaagcg 60
tgcatttcat tgacactgtt tctgatcgcc atgatggcac tgtacagttt gatcaatatg 120
tttacggcac agagcatgat ctcacatgca ttgcagcaga cagggcagag cattgcactg 180
gaaaattata aaaattcaaa gacggacgta aaaacactgc aaaagcttcc gctgagtctg 240
ctgcaaaagt tcacagacgg cattggtgct tccagtgact caaagtatga tgtcggcgga 300
gggtccttct caaattcgat ggtttttacc gactatctgt ctttgagcac tgtgaaaaaa 360
aggtttgcat cttatctggg aggaaatacg gaaaacgcgg ataagatgct gcagaatatg 420
ggcgttgtgg atggattgaa cggcatcaag ataaaaagcg gaaagatcag cggaaatgat 480
gtcgtgatcg agatatccta caaagtccgg ctcatatttt acattgaaac gttccacttt 540
ggcgagttcg aaagtacaca aaaagtttgc tgccgcctct ggaagtaa 588
<210> 193
<211> 177
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(177)
<223> ICBIDGAJ_01351
<400> 193
atgagccgcc tgcgggaatt tgccttaaaa atattgctga gaaaggagaa aggcatcatg 60
gcagtcatct atgcaaccct cattgtgaag ggtaagaaga ctctcgatca ggttccggca 120
ttgattcgga agcaggacga ggaaatcctg aaggacctcg aagtcgaggt cgaatga 177
<210> 194
<211> 1479
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1479)
<223> ICBIDGAJ_02512
<400> 194
atggcatcgt ttgaattgcg agaacccaaa aagaagcctc gttattataa actcatcgca 60
aatgttctgg tgaacggcaa aattgaacgc cgttatggtc ggttcgattt tgaccccacc 120
gaactgaaaa acgctcgtgc gcgcaacgcc gctgcgaaag ctgccgctgc cgaatttgaa 180
cggctggaac aggaaaaggc cgataaagaa gccagcaacg ccggaaagac ctttgcagta 240
gtggcgcagg agtacataga atccaaaaag gcaagacttg ctccttctgc tcgcttagag 300
ggcgattatg acagccatcg taataaggcg aacacaacga ggggcaagga aaactacctt 360
cggaagattc agcaattccc tgagtttgca cagaagcccg ttgattccat caaaaaggtg 420
gattgtgatt gggttctgga acaaatcgaa attggcggcg cacggtgccg cacccatgct 480
gttatcaatc agcgtggtct ggagatgaaa aaggaatctt gtccgaagtt agctaaaaga 540
tgcgattgtg gagcaaaaac catcgaaaag gcatttcgca gcgaaacagt tgatattaaa 600
acagcagaac aggtggcgat tgcgctgggc tgtaaagtgg acgatgcttt tgatgtggaa 660
accattgcaa aacctatgac cagaaagagc atgagagaat acgctctgtt cattcgttct 720
acactggaat atgcggatga aaattacggt gtgaagaatc ccatgcacaa aattcctgca 780
ctgggaagcc ggagcaggtc ggtagacact attaagaagc accagatcaa gcagcttcag 840
gacaccttaa aggaaagttc catgttggaa caggtgatcg ttctgtccct gctcaattct 900
ggtgtgcgcc gtggcgaact ggctggactg acatggaaag atgtcaactt tgaagaatgc 960
acgatacata tttctaaatc gcttctggta ttcaaagatt ttgggtatca gttgacaacg 1020
accaaggaaa gcaacatccg ggatgtggac gttgcaccgg agtacatgga cttcctcaaa 1080
gaatattata agtattggaa gtcccagaaa aaattgatgg gagggagttg gcagaaaagt 1140
ctggataaga aaagcagcaa gtatgcaccc tcactccttg cccttcgggg gacggacttc 1200
gtgatctgca atgaccatgg gttccccatc aacccggaca gctatggcgc actggttcgc 1260
agaatcggac agcgggcagg cattgaaggg ctgcatcctc atatgttccg gcacactttt 1320
gtgagcatcc tcttgtccaa cccggagatc ggtgtggcga cagtagccgc agaagccgga 1380
cacgcacagc ccagtaccac ccttgcaatt tacacgcagg tctatgacaa acggcgcaaa 1440
gaaattcgca accagatgag caaggagctg tacgaatga 1479
<210> 195
<211> 309
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(309)
<223> ICBIDGAJ_01352
<400> 195
atggaccagc ctattacgcg agccgagcat gaggagttca agcgtcggct cgaagaggaa 60
aatgcccgtc aggacagacg aatcgccttg ctggaggaaa gcgtaagcaa aatgggcgca 120
ctgtccactt cggtcgagaa gctggccctg agtatggaga gcatggtcag ggagcaggaa 180
aagcagggaa aacggctgga aactctggag agccgcgatg gagagctgtg gcgtaaggcc 240
gtcggctatg cagtaacggc catcatcggc gcttttctcg gctatgtgtt cacccaaatc 300
ggtttttag 309
<210> 196
<211> 339
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(339)
<223> ICBIDGAJ_01357
<400> 196
atgtttgatt tgcgtgagca taaaggcctc attcaccgtt tggtttccga ggcaaacaaa 60
aatgatgcca actggcactg gtcactaaaa gctctcagca agaccaaagc cagcattttc 120
tggagctatc tggagtacga aggccataag ccgtgcttta cgattgaact tgtcgaggac 180
gacgatggct gcttgattta tgcgaaggat gagcacggag acacactcaa ctttgagata 240
gttgagtgtg taggtcttcc tcgcctgaac accccgattg atgaagccat caaaatgatg 300
gcctattcga ttattaacac cgcccatgag tgctactga 339
<210> 197
<211> 153
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(153)
<223> ICBIDGAJ_01356
<400> 197
atgaaaggtg agtgcagtat gacagctctg gaagcctctc gtctgatcga ctggctgaaa 60
gctcacggtc atacggacga ggaagcgacg cagtgtatca agtgcattgc cggagtcctc 120
gacccgcaga ccgaggagcc taagaaacag taa 153
<210> 198
<211> 648
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(648)
<223> ICBIDGAJ_01768
<400> 198
atgcagagtg gatgcagatg ggtatacacc ctgatggact gggaaaccgg cgaggtggtg 60
gccaagggca ccagcgtgga gctggtggag cagggatatt ttcccgatgt gaacaagctg 120
agcagcgttt ggaataatct ggaaaaatgc aagaacccca gcccgaagaa ctaccggtgg 180
aagatggagc ggaagagcac caaggacgac cgggtggaga gggccagggc agaaggcctg 240
agcgcggacg agcgggccga gacccggata gtgcgggtgt acagctgcta cggtgcggac 300
ggcaccctgc tgggcaaggg cacggcggca gagctgaagg acaagggatt gtttggcagc 360
gagggcacag tgcacgagtg ctaccgcaag cggggcggcg tgtacaagcc cggcggcgtt 420
acgcggatgg agatggagct gtgccagaaa cggatccggc accccatgaa gctgccggat 480
cagccggtga aggtgaagcg caagcccatt ggcggcgtgc tcgaccccag ccccctggcc 540
tacgacgtgc atgatctgat gatctacaac gagaaggccc gaaagatcgg aaagccggag 600
ctgacctacg gctactgggc ggaaaaagga aagcccgcca cgccttaa 648
<210> 199
<211> 147
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(147)
<223> ICBIDGAJ_01769
<400> 199
atgactaacg aactgactgt ccggcagaaa tgtgcggatg ccatggcagc ggctaccgga 60
agaaacctct caccgctgcg gtctggctat gccagcgcct tgcagagctc ccctgatatg 120
ggagccaagg atcaaggagg acgataa 147
<210> 200
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> ICBIDGAJ_02457
<400> 200
atggacaaaa acaatataac ctctgtgaaa attcctgcgg gtgccttttg cggacacaac 60
tgttctgacg gatgtatcta ttggaaccct tatgaccgtg atagtaatgg ccgccagtac 120
tgttcgcatt atgatactta ctactatccg agagagcgcc aaggatgtct tagttatgaa 180
gactaa 186
<210> 201
<211> 225
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(225)
<223> ICBIDGAJ_01760
<400> 201
atggatatgg cagaagcaaa gaaaaagact gagacgatcc ggttgttttc ggacggcgga 60
aagtacaagg gtgacctgtt cgtgagcgtg aacggtgtga actaccagct gcagcgcgga 120
aagaacattg aggtgccccc ggaggtggcg gaggtcatcc gccacagcca ggaacaggac 180
gaccagaccg ctgcccgcat ggaagagctg gcgaataagg cgtaa 225
<210> 202
<211> 624
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(624)
<223> ICBIDGAJ_01765
<400> 202
atggccatgc tgggctcaac ctccatctgc gctgtggcga agaagtacgg cgtgccggaa 60
tcgacaatcc gcagctggat gagcgaggag gcaggccgca gtgatgcctt tgcaaaggcc 120
cggcaggaag ccgcgcggga gatcgccatc cgggcaagcc tgggggtgcg ggcacaggtg 180
acctttttgc agggccgggc cgctgagagc cagcgggcgg cgcagatcac ggagaggctg 240
caccggcgtt tggacgagga cacccgggcc cgggactttg ccgtgggcac tctgctgaag 300
gacgacccgg aggagttggc ggatgccacc gagaccggcc ttgtggtgta tgcaagcccg 360
ggcagctacg acaggcagct ggatgacacg gaacgcaggc ggctgaacgc cgaactggag 420
cggtacgagg gccgggtgat gagcgacaag aacgcggccg gtgtggccaa ggtgctgatg 480
gaagtggccg aaaaggctgc tgccatggcc ccggcggaga acaccgacag cgagagcggc 540
ccgccgatgg tggagatcgc ggcagccgga gacgcggacg gcaagcagga ggtggaagtg 600
gatggcggca cagaggatgc gtga 624
<210> 203
<211> 885
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(885)
<223> ICBIDGAJ_01767
<400> 203
atgcgctgta actacatccg agagaaaaaa taccagtgcg gggatgacta catggcagtc 60
ggagtgttct ccatcatccc ccaggaacac cggggccggg gcaagaagcg gaaggaatcc 120
agcgaggggc agaaggcgaa gaacaaaatg gattccctgc gcaagcgcca gagaaaggcg 180
ctgacaaatt tcagtccggc gggaatgttc ctgaccggta catacgagga tccatttctg 240
ccggaggaca ttctggcctg ccggagagac gtggagaact acaagaggcg ggtgatggcg 300
gccacctgca agcggttcgg ggcaaggcgg gaggacatcc gcctgatgct ggtggcggtg 360
cgcaagggag aagcaggacg gctgcacatg cacggttttg cggaatgccc gggcctgacc 420
gcagcccagc gccgggagtg gcgggagatg ctggaggatc tgtggcggcg gcgtatcccc 480
ggctccaacg agtttgagcc gctgggaacc atgaacgtgg atcggatcga catgaaaaag 540
ctgctgggca agagcgggca gggcgaatac ggaacggtgg gctacctcta cggccacaag 600
gagcggctgt gggtggaaac agtcaacctg cgcccggcca ttgagcaggc ccccaacgat 660
ggcagatgga gccggaaaca gctgcgggcc gcctgcgggg aaaagcagaa cgatgcccag 720
tggtgggagc agcggtttcc cggctggaag atggaaaagt gcatcgtgct ggagcccggc 780
gggctgcatg agagcccgaa gcgggaagga accggctggg aacggctgga accgcaatgc 840
tatgtgatcc tgcgtcggcg ggaggctgcg attcttcgca cctga 885
<210> 204
<211> 1416
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1416)
<223> ICBIDGAJ_00754
<400> 204
atgggaaaat accaagaaga cgcaaggctg ctgcttgagt acgttggcgg caaagagaac 60
atcgcggcag tttcgcactg tgtatccagg atgcgttttg tgctgaatga tcccgccaag 120
gcggacgttg tcaagatcga ggcactgaaa tccgccaagg gcactttcac ccaagcgggc 180
cagttccagg tcatcatcgg caatacggtc agcgacttct acaacgactt cattgcggta 240
tccggcattg acggtgtttc caaggatgcc gtcaagagcg cggctaagca gaaccagaac 300
gcattgcaga aggtcatgag cgtgcttgcg gagatttttg ccccgttgat tcccgccatc 360
atcaccggcg gtttgattct cggcttccgc aactgcattg acagcatcta cttttttaat 420
aacggcaccc agacgctgtg caacatcagt cagttctggt ccggcgttga cagcttcctg 480
tggctgattg gcgaagccat cttccatatg ctgccggtct gcatctgctg gtctgtcaca 540
aagaaaatgg gcacgaccca aagcctgggc atcgtcctcg gcctgacgct cgtctctggc 600
cagctgctca acgcttacgc cgtggcttct actgcggcgg cagatatccc gaaatgggat 660
ttcggtttct tcaccgtgaa catgatcggc tatcaggcac aggtgatccc ggcaatcctt 720
gcagccttca cgctggtgta cttggaacgc ttcttccgca agatctgccc gccggtcatc 780
tcgatgatcg tggtgccctt ctgctcgctg gtgctgtccg tcatcatcgc ccacactgtc 840
cttggcccca tcggctggaa gatcggcacc ttcatttctg acatcgtcta cgccggcatt 900
tccggctcct tccgcgtggt ctttggcgca atcttcggtt ttgtttatgc cccgctggtc 960
atcaccggcc tgcatcacat gtccaacgcc atcgatatgc agctgatcgc cgacttcggc 1020
ggtacgatgc tgtggccgat gatcgccctt tccaacattg cacagggctc cgccgtgctg 1080
ggcatgatct acctgcagcg caagaatgct gccgcacagg aagtcaacgt tccctcctgc 1140
atctcctgct atctgggcgt taccgagcct gccatgttcg gtgtcaacct gaaattccac 1200
ttcccgttta tttgcggcat gattggatct gccatcgcag cggtcgtctg tgtggcaact 1260
tccaccacgg ccaacgccat cggtgtcggc ggcatccctg gtattttgtc aatccagccc 1320
gcctatatgc tcagctttgc gctgtgcatg gccattgcca tcgtcgtccc ctttgtgctg 1380
accgtcatcg tcggcaggaa aaaaggcgtt gcctga 1416
<210> 205
<211> 1626
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1626)
<223> ICBIDGAJ_00755
<400> 205
atgaatgatt ttaaagataa agttgtctac caaatttacc cgaaatcctt catggactcg 60
aacggtgacg gcttcggcga tttgaagggc gtcaccgcga aactggacta cctcgccgac 120
ctgggcgttg actatctctg gctgacgccg ttcttcccct cgccccagcg cgacaacggc 180
tatgatgtgg ccgactaccg tgccgttgac ccgcgttacg gcacgatgga ggagctggag 240
gagcttatcc gcgaggcgga caggcgcggc atcggcctga tgctggacat ggtgttcaac 300
cacacctcca ccgagcatga gtggttcaaa aaagcactgg cgggcgacaa aaagtaccag 360
gactattaca tcttcaagga cggcacgccc gactgctgcc cgacgaactg ggtgtcgaaa 420
ttcggcggcc ctgcgtggga atatgtacca tggctcggca agtggtatct gcacctgtac 480
gatgtgatgc aagccgacct gaactgggag aaccccgccg tgcgggagga aatggccgac 540
atcctgcgat tctggaaggc gaagggcatc aagggtttcc gtttcgacgt catcaacgtc 600
atttccaagc ccaaatttta cgagaatgac tacgagggcg acggccgccg cttctacacc 660
gatggccgca acgtccacaa gtacctgaag gagctggtcg ccgcgggcgg catcgacggc 720
atgatcacgg tgggggagat gtcctccacc acgctggaaa actgcatcgg ctacaccgct 780
gagggcaatc acgagctgac gatgtgcttc aatttccacc acctgaaggt cgactacaag 840
gacgggcaaa agtgggaatt gagggagcct gattacctcg ccatgaagaa actgttccag 900
acctggcagg aggggatgca ggcccacggc ggctggaatg cgctgttctg gtgcaaccac 960
gaccagcccc gtgcggtcag ccgctttggc agcgacacga cctactggga ggaaagcgcc 1020
gagatgctgg cggtggccat ccactttatg cgcggcacac cgtacattta tcagggtgag 1080
gagctgggca tgacgaaccc gcacttcacg aaaatcgagc agtaccgcga catcgagagc 1140
cgcaactact acaggatcct gcgagagcag gacaagacag aggccgagac gctggacatt 1200
atcgcccagc gcagccgcga cgacagccgc accccgatgc agtgggacgc gagcgagaac 1260
gccggtttta ccaccggtac gccgtggatc ggcattgccg acaactacaa ggccatcaac 1320
gccgctgccc aaatggacgc cccggattcc atccgcagct tttacaaaac gctggtggcc 1380
ctgcgcaaga aaatgccggt catcagtgcg ggaaaaatcg agttcttgta ccccgacaac 1440
gcggatttgt tagcctatcg ccggtacgac ggcgagacgg agctgctggt tctctgcaac 1500
ctgcgggagc gggaaattgc caagcccctg cccgtaggct ggaccgatgc cgagaaactg 1560
ctgggtaact accccgacac cgccgacacg ctgcgcccct atgagtgcgt agtgctgaaa 1620
aagtga 1626
<210> 206
<211> 723
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(723)
<223> ICBIDGAJ_00753
<400> 206
atgccaaaag caaaatatga aggaatttac cgcagtatca aaaaacggat cgaagcgcag 60
gactatcctt accagtccct gcttcccagt gaaaatacgc tgattgcaga atacgactgc 120
tcccgcaaca cggtgcgccg tgcaattgcg gaactgatcg ccgacggcta tgtgcagtcc 180
atgcagggac ggggcgttcg ggtcatctac cagccggtgg gaaagacgac ctttaccatc 240
ggtggaatcg agacgtttca agaaaccgcc cgccgcaatc gtctgcaagc cgttacccgc 300
gtcattcggt ttgagaccat catcgcaacg gagcagtttg ccgaggaaag cggattttct 360
gagggcgatg aattgtgggc ggtacagcgt gtgcgttatc tggacggaaa agcactgatt 420
ctggacatca actacttttt aaaggaattt gtacccggac tgacagagga aatcgcatcc 480
cattccatct atgattttat tgaaaacgtg cttggaatgc agatcatcac cagcaaacgg 540
cgcatcacgg tggaacacgc aactgcccgt gatgaaaagc tgctggatat ggacggctat 600
gattgcgtgg ccgtcgtcgt gaaccagact ttcaactcgg acgggatgct gttcgagtac 660
acccagtccc gccaccaacc ggactatttc tcctttcagg acattgccac gcggaaaaag 720
tga 723
<210> 207
<211> 921
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(921)
<223> ICBIDGAJ_01856
<400> 207
atggaagaaa taactgtatt gatgtcaact tataacggcg aaaaatatct acgggaacag 60
ttggacagta tttttttgca aaaaaatgta aaattgaagc tactcgttag agatgatggc 120
tcaacagata acacaatgca gattctgcaa gagtatcgac agaaatattc tgatttggaa 180
atttggacgg atggaaaaaa tcttaagcca tgcaagtctt ttttctatct aattcagaat 240
gcaccagaaa cggaatatta tgctttggca gatcaagatg atatttggga ttgcgataaa 300
ttggaaacag caattgatcg actgaaaaga tactcgcaag agatcccggc actctactat 360
agcaacctta gaattgtaga tgaaaaggat gtcttttatc gaaattcgca tgaaatgcct 420
gcaatatgta gaaataaata cgaatatctc acagacatga aggctacggg ctgtacaatt 480
gtctacaata gagcattggc agaattaata cataacagaa tcccggatga attcaccatg 540
cacgatgcat ttctttatat tattgcgtca atattcggaa atgtgattta tgactttgaa 600
ccgcatatag attatcgtca gcatggagac aattccattg gtacatacct tgacaagaag 660
cctgttacag catatttcaa gcatatgggg agactccttg acagaaatcg gcaaccaaga 720
cgaaaaaatg ctgatgcagt attgtcgaag tatggtgaat tcctgcaaaa tacacatccg 780
agagagtatg aaaaattaat ggaactttcg acctataaaa atagcttgaa acaaacagta 840
caactactga aggataagga actttatcca tcttctggaa tgtttcgcta cagcgtgtta 900
gcaattttgg gactgctgta a 921
<210> 208
<211> 567
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(567)
<223> BLCPAMOF_00067
<400> 208
atggattcca agggcgaagc aattaccgtt aatatttttg atgctataaa ggaattctac 60
ggcttgacac ttgttgatct tgcagttctt tttagggaaa actttggcgt gatgtattat 120
gcgcgtaatg tgcgtattac ggacaggcgt gcatatcagt ttgcaagtac acttcgtctt 180
ccagtggaat tgttcaaaaa tacaactaca gatgattttg atcaaattga atttggcaag 240
aaactctttc ttaaaaataa tgacatagaa gaaatccgta atgcaatgcc ggattggaaa 300
gcacgattgg caaaaatgtt ggcacagctc tatttgagat gcccgatgga cacggcaaaa 360
gaactatcca gaatggatcg cttttattgg agcaggggcg ataatatgga tcggctgaat 420
gcaaccgaac ggctgtttgt ttctacagcg gaaaaacgga ttagaaatga gtcgcattca 480
attctattgg gagtaagtta ttttttggat aacaaaacgg catcacattt taatctacga 540
caaagtcgta gtggaagata tgattga 567
<210> 209
<211> 438
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(438)
<223> BLCPAMOF_00066
<400> 209
atgaaaattc taggagtgct tcttgcgttt gtcggttttg cgcttggaat atatgaaata 60
atcaatacgc ttagaggaaa agaaaataaa aggatattgt gtggcgtagc gatagcatat 120
cttggctacg gtgtgtgcta ttcagtgtct caaaaagatt tggggtatct tggtgttgca 180
tttttatttg ggttgatttt ttatgcaata agagttatgt gcgttctctt gaggatggct 240
gctaagcgtg aaaaacgcag tcttaagaat gatttgatag tgctggctgt tctgttggta 300
ggttttattg ccggaatgat gcttccatat gataaggaag aagaagctaa aagaactgca 360
gaatcagtcg ctagtgtgat ggaaaaagcg gcacttccgc ttgcaggcct tgattataca 420
ctggatgatg tgaattga 438
<210> 210
<211> 444
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(444)
<223> BLCPAMOF_00069
<400> 210
atggacaaca accaactaca gtacatcaaa attcaatcgc aatacgctga taaggtagaa 60
caatttgaaa agtgcgttgt caaagccgca aagctgacac acgcgattgc tgacacggct 120
gagaaaaaat gcaagcaggc gcggatggca atggaatctg gcaacataga tgtcatgcgg 180
aatacgattc agcagtacat ctgccagtac ggacgggatt ggtcacgttt ccgggatgtt 240
cggatacagc ttgtagatgg gaacacctat gcacagctct ctgccgttga tcttatccag 300
cagctacatt gtgttatcac gctggtgtac aaggatactg cgttgaaaac ggtgaacaaa 360
gaagtattcc gagagtgcgt taaaagtttg ctgaagcagt ccaaaatgtt taccgataaa 420
gagctagatg caatgtttgc gtaa 444
<210> 211
<211> 612
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(612)
<223> BLCPAMOF_01414
<400> 211
atgatgacgt ccgagcagat acagcagctt cggcgcgatg agactgcgat gatggcagaa 60
tggtcggcgt cctctgtgca gccgtgccgc tttaacaccg acggcatcgt ggactatgag 120
cgctgggcgg cactcccggg cggaaagcat atcgttgttc tattgaagga aacgaatgct 180
ctgagcggaa gccttgtgga ttttctttct catggcggaa gcaaaactta ctaccggacg 240
tggaataatg tcgcacgctg gataaatatg gttttgaatg gaacatattg ggaattcgtg 300
ccaaaatcag ctctggatga tatggttagg aatatcgctg tgataaacct caaaaagtgt 360
tccggcagcg cccatgcaag cacaaaggcg gtacggcagg ccgcccggca ggatgcggac 420
cgactgaaac gtcagataca gctctacgaa ccggacatca tcctgaccgg cggctggggg 480
ctggtatcga acattctgca cgatgagata cttgcggatg acgccgagtg ggtcaagccc 540
aatggacaga cagcattatg gtattacacg agctgttcag tccgttcgga aaaagaaaca 600
ctctcgttgt ga 612
<210> 212
<211> 861
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(861)
<223> BLCPAMOF_00555
<400> 212
atgaagacct cttataatga agcctgcgcc cgcgactgct ctactctgga aaaagatctc 60
gccctctgcg agaaagctgg cttcgattac atcgaaatac gacttgatct gctccgaggc 120
tggctcaagg accacacggt agagcagctc aaggaatttt tcgaaacgca tcggctcaag 180
ccccacgcca ctaacgccgt ctacctgcat catgggatgc tgccggacga aacgcccgac 240
tgggatgacc ccgccatgca ggacttcaag ctggcctgtg aggtgggcag cgccatcggc 300
agcggctacg tcatcatcgt gccgcccctc gaccccagcg gggtgttcac cggtgatgta 360
gccgccgcag agcaggagtg catccgcatc ctgaaaaaac tctcggcgct ggcccggccc 420
tacggcatga agctctgctt cgagctggtt ggcctgcgca agagctgtgt gcgcagcatc 480
gaggccgccg accgcatcgt gcgggccgtg ggcgaggaca acgcaggctt cgtgttcgac 540
tcctacaaca tctacctcaa cggccgctgc aacgatttca gcgccatcaa aaacgtgcag 600
cccgaaaaaa tctttgccat ccacctgatg agcgccgacg acgtccccga aagcgagatg 660
gggcaggaca agcgctgctt tgccggcacc ggcgccgtga acaccgacag ctttttgcag 720
accctgaaat gctgcggcta cgacggcatg gtctcggtgg agaccttccg ccccgaatac 780
tgggccaaga cccctgagtg ggtcattgag aatgcctatc gtacgaccta tgccgcactg 840
gaaaagaacc agtgcctcta a 861
<210> 213
<211> 132
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(132)
<223> BLCPAMOF_01552
<400> 213
atgagcaaca aggaaaaact gaccgagcgc tgggcgcagg ggcgtatctc tgaggcaatg 60
ctgcgggtgt atgtccgcaa gggcatcatc accaaggcgg atttcgagga gatctgcggg 120
aagaagtatt ga 132
<210> 214
<211> 369
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(369)
<223> BLCPAMOF_01553
<400> 214
atggcacgat acaaaattta cgacaacaaa tctgacgtca tcaccccggt gggcgagaag 60
cttaccgctg agcagtggct ggaccgttac cagtggggcc gctacaccaa gatgatcgtg 120
ggcggcggca tcatcaacgg cagcgtcgcg ctggtcttcg acgatgaggt ggagcgttac 180
cgcaaggcag gctgcgattt cagtgcctgc accaccgacg aggactatct ggccgccatc 240
gaggcctttg aggataaccc gcccgtggca gacgccggcg tctccgacca gacccgcatt 300
gcggacgctc tggaagacat ggtggcgctg agcctgccgg atgataccac caacaccacc 360
gaggaatga 369
<210> 215
<211> 1125
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1125)
<223> BLCPAMOF_01554
<400> 215
atggcaaaag cagtttatgt gggagtcgga agcaaagccc acaagatgaa gaaagcctac 60
atcggcatcg gcggtaaggc ccgcaaggtt aagaagatgt acatcggtgt cggaggcaag 120
gcgaggctgt gctacagtgc agagctggaa aaggtcggga tggctacggc gctgagcact 180
acacggtatg atatgcgggc cgcgaccgtc ggcaaatacg ctttgtttgc gggtggatat 240
atctccaagt cctcttttgg ctacagcgtc agcagttccg tggatgccta caatacctcc 300
cttacgaaga gcacaccgac agagctgagc tacaaacggt gcggtcatgc ggcggcatct 360
gtcggcggct atgcgctgtt tgctggcggc gcatcgtcat ataatctatt gggcttttat 420
gaaaatctcg tgagcgctgt ggatgcatac gatgcctctc tgacccgcag tgccgcccac 480
ataataggcg ccacagtcgc gatcggaggt gcagccgtcg gaaactacgc gctgttcgca 540
ggtgggacgg tctacagtca aataaatgaa gataacgtga cgagcgatgt gctggcgtac 600
gatccctcac tcaccttcac gacagcacct tggttgagtg ttgcacgagc gaatgtgaaa 660
ggcgcaagcg caggcaatta cgcactgttc gctggcggaa gagccggtag tttttgtacg 720
acagtggacg cctacaatgc ttcgctcacc cgcaccaccg cgaccgctct gagcagcacg 780
aaaaacaaca gcgccgctgc aactgtcggg aaccacgcaa tatttgtggg caacactgcc 840
tccgcagaca tctacgatgc ctccctcacc aaaacgtctg ccgccatcct gagcacggcg 900
cggacgggtc tggctgcgac gacggtcgga gactacgcca tcttttcagg aggtggagtg 960
gcagatttct gcgacgcctc tctgacccgg agcagcatcg gcaccagcat gacgggctat 1020
gacatgggtg ctgcgaccat cggggactac gctttgtttg caggcgggca atccggtgaa 1080
aacagtggca ccgcttacga ttccgtcgaa gtctacaccg cataa 1125
<210> 216
<211> 729
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(729)
<223> BLCPAMOF_01093
<400> 216
atgataccta caagaaagac cgatgaaaaa ttttatcggc tgttttcgac ctttcacgcc 60
ttttcagagc atctgaccaa gcgggaagac aatgaactgc gcgataaata cgaccacaat 120
gcgttctgtt attccggcca gcccacggag gacgagctcc gggccgcgct ggcttatcag 180
aaagcgcggg gagacgcctt cctcaaactg gaaggatacg agccgctggc caatgcattc 240
ggcatggagt gcgaggagac tgtgacgatg gttctgccga agggaacaga catcagcggc 300
tggaaagcga atccggaggt ctcgatcaaa accccggact ttgaccaact agaacagcac 360
gagctgaaat actacgggcc gttgtacgga gaagatttca ccgtgcggaa caaccggcat 420
ctccgggaaa aactgaccta ccttggagcg tatctgggcg ggaaactggc gggcgactgc 480
tatattttcg catccgatgg atacgtctgc atggacagtc ttttggtgga tgaagctttc 540
cgtcatcaat acatcgccac gaccctggtg aagcacattg ccgaaaaggc acaggaacgc 600
ggggctgttc tgtatcttca tgccgacccc gaggacaccc cgaaggatat gtatgcaaag 660
atgggatttc aggctgtcga taagctctat gaatatctct gcacagattt ttcaaaggtg 720
aaaatataa 729
<210> 217
<211> 213
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(213)
<223> BLCPAMOF_00662
<400> 217
atgaaaaaaa caaaacagaa atggtgcctg cgcatcctgg tctggctggt ggctctgctg 60
gtccttctgg gggtggcaga ctcctgtcgt gttcaggaag accctcaccg cacactggta 120
cagggcagac tgcaggaact gaacgacagc tggacgctgg aaacagatca gcaggccgtg 180
tatgacattc cggaaagcat ggggaaagcc tga 213
<210> 218
<211> 1425
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1425)
<223> BLCPAMOF_01558
<400> 218
atgaagtgcc tgtttgtgac gctcatgtgg aatgcccggg ccgaaatgcc cgtgccgggc 60
gatatttttg cggtctgctg tcagtcttac agcccgaatg gaatgacgcg gtacagacgc 120
tacacccatc tggacgacat gagcgccctg acgcagtgga caaaagatgc tgtttaccac 180
aacatcacgg tactggaaac agcaaagccg cgaaaagaga ttttgaatac ggtagcggag 240
accttcccgg cctatgacgt tctggtcctg tggagccgga aagaatatga gctgttccgg 300
caggcgatgt atgactgcgg acatcgcctc tgtacggcga aagccgttct gctggaagaa 360
ctgctgggag cagtcgtccg ccccggaaag aggggccggg tgccttttca gcaggtgctg 420
agggcgtttc atgtccagac gacccgggag acgttttacc agccgaaata ccgggcgggc 480
tttctgcttg agctgtggga cagggtgagc cagcttgcgg cgcagagcga ggagtggacg 540
cagacagaac tctgccttaa ccccaggaca aacaccgtcc acctgccggg atgcagtcat 600
ctcggcctga cgggcggaca gccctgtacg ccgcaggtgc ttctggaagg ggctgccctc 660
tgcagagact gccaaaagaa gaaggcgctt tatctctggg agatggagcg gctgcacgca 720
gtgaagttcc agcctcacgc aggtgctctg gggacgccgc aggattatcc gccggcaccg 780
aagctgttct accgggaggg cgacccgcaa aagctttacc atgaccgtgc ctgcccctgc 840
tgcaaaccgt tccgggaggg gccggactat ctgcagtgga agccgctttt cgggagagcc 900
gatgcggaag ccctcggcct gacggcctgc gaccggtgtt caccgctggg catccggtat 960
gggcagaccc ggacgcagat agagtccttc tgcagccaga gagggatgca gtgtgtgctg 1020
cgggatggcg agatcgacgt cacaacgtcc atcggcgggt ggcggctcgt ctggaaggga 1080
aaagataaga tctggctcta tcacaagaac acccatagga gccatctgac tgagagtgag 1140
gacatccccg gctatcacag tcaggccatt cacaagaaga ccatcatgga gtatttggaa 1200
tacatcgtcc agcacgatct ctaccggaaa aacagtccgc tcccggagac ggggagtgtc 1260
cctgccgcaa aaccgccgga gccgacccat cggggacacg gccatcaccg ggacgcaaag 1320
ggggcaaagc atttccaaaa gcacaagacg aacaaggtga aggtgagctc actggaacaa 1380
ctgcaggcgc tggcccggca gaaaatgacc ggagaagagg aataa 1425
<210> 219
<211> 132
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(132)
<223> BLCPAMOF_01622
<400> 219
atgaaaaaat ttttgatggt actgttgagc attgcatttg tgatgaatcc tgtagaatcg 60
aatcccgcta gattccggct gcggagtcca acgggattct ttttgcccca aacgaaagat 120
aaggctcact ga 132
<210> 220
<211> 150
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(150)
<223> BLCPAMOF_01623
<400> 220
atgacagaaa acttgtgccg gaaaagtatt aaaaatgccg tagaggtaaa agagtatcaa 60
attctctatc atttgagaga gttgcgtcag caaatcggca acgctaaaat gacgaacggc 120
atttttgata cagaaagaaa agagttatga 150
<210> 221
<211> 111
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(111)
<223> BLCPAMOF_01620
<400> 221
atgaatgata tttacgcata cgaccccgat acagaggaag aagcgggcca atgcatggat 60
gaagtgattc agattgcaga ggaaagcggc gccgaaattc agttctacta a 111
<210> 222
<211> 1413
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1413)
<223> BLCPAMOF_01018
<400> 222
atgaaaaaga agtaccaaat atttatttca tccacgtata aggacttagt gaaagctcgt 60
gcaaaggttc gtgatgccat tctgtctatg atgcactttc ctgtgggaat ggaaatgttt 120
aatgctgccg atgaagagca atgggagata attaaggaaa ctattgatag ttcggactat 180
tatgtattga ttttagggca gagatacgga tctgagattg aagaaggctc agatgcagga 240
atcagttata cagaaaaaga attcaggtat gcgactgaaa agaagattcc gattctagtc 300
tttattatgg ctgatagtgt tccgttgcaa cgagacttca tagaatcgga tagtcaacgg 360
aaaaagttgg aaaaattcaa agtaatcgca agtcacggtc atacgatgca gtggtgggag 420
aatgaagatg agttggcgag aaaagtaata gcatcgttgc atcaacagat ggataggaaa 480
gaacgaaccg gatggattcg aggcgacagt tttgatattg aggcaagcta cgcagagtta 540
ttaaaattga acaagaaaat ctgtgagtta gaagaagaaa acgaaaaact caagtcacag 600
attgtcgtaa gaaagccaca tttgaaagtt tcttttgtaa tggcagaagt agactcagca 660
gaagagagca agaaggagga gtgttatttg cacggaggcc tggtgcaaga aataagtgag 720
aatcatataa agatgcggga aattactggc aatgcggaaa attatagaaa taaatacgag 780
ccactggaaa taggttatgt ggatgcgcat ttgaggccgt atgttaggaa agaagatata 840
caaaagtata acgagtcact acctgatgcc aaagcgatag atgaatatat taaacaaatg 900
agggtgtatg agaaactaaa aaagggcggg gttgcacttt atttgaaaat agaaaatgat 960
ggtacggcca aggcaacgga cgttagagtt agtgcaacat ttccagagtg tgttcatttg 1020
atgaatattg atgatgtgaa aaaattagtt gaaccaccag caccgaagct tcccccaaac 1080
ccgattgatg cggcagaaaa aaaatatgaa agaaagatga atcccatggt ggatttggcc 1140
aattattttg catgtgtgca gccaagctat tcatttgatg cgataaattc ctcgtttctt 1200
agcaataggc tagacacaaa agattactgt ttctatattg atgaaaacag tatattcgca 1260
gaaaatagac aactccccca caaagatgca ggaatttttg acgattttta tatgatccct 1320
gtaaagaaag gtgatgctaa aattaaaata tctatgatgt gttcggaata tgttgaacca 1380
gaagagcaat atatcgacat tcaaattgtg tga 1413
<210> 223
<211> 849
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(849)
<223> BLCPAMOF_01014
<400> 223
atgattacgg gatattttta tggagatact gttgcacggc ataaggaagg gcgacagatc 60
aagaaaatac tctacatggt tgtagaggca aatatacttt actttgtctg gaatattgca 120
attgaggttc ttagaagaaa tagcataata tcttatgtgc aatcaatttt ttctataaaa 180
aacttactga aatttttgct ccttaatgat tcaccgttgg catggcatct ttggtattta 240
agcgcagtct tttatgtgct tgtaattgtt ttactggtgg ataaactcaa ctgccggaaa 300
gatttgtact atttgacccc gattttgatt atcgtagatt tggtgttcgg aaagtattca 360
ctgctcattt tccatcggga gttcccgtac atactggtaa gaaatttcct ttgtgtagga 420
ataccgtatt tttgtattgg aaatcttatc agagaaaaac agtgcgctga aaaatggaat 480
aaaacagtac ttcagttatt gattgttatt tttgtgataa caagtcttgc agagagattt 540
gctttggtga atgctggact gaatgcaaca agagatcatt atctcagtac gacttttttg 600
gcaatctgcc tctttgtata caccctcaag agtaattggc ataataaaga attagctgtg 660
attggaagaa aatattctac atggctttat attattcatc cgatttttat tgcatttttt 720
tcaatggtaa ctggtaaact cggcataaaa tcaatttaca gttatgttgc accgattgtg 780
gtttattgtg caacattaat atttttgatt gttatgcata gacttaaatg gcttttagta 840
aaaaaataa 849
<210> 224
<211> 1653
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1653)
<223> BLCPAMOF_00304
<400> 224
atgcggaatc gactggaacg gaggcggctg acactgcgcg ccgcagcact gtgcatcgtg 60
ctggtgctgc tgtgcggctg tctgctgccc gcatttgccg aagggccgga gcggacggac 120
agcatgccgg accagacatg ggacgaggaa atagaggacg agcctgcctg ggacgaagaa 180
gaggacatcc ggacagacga gccggtgctc ctgcccgcag aaggcggcat ccccgccgtg 240
gtggacgggc tggatgacat cgggctgccc gacgagacgc cgactccgga cagcgggact 300
gtcaaagcgg acgagcattt tgagatgaca tacctcttct ggctcagcga gtcggatgag 360
gccgacggcg gcctgcccta cgcggaacag accgtgggca gcggcgaaga gcttctgatg 420
cccgaagagc cggaggtgga gggaaagagc ttccgcttct ggtacagccg ggacgacgaa 480
gggacggcgg tccgcttcgt gccggatgaa ggactgctct ggccggaagc ggacagcgag 540
tgcagcctct acgcctgttt catcgacgat gaggcccagc aggaggagcc tgtttcagac 600
gaggaagaag gcattgccgt tctgccggag ctgtcggaag aacggcccgt tgccgaggag 660
gaaacgtctc tggatgaggc agagcagccc gaagaagaca gatcccctga ggaagatgcc 720
gacttggccg acgacaacgt agccgaggat aaaaccgccc ttcccgcgga cgaacttgat 780
gaggatgcac cgggctgggg ggatcggact caggaagagt cggcggcggt cttcctgctc 840
aagaccccca ccagcctgcc cggcagcaat gaccccagcc agtgggcgcc ggacaacagc 900
gagtgcaagt gggtcggtaa ggtgaagacc tacggcgcgg catgggaaga taacggcaag 960
aacatcctga cagatgtgtc agactatgtt gtatcgtggc cgggcggcgc gactggcgac 1020
gcatggtcgc tgaaaccggg cgatgactac tgggacgagg tcgtcgatga gatatgggac 1080
gagtataagg acaccatcga gaagcagacc ggcatcacgg ggctgacgca ggacgatctg 1140
gagagcatcg ttgtgacgcc gtacaagatc tcgcgcaaga acgggacaaa accggataag 1200
cacatcgact gcatcatcag cgtcaaaagc aggaaaaact tcacggcccg gttcaacgtc 1260
cgcgccccgg gcgaggacga ctacagcatc cgggaaagcc gcgagtacca gagcggcgag 1320
cgggtggaag ggacgacggc ggacatcgaa aaagagctcg acatcggcgg tgcgcgctat 1380
gtctttgacg gctggtacaa agagctcccc ggttcggtga cggatgagcc ggacccgaag 1440
gaaaaggtat cgcaggacga gtgggaagag ggctatgagc ccaccgacga agagctggaa 1500
aacggcgtcg tcaatttcta tgcccactac gttctggccg atatagaccc ggacaccggc 1560
gtggagacag acttcttcgg gctgccgctg gtgctgtgtg ccggtgcggc cgttctgggc 1620
tgcaaaaaca gaaagaagga ggaagatgag tga 1653
<210> 225
<211> 699
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(699)
<223> BLCPAMOF_01951
<400> 225
atgtccatgc tcattgaagt atggggcgac tatgcctgtt tcactcgtcc ggaaatgaag 60
accgagcgtg tgagctacga catgatcact ccatccgctg cgcggggcct tgtggaagcc 120
atctactggc accccgggct gcgttatacg gttgaccgca tctatctgct caagcccttc 180
ggccttgacc ccgaggatga agcgtccacc gaggaataca cccagcggcc catccggttc 240
accaacatcc ggcgcaacga ggtcaagtcc accctgctgt cctccgccgc cctcagtgcg 300
gccaaaggcg gcacaccgcc ggtgctctac acctcggagg acatccagca gcgggccgcg 360
atggtcctgc aggacgtcca ctacgtcatc gagtgtcact ttgatttgac ggacaaggct 420
gcccccagcg acaatcccgg caagttccag gacatcctgc gccgacgcct gcgcaaaggt 480
cagtgctatc accagccctg tttcgggtgc cgggagttcc cggccaactt ccgggagtgg 540
ccgggcggca gcattccggc gctgaaggtc acgcaggacc tcggcttcat gctccacagc 600
ctcgattact ctgattcggc caacatccgc agccagttct tccgcgcaaa gctggtggac 660
ggcgtgatgg aatgccggga cgtggaggtg tttacatga 699
<210> 226
<211> 1764
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1764)
<223> BLCPAMOF_01952
<400> 226
atgatactcc aagcactcac cgcctattat gaacagctct tgaagcaggg caaggtggag 60
gcccccggct gggatagtaa gttcaaagtc agctatgaac tgcgcctcgg ccccgacggc 120
cagctcctcg ccctcaacga cctgcggcag gaagtcccca agggcaaaaa gaccgtcatc 180
tccccccgtg agctccctgt cccccaccgg gtcaagcgtg cctccggcgt cgccgcaaac 240
tttttgtgcg acaatacgtc ctatctgctg ggcgcagatg aaaagggcaa gcccgagcgc 300
tcccgccagt gcttcgaagc ctgtgccgcc cttcaccaca aggttctcga cggcgtggat 360
tcccctgccg ccaaagccat cctcgccttt tttgacagct gggagccgga tacagccccc 420
acccacccgc tgctggcaga gcagtgggcc gacctgaaca acaacgcgaa ccttgtgttc 480
ggctacgaat cccccgacgg cgcccactgg ctggccacca cagatgacgc catccgggcc 540
gcatggcagt ccgcctttga cacctccgat gccgacgccg agacggcccg ctgcctcatc 600
accggcaaag aggccggcat cgcccgcatc caccccgcca tcaagggtgt gatgggcgca 660
caggccgccg gtgcggcgct ggtctccttc aacgcacccg ctttctgctc ctatggccat 720
gaacagggtg ccaacgcccc cgtcagcgag tacgcggcct tcgcctacac cacggccctc 780
aatctgctgc tggcagaccg gaactgctgt cagcgcatcg gcgacaccac catcgtctgc 840
tgggccgaaa acgccgctcc cgcctactca aacgccatgc tgatgttttt ctgcggcggt 900
gccgaggcgc gcggcgtctc ggaaagcgac cttgccgccg cactgaaagc cctttctcaa 960
ggacgccctg tctccttcct cgatgacaag ctggacccga accagaactt ctatgtgctg 1020
ggcatctcac ccaacgcggc ccggctctcc gtccgtttct tcctgcgcaa cagcttcgga 1080
cagtttgcca aaaatctgca ggaccacgcc gaccggctca gcatcacccg ccccgccttc 1140
gacaagcggg aaagcctgtc ggtctgggcg ctggcgcagg agacggtcaa ccagagatcc 1200
cgggacaaaa atccatcgcc tcagctggtg ggcgatctgc tccgggccat cctcaccggc 1260
gggccgtacc ccgccactct gctcaacggc gtgaccctcc gcatccgggc cgaacgggaa 1320
gtcacccgag gccgcgccgc catcctgaaa gcctactatc tccgcaacta ccccaccgag 1380
ctcaacaagg aggtatttac cgtgagcctg aacgaaagca gcaatgtccc ctatgttctg 1440
gggcgtctct tctctgtgct ggagacgatc cagagcgtcg ccaaccccgg catcaacacc 1500
accatcaaag accggtactt caactcggcc tgtgccaccc cggcaacggc cttccctacg 1560
ctggtcaagc tggctcagaa gcatctgcag aagatgagca cccccaacga ggtgcatttc 1620
agcaaacagc tcaccgagct gatggcccag ctgcccgaga caggcttccc ggcgcggctc 1680
agcctgccgg agcagggtgc ctttgagata ggctactacc accagaccca gaaacgctac 1740
gccaaaaaga atgaggagga ataa 1764
<210> 227
<211> 141
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(141)
<223> BLCPAMOF_01796
<400> 227
atggtatatt ctatccagag agatgaaggt gctcaggcac tggaaaatca cttgaatgta 60
attgactcaa aaaagagttt gcgaatagaa tatttagcaa agcagttgaa aagctgtgac 120
gcaaagctaa agggcctgta a 141
<210> 228
<211> 444
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(444)
<223> BLCPAMOF_00719
<400> 228
atgatcggtt tggtagttac cggccacggc cattttgcag acggtatcca cacctctgcg 60
cagatgatcg cgggcgaaaa tgattatgtc cgctacatca actttgaaga ggggatgact 120
cccgagcagc tggccgagaa gttcaacgcc gcttttgacg agttcaagag ctgcgacggc 180
gtcgtggtgc tgtccgacct gcccggcggc tctcccttca agactgctgt ggagtgcaag 240
tatgcacgcc cggagcagaa gatcgaagtc atcgcaggca ccaacctgcc catgatcgtc 300
accgccgtga ccatgctgga catggaggac gatccccgct cgctggcaga cgagcttatc 360
gacaccggca gggactgcat cgctctgttt gagctggagg ctgccactgc cgagaccgaa 420
tctgaagaaa gcgacgggat ctga 444
<210> 229
<211> 1179
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1179)
<223> BLCPAMOF_00718
<400> 229
atgagcattt ttaatctgac cgatgagaag atgaaggaga cgtcttccac ctttacggcc 60
catgagatct atcagcagcc tgccacctgg cgcaagacct gcgcacagct cgctgcctgc 120
aaggatgagc ttcaggcttt tatcgatcag gtcgtcaagc aggatgattt cgacatcgtc 180
ctcaccggtg ccggcaccag cgagttcgtc ggcaactccc tgttccaggc cctgaacccc 240
aagtacgatt tcaaggtcaa gtcctacgct tctaccgacc tcgtgccttc tcccgagaac 300
ttcctctccc gcaccaagcc caccctgctg gtgaactttg gccgttcggg caactccccc 360
gagtctctgg gcaatgtgga ggccgctgag gtcgtctgcc agaacctgta tcatctgttt 420
gtgacctgca accacgaggg caccctgtcc aagctggcaa acacccgtca caactgcttc 480
gccatcaacc tgacccccga gacccacgac cagtccttcg ccatgacttc cagctacagc 540
aatatgtatc tggctaccta tctggccttc aacctcgaca agctggacga gatcaccgct 600
gaggtggaga agctggccgt cgccggtcag cacttcctcg atgaccagtt cggtctggca 660
cagaagatcg tggacgagtt cgattacaac cgcatcgtct atctgggcaa catcggcctg 720
aagggcgtcg ctcaggagtc cgcactgaag accctcgagc tgactgccgg caaggtggcc 780
actatgtacg actctgagct gggcttccgc cacggcccca agtccatcat cgacgacaac 840
accctgaccg tcgcttacct gagcgatgac gagtaccgcc gccgctacga gctggatctg 900
gtcaaggaga tggcacacca gcgcaagggc aacaagatcg ccgtcgtcta caaccacgac 960
tgcgagggca ttgaggagct ggccgactat cccgtccaga tcaaggttgg tgccgacatg 1020
gagaacgtcc tgctgggtct ggacttcatc ctgttcgcac agaccatcgc tctgatgaag 1080
tccctgtctc tgggcatcac cccggataac ccctgcccca ccggcgaggt gaaccgcgtg 1140
gtcaagggcg tcaccctgta cccctacacg ctgaaataa 1179
<210> 230
<211> 132
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(132)
<223> BLCPAMOF_01426
<400> 230
atgagcaaca aggaaaaact gaccgagcgc tggacgcagg gccgtatctc tgaggcgatg 60
ctgcgggtgt atgtccgcaa gggcattatc tcgaaggcgg atttcgagga gatctgcggg 120
aagaagtatt aa 132
<210> 231
<211> 321
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(321)
<223> BLCPAMOF_01427
<400> 231
gtgggcgaga agcttaccgc tgagcagtgg ctggaccgtt accagtgggg ccgctacacc 60
aagatgatcg tgggcggcgg catcatcaac ggcagcgtcg cactggtctt cgacgatgag 120
gtggagcgtt accgcaaggc gggctgcgat ttcagcagct gcaccactga cgaggactat 180
ctggccgcca tcgaggcgtt ccaggataac cctcccatgg cagacgccgg agtctccgac 240
cagacccgca ttgcggacgc tctggaagac atggtggcgc tgagcctgcc ggatgatacc 300
accaacacca ccgaagaata a 321
<210> 232
<211> 624
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(624)
<223> BLCPAMOF_01869
<400> 232
atgataccaa tttctgatat tctcatccgc tcaattagtg ggtatgtgtt tatggttcca 60
gtcttcgtac tgtatttctt gtggctcaaa aaattgggga gaacacaaag ttttctccat 120
accgctgcag tgtttgtttt tggttattat ttattcggac ttttgaccgt cacaggcatc 180
ggctttacaa gcacaatgac ctttcgcccg aacatttctt ggactccatt tatcggtatg 240
ataactgggc caattgatac cattctgaat attattctgt ttgtcccgtt gggatttttc 300
ctgccgctgc tgtacaagaa atatcatcac atgaagacgg ttgcattgac tggctttctg 360
ttttctttgg ctgttgaaat tgtccagatg tttggctggg gttcttccga catcaatgac 420
ttgatgacaa ataccgctgg agcctgtatt ggatttttag tttattgtct gctgtcaaga 480
atcttgcctg ccaatctgaa aaagcaactt caatccagcc gtgtcaatgc tgtggctgaa 540
gtacttctct ttgctatttg cacatttgcc attatggtca cggctcagac ttggtttgtc 600
catgatgtgc tgaatgttcc ataa 624
<210> 233
<211> 810
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(810)
<223> BLCPAMOF_02450
<400> 233
atgaatacat tgagtttgta tgttcaaaga aatgaagaag taatatcagc tgacagccgt 60
tctcttattt caaaaagata ttgcactgta acatcagcaa tgaaccgtga gttttggaat 120
ataacaagcg atagacaaaa tagtatatat gttggctcct atggaagggg aactgcgata 180
gatacaagtg atattgatat tttgatgtcc ttgccggaat catattacaa ccagttcaac 240
tctgtttatg ggaatggtca atctcgtctt ctgcaagtag ttagacaggc tattcttgtt 300
cggtatccaa gaagtgaagt aagagcagat ggacaggttg tgaagatcaa tttttcagat 360
ggaatgttct ttgaaattct gccggcattc aaaaattggg atggctcata cagatatcca 420
gatacaaata tgggtgggaa ttggcgttca actaatccaa aagcagaaca ggatgccatg 480
aaaaacaaaa atataagcag taatggactg ctttttgaca cttgcaagca tctacgatat 540
gtgcgagata actattttag aagctaccat ttgtcaggaa tagttattga cagcttcgtt 600
tatcaagcaa taggaaattg gagatggctt tcctctggag aaagttcaac ttcagcagca 660
ggtacatacg agaagattct tttagattat tataatcagc attttatgtg gggagcgatg 720
cctcttagtg caccaggaag caatcaacag gtgtctacgg ataacagcag agattgcctg 780
ggtaaagttc ttagatatat tgctggttaa 810
<210> 234
<211> 561
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(561)
<223> BLCPAMOF_02451
<400> 234
atggagaaaa gttcgctgga ttaccgtgaa aaattatatt ctcaaataca agaagaatat 60
ggaaaacttg tatataccta tacatgtcat tttaagatgg ctgatcggtt gagtaagcgt 120
aatttttgga taaaatgggg acagattggg ttatcagcaa tatcaacagg cggctttttg 180
ggagtgctca tttcaaatga acagatactg ttatgggctg gtggactatg ttcaacagca 240
cttcttgcac taacaagcta tctgaaggat aaggacattt ccactgaaaa aaccgatcat 300
attaagactg caaataagct gtggaaggta agagaaaaat atctgtcact tttgacagac 360
tttgacgaaa ttagtattga agaaatagtg cgcaaaagag atgaactgtt ggatgaaagt 420
tcggaaattt actgtgctgc acctttaact gatgggaaaa gttatgctgc cgcccaagct 480
gcgcttaaaa caaatgaaga gcaattcttt acgcaggagg aattaaacaa gatgcttccg 540
gcgcatttga gaaaaaaatg a 561
<210> 235
<211> 201
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(201)
<223> BLCPAMOF_01428
<400> 235
atgatcacgg ataatgcact ggacgccctg acggcgcgga tgctggaagc cgtaaagaac 60
acccgcgaaa gcgcggactc tgctgcagcc agcgcccaga aggcgcagaa gatggcggag 120
ggagagatgc agggaacgtc gctgactggc gcagagaaaa agctgctggt gcagatacaa 180
aatttacgac aacaaatctg a 201
<210> 236
<211> 303
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(303)
<223> BLCPAMOF_00835
<400> 236
atgggtacag atatagaaaa actggttgat ttgatgattc aggagcggat gcagagccag 60
ttcgctaaat ggcgggaggc agaaaccggc aaggagaaaa aagcggacta ccttcgcttg 120
gaaaccgagt atgagaaagc gatcagcgca ttgtctgagg aacagaagga cgctgtaagg 180
cactactgcg attctatctt tgattccggc gcagaaagcg agtgcttctt ttaccggctg 240
ggcctcaaag atggcatccg tctctggaag tttatgaaaa agctgatgaa aacggtcagc 300
taa 303
<210> 237
<211> 183
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(183)
<223> BLCPAMOF_00836
<400> 237
atgagatacc gtatcgaata cgccgatggg cgctactgta actttgccaa cggcagggct 60
gaactgctga aatggttgaa actgctgaag caagaggaaa cctccgacat ccgcaaagtg 120
tataaaagcg gtgtgtcgga ttccgtcctg gaaacatacc ggaattatat ccgtccagca 180
taa 183
<210> 238
<211> 1290
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1290)
<223> BLCPAMOF_00716
<400> 238
atgaaacacc cgcttcagga aatgatggac aagcgccgcc agggtatccg ctgcggcatc 60
ccctcttatt gcagcgccaa cgagctggtc attgagatcg cgctgcgccg cgccaaggag 120
cgcaacatcc ccgtcctgat cgaagccacc gctaaccagg tcaaccagtt tggcggctac 180
accggcatga agcccgccga cttctaccag atggtcctga aaatggccaa ggacatcgac 240
ctgcccgaga acatgatgat cctggcaggc gaccacctcg gtcccctgac ctggcagaag 300
ctgcccgagg ccgaggctat gaagaactcg gtcgagctgg tctaccagta tgcccgcgca 360
ggctttacca agatccacct cgacaccagc atgaaggtgg ctgacgacgc tcccggcctg 420
ctcaagaccg aggtcatcgc acgccgcggc gcgcagctgt acaaggcagc tatgaagggc 480
tacgaagagc tgaaggccga gaagcccgat gcaatgcgtc ccgtcttcgt catcggcagc 540
gaagtgccca tccccggcgg tgctaccgag gctgaggaca cgctggctgt caccagcccc 600
gatgctttcc gcgacaccgt ctctacttac cagcgcgtct ggaccgaaga gggcgtgggc 660
gacggcatga aggacgtcat cgctgtggtc gtccagcccg gcgttgagtt cggcgacgag 720
caggtgttcg actatgaccc tgccgccgct gtggacctct gcgcagccct gaaggagttc 780
ccggacatct gcttcgaggg ccactccacc gactaccaga ccgccaccga cctgtacaac 840
atggtcaccg acggcatcgc catcctcaag gtcggcccgg ccctgaccta cggcctgcgt 900
gaggccctgt tctccctgag catgatggag aaggagcttg tccccgagga aaagcgcgcc 960
aacttcatcg agactctgga ctccgtcatg ctggcctccc ctgcaaactg ggagaagcac 1020
tatcacggcg atgagaagca tctggcacag tgccgcaagt acagctactc cgaccgcgcc 1080
cgctactaca tcggccagcc cgaggtggtg gccgccatga acaagctgtt cgacaatctc 1140
cgcgagtacc ccatcccgat gaatatgctc caccagtata tgcccatcag ctacgcaaag 1200
atccgcgagg gcaagctgaa gctcgacccg cgcgagctgg ccatggacgg catcgtgcag 1260
ttcatgctgg actacgagag cgctgtctga 1290
<210> 239
<211> 1383
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1383)
<223> BLCPAMOF_02061
<400> 239
atgagtttgc caaagcgtga tggcgtacat gaccgctact atctgatcca caagccggac 60
acttccctgg aggtgctggc ggaggcggat ctctgcattc aggatgtgct gaacggaacc 120
gctcgtgaaa atcactccgc ctacccgact gtggtgcgaa atcataacgg aacacccttt 180
ctcccggatc agctgctgga gcggtatctg accgggctgc cgctgaaagg atttccctgt 240
gaggatgctg cctctctctg cgacgccatg cggcggctgg tgggctggca ggagatccgc 300
tatacattgg agaaatacat agaaaagcag gtgcaggaaa ggtattttga ggctggagaa 360
aaagaggatg attttacgcc ttacccgcct tgtactgtgt ggccggagct gcggccggag 420
gatgtggatg aaggcctgct gcgctttgcc tgctatgtgg cggtctgcca tacggtgtac 480
gggcagagtt ttgaatccct caccaccgag cacatcctcg gcctggtctc ccagcttcgc 540
ccagatatgg tgaagcagct gaaaacagcc ggcagcggca aattaccaaa ggacatccag 600
cagcgtaaga cggagcattt caacgcatcg gccaatgatg cgtttgccac tatccgcatc 660
accgccaggg actccacgga ggagtgctat gctgaaatcc tggactacct gtgtgcggtg 720
ctggagcagg aagaatttcc ccgcagttac tcggtggagt tccgtgggaa ggaaaaactc 780
tatctgccca ttcccggctt gccccaaaag ggcgtcaatc agctctttgc ctgtgctgtg 840
cagcaccctg atcttcatcc ggctatggag cgatacgctc gtttggctat gcgggagttt 900
gagtggtatc aaaaccttgc ggatgaagcc tgcgccatgc ctggcacctt tgccgtgttc 960
gccctgggac tggaagggcc gaagtggtgg cggctggtgt gcgattacct ggatcgatgt 1020
gatgacgagc actcctcttt gcaggagaag ttcctgcata ttctgttcaa gcagtacggg 1080
ttcactgccc agtccctgcc ggtgctggtc cacggagtac agtccatgca gaatctgaag 1140
cccgcaaagg agttccgcgc cctgatcgcc aatgaggaga gcctggatgc tctgctggag 1200
atcaaagggc atctggaata ttacctgccg gaagaatccg gcaatgacaa aagggcgctg 1260
gcctacctgt ggcgtgatgt gctctgggcc atctggggca cagcctctga aaacggcggc 1320
agcaaggtta tcaagacagc gcccaaggaa ctgaaagaga aataccagca agtatttgcg 1380
taa 1383
<210> 240
<211> 630
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(630)
<223> BLCPAMOF_01141
<400> 240
gtgccggaca tctcgctgtt ggtgccgctg gccgagcagc tgaacgtgac ggtggccgag 60
cttctgcagg gacgccgggt agaggaggaa cagcgcttca cccgcgagga gaccgaagat 120
ctcatccgca aggcgctgac cttttcggca gagccgccgg agcgccgtca ggcgcggacg 180
aagaagtatc tgccggtgta tgtcatctgc tgcgtgctgg gcgtcgcaga agcgctggcc 240
gtctgggcgg cgggactggc cgacatcgag ggagcgctgg ctctgctcat cgtcgatgtg 300
gttttcggcg tcgtctacgg ggcctatgcc atgttctgga tgaccgagac cctgccccgc 360
tactacgacg agaaccgcat ctgcaacttt gcacagggtg cgttccacat ccacatcccg 420
ggcatctatt acaacaaccg caactggaag cacatcctgc gggcgttccg ggtctggtcg 480
atggcgtcgc tggtgctggt gccgccctgc acggcggggg ctgtcctgct tgaacgcgcc 540
accggctggc aggtgtgggg cgtggtgctg gtggtgtata tcgcctcgct gttcggggcg 600
atcgtgatac cggcgaagag gtttgagtga 630
<210> 241
<211> 156
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(156)
<223> BLCPAMOF_01970
<400> 241
ttgaaagtga gaggtagaaa gctgacccgc cgccagaaag aagccctctc tgctgccggt 60
tgggactgca ccgcatatct ctgggttcgg gatatcccga acggtatggt gctcctgaat 120
aaggacaccg ggaaaaccat catttttgga aagtaa 156
<210> 242
<211> 2493
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2493)
<223> BLCPAMOF_01225
<400> 242
gtgcctgtag agaaacgcaa tattttcctt catgaaacgc agcatgcctt accgtatgtt 60
tcaaaacgaa aaagatcgga tgcatcgttt ccttgccgcg aaaatccaaa ggcgcacgcc 120
gcttttattc ttcaaaaact tgaggcctgc agacagcaag attatgatca gaaacaagta 180
gcggctatta ggcataaaga aggaatctat cttgaatttt caggtgcagc aggatacgat 240
ttgcttacaa aatcctttga caattattct tcaggtatac gtctgcttaa tgtacgcgaa 300
gatgggcaag acgatgaaaa aattgttagg gccactgttt atgttcctgc agaaaaaaca 360
acatatttcc ttgataaaat ccaatcgtat tcagagtcgc tagacacgct agaagccgga 420
caaaatccca aaaacgacag tttagttcgg agtattgaag atgtaaaact tgctttgctc 480
gaggcgtttt gggtaggaaa agtagaggat ataccttctg atgttccagc gtggtgtgaa 540
atatggctcc gatatgaaaa atccgatcat gcagcagcgg agcaagatct ttctacatgc 600
tgtgaagaat tcggaataga actcaattca aagtgtattg tttttccaga acgagtagtt 660
cgactcgtcc gaggtacgcg tacacaatta tcgatgctgc ttgaggggtg caattattta 720
gctgaaattc gtagagcaca agaaccaaca agtttttttg atgagttaac tggttctgaa 780
caaaaagaat gggtaaacga tttgttatca agaacagaat ttcatccttc aagtgcttcg 840
gtatgcattc ttgatacagg tataatgtat tcacatccac ttcttcaacc agcgattgat 900
gagaacaacg tacaagcggt taacgaccaa tggggaaaaa atgaccataa cggacatgga 960
accgaaatgg ctggcgttgc attgtactat gatctcaagg acaaattaag tacttctgac 1020
acagttgatg tgtatcacca tctggaatct gtaaaaattt tgcctcctca cggagagaat 1080
gatccagact tgtatggtgc ggtgaccggg caagctgtat ctttggcaga aatttccaat 1140
ccgaatgcaa atcgtagcat ttgtatggca gtaacatcat cacaatataa tactaacgat 1200
ggaagtccaa catcgtggtc tgctgctgta gacaacattt catccggtgt gggtgaagaa 1260
gatgcaaagc ggttattttt cattagtgct ggaaatgttg atccttctga aatgcacgat 1320
tcaggttacc ccaatgccaa tgaagtacat gtcgttgaga gtcccggcca agcatggaat 1380
gctttaactg ttggagcata cacgaaagat gtctgtgttg atgatgagaa ctacagaggt 1440
tttactcctg ttgcagataa tggacagctt tcgccgtata gtgctacttc tttgatgttc 1500
tctaaaaaat ggccaattaa gccagagata cttctcaatg gcggcaatat ggtgacaaac 1560
ggtaccgatt atgattcgtg tgcagattta tcattgctga ctacaggaaa aaatcatttg 1620
gtaaggccct tttcaacaat ttgggctact agtgctgcta ctgctcaggc ggcatatatg 1680
gctgctcaga tatttgctga atatcccgat gcttggccgg aaacggtacg cgcactatta 1740
gtgcattcag ctcgctggac accgcaaatg gagcagcaat tttgtacaga cacaaggaaa 1800
tccagtggtc gaagacacct gcttcgcaca tgtggatatg gggttcctga tcttgaacga 1860
gcaattcaat gtgtagacaa ttctgtgaat ttaattattc aagaagaaat gcagccatat 1920
gaaaaagcga atggagtatc tcaaatgaaa gagatgcatt tgcatcaaat tccatggcct 1980
tcagaggtac ttcaatcact tggaacagtt gaagttgaga tgcgcgttac tctgtcgtac 2040
tttgttgaac ccggccccgg agaaaaaggc tggaaagatc gttaccgtta tccttcttgt 2100
ggacttcgtt ttgatgtcat caatagcaat gagacaatag aagatttcaa gaaaagagtt 2160
aacgtaaaga tgcgtggaga tgataaggct gacagcggtg acggtagtag cggtagtgag 2220
cgttggtttc ttggttcgga caatcgagat gtcggctcca ttcattcaga ctttattaaa 2280
gcaactgcag cagaactaag ccaagcaaag tatttggccg tctaccctgt agttggatgg 2340
tggagagaac gaagctactt aggaaaagtt gaaagtaaaa tcagatattc cttaatcgta 2400
tctatttcta ctccggatgt atctgtggat ctgtacaccc caattgttgc acagattaat 2460
aatccaatcg aagtggaaat cccaacagaa taa 2493
<210> 243
<211> 714
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(714)
<223> BLCPAMOF_02581
<400> 243
ttgttttttg cagattgtag aagaaagatt atggaaaata aaggaaagaa aaaaagcagt 60
tcaaggaacg atatatcact tgaccaagca atattacagt ggattgtgga tgattatgat 120
atttctgatg aaaaatccag aaaaatagta ggtaaaagtg aagaaaaaag taaattaata 180
acatgcgaaa tggtaatgaa ttatctagac aatcgaggtg tattagaaga aacagatgaa 240
acggaattta tgagatcgct tcgaaagcgt ctttattatg caattgacac agtcgttgga 300
ccaattccaa tgaaatcgaa aagtatcaat gcacatgagc tgctcagaca aaaaagtcaa 360
tcaaaaggac gattttatgt gacttcagca aatgcggaat tttttatgta tttgctttgg 420
tgcaatgaag atagagccga caatgacgat attttgtggt taataaagaa cgaaaggaat 480
tatgaagcaa gtgaatggct gaaaaatttg attagagacg gctttgattc attgattgag 540
aaccctgcaa taggaataaa acaaaaaact gttgaaaggc gatggaagga attatttgaa 600
ggagaattag ccaaaaccaa agatgcatta gaatcattaa atctgacgtg ggcatatata 660
gaagatcgga agaaaatggc aggggatgaa tttgatgaag agtggttgac ttaa 714
<210> 244
<211> 687
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(687)
<223> BLCPAMOF_00310
<400> 244
atgaagccct gtccgcattt tctgaaaaga ttcgcagttc tggcagctgc ctcactgatt 60
ctgagcgcgg tcactttaag tgccagtgcc gcagcagctc ccgtaaagta tgaagaaaag 120
cgttccactg ttaccactgt cgatggcgca cagaaaaagg aagatctggc tgtgaccgtc 180
gaatatcagg tcggctccac ctctatccgg gcttatactg tagaaaagga tgaggtcatc 240
ggtgtatcaa aggatatgtg gtctctttat ggtgccttta cttctgattg gatcaccgat 300
ggcacctata ccctctctca gccgctgaac agtgtggaac agatcactgt aagcgttcct 360
tacggcgaca cagcccgcac gaacgagagt tattttgtat tccatgttcc cgaaggcacc 420
gtcgtcacta ctccttcctg gagttatgac atggaccttt ataagggcaa gaccattgca 480
gatgtaaaag ccgtagtgga agccggtcag gaccccaata ccctcattga cattgaggac 540
gattacgacc ccttcgggcc cgatcttgaa tataccgaca cttctgcgat ctatcacctc 600
cgtaaaggtt acctctaccg cgtaagcgtc agctccgccg aagagtcttt ccctgttccg 660
gagaatttct atttctgtgt agattaa 687
<210> 245
<211> 714
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(714)
<223> BLCPAMOF_00090
<400> 245
atgatataca ttgtgaaaaa acacgagcca agggaattaa cggaataccg tgaaagcgaa 60
tcaagcactg gtgtacgacc gacttatgat tccatgagta gcgacctgca tgagtatgtt 120
ttgtcaaagt tggtggaaga acagggagga ctgtgcgcat actgtatgtg cagaattccc 180
gaaaccgaca aaaaaacagg aagtacattg aagtgtacga ttgagcatat tgaacctcag 240
agcctgacga ggggcactga aaacttgaag aaggaattgg agtacagtaa cttccttgca 300
gtatgctcag gaaatgaaaa ccgaggggct ttatgctgcg ataaatcaag aggaaacaaa 360
aaactttttt tgacaccatt aaatcctgag tgcaatcatt tgatacaata ctctctcagc 420
ggtaagatac aggctgccga aacgatacct gataaggagg acagaaaaga actcgattat 480
gaactaaatg atattctgaa cctaaacgat ggtaaggatt tgaaagccaa gagaaaaagt 540
gctcttgatg gtatgctgtc agtattgcaa aagcagcata aagatcaaga tgttgaagaa 600
tgcagaagaa agttaagaga gctggaaaca cctagaggtc aaaaagttga atacgtcggg 660
attttaatat tttggctaaa gaagcatatt caacatcttg aaagcagagg ataa 714
<210> 246
<211> 162
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(162)
<223> BLCPAMOF_02268
<400> 246
atgctgagcc gcgccgccag tgtattgcgc ggcaagacgc tcatcgtcaa cctgccgggc 60
agcccgaaag ccgtgaagga gaacctcgag tacatcctgc ccagcctcgg gcacggcgtc 120
cgcatcgccg ccggtctgga cggcgagtgc gcccgcaagt aa 162
<210> 247
<211> 1044
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1044)
<223> BLCPAMOF_01947
<400> 247
atgagcgaat ataccatttc gcaggtctat ccgaccgata aaaccgttct ggcccaaatc 60
gacacactgc tgggtcagga gggcatccgc cgcgacggca atctggacta catctgcgcc 120
atgttcgacg aggaatacaa cgtcatcggc accggcagct gcttcggcaa caccctgcgg 180
tgcttcgccg tcagcagcgc ccatcagggc gagggtctgc tgaaccagat catcacccat 240
ctcatcgagg tgcagtgcgc gcgggggaat atgcacctgt ttctctacac caaggtaaaa 300
agctccaagt ttttcggcgc cctcggcttc tacgagatcg cccgggtgga ggataccctt 360
gtcttcatgg agaaccgccg caacggcttc ggggcttatc tgcgcgatct ggaaaagact 420
aggaccgagg gcaaaagtgc ggccctcgtc atgaacgcga acccatttac cctcggtcat 480
cagtatcttg tggaaaaagc cgctgccgcc tgcgacacgc tccacctgtt cgtggtcagt 540
gaggacgcca gcctcgtgcc ttttgccgtg cgcaggaagc tggtggaggc gggcgtggcc 600
catctgccga atgtggtgct ccacgacagc ggcccctaca tcatctcgaa tgccaccttc 660
cccagttact tcctgaagga tgaggcagct gtcatcgacg gccacgcccg gctggacctc 720
gccgtcttta cgaaaatcgc ggcggcgctg aacatcactg cccgctatgt gggcgaggag 780
cctaccagtc aggtgacggg gctttacaac cagatcatgt gcgagcagct gcccaaagcg 840
ggtatcgagt gtgtcgttgt accccgcaaa gaagcaaacg gcaaggccat cagtgcttcc 900
accgtccgcc agtgcctgca gagcggcgac tgggataccc tcgagacgct gctgcccaag 960
accagcctcg actatttccg cagcccggag gcagagccgg tgctggcacg catccgcaat 1020
gcgggcaatg tcgtgcatta ctga 1044
<210> 248
<211> 777
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(777)
<223> BLCPAMOF_00882
<400> 248
atgacagtag gtatggtacc cggggcaagc atcgcaggca tggtgttttc ccttgtcgtc 60
tccttcgcac ttcccatagg cctctttgtt tacgcaaaga agaagctggg tgcgaaggct 120
gcaccgttct ttatcgggtg cggcgttttc tttgtgatgg tgctgatgct ggaagctgcc 180
atccatcgca tcgtgttcca gctggccgga gaagcgctga ccggaagcgt gatcctatac 240
gcagtctatg gcggcctgat ggcagctctt tttgaagaga ccggtcgtta catcgccatg 300
aggtttctgg tgaagccgat ggactttccg aatgccttta tgtatggtgc cggacacggc 360
ggcgtggagg caatgcttct gtgcggcgtg gcatctatca gcaacatcgc aagtgccgtg 420
atgataaact ccggcaccat gtctgcacag ctggcgtctc ttgacgcaaa gaaggcggca 480
gacacggcag cggctctttc ggcgctgtgg acgaccccca gcctgacctt ctttgccggg 540
ggcgtggagc ggatcattgc ggtggtgctc catctgagcc tttcgattct ggtgttccag 600
tccatccgca aaaagtccca gaaagacctg ctcaatgcgt atctgttcca ctttgtcatc 660
gactcgctgt ccgttctgct cagtgcagtg gcatctgtct gggtggtgga gcttgtcgtt 720
gcactcgtga ccggcggggc tgtcctaatg gcaaagtatg cctgtatgga agagtga 777
<210> 249
<211> 1401
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1401)
<223> BLCPAMOF_01948
<400> 249
atggaaacga ctgtttcgct ggtccagatg ctggatgcac gggagcgccg ggtgcagtat 60
cagcaggagc tgctggctca gtaccacaag ccgctcatct gctttaccat gaatatctgc 120
ggcccggtaa aggattcgcc cctcatccag cggggctttg cgcgggggcg tcagctgctg 180
cgccagcagt ttttgcgggc aaagctggcg ccgctgtatc aggacaccgt ccgggaagtg 240
accggctgcg aggcgttcta tgtgctggac gccgacccgc tgaccatcaa gaaattcacc 300
accgacatcg aggacgctac cccgctgggg cggctgttcg acatggacgt catccgcccg 360
gacggcctca aagtggacag agaagagcta aacctcgaag gccgccgctg tcttatctgc 420
ggcgggcctg ctaaggtgtg cagcagccgc cgtatccata ccgtggccga actgcaggaa 480
aagacgacgg agatcctgac cgaggcccgg gacgcgcagg acatcgccga cgcggcccgt 540
ctggccgtcc gcgccctgct ctacgaagtg accaccaccc caaagcccgg ccttgtggat 600
cggcgcaaca gcggaagcca cagggacatg gatgtgttca ctttcatgga cagcgccgcg 660
gcgctctacc cctattttga agcctgcgcc cggacgggcc gcgagacggc ggaacagtcc 720
gcgcccgaga ccttcgcggc cctgcggccc ctgggttgtg aggccgaggg cgagatgctg 780
gacgccaccg gcggcgtcaa cacccacaag ggagcggtct tttcggtggg catcgtctgc 840
gcggcgctgg gacgcctcga ccgctccctt tgggtggatg cagcccgcgt tctgtcagaa 900
gtatccgcaa tgacggcggg cctgaccgag aaggattttg caggcgtcac tgccgagaac 960
gccgccaccg tgggccagaa gctttatatc cggtacggca tcaccggtgt gcgcgggcag 1020
gtggaagctg gacttcccgc agtgctgaat gtcggcctgc cggtgctgga agagggcctt 1080
gccaagggtt acgacttcga ccgcgccagc ggcggcgcac tgctggccat cctggccaac 1140
agcactgata ccaacatcat tgcccgctcg agccgggagc gtcagctggc cctcaccgaa 1200
gagctgaaag cccttctcgc ccagacacct tacccggata aagatgcgct cgcggcgctg 1260
gatgaccggt tcattgcgga aaatctctcg cccggcggca gtgccgacct gctggcgctg 1320
acctggctgc tccattttgt tactactgag gggaatatca atgagcgaat ataccatttc 1380
gcaggtctat ccgaccgata a 1401
<210> 250
<211> 576
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(576)
<223> BLCPAMOF_01667
<400> 250
atgcagacct caaagaatca ttttgaagcc aaagtggtct ttaacgatga gaccatccgc 60
cggatgttcc gcacggagtt ctacacctac gagggaatgc ggcacctgct gtggctcgca 120
gcagcttttg tgctggtgat ggcggcgctg ttcaccgcca tccctaccgt tgtcaaggtg 180
ctctgcctgc tggtgggctg cgccatgttc gccatgccgg actttttgag ccgggtggcg 240
gcagaggggg tcatcatgca gcggggcggc gcggaaacca ccgtgagctg ccgggtcaac 300
gatggcggcg tagacgtgga aaacggtgct cacattccct ttgcaaagat cgaccggctg 360
gtggaggatg accagtattt ctacatcttc cagagccgcc agatggcagt catgatcccc 420
aagggcagcc tgctgccgtc aaacccggag cggttcgcaa aggtgcttgc caaggagacc 480
ggcaaggact ggcagcgctc caagagcctg tgggggctca acctgaaaga cctgatccag 540
atgggaaaag accgctttca gcgcagcgcg tcctga 576
<210> 251
<211> 117
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(117)
<223> BLCPAMOF_01433
<400> 251
atgttttcgc cctatgacaa cgcaaatgcc cgcgaagagt ccgatgctat gcaaaagcta 60
tcccccgaag ataaatccgc ccgatgtcaa gtcttggaca acttttttca caaataa 117
<210> 252
<211> 282
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(282)
<223> BLCPAMOF_01924
<400> 252
atgaaaaaaa ttgaaaatac cgctttgcag atgattgccg aggcttcccg gtgtccagac 60
tacggccccg atatggttaa atcgctgatg aaaaagctgg acatgaacga aaagggcttt 120
gcgcttttga tgaatgttgc cccatccaca gtgcgtcttt ggaccagcgg agctgcacag 180
ccctgcggca cagcaaaacg cctcatgcag atttatgaaa ccggtccgga gattgttggc 240
aagattgcca gagggcagct accggcagat gggagggatt ga 282
<210> 253
<211> 288
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(288)
<223> BLCPAMOF_00720
<400> 253
atgacgatca actgggaagt tatcatctgg acctgcatca cgctggccgt gctcatgagc 60
atcatcggcc tcatcctcta cgctatctcg gccaagaacg tgcgcagcaa gcgcaaggag 120
ctgggtgagg tacacacgga gctgaaagta ggctcccgca tcatgttcgc gggcggcgtc 180
tacggcaaag tggtcggcat cgacgacgag gacactctcc gcgtggaggt ggcccccaag 240
gtcgtcatta ccatctcccg ctacgcagtc cagagcctgc tgaaataa 288
<210> 254
<211> 831
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(831)
<223> BLCPAMOF_01920
<400> 254
ttggaagaaa ataaagatta tcatgcctac cggtatggcg accacttgac gccgggattg 60
gagcttaaaa ttgagcacag cgtagtttgt gaaaatgtgg atatttctac actgatcaca 120
atgggaacag atagcctgga agccatgcgc cagggaagta tcgacgggga gcagaaagcc 180
tatgaaatcg tggtggctgc cgcaaaacag tgggaacagc aggcagcggc aacacagacg 240
atcaaccggg ctttggaata tcttcgtaca cctgagattg aacataccgg caatcagtgg 300
aaagacaccg ataactggag ggcggatcag aaaatcagca accgggtcta tcagatgacc 360
tgcagtattt gggaagatac gaaatatgac agggaaacaa aacagagtat tccggttgcc 420
tggtatgtga catgggaagt ccgtattcat tccccgaagc agggatatgg agaaaagatt 480
gccggacaaa accagaaacg atatacagat aagaatgcag ccataaaata cctggacggg 540
cggaagaaag cctattccca tttattcacg gaaatttccc cgccaattcc gaaagaatat 600
gagcgtcatt ttatggttca tggcactctc ttacctggtt atacggttga aggactggaa 660
cagaccaaaa cggaacatgc cgccgccgag gtttcggagg gcggtatttt tacgccccaa 720
aaccaggaga agccttccgt cctggggaag ctctctgtgg caaaaaccca ggaaaaaacg 780
ccagccgctc ccggtatggc aatgaaaaag aaggaggata tacagttatg a 831
<210> 255
<211> 771
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(771)
<223> BLCPAMOF_01923
<400> 255
atgacggaga cagatagcca gccgattgcg gaaaatgagc aggtcaaaga gctgcttgct 60
ctcctaaaag acaacaatac accgggatat gaagaatttg ccaagctaat cgagcatgtg 120
accgggatgg agcagcgtct tttggaggca accgaggaac taaaggcagt gcgtcaggaa 180
atgcagggat tacagaacca ttccctgaaa gatactctcc aaaagagctg taaagctatg 240
gagatgaata tttccgttat gcgtcaccgt ctttccgaac tcaaaggcca gatcataaac 300
gggtgcagga atatccttgc cgatttcagg gaacgaggta ctgttgcttt gaatgggatc 360
acacagtttt tacatgtcag accggtgttg gagtccattc aaagtgcagc agaaaaaagt 420
atgcaggcca acaacagggc tgttgccaga attgacgctt tcagtacgga atatcacgaa 480
atggagcggc atctcaaaaa tatgggccgt gctattcaag gaaaacctgc ggagacagac 540
gcaaaagaaa atggaaagat tgccagggtg ttcaaaggtg ctttcaaagt ggagggcgct 600
cttatatcct ccattaaccg taatgcggag tgggcactta atacccttgc ccggttggaa 660
cagactgcgg aaaggcgccc ttctgttttg gaagcaatgc gggaacaggc agcaaaaacg 720
gaaccggcaa aaaagcagcc ggcatcttcc catgataagg aaagccggta a 771
<210> 256
<211> 951
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(951)
<223> BLCPAMOF_01434
<400> 256
atgaataaca gtcaggaaat tattttggct caaataagcg caatatatga taaaccacca 60
tttgtgaaag tgaaaacggg tcaaatggaa atgattttga agtgtgttgg attaggaaaa 120
tactatgatg agtatgcaaa atatcttgaa ccatactggt ataatcgggg atttcaaaat 180
gatattgagt catatagaat ttttgttggt ttgaattcga tatttgagga tttgttaaat 240
gcgcataaag gtgaagaaat tatttcgttg ctaacggagt tgggtaatca cattcaagga 300
aatattttgt gtgatggtgg agattttgtc aatgatttta acaggctgtg ccagttatat 360
aatttgatgg gcttgcagat agtttcgaca gaaattgatg aatattcttc taagtttgag 420
gttaagccat atttgaacga aggaaatcat attattcaat cttttggaat ggagcagtgg 480
ttaaaaaaca aatatcagga tgtatatgct tcctatgaga gtgcattaaa ttcatttgaa 540
cgtggtgaca tgggagctgc aattgaatca tgtagaacag cattgacagg gatattttct 600
aaatataaag gagtgccttt tcaaaatgca agatggatgc ttggaatggc aacaataact 660
ggggatttta caggaacaca gcctgcagat gcttccgaga tgactccaat aaaaaatgcg 720
attgaggcaa tgggaaaaag agacatagca gatttttttg atgaaaattt agaggggtct 780
tataaaaaaa caaaggctat ctacagtata tattctatgt tgtcagatta cggaacacat 840
cgattagagg gaacggtaga agtggccaga aacgaagacg cactaatgat gattagaatg 900
accacagaca ttcttgtttg gatttaccaa aagcatggca tgaatgaata a 951
<210> 257
<211> 393
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(393)
<223> BLCPAMOF_01438
<400> 257
gtgaaattag ttgcgattca tcatgtggca atcatcgttt ccgactatga aaaagcaaga 60
gatttctatg tgaacaaact gggctttgca gttgtgagag aaaacttccg caaagagcgg 120
aacgactgga aactggattt gcgtgtcggt gacggagcca atgcgattga attggagatt 180
tttgcagagc cgaacccacc caaacgtgta agcaggccgg aagcctgtgg tctgcggcat 240
ctggcgttcc gggtggatga tgtggaagct accgtggaag aacttgcaca gatgggaatt 300
gaatgtgaac cgattcggtt agatagctac accaaaaaga aaatgacatt tttctttgac 360
ccggatggcc tgcccttgga actgcatgaa taa 393
<210> 258
<211> 552
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(552)
<223> BLCPAMOF_00642
<400> 258
atgccagagt tcccgcgcaa agatttccgg ctccatgtgg gctggcgcac catcaagacc 60
gccgtcagtg ccatgctggt ggccatcgtg tactgtctca tcggccgcaa cccggctttc 120
gcctgcatcg gcgtcatctt cggcatgggc gtcgatatgc aggattccat caaaaacggc 180
ggcaaccgac tcttcggcac tctcatcggc ggcctgctgt ccatcgtggt gttctggatc 240
tacctgctgt tctacccgca gggcggacac agcgtttttc tggccgtgct gctgggcttt 300
gcaaccgttg tcctcatcct gctgtgccag tatttctggc cgggcggcgt ccagcccggc 360
ggcgtggtgc tctgcatcgt tttgttcagc acccccattg agacctatat gagctacgct 420
ctcaaccgca tcttcgacac cgccattggc gtcatcgcag cgctgctggt caactacttt 480
ctgccccggc cccgggtcgt ttccctctgg gaagggttca aaggctcgtt caagaaggac 540
agtaaagtct ga 552
<210> 259
<211> 123
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(123)
<223> BLCPAMOF_02449
<400> 259
atgactgata ctcgaaagaa agcctctatg tcgcaggtgc tggcagatat aaagccttac 60
ataacgaaga agttcatggc ggcaccgtgt ataaataatg ttttgaaatc agggatgagg 120
tag 123
<210> 260
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> BLCPAMOF_02431
<400> 260
atgaacgaga atgttgacgg tatgatgatt cgtctggtcg gccttgcact ggctgtcctg 60
ttgatggctg gcatgaccat ctacacgggc cttttcaaaa agacatccgg catggatgcc 120
cgcgccactg tcatcagtgt gcaagacggc catgtggccg cagaggatgt ccagtggaac 180
gcctga 186
<210> 261
<211> 240
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(240)
<223> BLCPAMOF_02194
<400> 261
atgaaagatt cgacgaaaga agcactgttc aagtttggcg agttctgtga ttccggcaag 60
ccgtggtact gcttttttgg tgtctatctg gtgacgctca tcgtcaatat cacccttctg 120
ctcacctcgg agcggaagcc caagtggtgg agcgtggccc tcgacgtgtg cggtctggcg 180
ctggcggcgt cgaatattgc caagaccgag atgatgcaga aaggccggca taacacctga 240
<210> 262
<211> 864
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(864)
<223> BLCPAMOF_01037
<400> 262
atgaggataa ggagaaataa agtacataag attgttttaa ttgataacgc aagtacggat 60
ggaaccgtcg atttgtttat aaaaggcgga gagtatgaca aaggcgtaat agattatcgc 120
aaaatggaaa ccaaccttgg cggtgcaggt gggttttacg agggaattaa gatttgcaga 180
gatatggaat gtgattacgt ctggattatg gatgatgata cgattccgta tacagattgc 240
ttagaagagc tgatgtctgc cagatctaaa attgagggta aaataggata tttagcaagc 300
tcgattattg gaccggatgg tgagccaatg aatgtgcctg ccattgatat gcgtcctgca 360
aaaaatggat atccgcactg gtataaatat ctgtcggatg gcatcgttca gatttcaaga 420
gcgacttttg tttccatttt ggtttcctat gatgcaatca agaagtgtgg actcccttgt 480
aaggactact ttatatgggg cgatgattcg gaatacacca tgagaatatc aaagtattat 540
gcgccagcct attttgtagg tgctagcgta gctttgcaca agagattcaa cgcaaagaaa 600
ttggatatta tgatggaaaa cgacacaaaa cgattggaaa tgttccgaaa gtattatcgt 660
aatacaacca tcaatgaggg gctttttgta agtcagaagc aaagaaaaaa attggtcatt 720
cacaatttta aggttgcact tcagaaattg cttaaaggtg actttatcag agctaaagtg 780
attttccttg gaaccttgga ttctattact cagagaaaaa agtttgagga atatattgcg 840
aatgaactgt ctttgcaaaa ataa 864
<210> 263
<211> 141
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(141)
<223> BLCPAMOF_02598
<400> 263
atgactacat cggaaattct attgcttttc cagacgatca tcgcactgtt ggcacttctc 60
gtaagtgtcg tacacttgat ggacgaccgg aaaaaggatg attcttatgg cagcaaaagg 120
aaaaagcaca aaaagaaatg a 141
<210> 264
<211> 231
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(231)
<223> BLCPAMOF_01035
<400> 264
atgtgctatt tggtagcaaa agatcgtaat gcacatggtt gttttgctct aaaaacgacg 60
catggaaagc atctggtgga attaaaaaga gaattgaaca gagaggttgg atataaggga 120
gtacagcttg taacaatcag caggccaaca gcgtatggtg agtatgcgcc ttaccacttt 180
gtggatacag aacaggaatt tcagactctt gtaaagggtc ttcgtccata a 231
<210> 265
<211> 624
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(624)
<223> BLCPAMOF_01034
<400> 265
atgaatgagc aattgctgaa aatgaatggc ttatcggtgg gaattttaga tgcactatca 60
tttgagtcgc atttgggaat tccgttgaag aagaacttgc attattttga taaggatttg 120
ttaattgctg aactgatttc gatgactgag tggttggatg aacaggaaat cctttctaat 180
attgcgctag actacagggt taagagcttg gattctatac ttttgaagta tgatcgttac 240
tatccgaatc atcagacacg aaaagtgttt aatgatattc tgggcttccg ggctttttgt 300
gatagctacg atcaaatatt agaagaagag ttttcaccgt tccggattgc tgatatggca 360
aaaggaaagg cagtggatga tggttacagg ggtgtccatg tgtactatca gaaaagtgga 420
agacattacc ccatagaaat ccaatttaat acgttgtttg ataggcaatt aaataactgg 480
cttcacgatt atctgtacaa aaagaattat cccgtggaaa caggggagat aatgcgtgaa 540
aagtatgaaa atggattgat tcggaatgaa catgaattta aggaggtgct gaataatgtg 600
ctatttggta gcaaaagatc gtaa 624
<210> 266
<211> 222
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(222)
<223> BLCPAMOF_02757
<400> 266
atgggaatgt ttcatgtgca tttcggcggc acagaaagcc tttccgaagg agataaagaa 60
tatatcgttc gcattatgga agtaatgccg aaaaaaattg gttgtctgta ctttcctgtt 120
gttgtaatgc cggagcgtaa ggtggtggca tataaggcag tacgcaacaa tgagaaagtc 180
gtgataaaaa gagattgtat caaatgtcaa ggaggaactt aa 222
<210> 267
<211> 201
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(201)
<223> BLCPAMOF_02756
<400> 267
atgaagaacg tgaaaaacaa gaaaatgatg gctgttgttc tgccggaggg atgcttctac 60
ggaaattgta gcgactgcgt ctatgctgac cggagtgact ggagagacgg cgaggtatac 120
tgcctttgcg agaaaggctg gacacacggc tataatcgcc cgagtgaccg gaacggttgt 180
gcctactatg aggaacgctg a 201
<210> 268
<211> 255
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(255)
<223> BLCPAMOF_02755
<400> 268
atgacggttg cattgtgcat gtttgccctt tgggcatggg gcggatggat ctcgtggaag 60
ggcattgaaa acggaaatgg ctggatcggt gttatccttt ccgagaaaat acgcaaaagt 120
ctgaacaaaa aagaaaactg gtggaaaaag gcgcttcttt cggtggcatt cggctatgtt 180
gcaatgggtg caaaggtgat agagtggatt cttacttttg tcatgcgcat ggtggacggc 240
tcgcttttta gatga 255
<210> 269
<211> 999
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(999)
<223> BLCPAMOF_02591
<400> 269
atgtccgaaa atgcaagaca agaagttgtg actcaaaagc cgcgcatggc aatatgctat 60
gacttcgata aaactctttc tcccgatgat atgcagtcgt tcacattgat tccctcactt 120
ggaatgagac ctgaggattt ttggccagag tccaatcaac ttgcaaaaga caaccctatg 180
gacaacaatc tcgcttggat gtatcagctt gttgtcaagt ctaaagctct tagaaaaccc 240
ctcagtcgta gctacttcaa ccaggtagga aaggacgttc ccttatacaa tggagtggat 300
acgtggtttg aacgggtgaa tcagtacggt gaggaaaatg gtattgaagt tcatcattac 360
atcatatcgt ccgggctgaa ggagattatt gaaggaagta atatcgcccg gtatttcagc 420
cgcgtctatg catcgtcgta cctgtattct gcggatggtg ttgccgaatg gccagcacag 480
gccgtaaact ataccaataa gactcaattc atattccgga ttgccaaagg aatctttgaa 540
gagtacgatg agagagtaaa cgatagtgtg cctgagtctg cccttgttac tccatatgag 600
aatatcgtct atattggaga cagtgctaca gatatccctt gtatgcgcct tgtgaagagc 660
aagggcggtt attcaattgg tgttttcgac cctgaaaaga acaagcgtga gaaagtatat 720
caactgttca atgatggtcg aatcaatttt tatgctccgg ctgactactc cgaagattcc 780
gaactgttta agtatatcaa actagttatc ggacagattt ctattaacga aagagtcaaa 840
acagaacaac gaactctgaa aaattcggca gaggcataca atttatacat tactatgcaa 900
tcgttagcag accatatgaa gtctgctgtt tcccccagag agtaccagaa gcttcaacgg 960
gagcttaata agctccaaca tcaaatcgaa ggaatctaa 999
<210> 270
<211> 747
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(747)
<223> BLCPAMOF_01911
<400> 270
gtgattttga tagaacaaga tgcaaagcgg ctgcttatgg aacggctgga cgagtgtttg 60
aaggttcatg cggatatgct ggatgcacag aacatcggca gtatttacga gttacaggga 120
ctttcggaac tccactatta tctgaaggtt gagcatgtat ttactccggc ggaagtagag 180
gcgcttcttt cttttcagga cccgttggat gtagcccgat ggtgttggga agaaaataac 240
catgaacaca gtttcccgat ctgcgatctt ctcaaagaaa ttgatgcagc gcaaaaattt 300
gaacatttca caagcgaacc ttccgcacag gacaaatata cgctcctgat gaaacggctg 360
ggacagaatt actttgctta cagggaaagc cttatgtcaa gagataagga atccttaatt 420
gaaaaagctg ctgaaattac agccatgcag gaggcgtatt cctatctgac aacaaagttt 480
gagttcaggg atgaaatgct ggatgatgtg ctggcgcttg agaatccttt gaaatacttt 540
gcagaccgtt ggcttatgcc ggtttcagat gtgttcgacg tggatatgga tattcgggaa 600
aatattgccg gaatccgaga cagccaggaa tacctgtgtc agagagagcc ggctgtttct 660
gtcctggcac ggctgcaaaa tgcggctcag gaagtgcggg aatgtccggc tgcggagaaa 720
gcggtacgcg attttggtgc acgctaa 747
<210> 271
<211> 141
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(141)
<223> BLCPAMOF_02597
<400> 271
atgactacat cggaaattct attgcttttc cagacgatca tcgcactgtt ggcacttctc 60
gtaagtgtcg tacacttgat ggacgaccgg aaaaaggatg attcttatgg cagcaaaagg 120
aaaaagcaca aaaagaaatg a 141
<210> 272
<211> 1143
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1143)
<223> BLCPAMOF_01038
<400> 272
atggcgatat atttagttgt gtttggactg tctacgcttt gcatttattt agctaaaaca 60
acaaagaata agagtataca gaaactcttg attataatag gattgttgct accggcgatt 120
cttgctggac ttagagctga aaacatagga gtagatgtaa aaagctatgc tatttcattt 180
tttgaaagag caaaacaaag tgatagcata atcaattttt tgaaaaacca atcaattctt 240
ggaaatgcag atataggatt taatttaata gtatatttgg ttgccaaagt agcaaatgat 300
tatcactgga gtttgtttgt ctacgaattg gtcgcagtaa cggtagtgta tatagctttt 360
tgcagatgtg agaagctgta tggaacacca gtgtggcttg tgatgctgtt gtattatttt 420
agtatgtaca atgtatcact gaatattatg agacaaacga ttgcggtcag ttttgttaca 480
ttggcagtta catatttgtt tgataaacaa tataaaccgt attttgttct tatggtaata 540
gcatttgcca tgcattcatc ggctatattg ggatttggca tatttccgat gtatctgttt 600
ttacaagata aacctggcac aagtgaaaaa aagcagtttc tcaaaggaat gtttgcagtt 660
gcagttgttg gtgcgatatc agtaacaatt aacaatcttg ttcggcttct ggttaatatg 720
ggaattttca gagaaaacta tcttaattac ttgagcggtg gtcagttttc aactgtatca 780
gaaggaagat caatttcact gattgttgcg ttaatacagg caacatatct gttgatattg 840
gttgtgcatt ttagatactt aaatagaaga aaaatgcaag ggctatttta tatatttgca 900
tctggtgtcg tctttatgtt tacagtatta ggtcctttgt ttgcagaata tatttcgagg 960
tcaagttatt tctttattcc attgcaaatg ataggattaa gtaatacata tacttgctat 1020
tcggaaaaat ctaaaaatat ttgggcatgg attttgattg ctatattatt cgcaacatgg 1080
tacagagctt atgtgctgtt gaattatgca gcaacagttc catatcaatt ttattgggac 1140
taa 1143
<210> 273
<211> 891
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(891)
<223> BLCPAMOF_02292
<400> 273
gtgactactt atctaagcat ttttacggac accaaatctt gcatgcaaaa atgcgaaatc 60
tgctttgaaa tggggtattt gcttatgttt aaaatcaaca atctggcaaa tcagacaagt 120
cacatcgtca ccgaacagaa gggtatcttc tccattgttg agcacaatgt cgatttctcc 180
gtagcgcctt gcaatgcaat ggaagaatac tatatgagcc agatgaatgt caaacggaaa 240
caggccattg ccaatctcaa cggaaaagtt gggcttgttc tccaagcggg cgcaatgcag 300
tacattgttg gcaacgtgca agcaaccacc gggttgaaag gtgttggtga cttcttaggc 360
aaaatggtaa aaagttccgt cacaaaagaa agcgcaatca agccggagta cgtcggaacg 420
ggtgtgctcg tgaccgaacc cacctataaa tatcttctga ccgaaaatgt cggtgactgg 480
acaggcggtc ttgtaatgga agacggcatg ttcctggcct gtgaatccac tgtcaagcac 540
gagattcagg cacgctcctc gctttcttct gcagcactcg gaaatgaagg actcttcaat 600
ctacggcttg ctggcaatgg tgtatgtgta ctggaaagca atgttccccg ttcggaaatc 660
gtagaaatcg cccttcaaga cgacgtttta aaaattgatg gcagctttgc gatttgctgg 720
tccggcagtc tcagctttac ggttgaacgt tccggaaaaa ccttgcttgg ttctgccgca 780
tccggtgagg gtctggtaaa tgtttataag ggaactggca aagtatggct tgctccatta 840
acgccttctc aatcactggt tagcgcaacg catgcaaaaa gtgcaaagta a 891
<210> 274
<211> 699
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(699)
<223> BLCPAMOF_02291
<400> 274
atggagaaac tggaagcgaa gctgaaagca gtggactggg ccgtgcggga tgtactggtg 60
ggtactatgc gcagcccgca gcagctggat atttgccgga agcactgctt ttattacatc 120
ccggcagagc gcctgcagga cagcagtttt cctatccgct atgtggccct ttaccagtca 180
cagtatgtgt tcggcgcaca ggcaggtgtc cggtactacg gcgaagtcac gaaatgcagc 240
gccgtccgcc ggagcgctat cacagaaatc gacccccgga gaggaacgga agaaaacctt 300
tattaccgct tcgacatccg gaaatggaag cagctgaacc ggcccatcga ggccaaagaa 360
acgggctttg taagggattt taccaacctg ttcctgctgg agcacagtat ccggacgccg 420
gaactctggc tccgcacgga agaggaatac cgcctttgtt cggccctgaa gcgggccgtc 480
tggggcgaca ccatcaacga accggacaac ggccttgcgt ttgaattccg gggcttcacc 540
gtaagctttg cggaggggaa aattttcgtt tcagacgaag gccgcgcttt tgcgcggtat 600
gagatctcgc attttttgca ggatcccggc gctgtggtcc ggggcatccg aagagaatgc 660
ctccagaggg attccatgag ggaactctcg aagatttga 699
<210> 275
<211> 561
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(561)
<223> BLCPAMOF_01837
<400> 275
atgtccgata ttaccatccg taacgccaca ttggccgacg caccccgcat tctggaaatc 60
tacgcctact acatcgagca cacggtcatc actttcgagt acgatgtgcc gtcgcttgcc 120
gagttcgagg accggatgcg ggacatcatg aaaaaatacc cctacctcgt cattgagcgg 180
gatggccgca tcgagggcta ctcctatgcc cacgcttttg tgggacgtgc cgcctacgac 240
tgggccgcag agctgaccat ctacctcgac cacgacgcca ggcgcggcgg actgggccac 300
gtcctctatg aggcgctggc cgaccggctc aaggccatgg gtgtcctcaa cctctacgcc 360
tgcatcggct acccacaggt ggaggacgaa tacctcacca aaaacagtgc ccagttccac 420
gaacatctgg gcttcacgct ggccggtacc ttccacaact gcggctataa gttcgggcgc 480
tggtacgaca tgatctggat ggaaaaaatc atcggcgagc accgccccga tcagccggac 540
atcgtgccgt atcaatattg a 561
<210> 276
<211> 384
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(384)
<223> BLCPAMOF_01830
<400> 276
atgaaaatcg agcacatcgc cctgtacgtc aacgacctcg aagccgcaaa ggacttcttt 60
gtgcgctatt ttgacgccgt gccgaatgcg ggctacaaca acccgcggac ggacttccgc 120
tcctactttc tcactttcgc ggacggcgca cgcctggagc tgatgaacaa acctgggatg 180
cccgacgagc cgaagcctgc cgcccgcgcc ggatacgcgc acatcgcgtt cagcgtcggc 240
agtcaggaaa aggtggatgc gctgacggcc cgcctcaagg ccgacggctg cgaagtcctc 300
agtggccccc gcaccaccgg agacggctat tatgaaagct gtgtccttgc ggtggaagga 360
aatcagatcg agataacggt gtaa 384
<210> 277
<211> 2292
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2292)
<223> BLCPAMOF_01285
<400> 277
atgaacagcc aaaataagga actatctttt cgtataagtt ccggcttgaa aaaccttatt 60
ggtcgtgact taattagtga tagatatata gccgtatttg aactggttaa aaattcttat 120
gatgccggag caagtaaagc tacaatttcc tttgaacagt ctgacgatgg aacggaaaga 180
attattattt cggacaatgg ttgcggaatg acatacgcag acattattaa caaatggttg 240
tttgtggcat attcggaaaa gaagcctcaa catcgtcaac agtcttcctt tcgagataaa 300
attaaacggg aagtagcggg agcaaagggc gtaggtcgtt tttcttgtga tcgcctcggt 360
gcactattaa ccttagtaac taaaacagaa caagataaat acgctaatag agtagaagta 420
aactggaata catttgaatt agatgataca gaagaatttg tgaacatacc agttcattat 480
tccattactg aagaccttcc tggtggcttt aaaagtggta ctacgctgat tatagagcaa 540
ttacgggaag aatgggatcg tgatgcgctc ttgcgcttaa agcgatccct aatgaagctt 600
attagccctg atgctaatga aggagaactc ccatttgata ttgaacttat tgtcgaatca 660
gaacgtgaaa atgatgacaa aactttaaag aaaacaggaa taaatccaga cagagacata 720
gttaatggaa taatccataa tgacattttt gaaaaactaa acattaaaac gacttgcatt 780
gaagtaaata tatcacctga tggggaattg atttctagca agctaacaga tagaggcgag 840
tacattttct cggttgttga gcgtaatcgt caatatcgtg aattgcaaga tattagcatc 900
gtcgtttttt atttaaatca aagtgcaaaa gtaagtttta ctcgccaaat gggaggcgta 960
actcctaaaa gttatggatc ggtttttatt tataaaaatg gtttccgtat taacccatat 1020
ggagatccag gacaagactt ttttggcatt gatcagagaa aagctcaggg atggcgccgc 1080
tttttaggaa ctcgagaaat aatggggcgg atttcaatta agggcgagaa cgatcaattt 1140
gttgaaacaa ctagtagagc gcatggcttt attcgtacta aagcagttga aagtctaaca 1200
acctttttta ttgaaaaggt tttaaaagtt ctggaaaaat atgttgtaaa tttaattgga 1260
tggggtgagc cattaaaaag tgaccccaca catactattt cccctgagga agtaggagaa 1320
caaattatat cccaatttat aaccagcatt gattctaagg atattgttcg tattgattat 1380
aatccagctc tactatcaag aaatgacgaa aagcaagaaa gccttaccac ctcattaaaa 1440
aagcttgaga gtgcagctga gcaggcaaat gacgaagggc ttataagttt agctcagaat 1500
ttaaaaaggc gaacagaagc tatagtttct caaaatctcg aattggaaga agaaaatgca 1560
gttcaagaga gaaaactagc taaggcgtat cgtgaagggc aggcaagaga aaaacaaatt 1620
tattttcttc aaggcagtgc caatcaaaat gttactaatt tgattaacgg ttttcactca 1680
atatatactc ttacagatgc ttcgaaagga tatattaact atttgcgcga aatattagca 1740
cccatagaac ttgaaaacaa agattttgtg ctatccatta ttggccaaat ttatcaagca 1800
aacgaaaagg cccataagct atctgattta gctatacatg gaaatcaatc attgaagcag 1860
agtggagtaa acagcgtata tgattttatt cgccaatata ttgatgaagg acttacaatg 1920
cagggactta aatatgattt agttccttca aatgaggcgt ttaattgcaa attcgatgct 1980
tcttcaatcg gagttattat tgacaatatt gcaagcaatt caataaaagc aggtgcgacc 2040
gtcctacaaa ttaagatgtc tgaaacggcg aaatatgttg aaatagtatt ttctgacaac 2100
ggcattggtc ttgatgagag tattgaccca tccaccttat ttgagtgggg attctcttcc 2160
aatgtaaaga aaaaaggatt tggtatcgga ctttaccata ttaaacagct catagatgaa 2220
atgaagggct ccgtcaatat tgatacttcc tatcacgatg gttttagatt ggttgtgagg 2280
ttaaaaaaat ga 2292
<210> 278
<211> 930
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(930)
<223> BLCPAMOF_01286
<400> 278
atgaacacta catttaaaat attatggttt gaagatgagc ctgcttggtt taatatggaa 60
aagttgcgga ttgaagaaat tctaagaaca cactatctca ttccggttat cgaacggaga 120
gatggtgatg attttgattt agaggagcta accggtaacg actatgactt gattttcatg 180
gattataaat tagcagaagg aaaaaccggc gatactattg ttgctgctat aagaaatagc 240
tacattttaa ctgacattct gttttattca tctgaagaac agaatatgct atcggctatt 300
agaaagcaga tgcctcctat tgatggtgtt tatcttacaa agcgcgacta cagaattttt 360
acagagaagg ccgaaaggat catacaaaag attgttaagc gctcagaaga tgttgttaat 420
ctgcgtggct ttgtcttaga taacactagt gcttttgagg tacggataag agaaattctc 480
aatatttgtt ggcagaagtt taaaccagag cacaaggtcg ttttatctga agcgattgag 540
aaacagttgg aaaataaaag tgctcgggtt gaaacgcaga taaaagctgc caaaggtgct 600
gaatgtacgt ttacttatgc caataataat ccgtatacct tgagtgtagc tgatagactt 660
gatattcttc aagctgttct gccgatttta aatgaaacat atcagatgcc aattactact 720
gtgccacatg attttaagca atattatctt gataaagtaa acgtgtatcg caacaaacta 780
ggccatatca cccttggtga gaaaattatt cgcgtcaatg gacaagatgt ggaaattaat 840
caagatcttc atagactgtt gcgaagaaat atttcagaag ttgatgctac catccagcaa 900
cttgaaatgt atctcaccaa tcatatataa 930
<210> 279
<211> 453
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(453)
<223> BLCPAMOF_01913
<400> 279
atgagtaaaa ccaatacaga aaaaatggcg ccggagacac agacgccgga aatggcaaac 60
ggcatgaagc tggatgtccg cgtgcgtccg attgccccaa tgggaaacct gctggcgttt 120
gccaatgtta cgattggcgg atgctttaag attgacggct tccgtatctg ttccagtgaa 180
aaggggctgt atgtcaatat gcccgcaacc caggataagg gaggcaactg gaaagatgtc 240
tgctggccgg ttacggcaga gttccgcaag cagctcaacg atgccttaat cgatgggtac 300
gggcaggcta ttgaaaattt gcaggcaact cttgaagcga caaagggagc agcggaaaaa 360
ccttccctga ccggtgcatt gaaagaaaat gccggtaagg tcaaagaaca gccggccaaa 420
ccggccacat ctaagaatga gcaggctcgc taa 453
<210> 280
<211> 816
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(816)
<223> BLCPAMOF_01918
<400> 280
atgttaatgg cagtaaatga accttatgcc cttatggtgc agccggacga tattctgatc 60
tctccccgtg aggtagatga acattttggg acgatggtat gcttccatcc ccgctatgcg 120
ctgggcgacc atcacaacta tatggacaaa gacgacttcc tgcgggaaat gtatttagat 180
accgtaggac atgatgaagc cggcatgaaa cgctatgaac ggatggtaaa cattgtaagc 240
agccgtttcc ggcatggacc aaagacagag gaacgggcga tcgatgaagc aatgcagaaa 300
gtaatttcgg aaaagtatct gatgctcccc ctctatctct acgaccactc aggtcttgcc 360
atgagtacag aaagtttctc aggcagggcc cctcatgcag aatgggacag cggacaggtc 420
ggctggatct atgtttccaa agaagatgcc ctaaaggaat ttgacgctga caagatgacc 480
ggcgccatcc ggcagaaagc ggacgcactg atgcgcagtg aagtcgccgc ttacgattcc 540
tatctgcatg gcgaatgtta tgggtttgag ctttataaaa acggggagct gtcggatagc 600
tgctggggct ttatgggtaa cttttccgat gtgttgaaag atatggcgga atacctcccg 660
gatgagtgca aagggatggt cgatcatctg gaggaacagg aacgcccggc tacgatcatc 720
aagacgcttt tgaaacatgc taaaattcag gtcgatcagg cagcaaaagc ctttgaacac 780
gcttcccgac agcaggttct tggggaaagc cggtaa 816
<210> 281
<211> 510
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(510)
<223> BLCPAMOF_01944
<400> 281
atgaaaatag cgatacttgg taccagcggc agcgggaaat ccacgctggc aaagcgcctg 60
ggggagagat acggcctgcc ggtgctccat atggataccg tgcatttcct gcccggctgg 120
gtggagcggc ccttcgccga ggaagaagcc attgtccggc agtttctcga cgagaacgca 180
ggcggctggg tcatcgacgg caattatagc aagacctgct atgcccgtcg gctgaaagaa 240
gcggataaaa tcatcgtgct ctggttttca ccgctggtct gcctttggcg ggcgatacgg 300
cgctggcagc agaacaaagg ccgtgtgagg gagtcgtctg cgcccgggtg tgaagagaag 360
atagatgccg aatttgtccg ctggatcctc cacgatgggc gtacaaagca aaagtgggcg 420
aagatggaga agatcgggga aaagtacccg gagaaatatg tattgattcg gaaccagcgg 480
gagctggatg ggttcttgaa gaaactttga 510
<210> 282
<211> 192
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(192)
<223> BLCPAMOF_01288
<400> 282
atgattgatg gggtcatcaa caatggccgc aagggtgagg agctggaggc ggcaaagggt 60
gaggcgcgcc ggacctcccc ggagaaaaag ccctctatcc gggaacggct ggaggaggcc 120
aaaaaggagt gcggcgagcg caagcccccg gacaaagctc accagaagaa gcccccggag 180
cacgacctat ga 192
<210> 283
<211> 90
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(90)
<223> BLCPAMOF_01617
<400> 283
atgtgtgatg tgcttgataa agtggaaaac agaggcatcg tgaaaggtga gagccgtgct 60
gagctgatga aagagcttgg aatcaactga 90
<210> 284
<211> 825
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(825)
<223> BLCPAMOF_00031
<400> 284
atgaaaaagt ttcttctcgc tcttctgaca gctgtcacgg cggctgcgtt cttctgtggc 60
gcggcagcat ctgtggccac ttacagcgcc agctatgacg caccggccgg catcaacgcc 120
atcgtggtgc aggacaacag cgctgcggtc attctgcagg ccgccgacat cgaccacatc 180
cgcgccgatt acacctacac ctcgagctac gcctttgaaa gctccaagct ctacgacttc 240
acggtggcgg gcagcaccct caccgtgacc aagacccggg agcccaacgc ttcccttatc 300
atccagagcc aggacacccg cagctgcacc ctgacgctgc aggtaccccg ccagacgctg 360
gcaaacatca ccgtcagcac caccaacgac agcatcacgc tggacggcat ttcggcacag 420
accgccagcc tcaccactga caatggccgc atcgaggtat cgaacttcaa cggttccacc 480
ctgagcggca ccacccgcaa cggcaagatc accatgagcg gcgtcacctc ccagaatgtg 540
gctgccacca tccagaacag cggcaccctc aagctggaaa acatctctgc caacgtctgc 600
aacgctaagg tgcagaacgg ctgcatcacc ggctctgtga tcggcagcgg cagctcttac 660
ggctttgagc tggccgcagg cggcggcaag atccgcgtct ccgacgccag cgacaagaac 720
ttcctcttct tcggcaagga cactctgcag cagaatgcag atgcccccaa caagctgaac 780
ctcgccacca agaacggcga cgttgaggtc gagttcgtcc gttaa 825
<210> 285
<211> 270
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(270)
<223> BLCPAMOF_01615
<400> 285
gtgaagtacg gcggcgaaga cctggatgcc ttcaccgagc gggtatacgg ggccgtgaag 60
gacatcgccg aacacacggc aggggagtgc atccttatcg tctcccacgg catggccatc 120
cggcgctttt tgactgaatt cccggaaaag gcgggcgagg tcaccgattt tatcggcaac 180
tgcggcgtcc tcgagatgac atatgcagac ggaaagctga cggtagaaaa aatcatcgac 240
ccgaacggct atctgaaagg cgcgggctga 270
<210> 286
<211> 219
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(219)
<223> BLCPAMOF_02579
<400> 286
atgtgtgatg tgcttgataa agtggaaagc agaggcattg aaaaaggcat tgcaaaaggc 60
gttgcgaaag gtaaggctga gggtgaaatt gaaggcaaaa atcaaatggc tctccttgtc 120
aagaaactcc tcaatcaagg ccgtattgat gatgtcaagc gggcatctga agatgaagtg 180
taccgcgatc agttgataaa agaatttggc attcgataa 219
<210> 287
<211> 453
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(453)
<223> BLCPAMOF_00039
<400> 287
atgtgctgtc ccttccacgg ggataaacac cccagcatga aggtggacag ccgtttccac 60
tgtttcgcct gtcaggcaga tggcgatgtg atcgattttg tcggcagact ttttcaactt 120
tctccctata aggctgtgga aaagttgaag gaggacttcg gcatggcact tgccgacggc 180
aaggtgcggc ttgctccccg cagaccgccc accgtccggc agcagctgct ggactattac 240
cgctgtctgc agcgttggcg ggtccgatat gcaccgcagt cacccacaga agaacttcac 300
ccctgctttc ttgaagcgat aaagaacctt gacatcgttg aatattatct ggactgttcg 360
gtgctcccgg acccgcagac cgaaaacgaa ctacggaagt attgggaggg attgcatgag 420
cgactggaaa aagaggaacg acgattggcg tga 453
<210> 288
<211> 279
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(279)
<223> BLCPAMOF_01207
<400> 288
atgaaactca agaatgtttg tgttaccgtt gctgctctgg tcctggctgt cagcatgact 60
gcctgcggca gctcttcttc tactgctgct tctacctctg aggctgcttc tgctgccgct 120
cagtctgagg ctgcttccac ctctgccgtg gccgaggaga actctgcttc ctctgaggcc 180
gcttctgagg tgagctctga ggctgcttct gaggtttcca gcgaggccgc atcttctgag 240
gctgcttcct ccgaggccgc ttcttccact gccgcctga 279
<210> 289
<211> 207
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(207)
<223> BLCPAMOF_00507
<400> 289
atgaaaaaca aacccgctcc cctgctgaac cccggcaccc tcaagcccat gacggccagg 60
gagctggacg gcgttttctg cgatgagctg gtacagcagg agctggacga caccacggcc 120
tacatcctca gccagctcta ccacgacggc ctgatggagg ccaccggcgt ggagcagacc 180
agcgtctttg aggcagcaga gcactga 207
<210> 290
<211> 201
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(201)
<223> BLCPAMOF_00337
<400> 290
ttgcaactct attatatcca cctgctgggc atcgactaca ccccggtgca gtacgccttc 60
ctcgttgtgc tggctgtggt cgtctccatc ggtaccgtcg gagctgccgc cgctaccacc 120
cttgtggctg ccaccgaagg ccagctggac aaggctgtat acaatggcga ggtcgaagta 180
cctgctgccg aggcagtctg a 201
<210> 291
<211> 957
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(957)
<223> BLCPAMOF_01040
<400> 291
atgattcaag acgcagggtt tcacaaggca acgaccattc ttacagaatg gatttattcg 60
tttcatatgc ctgcatattt ttgcttatcc ggtactgtgt tttcgatgga attaaaaaag 120
aatcgctatt cgtctgtcag caatctgatt agggaaaagg caaaaagact tttgattccg 180
ttactgtttg tatggcttgt ctggaacata ccaattaaaa tgttggcagg gtattatgat 240
ggtttagctc acccgctaat gatggctgtg attcagataa tatttccaaa tgcagtttat 300
ctatggtttt tggaagcact gtttttctgc tttgttatgg attatgtgat tgaaaagcac 360
atcaaaaatg tgggacaaca gttcatgctt gttggaacat tggcattgat agggttgggc 420
ttttataaat atgcacgtca aattgctcct tttggtaatc cgttccgatg gctgatttgg 480
ttttggatag gacattttat tgacaatatt ctaaatgaac taaataaggt atcggaaaac 540
catgggttta ggtcggaagg acaggctttt gtggtagaaa catttttgtt tgcacttctg 600
tatgaaatca gcttttgtac tgcatcaata agatggattt taataaatac cgtaatacca 660
tttattggaa ttgtatggat ttgggagttt gccagaataa ttgaaaatgt attaaggaaa 720
gaacatcata aaaaacttct tgctatttcg caaaatacgt atggagttta tttgtgggca 780
gagccattaa attatttggt tctttcatgt gcaatgaaat ggtttggtat cagtgtattt 840
ggaacggaga tgggggcagc tttgatttat attgttcgtg tcgttggaac agttgcaatt 900
tccgtcctta taataaatgt gctaagaaag attaggtgtc cgataaaagc atattga 957
<210> 292
<211> 483
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(483)
<223> BLCPAMOF_01904
<400> 292
atggtaaata ccatgatttc cattcccggc tatgtccatc tttaccgctc acttttgcgg 60
ttttacgaca tgccggaaaa tgaagtccgg gaaatgctct atcttctgaa tacggcaaac 120
ctggactgct acgagtatta tcacccggac cgcagtgtga tccagagcgg accggtcgct 180
ttttgcggat ggctggaaac gaaagactgc cgcccttacc gcacagaggt acagctttac 240
aagtcgctgc tgtttttgaa gcgcagcatt gaccgtgacc tgatcgtatc agctcagagg 300
gaggctctgc aaaccctgcg ctgtatcatc tccaatctgg aataccgctt ttataaagcc 360
tatggcatgg agatcgagga caaacgcacg gtctatgggg aatgtaccta ccgtctggtt 420
ccaagggagg acgaacccag cgtgtgcctg atgcacgact ggatctacct gccgagtgct 480
taa 483
<210> 293
<211> 618
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(618)
<223> BLCPAMOF_01903
<400> 293
atggcaaatg gctattccaa acagattcag gagcagataa aagcagcggc ggaaggaact 60
attttcatca gttctgattt tgcggatatt gccgatacgg aaaccataag acggaactta 120
aaccggctta cacaggcagg tatgcttcgc cgcattttga aaggtgttta tgaaaaacca 180
aaatatagca aacttctgga tgaatatgtg gcggcagacc cggaagcggt ggcgaacgca 240
ttggcacgaa gttatcactg gacgattgcc ccatgtggga atacagcatt gaacctgtta 300
ggtctttcaa cacaggtaac agcagtatgg tcctatatca gcgatggtcc atataagacc 360
tacgagtgga actctacaaa gctggaattt aagcaccgga ccaataagga gattaccgga 420
ttgtcctata tgacaagttt ggttatacag gcattaaaaa cgcttggcaa atcgaatgtt 480
acgccagaag tcatacagat gctttccgaa aaactgacag acaaggataa acaggcttgt 540
ttgaaggaag caacagagtc tacggattgg gtttacgata cgatacgaca gatttgtgga 600
ggtgaaaagg tacaatga 618
<210> 294
<211> 1401
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1401)
<223> BLCPAMOF_00592
<400> 294
atggaaacga aaaagaagca attcaagatg ccgcatacct tcgtcatcat cggcatcatc 60
atcctgtttg cggtcctgct gacctggatc atcccggcag gctcctacac ccgcttcgag 120
aacgaagcag gcattaaggt catcgacccc aacgatttca actacattga taagactccc 180
gtcaacccgc tcgaaattcc tctgtacatc gtcaatgcct tcatcaagcg cattgatctg 240
atgctggtca tcatgttcgc aggcggtgcc ttccacatcc tgaccaagac cggcgcactc 300
cacgccgtgg ttgccaagat ggcaaagatc ttctccaccc gcatctatct gttcctgcct 360
atcctgacgc tggtcttcgg cctcatctgc accacgcaag gcgtcaacct gttcattgcc 420
tttgcaccga tcatggtcat gatggctttt gcgatgggtc tggactccat caccggtgca 480
tccatcatcc tgctgggcgg cgctatcggt ttctccactg gccctctgaa catcaacacc 540
accatcgtgg ctcagaaaat tgccgggctg ccgctgtatt ccggcgtggg ataccgcttt 600
atctgctttg ctgtgttcta tgttatcacg aacatctacc tcatccgcta cgcactgaag 660
atccagaagc atcctgaact cagccccatg tacgagatcg acaagaccag cgagttccgc 720
aatgctgctg acctcgactc cttcggcaag ctggacgccc gcaagatcct cattatgctg 780
gtcttcttcg catcccttat cctcatcgtc tacggcggca tcaagctcga ctgggatatg 840
gctgagaccg cagctgtctt cctcgcactg gctgtcatcg aaggcgtact gggcggcttt 900
ggtccctctg cgatttccaa agagttcctt gagggctgca agaagatgct gggcgctgcc 960
tttatcatcg gcatggcaca ggctatcagc agcatcatga acgccggcca catcaccgat 1020
actgttgtcc acgcactggc aaacggcctg aacttcgtcc ccaccatcct gctcggaccc 1080
gccatgctgc tggcaaacac cattatcaac gtcttcctga cttccggcag cggtcaggca 1140
gcagctgtca ttcccattct ggcacctctg gccgacctcg tgggcgttac ccgtcagacc 1200
gcaattcttt ccttcaactt cggcgacggc ttctgcaact acgtcctgcc cacttctacc 1260
gctctgatgg gtatcatcag cgctgtgaac attccctatg accgttggat gaagttcatg 1320
tggaagctgt tcctcatctg gatggccgtt ggttctgtgc tgctgatgat cgcacaggca 1380
atccacctcg gccccatgtg a 1401
<210> 295
<211> 840
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(840)
<223> BLCPAMOF_02054
<400> 295
atgttcgaag aattctatga gatgtatgag accgaggagc aggaagtggt cgctctgatc 60
aatcgctgca tcggaggcgg atttaactgg aaaggcaact tttgggaaat gaccgttgtg 120
acgctgggcg tggtattttg tgacaccggc aaggtcagca ccaaagagga gcggctggag 180
tggccggtca ccgatgagga gcgtaacagc gaaaagggct gggaacgctt tcaaaacgag 240
cagatctgcc gcctgaagat ccgccagatg aaagaggaat gggcaaaaga tctggtggca 300
tggccctggt gtatctccca ggtggtcaag gcccacgagg actgtccgga acttcaagcc 360
gttctggacg agtaccacaa gccggtggtg atccaggacc aggtgctggg tgaactgaag 420
ctggacaagg actatgatac cttcgaggga gaaatccagt ggtgcggaaa ggatgtgctc 480
ctttctctgg aggtcaatgc tgaaagcaag ccctcctgga cccgcgcccg cagtgccgcc 540
aagaagctgc tggccgactg tgaaacctgg gacaaagcca tgcgggagct tgcagccaag 600
aacctgaccg agctggccga caactggctt tctcaagatg aggaaaatcc ccgcaatccg 660
aaaacagacc ctatcacaga ggaagaactt gcccgacgaa tcagcatgac gagcctgtcc 720
gtcacctccg gcggcagctt cacagcctgg tttgactgcg atgagatgtt caccgaccat 780
gcggtgactg tctacggctc cttgaaaaag ggcctcaaaa ctgccaacat tgaggggtaa 840
<210> 296
<211> 654
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(654)
<223> BLCPAMOF_01848
<400> 296
atgtatttcc aatacggcga agcggaaacg gcgtatctga gcgcaaaaga cgagcggatg 60
gcggcggtca tcgcacaggc gggacacatc gagagggaag tggataccga cctcttttcg 120
gcggtggtac accacatcgt cggccagcag atctccacga aagcgcaggc gaccatctgg 180
aagcggatgc gggacgagtt cggcgtggtg gatgcagctg ccgtcctcgg agccggggtt 240
gagaagctgc agagcttcgg tatgaccttc cgaaaggctg aatacattac ggactttgcc 300
cggaaaatcg agagcggaga atttgacctc gagggtatcc ggcagaggcc ggacgatgag 360
gccatccggg agctgagcgg cctgaaaggc gtcggtgtct ggacggcaga gatgatattg 420
ctcttctgta tgcagcggcc cgacgtgttc agctacgacg accttgccat ccagcgtggg 480
ctgcggatgg tgtaccacca ccgaaaaatc gaccggaaac tgttcgaaaa gtaccgccgc 540
cggttcagtc cctattgcag cgtggccagc ctctacctct gggcggcagc aggcggcgcg 600
gtgccgggtc tcaaggacta cgcgccggct caaaagccga aaaggaaggg gtga 654
<210> 297
<211> 213
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(213)
<223> BLCPAMOF_02057
<400> 297
atgacccaag aagaacagat ccgactctat cggctgatgg aaaaactcaa ctggtttttc 60
caccaagaga tgcactacct gaatagagat attgcggaaa agaccgcacg ggagtgttac 120
ccggagattc gggattttac atacgatatt ttgtggaatg acctgcccag agaggtgcag 180
ggacaactta tgaacgagga tgagacgcta tga 213
<210> 298
<211> 270
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(270)
<223> BLCPAMOF_02721
<400> 298
atgcgacagg aaacacaatg gacgacgatc ttctgggagg gctggacggc gctggcgctc 60
tgcgcagcgg cagtgttctg gcccggcagt gcggcgctgg gctatccggc tgtgctctgg 120
ccggggctgg cccttgcggc ggcagtcccc gtcctctggg ccgggtggtg gctctgggcg 180
gagaaggccc cgccgctgac ggaggaggag ctgatggcga aaccggggag gatacatatc 240
gagaaggaag aagtagaact ttccgcctga 270
<210> 299
<211> 3759
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(3759)
<223> BLCPAMOF_00933
<400> 299
atgaagacca gtaaccatct gctgcgccgc ctgacggctg cgcttctggc cgctgtgctg 60
gcgctgagca tcgcactgcc agtgttcgca tctgacgacg gcgataccat ttacatcaac 120
agcgtctcgg acctgctttc gctggccaag agctgtgcct acgaccagtg gtcggtgggc 180
aagacggtta ttctacagaa agacctctcc ctcgagggga tgctgtggga gcccatcccg 240
tccttcagcg gacagttcaa gggcaatggc cacaccatct cggacctgac cattacgggc 300
cagtattccc cggcgggcct cttcggcatc gtggaggaac agggctccat cgagtccctg 360
agcgtgcggg gcatcgtgtc tgtctctgac gctgccgaca ccaccaccgg cggcatcgta 420
ggcatcaacc acggtaccct catcaactgc cagttcaccg gcgtcgtcac cggcgacagc 480
gaggtgggcg gcatcgtggg ccgcaacgag tccgaaggca ccatcgacca cagcacggcc 540
cgcgccatcg tcaccggcaa atcttccacc ggcggcatcg caggctacaa cctcggcgcc 600
atcaccggct gcaccaacgt gggcagcatc aacaccgaat atcaggaagc ctctctcgac 660
accgacggct tcaccgccaa gatggtggac cagatcaaca acaagatagc cgccgccgat 720
gacgacgcca ccaattccgt caccaacgtc gccaccgaca ccggcggcat cgcaggccgc 780
tcctccggca tgatcctgac cagcgtcaac accggaactg tcggctacga gcatatcggc 840
tacaacgtgg gcggcatcgt gggccgcacc gacggcctcg tatccggttg tgtcaatcag 900
ggccatgttc tgggccgcaa ggacgtggga ggcatcgccg gtcaggcgga accctatcgc 960
gaactcgacc tctctaagga caccatcaag cgtctccgtt cggagctgga tgttctgcgc 1020
ggccttgtcg atgacaccac cggcgttgtc gagaactcca ccaccagcat ctccaattcc 1080
ttcagcgcca tgaccagcca gatggacacc gccattgcag cggcacgcca gctggacgat 1140
caggccagcg actacggcga cgaggtggcc gacgagatcg accgcgcctc cactctgctg 1200
gccgataccc tcaccaaact cgaacccgtc atggacaccg gcgaagatgc catgaccaag 1260
ctgaccgatg ccaccggaaa cctcaagtgg gccatgcgcg agatggccgc tgagatgctg 1320
atggcatcca gcgccctcag caagaccagc tccggtctgg gcaaggtgag cgacgcggcc 1380
gaggatggcc gtgacgggat gtcggctatc tctgagggta tcaaacagct gttggagtct 1440
gtcgataccg gcgatgacag cgctgcctcg caggcgatct ccaccatcct gaccggctac 1500
gactctctct ctgccgagaa gaagtccgac aagaacctca ggaccggcat tgagctgctg 1560
aaggtggcca actccgtggc cagcgtcttc acgctgggca gcggcatggc cccggcaatg 1620
aaggctgtta ccgcaggcat gggcctgctg cgcacggcgt ccctcctgtc caacgacagt 1680
gacattgccc gtgctacttc ccaaatcgca agtgccatcg gcaccatctc taccattgcc 1740
acccagatgg gcggcatcgt gggcagcgct gccaagtccg tctcggcctc cgaccacccc 1800
gagctggctg cggctctgac caaagcctct gacgcgctgg acggcatggg cagcatcacc 1860
gacggcatca tggacaacat caaggactgg gtcggcaata atggcggcgg cagcatcaag 1920
gacggtctcg atcagctgag cgatgcttcc gacaagctga gcgacgctat ggatgacctg 1980
agcgactccc tcgacctgct caagaccgac gccgccctca ccagcgcaac gctggcgcat 2040
acctccgtgg ctctgggcca gatgcaggac ggcctcggcg gcctgaccga tatgatgggc 2100
cagacccgcg atattctcca ctggctcaac cagcaggacc ctatcaaggt gcctcgtccc 2160
tcggcagagc tgaccaacac caaggactcc ctctttgatg ctgtcagcgc catcaacgac 2220
aagatggacg acatcaacag caccatgcgc accgccagca accagctgac cgacaagatg 2280
cgcgccgtga ccgcacaggt cagcgttgtg tccaacctga tgctggatgc tgtggaagag 2340
atcagcgacc cgggcagcaa gaccatctac gaggatgagt cggaagacct catcgcttcc 2400
cagtccgacg gcaaaattga aaacagcatc aaccgcggca gcatcgacgc cgacatgaac 2460
gtgggcggca tcgccggtac catgggcgtc gaaaacctgc tggaccccga ggaggacaac 2520
aaggacgagg gtacctcgct gctgcgcacc tcctataccg tcagcgccgt cctcaccggc 2580
aacatcaacg agggcagcat caccgccaag aaggatatgg tcggcggcat cgtcggccag 2640
gaggagctgg gccttgtgac ggcctgcgag tcctacggcg acgtcaccgg cgtcaatcag 2700
gtgggcggca ttgccggtgc ggccagcgcc aagctccgca gcaactgggc aaaatgcgcc 2760
ctcagtggtg aaaagtacat cggcggcatc gtcggtcagg gtaccgacag cgacctcacc 2820
gacggcagcc tcatcgccat caacaaccgc gccatcgtct ctgtgctgga aggccagcag 2880
tacgtgggtg ctgtctccgg cggacaggac ggcgacttct atggcaacct cttcgtctcc 2940
gacgatctgc agggcatcga ccgcctgagc cgcgtcggtc aggcagagcc ggtcacctat 3000
gagaccctgc tggctcagga gaatgtgccg gactccttcc gcaagctgaa cctgaccttc 3060
aaggccgacg gccacatcat caagaagatc agctttgact acggtgcgtc cttcactctg 3120
gccgactacc ccgagatccc ccagaaggat ggatactacg ccgagtggag cacacccgtt 3180
ctcgaccagc tccacaccga caccgtggtc aatgtggagt acacgcccta catcccgtct 3240
ctgagcagca gcgtcacccg cgagaacgga cgccccgttt tcttcgtgga cggcttcttc 3300
ggcggttcca acgccgtgca ggtcacccag caggacatca cagccgatgt ccacggtgtg 3360
acagagcagt ggctgctgga gttcaccgat gacggcaatg agacccacca gatccgttat 3420
ctgacccccg gcaaggccaa gggcaaggtc tacgtcaagc aggccgacgg cagctggcat 3480
aaggtggaga cgggcagctt cggcagctat accaccttca ccaccaccgg caccgaggtc 3540
gaagtggctt tcgttcctgc aaagcttccc atctgggcct tctgcgccgg cggcgcagcc 3600
ctgctggtgc tgctcctgct gctggcaaag cgcatcaagt cgaagcgcgg ccccaagggc 3660
gaaaagcccc gcagggagaa gaagggcaaa cagcccgaga tggcggacgc cccggccgat 3720
gagctggata cccccatctc tgagacggat atgcagtaa 3759
<210> 300
<211> 2478
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2478)
<223> BLCPAMOF_00932
<400> 300
ttgaacgaac acgaaaaacc gcagatagac ttcatgcaca agcttgcgcg ccagatcgtg 60
gaacgccgca accttgtgtt cctgtttgtc attctggctg ccatcttcac ggtgttctcg 120
gtgcggtggg tcaaggtcga gaccgatatg accacctacc tgcccaagac ctcggagacc 180
cgcatgggcc ttgacatcat ggacgagcag ttcacgacct acggctctgc cgacgtcatg 240
gtggccaaca tcacgcccac tgaggccgat gagctttccg acaggctcac cgagctcaag 300
ggcgtccaga tgctggacta cgacgacacg accgaccatt ataataagga ctcggtgtcg 360
gccctttact ccatcacctt cgactacccc gaggacgatg accagtgcct cgaggccctc 420
gaccgggtga aggaatacct cgccgactac gacatctacg tctccacctc gctgggcaac 480
acccagcagg agaccattga tgccgaggtg cgggtcatca tggtgtacgt tgccgtcatc 540
atcgtcatcg tcctgctcct gacgtcccag acctacgccg aggtacccgt cctcatcctc 600
accttcgtgg tgggcatgat cctgaacatg ggtaccaact tcatgctcgg caccatctcc 660
ttcgtgtcca actcggtcac gaacatcctg cagctggcgc tgtcgctgga ctacgccatc 720
atcttctgca accacttcaa ggaagaacac cagaccatgc ctctgaagga ggccgtcatc 780
gagtccctga gcaagagcat ccccgagatc agctccagct ccctgaccac catcggcggc 840
ctcgtggcca tgctgttcat gcagttccgc atcggctccg atatggccat ctgcctcatc 900
aagtccatcc tctttgcgat gctctcggtg ttcgtggtca tgcccggcct gctgatgctc 960
ttcggaccct acatggataa gaccaagcac aggaacttcg tgccggagat ccccttcgtg 1020
ggccgttttg catggcgcac ccgcaaggtc atccctgtta tcttcctggt ggtcatcctc 1080
atcggtcacc acttctcgaa cctttgtccc tacgcctacg gctacgatgt catcaaggtg 1140
ccgaagatga acgaatccct catcgcggac cagatgatcg aagaaaactt caccaagtcg 1200
aacctcgtgg cactcgtcta ccccaagaac gacgattaca gcatcgagaa aaagatgttg 1260
gaggagctgg aaagctgcga tgagatagac tccaccaagg gtctgtccaa catcgaggcc 1320
caggacggct atatgctgga agacaagctc accgcccgcc agttctccga gatggccgac 1380
ctggactacg aggccgccca gatgatctac accgcctacg ccatcgagaa cgaggagtac 1440
ggccaggtca tcggcaactt cgcctcctat aaagtgccgc tcgtggatat gttcctctac 1500
gtctgcgacg aggccgacac cggcatcgtc tccctctctc aggaagacct ggacgacctc 1560
cacgacgccc gcgaccagat ggagagcgca ctggcccagc tgcagggcaa cgactacaac 1620
cgcgtcctca tctacctgag cccctctctg gaacccggcc agactactta tgagttcacc 1680
gacaccatcc gctccatcgc ccggaagtat tacccggacg gcgagctgta catggccggt 1740
gacgccacca acgagtacga tttccagaag tccttcgccg tcgataatgt cgtcgtcaac 1800
gtcgtgtcca tcttcatcgt cctgctggtg ctgctgttca ccttccagtc cgtcggtatg 1860
cccatcctgc tcatcgtggt cattcagggc gctatctgga taaacttctc gttcccgtat 1920
ttcatgggga ccaacctcta cttcatgggc tacctcatcg tcagctccat ccagatgggc 1980
gcgaacatcg actacgcgat cgtcatcgcc acccgtttca acgagctgaa ggataagatg 2040
gagcacaagc aggccatgat agagaccatc aacttcgcgt tcccgaccat cctgacttcc 2100
ggcaccatca tgaccgtgtc cggcatcctc atcggccaga tgacttccga cgcctgcatc 2160
gtgggcatcg gccagtgtct gggccgaggc accatcatct ccatcatcct cgtcctcttc 2220
gtcctgcctc agatcctgct catcggcacc cgcatcgtgg accgtacctc ctttgccgtg 2280
ccgaagctgg tggcccgcag cagcggcaat ggccgtatgc gcgtcaacgg catcgtgcag 2340
ggcgagatcc acggctctgt ggccggtacg atgaacgcca tcgtggacgg cgacgtccag 2400
ctgaccgtca tctcgggcaa cgtctctcag gaactggacg acaataaaca acaggaggtg 2460
cagaatgaag accagtaa 2478
<210> 301
<211> 225
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(225)
<223> BLCPAMOF_01925
<400> 301
atgaatggat ctcaacagat ctgctttaca gacagcgccg gaaaagcgct gttttctatt 60
cctgacaatg gtttactttg cctgttctat ggaaacgggg acaggcattt tgctgtttgc 120
catcgtctgg atgacaccca tgcagaaatt gacggggtaa attattcgat gccggacttt 180
gccaaaagga tgaaacacaa ccagatcggc tttgccccgg catag 225
<210> 302
<211> 528
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(528)
<223> BLCPAMOF_01291
<400> 302
atggcagata aggcgatccc ggatatttcc cttggcggtg ctgaacaaaa catgagccgg 60
gaggagctgg cggcggtggc gaaagccatt gccgccctct cccaggagga ccgggacctt 120
ctgggcgctg ttcaggagtc tccctgccgg ctgactacga cggagcagtt tttggaattt 180
gagaaaaatg cggactgctt tgtgctggag ccccatgtcc agacgatgga ggctctgggg 240
tgggagtacc tgaaggagaa actgaccatc gacctgacgg acgacctccg ggccgccatt 300
gaccccgctc ccttcggccg gcacgcattg gaggaggact gcggctgttt caccagccgg 360
gggtatctgt atccctccgg tgacgagtgg cagcatgacc gcccccagga gaagccggcg 420
gaccggaaac cctctatcaa ggagcggctg gagcagagca agcaggagtg catgggaaaa 480
aacaaggcgc cggcgcccca caaggggaag tccgagccgg aactgtaa 528
<210> 303
<211> 357
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(357)
<223> BLCPAMOF_02549
<400> 303
atgggggttt caatcgattt gagcggcctc aaggtaagag gaaatgcacg ggtaatgaac 60
gacgtcaaga taaccggata tgaggatgcg aagatacggg cagaaaacac tgagatagac 120
ggcaatgtgg agtttttgga gcggctggag atagggccgg ttcttgatga ggtacaaagg 180
caactccgaa atctggaccc ctcttcggcg gagtatcgct cactgaaaca aatcgtagaa 240
atgaagaata ctgctccgca gagtattatg aatgcgctga aaaagcatct tgccgatttt 300
tcgcagggcg tgctcagtaa tgttgtggca gcgtatattt ctaagcgttt cccttaa 357
<210> 304
<211> 162
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(162)
<223> BLCPAMOF_00620
<400> 304
atgtcagggt ttgatgggat tttatgcctg taccatccgg gcaattcttt cccgaacttc 60
cgcttctggt acaacgcttg tgatgccgcc atgcttttgc gtagaaaggc ttgcggcaca 120
gcaggcaaat gttgtgatag cagtcagttc cttttttgtt aa 162
<210> 305
<211> 489
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(489)
<223> BLCPAMOF_01298
<400> 305
atgaaacgta tcgcttctct tgcactcagc gcggcacttc tggcctcgct ttcgacaccg 60
gtgctggccg cgtcggccat ctctgtggat gcggccccta cggcagctgt gctggaagag 120
gaaaactctt tgtgggagct tccgcaggca gacacgccgg acatgagcaa cacggtctgg 180
tcgtttgccg gcggctacat cgacggcagc gagatgaccc aggccgagat ggacgagtct 240
ctggaagcat acggcggcac gctgcagttc acctttgacg ccgcaggcgg cgcaaagatg 300
atccagggcg gcggcacgct gaacggcact taccagtatc tcgacgacgg cagcgtgggc 360
gtcatcttcg actacaacgg cgaggagctg cgctacgcct gcatctttac ctggacggac 420
gaggacgagc tgctcatggt agccatctcg gatgcagagg gtgccgacgg cgtttacttt 480
gtccagtaa 489
<210> 306
<211> 1977
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1977)
<223> BLCPAMOF_02542
<400> 306
atgagcaacg aaaaagaaac caaggtatcg gctctcgacg ccaaggccaa ggctctggca 60
aacgaagagg acgaagatac caaaatcgcc aagctgctga agaatatgcc gaaatggcgc 120
ttctattcgc tggcagttct taccgttatc tggacggtgt tccagctcta catcaagctg 180
gtcaagcccc ttgacccgtg gttccagctg ccgctccata tgtgccttgc actggtcgtg 240
gtgtggctgt acaatccgat ggtcgagaaa tccaagagcc acaataagct gtggtggatc 300
tacgacatct tcctcatcgc gtccagctgt tttatctgct ggttcttcct gagccacgca 360
gaacagctca actaccgcat cttcaatgtt gacgttatga ccaccaccga ggtcatcgtg 420
gcggtgcttc tggtcatcaa tgtcatggag gccgtccgcc gcgtggtcag tatgtccctg 480
ttctgggtca tctgcttctt ccttgcttat gcatggttcg gccagtatat ccccggcctg 540
ttccgcttct ccggcatcag cttccccaaa ctgatggaag tcctgatgta cggcgagaat 600
ggcatcttcg gctctccgct ggtcacttct ctgggcaccc tgttctactt cctcgttttc 660
ggcaccttct tctccaactg cggcggcggc ggtgtcctga tcgacggcgg catgaagctc 720
agcgataaga cggtcggcgg ccccgcaaag gcagctgtca tctcttccgg cctgctgggc 780
atggtttccg gttctgcgat cgcaaatgtt tccaccaccg gcgttctgac catccctctg 840
atgaaaaaga ccggttatga ccccgaagag gcggcagcag tcgagtctgt tgcttccacc 900
ggcggccaga tcatgccccc catcatgggc gctggcgcat tcatcatggc cgagatcatc 960
ggtgtgcagt atgcgcagat cgcagcagca gccgtcctgc ccgctgtggc ctacttcctc 1020
gccgtgttca tccttgtcca catgatcgca aagaagaagg gtctgggcaa agactccggc 1080
gtacattacg aaggcaagcc catcctgccc cgcgtgtacc gtctgctgcc catcatcgtt 1140
ctggtcgtca tgatcatcat gggctactct ctgccccgtt ccgcgatcta ctgcaccatc 1200
ttctccatca tcatcgcagc gatctctcct gagacccgca tgagtccccg caagctgctc 1260
cagaccctga tggacggcgt ccgtcaggcc gcaaacattg cgatccccac cgctgcctgc 1320
ggcatcatga tcggcatcgt ggtcaactcc ggcgttgccg tcaagatcgc aaagctcatc 1380
ggtacctctg gtgagggcag tctgttcatc gcactgctca tcgccgctct gggctgcctg 1440
ctgctgggca tggcactgcc taccgtggcc gcttacctga tcgctgtcac tctgttcgcg 1500
tcggctatcc agggtctggg catctccgct ctggtcacca atatgttcat cttctacttc 1560
ggtgtcgtgg ctcagatcac tcctcccgtc tgtctggcat cctttactgc agcaggcatc 1620
gcgggtgcaa gcgcatggaa gaccggctgg aaggcattct ccttcgccat caccgctttc 1680
atcgtcccct ttgcattcgt gtatcgtccc gctatcctgc tggaaggcac tatggtggag 1740
atcatcattg catactgcat cgtcattgca gccacctatc tgctggcctg cggcatcgct 1800
ggctacctgt tccgtcccct gaagatgtgg gagcgcatcg cctgctatgt cgtggccttc 1860
atcttcatcc tgcccagctc catgtctgat attatcggca ttgctggatg cgcactcatc 1920
atggcttact gcttcatgac gggcaagaag aacgccaata aggcacagcc tgcctga 1977
<210> 307
<211> 1095
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1095)
<223> BLCPAMOF_02543
<400> 307
atgaaaaaga tttctcgtcg cagctttctg aaggtttctg gtactatggc agcggctggt 60
gctctggcag cctgcggcgg ctcttcctcc accagcaccg cagcttccag tgaggcagct 120
ccttccgttg aggcaaaggc tgtggatggt ctgcccgata tgagcaaaga gactctgaac 180
ttcagctccg ataaggtcgg ttctggctct tacaatatga tcgttgcaat gtccaaggtg 240
ctggagaagg ctggcggttt ccagactgtc aacgtcaacc ctgactctcc gggcggtatg 300
ggtgctcctt atctgtttgc ttccggcaac accgatctgg ccttcatcaa cggcgctcct 360
gcaaagtggg caatggagga aggcactctg ggcaagcctg ctaccagcgg ctatgcagcg 420
gtcatcggcg gcctgactgc tgtctgctac atcaactgcg tgtccaacgc attcctgcag 480
aagtacaatg tctccaccat cgaggagatc ttcgagcaga agctgcccct gcgcatcggc 540
tgctccgcaa agggctccat ggatgctgag ggcgcttacc tgctgctcga gtacttcggc 600
gtgaccgagg acgacctgaa gagctggggc ggctccatca ccaaccaggg cggcgatgcc 660
aacgcagacg ccatctcgga cggccagatc gacttctaca tcgaccacac ctcttctgct 720
tcttccacca tggctcagat cgctaccagc gtggatgtca ccttcctgca gtggggcgat 780
gacctgtgca gctggttcgt cagcgaaaag ggcttcgacc tcatcaccat cccggccaac 840
tccttcaagg gtcaggataa ggagctgacg ctgcccggca ctcccgactg cgtcttctgc 900
aaagagagcc tgagcgagga cgtcgtctac gccatcacca agagcctgag cgagaaccgc 960
gacgctctgg tggccgagta caattccctg tctccgtggg agcctgagac cgcttgggaa 1020
gagatgaagc gcggcggctg cccgctgcat cccggtgctg agaagtacta caaggaagca 1080
ggctacatga agtaa 1095
<210> 308
<211> 135
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(135)
<223> BLCPAMOF_01191
<400> 308
atgttcacga ttcgcgtgga taagtccatc gtggattttt atgatgacct ggcacggcgg 60
acgaaccgct cccgaaacga gctcatcggg cttgcgctgg atttcgcaaa agataaaatc 120
attgtcgagt cttga 135
<210> 309
<211> 903
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(903)
<223> BLCPAMOF_00744
<400> 309
atgaaaaaga tctcgcgtcg tgattttctg aaagtcactg gtttggtggg cgctgctgct 60
gccctgaccg cctgcggcgg ctctgcaagc tccgccgcag cctctacggc atcttctgcc 120
gccggcagca cggccgcttc cactgcagca ctgggcgctg acactcaggc catcgtggac 180
tgcggtgtcc tgaaagtggg cgtcaagaac gcagttaagg gcttcagctt ccaggatacc 240
ctcaccggcg agtacaaggg cctcgaggac agcctcgcag agatgatcgc agagcacctc 300
ggcgtggacg ttgagttcac cacagttacc gccgccaccc gcggcgagct gctggactcc 360
ggcgacatcg acgccgttct ggctaccttc accatcaccg aagagcgcaa gaagacctgg 420
gacttctcca ccccctacta taccgactac gtttccgttc tggtggagga ctccaccggc 480
atcaagggtc tggctgacct gaaggacaag gtcgtgggcg tctcctccgg ctccacctcc 540
gctcgtgctc tggtcaaggc catgatcgac gagggcgtgc tggacggcgc aaacttcgac 600
gccgacacct tcaacgccga cacttggaag gatggcatct ccttccgtca gtacgacgac 660
tatcccgcca tcagcaccgc actgagcgca ggcgaagtgc agggcttctg cgtcgataag 720
tccatcctcg ccatctacaa gaccgagggc cgcagctaca ttgacgctga gttcagcccg 780
caggagtatg gcgtcgccac caagaagggc agcgacttct ccaccctgtg cgacgacctc 840
gtcaagggct ggctggcaga tggcaccatc gagcagctca tcaaagacaa cggtctggat 900
taa 903
<210> 310
<211> 603
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(603)
<223> BLCPAMOF_00109
<400> 310
atgcttcata gcatttcccg ccgattgacc gaatggtttt tccggcacaa ttgggtcgaa 60
gaaaacaatt acacctggtg tctttatgta gttgaaaaaa aacttcttca attctgtttt 120
cttctgatcc tgtcgatttg ttgcattatt tccaatcaat atttcaacac gcttgttttt 180
atggcaacaa tgtatttttt gcgtcggcga atgggtggat ggcatgctcc ttataattgg 240
atgtgtattc tgctgacaac agtaacaacc ttcattgttc tttatatatt cgcccctgtt 300
ctgatgcgca taaattcgct caccatgtgg acacttgata ttctattgat tctagctgca 360
tttagaacca accctattta tccgccgcaa ctacactttg aacaagaaat catatcttca 420
aaccggaaaa aaaagaattt cacacttgtc tgtattacaa tcatacaagt catttctgtc 480
cagcttgggt tccctcaggt actgattttt agttttaatg gcatactagt cagtatactg 540
cttatagtgg ccgagaaaat taaacagaag catggaggtt ttttgtatga agctgttgaa 600
taa 603
<210> 311
<211> 759
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(759)
<223> BLCPAMOF_00104
<400> 311
atgcctgtat cgcgattctt gattcccttg gtttctactg tttggatctt tagtgtgatg 60
ggggggatgg gaatgcatgt attggcagag caacccacag aagtacaggc ggtaaggcga 120
cagttttcaa cattggagga agtgaccgct gtccaagtcc aggaggaggg gtcgacggtc 180
cgcttcctac cgggggaggg agaggaagtc tgcgtccgct atgcggatac gacagcggaa 240
gcactgtacg agattcaggt cgagaacggc accctggtcg tccaaaaatt aaaagcccca 300
cccccgaaag ttgtcaccat caacggaacg attatgcagt ttgaggtgga cagcgcctat 360
gacctggaga ttgtcctgcc ccagcgtcag tataagtcga tcgttgtaga aaatccgtcc 420
ggaggcaatg tagagatgga ttctattaca gccaaggaaa tctgcactga gttaaaaaat 480
ggatcttcgg tgttttcaaa aacacagtct gacagaataa aatcagaaat tgaaaacggc 540
tccgtagtgt tcgaacatcc aacttcctct caatacgatt gcacggtgaa gaacggagag 600
atcaagggag atgttgtagg caggtatgag gattacacgg taaaggctag ggtcaaaaat 660
ggttcttgta tgttgaaatc tcgcttggat gctgcgaatc aacacgcaat gaatctctac 720
gtggagaatg gtcgaatcga agtccatttt aaaaattaa 759
<210> 312
<211> 777
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(777)
<223> BLCPAMOF_01437
<400> 312
atggttgatg ttgaaaaatg tccttatatt gaatataaaa ttcaaggaat aagtgggatc 60
gttgcaaaag aagaaaaagc cttttgcgta aaagatgatt taataataca aatcgaatta 120
aagcaagaag gactggaaat cactgggctg aaagtactat taaaagaaga tattgtaatc 180
gacgaacaag taaagcaggc aatcagacgg aaaattgagc attttttggt gaacttatat 240
ggaaatccga atgtctatgt gtctaaattt tctatgggaa tattgcagat cttcaatcca 300
aatagcaaga aaactcaata tgagttcagt agtacactgg tgatttctgc cgaatgttcg 360
tgtgcaatac agtgcaatgc tgattatttt aagaaaatgt atgaaaaaca agtgccagag 420
gataaagcgg atgaagttta tcctttgctt tttagtacga tgcgtattga tgatattttt 480
gttcgatatt tgatgcaata tgaaatcctt ttagggcaag taacgaaaga acacacgcag 540
aaggaagtcg ctaattacat aaagaaagtg tataatccgg ccaataaaga tagacagata 600
ggctttcaac caacgagaag gcaaggaaga aagtataaag aagatgatct gacctataat 660
agaaatctac tgggacatgg tgatatagaa aaagtcgttt cagaggagaa aataagacaa 720
ttaagcagaa gtataatgga tgtactctgg ttttcactat ggaataaggc cgaatga 777
<210> 313
<211> 243
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(243)
<223> BLCPAMOF_00106
<400> 313
atgaaaatct atgattttaa tggcaagaaa aatattagcg gagaacgcat tcgagaagct 60
cgaatcaaga tgcatctatc acagaaagcg ttggctgtac ggttaaagct ggaaggagtg 120
gaattagaaa gagactgtat cagtagaatt gagatcggca ctcgctttgt tgctgattat 180
gagataaaga tgatagcaaa gacgttgaat gtttccgttt tgtggctctt agggatcgag 240
tga 243
<210> 314
<211> 177
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(177)
<223> BLCPAMOF_00103
<400> 314
atgaacattt taattcctcc cattgttaac atgccgagag tatgcgatga atgtcctgag 60
gatttgtgtc tcattggata cacaccgcct tgcccgagtc agtgttacga ttttgatttt 120
acgtgcgagc cgatttacaa ttcgtatgag tgttcaggca catttaccat gagctga 177
<210> 315
<211> 600
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(600)
<223> BLCPAMOF_00344
<400> 315
atgatgcagt atgtcagacg atgcagtttt atttgtggag ctgttctcag tctcctgctt 60
ctgctctgca gctgtcagat cggggtagga acaggacagt ttgtccagcc gccagacatt 120
tccccggacg acagctctca gggaaagacg cagcttcttt ctgctctgaa tcaggagtat 180
ttccaccgcg tccagatctc caaccatttt atacagggca gtgactctgc tgctgagaca 240
gtatttctgt atcttgagca gaactccggt ggcgacatca acaaagcggt cgagttgtta 300
gccgaaaatc ccgaagatga atattgccgc gcgaattgtg ccgacgctgt tctgagcaga 360
atttctccct cgtccagcga aacttactgg gtcagttatt ccttcctctc tgccgacatt 420
ctggaggacg gcgtcctgaa agaagatgca gagtttggcc ccgttgccgg aaagctcatc 480
gaccatcgga atcttctggt ttcgtcggat tcttatcagc cttacgactg ccagagatcc 540
ggctttgccg tcggcgtcat cggcggtcag gcgctcgtcg tggcagtgtt cgtttcctga 600
<210> 316
<211> 903
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(903)
<223> BLCPAMOF_01922
<400> 316
ttgaatcagg aaccactacc gcagattcat ttgatccgtg atacagactt atccatcttt 60
gcgtatgagc tccatatttt tgccggagat tttcttaggg aatgcgaatt taatatgcgt 120
tctctggcga caaataccgg ggctgattcc attgccatca tggagaaaaa tcacatgtgg 180
ctttccgacg ctttgtttgc ttattgttct acggcggatc ttcatcaaat gatctcaaca 240
acggagttta tcggagcgag ggttttcctg tttcatacgg atcgcagaga gggcggtcac 300
ttgtacggag atgtcctgat gatggattta gacacgctgc ggcaggatat aaaaagaaat 360
atcctctatc cctgcggcgt caatgtcgaa cgcaaagatg gttcagcggc tacggtcagc 420
ctgaaagaat ggactgaaat ggagctttac gaaaaagatg ctctgaaaag ttggggattt 480
tcttatgccc cgaatcaagt tacggaatgg cagtaccact attccacgat gttcagacag 540
tggatggatc aggcatttcg ttatatgccc caggatttag aagaacgcct gaatatgcaa 600
tatatggagg cagcccagaa cccggatatg gataagtacc gcataccaca gggaacggca 660
aaacagatgc ttctttatga cgaagcccct gtgtatcgcc ttcttccatc cggttcggag 720
aaaattgcgc ccattgcggc agtctctacg ggcctgtggt atgaaaatta ccgggagttt 780
gccattgcac cggaggattt aggcgctctg gacaaactga tccgcaggga aactgaccgg 840
ctcacaggaa acctcccaca acttctcaaa aacgaagaac gccgccctgc cccggagcga 900
taa 903
<210> 317
<211> 390
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(390)
<223> BLCPAMOF_02043
<400> 317
atgaacttta gcgaagcaat gcaaatgctt ggaaccaagt tgcaaggaaa gtacgggcat 60
ttaggattca agtataaaaa atccgacaaa acacttacga ggcacagtaa aaatttcacc 120
tatatgattg cgttttcctc attcggcggg aacacaaagg atagcataag catagaggtt 180
tgctatataa tcaacacccg tccatacgac ccttatggtt atgccaaacc agacgccaac 240
acacaaccac tgttttacag tttgagagac aatgaaatat atcttgatat aggaaatgaa 300
gaaaaaattg acattgcctt tgaggttgtt tgtcaatgga tggataaaat actgattcca 360
aaaatgaatg agctttgtgc taccgagtaa 390
<210> 318
<211> 750
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(750)
<223> BLCPAMOF_02042
<400> 318
atgaacacag aatcattgac agcaaagctc ctggacctgg tcgaaggccg ggaaacacca 60
gaaagttggc ggaactggtg ggacgagcat gagccggaac tggaaaccct gctgagtcgg 120
ggcgaatttc tgaagctaaa gccctgccgg catggtttcc agtgggtccc ggtgtttggc 180
agccaaaagg gagccatcgc cattctggaa aagagcggca cagcatttga ggccagcaat 240
ctctaccagg agcggtatct ggcggagctg gatgcgttct gcaaggagca gaagcgagtg 300
cagcgggaaa agcaaaagga attcaaggcc agccacccag aactatttgg ccgatacccc 360
aagttctcca aggcgttggc aaaggtgctg gacccctctg atgagatcaa gcccgccacc 420
acggaggagc aaatcgggaa tcaagaaagc gtgatggact tcacgctccc ggcccaggtg 480
cgggagtttt tcctgctgac cgcaggcatc aatgtattca caggcgtaat cgttgaactc 540
tctggaacat ttaatttgac catccacgga gagcggtatt gcgtgctggg cgagttctgg 600
aaagaagcgg acggcgacca gctcctgctc cgccccggag aggaaaccat ctggtactac 660
gcccatgagc aggacaaggt caatcgcctc tgcaatgata tgacagaact gctggaaaag 720
aaattagcga ggtatctcaa tgaacactga 750
<210> 319
<211> 480
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(480)
<223> BLCPAMOF_02044
<400> 319
atgaacaaat caaatcaaca tagcttgccc cagtcgttag aagtggccat cgcactatgg 60
gagcaacacc tgaatgaatt tgccgttctc ctctcggatg ccatcccttc cttaaagaac 120
acagactgga ttatagagaa aaagcgagtg tttgtttgtg gctcagatgg ttccaagaaa 180
agaaggcgaa ccgcaagcgg gccctcttac cattctggcg tttcgctgaa ccgctctgat 240
acagaacaga tctggaatca ctttcaggcg tttgcgggag ccattggcct ggatgaggtg 300
gagcggattc ctgccaatga gcaggaactg ggacggtatg atttccgagc gtccaacagc 360
cagacagcgg atagtttcac ttgcctgatc tatctgccgg gcgagtggaa tcaggctggg 420
gtccatatct ctgtatttat cgggccgaga taccgggatg cggatttgca tgagacataa 480
<210> 320
<211> 309
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(309)
<223> BLCPAMOF_02049
<400> 320
atggcatggc gaaaagtaat agaagcctgc atggaggatg tgaaacacca cttcgatgac 60
atccagcagg ccattgagtt tggctgctac atccagccgg acaactactt tgtgtcctac 120
atctttgcca cggactcgca attagagacg gcgcggcaga gcggcctgac ggaacagatc 180
aattcctatc acagagagca gctgataaag agtcattacc ccattgaggg aatcaaggac 240
tgcacctttg cctcacagga ggaatgtgac cgggaatttg gcgggaattg gtattactat 300
ttcaaatga 309
<210> 321
<211> 1176
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1176)
<223> BLCPAMOF_02536
<400> 321
atggcaacca agaaactgaa cggaaccgtt atcgtcacct accgctgcaa cgcgcgctgc 60
accatgtgca accgctataa ggcaccctcg aagcccgagg aagagatcag cctcgagacc 120
atccgcaagc tgccgcccat gtattttacc aacatcaccg gcggcgagcc ctttatccgc 180
acggatctga aggacatcgt gcgggagctg cggaagaagt cggaccgcat cgtcatctcc 240
accaacggct tcttcaccga ccgtatcctc gatctgtgca aagagttccc cgacatcggc 300
atccgcatct ccatcgaggg cctcgagcag accaacaacg agatacgcgg cctcgccgac 360
ggttacaacc gcggctacac caccctgaaa aaactccggg agatgggcat gaaggatgtg 420
ggattcggca tgaccgtgca ggacaagaac gcccccgacc tcgtccccct ctaccgcctg 480
tcggatgaga tggggatgga attcgccacc gccaccctgc acaacagctt ctacttcgtg 540
gaggccaaga acatcatcca cgaccgcccc atggtggcga agaacttcga ggccctcatc 600
aacgagctgc tgcggagcaa ttcgcccaaa aagtggttcc gcgcctactt caaccacggc 660
ctcatcaact acctctacgg ccagaagcgt ctgctgccct gtgatatgag cttcgatacc 720
ttcttcatcg acccctacgg cgacgtcatg ccctgcaacg gcaccaagga taaggaagtt 780
atgggcaacc tgaacaccca gagctgggac gagctgtgga gcagccctga ggcagaggcc 840
gtccgcgcca aggtgcgcca ctgcgaccgc gactgctgga tgatcggctc cgtctcgccg 900
gccatgcaca aatatatctg gaagccgggc ttctgggtac tgacccataa gttcaaggcg 960
ctgttcacca agactcctta cagtatgtat gagctgaaag tctgccgcga ctaccgggac 1020
ggtaaggtgt cgaaggaaga gctggaccgc tgctccacct gcgacctcaa ctgcgtggtc 1080
aataacggcc tgagtgccgc gtcgcaggag cagctgcgcc ataagtccgg cgaggagatc 1140
gtggacgccg atattgccga ccagctcaga cagtga 1176
<210> 322
<211> 798
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(798)
<223> BLCPAMOF_01185
<400> 322
atgctgacca attaccacac ccacaccacc cgctgcggcc acgccgaagg caccgaggag 60
gaatacatcc tcacggccct gcgctgcggc ttcaaggtgc tggggttttc tgaccacacc 120
ccctgggcct acgcgacgcc gggcttcgtc agccgcatcc ggatgctgcc ctcccagctg 180
gacgattacg tcctgaccct gcgcaggctg cgggagaaat atgccgacaa actccacatc 240
cgcatcggcc tcgaggcaga gtatttcccg gcctatctgg gctggctcag agaagagacg 300
gagcggctgg acatcgaata tctcatcctc ggctgccact acgacaccac cgacgagcag 360
gacgccaggg ccagccgctt cggcggcagc ccctccaccg cccacggcag acggtatgcc 420
gaacaggtgg tggaagcgct ggaaacggga ctttaccggt atctggccca ccccgacctc 480
tttttgaacc gggtgacggc cttcgacgcc gacgccgaga aagcctgccg ggacatctgt 540
gccgcagcgg cgcggctgga catccccctc gagtacaaca tggccggact gaccctgcag 600
ggccgtcccg acggctctct gggctacacc cgggacgagt tctggcacat cgcggcggag 660
taccccgtca aggccatcgt gggctgcgac gcccacgccc cctcggagtt ggacgtcgtc 720
cccgccatcg aggaaaagaa ggccttcctg cacagcttgg gcatcccggt gctggacacc 780
ctgccggggc tggaataa 798
<210> 323
<211> 489
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(489)
<223> BLCPAMOF_02550
<400> 323
atgaagttca aagaaagcga aaaatgtatc acagtggatt cgttgaacat cacacgcaat 60
atcatgatgt gggatgagac gatgatacag ctcagcaatg tttcagctat cacgaccaga 120
ccgctgaatc cgatctatgt tccgtggtat cctgctgctg cagtccttct tcttctggga 180
ttgtcgggca tccagtctta tagcggtaag acgatgggat ttctcatgat catagcgggt 240
gcggtgatgg cattctggtg cttcaatatg aactcagagc ggaaggagca gactatcctg 300
acagtccaga tgaactcggg agtgagttac ttctttatgg taaaagaaaa gaagatactg 360
aataagctgc tggcagtgct ggcgaagatc atcgcagatg gcggtgtggg taacgcaagc 420
atttcaatca gtatcaaaga ctgcacgata cgagataatg cacggctttt caacggtgtg 480
aatatctga 489
<210> 324
<211> 453
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(453)
<223> BLCPAMOF_00290
<400> 324
atgtgctgtc ccttccacgg ggataaacac cccagcatga aggtggacag ccgtttccac 60
tgtttcgcct gtcaggcaga tggcgatgtg atcgattttg tcggcagact ttttcaactt 120
tctccctata aggctgttga aaagttgaag gaggacttcg gcatggcact tgccgacggc 180
aaggtgcggc ttgctccccg cagaccgccc accgtccggc agcagctgct ggactattac 240
cgctgtctgc agcgttggcg ggtccgatac gcaccgcagt cacccacaga agaacttcac 300
ccctgcttcc ttgaagcgat aaagaacctt gacatcgttg aatattatct ggactgttcg 360
gtgctcccgg acccgcagac cgaaaacgag ctacggaagt attgggaggg attgcatgag 420
cgactggaaa aagaggaacg aagattggcg tga 453
<210> 325
<211> 108
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(108)
<223> BLCPAMOF_00291
<400> 325
atgaacaaca ctctgacgga tcgatgtgtg aataaaccca acctcaccca cgcccctcac 60
cgggcttcgt cctttcgcct gtaccccacc cattgggacg gagggtag 108
<210> 326
<211> 354
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(354)
<223> BLCPAMOF_00695
<400> 326
atgacagtta aggaatgtta cagccagatg ggcggagact ataacaatgt cctgagccgt 60
ttttacgatg aggcaatgat aaagcgcctg ctgggcaggt ttatcgacca caccagcttt 120
cgtgcgctgg aacaggcgat gaccgagggt gacacgcagg cggcgttcaa tgcggcgcat 180
accctccggg gcgtttgtca gagcctgtcg tttactcagc tgtgcggcac gctggattcc 240
atcaccgagg cgctgcgggg cggcaatatc gctgttgccg cagccgacat ggacaaggcg 300
aagcgggagt atgacgtgac gctcagtgcc atccgtgcct gcatggaaaa ctga 354
<210> 327
<211> 192
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(192)
<223> BLCPAMOF_00111
<400> 327
atgcagaacg attttcgatc cgagctgtac atttctacct gtccccgatg cggcacccgc 60
ctcatgtgtg gaaagatcat cgtcaccggt ttgcaaaaat gttccaagtg caaccggcac 120
tgggtcatcc agatggaaaa gaacaaaata tccgtcacaa gggcatccct ctattttgag 180
gagtttgcct ga 192
<210> 328
<211> 168
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(168)
<223> BLCPAMOF_00110
<400> 328
atgaagctgt tgaataacat cggaaaggaa atcctgaacc gcgccattgt tctcgagcga 60
tttggctggc ctccttcttg catgggaggc gtatatcagc ccgagcgtcc cgtttgtaac 120
tatccccagc cggatcatga aactcctccc aaagaaccca acaagtaa 168
<210> 329
<211> 240
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(240)
<223> BLCPAMOF_02828
<400> 329
atgacaaaat tacagatcag aatgcggcag gtcgatcagg tcaaggaatt tgtagatttg 60
ctgtccaaat atccctatga gatggactta gtctccgggc gatataccat tgatgccaaa 120
tccctgcttg gcatttacag tctcgacctg agcaatccgc ttacccttgt gatttattcc 180
gattcctgcg aagaactgct gacacagctc catgcgttgc tcccagattg catcgtctga 240
<210> 330
<211> 183
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(183)
<223> BLCPAMOF_01684
<400> 330
atgctcctgt ttgcccagat acagctccac gatcatccgt ccgttttcgg tattgcaaag 60
ctcttcattg caataaccgc agagctttcc gtccgcctgt gccacatata cttactgctc 120
tttccgtggg agacttttca actgcacctg ctgcacaaag gacgaagccc agcggctgtg 180
tga 183
<210> 331
<211> 354
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(354)
<223> BLCPAMOF_00911
<400> 331
atgaacgact atatcaacac taccgcaacc actgtactta ctgccgcaca gctctttcgt 60
atcataaaga gctttccccg tgtatggttt tcgctcatca gctctaatcc ttgcgtacgc 120
tatgagtttt tcgtcccgtc cgaagaggtg tttcttgatt ttgaaaatgg tgtaccaaca 180
atttgtgcag gattagatat tgaaaaagac tcctctgcct ccatctcctg cgacacatat 240
caatgccaag ttgattttga ggataatgac atcataagtc ttaacgccaa accacttaca 300
aatggtgata gcagctgtcc taatatcagc atctatgtca cgcagtggct ctaa 354
<210> 332
<211> 1314
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1314)
<223> BLCPAMOF_00915
<400> 332
atgaaaaaga agtcaatatc ttttttatta tgcatcttca tgctattact ttttctcccc 60
acagtttttg ctgttgagcc gctgtctagc gaggaagttg ttgcccaaaa gcgtgcgtgg 120
tatccgttta ttaaaacttg tgaagaaaag ttaaacgaga aagctaaatc tgagtcgctt 180
caagatatta aaattgaccg tattattgtt gaatctgtca aatatcttac tactgaaaat 240
gaagtgaacg ctgccataaa tgaaaaaaaa ttcgttccaa acattactat ctatattcat 300
ttttctgcaa tacatatagt gaaggtttct aaatatattt atacctatat gcctcaaaat 360
gattatgaga atttatataa tgaaacctct tcaaatctaa cagtttctaa ttataatacg 420
aacaattcta ttctttcagg agatttcgac ccatcttttt gcacttttct aggtgatgaa 480
tacgtatata attctgcact atctgggcgc tattatattg cccttgatat tgctgactat 540
aagaaccata tctctactac tgtagaccct accgtatctg aaccctccac ctctgaggtg 600
aaatcatctt cgactgcttc ggggtttcta tcgaaagaga ctagtgactc ttccgcttct 660
ttgtctcttt ccacagaata caccaaaggt caagaaatta ttatttctgg caagacagat 720
ttcaactatt tctacactta cagagatggt ttaaagtata aatgcttttc tctgacaaaa 780
aatggagaac gggtttacgc ttctgtgcgc gaagaccttt atgactacta taagaatgca 840
ttccaaaatc attcgcttac tctaaaaggc acatatgaat ttaccgcaga agatggttct 900
cctgtcgttt cggtctccac acttgttgaa ggaacaaaag aaaccaattt gagaagttac 960
ctctggacag tgaataaggg ctctgttaag aatccaaatt ttaaagcata tgctgatctt 1020
aaaggtgacg gattggtcct ttcagcggct aaagatgggc agtctattac gattgattct 1080
aatccgtggg gcgctgctaa gggttcgcag gcatacaagc ttgataacga ttttgctctg 1140
ttgatgatta aagagttaaa ttctgagtta ggtctgcctg attggctcta taccgaaatg 1200
atgggtacac gcgctcttga tggtcgtcag aaagaagttt tcgattatgt aactgttatt 1260
tggtcctatc atccagatag cggaatcaat atcctctatc gcaaaaataa ctaa 1314
<210> 333
<211> 2154
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2154)
<223> BLCPAMOF_00598
<400> 333
atgaaggaga ccgccccgaa aaagatacgc ttccagacgc tgcgcaccct gtgggtgccg 60
ctggccatcg gcgtcgtcac agtagccgca ctggctgtcg tggtgggtat ggtatggaag 120
gactaccgca ccgccatgat ggacagccag acccggcaga tggagctggt ggtgcagagc 180
accgccgaca gcatccgcgt cctgctggaa gaatacgccg accggctgga ctccatcgcc 240
ggaaaagcgg agggcagcaa agcgttccgc cccacggtgg cccggagcga taccatccgg 300
gacgtctggc tggaaaacag cagcggcgag gtcatctaca gctgctacgg cctcagcgcc 360
gtctgcgatg tcctcatcac ccggacggag gacatctcct actggcagta ccacagcggt 420
gacgagcact atcttgtgat gaagaagaag gccggggatg agacagcctg cctcgtggta 480
gactccacgg tcatgtatca gcagctcatc tcggagatcc atgtcggcag gaacggctac 540
atcatgataa agaatgatga taaccttgtg gtcatgcacc ccgaagccgt tcagtggggc 600
atcaaggtcg tggagggccg ccagcgcatc tatcagggga aggaactgga catgagcagt 660
ctgagtgagc tgctgcgcgc tcagcaggaa gaggaatccg gcacgctgga ctactactcc 720
tactggtggg ccgacccgga tctgccccgg gtgcataaga taagcgcctt tcgtcatctg 780
gacgtggggg gcagcttctg gatcgtcagc gctgtggtgg actacgacga tttctacgag 840
ccggtacagc agagcttcgt gaaggtgatc ctcatcttcg gcggcgtggc gctggtgctg 900
gtgctcttca tgtcccagat gttccggctg caggagcgcg accgccgcag cgcgaccgag 960
atcagcgatc tgaagactct gaaccagatc ctcgaagagc tccaccgcag cgaagagtcg 1020
ctggcccacg gccagcggct gcagatgatg gggaccctca ccggcggcat cgcccatgag 1080
ttcaataact tcctgacccc catcaccggc tatgccgacc tcatcatggc cgacgccgac 1140
ccgggcagcg agatctatga caacgcgatg gagatcagcg aggcggcgca gaaggcgcag 1200
gaggtcgtga aacaaatttc ctccatgagc cggaaaaacg tggagacggt ctacgacgcc 1260
gtgtcggtgg agggactgct ccatcgaacc cggaagctgg tggagacgaa ctgcccgaag 1320
aacgtggagc tgaaggaaga aaatgagctg agcggcgaat gcgttctggg aaacgcgacc 1380
cagctgcagc aggtgctgct gaacatcagc atcaacgcca tccacgccat cggcaccgag 1440
ggcggaaagc tgaccatccg gggcagtgtc gtgccgcgca gtgagctggc ggcgctcttc 1500
ccggaagaga agatctccga agagtggtca agctacgtct gcctgagcgt caccgacacc 1560
ggctgcggca tggacaagga gacgatgcag cacatcttcg agcctttctt caccacaaag 1620
aagaccggcg aaggcaccgg tctcggcctt gctctggcgg accagatcat ccgcacccac 1680
cggggccgta tccgggcgga gagcaccatc ggcagaggca cgaccttcta tgtctatctg 1740
ccggtgctgg aacagcagca ggagcgcgaa cagttgcagt ggggcgtgga cagcaagctg 1800
cgcatcctgg cggcggacga caataacaag gtcctcgacc tgctggacaa agacctcagc 1860
gcgctgggcc tgagcgtgtc cacctgctcc cgccggggcg agctgcgcca gctgctggag 1920
cagcagccct tcgacgtcct tgccatcgac gagagcctga tgagcggcag cggcgtggat 1980
ctctgcatgg ccatccgggg ccgctaccca ggcatgaccc gcatcgtgat gaccaatgcc 2040
cccacaaggg agatcgtgga tgcccgcagc cacggcgtca tcgacggcta tgtggtaaaa 2100
cctgtgtcgg cgtctacgct tctggcgcag ataaggagca gccggaaaga ataa 2154
<210> 334
<211> 693
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(693)
<223> BLCPAMOF_00597
<400> 334
atgtcgtatc atgttcttat tgtagacgat gatccagcaa tttgcaaact tttatcgaaa 60
gttatgataa gcaatgagat ggaccctctc gtcgtcaaca gcggcgcggc ggcgctggac 120
ctcatcgcgc ggcagagcag cacgctggat atgatcctga tggacatcac gctgggcgac 180
atggagggct tcgatgtcat ccagaccatc cggcgcaacg gcgtcaccac gccggtcatc 240
atcatcagcg gccgcaacga ggactacgat ttcatgtacg gcctctcgct gggcgccgac 300
gactatgtca ccaagccctt ccgtccccag attttgggcg caaaggtcaa ggccctcatc 360
cgccgcagca agagcttctc gcaggagaac aaccagcaga tcagctgcgg gcctttcctc 420
tgcgacacca ccaccatgcg cttttataaa aacaatgtgg agctgaacct ctccgagaaa 480
gagcgcagcc tgctgctgct ctttgtgcgc cacccgcagc aggtgttcac caaggacatg 540
atatacgagc agatatgggg caatctcatc gctgtggacg acaacgccat catggtctac 600
atcaaccgcc tgcgcagcaa gatagaggac aacgcccgca cgccccagca catcatcacc 660
atccgcggcg tcggctatcg tttcgtgccg taa 693
<210> 335
<211> 1569
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1569)
<223> BLCPAMOF_00596
<400> 335
atgttgaacg cagtcggcag agaaattccc gaagagatcc tcgagcgcac cggcaaagag 60
gtcttccagg gcaacaacta taaggacggc aaggccttcc agaaggccag cccgaaggtc 120
acccccgtga tgcgcaatga ccacgacaag atggtcaagg acatccacga ggctctggtc 180
atgtgcaatg cccacgacgg catgaccgtc tccttccacc accacttccg cgagggcgac 240
ctcgtggtct gcatggtcat ggaagagatc cacaagatgg gcttcaagaa catcaccctg 300
agcgcaagct ctctgggcaa ggctcatgac gccctcgtcc ccatgatcga ggacggcacc 360
atcgtcaaca tcgagtcttc cggcgtccgc ggcaagatcg gcgatgccat ttctcacggc 420
aagctgaagg gtctggctac catgcgcagc cacggcggcc gtgtccgcgc catcgagacc 480
ggtgagactc acgttgacat cgcctttatc ggcgcaccct cctgtgacga gtacggcaac 540
tgctccggta tgggcggcaa gaccaactgc ggtgtcctga gctatgctta cgtggacgct 600
gagatggctg actatgtcgt cgctgtcacc gattgcctcg tggactaccc caactacccc 660
gcagagatca accagaccaa ggtggattac gtctgcgtcg tggaccagat cggcatcccc 720
gagaagatcg ctaccggcgc tgcaaagccc actaccgacc agcgcaagat cctgatggcc 780
gagtactgca ctcaggtcgt tgcaaacacc ccgtacttca aggacggctt ctcttatcag 840
accggtgtcg gcggcgcatc catcgcctcc accatctctc tgtccaagat catggaagag 900
aagaacatcc acatgggtct gggtgtcggc ggtctgacca agcccatgtg tgagctgctg 960
gaccgcggtc tggcccgcaa gctggtggat acccaggact tcgacctgga cgctgtcaac 1020
aacgtcactt ccaaccccaa ccacttcccc atctctgctg gcgagtacgc aagcccgatg 1080
aacaagggcg ctttcgtcaa caagctggat tacgtcattc tggcctctct ggaagtggat 1140
acccacttca actgcaacgt cgtcgtcggc tccgatggca tcatcaccgg cgcacagggc 1200
ggccatcccg ataccgcaca gggtgcaaaa tgcaccatcg tcatcgctcc tctgctgcag 1260
ggccgcatcc cggccatctg caccgacgtg accaccgtca ccaccccggg cgagagcgtt 1320
gacatcgtcg tcaccgacta cggcgtggcc gtcaaccccc gccgtcccga cctgctggag 1380
gctctgaagg ccgctgactg cgtgcctctg aagaccatcg aggagctgcg cgacatcgcc 1440
tactccatcg tcggcgagcc ggagaaggtc cagttcggcg accgcatcgt gggcatcatc 1500
gaggcccgcg acggcactgt catggacgtc gtccgcgaag tcaagccttt ctctttccgc 1560
gaagattga 1569
<210> 336
<211> 903
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(903)
<223> BLCPAMOF_00595
<400> 336
atgaataatc cgaacaagaa gcgcctgcgc cgcacgatga tgttcctgaa tgcgcagaag 60
cccggcctca tcaaagaccc ctacatctat aaggccgact ccctgatgct ggacctcgag 120
gacgctgtcg ccgagaacca gaaggatgtc gcccgcttca gcctgtatca tgctctgaag 180
actgtggact accgcggtgc agagcgcgtc gtccgtatca acggtctgga cactccctac 240
tggcgtgaag acatccgtgc ctgcgtggcc ggcggctgcg attccatccg catccccaag 300
accgagcacg ccgaggacgt ccgccgcgtg gctgccgcca tcgccgagga tgagaagact 360
tacggccgtc ctgagggcga agtcctcatc atcgccgctc tggagtctgc ccgcggcgtc 420
atgaacgctc tggagatctg cgagtctgac gagcgtctgt tcggcatcgc actgtccggc 480
ggcgactaca ccaaggatct gcagacccac attaccggca ccggcattga gctgatgggc 540
gcccgtcagc agatgatcat tgcagcccgc gcagcaggcg tgcagtgctt cgacaccgtc 600
tataccgacc tgaaggatat ggatggcttc cgcaaggacg tcgagaacat ccacctgatg 660
ggcttcgacg gcaaatccat catcaacccc cgtcagatcc ccatcgtgca tgagatcttt 720
acgcccaccc agaaggacat catcttcgct gagaaggtcg tcaaggagat cgacagcaag 780
aaggcactgg gcatcggcgt cttcaccgtt gacggcaaga tgatcgacat cgccttctac 840
gacggtgcaa agcgcaccat cgatctggcc aaggcatccg gcgtgtataa gggggatttg 900
taa 903
<210> 337
<211> 300
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(300)
<223> BLCPAMOF_00594
<400> 337
atggagatca agaaagcagc cacggctggc actctggaat ccagcgactg catggtgacc 60
gtcgagccgg gtgagggtaa gatcgatttc tccctcgaaa gctctgtcat ccatcagtac 120
ggcaaccagc tgcgcaaggt cgcactggag accctgaaga atctggacat cgacaacgtc 180
cgcatcacca tcgtggacaa gggcgcactg gactgtaccc tgaaggcccg catcgagggc 240
gcggtgttcc gctctgttga ccagtatgag aatctgccct ggggaggtgc cattcgatga 300
<210> 338
<211> 258
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(258)
<223> BLCPAMOF_01868
<400> 338
atggaaaaag aaacaatggg aactgtaatt tcagttataa aacaatggtg gttaaaagtg 60
aatcgtaaac ctgcccgcgt tcatgcgatg gatggcgcag cctttccgca tactatcaag 120
gtcaaatata cgatagacgg caaagattac atctgccgaa aatggattgg cgcaggaaac 180
aaagtccctg acaagggaac aacgattaaa gttatctatt gtgaagataa gccatcgaaa 240
gcaagaattg aactctaa 258
<210> 339
<211> 2262
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2262)
<223> BLCPAMOF_00278
<400> 339
atgcagaaat taaagcagat tccaaagcgg gtgcaccatt ttctaattgg gctggtgctg 60
acggcggtgc ttggggtgct ggcctttgcg gtggtgaaca cctacaccgc ctatacggac 120
atggtggtgc agcaacagca gcagtacctg ctggtgacgg cccgcgccgt ctccaaaacg 180
ctctccctct atatctccgg gcagctgcgg gacattgaaa ttttgacccg ctcgccgggc 240
ttcctcaccg agtttgaaaa ttactacgag acgggcggtg acaccgccct gagggaacac 300
atcgtctcct atatgctcag ccaaaagcgg ggcgtcaagc gcatttacct gctggacaaa 360
aacggcgacg tgatgtacca gtacaacgat tatcctttcc tggaagtctt tgacgaaagc 420
ctgctgcacc tgaaagagtg tgccgccgcc cataccagcg gcattggctc ggtcttccgc 480
atctcgcccc agcactacgg cctaatgctg gtgaacgacg tcattcacgg cagcgagtcg 540
ttgggcaccg tggtgatcgt catcgacctc gaacaggtgt acgaggaata tcttgcgccc 600
ctgaacatcg agaacacggg agacatcatc gtcaaaaacg aaaaaggcac catcatcatg 660
caccccaacg cgaagctgct gacgttcaat ccgttccggc agatccagga gctggacact 720
ctgcctcagt acaagggtct gaacgagctg ctcacacggc agtacagcca ggaggagggc 780
acggccattt accgcgatta ctccaatggc atcgccccgc ccgaggatga gatcgcggca 840
ttttcccgca tgaacgtcaa caacacggcc tggtacgtct cggccgtgct gccctactcc 900
accgtcaaaa acctcatcga ccgcaatgtg ggccagtttg gtatgctggt ggccgccatc 960
ctttttgtgc tgggcgtgtg cgtcatcagc ttttacgcca tgcgcaaaaa ccagcagaat 1020
ttgaagctgg aagccgccta cctcaaggac atcaaccaca ccctgaaaga gctgcaccag 1080
agccgcgagc aggtgtacca ctaccagaaa cttcagacca tcggcgcgct ggcgagcggc 1140
atcgtgcatg agttcaacaa cctgctcacg cccattctgg gctactcgga gttcatccgg 1200
gagcggatgg ggcccgagag cgaatactac gatgacatga gcgagatcta cgaggcgggc 1260
acccgcgcga aagagatcgt ggagcagctg ctgcccttca gccgccgcga gacagactct 1320
accgcctacg gccccgtgaa tttggaagcc gttttgcagg atgacaccaa gatggtctcg 1380
atgatcctgc cctccaacat ccggctcgaa aaagggtata aggatatcca cgccaccgtc 1440
tacggcagcg ccacccagct gcatcaggtg ttgctcaacc tctgctccaa cgctgtgcag 1500
gccatggagg gcaagggcgg caccctgacc gtgcaggcgg agaagatctc cgccgacgcc 1560
ctgcctgcca actatcaccc cgccgtcgcc agcggctttg tgcgggtgcg ggtggcggat 1620
accggctgcg gcatgacctc cgagacgctg gcccacatct ttgatgcctt cttcaccact 1680
aaggcggcag gggagggcac cggcctcggc ctttcggtgg tgcagaacat ccttatcagc 1740
cacggcggct tcattgaggc ccacagcacg gtgggcgagg gcagcgagtt tctggtctac 1800
ctgcccgtca cagcgcaggc agtggctccc gaacgccctg ccgcgcctgg tgcgcccgtc 1860
cggctcaaca gtgggaaaca gcccatcctg ctggtagacg acgaggagcg ggtggcccgc 1920
tacctcaagc gccgcctgac tcgcagcggc tatacggtgg atgttttcac cgatgcggaa 1980
gaggccctcg acgccttttt ggcgtcgccc acccgctggc agctggccct tgtggatggc 2040
accatgccca agtataaggg tactgccctc atccagcgga tgcgcagcga gaacccgaac 2100
ctcgctgcca ttctgatgac cggctttgtg gagcaggatg ccgtgcagat gcagcaggag 2160
ggattgatcg acgagatttt cctgaagccg ctcgattacc gaaagctgac ggaaaagatc 2220
gggaaactac tggcgggtga gcctgattta accactgttt aa 2262
<210> 340
<211> 342
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(342)
<223> BLCPAMOF_01901
<400> 340
ttgttttcaa aggagggatg ctatattacg caaaatgaag tcaatgccgt ttttgacgaa 60
caggtgcggc tctgtgctga taccttgaaa cggaaaacca aagaatacac cggggatgac 120
ccggaccggc tgggtgcatt taaggcagcg gcagctttac agcacacaac gccccagcgt 180
gcccttgccg gtatgctggc aaagcatatt gtttctctat acgatatgtg ctttgccgaa 240
gaagtggttt atccgatgga cacatgggac gaaaagatca cagacagtct taactatctg 300
ttcttactga aagcgattgt aaaggaggga cataccaatt aa 342
<210> 341
<211> 306
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(306)
<223> BLCPAMOF_02241
<400> 341
atggaccata tcattctcgg catccttttt ctggtatggg gcgcggcgga catcctccgc 60
ctcgagctgc ccggcatact gggcaagcga ctgaaatcta ccagcgccga ggcccgccgc 120
ctctggcaga ggcttctggg tgtgctggag cttatcgtag gcggcgggca gctgctgttc 180
tactttttct ccgacaatca gaccgtcacc agcatcatcc tcgcggtgat gatactcgcc 240
gccgtctgca tcctcgggcc gtactaccac tggcggaagc aggaaaaaga gaacacacag 300
gaatga 306
<210> 342
<211> 573
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(573)
<223> BLCPAMOF_00600
<400> 342
atgcgtgaga ccccagtctg caccgcggcc gatgccatct acaagctggc ggcgggcaat 60
ctgaaatacc tgaacgcgga aaacgggagc ggcgatattt cccgccgtat ccggatgtcc 120
acctggacga agggccagtc gccctacgcc atcatcgtca cctgttcgga ttcccgggtc 180
atcccggaga acatcttctc ggcgggcatc ggtgaactgt tcgtcatccg gctggcgggc 240
aacatcatcg acgaccacca gctgggcagc atcgagtacg ctgccggcca tctgggctgt 300
cggctggtgg tggtgctggg ccacacccac tgcggtgcag tggatgccgc catcaaccac 360
gagtccgccg gctatatccg ctacatcacg gacgagatca agaaggccat cggggatgaa 420
acagacccct acaaggccag ctgtctcaat gtccggcaca gtgtgcagga gattgaaaag 480
agcctgtgca tccataacat cgaggaggaa acgggcctgc gggtcgtcgg tgcgatgtac 540
cacatcgagg acggcagcgt cgaattcctg taa 573
<210> 343
<211> 1347
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1347)
<223> BLCPAMOF_00289
<400> 343
atgagcgact ggaaaaagag gaacgaagat tggcgtgatg aggacgaact ggaagaagag 60
gaagaatgcg aatgcccttg ggtagacagc aagggcaaag tgcgtgaaac cgcttactgc 120
cagtaccttt tagagaagca ccccatgatg tgcctgaaac agaagctgtt tgaccagaac 180
ggcgaggtgg acgaggacgc actgctctac gaagtccaca gcgacctccg tgactttgtg 240
ctcgacaacc ttgctaagaa ggagaagcag gttctggacg cactccgtat cgaaacctat 300
acccctgaat ggaaacccca gcttgaccgc atccatctcc agaacggaac ctactttctg 360
gacgagcggg gctttgtgcc ggaaaaggaa ctctgcctga accggctccc tgtggaatac 420
cagcccgatg cccctgcacc gaccaagtgg ctggaatttc tggacggtct gctgatcccg 480
gaggacattc tgaccttgca ggaatatctc ggctatctcc tgatcccgtc taccaaggcg 540
cagaagatgc tggtcatgac cggcaagggc ggcgaaggaa aatcccgcat cggcttgctg 600
ctgaagaagc tgttcgggga agcctctcac tccgaatcca tcctccgcat cgaaacgaac 660
cgctttgcca gtgcaaatct ggagtataag ctggtcatgg tcgatgacga tctgaacatg 720
gtggctttgc ccgaaacacg gaacatcaag tccatcgtca ccgccgagga ccgtttgtgc 780
atcgagcgga agaataagca ggctgtccaa ggcttgctgt acgttcgttt catctgcttc 840
ggcaatggca accttgtggc cgctcacgat gacagcgacg gcttctggcg cagacagatt 900
cttatcacgg tgaaagaccg tgaccctgcc cgggtggata accccttcct tatcgaagag 960
ctgtcagagg agcgtcccgg catcctgctg tggatgctgg aagggttgca ccgtctgctg 1020
gcgaaccgct atcagttcac catcagcgag cgctccatcc agaaccttga agcagccatg 1080
gcggacagcg acaacctgac ccagttcatg caggcaacgg cgtatgtccg cttcaagccc 1140
gacaccgagg aacgctccac ctacctctat cgcgcctaca ccaagtggtg cgaggataat 1200
ctggaatcac ccgttccgca aaagaagttc agccagttcc tgctgaaaaa tgcagggaag 1260
tatggcctga ccttttccaa gcacatcgag ggaaagtacc gcggcttccg gggcgtatgc 1320
gtccaccccg cctttgctgc ggcataa 1347
<210> 344
<211> 90
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(90)
<223> BLCPAMOF_01478
<400> 344
atgcaggctg cagcagatga cgatgtgctg gcctcttcgc tgaagctgat ggaccgcaac 60
aagcacgtat atgaggaact tgcaaaatga 90
<210> 345
<211> 108
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(108)
<223> BLCPAMOF_00040
<400> 345
atgaacaacg ctctgacgga tcgatgtgtg aataaaccca acctcaccca cgcccctcac 60
cgggcttcgt cctttcgcct gtaccccgcc cattgggacg gagggtag 108
<210> 346
<211> 636
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(636)
<223> BLCPAMOF_01475
<400> 346
atgaaacgaa aaaaattcct tgccctcgcc ctcgcgggcg tgatgaccgc agcgaccctc 60
accgcctgcg caccgctgga ggacctctac gactggttct ttggcggcgg gtcgagcagc 120
gcttcccgcg ggaacggcac aggccttgat gagtcggaga cgctcgaaaa tggcatcatc 180
cagtggtttg gacttcccag agccaacagg caaaaggacg aggcagagcc gatgcttcag 240
gaagtggcaa agagctttga cccggagagc tggcactaca acaacggcaa tctgaacggc 300
gagctgaacg ataccgccaa agccgcgctt gacaccatcg caaaggataa gctgacggag 360
actcacttgt ataagcgtac agcggtggat gtatgggagg tgcagcccag tcagacagac 420
tttgattttt ctgagaacag atggctttat tatgattggc ttgagcgggg cggagttcac 480
tcagatactc cgactcattc ctcgagttgg gagccttaca gcaggttgaa aagctcgata 540
caaagcacag acgcgtttga tttatacgcc ggtacgttcc aaaaaaacgg caaaacctac 600
gccgcaatgg ttatgattcg ttggagcaac agctga 636
<210> 347
<211> 690
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(690)
<223> BLCPAMOF_00283
<400> 347
atggagcgtt caaaaatctt agtcgtggat gatgaaaagc tggtgcggcg gatgattgcc 60
cgcgtgctgg aaagcgaggg catgtccatt gtggaagcat ccaacgggct ggacgccgta 120
cagatggcca aggcccagcc ctttgacctc atcatccttg atattattat ggaggggatc 180
gacggttttc aggtcatcca ccagctgcga agcgagggga tgctgacgcc cgtattcatt 240
ttaagcggac gtcaggccga caacgacaag gtctttgcac tgggcatcgg ggccgatgac 300
tatatcacca agcccttctc accctcggtg ctctgcgcca aggtcaaagc ctgcctgcgt 360
cgaatgagtc tttccgctcc cagcagcagc ggcgtgctct ctgccggacc gttctgctat 420
ttcagtgacg agatgcggct attgaaaaaa ggcatcgaag tccctctttc cagcaaggag 480
agcttcctga tgaagtattt cctcaccaac cagaacaagg tgctgaccaa agagcagatc 540
taccacagca tctggggcga caatgtggta gacgacaaca ccattatggt acatatccgc 600
cgcctgcgca cgaaaattga ggatgacccc aacaagccgc tttatctgcg cacaatccga 660
ggcgtgggat accagttcgt ggcagaatag 690
<210> 348
<211> 1077
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1077)
<223> BLCPAMOF_00282
<400> 348
atgaaaaaga tgatcacccg ccgcaacttt ctgaaggccg ctggcgtttc tgccgctgct 60
ctgggcctgg ctgcctgcgg cggttccggt tcgtctactg ccgcttcgtc caccgccggt 120
tccgctgcgg catcggccgc tgcttccgac tggacctggg agcgcaaggt cacgctggtc 180
tgcccctggg gcgtcggcgg cggtgctgac ggcaccctgc gccccctgca gcccgtgctg 240
gagcccatcc tgggtgttcc tgttgagatc gtcaacgtcg aaggtgcagg cggcgcaaac 300
ggcatcgact ttacctgcaa gcagcccgct gacggttata cttacgttct gggcacccag 360
tcccacatca tgctggacct gcagaagatc ctgcccgtgg atttcaagaa agagctgcgc 420
cccgttgcaa agctggtcca ctccatcaac atcatcgcct cttccaagaa ggcacaggaa 480
ggcaagtact ccaacttcac cgagttcgtg gactacgcaa aggcacatcc ccaggaactg 540
acctgcggca tgttgaccgc taccggcgcg gactctgtgg ctctgaagca gaccctggca 600
ggcggccttg gctgtgacat taccgaagtg gagcagtacg ttaaggtcgt caactacagc 660
tccggctctg agctgtccag tgccatggtc ggcggccata tcaacatcaa catcaccggt 720
gctgatgaga tcatgggcct catccagtcc ggcgacatcg tcccgctgat ctccatttcc 780
gaaaatcgca tgtccaccct gcccgatctg gagtgcaccg gcgagctggg catcgactcc 840
tacgttggta cctggcgcgg catcctctgt cgtaccgata cgcccgatgc cgccgtaaac 900
gccatggcag atgccctgaa agaagcatgg aacacccccg attatcagga gttcctgaag 960
aatgcctgct acctcgaccg tcccggctac gccgacgctg aagagttcca gcagcttatc 1020
gacgaagagt acaccacctt tgaagactac ctgaagggtg caggtctgat ccgataa 1077
<210> 349
<211> 522
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(522)
<223> BLCPAMOF_00281
<400> 349
atggctctgg aactgatcgt caatctgctg ctgattgcgg gcggcatctt ctgctttgtc 60
aatgtcagta ccactatgcc ccactcggcc gtcaatgagc tgggtgccga gcagtggccg 120
caggctatcc tggtgctgat gctcatcgcg ttggcgttca acgtcatccg tttcttcaag 180
atcaataaaa aagaagatat caaggctggc ttccaggatt tctttcctgc catcggccgc 240
tttgtcaaga gcaagctttt cctcggcatg gtgctggtgg tggtcatggc gctgatgtat 300
gagccggtgg gttttatgct cacctgcctg ctgttcctgt ttgcctacgg cctgctgctg 360
ggccagcgga acatccccat gctgatcctc tcttccgtca tcatcaccat catcctgtac 420
atcggcttcg ccgtgtttct gggcgttctg ctccctcgcg gacagatcct ccccctacgc 480
aacttcgccc tgttcgttga gtcgctcgtc ccgcgtttct aa 522
<210> 350
<211> 1527
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1527)
<223> BLCPAMOF_00280
<400> 350
atgctagatt tgttaaccag cggcctgtcg gtcgtttttg ccccgaagat gttcatcctt 60
atcatcttcg cggtcttcct tggcacgttg ttcggtgctc tgcccggcgt ttcggccacc 120
atggctgtca ccctcggcat ccccttcacc tataagatgg acgctgtcag cgccatcgca 180
ttccttgttg caatttactg cgcatccatc accggcggcg gcatgacggc catcctgttc 240
aagatccccg gcgtcccgtc ctccgccccg actacttatg acggttaccc catggcacag 300
cgcggcgaag ccggcaaagc tctgggcgta cagctcatcg cctcggccat cggcggcatg 360
ttcgcagccg tgtgtatgct gatcttcagc cctcagctga cccaggctgc cctgagcttt 420
ggcccctcgg aactgtttgc catctccttc atgggcctgt ccatcctgac aagcctggaa 480
gaaggcaatg tctgccgcac catcatctcc ggcctgctgg gtctgctgct ggcctgtatc 540
ggcctggacc ccctgctggg cgtgccccgc ttgaccttcg gcacccgttt cctcacctcc 600
ggcattgaaa tgatccccgt catgatcggc ttcttcgccg tcaccgaagt cctcaagcag 660
accaacaagc cttccaagct gaaggctgtc accggcaagg acggcaaggc ggatatgtct 720
gccaaaatgc ctaccctgaa agaaatgtgg agcctgaagg gtgtcatcgc ccgctgctcc 780
atcctcggca cggtcattgg catcctgccc ggtgcaggcg ctaccatcgc ttcgttcctt 840
tgctactcgg aagagcagaa gatctccaag caccctgaaa agttcggtac cggctgcctg 900
gagggcatcg ccgctcccga gtcaggcaac aacgccgcca ccggcggctc catggtcccc 960
ctgctgagcc tgggcatccc cggcggcaac gcggctgcca ttatgatgag cgctcttgtg 1020
ctcaagggcg ttaccatggg ccccctgctg ctggtcaatc agccccagtt cctgtcggcc 1080
acatttgctt ccatgtttgt ctccaacatc gtcatggtct ttgcagccat gatcatcgcc 1140
cgcatcttcg tgcaggtgct gaaaatcccc tacagcatcc ttggccccac catcatcatg 1200
atggcgacca tcggcgctta ctctaccaag aacacggcag ttgacgttat cctgatggcc 1260
atctccggcc tcatcggctt cgtcttctcc acctgcaagt tcaacagctc ggccatgatc 1320
ctcggtctgg ttctgggcgt catctgcgag tccaacctcc gccgcgcata caccatcgtg 1380
gccggtgata ccctgatgga agcaaccatc aatatcctga cccgccccgt caccgggatc 1440
atcatcctga tctgtatcct tgttttgttg agccccgtgt acaagcctct gctcaaaaag 1500
cataacaaag aagcagccgc gaagtaa 1527
<210> 351
<211> 267
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(267)
<223> BLCPAMOF_00369
<400> 351
atgacagaag aagaaattga agcggccgca aaaaaggccg aatatgctgc gcttgatctt 60
gcgtcaaagt tgtttgctgt cgatgatgca cttgaaaaag cattagctca gaaactgcaa 120
tttgaaagcc tgtgcaaaaa aacatcaatt tcagataaaa caatcaattc gttcaagaag 180
gaagttctcc attacgtcga ttaccttgca gaaaaaatta ttagggaggc gctaaagaat 240
ggctcagatc gtgaagcgaa agaataa 267
<210> 352
<211> 642
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(642)
<223> BLCPAMOF_01761
<400> 352
atggaatttc tgagtcggaa ggcagtttgg ctgcctcgct gggctgtttt cgtcagccca 60
ggtcggatac acctcactgg acgccacgtt ggcgatatag ctgcggaacg agacggtgac 120
gttccgggcc gaggcggcgg gcttgccgag gtggacggtg atgttcttgg ggatgatgac 180
ccggtccagc acccgcggca cacaggcgag ggcgggggtc gggccgctgc cgccgtcgcc 240
ggtgaagagg ctgtggggcg ggatgacgat gggggtgttg agggggtccc gcatctcctc 300
ggtgtcgggt atcatctcgg gctgggccag cgtcacctgc ccggggaaga cctgcacgcc 360
caggatgcgg acggtgcggt agccgggttt ggaggccaca aggctgcaga ccgcgtaggg 420
gggctgcgtg gtgttgttct cgtccagcga gagagcacag gctggggtgg taagggtgac 480
atcgtcggcg ttgccttcgg cgtcggtcag gcgggtggcg gtgaagccgt cgccgctgac 540
agtgacggtc acgccctcga cagggctgga ctgacgggcc gcaaaggcct ggatgcggag 600
agttccggtg ttcttcatgg agatacgctc ctttgctggt aa 642
<210> 353
<211> 345
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(345)
<223> BLCPAMOF_01889
<400> 353
atgaagggca ggcataacaa aaaatctgtc cgcgtcgaat ttgtcatgtc cgaagcggag 60
gccgaactgg taaaagaacg catggcggaa cttggcatta ccaatctgtc ggcatatctg 120
cgaaagatgg ccgtagacgg ttacatcatt caccttgata tgggagacat tcaagaaatg 180
atccggcttc tccgcatttg ttccaataac ttaaaccaat ataccagacg ggccaatgag 240
accggcaata tttatgccgc agatatagag gacatccgca cccgtctgga cagactttgg 300
gatggcatgg acaaactgat ccggggattt gcaaacattt cataa 345
<210> 354
<211> 690
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(690)
<223> BLCPAMOF_00680
<400> 354
atggagaaaa agacgagctg cctgctctgc gttcttaccg cgctgcttct cgctgtgctc 60
tatctctggg ccgctctccg cccgggcgtc tggctgcggg atgccttttt gtatcgtcag 120
gccgacggca gcttttcggg caaggatgcg tatgccgcct acaccatgca ggttgctcag 180
acggaaaacg gtgcggaagt ggagttcacg atagacggag agacgcggca ctatcggctc 240
gaatcgaaag ccgagggcat gagcgacccg ggcgtaaaaa ttgagcagga cggagtggtc 300
atttttaccg ggaccgcgct gggcgacccc ggcgacgcca tcctgtggag ggaagacgat 360
gggggccttg ccgacgaggt gaacgtcatc gtcaacggcg aataccagag atccgacctc 420
tggcccagct gtaactggct ctataatgtg gccgtcggcg ggcggcggga gacccggggc 480
agcgtggcgt tcctgctgcc gataggggcg ctggtggtgc tccttgtgct ggatgtccgg 540
ttcccgctgc tgttctggaa cctccgtcac gggctggaag tgtacggcgg tgagcccacc 600
gactggtatt acgcgatgca gagggtgagc cgcattgcca gcatcatcgg tgtttttgtg 660
ctggcggcga tgagctttgc tgttcactga 690
<210> 355
<211> 486
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(486)
<223> BLCPAMOF_01882
<400> 355
atggaaaaat gggatttata taatgcaaaa cgggaaaagt ctggaataac agtgtgccgt 60
ggagaaatca tacccaaagg gctgtatcat ttatctgtga gtgtatggat cgtcaaccag 120
caggggcagt atcttttatc acagcggcat ccgaaaaagc aataccctct ttattgggaa 180
tgtacgggtg gttctgtact ttccggggaa accagtttac aaggagcaat ccgagaggta 240
aaagaagaat taggaatact gcttactccc ggaagtgaaa aattgattta tcagagcaga 300
cgggaaaatg tgcaggattt ttacgatgtt tggctatttc ataaggatat aaagattgaa 360
gaaatgcgtt tacaggaaac agaagttgtg gatgttcaat gggtaaatcc agataagtta 420
tttgagatgt ttcgcctgaa acatctgcac cctctaatta cctatgtaga tcagctaata 480
ggctga 486
<210> 356
<211> 669
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(669)
<223> BLCPAMOF_01579
<400> 356
gtggaggaca tcttcttccg ctatgaggac accatgaccc actatagcgt ggacaagatg 60
gccgacgcgg cgggcgagga cgctgacgtg gagctgaagc agaacaggga ggacatcagc 120
ctccggctgg acggcgaaac gcgggacgac ctgtcggagc gctatcagga gtgggtgccg 180
gtgcagacgc cagagccgca ggagcggctg atattgaccc acgaaggggt agagcaaaaa 240
acgagtgaag agctcagacg tgaacgcgac gaattactga aacaagagct ggagatgatg 300
gacttccaac tcgcgaaaaa aagggacgac ctcccgagtt tggattggtg gctcgagcct 360
gcgagagagg aaacgccggg aatcgggctt gacgagtccc tgaaacagct ggcttcccga 420
tttgaggcca tcgctcccga ggaggataag ccacggcttt tcctgctgga aaccaccgtc 480
ccggatggca caaagtatac caatctgttg gagagtgacc tgcggagcta tgccgacctt 540
ggcgatgact gggaggacct gccggatacc cagggtgaga taaagctctg gataccggag 600
gacttggggc agcccaaaga aataagcatc tcaaaggaga gcctgagcag catcgacggc 660
attgcatga 669
<210> 357
<211> 1200
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1200)
<223> BLCPAMOF_02285
<400> 357
atgaagcatc aatctctctc caaagtcctc aagcgtctcg cctgcgtgct ggcggcgctg 60
gtcatcgcgc tggctgtcgc cgtgttcgcc ctctggcaca acgagctggc caccctctcg 120
tccctcaaaa agctctctga ccgcgacgaa gcccaccgtg acggtgcagt ttaccagctc 180
aacgtctcgg gcggctacta cttcgacgat ttcctggccc agggcggcgc atccactgac 240
tctgagctca tctctttcat cacccagagc atcaccaagg gcatcatccc catgaacatc 300
aagaccagca ccatcgcctg ctcggccttt accgcagaca cccagagcgg cgaccgggtc 360
tttggccgca actacgactt ctcggccacc aacaccgcca tcgtctacac gaaccccggt 420
aagggtcgtc acgcctccta ctccaccatc gacctgagct tcctcggcct cgacaaggac 480
aaggatgtag agagcctcgg ccagaaaatc ctgaccctcg cggcccccta tgtgccgttg 540
gacggcgtca acgacgccgg tgtggcctgc ggcatcttca tgtcctatca gggcgagggc 600
aaaggcaccc ccaccgacac ccagaccgac aagcccgacc tcacctccac caccctgctc 660
cggctcatcc tcgactacgc cgactcggtg gaggacgctg tggcgctggc ccagcagtac 720
gaccttcacg actcggcaag cagctgcttc cactacatgg tggccgactc caccggccgc 780
agcgccgtcc tcgagtgggt aggtgctgat gccgaccacg acgccgacgg ctctcagcgt 840
cagctgaacg tcctctggaa cgacaccgac gccctctccg attcctccga ctggcaggtg 900
gtgaccaact ttatcaagac ctccggctac tacgacggta ctaccgtcga gatgaagggc 960
cttgaccgct acgagcacct tgcggctgcc ctgcgccaga ccaacggcgt cgtggctgac 1020
aagaacgctg ccatggacct gctggcttcg gtgggccgcc gcacctggaa caacgacgac 1080
tccaacagca acaccgtcca cagcgtggtc tacgatctga ctgataagtc tgttctctgg 1140
gtaggcaatg agcactacgg cgaggatggg tatacatttg agtttcagct tggggcgtaa 1200
<210> 358
<211> 759
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(759)
<223> BLCPAMOF_02496
<400> 358
atggtaacag ggattgaaag ctttaaggaa tggttcaagg gtaacgaaag ccagtatgca 60
attatcggtg gaactgcgtg tgacatcttg atgacggaag aaggcttaga cttccgtgca 120
acaaaagaca ttgaccttgt tctaattatt gaagccgtgg atgcggcttt tggaagaaaa 180
ttctgggact atgtaaaaca ggctggatac gaacattgta ataaaagctc tggtatgccg 240
cagttttatc ggttcagtca cccgatgtca aaccgttatc cagcgatgat cgaactgttc 300
actagaaaac tggatgcaat tcaacttcca gatgatgcag tattgacacc gctgccaatg 360
gatgaggaca tatctagctt gtctgcaatc cttttggatg atgattacta tgagttcttg 420
aagcagggga aagtgactgt tgatggagtg acggttttgg atgctgcata tttgattcca 480
ttcaaggcga aagcatggat ggatttgacg gatcgcaaag aagctggaga acacgttgat 540
agtaaaaaca ttaagaagca taaaaatgac gtttttcgat tgactgaatt gattgaccct 600
acggtcaaga ttgccactcc cagtggcgtg tatgaggata tgcagaagtt tgttgatcga 660
atgaaaaatg aaacggttga tgttaaacag ttggggcttg tgggacgaac gaaagaacag 720
attcttcagg agataggaga attatatgct atacaataa 759
<210> 359
<211> 1530
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1530)
<223> BLCPAMOF_00204
<400> 359
atggatttta gtctgcttct ttccagctat gctactgtct ggtccaaccc cgaggtcctt 60
ctgatgacct tcatcggcgc actgggcggc gttctgctgg gcgctatccc gggcatgacc 120
gccaccatgg gcgtggcgct gctcatcccc ttctccttcg gcatggacct catcccgtcc 180
atcggcctgc tgctgggcat ctactgcggc ggtatgtacg gcggttccat ttccgctatc 240
ctcatccacg cccccggcac gcccgccgca gccgccaccc tgctggacgg ctaccccatg 300
tgtaagaaag gtcaggccgg caaggctctg tccgtcgcta tgttcgcatc cttctgcggc 360
ggcgtcatcg gcgcactggt catgaccttc ctgtctccgc tggtcgctga tatggccatg 420
aacttcggcc ccggcgagat gttcatgctg gccgtcttcg gcctgtcggt catcgtcgca 480
atttccggca agtctgtggc caagggcctc atcagcgcct tcttcggtat gctgctctgc 540
accgtcggcc tcgaccccac caacggcatc ccccgcttca tcaccaccaa gcagaccggc 600
ctgctggatg gcttccagtt catccccact ctgatcggtc tgttcgctgt ctctgaagtc 660
atcgccggcg ttgagcgcat tatccgcggc gaagagcatg agcagaagtc caacgagaag 720
atcaccaacg tcctgcccga ttggaagacc atcaagaaga tctggcccaa catcctctcc 780
ggcggcctca tcggcacctt catcggcgcc atccccggcg caggcggtga catcgccgtc 840
ttcgtttcct acggcgccag caagtccgcc agcaagcacc ccgagctgta cggcaccggc 900
atccccaacg gcgttgctgc taccgagtcc gccaacaacg gctgctccgg cggcgctatg 960
atccccctgc tgtctctggg cgtccccggt gactccgtca ccgccatcct gctgggtgcc 1020
ttcatcatga agggcatcac ccccggcccc atgatgtacg tcaccgagct gcctaccgtc 1080
taccgcgtgt tcgcagctct gatgctggca aacctctgca tgctggtcgt cggctgcctc 1140
ggcgtccgct tctttgcaaa gatcgtctcc gtcgagaaga agatgctcta ccccatcatc 1200
ctcgtcatct ccctgctggg tgctttctcc atcaacaaga atgcctttga cgtgggcgtc 1260
tgtgtcgcct tcggcatcat cggctggctg atgaacaagt acgagttccc gctttctccc 1320
atcctgctgg ccctcattct gggacccatg tgcgagaaga acttcgtgcg ttacatgaac 1380
atccagcgcg gcaacttctt cgccatcacc acttctccca tcgcaatggt ctttgcaacg 1440
gtcgctatcc tggtcatcgt ctactctgtc tacaaccaga gcaagatcaa caagcgcacc 1500
gctgcaaacg ctgcacagga gaaggcataa 1530
<210> 360
<211> 537
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(537)
<223> BLCPAMOF_00203
<400> 360
ttgaacaaag acaaaatgaa aacgatggcc ttctccaatc tggtaggctc catcattttc 60
ctcgcgatcg gtatctgggc gtggttccag accgataatt tccctgaggt ggccaacacc 120
tatgtgcagg cttccacctt cccccgcgtc atgatcgtgg gtatgctcat cttctcggtg 180
gtcctgctca tccagtccat cttcaagctg atgggtacca tgaagcccac cgaccccgtt 240
gctgtcgaag tcggcactct gaatcccctc aaggataagg gcgtggccgc tgcttacctc 300
gtcatgctcc tctgtgtgct gttcgctgct ctgttcaaga gctgcggcta catcctgtgc 360
gctgtggtgc tctcgatgat catcatgttc ctcatcggca agcgcaactg ggtgcagatg 420
gtccttgtga gcgttctggt gccgctgctg atgtggctgg tgttctacaa ggtgcttacc 480
gtcaatattc cgctgggtcc gctgaacttc ctgcgcaccc tcgtggacat gatataa 537
<210> 361
<211> 1047
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1047)
<223> BLCPAMOF_00202
<400> 361
atgaaaaaga tctctcgtcg tgacttcctc gcagcttctg ctgctgtggg tgcagctggc 60
gtcctgaccg cctgcggcgg ttcttccagc agcactgcca cctctactgc agcttccact 120
gctgccagca ccgctgccgg cggcaagtct accgactacc ccaccaaggg tatttccgtc 180
atctgcccct ggtctgcagg cggcggcacg gactcctgcc tgcgcgcatt ctgcgaggct 240
atgggcaaga acctgggcgt caccctgact gtcgataacc agactggcgg cggcggcatc 300
ctgggccatc aggctatcgc agacgccaac accgacggct acaccatcgg tatgatcacc 360
ttcgagctgg ctacctataa gaagctgggc accagtgaac tgacctggga gaattacgct 420
cccctgtgcc gcgtcaacac cgacgcagct gccatcaccg tcggcgcaaa gtgggctgca 480
gacaacggca tcaccgacct gcccggtttc attgattact gcaaggctca ccccggtgag 540
gtgcagatgg gcggttcttc caacgcttct gtctggcaca tcgctggcgg ctacctgatg 600
agcgctaccg gcatcgacat ccagatgatc acctatcagg aaggcgctgc taccgctgtc 660
cagaacgcag ccggcggctt cattcagggt gttaccgtct ctctggccga agctcgcagc 720
ttcatcgagt ccggcgacct gatctgcctg ggcgtcatgg acgaagagcg caaccccgtc 780
ttccccgatg ttcctacctg caaggagcag ggctacgaca tcacctacta cacccagcgc 840
ggtatggccg ctcctctggg cgttgatgat gccatcatga cccgtctgga agaggcctgc 900
gccgctgcca tcgaggaccc tgacttcgtg accttcatga acaacaacgg tcaggcaatc 960
tcctatctgg atgcacaggg ctatgctgac tacctgaagc aggctgctgt cgatgtcgca 1020
gctgctatgg acgctgtcgg cctctga 1047
<210> 362
<211> 225
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(225)
<223> BLCPAMOF_02493
<400> 362
atgaacatct ttgaagaaaa gaccgacagc gaactgcttt cctatttttc tgattatcaa 60
aagctgtgtt cccttgacaa atatactgga tttcaaaatc cagactttac ggctattctt 120
aaatcctatc gggagaagtt cggccctatt ggtgaaggag tccttggtca cgacttcttt 180
gaagctgttt tccatcgttg ggaaaagacc gtacataacg actaa 225
<210> 363
<211> 393
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(393)
<223> BLCPAMOF_02825
<400> 363
atgagctttc cgcaggttct gaccggtgtg gcgcacattg gcatcccaac aaatgatctc 60
gacaagacca ttgcatttta caagaagctg gggtttgttt ctgcgctgga aacggtaaac 120
aaagccgccg gagagcgcgt tgcgtttctt cagcttggcg atctgatgat cgaaacttat 180
gaaaaccatc gtgcggcgga aaaggccgga gcaatcgacc atgtagctct ggcaacgacc 240
gatatcgaag ccgcctttgc tgcagcaaaa gaggcaggga tgcacctgct gcattccagc 300
atccagtcac tgccgttctg ggaaaacggt gtgcgctttt tcatggtcga aggcccgaat 360
aaagagagaa tagagttctg ccagaaatta taa 393
<210> 364
<211> 540
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(540)
<223> BLCPAMOF_02752
<400> 364
atgttgagta atatgaatcg tcgtaaattc ctgaagctca ctggcaccgt ggtgctggcg 60
acatctgttg cgggagcact gggcggatgt agtggtggcg gtagcagcgc acctacaccg 120
ccctctcctg aagaagagag aatagcgcaa attatcctgg attcgatcaa tgctgcacgc 180
aaagaagttg gattggacgg cacagttcaa gaagtggata aaataagcca gctttcagca 240
cagcgtgcgc tggaaatgat gaacggaaaa aagcacgacg agctttcacc agttccgcag 300
gagttcaaag acggcggaaa aggctacaag tatggtggaa gggaaaattg gacagtaaca 360
ggacttccgc gagaccactt cacgaaaaat cagctgacag aatacttccg aaacaatttt 420
cagacggaac tgaatacacc cggtaagacg acgattcggg aagatgtata tgtaggaatc 480
agtgtgcagg aacagggtga ctatgtgtgg tatgatataa tctttgcaca cgagggatga 540
<210> 365
<211> 360
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(360)
<223> BLCPAMOF_02713
<400> 365
atggcaagca agaaagtcga aatgtatgct aaaaaacgat atgaattaga tgaaatcaaa 60
aataaaatca aagaagaatt tgataaacgt aagttctccg atgtggaatt caaagacgaa 120
attatacgtg aattgggaga caccaaaaca ctactattaa tttttgaaaa ctggttttta 180
cgaacaggaa gttatgccag tttagtaatt atgttatccg agtatcaggg gtatcagagt 240
gcagatatta ttgccactgg tggtaaagaa gctttctttt cttttggtgc agaaggtgac 300
tttgcaaagt ttggagaaga tgctttggag aatttaggct ttcaaggaaa agttagataa 360
<210> 366
<211> 1161
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1161)
<223> BLCPAMOF_02056
<400> 366
atgaatacta tgatgacttt agaacaactg cctcccaagg gtgtaaagcg agaacaggcc 60
attttggcgc tgggcaaaga ggaagcaaac ggcgaactgc ttctccagct tgtgaataca 120
gaaaagggca agtgcaaaac ggctgctcaa aaggctttgg cgcagctgga gtatgcccct 180
gctgccccac tgtgggccaa gctggtcaag ggcaaatgga tgggcagcca tatcatgtcg 240
gatgcctgct cggattgtgt atcggagcag attgccccag tcatcctgaa aaccctctcc 300
ctgctgttgg atgaggcgga tacaaaaccg ctggaagagg gacaggtgga acagatgaat 360
ttctgttttc atttgatgct gggcaaagcc tcccccaaga tgttggaggt gtaccgtttt 420
ctggcggaaa atgcggaacg gatcggccat ctcaagcaca ccccctttta tgatggtgac 480
aaatgcacta catggcacat ttcccaagga ctggggctct ataaagtaaa gccaaaggaa 540
atggagaaga ttccggcttt gattctgacc gcctccttga ttcgaaaccc ggatacacga 600
ctacaagcac tggccgatga actatatgaa cgctatggcg gcagttggct gattccagtc 660
tttatgaaag caattatcac ccagcccaag gaacaggtgt atgaaaccta ttcgctcctg 720
ctgggcactc ccaaagaaat ctacctgttc aatgctctgg ggatgctgga ttaccgctgt 780
tatccggagg actggatcta tgaacgcctg gggcctgatg gaatgactgc gttcatcttt 840
tggggccatg accgctacgg gtcctatgac acgaccttta tgtttgaacg ctatgtggag 900
ctggatgagc ggtggctttt tgatctggcc aaagaccctg aaggtcgaaa gcctacggtg 960
acttggcaaa gttacaaccg gagtggtgtt ttgtacgaaa gctacgacga aatgttcatc 1020
agtctgctgc cccgcaaggt ggaaaacccg gaactgaagt gcgttctgcg ggactacttc 1080
cgcatccgca gccagaaaaa gaaagtggct aagagcatca ccgtttacca ggatgctgcg 1140
gaacggttcg gagatgaatg a 1161
<210> 367
<211> 1128
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1128)
<223> BLCPAMOF_02823
<400> 367
atgaccggca gcggagcaaa taaccgcgat gttaaaaaaa tcaaccgcat ccgaacgatt 60
cgcagcattt tttcctgcga ccgaatctcg cagccggagc ttgcggcaaa agtcaacaac 120
agctggccga ccgtattgca gaatgtcaaa gaactgatgg cgatgggact ggtgcaggag 180
gtcggcacct ttgaatccac cggcgggcgc aaggcgagag cattcgctcc tgtacgggat 240
gccagacttg cggtcggact ggagattacc cagaatcatg tcggagcagt tctggtcgat 300
ctgtccggta accttctccg ctatgagcgt aaaaagcgtc tttatgagcg gtcggacacc 360
tatgcggaaa tgcttgccgg aatcgtgcag gggctgatcg aaaaagaggg ctacccggtg 420
gaaaaaattc tgggtgtcgg catttcgctg cccggtattc tggacaaaga ggggcagaca 480
ttggtttact ctcatgcctt gggtctgcgg aatgttccta ccgaagaatt cagccgttac 540
atcccgttct cctgccggtt catcaatgac gcgaacgctg ccggacttgc tgaagtgcgc 600
gacctcgaat ctccccgcag ccttgtctac ctttctctga gcaacagtgt cggtggtgcg 660
attctgaccg gtggagcgct ctatggcggc gaccatcttc gtgccggaga gttcgggcac 720
aacacgctcg ttcccgatgg ccgcccctgc tactgcggaa aaaagggctg tctggatgcc 780
tattgctctg caaaagtcct ctcccgactg actgacggaa atcttgcact attctttgat 840
gggttgcgct ctggcgatgc agctttgcaa acggcatgga atgaatacct ttcttacctt 900
gctgtagcag tcaataatct gcgcatgacc ttcgactgtg atgtaattgt tggcggctac 960
gttggcggat ttctggcaga gtttggcgaa ccgctccggg aaatgctggt cgagcgtaat 1020
acgtttgagc cggacagttc ctacctgaag ttcagccgct ataagctgga agcctctgcg 1080
ctgggagccg ctctgctcca tatcgaagcc ttcattcaga acctataa 1128
<210> 368
<211> 651
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(651)
<223> BLCPAMOF_01871
<400> 368
atgagtaata ttttgaaatc cacaaaatta gatattgcat tggtaaaacc atattttaag 60
acgatttgct ttaccctgct tctgccgatt gtgtttgccg caatcaaccg ttctttgctg 120
acaggggtat catttgccat gtgctttatt gctatgacga cgggatatac cttttccatc 180
acagaaaaaa acagcatgga tcggctgttt ggtattttac ctgttcggaa aagcgagctt 240
gtgatcggac gctatgtttt cgtccttgca atggggcttc tttccttgat tatttctttg 300
attgcacagc cgcttgtctt gaaagtgctg ggtgaaacag ttggcgtatt tgacattgta 360
actgccgcta ttgcaggagt attcttattt gcactctata ccgtgttcca gattccggga 420
tattacaagt acggttcaat caaaggacgg gtatttatgt atattccagt ggccggtttt 480
ttggtgactt tacttcttct ctctaaaatg ccagccatcg ggaaatcaat tatttcagtc 540
gttgaatctt ctccgatact tctcgttttc cttgcggttt ttgctattgt cgtgatgtat 600
gcggtttcga tcttcttgtc cattcggatt atgaagaaca aagaaatgtg a 651
<210> 369
<211> 114
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(114)
<223> BLCPAMOF_01870
<400> 369
atggatttca caattttggc agttgtgctt ttgcttggtg ttggcgttcc tatccgtaat 60
aaactcatac ggaaatatcg ggataagaaa aagaatgatc gcaattcgga gtga 114
<210> 370
<211> 837
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(837)
<223> BLCPAMOF_02653
<400> 370
atgtcagtac aaacagattt cgagaaagaa tttgaaacag aagaatatga aatgcttatt 60
ttagtacaag catcatgtgg gggagcagta tgtataaaag atatgctgaa accatcagtt 120
gattttcttg catccataga tttgcgcaat ggtcagtttt ttcatgagaa aggccgtgtt 180
gaatggctta taaaaaaaga taataaacgt aaggggtggg gatatgattt tgagcaattt 240
ggtatttatc gtgtcgttgt taggaaatgc atacctcaaa aattacaacc atatcaatta 300
cattatatga acaacagata tatgctaata agagtactgg aagaaaatgc ttcaaacgaa 360
aaattggaag ccttgaagga acattattca aaacctattt ctacggaaaa tgaattaggt 420
acttttgttt tggacagaga gttttcatgg tttgaaggaa gtataaattg gaatggtgta 480
gaggcaaatg tatatttgga aacagacgaa gaagatggag atactgctga acaggcaatg 540
gctgtcctaa aaagtgtaat tgagaatatt gtggataacg ataataagta tcgtgagttt 600
gcggcacaag aacttacagg acttgcaaat gagtggttga gtgaatcaga tgaaagcgat 660
gtagaagaaa ttacacaaga aacatttgct aaacgtatgg aaattagtga agtaacagtt 720
agtcccgatg gaagcttgtc attaatttat catgatgatg atatgttttg ggggcatatt 780
attgaaatag tggttgagcc aaatggagag attataagtg ctaatatagc cggatga 837
<210> 371
<211> 498
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(498)
<223> BLCPAMOF_02107
<400> 371
ttgagcagcc tgggcaatct gttcggcctg ccttatgtgg tcatgcgtaa accggccccc 60
attgatacga cgactctgaa ctataattgg cagatctggg agaccaatgc gttcagcatt 120
tataccaagg aaacggacga agttggcgag cagagcgcac aggaagccgt tgctgccgtg 180
ctgcggtatc tcagccgggt cggtttactg cgataccact gccacagcgg gtatctgtcc 240
accgtcgtgc aggaaaacga gatggcaaat gtactcaccc cggcgggcgg gatcttccgc 300
cgcttcgtgg agccgggaca ggaagtggag tatggtcaga aaatgggcgt gatccttgat 360
ccgtttactg cggaggtgga agcagagatc acctgtccga ccagtggtgt tgttttcttc 420
gctttgaaaa aaccgctgac aacagaacat gaggtcgcat ttaaggtgat ccggcggctg 480
catgggggat gtttgtaa 498
<210> 372
<211> 2025
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(2025)
<223> BLCPAMOF_01921
<400> 372
ttggcaggag tgcatgaaga tttcggcgaa aagatcggcg gtgcgaaaaa agacctgtgg 60
aaagaccgcg ggctgtatgc ggatgatctg gaagccatga atgagcgcga agccgaaaaa 120
tttgtgaaaa aggataatgt ctggaaaaag ccggactatg cagccatgct ggaggaaggg 180
attcctcttg gcgtggtcta ttttatcaaa aaagcgaggg acggcttaaa cgcttcccct 240
cagtattacc gcacggatga caccccggaa aaacggaccg cgagacaaaa ggaatatata 300
aaaacagtcc gggaattgca gacagtgctt tcagatgtcc gtactgtgga ggatgccata 360
agagcctatg accgcttttt cgctgacaat ggatacttag aaaaggtaca gggctgggga 420
agcggaatcc attaccgggc aacgaaaaag ggacaggaca atcccgtgat cacaaacaaa 480
ttgtccaata ccatgctgat ccgctcggct gaatattttg agcgcaactt tgctcagaaa 540
gcaaaaaagg aacagttttg tgtttccaaa gagcagaaaa taccgaaagg ttatgcgatc 600
cacttcaacg acgggaaaca gacctattct aaaaatgggg actggaaacc cggtacctac 660
tatgtgacaa aaggctattc gatcctgcgg accaattttg agaccaaaga agctgccctg 720
aaatgggtgc aggaacttgc caaaggcagg aacaaaaacg gaaagatccg ttttgtccct 780
ccacagcttg cccatgtcaa acgtaccgga ccggattatc ggaatggcgt ggagatcacc 840
ggacagcatt atcttgatac ctttgggttc cgcggcggtg agtttggaaa ctggatgaac 900
cagaacgacc ggcagacctc ccttaacatg ggatttgaag cactaaagga tctggcgtca 960
gcccttaaga tcagcgataa agatattgct tatcagggaa cacttgctat cgcttttggt 1020
gcaagaggca gtggcaatgc tgcagctcat tatgaacctt tgcgtacagt catcaatctt 1080
acaaaaatgc acggggccgg ttccctggca catgaatggt ggcatggact tgacgattat 1140
cttggtacaa agatgggagc aaaagggatg ctgtcagaac agccccacct ctatgcgccg 1200
ttccaaaaac tcattgacac catgaagtat aaaccggaaa caccggaaca ggcagcaaag 1260
cgcacggaag cacaaacaga acgcacccgg aaaaatgcgg caagctggct ggattcctcg 1320
gttcttgcct ccctgaaacg gtatggcaat gaggaacaga tggaaaccta cgcagtcttg 1380
cgggaagcat ttttgtccgg cgaacccggc tctgtggaac agatcagcgc atttaagaag 1440
aatgttaccg gccgggtaat tcccaaaagt gaacgggaac ggctggaaat ttttgagcgt 1500
atgctttccg ggatgcaggc gcaggaagct ccgcagattg gacggacgga aactgatttt 1560
taccgtaatt cggtacgcat gggaaaagaa tgtgaaaaag acggcggtta ttgggacagc 1620
aatgtggaaa tgacagccag agcctttgcc tgttatatca aggacaaact gccctacaca 1680
tcggattatc tggcaggcca tgccgactgt gcccttaccc tggtttccgg taaagacgga 1740
gaaatggagg tattgaaagc cttccctgtg ggggaagaac gccgtgcaat caacgctgtt 1800
tttgacgaga tcattcagga tttgaaacgg gaacagctat tgacccatgc cgatgtaacg 1860
cttcccctct ctgtttctga acttcgtgag gcggcggacg ggcagctatc catgttcggc 1920
gtcggccgtc cttccgtgat ggatcagctt gcggcaaaca ggccggcaga taaaaaatca 1980
ccggcacaga cgttttccag aaaaaaccac gagccggaaa tatag 2025
<210> 373
<211> 417
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(417)
<223> BLCPAMOF_01878
<400> 373
atgaaaaaaa tcaatttttg caaagcaaca acaatcatct taataatcaa tgttatttta 60
tctattgttt tatttttcgt tgttcctgat aaaatagcaa ttcaatgggt aggtacatcc 120
cccagcaatg cagtagattc ttactatgta tttttggtgc cggtattgtc agtgcttttt 180
gcttttacgg gaaaacctat ttttacaatg ttcctgttta gattgtggaa tagaactaac 240
gagcatttag tgacatactt aaatttgtgt ctgcaagttg tatttcttac ttgtgaaatc 300
tatatcggat tatataacct atgtaatttt aatgttgcca ttagtataat tctcattgtg 360
gaacttatga tagatgtggt gattggattg aaattatttc acaatcaatc tatctaa 417
<210> 374
<211> 1944
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1944)
<223> BLCPAMOF_00199
<400> 374
atgccggacg aaaagatgaa atatccactg ctggaattcg aatatgataa aaagctttat 60
gaggagcttt tgacgctgaa tccgcatccg gagtttatgg atagggtcag catcgtgaca 120
gaggattatg agcacgatga tttcgggagt cttcccggtg atgagaaaaa tgctctcggc 180
cacgcagcag gtgttttatg gaagattcaa aaatacggga cgtccttttc ggatgaagaa 240
agcaaaacca tccgaacgag aaaacgctca cgtacaaaaa agccagacct gttgttattc 300
gtaaacgatt tggaaaatga ttttcataat tactgtgctt gcatcaaaca tggcctcgga 360
aacaaagctg acctgtgtgc gctaacggag gctttgctct gttacggctg cgaagatact 420
gtatgggaag aagtcacaga atggcatacc gctgtgagcg agaataaaaa ctttgccaaa 480
tcaacatttc ttcccaactt tgacagactc tatatccgac aggcagaccg ttttttgttt 540
ctggagctca atactgagga agccctgaag ttttacgggc tggcaacaat gttgtgggac 600
catgagccgg acacaaaaga aacaaattcg gacgaccatt ttgtttcatt tacacgtcag 660
tatgaactct acagccgtat tttgaaaggt gcaagctatc cttatggcac atcctctcaa 720
ccatccgcat tttttcagtt gtataaccgt attattcact ccggaatttc gtcctcctct 780
ctttctgaaa agctgagtac cttcgtttta tccattcagg agataatgga gtctccatcg 840
tcccgaagcc tccatcgagc ccggcttgct ctgctgatgt ttatcgtcat aacaaaaaag 900
cattttatcc ctgagcttgc ccgtctttat gatgaccctg acagggagcg ctgggaagtc 960
gctatcatgg aaaaatcccg cctacttgag gataccggtt actctattct ttctcactat 1020
gcagcgcata tgacatggaa gtcggggaca cggtacttcg actcttatct gaggctggca 1080
aaagctgcat atctttcgga acttcttttg gatgaactga acgctgaggg ggatgcggcg 1140
gaaatcgctt attatacatc ggcagaagtt ttttcttata tgctccccga aaaatgcaca 1200
aaagaggagg ggaaagaagg gcgtctgggc aaattgaccg ttatgcatct gtcctatatg 1260
aatgacccaa acgaaggtaa aactctgcaa aaggcaattt acggcccatc gtatggagca 1320
cttcaaaaag gccgcaaacc tctggatgtt ccctttgtat ttgtaaaatg cttcagcccc 1380
cgcatcgact acctgcccat gtgggaaatg tatggcgacc acgccagagg ctgctgtctt 1440
gtcatcgact gggaaacatc aaaatggatg gaagaagaag ccgagcctgt tctctatcac 1500
gtctgttacc ttcggaaaca gggaaattcg tatgtagtct tgaacgaaga caatgaaaag 1560
ctttcccgct cctgccgcgc cataaattca cagctccagg aactgcacaa tgtcgccgag 1620
gaaatcgcag aacaggaccg ccgttatctc gatgatgtcc tagggaaagt cctctacctc 1680
ttcaaagaca gcagctacag ctacgagcaa gagctgcggg tcatctacca gacgaaggac 1740
aacatcctcc atactgacgg cgacagaccg tggcttttcg tgcagacacc ttttcctctc 1800
caattagacg aagtcattct gggcccgaag ttcccggacg tcagcacccg ggtgccttac 1860
ctgcaggagc agctcgacct gatgtgcgaa aagaccggca cggaaaagcc acgcatcacc 1920
ctttctgaaa tcgactaccg ttga 1944
<210> 375
<211> 135
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(135)
<223> BLCPAMOF_00872
<400> 375
atgaaaacaa acgcaccttc tttgattttt ggcgcggctg ctttaataaa agaaacgaaa 60
ggagatagag tgaaaacgaa cgataccttt acgcttcagg ataagactct gctcagaaag 120
gaggcaaagc gatga 135
<210> 376
<211> 468
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(468)
<223> BLCPAMOF_02577
<400> 376
atgctctccc tttacttttg cagggcagtc cgtgtggatt gtcctgcttc ttatatgagg 60
agaagacaga ttatagaagg gattaccttc agggtggacg gacaggaaaa gcttgccaat 120
cctgttaata cgatgatgtg ctttgaagaa gcattaaaag accatgcata tatcttgaaa 180
atgattgagg cacggatttt agtggagcac ggattgctga aggaatacaa ttttgacaca 240
gcaaaaatcg atacgcgccg agagaacatc aagagtgtat ttgattcagt atgtaatcga 300
aaacacacag atcaggaaat tcagaaggca tatgaagaag tattaaacgt agatattgaa 360
gggattcaag taaatccctt caaggcactt tactctgtct actccagggg tatcgccgca 420
acaacaatcc ccaaaagaag cggctggggg atggcatcct ctctctga 468
<210> 377
<211> 1089
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1089)
<223> BLCPAMOF_02574
<400> 377
atgaaaaaga tttctcgtcg ttcgttcctg atggctaccg gtgttatcgc agcttctgct 60
gctctgagcg cttgcggcgg ctcctccgcc agcacctctt ctgccggttc taccgctgct 120
tccactgccg cttctggtac tgctgcacag ggcggcggcg acctcgtgat ctactcgccc 180
aactctgagg gcctgctgaa cgccaccatt cctctgtttg aggaaaaata cggcgtcaat 240
gtcgagctga tccaggccgg caccggcgaa ctggtcaagc gtatccagtc cgaaaagaac 300
gatccctacg cagatgtcct gttcggcggc tcttggtcgc tgatgtacac caacgaggat 360
ctgtgggagc cgtatgtttc cgccaatgat gcaaacgtca tagatgctta caaaaacaag 420
tgcggcttca tcaccggcaa cgtgctggac ggcagtgtcc tcatcgtcaa caccgacctc 480
atcggcgaca tcaagatcga gggctacgaa gatctgctga acccggctct gaagggcaag 540
atcgccactg ccgaccccgc caactcctct tccgctttcg ctcacctgac caatatgctg 600
cttgcaatgg gcggctacga ggacgataag gcatggcagt acgtccacga cctgtttgag 660
aatgtggacg gcaagatctg cgaaagctcc agcggcgttt acaagggagt tgccgatggc 720
gagtatgtgg tgggtctgtc ctatgaggat ccctgtgctc agctggttct ggacggcgca 780
cctgtcaaga tcgtttacat gaaggaaggt actgtcttcc ttcctgcttc cgccaccatc 840
atcaagggcg caaagaacat ggacaatgcc aagctgttca ttgacttcat cctgagcgag 900
gaagtccaga acatctgggg cagcaccctg accaaccgtc ctgttatgaa ggacgctgcc 960
accaacgatg ccatgacccc gatggcagac atcaatgtca tcgaagagga cattccctac 1020
gtcagcgccc acaagtcaga gctggtggac aagtacactg agatcttcac cgatctgcag 1080
agcaagtaa 1089
<210> 378
<211> 336
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(336)
<223> BLCPAMOF_02479
<400> 378
atggaggtag atgaaacata tcaaaaaatg ttagaaaagc tgagagagca ttgcgaaaga 60
gaaaaaatgt cgatatatgc gttggcaaaa aatacaaatt tgtcaacttc cagcttaagc 120
aatttactta acggaaaaac aaaaccatat gtatacacgc tattactgat ctgtgatgcg 180
ctttcaattt caatcacaga tttggctgat aaggatgtat caatgacaga agatgaaaaa 240
tggataatat cttcttatcg aagtttgtca actaagaaga aagaaatgtt gacaacctac 300
ataaagatgc tgtcacagta tgaagaaaaa atgtag 336
<210> 379
<211> 1314
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1314)
<223> BLCPAMOF_02474
<400> 379
atgaattttc taagaaccac aaaattgagg caggggaaaa cggtgaggaa cattaaatct 60
tctttagtaa taccacgact atcagttgtg gaaaatatta cgtttatact atcgatactg 120
ttgctgttta tgcaaccgct aaaaaatgct atttctatct tttcatatat tgatgaattt 180
gcagttctat tttcgtttat ggcatttgct tatactgtaa ttaggaggcg ttctataagt 240
actatagaag gaaagataat tgcttccttt ttgttgttta tcatagtcgg tttatttggc 300
aatactttat caaaggtcga tagaagcaca gcggcaatcc taacagatgt attgagctat 360
ggaaaattct ttatgatgat aatcggtgga gtggcattat tcgattcctt gaaaaattct 420
aagtggatat tttctattat tgttaaatta gttagatgct tggttgtggt ggggctaata 480
cttgctattt tgaatcaaat tattgatctt ggtatgagag atgatataag atacggtatg 540
tattgttttt cgtacatcta tgataccgca gctattttta gctggtattg ttacatgttt 600
atccttgttc tttctattga tctcttaaat ggagttaatc gaaaaagaat tatatttgtg 660
ctattaaaca tgtgcctttg gctatttacc ggacgcagta gaggattcgc tttttgcgct 720
atttacatta tgcttgtctt attactgcgt atgtatgaaa taaaacaaaa gcaattaaaa 780
ataaaaatag gatattttgt tatgctaggc ttgcttggcg ttatagttgc atggaaccaa 840
ttggtttttt attttactac aacaacagaa gcgagaagta tattattgta cgttggtatt 900
gatctattta aaaagtattt tccattaggt gcgggtcttg caaccttcgg tacagctgcc 960
gcacaaaaat attattcgcc agtatatgga atatatggat tgagtaatcg acatggcttc 1020
acatttgata atccactgta tttaactgat aatttttggc ctgctgttat tggggaaacc 1080
ggtttgattg gtttggtcgt ttttcttgtg actttgtatt ttgcctttaa atatctatat 1140
aaaaaatgca accaaaccaa tatgtctaga atgattatta ttttctttat agtgacaatt 1200
ctctcatcaa gtattgcgac atctatattt gcacaaaatg caacagttgc ggatattttt 1260
tatatatgca tgataccagc tattttgcga agggaaagaa tcatttatgg ataa 1314
<210> 380
<211> 228
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(228)
<223> BLCPAMOF_00773
<400> 380
atggtatttc gtatgatttc gtttgagccg ctttggaaga cgatgaagaa aaaaggtatc 60
tcgcagtata aactcatcaa agaatacaaa atcagcacag gccagttgga caggctgcgc 120
aaaaacggga atgtcagcac ctacaccctc gaccagctct gccgcattct ggactgtggg 180
ctggaagatg tggccaccta ccaccctgac acggaggtaa agccgtaa 228
<210> 381
<211> 654
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(654)
<223> BLCPAMOF_00079
<400> 381
atgaagctgt atcagaaact tatttctctg ctggtggctg cagtgatggc tgccgtgctg 60
atgccggtgt gcatggctgc tcccggcgac tccgttgaga cccgcatcaa caacgcgctc 120
gcacagcgca ccggcgcaga gctgtatcag gagatcgtca ccactgcccc cgatggcacc 180
acccagacca tgatcgcagc ccgcagcaac ggcaacgctt atatcaagat ggatatgggc 240
gacgccggca gtctggtcta tatcctgaaa gacggtcagg gctatctggt ggacgatgca 300
tccaagatgg ccgtcagagg cgaagtaccc actgtgagca caagcgagat agtctccgct 360
gacgaaggcg aagcacagga gatcccctgc accgtgacca ccgtgaatgt gaacggtcag 420
gactgcgagg ccctgtccta cactgccacc gatgccaacg gccagacggc caccgtttcc 480
tactgcctgg tcggtgatga cctcaagtat gtcgttaccg atgctgccga gggccgcacc 540
atcgtggagt accgcgtcac gagcaccact gtggaccaga atctcttcaa catccctgcg 600
gattatcaga tcctgacgca ggcagagttt gaagcggcac aggccaacca ctga 654
<210> 382
<211> 912
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(912)
<223> BLCPAMOF_02471
<400> 382
atgtcgaaat tacttatagc atcaaagaat agtattaaat atttcattag caaatgcacg 60
gattttgttt atttacagag gtggaaaata gcgacacaac acccttgtaa gttgctgaat 120
aagcaaaaaa gaaaagaaga aataattgta agcttaacat catttcctgg aagaattcat 180
ttggtgcaca aaacgataca aactattttg ttgcaatctg taaaacctga tttggttgaa 240
ttgtggttgg ctaaagaaca atttccaaat tatgaaaaag acttaccaaa tgaattaaca 300
aatttaattc aatatggatt aaaaatttgc tggtgcagcg attatcgttc atttaaaaaa 360
cttgttcctt cattgcaaga acatccggat gctataatcg ttacagcaga tgatgatgtt 420
tattatgcaa aagattggtt agaacgattg tatagtgcct atttagaaga taataatagt 480
attcactgtc ataaagcgac taaatttagt tacgaaaaag gaaaatttaa tgcaataggt 540
ggagggaaaa aatattatca taaagcatct tttttgaata aactggttgg tgtaggtggg 600
gtattatatc cggccaattc attagatggt gaagtcgtaa attcagaatt atttaataga 660
cttgcaccta ctaatgatga tatttggttc tggtttatgg caattaaagc agggacacga 720
ataaatgttg taaaaggtaa tcatcccaaa cctgtggatg cttatggaag ccagtctact 780
attaagttaa cagatattaa tgacaatggc gatatgttgt tctggtctca attcaatgat 840
cttataagct attaccctga gataagaaat gcattgattt cagagatgaa acagaactat 900
gtaagaggtt aa 912
<210> 383
<211> 273
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(273)
<223> BLCPAMOF_00714
<400> 383
atggacgaaa acgaaaagaa agagccggag atgacacagg aaccgcctag gcccgaggac 60
tacagccgtt acatggggac cctgaaccgc atctaccgcc ggaacaataa cccgcagcgc 120
aaaaagctgg gcgacggcat cacttcgctg aaaaaggggc agcagtctgc cgcccctgcg 180
ccggagccgg gcaaaaaaga ccgcagcttc cttgctgtgg cgggcggagc catcgttctg 240
atggcgatcc tgtattttat caagctctta taa 273
<210> 384
<211> 1308
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1308)
<223> BLCPAMOF_01710
<400> 384
gtgaaaataa aagctttgtc ctttgtcctc atggcggtgc tgcttttgtg cggctgtggg 60
cagaagagcg aaacggcggc tgcgaccccg gctcaggcgg tcacagcgtc tgctgcccag 120
agcagtacgg ttcgtccggt gagtaccggc gttacgccgg aacagttcgg ggcgaagggc 180
gacggtatcg cggacgacct gcaggctctg caggccgcga tgcagcaggc cagcgcgtcc 240
ggtcggcctc tcgagctgac ggcgggggcg gtctaccgct tctcctcctg cctcgggctg 300
cccagcggac tgaccatcca gggaaacggc gctgtcctgc tcagtgatat tcagtaccct 360
gacctgagag aggaccgtgt ggcggtggag cttatgaaag actctgatga tgaccgcgcc 420
cacgacgtcc ggctggaaaa tgtgaccttc cgggcagcgg acagctgtca ggccaactat 480
atgctccggg tgatgctcgc ccgcaatgtg gaatttgtgg gctgcacctt cgactgtgag 540
cccaacgagt gggggcgctg cgccgccgac ctgtatggcg gcaacgagaa tatccgtttt 600
gagggctgtg tgttccgcca gatgacctcc ggcgcgtccg gcggcatctg ggtgcgcaac 660
tggacggaca gggtggagag ccggaatatc cgcttccaga actgtgaatt ttacaagtcc 720
ggtgccgacg agctgctggc ggtctgggga tggggcggcg cggtgcggga tgtcgtcctc 780
tcgggctgca gcttctatga gacacagaca caggagggac tggatgccga tcatcgcccg 840
gtgtggttca tcacgctggg gcagagcggc accacagacg tccggatgga ggattgcacc 900
gtccgtgcgg agtattgcga gaccattttc cgtatggtag gcgataagac ccgcgccgtc 960
gtggacaact gcgacatcac catgagacag ccggacagca tggcaaagca cgatatgaaa 1020
aagggcgcga accccatgct ggcccggggc aatgaccgtg ccgacggcag cacggtcatc 1080
cagaacagcc gcatcaccct gagcggcgac aacgggcggc gcatctgcta tcagctcagc 1140
gccttgaaag gaaatacgct ggacgtctcc ctcggctacg gcatcgccag cacgaaggaa 1200
gtcagcggca acaccatccg gggccggata cggcataaag tctttcagga ctgctccggc 1260
gtggagaata acaatgtaga agtgcggaga ttctcgattc tgggatga 1308
<210> 385
<211> 1425
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1425)
<223> BLCPAMOF_02497
<400> 385
atggaaaaga aataccaaat ttttatttcg tcaacttata aggatttgat agaagcacgt 60
agcaaagtaa gggatgcaat cctgtcaatg atgcatttcc cagttggcat ggagatgttt 120
aacgctgctg acgaagaaca gtgggaaatc atacaagaga cgattgatag ttcggattat 180
tatgttttga ttttgggaca gcgatatggc tctgtaatag aatctggatc ggatgctgga 240
attagctata cggaaaagga atttcgctat gcgagagaga agaaaattcc tattctggta 300
ttcataattg atgatgatgt ggcaattaag ccggaattta tggaaaaaga tccagaaagt 360
ataaaaaagc tggctgattt caagacagaa gctaaaaaag gacgaacggt acagtggtgg 420
actaatattg acgaacttgc tagagaggtt tcagaatctt tacatcagca aatggatcga 480
aaaaagcgtc cagggtggat aagaggagat gcctttgata ttgaagcaag tcatgcggaa 540
attctcagtt tgaataaaaa gataagagaa cttgagcagg aaaatgctga gctgaaatca 600
cagattgtaa agagggttcc tgagttgatg gccgcagttg tgctggatca acaggaggat 660
gaagaggagg atgaaaaagg tcttaaaaca catggaaaat tgcttattga tagctctgat 720
aatgcataca aaatccaatt atatcataat gatggagaat gctacaaaaa caagtatgaa 780
ccacttgatt taagttgcgt tgaatcacat ttaaaaaagt atgtaaaaga aaaggacttg 840
caggcttaca atgcagcact accgtctgaa gaagaaataa atgattatgc acacaagatg 900
agcgtatata agacaataac aaacggtggt gttgcgctca agctaagagt gcttaataag 960
ggaacagcga aagcaaccga cattagaatc tcaatcgtat ttccaaaaga tatttttgta 1020
tatgacattg atgatatcga aaaaatgaag gagccgaaag caccaaaact tccaccgaat 1080
cctattgaaa aggcagagga acgttttatg agcgacttaa atccagtata tggcttgttg 1140
aaaaatagta tggacggaat gcagccattc tactcagctc gaagcttgcc gattatagac 1200
ccggcaattt ttaacaactc caattcttct gtgtttgaat caatatctat acgagataac 1260
tcaatatttg ctgaatgcaa tcagttgcca cataaagatg ataccgagtt tgatgggata 1320
tatattgttc cggctagaaa aggaaaattc aaagtaagcg tttcactgat gtgttcggaa 1380
tatattgaac cgaaagttca tgatattgaa tttgaaattg tctaa 1425
<210> 386
<211> 414
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(414)
<223> BLCPAMOF_01899
<400> 386
atgaaaataa aactgatcga ctttggcgtg ccggagcacc agcgtcctta ccgtccgcat 60
ggcaatgatg ccggagcgga tgtttatctg ccctatgact gtaccttaca gcccggagaa 120
atcgccaaaa ttcctttggg ttttggactg gaaataccgg atggatatgc gggatatatc 180
tttccccgta ccagcatggc ggtaaaaggt ctggtctgtg aactgccgcc tgtggattcc 240
ggctattgtg gagagatcca tgcgatcatc agcaatgtaa gcaatcaggc gcagtctctt 300
tttaagggag cccgtatcgg gcagcttgtg atcacgccga tcgtcattgc ggattttgta 360
accgatctgg gaacagaacg aggaaccggc agctttggca gtaccggcga atag 414
<210> 387
<211> 270
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(270)
<223> BLCPAMOF_00373
<400> 387
atgaacgtat tcaccgaaat cagtacccgc gaactggaaa acaccctcaa gggcaaggct 60
gtccactaca tcgtcaacga tgcaggggaa gggctgtgct tattctttga gggctggacg 120
gacaacaccg gctcaaacca cggtgacgct atccacatca gcccggtcat tgatgcagct 180
ggcaagccgc agcttgttgt gcagtatgtc ccggaagagg aacggcccga agacagcgaa 240
acatgcaaca acggcgttgt gggtgagtaa 270
<210> 388
<211> 384
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(384)
<223> BLCPAMOF_01894
<400> 388
atgagtgacc gaaaaacctt tgaatatggc ggttatcact tcacgcccat acgaaaattt 60
cacaaaaaag aaggcgactt tttcgtcata tcgaaacggc tggcaagtga cttcaactta 120
gggttgtgta cctatcagga tcggcaaaaa gcaccttatg attacaaaga cttttatacc 180
gtcgcaaccg acaaagaatg tgacattttc cggtgcgaag aaaatggttt gttgtatgtg 240
ccggggaaaa acgaactttt tatttaccat gaaccaaaac agaaaaagcg gaactctatt 300
gccgatgccc tttcacagtc caggaatgtt actgatataa ccggattttc cagcggccgg 360
caaagaagtg ccccggaaag gtag 384
<210> 389
<211> 387
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(387)
<223> BLCPAMOF_00371
<400> 389
atgaaccaaa gacaacgggc attttgtgaa gcctacctca agtgtgggaa cgcagcggag 60
gcggcgagga aagccgggta cagtgccaga accgcccgga gcatcggcca gcggctgttg 120
acatatgccg acattcggga atatctggcc gaccgtaacg cggagatcat ggccgagaac 180
acagcgaccc ttgaagaaat ccgcagcttt tggacaacca caatgcgaga tcaggaggcc 240
aagcaggccg acaggctcaa ggcctccgag ctgctttcaa aggcgctcac tctggaacgt 300
gctgccgctg gcacgttgaa cccattcgac agcttgacgg atgaggagtt gcgcaggctt 360
tccgcgtttg atgatggttt agagtaa 387
<210> 390
<211> 126
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(126)
<223> BLCPAMOF_01896
<400> 390
atgtggaacc tgatttcaca tttccttacc tttgccggag gaatggcttc cggcgttatg 60
ttgatgtgtc ttatgcaaac cggaaaactt gcggataaag aatttgaaac tatgaaggag 120
gaataa 126
<210> 391
<211> 921
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(921)
<223> BLCPAMOF_01891
<400> 391
atggaaaaga aactgaccta tggtgtatgg gcggtacgaa gcagcacttc tattttcgga 60
ccggcacaaa gctggtgcaa ggaaaatgga aaaccgttgg aatttgatag caaagccgat 120
gctgaaaact atgcaaagga agccaacgag catacgacag caaatgtccg atactatgtg 180
aaagaaaaag aaccggaacc cggtgctgtt cggaaaggaa catctcaacc ggagctggat 240
gcacgcagcc atgaagaagt gacaccaaga aatgatgcat cggaaaaaca aaatgagatt 300
ccgggcagac agattccttc tcaaacagat ccgctggtag aaatccgctc tgcggttcat 360
agtaattacg caggcatggt cgctatgctg ggtgcggaca accgtgtgta tttggggcgt 420
gaggaacgct gccattgtca ggatatgcag ccatcttact atgacaatca ggatggttcc 480
ctgtgctttg tctgtgatca gcccgacatg tattattttc tttatggaga aggctgggcg 540
catacccaga cggaaatgct ggaacgaggg cttaccctgc gccagtatga agaatttgcg 600
agactgcaaa atggcgtcct tgcacagttt accacacaaa gagaaatcct gtttgccgga 660
cagccatttc aagcgccaga aagttatctt cgcaatgcgg aactttatga ggaaggacaa 720
accggcaact acaatatgct ggatggcagg ctgaacaacg aacctcttgt gcgtccggat 780
ctgacagatg gacagacgga tgaagaaatc cgggagctgg tgccggaagc aaagccgtcc 840
ttgatggacc gtctgaaagc agataaaccg gagcatgaag caaggcagat gatccctccg 900
gtgccggaaa gggaacgctg a 921
<210> 392
<211> 372
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(372)
<223> BLCPAMOF_00375
<400> 392
atgccagacc acgccaaaca ggttggcgta ctgtgccagc acgttattga tctgctgggc 60
ttgaccatga aagaagggca gagtattcta ctcggtgaat ccaacattgc ccacatggtc 120
agcaaccacc cggcagatta tgccctgtat ggggagtata tcccgctgat tctgtctgcg 180
ccggactatg tagccctgaa tgcaaaggac agctcgattg aatacgtcaa ggaagttcag 240
gtaaacagca tatacgtcaa ggtggctgtc cgtgtttcgg ctcgtgggca gctctttgcc 300
cggtcgattt atcggctgaa cacaaaccgc gttctaaact ttatcgaaaa aggcacgttg 360
aagcggtatt ga 372
<210> 393
<211> 633
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(633)
<223> BLCPAMOF_01892
<400> 393
ttgaatatca acacgattac tgcggaggat cttcgccgca tgccggataa ggaaggactg 60
attttacagg gctgtggcgg ggatctgaca gaatgggtag acggaatcaa tgaaatgctg 120
acacaggcag gcatattgaa agatggcagt cagtttgaga atgtgtttgc ttttcagcac 180
ggagaactga cctgtttgct ttacccgttt gatgatgtga aactggatat aggaaaactt 240
gccctgtggc gtttacagac ccatgaagtc tatggcggca catggctgtc ggactttgtg 300
ccgaattatt taggcggatt tatagaaaca ccggaagcgt tggcagataa accggattgt 360
ccactgatcg gagcagatgg gaacattttt aatctgctgg gtattgcttc ccgtactttg 420
cgggagcatg gtctgaaaga acaggcaaaa gaaatgtctg atcgggtatt tgcttccggc 480
agttatggag aagcgctctg tatcattggc gaatatgtca acatcacaga ttccgaaccg 540
gagcataaga attctctccg tcagcagcta aaagcaacaa aaccggcaga cccggtaaaa 600
aagcagcaaa cttccaaaca gcaggaacga taa 633
<210> 394
<211> 594
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(594)
<223> BLCPAMOF_00272
<400> 394
atggaatttc cgggtgagaa tatagccgca acggttgccg agaaagtttc ggatatcgtt 60
atcgccaaaa tgaatattaa tgaagagaaa agaaatcgtg agtttaccta tcagctaaag 120
gaactcgaat tttacaaaag cggatatgat aaggaattac gggcactttt tgactattgg 180
acggatttgg tttggcttgc acaatttaaa gataatgaac tattgagcga acaggaaaga 240
aaacgctaca acaaacaatt cgatgacatg attaaaatag ataaaattgc aaagaacaag 300
attaatacaa tcaaatatgg aggaaaggaa accggacgag tcttagcact tcagtcaaag 360
ctgcaacaag caaaatataa agaccaacct atgctggtaa tggtttatat gtggtgctca 420
atcattgcag tactaaaaag agaaattttg ggtcagacca ttagcacaac agatattatg 480
caaatactta taacaaattt ggatgaaagc atggatgaaa taaaaaagtc tcaaaattat 540
atttctaagg tgtatcaaga aacttacgga gaactgccat attggacaga ataa 594
<210> 395
<211> 237
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(237)
<223> BLCPAMOF_00273
<400> 395
atgaattatt tttacaatca aatgtttaat ccacaatatg taaaccctga ttattacgct 60
atgcttcaag cacaagccgc taaacagtac caacaaaacc agagcaatga ggtgcagaaa 120
gctgtgaaag caacatatga cttatgcgag gcagtcaaca aattggatgc agagcatcag 180
caacaagcat tctatgcctg tttgacagtt ttagctgctg aactgggttg gaaatga 237
<210> 396
<211> 105
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(105)
<223> BLCPAMOF_01480
<400> 396
atgatccata ttctcacaat cctggagtct gccgtggcaa atataatttc acattatatc 60
tgcaagtggc ttgacagact cgacaaggac cgtaagcccg actaa 105
<210> 397
<211> 762
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(762)
<223> BLCPAMOF_02480
<400> 397
atggacaaaa aattgtatga taaacgaaaa aaaccggatt gcaaaaaaga acaacagcga 60
aaagaaattt ttagtacata ttcggaattg tgtcctcaaa agcctcaaga taaccgcctt 120
tcgggtttgg aaactggaaa taaaaagaca ggtaaatctg gaagaattta tgacaaaata 180
ttagtatgga atatccctcc gagaatcact tgccccggag tatctgattg gtgctccacg 240
cattgttata atgcagatgc cagaaaagat gtttatacaa ttgaccgatg gtgtgaaaat 300
ctgtgggatt ttcattttcg gttacccgaa ctgaaggaca aaattgaaaa ccaaataaac 360
gaaaccactg gacgatgtgc ggttcgattg cattctagcg gagacttttt ttcagaagag 420
tacattgatt tttggaaaga aataatttta gaatttccaa aagtctcttt ttgggggtat 480
acaaggacat ggaatgtccc ttgcttaaaa gataatgtga acgagcttat gaatcttaat 540
aatatgcagc tgtttgcgtc atatgacaca acgatggcaa catcggttcc tgcgattcct 600
aaaagcttgg tctttgatac aaaagaaaat ttgtttgagt atgcggtgaa gcatacagat 660
agcataattt gcccggagca gtatggaaga gtggaaagct gcgctgactg cggcttgtgc 720
atgaagaaaa caaacaagga tattttattt cagttacatt ag 762
<210> 398
<211> 186
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(186)
<223> BLCPAMOF_00276
<400> 398
atgaaaagaa aagcggtagt cgtttggcgt tcgtgtattt cgtccagacc ggacaagctc 60
aatgaagcca gcatctacaa gctctttgat gtacttgcgg gcggttcgct ctttgatacc 120
aagagctttc atcttaagcg caggaaactg aaaatcgcgg cttccagctg cttcattggc 180
ggctaa 186
<210> 399
<211> 108
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(108)
<223> BLCPAMOF_01168
<400> 399
atgcaattct gccaaaagtg tttcgaggtt attgatttat tccacaaatt atgccatact 60
atagtcactg aaaccgttcc cgacaccgtt cccgaacaat ttcagtaa 108
<210> 400
<211> 858
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(858)
<223> BLCPAMOF_01004
<400> 400
atggcgaata gcaaagtatg gaatgtgtta tatagagcta ctgaggattc agcatggaag 60
aaattaagag gtagaaaggg attttggtac gctgatccga ttttgttcaa aaaagggact 120
gatacatttc tatttactga agcatttaat aaaaaaatac aaaaaggtta cttagcaatt 180
tcgagaatgg agaatgaaga attttctgta cctcaaatta ttatgaaaag accttttcat 240
ctttcatatc catgtgtttt tgaatatgaa aacacagcat atatgattcc cgaaacggga 300
caaaatggta cattggaatt gtggaaagga tctgatgact taactaaatg ggagaaagta 360
tgcgtgttgt taagtcatgt aagatttgct gacacaaccg tttacattga agacggtaaa 420
gtatatcttt tctcttacga agaagcagaa aaatataaga cgcatatttt tttgctagat 480
atgaatagtt atcatataag agaaatcgag gagattactc atagtgagaa tatatatagg 540
cctgctggaa aattttatac tgaaagcgga agattattta ggcctgttca gtataatgta 600
aatagttatg gtgaaaaaat tctgattaat gaagtgaatt ccattcatcc gtttaaagag 660
acattctata aagaaataac cgcagataac tatttacaga atttaagagg ttgtaataca 720
catacctttt cgattgtagg tggtatttgt gcagtggatt acttagttga ggttaacctt 780
ccgatatttg aaagattagt tatcataaga aaaattcgta acaagttcta caaattgaag 840
tttaaattgg gaatataa 858
<210> 401
<211> 267
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(267)
<223> BLCPAMOF_00279
<400> 401
atgaaattca aagtgcgtat cccactccag tatgttaagc ccgtctgtat cgccgccgtt 60
ctcgtgggca tctttgctgt tgcagcgggc agctggatca ccggcctgtg tctgctgctg 120
ggcgcttacc tgctggagaa aagctgctac cgctgccccc actgcggcaa aaagctggat 180
atgaagtacc cgctgttcaa gggcagctgc tgcccggcct gcaaggcaga gctgcgcccg 240
gcagcagaaa aaaacgccgc gaaataa 267
<210> 402
<211> 153
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(153)
<223> BLCPAMOF_02814
<400> 402
ttgaaatact ttgaattcgg acaggagcac ccggaactga tggtgatgct ccacggcggc 60
gtatgctatc gtggcgcgct gacggtagct gagaaaatgg caaagaccta tcatgtggtg 120
ttggtggcct accctgagct tgtttgcctt tga 153
<210> 403
<211> 1248
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1248)
<223> BLCPAMOF_01003
<400> 403
atgacattat ttactttgat atggggtgcc tgtatgctct atggatttac tcgaaagaat 60
atgaacgcaa tggttgcaat gacattgtta tttatgacat ttcaatgtgc gaatgtcata 120
agctttgggg gcttttctgt aggtccacaa attttaacat caatgtgttt gattgttaga 180
tttttaatat ttagtaaatt tagagtatac aaaaccaaat ataataattt agtcaatgta 240
ttgctagttg ttttagttat agaagtcatt atatctgctc tttataataa tgtgattagc 300
aaaaattatt tatatatatt acaattaaca acatatgtgc tctgctttgt ggtattaaga 360
tattcgtcta cgacgtttga tgaagtttca ctatatgaga tgttaagagg agttattatt 420
tttgttgctg tggtaggaat cctacagtgg ttagcgacta tggatatact tcctataaaa 480
cggattttga agatattgtt ttataacgat gatagtatga acatctattt taatgaaaat 540
gattactatc ataatagcag ggtttattcc acatttatgg agccatcata cttagcaggt 600
tttgctgttg gcgcttttta ctatttgcta agcttaaagg aaaaatggaa gagtaatacg 660
ccattattta ttattctttt gatagagatt gttctctcta ctagttctac agcatatgcc 720
gcaattgttt tggtaggagt tatttttatt gttaatgcaa gacagatcag tcttactaaa 780
aagtgtactt tagttttctg tgcgggtatt gcttttgccg ttttgtattt gcagtattat 840
gaattgttag aaaaagttct gtttaataag tggaattcta actctggcgt tgcaaggagg 900
ataatggata atgatgcttt aaacgctttt tactcatcaa aattattagg agtcggttat 960
aaatgcgttc gaggaagcag tgttttatat agtatgcttg gagaaatagg aattatcggg 1020
acggtcctat atacaacgac aaatgcagcc ttgtatattc ctattattaa taataggttg 1080
attagaagca aattgcctaa taattataca gctgttttgt ttggcttgct ttcagcgttt 1140
gtttgtttga tcatagcagt acctgacatt gatatgtgta catattggtt ttggatgtat 1200
tgtttggcaa tttgtatggg gtacaaaaaa acggatcctc agagttga 1248
<210> 404
<211> 291
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(291)
<223> BLCPAMOF_02765
<400> 404
atgaattatc ctgtcgaata tactgtgatc acggaaaatg aaaaaatcta tattgagggc 60
ggcgccgatt attgggggct gttcaactac ctcatcggcg actatctgcg ggactcggtc 120
ctgagtgaga ctcgctcggc tgtctggaac agcgccaaga agggttctac tgagccgctg 180
cagaactggt tcaagaactt caagagcatg gggatcatgg gtatgatcgg ctacatctat 240
ggtatctacc acctgggcga gaagatcgat acttacctga ccaagaagta a 291
<210> 405
<211> 477
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(477)
<223> BLCPAMOF_00724
<400> 405
atgccgaaca ttgttcttac gcggatcgac aaccgtcttg ttcacggtca ggtcgcaacg 60
cagtggtgtg gcgccattgg tgcaaacctt attctggtgg ccaacgacga agtggctggc 120
aacagcctgc gtcagggtct gatgaatatg gccgctcctg cctacgctgc aatgcgttac 180
tggaccgtcc agaagacgat cgacaccatc cacaaggcca gcgccaagca gctgatcttc 240
atcgtctgcg agaacccgca ggatgtcgtg aagctggtgg agggtggcgt tcccatcaag 300
aaagtcaaca ttggcaacat gcacatggca gaaggcaagc gccaggtggc aggttccgtc 360
gcagttgacg acgccgatgt ggctgcgttc aagcggctgc aggagcttgg tgtggaactg 420
gagatccgcc gcgttcctac cgaacacgct gaaaacatcg aaaagctgtt caagtaa 477
<210> 406
<211> 819
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(819)
<223> BLCPAMOF_00725
<400> 406
atgggcttta gtgcacttca gatcattctg gtctttgtgt gggtgttcat cgtcgccatc 60
gaccagtttg atttcctgga atccctgtac cagcctatcg tttccggtgc tgtcatcggt 120
gcgatcctgg gcgaccttcc cactggcctc atcgtcggcg gtacttacca gctgatgacc 180
atcggcaaca tgcctgtcgg cggcgctcag ccgccaaacg cagtcatcgg cggcgtcatg 240
gctaccgtgt ttgcgatctc ttctcatctg gataccaccg ctgctgtcgg tctggcagtt 300
ccctttgctc tgatcggcca gtacatggtt accttcctgt tcaccctcat gtcccccatg 360
atgtccaagg ctgaccagct ggcagcaaag ggcgacacca agggcatcgt tcgtctgaac 420
tatctggcaa tggctctgct gggcctgctg ttcgccatcg tctgcaccct cggtatgctg 480
ggcggctctg caatgggtac taccctgagc aacctggctg ccaagtatgc atggatcatg 540
gctggtctgg gcgctgctgg cggtatgatg cgcttcgtcg gtttcgctac cctgctgcgc 600
atcatgcttt ccaacgagtt ctggggcatc tactttgccg gtttcgctct ggcaaccatc 660
atcggctaca tccccgagct gtccggttct gctctgctgc tgatcgcatt cgttggtatt 720
gcgatcgctc tgtatgacta ccagactcgc gttgctatca agcaggctgc tggttctggt 780
tttgctgcga atggaggcga cgacgaagat ggcatctaa 819
<210> 407
<211> 828
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(828)
<223> BLCPAMOF_00726
<400> 407
atggcatcta atgcaactca ttacaacaat ctgactcccg cgcagccttt ggataaggct 60
acgctgaaca agatggtgct tcgttccctg aacctgcagg catccttcaa ctacgagcgt 120
atgcaggccg ccggctggct gtactgcatc ctgcccggtc tggagaagat ccacgcagac 180
aacaaggaag acctggagct ctccatggag cacaacctgg agttcttcaa cactcacccg 240
ttcctggtca ccttcgtcat gggcatcatc ctctctctgg agcagcagaa ggctgacatc 300
gaaaccattc gtgccgtgcg tgtcgccgct atgggccctc tgggcggcat cggcgatgct 360
atcttctggt tcactctggt ccccatcacc gcaggtatca cctcgaacat ggccatcaac 420
ggttcgctgg ctggccccat cctgttcctg ctgatcttta acatcgtgca gttcgcatgc 480
cgcttcttcc tgatgtactg gtcttacaac ctgggtacca aggcgatcga catcctgact 540
gccaacgcta aggagttcac ccgtgcagct tccatgctgg gcgtcttcat cgtcggtgct 600
ctgacttcca actacggcgg caccaccgtt gctaccgtca tcgagaacgg cgacagcccc 660
atcgttatcc agagcattct ggatggcgtc ctgcccaagc tgatccctct ggctctgacc 720
ctcggcctgt tcttcctgat gaagaagaag aactggaagc ccgttacctg catcgctctg 780
ctgctggtca tcggtctggt cggcgcattc ttcggcatct ttgcttaa 828
<210> 408
<211> 852
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(852)
<223> BLCPAMOF_00721
<400> 408
atgtccttag ttacgaccaa agatttgatg ctcgacgctc agaagaacca ttacgccatc 60
ggcgcgttca atgccgagaa catggagatg gtgcaggcca tcatcgccgc tgctgaggag 120
ctgcgcgctc ccgtcatcgt ccagaccacc ccgggtactc tgaagtacgc ttctccggcc 180
atgttccacg ccatggtggc cgcagccgct tctgaggcaa gcgtccccgt cgtgatgcac 240
ctcgaccacg gcagcagcta tgagctggcc atgcaggcat tccgtgccgg ctacacctcc 300
gtcatgatcg acggctctca ccatgtgttt gaggagaaca tcgagatcac caagtccgtt 360
gtccgcgcct gccacgctgc cggtatcccg gtggaggctg agctgggcaa ggtcggcggc 420
aaggaagacg accttgacgg cggcaatggc aacggctaca ccgtcccctc cgaggctgct 480
gagtttgcag agcgcaccgg cgtcgattct ctggctgtcg ccatcggcac tgcccacggc 540
gtctacaagg gaactcccaa gctggatatg gagcgcctga gcgagatccg caaggtcgtg 600
tctgtgcctc tggtgctgca tggcacctcc ggcgtgccgg atgacgctgt ccgcgagtgt 660
gtcgcacgcg gtatgtgcaa ggtcaactac gccaccgacc tgcgtattgc cttcagcaag 720
ggcctgaagg aatacctcgc caaggacccc gaggtcttcg accccaagaa gtacagcgcc 780
gtcggccgcg agtacgtcaa ggaatacgtc aagagcaaga tcctggtctg cggcagcaac 840
ggcaaggctt ga 852
<210> 409
<211> 1434
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1434)
<223> BLCPAMOF_00554
<400> 409
atgtcacctc tacattttgt gatcatgctg atcattgcga tcatcatcct gaccgtcctg 60
accctgaaat tcaagatgca cccggtcatg gttctgtttc tgacggccac cttctgtggt 120
ctggcctccg gcaagaccct cgtggacacc ttttcttcca tcaccaagta tttcggctcg 180
actttaggct ccattggtgt tatgattatt tttggtgcag tcattgcatc gggcatcaat 240
gacaccggcg ctgccaccag catggtcaac ttcttcatca agaagttcaa gggcaagtgc 300
ctcgagctgg ccccggccct gaccggcttc atcatgagca tccccgtttt cggcgacatc 360
gccatcatcc tcaatgctcc catttctgcc atccttgcca agcgcaagaa gctgggtatg 420
cagcaggtcg ctcccttcgt taacctcggc ctgaccctga cccacggtct ggtgcctccc 480
acccccggca tcctggcagt ggccatcctg ctgggcgctg acatcggcac cgtcatcatc 540
atcggcctca tctgctccgt catctccttt gccgtctgct acctcggcct gcgccccgtc 600
tacgccaagg gcgagtatgt tgctccgctg ccccagtaca ccgagggcat cgaggctgtg 660
gaagacacca acgatgtcaa cgccctgctc atcaaagagg acaacactcc cagctccggt 720
gcttccttcg ctcccctgct gctgcctgcc gtcatgattg ccatcggctc catcggcaag 780
ctgttcactg aagaaggttc cgccgcctac agcttcttca acaccttcgg caacaccgtt 840
ctggctctgt tcatgggcat catcgctgtc ggctgcctga tcttcggccg caaggacaag 900
gtcgtcaaga aagccaatgc tgacggcacc ggctgcaagc tgaccgagaa gagcagctgg 960
ttcgagatcg tcatgaacaa ctgggtaggc cgtgctctcc agatcgccat cggcgctctg 1020
ctcatcaccg ctatgggtgg tgctatgggc ggcatcctcc gcgagaacga agccatcgcc 1080
accatcggcg gcatgatcgc cgagagcagc ttccccgctg tgctcgtccc cttcctgatg 1140
gctgctatcc tgatgaccgt ctgcggctct atgaccaccg ctgcgatgac cgctgcaggc 1200
ctgatgggcg gcctgatgac cgttctgggc ctcgaccccg tcctcaccac tctggccatc 1260
ggtgcaggct ccatggtcgg ctggcatgtc aacaacagcg gcttctggat tttcacctcc 1320
ctgtacggct ttgataccaa gcagggtctg aagtacttta ccaccaccaa cgccctcggc 1380
ggcatcgttg ctttcatcgt gctggtcatc ctccacgctg tgggccttgt ctaa 1434
<210> 410
<211> 774
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(774)
<223> BLCPAMOF_00746
<400> 410
atgaagacgc ttgctgcaag cctttccatc ctgacaagag aaggcgtcat gctctacctg 60
ctgcgcggcg tggccttcac ctgcatcatc tcggtgctgg gcgtcatcat gggcctcatc 120
gtgggctctc tgctggcgct ggcccgcacc tactgcaaaa agggtccgac ccgcatcctc 180
ggctggtttg ctaccgccta catcgagctg ttccgcaaca cgccctacct gctctggatc 240
ttcatctgtg tggtgttctg cccctgcccg ggcttcttcg cccgcaagat gttcggcctg 300
accagcgtgg agatgaagct tctgttcaag gccgctctgg ccctcatcct cttcaactcc 360
tccgtcatcg cggagatcgt ccgcggcggc ctgaacggcg tgtccaaggg ccagttcgag 420
gccggctatg cacagggctt caacaccgct gaggtgctgc tctacatcgt cctgccgcag 480
gcttaccgca acatcgtgcc gaccctgctc agccaggtca tcaccaccat caaggactca 540
tcctatctgg caaacgtggc caccatcgag ctgatggccc gcatccgcca gctgctgagc 600
gccgccggta cttacaacgg tctcggcacg gtgaacgtct ccgacgtcat ggtgctgttc 660
ggcacggcct gcgtcatcta cttcatcatc aacttcaccc tgagctgtgt ggtgcgcaca 720
atgcagaacc gccgcaagaa ggctctggtc tttgccccgg caaaggccgc ataa 774
<210> 411
<211> 741
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(741)
<223> BLCPAMOF_00745
<400> 411
atgtctggct tgttttcgtt agagtcctgg tccaccgtct ggacgcatcg tgagagtttt 60
ctgctgggtc tgggcaacac gctgcagacc gccgtctgcg cactggcgct ggccttcatc 120
atcggcgctg cgctgggcct gatgtccacc agcggcagta agctgctgcg catcatcgcc 180
cgcatttacg tcgagttcgt ccagaacacc ccgctgctgc tgcagctgtg cttcctgtat 240
tatgcgctgg catttgcagg tgtgagcctc ggcgtcatcc gcaccggcat cattgcattg 300
ggcgtttaca ccggcgctta catgggcgag gtcgtccgcg ccgccatcga gtctgtgccg 360
aagggccagt tcgaggccgc acaggcgcag ggtttcaact atctgcagcg gatgggctac 420
atcatcctgc cccagagcat ccccgtgatg ctccctccga tggtcaacca ggtggtcaac 480
ctcttcaaga acacctcctg cctctacatc gtgggcggcg ctgacctcat cagcgtgacc 540
tacagcttcg tcaccggtgc ttccaccggc ggcgcatacg cccccgctta tatcgtctgc 600
ggcctcatct tcttcgtggt ctgcttcccg ctgtccacgc tggcagcccg ctgggaggct 660
tccctcaagg agcgcaaggg ccgtgtgaac ccgggtctca agaccgctgc caagaaagta 720
gagctgaagg aggctgcctg a 741
<210> 412
<211> 726
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(726)
<223> BLCPAMOF_00743
<400> 412
gtgatcaaac tcgaacacgt tgacaagtac ttcggagacc tgcacgtcct caaagacgtg 60
aacctcgagg tcgccgaggg cgaaaagctg gtcattatcg gaccgtccgg cagcggcaaa 120
tctaccaccg tccgctgcat gaactttctg gaagagccga ccagcggcca cgtctacatc 180
gacggtcagg agctgaccaa caagaacaag accaggatcg tccgcgacaa catgagcatg 240
gtcttccagc agttcaacct ctacccccac atgacggtgc tcaaaaacct gacgctggca 300
cccatgaagc tccatcacaa gaccaaggca gaggccgaag agctggcata tcattatctt 360
gaggtcgtcg gcctccggga caaagcggat gtctaccctc cgcagctgtc cggcggccag 420
cagcagcgca tcgccattgc acgcgccctc tgcgcacaga ccaagatcat cctgttcgac 480
gagccgactt cggccctcga ccctgagacc atccaggaag tgctggatgt catggtaaag 540
ctggcacacg agaagaacat cacgatggtg gtcgtcaccc acgagatggg ctttgcacga 600
aacgtggccg accgtatcgt ctttatggca gacggccaga tcattgagga aggcacgccg 660
gagcacttct tcaccaaccc caagaacgag cgcgtccggc agttcctgag caagatcgtc 720
cgctga 726
<210> 413
<211> 588
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(588)
<223> BLCPAMOF_01625
<400> 413
atgaccgaaa aagagaagat gctggcccat cagatgtacg acgcaaacta caacaaggag 60
ctgcacgatg agcgcatcgc agccaaggag ttgtgctggg agtataatca gctccgcccg 120
tcgaacgaag agggccagag agcggtcttg aagaaacttc tcggcaagac gggggagaat 180
ttctacatca ctgcgccgtt ctggtgcgat tatggctaca acatcgaact gggcgaaaat 240
ttctacgcca accacaacct ggtcatcctt gattgtgcta aggtgaaatt cggcgataac 300
gtcttcgttg cgccggactg cggtttccac accgctggtc accctatcga cttcgagcgc 360
cgcaacgccg ggtttgagta tgcctaccct atcacggtgg gggacaatgt ctggatcggc 420
gcaggcgtgc aggtgatgcc gggcgtgacc atcggcagca atgtggtcat cggcggcggc 480
agcgtcgtgg tgaaggacat ccccgataac tcggtggctg tcggcaatcc ctgccatgtc 540
atccgtgcca tcaccgatga ggacaaaaag acctggtgga gcagataa 588
<210> 414
<211> 357
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(357)
<223> BLCPAMOF_01742
<400> 414
atggtaaata aagtgagagt gaccattgca ggcgcaccct acgccattgc aacgaccgat 60
accgagaact acatcaccac actggccaag aagctggacg atgacatcac gaagctgctg 120
gacaacaacg gcaacctctc tgtgaccaag gcggcggtgt tctgcgcgat ggactatctg 180
gacgagtacc gcaagagcgc gggcagcgcc gagaatatgc gcagccagat acaggactac 240
atttccgatg cagccaaggc gaagctggca gcggataagg tcaaggcgga gaacgagacc 300
ctcaagcggg aaaatgccgc actgcgggaa cagctggcca agctgcagca gaagtga 357
<210> 415
<211> 804
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(804)
<223> BLCPAMOF_00307
<400> 415
gtgaggaaca tccggtggca gaagatggcc ctgcgggcgg cgaacggcct gctggacggg 60
gtgacggctc tgctggtgct gctggcggtg gtctggtcgg gctatgcgct gtgggacaac 120
agccgggtgt acgccgctgc cgacaatgtg caggccgggc tgttggcctt caagccccag 180
ccgcaggagg acaacagcct ctccttcggc cagctgcggg acatcaaccc cgatgtctgc 240
gggtggctga cgctggacgg cacggccatc gactacccgg tggtgcaggg cgagagcaat 300
ttcacctatc tgaacaccga cgtctacggc agctttgcgc tggcgggcag catctttctg 360
gatgttgact gcgacgcgga tttcagcggg cggtattccc tgctctacgg ccaccatatg 420
gagaacgggc ggatgtttgg cgacctcgac aaatacaagg acggcgcatt cttccgccag 480
aacaccaccg gcaccctgac gctgcccggc gggagctatc ggctggaagt gctggcctgc 540
cttgtggtgc ctgcgtcaga acaggccatc tttgccccgg gcaagtggcg ctcggacgca 600
ggcgggctgc tcccctttgt ggaggagaat gcccttcaga tggatgcaca ggcgctccgt 660
gcgctggaag aggagtcgga aggagcgcag ttcctggcga tggctacctg ctcgggggag 720
tacaccgacg cgcggacggt ggtgctggcc cggatggaac caatgtcaga cctgcaaaac 780
ggaaaggagg agagcttatc atga 804
<210> 416
<211> 1383
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1383)
<223> BLCPAMOF_02826
<400> 416
atgagttaca cagcagagcc gaaacagcag gatacgaaca tcaaagtccc tctgatcagt 60
aaaatcgctt acggcatggg cgatgtgggc tgcaacttca gctggatgtt cgttggcaac 120
ttcttgatga ttttttacac cgatgtctgc ggcatcagca tggcggcagt gtccctcctg 180
atgctggtct cccgcttctg ggatgccatc aatgaccccg tgatcggttc gctgagcgac 240
cgcacccgtt cccgctgggg acgctaccgt ccatggctgc tgttcggcgc accggcaact 300
gctgtggtgc tcgtgctgac gttctgggcg caccccacat ggtcagacag tgctaagagc 360
ctgtatatgt acattactta ctgtgtactg gttctgggct acacttgcgt gaacatccct 420
tatggtacgc tctgcggcac cctgacccag aacatcgagg agcgtgcgaa aatcaacacc 480
tctcgctccg tctgtgccat gatcgccatc aatatcatca acatcatcac cctgcctttg 540
atctctgctt ttggcggtga taatgcagca cggggatatc ttctggtgac cgtcctttac 600
ggcggtatct tcaccctctg tcactggttc tgttttgcca aaaccaaaga ggtcgtccag 660
cccccggagc ggaaaaaagt ctcactgaaa aagcagttgg atgcagcgct tcagaacaag 720
ccctacctga ttgcactggc gggtcagttc ctgttcggtg tgacgctgta tggccgcaat 780
gccgacctgc tctattactt caaatatgtg gaaggcaacg agaatctgtt taccatctac 840
tcgatgatcc tgatcgttcc ctccattctg ggtgctgcgg cattcccctt cgtgtttgaa 900
aagctgggca acaaagggca cactgcttcc cttttcgctg ccggaaccgg cgtttccctg 960
attgcgctct atttcttcag tgcagtttct tctcccattc cgttctatac attcgctgca 1020
ctgtcccagt tcttcttctg cggattcaat accgccatct acgccatcgt tcccgactgc 1080
gtggagtatg gcgagtggaa aaccggtgtc cgcaacgatg gtttccagta cgcattcgtt 1140
tcactgggga acaagctggg catggcgatt ggcacctctg cgctggctgg tgtgctgagt 1200
gcattgagtt ttgcccccaa tcaggtgcag aatgctgccg tgcagaatgc gatgcactat 1260
gcattctcgc tgcttcccgg tgcgctgtgg ctggtaacag cgattgtcct gttcttctac 1320
cgaatcagta agcgttcgta taaccagatt atgtccgaac tgaacgctaa aaaagcaggt 1380
tga 1383
<210> 417
<211> 1002
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1002)
<223> BLCPAMOF_02777
<400> 417
atgtatgctg catctcctgc acgctactcc accctgccct accaccgctg cggcaaaagc 60
ggcctgatgc tgcccgccgt ctcgctgggc ctgtggcaca acttcggcga taccgcgaac 120
ttcgagaaca tgcgcctgct ctgccgcacg gcgttcgaca acggcatcac ccacttcgac 180
cttgccaaca actacggccc cgagccgggc agcgccgaga agaacttcgg ccgcatcctc 240
aaggaagatc ttgcccccta ccgcgatgag ctcctcatca gcaccaaggc gggctacacc 300
atgtgggaag ggccttacgg tgactgggga agccggaaat acctgctggc cagcctcgac 360
cagagcctga agcggatggg cctcgagtat gtggacatct tctaccacca ccggatggac 420
cccaacaccc cgctggaaga gaccatgggt gctctggcgc aggcggtgcg cagcggcaag 480
gcgctttatg ccggcctgtc caactacaac ggtgagacgc tggaaaaagc ctgcgccatc 540
ctcgacgagc tccacgtccc cttcgtcatc aaccagaacc gctactccat ctttgaccgc 600
accatcgagc agaacggcct gaaagagact gctgtccggc tgaacaaggg cattatcgcc 660
ttcagcccgc tggcgcaggg cctgctgacc aaccgctacc tcaacggcat cccggaggac 720
agccgcatcc gcaccgatgg ccgctttttg aaagagagcg tcatcaccga agaaaagctg 780
gcacagatac gcaccctgaa cgaaatcgcc gctgcccgcg gccagacgct ggccgagatg 840
gcgctggcgt ggatactgcg ggacggcaag gtcacgagcg tcctcatcgg cgcgtccaag 900
ccccagcaga tcctcgacaa catcgctgcc ctgaacaaca ccaccttcac cgctgacgag 960
ctagaagcca tcgataaggc ttccggattt tacaaggagt aa 1002
<210> 418
<211> 1344
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1344)
<223> BLCPAMOF_02538
<400> 418
atggatgttt ttgagagcaa accgctaaag ctggtcagcg cggcgtttta tatcgtgctg 60
atgttcctca gcttttactg tgcctgctac cgtctgccgg tgggtctgaa atatgccatc 120
aatctgttga tcttcgggtg ggcctgtgca atgttttttc tccgcccgat gttcaaccgg 180
gctatcttct gcctgcgctt ctttgcgctt ttcttttttc cctatctgat gttctggatg 240
tggtcggtgg ccatctggat ctcggagttc cagaccttca actacatcct gcgcggttcg 300
ctgaacattt tctatatgct cacgaacctg atgttcgcgt cggcggcggt ctacctgttc 360
ggtgaggcca ctatgcccct gacgctggtg ggcatgacga tggcgaatgg cttagtggca 420
ttgcaggtgg ctgcaagtgc aggcatcggg acttttattt cggagtacat tcgtctgctc 480
attacttttg cggacgacac cggcggtgcg atgcgccaga tggagctgca cgatatggtc 540
tacggctggg gcgtcatggt catctactac gccatccaca aggagaaaaa ccacaagacc 600
caggccgtct gcttccttat ctcggcgctg ttcttcacgc tgggtttcaa gcgcatcgct 660
gtcccagcgg tgttctgtgc ggcggtgatg taccatatcc tctgcaagtg gagaccgaga 720
catctgcagc tgcttacgga tgtcattgcg ctcgtggcag gcggctgcat ctttttctat 780
ctctggatga taaaatccgg tctgttcgtg gagctggcca atgaattcgg cgtcgatttg 840
atgtatcgcg acatccttta cggatatttc agccagttct tcgagctgct gccgacctat 900
atgggccgag gcatccgatt catctatacc tacgccaccg aagaccccag ctatccgctg 960
gccacggcgg ctacccacaa tgtctatctg gagctgtatc tggaagtggg cttctggtgc 1020
tggtggatat ggatactctt tgagctggca ttccgcatcc accgggtgga ggagcggtac 1080
accgagatac cggcctatgc gctgatggcg atgaaccttt atgtcttctt cacctacctg 1140
accgataata cttccttcta ttatcccatc aacgtcctgt accggatggc tattatggtg 1200
tggtgcctgg aaatttcgga aaacagtgag ctcgtcgatc ccgagagaga accactggcc 1260
gtggtgaagg aaagccgcca gaagaagcgg aacaaaaagg gaaaagaaga aaatgtggag 1320
gaagatttcc acatctgtgt ataa 1344
<210> 419
<211> 1089
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1089)
<223> BLCPAMOF_02575
<400> 419
atgagcagaa tatcagtcaa agacgcagta aagcgctacg ggaataatac ggtcatcccg 60
gacctgaatc tggagatcgg agatggtgag ctgttcaccc tgctgggtcc ctccggctgc 120
ggcaagacca cccttctccg tatgatcgca ggcttcaact ccattgaggg cggcgacatc 180
ttcttcaacg agaagcgcat caacgatatg gaccccagca agcgcaacat cggcatggtg 240
ttccagaact atgccatctt cccgaacctc tccgtccggg acaatgtggc attcggtctg 300
aagaaccgca aggtggacaa ggccgagatc aagaagcgga cagatgagtt tctgaacctg 360
atgcagatca tgcagtatgc cgaccggatg cccaaccagc tttccggcgg tcagcagcag 420
cgtatcgcac tggcccgcgc actggtcatc tcgccggacg tgctgctgat ggacgagccg 480
ctttccaatc tggacgcaaa gctccgtgtc gagatgcgca gcgtcatccg ccacacccag 540
aaaagcgtag gcatcaccac cgtgtacgta acccacgatc aggaagaggc aatggccatc 600
agtgaccgta tcgccgttat gaaggacggc gtcatccagc acgttggcac tccccgcgac 660
atctaccagc gcccgaagaa tgtcttcgtt gccaccttta tcggtcgcac caacatcgtg 720
aatgcccacg tcaaggacgg catcatcacc tttgccgacg gctaccatga gcacattgac 780
gctctggaca aggctgccga gcaggatgtg cgctgttcca tccgcccgga ggagttcatt 840
atctgcaagg acggcaccga tggcatccac ggcaccgtgc aggagtgtac ctacctcggt 900
cttaacaccc actacaccat tgacaccgat cagggcgact cggtggagat cgtggaggag 960
tcctccattg gcgagggtct caagaagggc gagaaggtgc tgctgaaggt caagaaagag 1020
aagatcaacg tctttaccaa ggacggtggt accaatctca tcaggagcga cgcttatgaa 1080
aaacaataa 1089
<210> 420
<211> 309
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(309)
<223> BLCPAMOF_00796
<400> 420
atggcaaatc cgagccggaa aaagcggaag agaaaggcgt ccgtcgtggg cgctgtgctg 60
aaactgctct tccttctgct tttgctgagt atgctggcgg cgtacatcgc aaatcaggtg 120
gcgctcagct ccaagaaagc ggagctggac accctgcagg agcagatcga ccagcagaag 180
acccagaacg aggagatgca gcgcatcctc agtggcgact cggacgacgt gaccgagtgg 240
gtcgcgcggg actcttacaa ttatgcggcg gccaacgagc gcatctttgt ggatgtgacg 300
ggcaactga 309
<210> 421
<211> 1062
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1062)
<223> BLCPAMOF_02824
<400> 421
atgaaaggca caatgaaagt tgcagtcatg aacggcatcg gcaagatggg ctacaccacc 60
cgcccgatcc ccacacccaa agaggacgaa gttctggtca agctggaata cgttggcatc 120
tgcggcagcg atatgcacta ctatgaaacg ggtgcgatcg gcaattatgt agtcaagccg 180
ccgttcgtgc tgggccacga gccgggcggc acagtcgtgg aagttggcag tgctgtcaag 240
catctgaaag tcggcgaccg cgttgcgctg gagccgggca agacctgcgg tcactgcaag 300
ttctgccgtg agggcaaata caacctctgc ccggatgtcg tgttcttcgc tactccgccg 360
gtagacggtg tttttcagga gtatgtggcc catgaagcaa acctctgctt caagctgccg 420
gacaacgtaa gcaccatgga aggtgcgctg atcgagcctc tggctgttgg tttccacgca 480
gccaatcagg gcggtgctca tgccggtcag actgcggtgg tcatgggtgc aggctgcatt 540
ggtctggtct ccatgatggc gctgaaagcc gagggtgttt cccgtgttta cgttgtggat 600
atcatgcaga agcgtctgga taaggctctt gaactgggtg cagacggtgt gatcaacagc 660
cgcgaaaagg atgccgtcca aacgattctc gacctgaccg atggtctggg ctgcgacctc 720
gttatcgaga ctgctggtac agaaatcact acccgccagg ccattgagat ggcgcagaag 780
ggtgcaaaca tcgttctggt cggttactcc aaatccggcg agatgaccct gcctatgagc 840
cttgcactgg acaaggaact gaccttcaag accgtgttcc gttatcgcca catttacccc 900
atggcgatcg acgccgttgc ttccggcaaa atcaacctga agggcattgt gaccaacatc 960
tttgactttg acgacatcca gaatgccatg gacaagagca tttcggacaa ggccaacatc 1020
gtcaaagcag tggtgaagat tgcggaggaa acgaaggtat ga 1062
<210> 422
<211> 1149
<212> DNA
<213> 普氏栖粪杆菌(Faecalibacterium prausnitzii)
<220>
<221> gene
<222> (1)..(1149)
<223> BLCPAMOF_00623
<400> 422
atgaagatcg ttgaagtcaa cacctatact gtccgtcccc gctggggctt tgttgagatc 60
gtgaccgacg agggcctgac cggctggggc gagcccgtgc tggaaggcca ctgcgccacc 120
gttctggcct gcgtgcagga gatgaagccc tacctcatcg gcaaggaccc catgcgcatt 180
gaggactttt ccgctgtgct gtaccgcgcc ggtttctacc gcggcggcgg cgtgctgatg 240
agcgccattg ccggcattga tcaggccctg tgggatatca agggcaagtt cttcaacgcc 300
ccggtctacc agctcatggg cggtgcctgc cgcgacaaca tgcgcgtgta cagctggatc 360
ggcggcgacc gccccagcga cgtgggcgct gctgctctgg agcgcaagaa tgccggcttt 420
accgccatca agatgaacgc caccgaggag ctgcagatga tcgacaccta cgacaaggtg 480
gacgccgttc tggagcgcgt ggccgccatc cgggagagct gcggcaagta tttcggcatc 540
gccatcgact tccacggccg tgtgcacaag cccatggcaa aggtcctggc caagaagctg 600
gaagagttcg accccatgtt catcgaggag ccggtgctgt gcgagaacat ggaggtgttc 660
aaggagatcg ccgctgcctg caatgtgccc attgccaccg gcgagcgtct gttcaccaag 720
tatgacttca agcgcctgct gcaggccggc ggcgtggaca tcatccagcc cgacctgagc 780
cacgccggcg gcctgaccga ggtcaagaag atcgcctcca tggccgaagc ctacgacgtt 840
gccctggctc cccactgccc gctgggcccc atcgctctgg ccagctgcct gaacgtggac 900
gccacctgct acaacgccgt gatccaggag cagagcatcg gcatccacta caacgtgggc 960
aagagcgtgc tggactatgt caagaaccag gacgacttca agttcgtaga cggccgcgtg 1020
cagctgcccg tccgtcccgg tctgggcgtg gacgtcaaca aggaactggt gctggaggag 1080
aacaagaccc cgcacgagtg gaagaacccc gtctggcgtc acaaggacgg cagcgttgcc 1140
gagtggtaa 1149
<210> 423
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 423
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggactggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 424
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 424
ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtgaagga agaaggtatt cgtattgtaa acttctgtcg cagatgacga aaagatgacg 120
gtaatctgta agaaagcacc ggctaactac gtgccagcag ccgcggtaaa acgtagggtg 180
ctagcgttgt ccggaattac tgggtgtaaa gggagcgcag gtggcagtgc aagttggatg 240
taaaatctac gggctcaacc cgtataagca ttcaaaactg tgcagcttga gtgaagtaga 300
ggtaggtgga atttccggtg tagcggtgga atgcgtagat atcggaagga acatcagtgg 360
cgaaggcgac ctactgggct ttaactgacg ctgaggctcg aaagcatggg tagcaaacag 420
gattagatac cccggtagtc c 441
<210> 425
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 425
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120
agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaatacaa gttgaatgtg 240
aaaactatgg gctcaaccca tagttgcgtt caaaactgtg tttcttgagt gaagtagagg 300
taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360
aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 426
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 426
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgagaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 427
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 427
ctacgggggg cagcagtgag ggatattggg caatggggga aaccctgacc cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120
tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240
gaaaactgtg ggcttaaccg acagactgca ttcaaaactg tttttcttga gtgaagtaga 300
ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 428
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 428
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acccaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 429
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 429
ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 430
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 430
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 431
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 431
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agaaagtgac 120
ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240
gtgaaatgca tgggctcaac tcatgagctg ctttcaaaac tgtttttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420
aggattagat accccggtag tcc 443
<210> 432
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 432
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaaccatag gctcaaccta tggattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 433
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 433
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaaccacgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 434
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 434
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaaccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 435
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 435
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga aaagatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 436
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 436
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agcaatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 437
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 437
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aataaatgac 120
ggtacctgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
gcaagcgttg tccggaatta ctgggtgtaa agggagcgta ggcggggatg caagttgaat 240
gtttaaacta tcggctcaac tgatagtcgc gttcaaaact gcaactcttg agtgaagtag 300
aggtaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctactgggc ttttactgac gctgaggctc gaaagcatgg ggagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 438
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 438
ctacgggggg cagcagtggg ggatattgca caatggaggg aactctgatg cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcggggacga taatgacggt 120
acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggggtgtcaa gttgaatgtg 240
aaatcggccg gcttaactgg tcgctgcgtt caaaactgac gctcttgagt ggagcagagg 300
caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360
aaggcggcct gctgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 439
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 439
ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtct tcggggacga taatgacggt 120
acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggtcggcaa gttggaggtg 240
aaagctgtgg gctcaaccca caaactgcct tcaaaactgc cggtcttgag tggtgtagag 300
gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 440
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 440
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attgatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 441
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 441
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaagaagacg 120
gtacccgagg aggaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg 180
caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240
tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300
ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 442
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 442
ctacgggggg cagcagtggg ggatattgca caatgggcgg aagcctgatg cagcgacgcc 60
gcgtgaggga agacggtcct ctggattgta aacctctgtc ggaagggacg aagaacgtga 120
cggtaccttc cgaggaagct ccggctaact acgtgccagc agccgcggta atacgtaggg 180
agcgagcgtt gtccggaatt actgggtgta aagggagcgt aggcgggatt gcaagtcaag 240
tgttaaatct atcggctcaa ctgatagtcg cgcttgaaac tgcagttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg cttttactga cgctgaggct cgaaagcatg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 443
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 443
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgttg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 444
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 444
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaacgagacg 120
gtacccgagg aggaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg 180
caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240
tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300
ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 445
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 445
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agtatgacgg 120
taccgaagaa ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaagca agttggaagt 240
gaaatgcatg ggcttaaccc atgagctgct ttcaaaactg tttttcttga gtgaagtaga 300
ggcaggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ctgctgggct ttaactgacg ctgaggctcg aaagcgtggg tagcaaacag 420
gattagatac cccggtagtc c 441
<210> 446
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 446
ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtct tcggggacga taatgacggt 120
acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggtcggcaa gttggaggtg 240
aaagctgtgg gctcaactca caaattgcct tcaaaactgc cggtcttgag tggtgtagag 300
gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 447
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 447
ctacgggggg cagcagtgag ggatattggg caatggggga aaccctgacc cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120
tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240
gaaaactgtg ggctcaaccg acagactgca ttcaaaactg tttttcttga gtgaagtaga 300
ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 448
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 448
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggtaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 449
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 449
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agtatgacgg 120
taccgaagaa ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggggc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaagca agttggaagt 240
gaaatgcatg ggcttaaccc atgagctgct ttcaaaactg tttttcttga gtgaagtaga 300
ggcaggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ctgctgggct ttaactgacg ctgaggctcg aaagcgtggg tagcaaacag 420
gattagatac cccggtagtc c 441
<210> 450
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 450
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggtaa gttggaagtg 240
aaaaccatgg gctcaaccca tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 451
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 451
ctacgggggg cagcagtggg gaatattagg caatggggga aaccctgacc tagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aaaagatgac 120
ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240
gtgaaaggta tcggctcaac tgatatatgc gttcaaaact gcggatcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 452
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 452
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atatatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 453
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 453
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgatgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg taagggaaga gaaaggactg 120
taccttacaa gaaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaatgact gggtgtaaag ggagcgtagg cgggatggca agtcagatgt 240
gaaacctgag ggctcaacct tcagactgca tttgaaactg ctgttcttga gtgaagtaga 300
ggtaagcgga attcctggtg tagcggtgaa atgcgtagag atcaggagga acatcggtgg 360
cgaaggcggc ttactgggct tttactgacg ctgaggctcg aaagcgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 454
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 454
ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtcc ttagtgacga aaatgacggt 120
agctaaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagataa gttggacgtt 240
taatctatcg gctcaaccga tagtcgcgtt caaaactgtt tttcttgagt gaagtagagg 300
taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360
aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 455
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 455
ctacgggggg cagcagtggg gaatattgca caatggagga aactctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgttg tcagggacga tgatgacggt 120
acctgacgag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggagagcaa gttgggagtg 240
aaatctgtgg gctcaaccca caaattgctt tcaaaactgt ttttcttgag tggtgtagag 300
gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 456
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 456
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggggacga acacaatgac 120
ggtactcgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa aacgtaggtg 180
gcaagcgttg tccggaatta ctgggtgtaa agggagcgca ggcggaactg caagttgggt 240
gtcaaatcta cgggcttaac ccgtatccgc actcaaaact gtagttcttg agtagtgcag 300
aggtaggcgg aattcccggt gtagcggtgg aatgcgtaga tatcgggagg aacaccagtg 360
gcgaaggcgg cctactgggc accaactgac gctgaggctc gaaagtatgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 457
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 457
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaaccatgg gctcaaccca tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 458
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 458
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agaaagtgac 120
ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240
gtgaaatgca tgggctcaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420
aggattagat accccggtag tcc 443
<210> 459
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 459
ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtcc ttggtgacga taatgacggt 120
agccaaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaaagcaa gttgaatgtt 240
taaactatcg gctcaaccga taatcgcgtt caaaactgtt tttcttgagt gaagtagagg 300
taggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360
aaggcggcct actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 460
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 460
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaatccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 461
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 461
ctacgggggg cagcagtggg ggatattgca caatggaggg aactctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120
agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaaggcaa gttgattgtc 240
taaactatcg gctcaaccga tagtcgcgat caaaactact tttcttgagt gaagtagagg 300
taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360
aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 462
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 462
ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtgaagga agaaggtatt cgtattgtaa acttctgtcg cagatgacga agatagtgac 120
ggtaatctgc aagaaagcac cggctaacta cgtgccagca gccgcggtaa aacgtagggt 180
gctagcgttg tccggaatta ctgggtgtaa agggagcgca ggtggcagtg caagttggat 240
gtaaaatcta cgggctcaac ccgtataagc attcaaaact gtgcagcttg agtgaagtag 300
aggtaggtgg aatttccggt gtagcggtgg aatgcgtaga tatcggaagg aacatcagtg 360
gcgaaggcga cctactgggc tttaactgac gctgaggctc gaaagcatgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 463
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 463
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggatcggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 464
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 464
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaacgagacg 120
gtacccgagg aggaagccac ggctaactat gtgccagcag ccgcggtaat acgtaggtgg 180
caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240
tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300
ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 465
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 465
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggggacga acacaatgac 120
ggtactcgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa aacgtaggtg 180
gcaagcgttg tccggaatta ctgggtgtaa agggagcgca ggcggagctg taagttgggc 240
gtcaaatcta cgggcttaac ccgtatccgc gctcaaaact gtggctcttg agtagtgcag 300
aggtaggtgg aattcccggt gtagcggtgg aatgcgtaga tatcgggagg aacaccagtg 360
gcgaaggcgg cctactgggc accaactgac gctgaggctc gaaagtatgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 466
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 466
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attaaatgac 120
ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240
gtgaaatgca tgggcttaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420
aggattagat accccggtag tcc 443
<210> 467
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 467
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaactca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 468
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 468
ctacgggggg cagcagtggg gaatattgca caatggaggg aactctgatg cagcgatgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctttta tcagggacga taatgacggt 120
acctgaagaa aaagctccgg ctaactacgt gccagcagcc gcggtaatac gtagggagcg 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggatagcaa gtcagatgtg 240
aaaactatgg gctcaacctg tagattgcat ttgaaactgt tgttcttgag tgaagtagag 300
gtaagcggaa ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa catcggtggc 360
gaaggcggct tactgggctt ttactgacgc tgaggctcga aagcgtgggg agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 469
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 469
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aaacatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 470
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 470
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggggtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 471
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 471
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agatttgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggctcaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 472
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 472
ctacgggggg cagcagtggg gaatattagg caatggggga aaccctgacc tagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga agaagatgac 120
ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240
gtgaaaacta acggctcaac cgatagttgc gttcaaaact gcggatcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 473
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 473
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atagatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 474
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 474
ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtaca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 475
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 475
ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtct ttagtgacga taatgacggt 120
agctaaagag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggcg 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagacaa gttgaatgtt 240
taaactatcg gcttaaccgg tagtcgcgtt caaaactgtt tttcttgagt gaagtagagg 300
caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360
aaggcggcct gctgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 476
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 476
ctacgggggg cagcagtggg ggatattgca caatgggcgc aagcctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtct tcagggacga taatgacggt 120
acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggattgcaa gttaaatgtg 240
aaatctatcg gctcaaccgg tagctgcgtt taaaactgta gttcttgagt gaagtagagg 300
caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360
aaggcggcct gctgggcttt tactgacgct gaggctcgaa agtgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 477
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 477
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca tagattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaagaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 478
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 478
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcagggacga taatgacggt 120
acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagtcaa gttgaatgtg 240
aaatcgatcg gctcaaccgg tcgctgcgtt caaaactgat tttcttgagt gaagtagagg 300
caagcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360
aaggcggctt gctgggcttt aactgacgct gaggctcgaa agtgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 479
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 479
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggggga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaaccacgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 480
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 480
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atcagatgac 120
ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240
gtgaaataca tgggctcaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420
aggattagat accccggtag tcc 443
<210> 481
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 481
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gcttaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 482
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 482
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcggtgacga aacaagacgg 120
tagccgagga ggaagccacg gctaactacg tgccagcagc cgcggtaata cgtaggtggc 180
aagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggagtgca agttgaatgt 240
gaaaacgatg ggctcaaccc atcgttgcgt tcaaaactgc atttcttgag tgaagtagag 300
gtaagcggaa ttcctagtgt agcggtgaaa tgcgtaaata ttaggaggaa caccagtggc 360
gaaggcggct tactgggctt taactgacgc tgaggctcga aagcgtgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 483
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 483
ctacgggggg cagcagtggg gaatattgca caatggagga aactctgatg cagcgacgcc 60
gcgtgaggga agaaggtctt cggattgtaa acctctgttg tcagggacga taatgacggt 120
acctgacgag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggagagcaa gttggaagtg 240
aaatctgtgg gctcaactca caaattgctt tcaaaactgt ttttcttgag tggtgtagag 300
gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 484
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 484
ctacgggggg cagcagtggg gaatattagg caatgggcga aagcctgacc tagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga agaagatgac 120
ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240
gtgaaaacta acggctcaac cgatagttgc gttcaaaact gcggatcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 485
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 485
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttggggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 486
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 486
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aaggaatgac 120
ggtacctgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
gcaagcgttg tccggaatta ctgggtgtaa agggagcgta ggcggggatg caagttgaat 240
gtttaaacta tcggctcaac tgatagtcgc gttcaaaact gcaactcttg agtgaagtag 300
aggtaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctactgggc ttttactgac gctgaggctc gaaagcatgg ggagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 487
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 487
ctacgggggg cagcagtgag ggatattggg caatgggggc aaccctgacc cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120
tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240
gaaaactgtg ggctcaacct acagactgca ttcaaaactg tttttcttga gtgaagtaga 300
ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 488
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 488
ctacgggggg cagcagttgg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtcc tcagggaaga taatgacggt 120
acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggtattgcaa gttgaatgtg 240
aaatctatcg gctcaactga taggctgcgt tcaaaactgt agtacttgag tgaagtagag 300
gcaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcggcc tgctgggctt taactgacgc tgaggctcga aagcatgggg agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 489
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 489
ctacgggggg cagcagtgag ggatattggg caatgggggc aaccctgacc cagcgacgcc 60
gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga agaaggacgg 120
tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240
gaaaactgtg ggctcaacct acagactgca ttcaaaactg tttttcttga gtgaagtaga 300
ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360
cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 490
<211> 443
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 490
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attagatgac 120
ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180
gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240
gtgaaatgca tgggcttaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300
gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420
aggattagat accccggtag tcc 443
<210> 491
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 491
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtgggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 492
<211> 441
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 492
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgatgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg taagggaaga ggaaggactg 120
taccttacaa gaaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180
gagcgttgtc cggaatgact gggtgtaaag ggagcgtagg cgggatggca agtcagatgt 240
gaaacctgag ggctcaacct tcagactgca tttgaaactg ctgttcttga gtgaagtaga 300
ggtaagcgga attcctggtg tagcggtgaa atgcgtagag atcaggagga acatcggtgg 360
cgaaggcggc ttactgggct tttactgacg ctgaggctcg aaagcgtggg gagcaaacag 420
gattagatac cccggtagtc c 441
<210> 493
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 493
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtggggga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaatccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 494
<211> 440
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 494
ctacgggggg cagcagtggg ggatattgca caatggggga aaccttgatg cagcgacgcc 60
gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120
acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240
aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300
gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360
gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420
attagatacc ccggtagtcc 440
<210> 495
<211> 439
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 495
ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60
gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120
agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180
agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggggatacaa gttgaatgtt 240
aaaactatgg gctcaaccca tagttgcgtt caaaactgta tttcttgagt gaagtagagg 300
taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360
aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420
ttagataccc cggtagtcc 439
<210> 496
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 496
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agatttgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240
tgaaatacat gggctcaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 497
<211> 442
<212> DNA
<213> 瘤胃球菌科(Ruminococcaceae)
<400> 497
ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60
gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atatatgacg 120
gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180
cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagt aagttggaag 240
tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300
aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360
gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420
ggattagata ccccggtagt cc 442
<210> 498
<211> 443
<212> DNA
<213> CAG-41
<400> 498
ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggatcgtaa actgttgtcg caagggaaga agacagtgac 120
ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240
gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300
gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 499
<211> 443
<212> DNA
<213> CAG-41
<400> 499
ctacgggggg cagcagtggg gaatattgcg caatggggga aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga agaaagtgac 120
ggtacctcgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgg caagtcagga 240
gtgaaatacc ggggctcaac cccggggctg cttttgaaac tgccagcctt gagtatcgga 300
gaggaaagcg gaattcccag tgtagcggtg aaatgcgtag atattgggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 500
<211> 443
<212> DNA
<213> CAG-41
<400> 500
ctacgggggg cagcagtggg gaatattgcg caatgggggg aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga ataagatgac 120
ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240
gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300
gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 501
<211> 443
<212> DNA
<213> CAG-41
<400> 501
ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga agacagtgac 120
ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240
gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300
gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 502
<211> 443
<212> DNA
<213> CAG-41
<400> 502
ctacgggggg cagcagtggg gaatattgcg caatggggga aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga agaaagtgac 120
ggtacctcgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggaccgg caagtcagga 240
gtgaaatacc ggggctcaac cccggggctg cttttgaaac tgtcggcctt gagtatcgga 300
gaggaaagcg gaattcccag tgtagcggtg aaatgcgtag atattgggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420
aggattagat accccggtag tcc 443
<210> 503
<211> 444
<212> DNA
<213> CAG-41
<400> 503
ctacgggggg cagcagtggg gaatattgcg caatgggggg aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga aggaagatga 120
cggtacctcg tgagaaagtc acggctaact acgtgccagc agccgcggta atacgtaggt 180
gacaagcgtt gtccggattt actgggtgta aagggcgcgc aggcgggcag gcaagtcagt 240
cgtgaaatgc cggggctcaa ccccggagct gcgattgaaa ctgcaggtct tgagtatcgg 300
agaggaaagc ggaattccca gtgtagcggt gaaatgcgta gatattggga ggaacaccag 360
tggcgaaggc ggctttctgg acgacaactg acgctgaggc gcgaaagtgt ggggagcaaa 420
caggattaga taccccggta gtcc 444
<210> 504
<211> 443
<212> DNA
<213> CAG-41
<400> 504
ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60
gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga agacagtgac 120
ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180
acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240
gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300
gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360
ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtatg gggagcaaac 420
aggattagat accccggtag tcc 443

Claims (15)

1.一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有下述(1)~(28)中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
(1)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(2)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:21或54记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(3)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:18或55记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(4)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:9或30记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(5)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:19或33记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(6)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:17或34记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(7)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:3或43记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(8)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:6或53记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(9)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:7或35记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(10)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:2或39记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(11)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:25或41记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(12)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:23或50记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(13)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:24或45记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(14)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:26或48记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(15)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:8或40记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(16)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:4或37记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(17)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:13或38记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(18)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:16或56记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(19)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:14或57记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(20)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:27或36记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(21)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:12或42记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(22)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:15、31或49记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(23)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:5、52或51记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(24)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:20或44记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(25)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:1或32记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(26)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:11或29记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(27)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:10或47记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(28)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:28或422记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
2.根据权利要求1所述的组合物,其中,所述普氏栖粪杆菌为具有所述(1)~(28)记载的28种DNA的普氏栖粪杆菌。
3.一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有下述(1)~(3)中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
(1)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:22或46记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(2)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:21或54记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列;
(3)包含编码下述氨基酸序列的核苷酸序列的DNA,所述氨基酸序列为相对于序列号:18或55记载的核苷酸序列所编码的氨基酸序列具有40%以上的同源性的氨基酸序列。
4.根据权利要求3所述的组合物,其中,所述普氏栖粪杆菌为具有所述(1)~(3)所述的3种DNA的普氏栖粪杆菌。
5.一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有选自下述DNA组中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
分别包含序列号:58~207相关的核苷酸序列的150种DNA组,其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列,N为58~207中的任意者。
6.一种用于预防或治疗脑功能下降或者维持或改善脑功能的组合物,其含有具有选自下述DNA组中的至少1种DNA的普氏栖粪杆菌、该微生物的成分、或该微生物的培养物作为有效成分,
分别包含序列号:208~421相关的核苷酸序列的214种DNA组,其中,序列号:N相关的核苷酸序列为编码相对于序列号:N记载的核苷酸序列所编码的氨基酸序列具有40%以上同源性的氨基酸序列的核苷酸序列,N为208~421中的任意者。
7.根据权利要求1~6中任一项所述的组合物,其中,所述脑功能为认知功能。
8.根据权利要求1~6中任一项所述的组合物,其为食品组合物。
9.根据权利要求1~6中任一项所述的组合物,其为药物组合物。
10.一种由保藏编号NITE BP-03169规定的微生物。
11.一种由保藏编号NITE BP-03196规定的微生物。
12.一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的所述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的所述定量值低于所述对应值时,判定所述被检者为轻度认知障碍的状态的工序,
并且所述微生物为选自由属于粪杆菌属的微生物、属于厌氧棒杆菌属的微生物、属于CAG-41属的微生物、属于巴恩斯氏菌属的微生物、及属于瘤胃球菌属的微生物组成的组中的至少1种微生物。
13.一种轻度认知障碍的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的所述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的所述定量值高于所述对应值时,判定所述被检者为轻度认知障碍的状态的工序,
并且所述微生物为选自由属于普雷沃菌属的微生物组成的组中的至少1种微生物。
14.一种阿尔茨海默病的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的所述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的所述定量值低于所述对应值时,判定所述被检者罹患了阿尔茨海默病的工序,
并且所述微生物为选自由属于布劳特氏菌属的微生物、属于纺锤链杆菌属的微生物、属于瘤胃球菌属的微生物、及属于真杆菌属的微生物组成的组中的至少1种微生物。
15.一种阿尔茨海默病的评价方法,其包括下述工序:
(1)对被检者粪便中的微生物进行定量的工序;
(2)将工序(1)中进行定量而得到的值与对健康者粪便中的所述微生物进行定量而得到的对应值进行比较的工序;及
(3)在工序(2)的比较结果为被检者粪便中的所述定量值高于所述对应值时,判定所述被检者罹患了阿尔茨海默病的工序,
并且所述微生物为选自由属于副拟杆菌属的微生物组成的组中的至少1种微生物。
CN202180092790.9A 2020-12-03 2021-12-03 用于预防或治疗脑功能下降或者维持或改善脑功能的组合物 Pending CN116801735A (zh)

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