KR20230113365A

KR20230113365A - 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의유지 혹은 개선을 하기 위한 조성물

Info

Publication number: KR20230113365A
Application number: KR1020237021804A
Authority: KR
Inventors: 쇼지 신카이; 아키히코 기타무라; 다쿠지 야마다; 가즈나리 우시다; 사야카 츠치다; 아츠시 우에다; 노리유키 고우다; 다카히로 가리야; 도모히로 가와하라; 요다이 고바야시
Original assignee: 오츠카 세이야쿠 가부시키가이샤; 고쿠리츠다이가쿠호진 토쿄고교 다이가꾸
Priority date: 2020-12-03
Filing date: 2021-12-03
Publication date: 2023-07-28
Also published as: WO2022118944A1; JPWO2022118944A1; CN116801735A; TW202237159A; EP4260908A1

Abstract

인지증의 평가 방법, 및 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물을 제공하는 것을 과제로 하여, 정상인, 경도 인지 장애 환자, 및 알츠하이머병의 이환자의 장내 미생물총을 비교하였다. 그 결과, 인지 기능과 관련되는 장내 미생물로서, 패칼리박테리움속에 속하는 미생물 등을 선발하였다. 또한, 특정한 DNA를 갖는 패칼리박테리움 프라우스니치이가, 학습·기억 장애 등의 뇌 기능 저하에 대하여 개선 효과를 발휘하는 것을 밝혔다.

Description

뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물

본 발명은, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 미생물에 관한 것이다. 또한, 본 발명은, 상기 미생물, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 포함하는 조성물, 및 경도 인지 장애 또는 알츠하이머병의 평가 방법에 관한 것이다.

뇌는 척수와 함께 중추 신경계를 이루고, 인지, 운동, 생명 유지 등의 신경을 통한 활동의 중심적인 역할을 담당한다. 그 때문에, 그 기능의 저하는 일상 생활, 사회 생활에 있어서 엄청난 지장을 초래하게 된다. 특히, 근년의 급속한 고령화에 수반하여, 알츠하이머병(AD) 등, 나아가 그 전단계가 되는 경도 인지 장애(MCI)의 증가는 세계적인 문제로 되고 있으며, 그 예방, 치료 등에 유효한 방법의 개발이 희구되고 있다.

이러한 현상황에 있어서, 근년, 뇌와 장의 쌍방향적인 정보 전달(뇌장 상관)이 주목을 모으고 있고, 장내에 서식하는 미생물(장내 미생물, 장내 세균)이 그 숙주의 몸의 건강뿐만 아니라, 뇌의 기능에도 영향을 주고 있는 것이 밝혀져 있다.

예를 들어, AD 모델 마우스에 있어서, 항생 물질 투여에 의한 장내 미생물총의 변동이, 그 질환에 관여하는 뇌내 염증 및 아밀로이드 β량에 영향을 주는 것(비특허문헌 1), 장내 미생물총을 갖지 않는 무균의 AD 모델 마우스에 있어서는, 그 질환에 관여하는 뇌내 아밀로이드 β량이 저감되어 있는 것(비특허문헌 2)이 보고되어 있다. 또한, 인지증 환자와 정상인 사이에서 장내 미생물총을 비교한 결과, 전자에 있어서 박테로이데스량이 적어져 있는 것이 밝혀져 있다(비특허문헌 3).

또한, 패칼리박테리움 프라우스니치이에 있어서는, 래트에 있어서의 스트레스 유도성의 우울형 및 불안형 행동에 대하여, 예방 및 치료 효과를 나타내는 것도 명확해지고는 있다(비특허문헌 4). 그러나, 인지 기능 저하의 예방, 치료 및 증상 완화, 그리고 인지 기능의 유지 및 개선에 대해서는 보고되어 있지 않다.

Minter MR. 등, Sci Rep., 2016년 7월 21일, 6: 30028. Harach T. 등, Sci Rep., 2017년 2월 8일, 7: 41802. Saji N. 등, Sci Rep., 2019년 1월 30일, 9(1): 1008. Hao Z. 등, Psychoneuroendocrinology, 2019년 6월, 104권, 132 내지 142페이지

본 발명은, 뇌 기능의 저하에 대하여 유효한 장내 미생물을 알아내고, 당해 미생물을 유효 성분으로 하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물을 제공하는 데 있다. 또한, 본 발명은, 인지 기능 등의 뇌 기능과 관련되는 장내 미생물을 선발하고, 당해 미생물량을 지표로 하는 인지증의 평가 방법을 제공하는 것을 목적으로 한다.

본 발명자들은, 상기 목적을 달성하기 위해, 우선, 경도 인지 장애(MCI) 환자 또는 알츠하이머병(AD)의 이환자와 정상인 사이에 있어서의 장내 미생물총을 비교하였다. 그 결과, 숙주의 인지 기능과 관련되는 장내 미생물로서, 패칼리박테리움속에 속하는 미생물 등을 동정하기에 이르렀다.

보다 구체적으로는 패칼리박테리움속에 속하는 미생물, 루미노코커스과에 속하는 속명 불명의 미생물, 아나에로스티페스속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라속에 속하는 미생물, 및 루미노코커스속에 속하는 미생물의, 장내 미생물총에 있어서의 상대 존재량은, 정상인에 비해 MCI 환자는 낮고, 한편, 프레보텔라속에 속하는 미생물의 상대 존재량은, 정상인에 비해, MCI 환자는 높은 것을 알아내었다.

또한, 블라우티아속에 속하는 미생물, 푸시카테니박터속에 속하는 미생물, 루미노코커스속에 속하는 미생물, 및 유박테리움속에 속하는 미생물의 장내 미생물총에 있어서의 상대 존재량은, 정상인에 비해, AD 이환자는 낮고, 한편, 파라박테로이데스속에 속하는 미생물의 상대 존재량은, 정상인에 비해, AD 이환자는 높은 것도 알아내었다.

또한, 본 발명자들은, 패칼리박테리움속에 속하는 미생물(패칼리박테리움 프라우스니치이)주를, MCI 환자의 분변 시료로부터 1주, 정상인으로부터 11주, 각각 단리 배양하는 것에 성공하였다. 그리고, 그들을 AD 모델 마우스에 각각 투여하고, 당해 마우스에 있어서의 인지 기능 저하(학습·기억 장애)의 개선의 정도를, Y 미로 시험 및 수동 회피 시험을 사용하여 평가하였다. 그 결과, Fp14(수탁 번호 NITE BP-03169) 및 Fp360(NITE BP-03196)으로 특정되는 미생물의 2주에 개선 효과가 확인되었다.

또한, 상기 2주와, 기타 Fp주 10주의, 전체 게놈 서열을 비교한 결과, 서열 번호: 1 내지 57 및 422에 기재된 DNA 서열에 대응하는, 전자에 특유한 28의 유전자(오르토로그)를 선발할 수 있었다.

또한, Fp14와 기타 11주의 전체 게놈 서열을 비교한 결과, 서열 번호: 58 내지 207에 기재된 DNA 서열에 대응하는, 전자에 특유한 150의 오르토로그를 선발할 수 있었다.

또한, Fp360과 기타 11주의 전체 게놈 서열을 비교한 결과, 서열 번호: 208 내지 421에 기재된 DNA 서열에 대응하는, 전자에 특유한 214의 오르토로그를 선발할 수 있었다.

이와 같이, 뇌 기능 저하에 대하여 개선 효과를 발휘할 수 있는 Fp주에 특유한 DNA 서열(오르토로그)을 알아내고, 본 발명을 완성하기에 이르렀다.

즉, 본 발명은, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선에 유용한 Fp주, 당해 미생물의 성분, 당해 미생물의 배양물, 또는 그들 중 어느 것을 유효 성분으로서 포함하는 조성물, 그리고 숙주의 인지 기능과 관련되는 장내 미생물량을 지표로 하여, 인지증의 평가를 행하는 방법에 관한 것이고, 보다 상세하게는, 이하를 제공하는 것이다.

<1> 하기 (1) 내지 (28) 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물

(1) 서열 번호: 22 또는 46에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(2) 서열 번호: 21 또는 54에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(3) 서열 번호: 18 또는 55에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(4) 서열 번호: 9 또는 30에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(5) 서열 번호: 19 또는 33에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(6) 서열 번호: 17 또는 34에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(7) 서열 번호: 3 또는 43에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(8) 서열 번호: 6 또는 53에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(9) 서열 번호: 7 또는 35에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(10) 서열 번호: 2 또는 39에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(11) 서열 번호: 25 또는 41에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(12) 서열 번호: 23 또는 50에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(13) 서열 번호: 24 또는 45에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(14) 서열 번호: 26 또는 48에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(15) 서열 번호: 8 또는 40에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(16) 서열 번호: 4 또는 37에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(17) 서열 번호: 13 또는 38에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(18) 서열 번호: 16 또는 56에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(19) 서열 번호: 14 또는 57에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(20) 서열 번호: 27 또는 36에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(21) 서열 번호: 12 또는 42에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(22) 서열 번호: 15, 31 또는 49에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(23) 서열 번호: 5, 52 또는 51에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(24) 서열 번호: 20 또는 44에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(25) 서열 번호: 1 또는 32에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(26) 서열 번호: 11 또는 29에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(27) 서열 번호: 10 또는 47에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(28) 서열 번호: 28 또는 422에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA.

<2> 상기 패칼리박테리움 프라우스니치이가, 상기 (1) 내지 (28)의 28의 DNA를 갖는 패칼리박테리움 프라우스니치이인, <1>에 기재된 조성물.

<3> 하기 (1) 내지 (3) 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:

(3) 서열 번호: 18 또는 55에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA.

<4> 상기 패칼리박테리움 프라우스니치이가, 상기 (1) 내지 (3)에 기재된 3의 DNA를 갖는 패칼리박테리움 프라우스니치이인, <3>에 기재된 조성물.

<5> 하기 DNA군에서 선택되는 적어도 1의 DNA를 갖는, 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:

서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA로 이루어지는 군(단, 서열 번호: N에 관한 뉴클레오티드 서열은, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열이다. N은 58 내지 207 중 어느 것이다).

<6> 하기 DNA군에서 선택되는 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:

서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA로 이루어지는 군(단, 서열 번호: N에 관한 뉴클레오티드 서열은, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열이다. N은 208 내지 421 중 어느 것이다).

<7> 상기 뇌 기능이 인지 기능인, <1> 내지 <6> 중 어느 한 항에 기재된 조성물.

<8> 식품 조성물인, <1> 내지 <6> 중 어느 한 항에 기재된 조성물.

<9> 의약 조성물인, <1> 내지 <6> 중 어느 한 항에 기재된 조성물.

<10> 수탁 번호 NITE BP-03169로 특정되는 미생물.

<11> 수탁 번호 NITE BP-03196으로 특정되는 미생물.

본 발명은 또한, 상기 조성물을 제조하기 위한, 상기 패칼리박테리움 프라우스니치이, 상기 수탁 번호 NITE BP-03169로 특정되는 미생물, 상기 수탁 번호 NITE BP-03196으로 특정되는 미생물, 이들 미생물의 성분, 또는 이들 미생물의 배양물의 사용에 관한 것이다.

본 발명은 또한, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한, 상기 패칼리박테리움 프라우스니치이, 상기 수탁 번호 NITE BP-03169로 특정되는 미생물, 상기 수탁 번호 NITE BP-03196으로 특정되는 미생물, 이들 미생물의 성분, 또는 이들 미생물의 배양물의 사용에 관한 것이다.

본 발명은 또한, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선에 사용하기 위한, 상기 패칼리박테리움 프라우스니치이, 상기 수탁 번호 NITE BP-03169로 특정되는 미생물, 상기 수탁 번호 NITE BP-03196으로 특정되는 미생물, 이들 미생물의 성분, 또는 이들 미생물의 배양물에 관한 것이다.

본 발명은 또한, 상기 패칼리박테리움 프라우스니치이, 상기 수탁 번호 NITE BP-03169로 특정되는 미생물, 상기 수탁 번호 NITE BP-03196으로 특정되는 미생물, 이들 미생물의 성분, 또는 이들 미생물의 배양물 유효량을, 대상에 투여하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 방법에 관한 것이다.

또한, 본 발명은, 숙주의 인지 기능과 관련되는 장내 미생물량을 지표로 하여, 인지증의 평가를 행하는 방법에 관한 것이고, 보다 상세하게는, 이하를 제공하는 것이다.

<12> 경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 미생물을 정량하여 얻어지는 대응값과 비교하는 공정, 및

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 미생물이, 패칼리박테리움속에 속하는 미생물, 아나에로스티페스속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라속에 속하는 미생물, 및 루미노코커스속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.

<13> 경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 높은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 미생물이 프레보텔라속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.

<14> 알츠하이머병의 평가 방법이며,

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 알츠하이머병을 이환하고 있다고 판정하는 공정을 포함하며, 또한 상기 미생물이, 블라우티아속에 속하는 미생물, 푸시카테니박터속에 속하는 미생물, 루미노코커스속에 속하는 미생물, 및 유박테리움속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.

<15> 알츠하이머병의 평가 방법이며,

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 높은 경우에, 상기 피검자는 알츠하이머병을 이환하고 있다고 판정하는 공정을 포함하며, 또한 상기 미생물이, 파라박테로이데스속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.

<16> 경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 DNA를 정량하는 공정,

(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 DNA를 정량하여 얻어지는 대응값과 비교하는 공정, 및

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다 낮은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 DNA가 하기 (a) 내지 (i) 중 적어도 1의 DNA인, 방법

(a) 서열 번호: 22 또는 46에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(b) 서열 번호: 158에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(c) 서열 번호: 204에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(d) 서열 번호: 205에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(e) 서열 번호: 206에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(f) 서열 번호: 365에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(g) 서열 번호: 414에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(h) 서열 번호: 420에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,

(i) 서열 번호: 421에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA.

<17> 경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 DNA를 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다 높은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 DNA가, 서열 번호: 297에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA인, 방법.

본 발명에 따르면, 특정한 DNA 서열을 갖는 패칼리박테리움 프라우스니치이주를 투여함으로써, 대상의 뇌 기능의 저하, 특히 인지 기능의 저하를, 예방 또는 치료하는 것이 가능해진다. 또한, 대상의 뇌 기능, 특히 인지 기능을 유지 또는 개선하는 것도 가능해진다.

또한, 본 발명에 따르면, 장내 미생물량을 지표로 하여, 인지증, 경도 인지 장애, 혹은 그 전단계의 진단을 행하는 것이 가능해진다. 특히, 본 발명에 있어서는, 그 존재량이 경도 인지 장애 및 알츠하이머병 각각과 상관되는 장내 미생물을 동정하고 있으며, 이들 장내 미생물은 인지증의 진단 유효한 지표가 된다.

도 1은 정상인과 경도 인지 장애(MCI) 환자에 있어서, 장내 미생물총을 비교한 결과를 나타내는 볼케이노-플롯도이다. 도면 중, X축은, 정상인에 있어서의 각 장내 미생물의 존재량(abundance)의 중앙값에 대한 MCI 환자의 그것의 비를 log₂로 변환한 값을 나타내고, Y축은, 윌콕슨의 순위합 검정에 의해 산출한 P값을 -log₁₀으로 변환한 값을 나타낸다. 또한, 도면 중의 써클의 사이즈는, 각 장내 미생물의 존재량의 중앙값을 나타낸다.
도 2는 정상인과 알츠하이머병(AD) 이환자에 있어서, 장내 미생물총을 비교한 결과를 나타내는 볼케이노-플롯도이다. 도면 중의 표기에 대해서는 「MCI 환자」를 「AD 이환자」로 치환하는 이외에는, 도 1과 마찬가지이다.
도 3은 아밀로이드 β를 뇌실내에 투여한 마우스에, 각 패칼리박테리움 프라우스니치이(Fp)주(모두 생균)를 단기간(11일간) 경구 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, Y 미로 시험을 사용하여 평가한 결과를 나타내는 그래프이다. 도면 중, 횡축은 투여한 각 Fp주 및 대조 물질 등을 나타내고, 종축은 자발적 교체 행동율(Alteration rate)을 나타낸다. 각 데이터는 평균값+표준 오차(SEM)를 나타낸다. 「**」은 스튜던트 t 검정의 결과, 대조군 1(허위 수술)과 비교하여 P<0.01인 것을 나타낸다. 「＃」 및 「＃＃」은 스튜던트 t 검정의 결과, 대조군 3(배양 배지 투여)과 비교하여 P<0.05 및 P<0.01인 것을 각각 나타낸다. 「††」(대거(Dagger) 2개)는 스튜던트 t 검정의 결과, 대조군 2(생리 식염액 투여)와 비교하여 P<0.01인 것을 나타낸다.
도 4는 아밀로이드 β 뇌실내 투여 마우스에, 각 Fp주(모두 생균)를 단기간(11일간) 경구 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, 수동 회피 시험을 사용하여 평가한 결과를 나타내는 그래프이다. 도면 중, 횡축은 투여한 각 Fp주 및 대조 물질 등을 나타내고, 종축은 반응 잠복 시간(Latency time)을 나타낸다. 각 데이터는 평균값+표준 오차(SEM)를 나타낸다. 「**」은 스튜던트 t 검정의 결과, 대조군 1(허위 수술)과 비교하여 P<0.01인 것을 나타낸다. 「＃」은 스튜던트 t 검정의 결과, 대조군 3(배양 배지 투여)과 비교하여 P<0.05인 것을 나타낸다. 「††」(대거 2개)은 스튜던트 t 검정의 결과, 대조군 2(생리 식염수 투여)와 비교하여 P<0.01인 것을 나타낸다.
도 5는 아밀로이드 β 뇌실내 투여한 마우스에, 각 Fp주를 단기간(11일간) 경구 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, Y 미로 시험을 사용하여 평가한 결과를 나타내는 그래프이다. 도면 중, 「live」, 「pasteurized」 및 「sup」는, 각 균주의 생균, 사균체 및 배양 상청을 각각 투여한 결과를 나타낸다. 다른 도면 중의 표기에 대해서는, 도 3과 마찬가지이다.
도 6은 아밀로이드 β 뇌실내 투여 마우스에, 각 Fp주를 단기간(11일간) 경구 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, 수동 회피 시험을 사용하여 평가한 결과를 나타내는 그래프이다. 도면 중, 「live」, 「pasteurized」 및 「sup」는, 각 균주의 생균, 사균체 및 배양 상청을 각각 투여한 결과를 나타낸다. 다른 도면 중의 표기에 대해서는, 도 4와 마찬가지이다.
도 7은 Fp주간에 있어서 전체 게놈을 비교 해석하기 위해 사용한 파이프라인의 개요를 나타내는 차트도이다.
도 8은 3오르토로그(OG0003538, OG0003537 및 OG0003536)는, Fp14 및 Fp360을 특징짓는 유니크한 유전자이며, 이들은 게놈 상에 있어서 인접하게 배치되어 있는 것을 나타내는, 개략도이다. 도면 중, 「2238」, 「2237」 및 「2236」은, 서열표 및 표 2에 기재된 「ICBIDGAJ_02238(서열 번호: 18)」, 「ICBIDGAJ_02237(서열 번호: 21)」 및 「ICBIDGAJ_02236(서열 번호: 22)」에 각각 대응한다. 「2132」, 「2133」 및 「2134」는, 서열표 및 표 2에 기재된 「BLCPAMOF_02132(서열 번호: 55)」, 「BLCPAMOF_02133(서열 번호: 54)」 및 「BLCPAMOF_02134(서열 번호: 46)」에 각각 대응한다. 「2236」 및 「2134」에 첨부된 「*」은, 윌콕슨의 순위합 검정의 결과, 이들 오르토로그의 상대 존재량이 정상인군과 비교하여 MCI군에서 유의미하게 낮은(P<0.05) 것을 나타낸다.
도 9는 Fp14를 특징짓는 유니크한 12 유전자가, 게놈 상에 있어서 인접하게 배치되어 있는 것을 나타내는 개략도이다. 「778」, 「768」 및 「767」은, 서열표에 기재된 「ICBIDGAJ_00778(서열 번호: 162)」, 「ICBIDGAJ_00768(서열 번호: 198)」 및 「ICBIDGAJ_00767(서열 번호: 203)」에 각각 대응하는 세포외 단백질로 추정된 오르토로그이다. 「777」 내지 「769」은, 서열표에 기재된 「ICBIDGAJ_00777(서열 번호: 192)」, 「ICBIDGAJ_00776(서열 번호: 191)」, 「ICBIDGAJ_00775(서열 번호: 190)」, 「ICBIDGAJ_00774(서열 번호: 189)」, 「ICBIDGAJ_00773(서열 번호: 188)」, 「ICBIDGAJ_00772(서열 번호: 187)」, 「ICBIDGAJ_00771(서열 번호: 186)」, 「ICBIDGAJ_00770(서열 번호: 185)」 및 「ICBIDGAJ_00769(서열 번호: 59)」에 각각 대응하는 막 관통 단백질로 추정된 오르토로그이다. 또한, 도면 중, 825000 부근의 번호가 첨부되지 않은 흑색칠한 2개의 오르토로그는 모두, 세포외 단백질로 추정된, Fp14 비특유의 오르토로그이다.
도 10은 Fp14를 특징짓는 유니크한 5 유전자가, 게놈 상에 있어서 인접하게 배치되어 있는 것을 나타내는 개략도이다. 도면 중, 「757」 및 「756」은, 서열표에 기재된 「ICBIDGAJ_00757(서열 번호: 159)」 및 「ICBIDGAJ_00756(서열 번호: 158)」에 각각 대응한다. 트레할로오스 관련 KO인, 「755」, 「754」 및 「753」은, 서열표에 기재된 「ICBIDGAJ_00755(서열 번호: 205)」, 「ICBIDGAJ_00754(서열 번호: 204)」 및 「ICBIDGAJ_00753(서열 번호: 206)」에 대응한다. 또한, 「757」은 세포내 단백질로 추정된 오르토로그이며, 「756」, 「755」 및 「753」은 각각, 세포외 단백질로 추정된 오르토로그이며, 「754」는 막 관통 단백질로 추정된 오르토로그이다. 그 밖의 흑색칠한 오르토로그는 모두, Fp14 비특유의 오르토로그이다. 「750」 내지 「756」에 첨부된 「*」은, 윌콕슨의 순위합 검정의 결과, 이들 오르토로그의 상대 존재량이 정상인군과 비교하여 MCI군에서 유의미하게 낮은(P<0.05) 것을 나타낸다.
도 11은 Fp14를 장기간(13개월간) 경구 투여한 AD 모델 마우스의 뇌 조직에 있어서의, 노인반 점유율(％)을 나타내는 그래프이다. 도면 중, 횡축은 경구 투여한 물질을 나타내고, 또한 「C&H」, 「C」 및 「H」는 각각 「대뇌 피질 및 해마」, 「대뇌 피질」, 그리고 「해마」를 해석한 결과를 나타낸다. 각 데이터는 평균값+표준 오차(SEM)를 나타낸다. 도면 중에 부기한 P값은 스튜던트 t 검정으로 산출하였다.

(패칼리박테리움 프라우스니치이)

후술하는 실시예에 나타내는 대로, 후술하는 본 발명에 관한 DNA 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이주를 투여함으로써, 대상의 뇌 기능의 저하가 개선되는 것이, 본 발명자들에 의해 명확해졌다. 따라서, 본 발명은, 특정한 DNA 서열을 갖는 패칼리박테리움 프라우스니치이에 관한 것이다.

「패칼리박테리움 프라우스니치이(Faecalibacterium prausnitzii)」란, 일반적으로 후벽균(Firmicutes)문 클로스트리디아(Clostridia)강 에우박테리알레스(Eubacteriales)목 오스실로스피라세아에(Oscillospiraceae)과 패칼리박테리움 (Faecalibacterium)속에 속하는, 혐기성이며 그람 음성의 간균을 의미한다. 당해 미생물(세균)은 아포를 형성하지 않고, 또한 아세트산으로부터 부티르산을 생성한다는 특징을 갖는다. 또한, 패칼리박테리움 프라우스니치이에는, 예를 들어 형태적 특징(예를 들어, 콜로니의 형상, 세포의 형 등), 생리, 생화학 성상(예를 들어, 당의 자화성, 생육 온도, 최적 pH 등), 화학 분류학적 성상(균체 지방산 조성 등) 등의 성상을, 기지의 패칼리박테리움 프라우스니치이와 비교하여, 그 성상에 1 비교 결과에 기초하여 동일하거나 또는 실질적으로 동일하다고 동정된 미생물도 포함할 수 있다. 또한, 16SrRNA 유전자의 뉴클레오티드 서열의 해석에 기초하여 동일하거나 또는 실질적으로 동일하다고 동정된 미생물도 포함될 수 있다.

보다 구체적으로는 기지의 패칼리박테리움 프라우스니치이와 동일하거나 또는 실질적으로 동일하다고 동정된 미생물은, 동속의 미생물이며, 16SrRNA 유전자의 염기 서열이, 기지의 패칼리박테리움 프라우스니치이 중 어느 미생물의 16SrRNA 유전자의 염기 서열과 97％ 이상, 바람직하게는 98％ 이상, 보다 바람직하게는 99％ 이상, 보다 바람직하게는 100％의 상동성을 가지며, 또한 바람직하게는 기지의 패칼리박테리움 프라우스니치이 중 어느 미생물과 어느 동일한 미생물학적 성질(균학적 성질)을 갖는다.

또한, 본 발명의 효과가 손상되지 않는 한, 기지의 패칼리박테리움 프라우스니치이의 각 미생물로부터, 변이 처리, 유전자 재조합, 자연변이주의 선택 등에 의해 육종된 미생물이어도 된다. 이러한 「변이주」는, 특정한 미생물(균주)에 대하여, 당업자에게 주지된 방법에 의해 당업자가 그 성질에 변화를 미치게 하지 않는 범위에서 변이시킨 것, 자연 변이주의 선택 등에 의해 육종된 것, 혹은 그것과 동등하다고 당업자가 확인할 수 있는 것을 포함하는 것을 의미한다.

또한, 기지의 패칼리박테리움 프라우스니치이에는, 당해 균주명으로 소정의 기관에 기탁나 등록이 이루어져 있는 주 그 자체(이하, 「기탁주」라고도 함)에 한정되지 않고, 그것과 실질적으로 동등한 주(「파생주」 또는 「유도주」 라고도 함)도 포함된다.

균주에 대해서, 「기탁주와 실질적으로 동등한 주」란, 기탁주와 동일한 종에 속하고, 본 발명의 효과를 발휘할 수 있는 주를 의미한다. 기탁주와 실질적으로 동등한 주는, 예를 들어 당해 기탁주를 친주로 하는 파생주이면 된다. 파생주로서는, 기탁주로부터 육종된 주나 기탁주로부터 자연스럽게 발생한 주를 들 수 있다.

실질적으로 동일한 균주, 파생주는 하기와 같은 주를 들 수 있다.

(1) RAPD법(Randomly Amplified Polymorphic DNA), PFGE법(Pulsed-field gel electrophoresis)법에 의해 동일한 균주라고 판정되는 균주(Probiotics in food/Health and nutritional properties and guidelines for evaluation 85 Page43에 기재)

(2) 당해 기탁균주 유래의 유전자만 보유하고, 외래 유래의 유전자를 갖지 않고, DNA의 상동성이 97％ 이상(적합하게는 98％ 이상)인 균주

(3) 당해 균주로부터 육종된 주(유전자 공학적 개변, 돌연변이, 자연 돌연변이를 포함함), 동일한 형질을 갖는 주.

「본 발명에 관한 패칼리박테리움 프라우스니치이」는, 전술한 일반적인 패칼리박테리움 프라우스니치이에 있어서, 하기 본 발명에 관한 DNA군 중 적어도 1의 DNA를 갖는 미생물이다.

후술하는 실시예에 나타내는 대로, 뇌 기능의 저하에 대하여 개선 효과가 확인된 Fp14 및 Fp360에 특유한 28의 오르토로그에 대응하는 서열로서, 서열 번호: 1 내지 57 및 422에 기재된 DNA 서열이 추출되어 있다. 따라서, 본 발명에 관한 DNA군으로서는, 하기 (1) 내지 (28)에 기재된 DNA로 이루어지는 군을 들 수 있다.

상기 (1) 내지 (28)에 기재된 DNA 중, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 바람직하게는 2 이상(예를 들어, 3 이상, 4 이상), 보다 바람직하게는 5 이상(예를 들어, 6 이상, 7 이상, 8 이상, 9 이상), 더욱 바람직하게는 10 이상(예를 들어, 11 이상, 12 이상, 13 이상, 14 이상), 보다 바람직하게는 15 이상(예를 들어, 16 이상, 17 이상, 18 이상, 19 이상), 더욱 바람직하게는 20 이상(예를 들어, 21 이상, 22 이상, 23 이상, 24 이상), 보다 바람직하게는 25 이상(예를 들어, 26 이상, 27 이상), 특히 바람직하게는 28의 DNA를 갖는 미생물(즉, 상기 (1) 내지 (28)에 기재된 28의 DNA를 갖는 패칼리박테리움 프라우스니치이)이다.

본 발명에 관한 패칼리박테리움 프라우스니치이는 또한, 상기 (1) 내지 (3) 중 적어도 1의 DNA를 갖는 미생물인 것이 바람직하고, 상기 (1) 내지 (3) 중 적어도 2의 DNA를 갖는 미생물인 것이 보다 바람직하고, 상기 (1) 내지 (3)에 기재된 3의 DNA를 갖는 미생물인 것이 더욱 바람직하다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 상기 (1)에 기재된 DNA를 적어도 갖는 미생물인 것이 바람직하다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 상기 (1) 내지 (28) 중 적어도 1의 DNA, 상기 (1) 내지 (3) 중 적어도 1의 DNA, 또는 상기 (1)에 기재된 DNA에 더하여, 후술하는, 서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA군, 및/또는 서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA군에서 선택되는, 적어도 1의 DNA를 포함하고 있어도 된다.

후술하는 실시예에 나타내는 대로, 뇌 기능의 저하에 대하여 개선 효과가 확인된 Fp14에만 특유한 150의 오르토로그에 대응하는 서열로서, 서열 번호: 58 내지 207에 기재된 DNA 서열이 추출되어 있다. 따라서, 본 발명에 관한 DNA군으로서는, 하기 DNA군을 들 수 있다.

서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA군(단, 서열 번호: N에 관한 뉴클레오티드 서열이란, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 의미한다. 여기에서의 「N」은 58 내지 207 중 어느 것이다).

상기 서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA군 중, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 바람직하게는 2 이상(예를 들어, 3 이상, 4 이상), 보다 바람직하게는 5 이상(예를 들어, 6 이상, 7 이상, 8 이상, 9 이상), 더욱 바람직하게는 10 이상, 보다 바람직하게는 20 이상, 더욱 바람직하게는 30 이상, 보다 바람직하게는 40 이상, 더욱 바람직하게는 50 이상, 보다 바람직하게는 60 이상, 더욱 바람직하게는 70 이상, 보다 바람직하게는 80 이상, 더욱 바람직하게는 90 이상, 보다 바람직하게는 100 이상, 더욱 바람직하게는 110 이상, 보다 바람직하게는 120 이상, 더욱 바람직하게는 130 이상, 보다 바람직하게는 140 이상(예를 들어, 141 이상, 142 이상, 143 이상, 144 이상, 145 이상, 146 이상, 147 이상, 148 이상, 149 이상), 특히 바람직하게는 150의 DNA를 갖는 미생물이다.

본 발명에 관한 패칼리박테리움 프라우스니치이는 또한, 서열 번호: 158 및 204 내지 206에 관한 뉴클레오티드 서열을 각각 포함하는 4의 DNA로 이루어지는 군에서 선택되는, 적어도 1의 DNA를 갖고, 바람직하게는 2 이상의 DNA를 갖고, 보다 바람직하게는 3 이상의 DNA를 갖고, 더욱 바람직하게는 4의 DNA를 갖는 미생물이다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA군, 또는 서열 번호: 158 및 204 내지 206에 관한 뉴클레오티드 서열을 각각 포함하는 4의 DNA군에서 선택되는, 적어도 1의 DNA에 더하여, 상기 (1) 내지 (28) 중 적어도 1의 DNA, 상기 (1) 내지 (3) 중 적어도 1의 DNA, 또는 상기 (1)에 기재된 DNA를 포함하고 있어도 된다.

후술하는 실시예에 나타내는 대로, 뇌 기능의 저하에 대하여 개선 효과가 확인된 Fp360에만 특유한 214의 오르토로그에 대응하는 서열로서, 서열 번호: 208 내지 421에 기재된 DNA 서열이 추출되어 있다. 따라서, 본 발명에 관한 DNA군으로서는, 하기 DNA군을 들 수 있다.

서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA군(단, 서열 번호: N에 관한 뉴클레오티드 서열이란, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 의미한다. 여기에서의 「N」은 208 내지 421 중 어느 것이다).

상기 서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA군 중, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 바람직하게는 2 이상(예를 들어, 3 이상, 4 이상), 보다 바람직하게는 5 이상(예를 들어, 6 이상, 7 이상, 8 이상, 9 이상), 더욱 바람직하게는 10 이상, 보다 바람직하게는 20 이상, 더욱 바람직하게는 30 이상, 보다 바람직하게는 40 이상, 더욱 바람직하게는 50 이상, 보다 바람직하게는 60 이상, 더욱 바람직하게는 70 이상, 보다 바람직하게는 80 이상, 더욱 바람직하게는 90 이상, 보다 바람직하게는 100 이상, 더욱 바람직하게는 110 이상, 보다 바람직하게는 120 이상, 더욱 바람직하게는 130 이상, 보다 바람직하게는 140 이상, 더욱 바람직하게는 150 이상, 보다 바람직하게는 160 이상, 더욱 바람직하게는 170 이상, 보다 바람직하게는 180 이상, 더욱 바람직하게는 190 이상, 보다 바람직하게는 200 이상(예를 들어, 201 이상, 202 이상, 203 이상, 204 이상), 더욱 바람직하게는 205 이상(예를 들어, 206 이상, 207 이상, 208 이상, 209 이상), 보다 바람직하게는 210 이상(예를 들어, 211 이상, 212 이상, 213 이상), 특히 바람직하게는 214의 DNA를 갖는 미생물이다.

본 발명에 관한 패칼리박테리움 프라우스니치이는 또한, 서열 번호: 365, 414, 420 및 421에 관한 뉴클레오티드 서열을 각각 포함하는 4의 DNA로 이루어지는 군에서 선택되는, 적어도 1의 DNA를 갖고, 바람직하게는 2 이상의 DNA를 갖고, 보다 바람직하게는 3 이상의 DNA를 갖고, 더욱 바람직하게는 4의 DNA를 갖는 미생물이다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA로 이루어지는 군, 또는 서열 번호: 365, 414, 420 및 421에 관한 뉴클레오티드 서열을 각각 포함하는 4의 DNA군에서 선택되는, 적어도 1의 DNA에 더하여, 상기 (1) 내지 (28) 중 적어도 1의 DNA, 상기 (1) 내지 (3) 중 적어도 1의 DNA, 또는 상기 (1)에 기재된 DNA를 포함하고 있어도 된다.

또한, 본 발명에 있어서, 본 발명에 관한 DNA는, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열 외에도, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 있어서, 1개 또는 복수의 아미노산이 치환, 결실, 부가 및/또는 삽입된 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA, 또는 서열 번호: N에 기재된 뉴클레오티드 서열을 포함하는 DNA와 엄격한 조건 하에서 하이브리다이징하는 DNA의 양태도 취할 수 있다(여기에서의 N은 1 내지 422 중 적어도 1의 번호이다).

「상동성」이란, 유사성(similarity) 또는 동일성(identity)을 의미할 수 있다. 또한, 「상동성」이란, 특히 동일성(identity)을 의미해도 된다. 아미노산 서열의 상동성은, BLAST(Basic Local Alignment Search Tool at the National Center for Biological Information(미국 국립 생물학 정보 센터의 기본 로컬 얼라인먼트 검색 툴)) 등의 얼라인먼트 프로그램을 이용하여 결정할 수 있다. 예를 들어, 아미노산 서열의 상동성이란, blastp를 사용하여 산출되는 아미노산 서열간의 상동성을 들 수 있고, 보다 구체적으로는 blastp를 디폴트의 파라미터를 사용하여 (즉, 초기 설정의 파라미터를 사용하여) 산출되는 아미노산 서열간의 상동성을 들 수 있다.

본 발명에 관한 아미노산 서열의 「상동성」은 40％ 이상이며, 바람직하게는 50％ 이상, 보다 바람직하게는 60％ 이상, 더욱 바람직하게는 70％ 이상, 보다 바람직하게는 80％ 이상, 더욱 바람직하게는 85％ 이상(예를 들어, 86％ 이상, 87％ 이상, 88％ 이상, 89％ 이상), 보다 바람직하게는 90％ 이상(예를 들어, 91％ 이상, 92％ 이상, 93％ 이상, 94％ 이상), 더욱 바람직하게는 95％ 이상(예를 들어, 96％ 이상, 97％ 이상, 98％ 이상, 99％ 이상), 특히 바람직하게는 100％이다.

본 발명에 있어서, 치환 등 되는 아미노산수로서는, 각 서열 번호에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열을 포함하는 폴리펩티드가, 당해 치환 등에 의해, 그 기능, 활성을 손상시키지 않는 한, 특별히 제한은 없고, 예를 들어 1000아미노산 이내(보다 구체적으로 900아미노산 이내, 800아미노산 이내, 700아미노산 이내, 600아미노산 이내), 500아미노산 이내(보다 구체적으로 400아미노산 이내, 300아미노산 이내, 200아미노산 이내), 100아미노산 이내(보다 구체적으로 90아미노산 이내, 80아미노산 이내, 70아미노산 이내, 60아미노산 이내), 50아미노산 이내(보다 구체적으로 40아미노산 이내, 30아미노산 이내, 20아미노산 이내), 10아미노산 이내(보다 구체적으로 9아미노산 이내, 8아미노산 이내, 7아미노산 이내, 6아미노산 이내, 5아미노산 이내, 4아미노산 이내, 3아미노산 이내, 2아미노산 이내, 1아미노산)이다.

아미노산의 치환 등은, 바람직하게는 보존적인 치환이다. 「보존적인 치환」이란, 화학적으로 마찬가지의 측쇄를 갖는 다른 아미노산 잔기로 치환하는 것을 의미한다. 화학적으로 마찬가지의 아미노산 측쇄를 갖는 아미노산 잔기의 그룹은, 본 발명이 속하는 기술 분야에서 잘 알려져 있다. 예를 들어, 산성 아미노산(아스파르트산·글루탐산), 염기성 아미노산(리신·아르기닌·히스티딘), 중성 아미노산에 있어서는, 탄화수소쇄를 갖는 아미노산(글리신·알라닌·발린·류신·이소류신·프롤린), 히드록시기를 갖는 아미노산(세린·트레오닌), 황을 포함하는 아미노산(시스테인·메티오닌), 아미드기를 갖는 아미노산(아스파라긴·글루타민), 이미노기를 갖는 아미노산(프롤린), 방향족기를 갖는 아미노산(페닐알라닌·티로신·트립토판)으로 분류할 수 있다.

「엄격한 조건」으로서는, 예를 들어 「1XSSC, 0.1％ SDS, 37℃」 정도의 하이브리다이제이션의 조건이며, 보다 엄격한 조건으로서는 「0.5XSSC, 0.1％ SDS, 42℃」 정도의 하이브리다이제이션의 조건이며, 더욱 엄격한 조건으로서는 「0.2XSSC, 0.1％ SDS, 65℃」 정도의 하이브리다이제이션의 조건을 들 수 있다.

본 발명에 관한 패칼리박테리움 프라우스니치이는, 당업자라면 공지된 방법에 기초하여 적절히 조제할 수 있다. 예를 들어, 인간, 비인간 포유 동물(예를 들어, 돼지 및 소 등의 우제류, 쥐 등의 설치류), 가금, 바퀴 등의 소화관 내용물(분변 등)을, 후술하는 실시예에 나타내는 대로, 혐기성 조건 하에 공지된 배지(예를 들어, YCFA 배지, EG 배지, LYBHI 배지)에서 배양함으로써 조제할 수 있다.

또한, 후술하는 실시예에 있어서 나타내는 대로, Fp14 및 Fp360은 본 발명에 관한 패칼리박테리움 프라우스니치이의 특히 바람직한 양태이며, Fp14는 2020년 3월 6일자로, 독립 행정법인 제품 평가 기술기반 기구 특허 미생물 기탁 센터(NITE, 우편 292-0818 지바현 기사라즈시 가즈사 가마타리 2-5-8122호실)에 기탁되어 있다(식별의 표시: Fp_0014, 수탁 번호: NITE BP-03169). Fp360은 2020년 4월 7일자로, 독립 행정 법인 제품 평가 기술 기반 기구 특허 미생물 기탁 센터에 기탁되어 있다(식별의 표시: Fp_0360, 수탁 번호: NITE BP-03196). 따라서, 이들 균주는 상기 기탁 센터에 신청함으로써 취득할 수 있다.

또한, 상술한 바와 같이, 본 발명에 관한 패칼리박테리움 프라우스니치이에는 Fp14 및/또는 Fp360과 동일하거나 또는 실질적으로 동일하다고 동정된 미생물, 즉, 본 발명의 효과가 손상되지 않는 한, 상기 수탁 번호에 의해 특정되는 각 기탁주에 특정되지 않고, 그 변이주, 파생주, 유도주도 포함될 수 있다. 보다 구체적으로는 Fp14 및 Fp360과 동속의 미생물이며, 16SrRNA 유전자의 염기 서열이, Fp14 및/또는 Fp360에 16SrRNA 유전자의 염기 서열과 97％ 이상, 바람직하게는 98％ 이상, 보다 바람직하게는 99％ 이상, 보다 바람직하게는 100％의 상동성을 가지며, 또한 바람직하게는 이들 미생물 중 어느 것과 어느 동일한 미생물학적 성질(균학적 성질)을 갖는 미생물을 들 수 있다.

또한 마찬가지로, 본 발명에 있어서, 상술한 본 발명에 관한 DNA군 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이의 변이주, 파생주, 유도주여도 된다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이는, 뇌 기능의 저하에 대하여 치료 및 예방 효과를 갖는 것이며, 또한 뇌 기능의 유지 작용 및 개선 작용을 갖는 것이다. 당해 미생물이 이러한 효과 또는 작용을 갖는지는, 예를 들어 후술하는 실시예에 나타내는 바와 같이, 뇌 기능이 저하되어 있는 비인간 동물을 사용한 행동 시험에 의해 평가할 수 있다. 보다 구체적으로는 뇌 기능이 저하되어 있는 비인간 동물(예를 들어, 알츠하이머병 모델 동물)에 상기 미생물을 투여하고, 그것을 투여하지 않았을 경우와 비교하여, 뇌 기능의 개선이 확인되었을 경우에, 상기 미생물은 상기 효과 및 작용을 갖는다고 판단할 수 있다. 또한, 뇌 기능의 평가는, 당업자라면 평가하고자 하는 뇌 기능에 맞게 공지된 행동 시험을 선택하여 행할 수 있다.

본 발명에 관한 패칼리박테리움 프라우스니치이는, 뇌내에 있어서의 아밀로이드 β의 축적을 억제하는 작용을 갖고 있는 것이 바람직하다. 본 발명에 관한 「아밀로이드 β」는, 막 단백질인 아밀로이드 β 전구체 단백질(APP)로부터 β 세크레타제 및 γ 세크레타제에 의해 절단되어 산생되는 36 내지 43아미노산을 포함하는 펩티드이다. 바람직하게는, 42아미노산을 포함하는 펩티드(아밀로이드 β42), 40아미노산을 포함하는 펩티드(아밀로이드 β40)이며, 보다 바람직하게는 아밀로이드 β42이다. 또한, 축적하는 아밀로이드 β의 형태로서는 특별히 제한은 없고, 모노머여도 되고, 올리고머를 형성하고 있어도 되고(아밀로이드 β 올리고머), 섬유화되어 있어도 되고(아밀로이드 섬유), 또는 이들이 혼합되어 있는 것이어도 된다.

아밀로이드 β는 알츠하이머병의 발증·진행에 관여하고 있다고 생각되고 있기 때문에, 그 축적을 억제하는 작용을 갖는 패칼리박테리움 프라우스니치이는, 당해 질환에 대한 우수한 예방 등의 효과를 발휘할 수 있다. 당해 미생물이 이러한 작용을 갖는지는, 예를 들어 후술하는 실시예에 나타내는 바와 같이, 알츠하이머병 모델 동물을 사용한 시험에 의해 평가할 수 있다. 보다 구체적으로는 알츠하이머병 모델 동물에 상기 미생물을 투여하고, 그것을 투여하지 않았을 경우와 비교하여, 뇌내에 있어서의 아밀로이드 β량이 저감되어 있을 경우에, 상기 미생물은 뇌내에 있어서의 아밀로이드 β의 축적을 억제하는 작용을 갖는다고 판단할 수 있다.

<뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물>

후술하는 실시예에 나타내는 대로, 상술한 본 발명에 관한 패칼리박테리움 프라우스니치이를 투여함으로써, 대상의 뇌 기능의 저하가 억제된다. 따라서, 본 발명은, 본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 대상에 있어서의, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물을 제공한다.

본 발명의 조성물에 있어서 유효 성분으로서 함유되는 패칼리박테리움 프라우스니치이로서는, 상술한 바와 같지만, 생균이어도 사균체여도 되고, 생균 및 사균체의 양쪽이어도 된다. 「사균체」로서는, 예를 들어 가열 처리체, 소성 처리체, 증자(蒸煮) 처리체, 방사선(γ선 등) 조사 처리체, 효소 처리체, 약물(항생 물질 등) 처리체, 화학 물질(포르말린 등) 처리체, 초음파 처리체를 들 수 있다. 또한, 패칼리박테리움 프라우스니치이의 형태는 특별히 한정되지 않고, 액체 또는 고체 중 어느 것이어도 되지만, 당해 형태는 건조 형태(예를 들어 균말상 등)가, 제조 시나 보관 시의 취급이 용이한 관점에서 적합하다. 건조물은, 균체를 용매(물 등)에 분산시킨 현탁액을 건조시킴으로써 조제할 수 있다. 건조 방법은 특별히 제한은 없고, 예를 들어 분무 건조(스프레이 드라이)법, 동결 건조법을 들 수 있다. 멸균 방법은 특별히 제한은 없고, 레토르트 살균법, UHT 살균법, 공기 살균법, 가압 살균법, 고압 증기 멸균법, 건열 멸균법, 유통 증기 소독법, 전자파 살균법, 전자선 멸균법, 고주파 멸균법, 방사선 멸균법, 자외선 살균법, 산화에틸렌 가스 멸균법, 과산화수소 플라스마 멸균법, 화학적 살균법(알코올 살균법, 포르말린 고정법, 전해수 처리법) 등을 들 수 있다. 또한, 경우에 따라서는, 가열 등에 의한 살균 처리 전후, 혹은 건조 처리 전후에, 계면 활성제 처리, 마쇄·분쇄 처리, 효소 처리, 분획 처리 등을 행할 수도 있고, 이들 처리에 의해 얻어지는 것도, 본 발명의 조성물에 함유할 수 있다.

본 발명의 조성물에 있어서 유효 성분으로서 함유되는 패칼리박테리움 프라우스니치이는, 전술한 균체뿐만 아니라, 당해 미생물의 구성 물질, 즉 미생물 자체의 성분(소위, 균체 성분. 예를 들어, 당해 미생물을 구성하는, 아미노산, 펩티드, 핵산, 당, 지질, 비타민, 호르몬, 및 그들의 복합체, 나아가, 그들과 인·황 금속 원소의 복합체 등)이어도 된다.

또한, 본 발명의 조성물이 함유하는 유효 성분은, 본 발명에 관한 패칼리박테리움 프라우스니치이의 배양물이어도 된다. 배양물은 당해 미생물을 포함하는 것(증식한 당해 미생물을 포함하는 배양액, 고형 배지 등)이어도 되고, 당해 배양물의 형태는 특별히 한정되지 않고, 액체 또는 고체 중 어느 것이어도 되지만, 당해 형태는 건조 형태(예를 들어 배양 건조물 등)가, 제조 시나 보관 시의 취급이 용이한 관점에서 적합하다. 또한, 이러한 배양 건조물 등도, 당업자라면 상술한 건조 방법을 사용하여 적절히 조제할 수 있다.

본 발명의 조성물은 의약 조성물(의약품, 의약 부외품 등), 식품 조성물(음식품, 동물용 사료 등), 혹은 모델 동물 실험 등에 사용되는 시약의 형태일 수 있다.

본 발명에 있어서의 조성물은, 유효 성분인 패칼리박테리움 프라우스니치이의 형태(예를 들어, 생균, 사균체, 균체 성분)에 따라서, 공지된 제제학적 방법에 의해 제제화할 수 있다. 예를 들어, 캡슐제, 정제, 환제, 액제, 산제, 과립제, 세립제, 필름 코팅제, 펠릿제, 트로키제, 설하제, 저작제, 바칼제, 페이스트제, 시럽제, 현탁제, 엘릭시르제, 유제, 도포제, 연고제, 경고제, 찜질제, 경피 흡수형 제제, 로션제, 흡인제, 에어로졸제, 주사제, 좌제 등으로서, 경구적 또는 비경구적으로 사용할 수 있다. 본 발명은, 후술하는 실시예에 있어서 나타내는 대로, 경구에 의해 비침습적이면서 또한 간편하게 섭취시킬 수 있다. 즉, 본 발명의 조성물 바람직한 섭취의 방법은 경구에 의한 섭취이다.

이들 제제화에 있어서는, 약리학상 혹은 음식품으로서 허용되는 담체, 구체적으로는 생리 식염수, 멸균수, 배지, 식물유, 용제, 부형제, 기제, 유화제, 현탁제, 계면 활성제, 안정제, 향미제, 방향제, 비히클, 방부제, 결합제, 희석제, 등장화제, 무통화제, 증량제, 붕괴제, 완충제, 코팅제, 활택제, 착색제, 감미제, 점조제, 교미 교취제, 용해 보조제 혹은 기타 첨가제 등과 적절히 조합할 수 있다.

본 발명의 조성물을 의약 조성물로서 사용하는 경우에는, 뇌 기능 저하에 대한 개선 등에 사용되는 공지된 물질과 병용해도 된다. 이러한 공지된 물질로서는, 예를 들어 인지증약, 보다 구체적으로는 콜린에스테라아제 저해약(도네페질 등), 아세틸콜린에스테라제 저해약(갈란타민 등), 글루탐산 NMDA 수용체 저해약(메만틴 등), 아밀로이드 β의 산생을 억제하기 위한 약제(γ 세크레타제 모듈레이터(GSM), γ 세크레타제 저해제(GSI), 비스테로이드성 항염증약 등), 아밀로이드 β의 응집을 억제하기 위한 약제(커큐민, 폴리황산 화합물, 클리오퀴놀 등), tau의 응집을 억제하기 위한 약제(아미노티에노피리다진, 시아닌 색소, 메틸렌 블루 등), 신경 보호약(디메본 등)을 들 수 있다.

본 발명의 조성물을 식품 조성물로서 사용하는 경우, 예를 들어 건강 식품, 기능성 식품, 특정 보건용 식품, 영양 기능 식품, 기능성 표시 식품, 영양 보조 식품, 병자용 식품 혹은 동물용 사료일 수 있다. 또한, 기능성 식품은 통상 그 작용 메커니즘에 기초하여, 프로바이오틱스, 바이오제닉스, 프리바이오틱스, 신바이오틱스의 4개로 분류되고, 본 발명에 있어서는, 프로바이오틱스, 바이오제닉스, 신바이오틱스, 프리바이오틱스의 양태를 취할 수 있다.

본 발명의 음식품은 상기와 같은 조성물로서 섭취할 수 있을 뿐 아니라, 각종 음식품으로서 섭취할 수도 있다. 음식품의 구체예로서는, 기능성 음료, 건강 음료, 젤리상 음료, 소프트 드링크, 우유 음료, 차 음료, 알코올 음료, 스프류 등의 액상 식품; 요구르트, 드링크 요구르트 등의 발효 식품, 발효 음료; 식용유, 드레싱, 마요네즈, 마가린 등의 유분을 포함하는 제품; 밥류, 면류, 팬류 등의 탄수화물 함유 식품; 햄, 소세지 등의 축산 가공 식품; 어묵, 건어물, 젓 등의 수산 가공 식품; 야채 절임 등의 야채 가공 식품; 젤리 등의 반고형상 식품; 된장 등의 발효 식품; 양과자류, 일본식 과자류, 캔디류, 껌류, 보리수, 냉과, 빙과 등의 각종 과자류; 카레, 안카케, 중화 스프 등의 레토르트 제품; 인스턴트 스프, 인스턴트 된장국 등의 인스턴트 푸드나 전자 렌지 대응 식품 등을 들 수 있다. 나아가, 분말, 에이 입자, 정제, 캡슐제, 액상, 페이스트상 또는 젤리상으로 조제된 건강 음식품도 들 수 있다. 또한, 본 발명에 있어서의 음식품의 제조는, 당해 기술 분야에 공지된 제조 기술에 의해 실시할 수 있다. 당해 음식품에 있어서는, 뇌 기능 저하의 개선 등에 유효한 1종 또는 2종 이상의 성분(예를 들어, 다른 장내 미생물, 패칼리박테리움 프라우스니치이의 장관 등에서의 증식에 유효한 성분)을 첨가해도 된다. 또한, 당해 개선 등 이외의 기능을 발휘하는 다른 성분 혹은 다른 기능성 식품과 조합함으로써, 다기능성의 음식품으로 해도 된다.

또한, 상기 「기타 장내 미생물」로서는, 특별히 제한은 없지만, 후술하는, 패칼리박테리움속에 속하는 미생물, 루미노코커스과에 속하는 속명 불명료한 미생물, 아나에로스티페스속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라속에 속하는 미생물, 루미노코커스속에 속하는 미생물, 블라우티아속에 속하는 미생물, 유박테리움속에 속하는 미생물, 푸시카테니박터속에 속하는 미생물, 박테로이데스속에 속하는 미생물, 비피도박테리움 속에 속하는 미생물을 들 수 있다. 상기 「패칼리박테리움 프라우스니치이의 장관 등에서의 증식에 유효한 성분」으로서는, 예를 들어 올리고당류, 식이 섬유류 등의 프리바이오틱스 성분, 카카오, 보리, 유글레나 그라실리스를 들 수 있다.

또한 본 발명에서 제기되는 음식품 조성물에 있어서, 보건 용도가 표시된 음식품으로서 제공·판매되는 것도 가능하다. 「표시」 행위에는, 수요자에 대하여 상기 용도를 알게 하는 모든 행위가 포함되고, 상기 용도를 직접적으로 인식할 수 있는 표현, 혹은 상기 용도를 상기·유추시킬 수 있는 표현을, 조성물 자체에 첨부한 것이어도 되고, 조성물이 함입되는 용기, 포장재 또는 첨부 문서에 첨부한 것이어도 된다. 또한 「표시」는 본 발명 조성물의 관련되는 정보로서, 광고지, 팸플릿, 팝, 카탈로그, 포스터, 서적, DVD 등의 기억 매체, 전자 게시판이나 인터넷 등의 광고 등으로, 본 발명의 조성물이 효과적인 것을 표시·광고하는 것이어도 된다.

<뇌 기능 저하의 예방 방법 등>

본 발명은 또한, 본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 당해 미생물의 배양물, 또는 그들 중 어느 것을 유효 성분으로서 포함하는 조성물(상술한 본 발명 조성물)을 대상에 투여하는 것 또는 섭취시키는 것을 특징으로 하는, 대상에 있어서의 뇌 기능의 저하를 예방, 치료 또는 개선하는 방법도 제공하는 것이다.

본 발명에 있어서 「뇌 기능」은, 판단, 지각, 계산, 기억, 이해, 학습, 사고, 언어 등의 뇌내의 정보 처리에 의해 실현하는 기능(인지 기능)을 포괄한, 뇌의 고차 기능을 의미한다. 「뇌 기능의 저하」에는, 예를 들어 경도 인지 장애(MCI), 학습 기억 능력의 저하, 판단 능력의 저하, 사고 능력의 저하, 지각 능력의 저하, 계산 능력의 저하, 언어 능력의 저하, 집중력의 저하, 또는 이들에서 기인하는 생산성 저하를 들 수 있다(단, 우울 상태, 불안 상태는 제외됨). 또한 「뇌 기능의 저하」에는, 그것을 수반하는 중추 신경 질환도 포함된다. 이러한 질환으로서는, 예를 들어 인지증을 들 수 있고, 보다 구체적으로는 알츠하이머병(알츠하이머형 인지증), 루이소체형 인지증, 파킨슨병에 있어서의 인지증 및 전두 측두형 인지증 등의 변형성 인지증; 다발 뇌경색형 인지증, 국한성 뇌경색형 인지증 및 유전성 혈관성 인지증 등의 혈관성 인지증; 약년성 인지증; 외상성 뇌 손상, 물질·의약품의 사용, HIV 감염, 프리온병 또는 헌팅턴병 등을 원인으로 하는 인지증을 들 수 있다.

본 발명에 있어서 「예방」에는, 뇌 기능 저하의 억제, 지연 및 그 재발을 억제하는 것이 포함된다. 「치료」에는, 뇌 기능 저하로부터의 완전한 회복이 포함된다. 「유지」에는, 상기 질환의 이환에 상관없이, 뇌 기능을 유지하는 것이 포함된다. 「개선」에는, 뇌 기능에 관한 증상을 완화 또는 향상시키고, 그 진행을 억제하고, 또한 그 재발을 억제하는 것이 포함된다.

본 발명에 있어서의, 뇌 기능 저하의 예방 등의 「대상」은, 인간을 포함하는 동물이다. 인간 이외의 동물로서는 특별히 제한은 없고, 각종 가축, 가금, 애완 동물, 실험용 동물 등을 대상으로 할 수 있다. 구체적으로는 돼지, 소, 말, 양, 염소, 닭, 오리, 타조, 집오리, 개, 고양이, 토끼, 햄스터, 마우스, 래트, 원숭이 등을 들 수 있지만, 이들에 제한되지 않는다. 또한, 본 발명에 관한 대상은 인지증 등의 이환자여도 되지만, 인지증 등으로 진단되어 있을 필요는 없고, 예를 들어 뇌 기능이 저하되었다고 느끼고 있는 사람, 친족에 인지증 이환자가 있는 사람, 또한 있었던 사람, 고령자, 기억 학습 능력을 개선하고 싶다고 생각하고 있는 사람을 들 수 있다. 또한, 뇌 기능에 대하여 특별한 불안 등이 없는 사람이라도, 뇌 기능 저하의 예방, 뇌 기능의 개선, 인지증 예방 등을 목적으로 하여 일상적으로 섭취할 수 있다.

또한 본 기술은 치료적 목적이어도 비치료 목적 사용이어도 된다. 「비치료적 사용」이란, 의료 행위, 즉 치료에 의한 인체에의 처치 행위를 포함하지 않는 개념이다. 예를 들어, 건강 증진, 생활 습관병 예방 등(예를 들어, 경계 영역의 예비군 등)을 들 수 있다.

본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 당해 미생물의 배양물, 또는 그들 중 어느 것을 유효 성분으로서 포함하는 조성물(상술한 본 발명의 조성물)을 투여 또는 섭취하는 경우, 그 투여량 또는 섭취량은, 대상의 연령, 체중, 상기 장애의 증상, 건강 상태, 조성물의 종류(의약품, 음식품 등), 유효 성분의 형태(예를 들어, 생균, 사균체, 균체 성분) 등에 따라서 적절히 선택된다.

본 발명의 패칼리박테리움속에 속하는 미생물(생균 또는 사균체)의 함유량 또는 사용량은 특별히 한정되지 않지만, 상기 조성물 중에 1×10의 2승 내지 1×10의 12승, 보다 바람직하게는 1×10의 3승 내지 1×10의 11승, 더욱 바람직하게는 1×10의 4승 내지 1×10의 10승이다. 또한, 단위는 CFU/g 혹은 CFU/mL, 또는 cells(개)/g 혹은 cells(개)/mL이다. CFU는 Colony forming unit를 나타낸다.

또한, 본 발명의 패칼리박테리움속에 속하는 미생물(생균 또는 사균체)의 1일당 투여량은 특별히 한정되지 않지만, 1일당 1×10의 3승 내지 1×10의 14승인 것이 바람직하고, 1×10의 4승 내지 1×10의 13승, 나아가 1×10의 5승 내지 1×10의 13승, 1×10의 6승 내지 1×10의 12승이어도 된다. 또한, 단위는 CFU/일 또는 cells(개)/일이다.

또한, 이러한 수치 범위의 상한값 및 하한값의 조합은, 예시에 지나지 않고, 그들의 조합은 적절히 변경될 수 있다. 또한, 유효 성분이 미생물의 성분(균체 성분)일 경우에는, 예를 들어 상기 균체량에 대응하는 균체 성분량으로 할 수 있다.

또한, 본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 당해 미생물의 배양물, 또는 그들 중 어느 것을 유효 성분으로서 포함하는 조성물(상술한 본 발명의 조성물)의 투여 또는 섭취량으로서는 상술한 바와 같지만, 1일당 1회 또는 복수회(예를 들어, 2회, 3회)로 나누어 투여 또는 섭취시켜도 된다. 또한, 투여 또는 섭취의 기간은, 뇌 기능 개선의 정도에 따라서 중지할 수도 있지만, 재발 예방의 관점에서, 중지하지 않고 계속해서 투여 또는 섭취시켜도 된다. 또한, 「계속」에 대해서는, 매일 계속이어도 되고, 간격을 두고 계속이어도 되지만, 효과의 점에서 매일 계속해서 패칼리박테리움 프라우스니치이 또는 그것을 유효 성분으로서 포함하는 조성물을 투여 또는 섭취하는 것이 바람직하다.

<아밀로이드 β의 축적을 억제하기 위한 조성물 등>

후술하는 실시예에 나타내는 대로, 본 발명에 의해, 뇌내에 있어서 아밀로이드 β의 축적을 억제할 수 있다. 따라서, 본 발명은 이하의 조성물 또는 방법도 제공한다. 또한, 「아밀로이드 β」 및 「축적하는 아밀로이드 β의 형태」에 대해서는 상술한 바와 같다.

본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 대상 뇌내의 아밀로이드 β 축적을 억제하기 위한 조성물.

본 발명에 관한 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 혹은 당해 미생물의 배양물, 또는 그들 중 어느 것을 유효 성분으로서 포함하는 조성물(상기 조성물)을 대상에 투여하는 것 또는 섭취시키는 것을 특징으로 하는, 대상 뇌내에 있어서의 아밀로이드 β의 축적을 억제하는 방법.

<경도 인지 장애 또는 알츠하이머병의 평가 방법>

후술하는 실시예에 있어서 나타내는 대로, 경도 인지 장애 환자 또는 알츠하이머병의 이환자와 정상인 사이에 있어서, 장내 미생물총을 비교한 결과, 숙주의 인지 기능과 관련되는 장내 미생물이 명확해졌다. 따라서, 본 발명은, 이들 장내 미생물량을 지표로 하여, 경도 인지 장애 또는 알츠하이머병의 이환을 판정하는 이하의 방법도 제공한다.

(경도 인지 장애의 평가 방법 1)

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 미생물이, 패칼리박테리움속에 속하는 미생물, 루미노코커스과에 속하는 속명 불명의 미생물, 아나에로스티페스속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라속에 속하는 미생물, 및 루미노코커스속에 속하는 미생물로 이루어지는 군에서 선택되는, 적어도 1의 미생물인, 방법.

(경도 인지 장애의 평가 방법 2)

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(알츠하이머병의 평가 방법 1)

(1) 피검자 분변 중의 미생물을 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 알츠하이머병을 이환하고 있다고 판정하는 공정을 포함하며, 또한 상기 미생물이, 블라우티아속에 속하는 미생물, 푸시카테니박터속에 속하는 미생물, 루미노코커스속에 속하는 미생물, 및 유박테리움속에 속하는 미생물로 이루어지는 군에서 선택되는, 적어도 1의 미생물인, 방법.

(알츠하이머병의 평가 방법 2)

(1) 피검자 분변 중의 미생물을 정량하는 공정,

본 발명의 평가 방법에 있어서, 그 정량 대상이 되는, 패칼리박테리움(Faecalibacterium)속에 속하는 미생물로서는, 예를 들어 패칼리박테리움 프라우스니치이, "패칼리박테리움 무레이(Faecalibacterium moorei)"를 들 수 있다.

아나에로스티페스(Anaerostipes)속에 속하는 미생물로서는, 예를 들어 아나에로스티페스 부티라티쿠스(Anaerostipes butyraticus), 아나에로스티페스 카카에(Anaerostipes caccae), 아나에로스티페스 하드루스(Anaerostipes hadrus), 아나에로스티페스 람노시모란스(Anaerostipes rhamnosivorans)를 들 수 있다.

바르네시엘라(Barnesiella)속에 속하는 미생물로서는, 예를 들어 바르네시엘라 인테스티니호미니스(Barnesiella intestinihominis), 바르네시엘라 비스세리콜라(Barnesiella viscericola)를 들 수 있다.

프레보텔라(Prevotella)속에 속하는 미생물로서는, 예를 들어 프레보텔라 알벤시스(Prevotella albensis), 프레보텔라 암니이(Prevotella amnii), 프레보텔라 아우란티아카(Prevotella aurantiaca), Prevotella baroniae(프레보텔라 바로니아에), 프레보텔라 베르겐시스(Prevotella bergensis), 프레보텔라 비비아(Prevotella bivia), 프레보텔라 브레비스( Prevotella brevis), 프레보텔라 브룬네아(Prevotella brunnea), 프레보텔라 브리안티이(Prevotella bryantii), 프레보텔라 부카에(Prevotella buccae), 프레보텔라 부칼리스(Prevotella buccalis), 프레보텔라 세레비지아에(Prevotella cerevisiae), 프레보텔라 콜로란스(Prevotella colorans), 프레보텔라 코프리(Prevotella copri), 프레보텔라 코르포리스(Prevotella corporis), 프레보텔라 덴탈리스(Prevotella dentalis), 프레보텔라 덴타시니(Prevotella dentasini), 프레보텔라 덴티콜라(Prevotella denticola), 프레보텔라 디시엔스(Prevotella disiens), 프레보텔라 에노에카(Prevotella enoeca), 프레보텔라 팔세니이(Prevotella falsenii), 프레보텔라 푸스카(Prevotella fusca), 프레보텔라 헤파리놀리티카(Prevotella heparinolytica), 프레보텔라 히스티콜라(Prevotella histicola), 프레보텔라 호미니스(Prevotella hominis), 프레보텔라 인터메디아(Prevotella intermedia), 프레보텔라 제주니(Prevotella jejuni), "프레보텔라 코레엔시스(Prevotella koreensis)", 프레보텔라 로에스케이이(Prevotella loescheii), 프레보텔라 마쿨로사(Prevotella maculosa), "프레보텔라 마르세일렌시스(Prevotella marseillensis)", 프레보텔라 마르세이이(Prevotella marshii), "칸디다투스 프레보텔라 마실리엔시스(Candidatus Prevotella massiliensis)", 프레보텔라 멜라니노게니카(Prevotella melaninogenica), 프레보텔라 미칸스(Prevotella micans), 프레보텔라 멀티포르미스(Prevotella multiformis), 프레보텔라 멀티사카리보락스(Prevotella multisaccharivorax), 프레보텔라 난세이엔시스(Prevotella nanceiensis), 프레보텔라 니그레센스(Prevotella nigrescens), 프레보텔라 오랄리스, 프레보텔라 오리스(Prevotella oralis), 프레보텔라 오리자에(Prevotella oryzae), 프레보텔라 오울로룸(Prevotella oulorum), 프레보텔라 팔렌스(Prevotella pallens), 프레보텔라 팔루디비벤스(Prevotella paludivivens), "프레보텔라 펙티노보라(Prevotella pectinovora)", 프레보텔라 포카에엔시스(Prevotella phocaeensis), 프레보텔라 플레우리티디스(Prevotella pleuritidis), 프레보텔라 라라(Prevotella rara), 프레보텔라 루미니콜라(Prevotella ruminicola), 프레보텔라 사카롤리티카(Prevotella saccharolytica), 프레보텔라 살리바에(Prevotella salivae), 프레보텔라 스코포스(Prevotella scopos), 프레보텔라 샤히이(Prevotella shahii), 프레보텔라 스테르코레아(Prevotella stercorea), 프레보텔라 티모넨시스(Prevotella timonensis), "프레보텔라 베로랄리스(Prevotella veroralis)", "프레보텔라 베스페르티나(Prevotella vespertina)", 프레보텔라 주글레오포르만스(Prevotella zoogleoformans), "프레보텔라 이후미이(Prevotella ihumii)", "프레보텔라 라스콜라이이(Prevotella lascolaii)", "프레보텔라 렉탈리스(Prevotella rectalis)"를 들 수 있다.

블라우티아(Blautia)속에 속하는 미생물로서는, 예를 들어 블라우티아 아르기(Blautia argi), 블라우티아 카에시무리스(Blautia caecimuris), 블라우티아 코코이데스(Blautia coccoides), 블라우티아 파에시콜라(Blautia faecicola), 블라우티아 파에시스(Blautia faecis), 블라우티아 글루세라세아(Blautia glucerasea), 블라우티아 한세니이(Blautia hansenii), 블라우티아 호미니스(Blautia hominis), 블라우티아 히드로게노트로피카(Blautia hydrogenotrophica), 블라우티아 루티(Blautia luti), 블라우티아 오베움(Blautia obeum), 블라우티아 프로둑타(Blautia producta), 블라우티아 쉬크니이(Blautia schinkii), 블라우티아 스테르코리스(Blautia stercoris), 블라우티아 웩슬레라에(Blautia wexlerae), "블라우티아 마라스미(Blautia marasmi)", "블라우티아 마실리엔시스(Blautia massiliensis)", "블라우티아 포카에엔시스(Blautia phocaeensis)", "블라우티아 프로벤센시스(Blautia provencensis)"를 들 수 있다.

푸시카테니박터(Fusicatenibacter)속에 속하는 미생물로서는, 예를 들어 푸시카테니박터 사카리보란스(Fusicatenibacter saccharivorans)를 들 수 있다.

루미노코커스(Ruminococcus)속에 속하는 미생물로서는, 예를 들어 루미노코커스 알부스(Ruminococcus albus), 루미노코커스 브로미이(Ruminococcus bromii), 루미노코커스 칼리두스(Ruminococcus callidus), 루미노코커스 캄파넬렌시스(Ruminococcus champanellensis), 루미노코커스 플라베파시엔스(Ruminococcus flavefaciens), 루미노코커스 가우브레아우이(Ruminococcus gauvreauii), 루미노코커스 그나부스(Ruminococcus gnavus), 루미노코커스 락타리스(Ruminococcus lactaris), 루미노코커스 토르퀘스(Ruminococcus torques), "루미노코커스 비시르쿨란스(Ruminococcus bicirculans)"를 들 수 있다.

유박테리움(Eubacterium)속에 속하는 미생물로서는, 예를 들어 유박테리움 아그레간스(Eubacterium aggregans), 유박테리움 바르케리(Eubacterium barkeri), 유박테리움 브라키(Eubacterium brachy), 유박테리움 칼란데리(Eubacterium callanderi), 유박테리움 셀룰로솔벤스(Eubacterium cellulosolvens), 유박테리움 코프로스타놀리게네스(Eubacterium coprostanoligenes), 유박테리움 인피르뭄(Eubacterium infirmum), 유박테리움 리모숨(Eubacterium limosum), 유박테리움 말토시보란스(Eubacterium maltosivorans), 유박테리움 미누툼(Eubacterium minutum), 유박테리움 멀티포르메(Eubacterium multiforme), 유박테리움 노다툼(Eubacterium nodatum), 유박테리움 옥시도레두센스(Eubacterium oxidoreducens), 유박테리움 플렉시카우다툼(Eubacterium plexicaudatum), 유박테리움 피루바티보란스(Eubacterium pyruvativorans), 유박테리움 라물루스(Eubacterium ramulus), 유박테리움 루미난티움(Eubacterium ruminantium), 유박테리움 사페눔(Eubacterium saphenum), 유박테리움 시라에움(Eubacterium siraeum), 유박테리움 술시(Eubacterium sulci), 유박테리움 테누에(Eubacterium tenue), 유박테리움 토르투오숨(Eubacterium tortuosum), 유박테리움 우니포르메(Eubacterium uniforme), 유박테리움 벤트리오숨(Eubacterium ventriosum), 유박테리움 크실라노필룸(Eubacterium xylanophilum), 유박테리움 유리이(Eubacterium yurii)를 들 수 있다.

파라박테로이데스(Parabacteroides)속에 속하는 미생물로서는, 예를 들어 파라박테로이데스 아시디파시엔스(Parabacteroides acidifaciens), "파라박테로이데스 부체스두로넨시스(Parabacteroides bouchesdurhonensis)", 파라박테로이데스 카르타에(Parabacteroides chartae), 파라박테로이데스 킨킬라에(Parabacteroides chinchillae), 파라박테로이데스 콘기이(Parabacteroides chongii), 파라박테로이데스 디스타소니스(Parabacteroides distasonis), 파라박테로이데스 파에시스(Parabacteroides faecis), 파라박테로이데스 골드스테이니이(Parabacteroides goldsteinii), 파라박테로이데스 고르도니이(Parabacteroides gordonii), 파라박테로이데스 존소니이(Parabacteroides johnsonii), "파라박테로이데스 마실리엔시스(Parabacteroides massiliensis)", 파라박테로이데스 메르다에(Parabacteroides merdae), "파라박테로이데스 파카엔시스(Parabacteroides pacaensis)", "파라박테로이데스 프로벤센시스(Parabacteroides provencensis)", "파라박테로이데스 티모넨시스(Parabacteroides timonensis)"를 들 수 있다.

또한, " "로 둘러싸인 이름은, 「유효하게 게시되지 않음(not validly published)」인 것을 나타낸다.

루미노코커스(Ruminococcaceae)과에 속하는 속명 불명의 미생물로서는, 예를 들어 서열 번호: 423 내지 497에 기재된 뉴클레오티드 서열 중 적어도 1의 서열과 80％ 이상의 상동성을 갖는 DNA를 함유하는 미생물을 들 수 있다.

CAG-41속에 속하는 미생물로서는, 예를 들어 서열 번호: 498 내지 504에 기재된 뉴클레오티드 서열 중 적어도 1의 서열과 80％ 이상의 상동성을 갖는 DNA를 함유하는 미생물을 들 수 있다.

본 발명에 관한 「상동성」에 대해서는, 상술한 바와 같지만, 뉴클레오티드 서열의 상동성도, BLAST 등의 얼라인먼트 프로그램을 이용하여 결정할 수 있다. 예를 들어, 뉴클레오티드 서열의 상동성이란, blastn을 사용하여 산출되는 뉴클레오티드 서열간의 상동성을 들 수 있고, 보다 구체적으로는 blastn을 디폴트의 파라미터를 사용하여(즉, 초기 설정의 파라미터를 사용하여) 산출되는 뉴클레오티드 서열간의 상동성을 들 수 있다.

또한, 뉴클레오티드 서열에 관한 여기에서의 「상동성」은, 전술한 바와 같이, 예를 들어 80％ 이상(보다 구체적으로는 81％ 이상, 82％ 이상, 83％ 이상, 84％ 이상)이지만, 바람직하게는 85％ 이상(예를 들어, 86％ 이상, 87％ 이상, 88％ 이상, 89％ 이상), 보다 바람직하게는 90％ 이상(예를 들어, 91％ 이상, 92％ 이상, 93％ 이상, 94％ 이상), 더욱 바람직하게는 95％ 이상(예를 들어, 96％ 이상, 97％ 이상, 98％ 이상, 99％ 이상), 특히 바람직하게는 100％이다.

본 발명의 각 평가 방법에 있어서, 정량 대상이 되는 미생물은 적어도 1종류이면 되지만, 바람직하게는 2종류 이상(예를 들어, 3종류 이상, 4종류 이상), 보다 바람직하게는 5종류 이상(예를 들어, 6종류 이상, 7종류 이상, 8종류 이상, 9종류 이상), 더욱 바람직하게는 10종류 이상이다.

본 발명의 평가 방법에 있어서의 「피검자」에 대해서는 특별히 제한은 없고, 상술한 「뇌 기능 저하의 예방 등의 대상」과 마찬가지이다. 또한, 그 비교 대상이 되는 「정상인」에 대해서도 특별히 제한은 없지만, 상기 피검자와, 연령, 성별, 인종 또는 국적 및 인지증 이외의 기왕력 중 적어도 1의 특징이 마찬가지인 사람이 바람직하다.

「분변 중의 미생물의 정량」은 당해 미생물의 양(수) 그 자체가 아니어도 되고, 예를 들어 당해 미생물의 양(수)을 반영하는 당해 미생물 특유의 물질의 양을 측정함으로써 행할 수 있다. 이러한 물질로서는, 상기 미생물 특이적인 올리고뉴클레오티드(예를 들어, 16SrRNA 유전자, 및 그 전사물), 상기 미생물 특유의 구성 물질(당해 미생물을 구성하는, 펩티드, 핵산, 당, 지질, 및 그들의 복합체 등), 당해 미생물에 의한 생성물(예를 들어, 당해 미생물의 분비 산물, 당해 미생물에 의한 대사 산물)을 들 수 있다.

물질이 올리고뉴클레오티드일 경우에는, 예를 들어 PCR(RT-PCR, 리얼타임 PCR, 정량 PCR), DNA 마이크로어레이 해석법, 노던 블로팅, 차세대 시퀀싱법(합성 시퀀싱법(sequencing-by-synthesis, 예를 들어 일루미나사제 Solexa 게놈 애널라이저 또는 Hiseq(등록 상표) 2000에 의한 시퀀싱), 파이로 시퀀싱법(예를 들어, 로쉐·다이아그노스텍스(454)사제의 시퀀서 GSLX 또는 FLX에 의한 시퀀싱(소위 454 시퀀싱)), 리가아제 반응 시퀀싱법(예를 들어, 라이프 테크놀로지사제의 SoliD(등록 상표) 또는 5500xl에 의한 시퀀싱), T-RFLP법, 비즈 어레이법, 동일계내(in situ) 하이브리다이제이션, 도트 블롯, RNase 프로텍션(protection) 어세이법, 질량 분석법, 게놈 PCR법, 서던 블로팅을 사용하여 정량할 수 있다.

기타 물질에 대해서는, 예를 들어 ELISA법, 이뮤노블로팅, 항체 어레이 해석법, 면역 조직 화학적 염색법, 플로 사이토메트리, 이메이징 사이토메트리, 방사선 면역 검정, 면역 침강법 등의 항체를 사용하여 검출하는 방법(면역학적 방법)을 사용하여, 정량할 수 있다.

또한, 이와 같이 정량하여 얻어지는 값은, 절대량뿐만 아니라, 상대값이어도 된다. 상대값으로서는, 예를 들어 검출에 사용하는 측정 방법 또는 측정 장치에 기초하는 양비(소위, 임의 단위(AU)로 표시되는 수치)를 들 수 있다. 또한, 상대값으로서는, 예를 들어 후술하는 실시예에 나타내는 대로, 장내 미생물총 전체에 있어서의 그 미생물의 비율을 나타내는 값(상대 존재량, 점유율)이어도 된다. 또한, 참조 장내 미생물의 양을 기준으로 하여 산출한 값을 사용해도 된다. 본 발명에 관한 「참조 장내 미생물」은, 분변 시료에 있어서 안정적으로 존재하고 있고, 또한 다른 생체 시료간에 있어서, 그 양의 차가 작은 미생물이면 된다.

또한, 후술하는 실시예에 있어서 나타내는 대로, 경도 인지 장애 환자와 정상인 사이에 있어서, 특정한 DNA량을 비교한 결과, 숙주의 인지 기능과 관련되는 DNA가 명확해졌다. 따라서, 본 발명은, 이들 DNA의 양을 지표로 하여, 경도 인지 장애의 상태를 판정하는 이하의 방법도 제공한다.

(경도 인지 장애의 평가 방법 3)

경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 DNA를 정량하는 공정,

(경도 인지 장애의 평가 방법 4)

경도 인지 장애의 평가 방법이며,

(1) 피검자 분변 중의 DNA를 정량하는 공정,

(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다 높은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한

상기 DNA가, 서열 번호: 297에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA인, 방법.

본 발명의 각 평가 방법에 있어서, 정량 대상이 되는 「서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA」에 대해서는, 상술한 바와 같다. 또한, 당해 DNA 외에도, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 있어서, 1개 또는 복수의 아미노산이 치환, 결실, 부가 및/또는 삽입된 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA, 또는 서열 번호: N에 기재된 뉴클레오티드 서열을 포함하는 DNA와 엄격한 조건 하에서 하이브리다이징하는 DNA도, 정량 대상으로 될 수 있고, 이들 DNA에 대해서도 상술한 바와 같다.

본 발명의 각 평가 방법에 있어서, 정량 대상이 되는 DNA는, 적어도 1종류 있으면 되지만, 상기 「경도 인지 장애의 평가 방법 3」에 있어서는, 바람직하게는 2종류 이상(예를 들어, 3종류 이상, 4종류 이상), 보다 바람직하게는 5종류 이상(예를 들어, 6종류 이상, 7종류 이상, 8종류 이상, 9종류 이상)이다.

「경도 인지 장애의 평가 방법 3 및 4」에 있어서도 「피검자」는 상술한 바와 같다. 「분변 중의 DNA의 정량」은, 당해 DNA(게놈 DNA)의 양(수) 그 자체가 아니어도 되고, 예를 들어 당해 DNA의 양(수)을 반영하는 물질의 양을 측정함으로써 행할 수 있다. 이러한 물질로서는, 전사 산물(mRNA), cDNA, 번역 산물(펩티드)을 들 수 있다. 또한, 이들 물질의 정량은, 상술한 바와 같이, 당업자라면 물질의 종류에 맞게, 공지된 정량 방법을 적절히 채용하여 행할 수 있다.

또한, 이와 같이 정량하여 얻어지는 값은 절대량뿐만 아니라, 상대값이어도 된다. 상대값으로서는, 예를 들어 검출에 사용하는 측정 방법 또는 측정 장치에 기초하는 양비(소위, 임의 단위(AU)로 표시되는 수치)를 들 수 있다. 또한, 상대값으로서는, 예를 들어 분변 중의 전체 DNA에 있어서의 정량 대상으로 하는 DNA의 비율을 나타내는 값(상대 존재량, 점유율)이어도 된다. 또한, 참조량을 기준으로 하여 산출한 값을 사용해도 된다. 본 발명에 관한 「참조량」은, 분변 시료에 있어서 안정적으로 존재하고 있고, 또한 다른 생체 시료간에 있어서, 그 양의 차가 작은 DNA이면 된다.

본 발명의 평가 방법(상술한 「알츠하이머병의 평가 방법 1 및 2」, 그리고 「경도 인지 장애의 평가 방법 1 및 2 내지 4」)에 있어서는, 정량하여 얻어지는 값과, 정상인에 있어서의 그것(대응값)을 비교한다. 이러한 비교는, 당업자라면 상기 검출 방법에 맞은 통계학적 해석 방법을 적절히 선택하여 행할 수 있다. 통계학적 해석 방법으로서는, 예를 들어, t 검정, 윌콕슨의 부호 순위 검정, 분산 분석(ANOVA), 크라스칼·월리스 검정, 맨·휘트니의 U 검정(윌콕슨의 순위합 검정), 오즈비, 해저드비, 피셔의 정확 검정, 수신자 동작 특성 해석(ROC 해석), 분류목과 결정목 해석(CART 해석)을 들 수 있다. 또한, 비교 시에는, 정규화된 또는 표준화 또한 정규화된 데이터를 사용할 수도 있다.

경도 인지 장애 또는 알츠하이머병 이환의 판정은, 통상, 의사(의사의 지시를 받은 사람도 포함함)에 의해 행해지지만, 상술한 미생물량 또는 DNA량 등에 관한 데이터는, 의사에 의한 치료의 타이밍 등의 판단도 포함한 진단에 도움이 되는 것이다. 따라서, 본 발명의 방법은, 의사에 의한 진단을 위해 상술한 미생물량 또는 DNA량 등에 관한 데이터를 수집하는 방법, 당해 데이터를 의사에 제시하는 방법, 상술한 미생물량 또는 DNA량 등과 상기 대응값을 비교하여 분석하는 방법, 환자의 임상 증상 및/또는 기타 검사 결과를 고려한 후에 의사에 의한 진단을 보조하기 위한 방법으로도 표현할 수 있다.

실시예

이하, 실시예에 기초하여 본 발명을 보다 구체적으로 설명하지만, 본 발명이 이하의 실시예에 한정되는 것은 아니다.

(실시예 1) 역학 시험

숙주의 뇌 기능에 관여하는 장내 미생물(장내 세균)을 선발하기 위해서, 인지 기능 등의 뇌 기능이 정상적인 사람(정상인), 경도 인지 장애(MCI) 환자 및 알츠하이머병(AD)을 이환하고 있는 사람, 각각으로부터 분변을 채취하고, 각 분변 중의 장내 미생물의 구성을, 그들 미생물의 16SrRNA 서열을 시퀀싱함으로써 해석하였다.

구체적으로는 2015년에 군마현 구사쓰마치(일본)에서 행해진 건강 진단에 참가한 사람들로부터, 정상인 21명, MCI 환자 15명으로, 본 역학 시험의 피험자(모두 65세 이상)로서 참가하게 하였다. 또한, 구사쓰마치의 양로원에 사는 사람, 구사쓰마치 공적 개호 서비스의 이용자, 및 같은 해의 건강 진단에 참가한 사람 중에서 65세 이상의 AD 이환자 7명에게 피험자로서 참가하게 하였다.

또한, 피험자로부터는,

(1) 분변 채취 시 2주일 전부터 항생 물질을 사용한 사람,

(2) 과거 반년, 소화관의 외과 수술을 받은 사람,

(3) 염증성 장질환, 염증성 장증후군, 소화관에 있어서의 종양 및 위 절제 방법 등의, 소화관 장애에 관한 기왕력을 갖는 사람,

(4) 당뇨병의 기왕력을 갖는 사람, 및

(5) AD 이외 중 어느 유의미한 신경학적 및 정신 질환의 기왕력을 갖는 사람을 제외하였다. 또한, 모든 피험자에는, 도쿄도 건강 장수 의료 연구 센터의 윤리 위원회에 의해 승인된 연구 프로토콜의 상세한 설명을 한 후, 서면에 의한 인폼드·콘센트를 얻었다.

피험자의 평가는,

(1) 정신 상태 단기간 검사(MMSE), 몬트리올 인지 평가 검사 일본어판(MoCA-J) 및 임상 인지 평가법(CDR)으로, 인지 기능을 평가하고,

(2) 노연식 활동 능력 지표(Tokyo Metropolitan Institute of Gerontology Index of Competence; TMIG-IC)로, 기본적인 일상 생활 동작(ADL)을 평가하고,

(3) 병력 및 현재의 투약에 관한, 의사의 문진을 행하고,

(4) 혈액 검사 및 혈압 등의 건강 진단 데이터를 사용하여,

행하였다.

피험자는 정상인의 그룹, MCI 그룹 및 AD 그룹의 3개의 그룹으로 나누었다. 정상인과 MCI 환자란, Petersen의 기준에 준하여 진단하였다. 구체적으로는 (1) 기억 수소(愁訴)가 없고,

(2) MoCA-J≥26,

(3) MMSE≥24,

(4) CDR 스코어가 0이고,

(5) ADL의 스코어가 5이고,

(6) 신경 질환 및 정신 질환을 이환하고 있지 않은

경우, 피험자는 건강하다고 진단하였다.

한편, (1) 기억 수소가 있고,

(2) MoCA-J≤25,

(3) MMSE≥24,

(4) CDR 스코어가 0.5이고,

(5) ADL의 스코어가 5이고,

(6) 신경 질환 및 정신 질환을 이환하고 있지 않은

경우, 피험자를 MCI라고 진단하였다.

AD의 이환은, 의학적인 인터뷰와 앙케이트를 사용하여, 정신 장해의 진단과 통계 매뉴얼(DSM)-IV 기준에 기초하여, 의사에 의해 판단되었다.

분변은 채변 키트(가부시키가이샤 테크노스루가·라보제)를 사용하여 채취하고, 동결 보존하였다. 그리고, 각 분변 중의 장내 미생물의 구성을, 차세대 시퀀서로 해석하기 위해서, 거기에 제공하기 위한 라이브러리를 조제하였다. 구체적으로는 우선, 채취한 변으로부터 DNA를 추출하였다. 얻어진 DNA를 주형으로 하여, 미생물의 계통 해석용으로 16SrRNA 영역(16SrRNA의 V3-V4 영역)을 PCR로 증폭시켰다. PCR 증폭 후에는, 라이브러리 제작용 DNA 프래그먼트 분획·회수 키트(Thermo Fisher Scientific사제, 제품명: E-Gel(등록 상표) SizeSelect Gels)를 사용하여, 상기 목적 영역을 포함하는 증폭 산물을 추출한 후, index 부가를 행하고, DNA 정제 시약 키트(Beckman Coulter사제, 제품명: Agencourt ampure XP beads)를 사용하여 정제하였다. 이어서, 이와 같이 하여 조제한 라이브러리 용액에 대해서, 농도 측정 및 Bioanalyzer(Agilent사제)를 사용한 전기 영동에 의해, 퀄러티 컨트롤(QC)을 실시하였다. 그리고, 각 샘플의 라이브러리액을 등mol 혼합하고, 차세대 시퀀서(Miseq)로 시퀀싱을 행하였다.

얻어진 시퀀싱 결과에 기초하여, 바이오인포매틱스 해석을 행하고, 장내 미생물의 존재 비율 등을 산출하였다. 구체적으로는 미생물 군집 해석 프로그램 「QIIME2」 및 GTDB 데이터베이스를 사용하여 계통 조성을 산출하고, R에 의해 유의미하게 차가 있는 계통을 추출하였다. 얻어진 결과를 도 1 및 2에 나타낸다.

상기 시험의 결과, 129의 속이 얻어졌다. 그리고, 도 1 및 2에 나타내는 대로, 정상인 vs MCI, 정상인 vs AD 중 어느 군간 비교에 있어서 유의차가 보이는 11의 미생물을 선발할 수 있었다.

그 중에서도, 패칼리박테리움(Feacalibacterium)속에 속하는 미생물, 루미노코커스(Ruminococcaceae)과에 속하는 속명 불명의 미생물, 아나에로스티페스(Anaerostipes)속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라(Barnesiella)속에 속하는 미생물, 및 루미노코커스(Ruminococcus)속에 속하는 미생물의, 장내 미생물총에 있어서의 상대 존재량은, 정상인에 비해, MCI 환자는 낮았다(도 1에 있어서, 횡축 0의 라인보다 왼쪽에 위치하고, 또한 P=0.05의 라인보다 위에 위치하는 미생물). 한편, 프레보텔라(Prevotella)속에 속하는 미생물의 상대 존재량은, 정상인에 비해, MCI 환자가 높았다(도 1에 있어서, 횡축 0의 라인보다 오른쪽에 위치하고, 또한 P=0.05의 라인보다 위에 위치하는 미생물).

또한, 루미노코커스과에 속하는 속명 불명의 미생물이란, 상기 바이오 인포매틱스 해석에 있어서, 루미노코커스과에 계통 어사인먼트되었지만, 속명 불명의 unclassified의 미생물을 의미하고, 구체적으로는 16SrRNA의 V3-V4 영역을 코딩하는, 서열 번호: 423 내지 497 중 어느 것에 기재된 DNA 서열을 갖는 미생물이다. 또한, CAG-41속에 속하는 미생물은, 16SrRNA 영역의 V3-V4 영역을 코딩하는, 서열 번호: 498 내지 504 중 어느 것에 기재된 DNA 서열을 갖는 미생물이다.

또한, 블라우티아(Blautia)속에 속하는 미생물, 푸시카테니박터(Fusicatenibacter)속에 속하는 미생물, 루미노코커스(Ruminococcus)속에 속하는 미생물, 및 유박테리움(Eubacterium)속에 속하는 미생물의 장내 미생물총에 있어서의 상대 존재량은, 정상인에 비해, AD 이환자쪽이 낮았다(도 2에 있어서, 횡축 0의 라인보다 왼쪽에 위치하고, 또한 P=0.05의 라인보다 위에 위치하는 미생물). 한편, 파라박테로이데스(Parabateroides)속에 속하는 미생물의 상대 존재량은, 정상인에 비해, AD 이환자는 높았다(도 2에 있어서, 횡축 0의 라인보다 오른쪽, 또한 P=0.05의 라인보다 위의 미생물).

따라서, 이상의 장내 미생물이, 숙주의 뇌 기능(인지 기능 등)에 관여하고 있는 것이 시사되었다.

이어서, 정상인 vs MCI 환자, 정상인 vs AD 이환자 중 어느 군간 비교에 있어서 유의차가 보인 미생물의 상대 존재량(relative abundance)과 인지 기능 테스트 MoCA-J의 결과의 상관을 분석하기 위해, 정상인 및 MCI 환자를 대상으로 하여, 스피어만의 상관 분석을 행하였다. 얻어진 결과를 표 1에 나타낸다.

표 1에 나타내는 대로, 상기 분석의 결과, 몇 가지 속에서 유의미한 상관이 보여졌다. 특히, 패칼리박테리움 프라우스니치이(Fp)는 유의미한 상관이 확인되었을 뿐 아니라, 상대 존재량 자체가 높고, 도 1에 나타내는 대로, 정상인과 MCI 환자에 있어서 상대 존재량에 있어서의 유의차가 확인되었기 때문에, 이하의 실시예에 있어서는, 패칼리박테리움속에 속하는 미생물에 착안하여 해석을 진행시켰다.

(실시예 2) 단리 시험

전술한 바와 같이, 실시예 1에 있어서, 뇌 기능과 관련되는 장내 미생물을 속 레벨로 찾아내었다. 그래서, 정상인 및 MCI 환자의 분변을, 혐기 하에 배양하고, 상기 속에 속하는 균주를 단리하였다.

구체적으로는 우선, 정상인 및 MCI 환자의 분변을 각각, 혐기 챔버 내(N₂=90％, CO₂=5％, H₂=5％)에서 10^-5 내지 10^-7로 단계 희석하였다. 얻어진 각 분변 희석액을, YCFA 한천 배지, EG 한천 배지, 또는 이들 배지에 항생 물질을 첨가한 배지에 도포하였다. 37℃에서 1 내지 2일간 배양한 후, 생육한 콜로니 내에서 약 7000콜로니를 픽업하고, 필요수의 계대를 반복함으로써, 콜로니를 싱글화하였다. 싱글화한 단리주는 20％ 글리세롤 용액에 -80℃에서 보존하였다.

또한, 단리주를 보존하기 직전에, 균체의 일부를 글래스 비즈를 넣은 5％ 트리톤 용액에 현탁시키고, 균질화함으로써 단리주의 DNA를 추출하였다. 그리고, 16SrRNA 유전자를 증폭하기 위한 유니버설 프라이머 세트(27F 프라이머 및 1492R 프라이머)를 사용한 PCR을 행함으로써, 추출한 DNA로부터 16SrRNA 유전자를 증폭시켰다. 이어서, 27F 프라이머를 사용하여 PCR 증가 부산물의 시퀀스를 실시하였다. 얻어진 서열 데이터에 대하여, 3종류의 데이터베이스(NCBI, Eztaxon, Ltp)에서 BLAST 해석을 실시하여, 단리주의 균종을 특정하였다.

구체적으로는 12의 패칼리박테리움 프라우스니치이(Fp)주(Fp1, Fp4, Fp14, Fp28, Fp40, Fp45, Fp77, Fp137, Fp360, Fp944, Fp1043, Fp1160)를 단리·특정하였다. 또한, Fp944만이 MCI 환자에서 유래하고, 나머지 11주는 정상인 유래이다.

(실시예 3) 유효성 동물 시험 1

뇌 기능과 관련되는 장내 미생물 중, 실시예 2에서 단리·특정한 상기 12의 Fp주에 관한 것이고, 아밀로이드 β 뇌실내 투여 마우스에 각 균주를 단기간(11일간) 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, Y 미로 시험 및 수동 회피 시험을 사용하여 평가하였다.

구체적으로는 혐기 챔버 내에서, Fp주를 YCFA 배지에 시작하고, 37℃에서 24시간 배양하였다. 그 후, 배양액을 LYBHI 배지로 계대하고(식균 용량: 5％), 또한 24시간 또는 48시간 배양하였다. 그 배양액을 원심 농축시켜, 피험 물질로서 사용하였다. 또한, 피험 물질은, 그 20배 희석의 탁도(McFARLAND SCALE)가 0.6(6.6×10의 8승cells/mouse에 상당)가 되도록 조정하였다. 피험 물질은 마우스에의 투여까지 -80℃에서 보존하였다.

마우스는 Slc:ddY 웅성 마우스(5주령)를 사용하였다. Fp주 등의 피험 물질은 1일 1회, 11일간 반복 경구 투여하였다. 그 투여 3일째에 아밀로이드 β를 뇌실내에 단회 투여하였다. 또한, 컨트롤로서, 이하의 군을 설정하였다.

대조군 1: 주사용수를 뇌실내 투여하고, 매체(생리 식염액)를 경구 투여하는 허위 수술군,

대조군 2: 아밀로이드 β를 뇌실내 투여하고, 매체(생리 식염액)를 경구 투여하는 매체 대조군,

대조군 3: 아밀로이드 β를 뇌실내 투여하고, 매체(배양 배지)를 경구 투여하는 매체 대조군,

대조군 4: 아밀로이드 β를 뇌실내 투여하고, 아리셉트(도네페질염산염)를 0.5mg/kg 체중 경구 투여하는 대조군

또한, 각 피험 물질군 및 상기 각 대조군을 1군 9마리로 설정하였다.

투여 9일째의 피험 물질 투여 1시간 후에 Y 미로 시험을 행하고, 투여 10 내지 11일째의 피험 물질 투여 1시간 후에 수동 회피 시험을 행하였다.

Y 미로 시험에는, 1개의 암의 길이가 39.5cm, 바닥의 폭이 4.5cm, 벽의 높이가 12cm이며, 3암이 각각 120도로 분기되어 있는 플라스틱제의 Y자형 미로를 사용하였다. 상기 마우스를 Y자형 미로 중 어느 암에 두고, 7분간 미로 내를 자유롭게 탐색시켰다. 마우스가 측정 시간 내에 진입한 암의 순번을 기록하고, 암에 진입한 횟수를 세고, 총 엔트리수로 하였다. 이어서, 이 중에서 3회 연속해서 다른 암에 진입한 횟수를 세고, 이 수를 자발적 교체 행동수로 하였다. 또한 이하의 식을 사용하여 자발적 교체 행동율을 산출하였다. 측정은, 관찰자가 군 정보를 모르는 상황(블라인드)에서 행하였다.

자발적 교체 행동율(％)=[자발적 교체 행동수/(총 엔트리수-2)]×100

얻어진 결과를 도 3에 나타낸다.

수동 회피 시험에는, 중앙의 기요틴 도어로 칸막이된 명실(W: 100×D: 100×H: 300mm)과 바닥의 그리드로부터 전기 자극을 부여하는 암실(W: 240×D: 245×H: 300mm)을 구비한 step through형 수동적 회피 반응 장치를 사용하였다. 동물을 명실에 넣어 10초 후에 기요틴 도어를 살짝 열고, 동물이 암실에 들어갈 때까지의 시간(반응 잠복 시간)을 측정하였다. 획득 시행(투여 10일)은, 동물이 암실에 들어감과 동시에 기요틴 도어를 닫아 전기 자극(0.2mA, 2sec, 스크램블 방식)을 부여하고, 전기 자극 부하 시의 동물의 울음소리의 유무를 확인하였다. 반응 잠복 시간의 측정은 최장 300초까지로 하였다. 유지 시행(투여 11일)은, 동물이 암실에 들어가거나, 명실에서 300초 경과하면 종료로 하였다. 얻어진 결과를 도 4에 나타낸다.

상기 Y 미로 시험의 결과, 도 3에 나타내는 대로, Fp14, Fp28, Fp77 및 Fp360에 있어서, 배지 투여군과 비교하여, 자발적 교체 행동율의 통계학상 유의미한 개선이 확인되었다. 또한, 상기 수동 회피 시험의 결과, 도 4에 나타내는 대로, Fp360에 있어서, 배지 투여군과 비교하여, 반응 잠복 시간의 통계학상 유의미한 증가가 확인되었다. 또한, Fp360에 이어서, Fp1043 및 Fp14에 있어서도, 반응 잠복 시간의 증가 가능성이 확인되었다. 따라서, 이들 Fp주, 특히 Y 미로 시험 및 수동 회피 시험의 양쪽에 있어서 유효성이 시사된 Fp14 및 Fp360은, 학습·기억 장애 등의 뇌 기능 저하에 대하여 개선 효과를 발휘할 가능성이 확인되었다.

(실시예 4) 유효성 동물 시험 2

실시예 3에 있어서, 뇌 기능 저하에 대한 개선 효과가 시사된 Fp14 및 Fp360에 관하여, 그들의 배양 상청 및 사균체에 대해서도, 학습 기억 장애의 개선의 정도를 평가하였다. 배양 상청 및 사균체는 이하의 방법으로 제조하였다.

<배양 상청의 조제 방법>

혐기 챔버 내에서, Fp주의 스톡 균액을 YCFA 배지에 배양하였다(37℃, 24시간). 또한, 식균 용량 5％가 되도록 배양액을 LYBHI 배지로 계대 배양하였다(37℃, 24시간). 배양액을 원심 분리(800×g, 실온, 10분간) 및 필터(0.22㎛ 직경) 처리하여, 배양 상청을 얻었다. 배양 상청은 동물 투여까지 -80℃에서 보존하였다

<사균체 용액의 조제 방법>

혐기 챔버 내에서, Fp주의 스톡 균액을 YCFA 배지에 배양하였다(37℃, 24시간). 또한, 식균 용량 5％가 되도록 배양액을 LYBHI 배지로 계대 배양하였다(37℃, 24시간). 배양액을 원심 분리(800×g, 실온, 10분간)하여 상청을 제거한 후, 생리 식염액을 사용한 원심 세정을 2회 실시하였다. 생균 검체의 조정과 마찬가지의 탁도가 되도록, 생리 식염액을 사용하여 얻어진 균체를 현탁시키고, 가열 처리(70℃, 30분간)함으로써 사균체 용액을 얻었다. 사균체 용액은 동물 투여까지 -80℃에서 보존하였다.

그리고, 이와 같이 하여 조제한 배양 상청 및 사균체 용액을, 피험 물질로서, 실시예 3에 기재된 방법 마찬가지로, 아밀로이드 β 뇌실내 투여 마우스에 단기간(11일간) 투여하고, 당해 마우스에 있어서의 학습 기억 장애의 개선의 정도를, Y 미로 시험 및 수동 회피 시험을 사용하여 평가하였다(각 피험 물질군 및 상기 각 대조군을 1군 12마리로 설정하였다). 얻어진 결과를, 도 5 및 6에 나타낸다.

Y 미로 시험의 결과, 도 5에 나타내는 대로, 실시예 3(도 3)에 있어서도 나타낸 대로, Fp14 및 Fp360의 양쪽에 관하여, 생균 투여에 의한 개선 효과 및 개선 경향이 확인되었다. 또한, Fp360의 사균체를 투여함으로써, 배지 투여군과 비교하여, 자발적 교체 행동율의 개선 경향이 확인되었다.

또한, 수동 회피 시험의 결과, 도 6에 나타내는 대로, 실시예 3(도 4)에 있어서도 나타낸 대로, Fp360에 관하여, 생균 투여에 의한 개선 효과가 확인되었다. 한편, Fp14에 관하여, 사균체로 함으로써 생리 식염액 투여군과 비교하여, 통계학상 유의미하게 반응 잠복 시간이 증가하는 것이 밝혀졌다.

(실시예 5) wholegenome 해석 1

실시예 3 및 4에 있어서, 뇌 기능 저하에 대한 유효성이, Y 미로 시험 및 수동 회피 시험의 양쪽에 있어서 시사된 Fp주(Fp14 및 Fp360)와, 어느 시험에 있어서 확인되지 않은 Fp주(상기 2주 이외의 10주)에 있어서, 도 7에 나타내는 파이프라인에 따라서, 전체 게놈을 비교하여, 전자에 특징적인 유전자를 추출하는 것을 시도하였다.

구체적으로는 우선, 혐기 챔버 내에서, Fp주를 YCFA 배지에 시작하고, 37℃에 24시간 배양하였다. 그 후, 800×g, 10분, 4℃에서 원심 후, 상청을 폐기하고, 혐기 PBS에 의해 세정하였다. 그 후, 원심 및 PBS 세정을 2회 반복하여, 균체 펠릿을 동결 보존하였다.

균체 펠릿으로부터, 게놈 DNA 정제용 음이온 교환 칼럼과 그 전용 버퍼(제품명: NucleoBond(등록 상표) AXG 20, NucleoBond Buffer Set III, 모두 마하라이·나겔사제)를 사용하여 게놈 DNA를 조제하였다. 또한, 당해 게놈 DNA를, DNA 단편화 튜브(제품명: g-TUBE, 고바리스사제)에 의해, 물리적으로 단편화하였다.

이들 단편화 DNA를, 차세대 시퀀스(PacBio 시퀀스)에 제공하기 위해서, 우선, 단편화한 DNA의 양쪽 말단을 평활화한 후, SMRTbell 어댑터를 연결하고, 시퀀스의 주형이 되는 시퀀스 라이브러리(SMRTbell Template)를 제작하였다. 제작한 SMRTbell Template는 펄스 필드 전기 영동에 의해 사이즈 분포를 확인하고, 자동DNA 단편 겔 추출 장치(제품명: BluePippin, Sage Science사제) 또는 DNA 정제 시약(제품명: AMPure XP, 베크만·콜터사제)을 사용하여 사이즈 셀렉션을 행하였다. 이어서, 시퀀스 라이브러리 양쪽 말단의 SMRTbell 어댑터에 상보적인 서열을 갖는 시퀀스 프라이머와, DNA 폴리메라아제를 결합시켜, 시퀀스 템플릿으로 하였다. 이 템플릿을 자기 비즈와 결합시켜, SMRT(등록 상표) Cell 위에 어플라이하고, 웰(Zero-mode waveguides; ZMW) 내에 시퀀스 템플릿을 고정하고, 1분자 리얼타임 DNA 시퀀서(제품명: PacBio RS II, Pacific Biosciences사제)에 의해 시퀀스 반응을 행하였다.

그리고, 시퀀스로 얻어진 리드를 시퀀서 부속의 소프트웨어 SMRT Analysis를 사용하여 다시(de novo) 어셈블을 행하였다. 어셈블에 의해 얻어진 콘티그에 대해서, Circlator 파이프란을 사용하여 이하의 처리를 행하였다.

우선, 전체 길이가 다른 콘티그에 포함되는 것에 대해서는 제거하였다. 계속해서, 양쪽 말단이 오버랩되는 것에 대해서는 환상화를 행한 다음 dnaA 유전자 서열을 사용하여 게놈 서열 개시 위치의 수정을 행하였다. 그 후, Quiver를 사용하여 재폴리싱을 행하였다. 재폴리싱에 있어서는, 환상화 처리 등을 행한 후의 콘티그(콘센서스 서열)에 대하여 서브 리드의 매핑을 행하고, 그 결과를 바탕으로 콘센서스 서열의 수정을 행하였다. 또한, 게놈의 완전성 및 콘타미네이션은 CheckM(v1.0.08)에 의해 판정하였다.

그리고, 얻어진 환상 전체 게놈의 서열 중의 유전자(코딩 영역(CDS))의 예측 및 게놈의 애노테이션을, Prokka(v1.12)를 사용하여 행하였다.

이어서, 상기 예측된 유전자 정보에 기초하여, 2개의 다른 오르토로그 탐색 툴(Roary(v3.12.0), Orthofinder(v2.3.11))에 의해, 오르토로그를 동정하였다. 또한, Roary 및 Orthofinder는 이하의 조건에서 행하였다.

(1) Roary

주로 BLASTP의 동일성 70％ 이상의 상동성으로 동일한 오르토로그에 클러스터링(Bioinformatics, 31권, 22호, 2015년 11월 15일 발행, 3691 내지 3693페이지 참조).

(2) Orthofinder

orthofinder 독자의 역치로 오르토로그에 클러스터링. 보다 구체적으로는 all vs all의 blastp의 비트 스코어를 사용하여 orthofinder 독자의 스코어(normalized score)를 산출한 후, 어떤 쿼리에 있어서 RBNH(Reciprocal Best length-Normalized hit=normalized score가 쌍방향으로 best hit임)이거나, 혹은 normalized score가 있는 쿼리의 가장 낮은 RBNH 이상인 경우, 동일한 오르토로그에 클러스터링(Genome Biol. 2015년 8월 6일; 16(1): 157 참조).

또한, 상기 예측된 유전자를, Diamond(v0.9.10.111, 동일성의 역치>40, 스코어>70 및 범위(coverage)>80)를 사용하여, KEGG 유전자 및 KEGG 오르토로그(KO)에의 애노테이션을 행하였다(참조한 KO데이터는, 2017년 5월 시점의 것임). 이어서, KO를, Roary 또는 Orthofinder에 의해 동정된 오르토로그에 할당하였다.

또한, 상기 예측된 유전자 정보에 기초하여, 단백질의 도메인 예측을, InterProScan(v5.40-77.0) 및 TMHMM(v2.0)을 사용하여 행하였다. 또한, TMHMM에 있어서는, 서열의 전체가 inside 또는 outside로 분류되었을 경우에는, 그것은 세포막 단백질을 포함하지 않고, 세포내 단백질 또는 세포외 단백질이라고 예측하였다. 한편, 서열의 전체가, 적어도 하나의 transmembrane helix로 분류되었을 경우에는, 막 관통 단백질이라고 예측하였다.

그리고, 이와 같이 하여 각 Fp주에 특유한 서열(유전자)의 오르토로그 및 각 Fp주에 특유한 KO를 포함하는 오르토로그를 동정하였다(이하, 이들을 총칭하여 「유니크한 오르토로그」라고 칭함).

추출된 Fp14 및 Fp360의 양쪽 Fp주에 특유한 서열의 오르토로그를, 표 2에 나타낸다.

또한, 「ICBIDGAJ」 및 「BLCPAMOF」는, Fp14 및 Fp360의 전체 게놈 해석에 있어서, Prokka에 의해 예측된 각 유전자에 부여된 ID를 나타낸다. 또한, 그들 유전자의 서열을, 서열 번호: 1 내지 27 및 29 내지 57에 각각 나타낸다. 또한, 표 2에 있어서, 가로 배열의 유전자끼리(예를 들어, ICBIDGAJ_00324(서열 번호: 9)와 BLCPAMOF_01513(서열 번호: 30))는 오르토로그의 관계에 있다.

또한, Fp14 및 Fp360을 특징짓는 유니크한 KO1684에 대응하는 유전자로서 ICBIDGAJ_00537과 BLCPAMOF_00623(서열 번호: 28과 서열 번호: 422)이 추출되었다.

이상의 결과, Fp14 및 Fp360을 특징짓는 유니크한 28의 오르토로그가, 추출되었다. 그 중에서도, Roary 및 Orthofinder를 사용한 양쪽 해석에 있어서 공통되어 추출된 3오르토로그는, 도 8에 나타내는 대로, 게놈 상에 연속해서 존재하고 있었다. 또한, 도메인 해석의 결과, 이들 3오르토로그는, TMHMM에 의해 막 관통형 도메인이나 균체외 도메인을 코딩하고 있다고 예측되었다.

(실시예 6) wholegenome 해석 2

이어서, 실시예 5에 기재된 방법과 마찬가지로 하여, Fp14와, Fp360을 포함하는 기타 11주에 있어서, 전체 게놈을 비교하여, Fp14에만 특징적인 유전자 및 KO를 추출하였다.

그 결과, Roary 및 Orthofinder의 양쪽 해석에 있어서 공통되고, 서열 번호: 58 내지 207에 기재된 DNA 서열에 대응하는, Fp14에 특유한 150의 오르토로그를 선발할 수 있었다. 그 중, Fp14만을 특징짓는 유니크한 146의 유전자(서열 번호: 58 내지 203으로서 나타냄) 중에서도, 연속되는 유전자에 착안한 결과, 미지의 균체외 단백질이나 선모 관련 단백질을 각각 코딩하는 유전자가 연속해서 배열되어 있는 영역이 확인되었다(도 9 참조).

또한, Fp14만을 특징짓는 유니크한 KO로서는, 서열 번호; 60, 110, 140 및 204 내지 207에 기재된 뉴클레오티드 서열에 대응하는 8개의 KO가 추출되었다. 그들 중, KO1226(ICBIDGAJ_00755(서열 번호: 205)), KO2818 및 KO2819(ICBIDGAJ_00754(서열 번호: 204)), 그리고 KO3486(ICBIDGAJ_00753(서열 번호: 206))은, 트레할로오스에 관련되는 KO이며, 도 10에 나타내는 대로, Fp14만을 특징짓는 유니크한 유전자(ICBIDGAJ_00757 및 00756)에 인접해 있었다. 또한, KO2819 및 KO1226은, 균체외의 트레할로오스를 도입하여 트레할로오스-6P 등을 산생하는 대사 경로(세포외 트레할로오스로부터, 트레할로오스-6P를 거친, D-글루코오스-6P를 생성하는 경로)에 관여하는 KO이다.

(실시예 7) wholegenome 해석 3

이어서, 실시예 5에 기재된 방법과 마찬가지로 하여, Fp360과, Fp14를 포함하는 기타 11주에 있어서, 전체 게놈을 비교하여, Fp360에만 특징적인 유전자 및 KO를 추출하였다.

그 결과, Roary 및 Orthofinder의 양쪽 해석에 있어서 공통되고, 서열 번호: 208 내지 421에 기재된 DNA 서열에 대응하는, Fp360에 특유한 214의 오르토로그를 선발할 수 있었다. 중, Fp360만을 특징짓는 유니크한 197의 유전자가 추출되었다(서열 번호: 208 내지 404로서 나타냄). 또한, Fp360만을 특징짓는 유니크한 KO로서, 서열 번호; 212, 228, 229, 238, 247, 249, 257, 274, 276, 279, 290, 296, 309, 335, 336, 337, 342, 371, 377 및 405 내지 421에 기재된 뉴클레오티드 서열에 각각 대응하는 36의 KO가 추출되었다. 그들에 있어서, 연속으로 배열되는 KO로서, 세포 분열에 관련되는 KO 등이 확인되었다.

(실시예 8) 메타게놈 해석

실시예 1에 있어서의 역학 시험에서 조제된, 장내 메타게놈 샘플 중에 있어서, 실시예 5 내지 7에서 추출된, 뇌 기능 저하에 대한 유효성이 확인된 Fp주(Fp14 및/또는 Fp360)에 유니크한 오르토로그의 장내 미생물총에 있어서의 상대 존재량을 검출하였다. 그리고, 그들 상대 존재량을 군간 비교하였다(정상인과 MCI 환자의 비교, 정상인과 AD 이환자의 비교).

구체적으로는 우선, 전체 메타게놈 쇼트건 시퀀싱을 행하였다. 시퀀싱 라이브러리는 TrueSeq Nano DNA 라이브러리 조제 키트(Illumina사제)를 사용하여 조제하였다. 라이브러리의 품질은 Agilent 2100 바이오 애널라이저를 사용하여 확인하였다. 실시예 1에서 얻은 분변 시료를 대상으로 하는, 전체 메타게놈 쇼트건 시퀀싱은 HiSeq2500 플랫폼(Illumina사제)에서 행하였다. 모든 시료에 관하여, 150bp의 리드의 길이로써, 15.0Gb의 target date 사이즈에 대한 페어 엔드 시퀀스를 행하였다.

그 결과, 합계 6,421,909,374(평균 149,346,730)의 페어 엔드의 리드는, 합계로 963,286,406,100(평균 22,402,009,444)의 염기쌍을 커버하고 있었다.

이어서, 품질 관리를 위해, 문자 「N」(식별되지 않은 기본 페어)을 포함하는 생(生)의 리드는 파기하였다. 박테리오파지 phiX DNA 서열을 포함하는 리드는, Bowtie 2(버전 2.2.9)를 사용하고, 그 옵션(fast-local)으로, 리드와 매핑함으로써 식별하여 파기하였다. 이어서, Cutadapt(버전 1.9.1)를 사용하여, 어댑터 서열 및 프라이머 서열의 리드를 트리밍하였다. 연속해서 17 이하의 품질값을 포함하는 리드는, Cutadapt 프로그램으로 3' 말단을 제거하였다. 이어서, 50염기쌍 미만의 길이의 리드를 파기하고, 또한 평균 품질값이 25 이하인 리드를 파기하였다. 이어서, 리드를 인간 게놈에 대하여 매핑하였다(gi24 numbers: from 568336000 to 568336023, http://www.ncbi.nlm.nih.gov/nuccore/568336023/, GRCh38) using Bowtie2(버전 2.2.9)). 그리고, 매핑된 것은 인간 게놈으로부터 파생된 것이라고 생각하고, 폐기하였다. 마지막으로, 페어가 되지 않은 리드를 파기하였다.

그 결과, 934,484,415,900(평균 21,732,195,719)의 염기쌍을 수반하는, 합계 6,229,896,106(평균 144,881,305)의 페어 엔드 리드가, 고품질의 리드로서 얻어지고, 하기 장내 미생물총에 있어서의 상대 존재량의 해석에 제공하였다.

유니크한 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, Kallisto(v0.46.2)에 의해 TPM(transcripts per million)값을 산출하고, 그들에 기초하여 평가하였다. 그리고, 상기 각 유니크한 오르토로그의 상대 존재량을, R(3.6.3)을 사용하여 군간(정상인 및 MCI간, 정상인 및 AD간) 비교하였다.

그 결과, 도 8과 같이, 예를 들어 Fp14 및 Fp360을 특징짓는 유니크한 유전자이며, 막 관통형 단백질과 예측된 ICBIDGAJ_02236 및 BLCPAMOF_02134의 서열이 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

도 10과 같이, Fp14에 유니크하고, 균체외 단백질과 예측된 ICBIDGAJ_00756이 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다. 또한, 당해 오르토로그의 상대 존재량은, AD 이환자와 비교하여 정상인에서 유의미하게 높은 경향이 있었다.

도 10과 같이, Fp14에 유니크한 KO가 해당하고(할당(assign)되고), ICBIDGAJ_00753, 00754 및 00755가 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

Fp360에 유니크하고, BLCPAMOF_02713이 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

Fp360에 유니크하고, 세포 분열 관련의 KO가 해당하고, 막 관통형 단백질로 추정된 BLCPAMOF_00796이 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

Fp360에 유니크하고, 세포 분열 관련의 KO가 해당하고, 세포내 단백질과 예측된 BLCPAMOF_01742가 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

Fp360에 유니크하고, BLCPAMOF_02824가 속하는 오르토로그의 장내 미생물총에 있어서의 상대 존재량은, Orthofinder만에 의한 해석에 있어서, MCI 환자와 비교하여 정상인에서 유의미하게 높았다.

(실시예 5) 장기 동물 유효성 시험

상기 Fp14의 배양액을, AD 모델 마우스에 장기간(13개월간) 투여하고, 뇌 조직 중의 아밀로이드 β량을, 면역 조직화학적 염색 분석으로 측정하였다.

구체적으로는 혐기 챔버 내에서, Fp14를 YCFA 배지에 시작하고, 37℃에 24시간 배양하였다. 그 후, 배양액을 LYBHI 배지로 계대하고(식균 용량: 5％), 또한 24시간 또는 48시간 배양하였다. 그 배양액을 원심 농축시켜, 피험 물질로서 사용하였다. 피험 물질은 마우스에의 투여까지 -80℃에서 보존하였다.

AD 모델 마우스로서, APP-tg 마우스(8주령, 수컷, SPF 그레이드)를 사용하였다. 당해 마우스에 주 4회, 13개월간, 상기 피험 물질을 경구 투여하였다. 1회의 경구 투여에서는, 357μl(20배 희석의 탁도(McFARLAND SCALE)가 0.6인 균량, 6.6×10의 8승cells/mouse 상당) 투여하였다. 마우스 사육 종료 후, 마우스 뇌를 채재(採材)하였다. 채재된 뇌는 정중 시상(矢狀) 절단하고, 반뇌를 -80℃에서 동결 보존하였다. PFA 고정액(0.1％ 글루타르알데히드+4％ 파라포름알데히드) 중에서 침지 고정하였다.

그리고, PFA 고정한 반뇌를, 수크로오스 치환에 제공한 후에 포매하고, 크라이오스탯(Leica사제, CM1860)을 사용한 동결 절삭에 의해, 40㎛의 얇게 썬 절편을 조제하였다. 부유 절편을 PBS로 2회 세정한 후, 시트르산 완충액 중에서 121℃, 15분의 오토클레이브에 넣어, 항원 활력화를 행하였다. 시트르산 완충액이 실온으로 되돌아간 것을 확인하고, PBS로 1회 세정 후, 0.1％ TritonX-100(w/v) 첨가 PBS(이하T-PBS)에 30분간 반응시킴으로써 막 투과 처리를 행하였다. Blocking One Histo(나카라이테스크사제)를 사용하여 블로킹 처리를 하고, 비오틴 표지 항체(Anti-β-Amyloid(17-24), Mouse-Mono(4G8), Biotin(토미 디지탈 바이올로지 가부시키가이샤, 형식 번호: 800704))와 4℃에서 철야 반응시켰다. 형광 표지 스트렙트아비딘을 반응시킴으로써, 표적 단백질을 표지하고, 공초점 레이저 현미경(Zeiss사제, LSM700)을 사용하여 형광 화상을 취득하였다. 그리고, 얻어진 화상 데이터에 기초하여, 피질, 해마, 및 그들에 있어서, 축적 아밀로이드 β량을 반영하는 노인반 점유율을 분석하였다.

도 11에 나타내는 대로, Fp14의 투여에 의해, AD 모델 마우스의 해마에 있어서의 아밀로이드 β의 축적량은 저감 경향이 확인되었다. AD의 발증, 진행은, 뇌내에서 생성한 아밀로이드 β가 섬유화, 응집되고, 축적되는 것에 의한 것으로 생각되고 있다. 그 때문에, 적어도 Fp14는 상기 실시예 3(유효성 동물 시험)의 결과와 함께, AD의 예방, 치료, 개선에 유효할 가능성이 나타내졌다.

이상 설명한 바와 같이, 본 발명에 따르면, 장내에 있어서의 특정한 미생물량을 지표로 하여, 인지증, 또는 경도 인지 장애 혹은 그 전단계의 진단을 행하는 것이 가능해진다. 특히, 본 발명에 있어서는, 경도 인지 장애 및 알츠하이머병 각각에 관련되는 장내 미생물을 밝히고 있기 때문에, 이들 인지 기능의 저하를 판별하여 평가하는 것도 가능해진다.

또한 본 발명에 따르면, 특정한 DNA 서열을 갖는 패칼리박테리움 프라우스니치이주를 투여함으로써, 대상의 뇌 기능의 저하, 특히 인지 기능의 저하를 예방 또는 치료하는 것이 가능해진다. 또한, 뇌 기능, 특히 인지 기능을 유지 또는 개선하는 것도 가능해진다.

따라서, 본 발명은, 뇌 기능의 저하, 특히 인지증에 관한, 진단 방법, 예방 방법 및 치료 방법의 개발 등에 있어서 유용하다.

수탁 번호

(1) 식별의 표시: Fp_0014

(2) 수탁 번호: NITE BP-03169

(3) 수탁일: 2020년 3월 6일

(4) 기탁 기관: 독립행정법인 제품평가기술기반기구 특허미생물기탁센터

(1) 식별의 표시: Fp_0360

(2) 수탁 번호: NITE BP-03196

(3) 수탁일: 2020년 4월 7일

독립행정법인 제품평가기술기반기구 특허미생물기탁센터

NITEBP-03169

20200306

독립행정법인 제품평가기술기반기구 특허미생물기탁센터

NITEBP-03196

20200407

SEQUENCE LISTING <110> Otsuka Pharmaceutical Co., Ltd. TOKYO INSTITUTE OF TECHNOLOGY <120> COMPOSITION FOR PREVENTING OR TREATING DETERIORATION IN BRAIN FUNCTION OR MAINTAINING OR IMPROVING BRAIN FUNCTION <130> IBPF21-550WO <150> JP2020-201008 <151> 2020-12-03 <160> 504 <170> PatentIn version 3.5 <210> 1 <211> 183 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(183) <223> ICBIDGAJ _01576 <400> 1 atgacagtag cacggaaacg agcacttgca aacgcagtgg catcggcccg gatggagggg 60 ctggagatct cagagcagga aaagagagac tgcctgcgct atctggatgg aaaaatcgat 120 actgcaaccc ttgtaagaga agcattgaaa cgtcagaaaa agcaggagct gtcccggagg 180 tga 183 <210> 2 <211> 279 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(279) <223> >ICBIDGAJ_01078 <400> 2 gtgcctagtc tgttccggct gttcggttat gtgattttct tctggagcaa tgaaggtgca 60 ccgctggaac cggttcatgt ccatgttgca aagggtgttc cgaatgccag tgcaacaaag 120 atctggatta cggaagcggg aggctgtatc gtggccaaca ataactcgaa gattcctgcc 180 agaacgttga gcgcaattgt agatgttctg gaaagccgtt caagctacat tgtggcacag 240 tggaacgatg tgtttggtga atcgaagttc tactgctga 279 <210> 3 <211> 399 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(399) <223> ICBIDGAJ_00623 <400> 3 atgcgaaaac gatacaacac gccgcaccgc aaccgggtag tcaagacacg catgaccgag 60 gaagaatacg ccgagtttgc ggaaaggctt tctgcctgca acatgagcca agccgagttt 120 atccggcaag ccataaccgg ggcagccata cgccctatca taaccgtttc ccccgtcaac 180 gacgagctgc ttgccgctgt cgggaagctg accgccgaat acggcaggat cggcggcaac 240 ttaaaccaga tagcccggac gctgaacgag tggcacagcc cctacccgca gcttgccggg 300 gaggtacggg cggcggtttc cgaccttgct gccctaaagt ttgaagtctt gcagaaagtg 360 ggtgacgctg ttggcaacat tcaaacatat cagctctaa 399 <210> 4 <211> 195 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(195) <223> ICBIDGAJ_02224 <400> 4 gtgaaagaag ttccgatttg gcaaaagagt aatctgacct tggaggaagc ggcggcttac 60 tctgggatcg gtatcaataa actgcggtcg atgaccgata gcgatgaatg caagttcgtc 120 ctttggaacg gaaccaaacg gcttatcaaa cgccgtaagc tggacgaata tctggacaag 180 gcattctcga tctga 195 <210> 5 <211> 639 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(639) <223> ICBIDGAJ_01075 <400> 5 atgcgaaaaa gaatctgtgc tcttgcgtta acttccgtat ttttatgcgc ttgtctgtct 60 ggttgtagcg aatcttcaca gcctaatgct ccagcttcta attcaaacaa ttcttattct 120 agtagtacct cagataataa ttctagttca tcttctgaat caaaatctga tgaaaccaat 180 gacaattcca attcatctac tacaactaaa aaagatgcaa tttcaacacg tcttgataaa 240 atatctcatg aacgcgctca aacaggaaaa ggtgttcatg ttttgggaag ggatggtgtt 300 tggcgctggg aatatgctta tacctaccag ctgcatgtat atatcactgt aaaaaatacg 360 ggtgattacc gtgccaaagt taatagttct aactttagcg catactggga ttcctctaga 420 ttagctaact ccggtacagt atttgatgcc acctataatg aaaacggtct tgctcctggc 480 gctcagacta caataaagct aatttatgat atctccgaat atcagtataa tagttggaat 540 acccccggtc ataatattac ccttggtgtg cagtatggta atggaacatt ggcttatgtt 600 tattcaacag ataccggttc tgtaaaagca taccattaa 639 <210> 6 <211> 300 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(300) <223> ICBIDGAJ_01076 <400> 6 atgacggccg accgcatcaa ggccctgaga gaatcgcgag ggtggacgca ggcagagctt 60 gcacgcagga tgaatatgac gagaaacggt atcaattcat gggagcaggg gctttcgatg 120 ccgtcgccgc agagcctggt ggatttggct aggctgtttt ctgtctcgac agattacctg 180 ctgggtgtag aaaagcataa tacagtaaac gtgactggtt tggatgaaaa ggatgtcgca 240 ctgattgcgc agctcgcaga acgcctgcgg agtgcggcga aaaacaatga aaacacatga 300 <210> 7 <211> 267 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(267) <223> ICBIDGAJ_01077 <400> 7 atgctttatc cttttatgac cttgaatgat gggacggaaa tcgtttattc ctcgccaatt 60 cagaatggca atcaggagca ggtaaaggta cagattgaaa cacctgtaga aaacggcttt 120 aagtcggcga cctgtattct gccggggtat ttgtggacca ataatggcta ttctgaaatg 180 gagatggcga gcctgaaaga gctggtcaaa tcaacggcac atcttctgat ccgcttctcg 240 catgaggggg ggatcgaaag tgcctag 267 <210> 8 <211> 1233 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1233) <223> ICBIDGAJ_02223 <400> 8 atgcaaagac gtaaagataa caaaggccgt gttctgaagg atggcgaggt ctaccgcaag 60 agtgacgggc tgtatatgta ccgttggact gcgaaaaacg gaaaacgcca taccatctat 120 gatgcaacct tggaggggct gcgcgaaaag gaagagaaga tacagcgcga cttggcagag 180 ggcatccgta tgccggagtg caatctgacc ctgaacgacc tctttgaact gtggcgtaag 240 aacaaggtgg gcttgaaaga gcataccttc gccaattacg tttatatgta caatcggttc 300 gtccgggatg agatcggcag gatgaagctc aaggacattc gcaagtcgga tatccgcagc 360 tactacaatg gcatcgtccg caatggcaag atggcgttga acacgctgga aaccatccag 420 aatgttcttc atcaggtctt tgcggtggcg gtggacgatg agtacatccg tgtgaatccc 480 acggatggtg tcctgacggc cattaaagcc gcccaccagt acgaaacgcc aaaacgccac 540 gctctgaccc tgccccagca gcaggcattc ctgagtttca tcaagaaaac gccaaaattc 600 cagcactggc tcccgatgtt cactttcatg ttgggtacgg gatgccgaat ctcggaaacg 660 gtgggtctgt gctggagtga catcgacttt gagagtgggt ttattaccat tcagcacaat 720 ctggtgtacc atgaccacga agtcggtggc tgttacttca ccatgtccac gcccaaaact 780 gccgcaggca aacgggcaat tcccatattg cccgaagttc ggaaagcgtt ggagcaggaa 840 cgagccaatc agcaggaact ggaactggtg tgtgagtacg aaatcgacgg catctcggac 900 tttgtgtttc taaaccgctt cggtcagccg cagaatccgc agaccgtcaa ccgtgctatc 960 aagcgcatca gcgttgccta caatgaagcc gaactggaaa aggccgaaaa ggcaaagcgg 1020 gaaccgcagt tattgccacc cttctcctgc cataatctcc ggcacacgtt ctgcacccgg 1080 ttgtgcgaaa acgaaaccaa cctgaaaatc attcaggaca tcatgggaca ccgggacatc 1140 aaaacgacca tggagattta cgcagaagcc accaaggaag ccaagaccca ttcctttgaa 1200 aaattgaacg gtaaactggg catttccatc tga 1233 <210> 9 <211> 1386 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1386) <223> ICBIDGAJ_00324 <400> 9 atgggaaaat attttggaac cgatggcttc cgtggcgagg ccggtgtgaa cctgaccgcc 60 gaccacgcct acaaggtggg ccgttttctg ggctggtatt ataatgcact gcgggagcgc 120 agcggcaaca atgagcctgc ccgcatcgtc attggcaagg acacccgccg cagctcgtac 180 atgttcgagt acagcctggt ggcgggcctg accgcttccg gcgcggatgc ctacctgctc 240 cacgtcacca ccacccccag cgtggcctac attgcccgcg tagatgattt tgactgcggc 300 attatgatct ctgccagcca taacccgttc tacgacaacg gcatcaagct gatcgactgc 360 tacggcgaaa agatgcctga ggagaccctg ctgctggtgg aggactacat cgacggcaag 420 ctccatgtct ttgatcagga ctggccggag ctgccctttg cccaccggga gcatatcggc 480 tgtaccgtgg actatgtggc aggccgcaac cgctacatgg gctacctgat cagcctgggc 540 atctactcct tcaagggcat caaggtgggt ctggactgcg ccaacggtgc cagttggaac 600 attgccaaga gcgtgttcga tgcgctgggc gcagacacct atgtcatcaa caaccagccc 660 aacggcctga acatcaatct gaacgcaggc tccacccaca tcgagggcct gcagaagttt 720 gtggtggaaa agggtctgga tgtgggcttt gcctatgacg gcgatgcaga ccgctgcctc 780 tgcgtggacg aaaagggcaa tgtgatcacc ggcgaccaca tcctgtacat ctatggctgc 840 tacatgaagg agcgcggcaa actgctgacc aacaccgttg tcaccacggt catgtccaac 900 tttggtctgt acaaggcctt tgacgagcag ggcatcggct acgccaagac tgccgtgggt 960 gacaagtatg tctacgagta tatggccaag aacggctgcc gcatcggcgg tgagcagagc 1020 ggccacatca tcttctccaa gtacgccagc accggtgacg gcatcctgac cagcctgaag 1080 atgatggagg tcatgctggc caagaagaag cctctgagtg cgttggccgc cccgctgaag 1140 atctacccgc aggtgctgga aaatgtccgt gtgaccgata agaaggccgc gcaggacgat 1200 gccgctgtgc aggccgctgt caaggcggtg gccgaggcac tgggcgatac cggccgcatc 1260 cttgtccggg agtccggcac cgagccggta gtccgtgtga tggtggaggc ccctgaccac 1320 gacacctgcc agaagtacgt ttctcaggtg gtggatgtca tcaaggcaca gggctacagc 1380 gtctga 1386 <210> 10 <211> 1272 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1272) <223> ICBIDGAJ_01852 <400> 10 atgaacatca tatataaaat ctgtagtaaa cttagggaaa aaggttgtat gggtttttta 60 aagacagtaa atacacattt ggtgggagcg ataaataaaa aattatatag agcgtttcaa 120 taccaacgca taaatgaaaa gttgctggtg tttgaaagcg aaggtgattt aacggataat 180 tcgtatgcat tgtatgatta tatgaacaaa aaaggttatt tgaagaagta tcagacagtc 240 tggttggtaa atgatatttc gagtgcacta ggttatgcaa aacgcgaagg gggatttcct 300 aatacaactt tcgttaagaa atttccagaa cacattgatt tgaggtggag caaatcttta 360 gcaacctgca agtatttttt ttatgaccat agtaatgtaa tgcatgactt aaagaaaagg 420 aaacaacaaa ctgttgttta cctgacacat ggatttgctg gttataaagc tgggaaggga 480 ggaacagaaa aagaagaatt tacttatcca gattatgtga tggtaacatg taaattatct 540 gccgaattat atccttcctt tgcgaatttt ggaaaagcga aattcctgac aatgggtatg 600 cccagattgg attatttcgg agacgataat agtacgatta gaaataaaat agagagcgaa 660 tacagattat cacgatacaa gaaggttttt ttgtggatgc cgaccttccg tgaatctaac 720 cacaaggaaa tctcggaaga atatttgagg acagagactc atttgccaat tatagaaaca 780 gaaattattt tggacaagtt taatttgttt ttacaggaac gaagtctttt aatggttctg 840 aaaatccatc cattgcaaaa aaatcttcca gtattccaaa aaaaatactc caatattatc 900 tttttgagag atgagcaact tcacgagata aatgtacagc tgtatcaatt tattgcacta 960 actgatgcac ttatcacaga ttattcatca atttctgcag attatatgtt gctaaatcgg 1020 ccgatgattt ttactttgga tgactatgaa gaatataagg agtcaagagg agagttttta 1080 ccggggaacg caattgatta ctggactggt gcgcatgtat ataatctaaa ggaattttgt 1140 tcggctattg aagaaattga aaaaggcaaa gatccatata agaaggaaag agaaaaactg 1200 atttctatat tttatgaagg aacaaagcgt gattcagcta agaaaatctt aaatttcttt 1260 aggatgatat aa 1272 <210> 11 <211> 10047 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(10047) <223> ICBIDGAJ_01754 <400> 11 atggcatgga cagcagaaca gatggcccaa aagcgggcca aacttcagaa aaaaaccaat 60 gccgctgctg gtggggcaga acccctcagt cagcgcaaga gcgctgacag ccgcaacccg 120 ttagcccttg gcagtacggg aaactctgtg tcggacaata gcaatccatg gacggcggaa 180 aaaatggccg aaaaacgtgc ggcactgcaa acccagaaac agcagacggg caccgacctg 240 tactccacgg cgctggagga ttaccggaca aggaacaacc tgggctttgc ggatgccatg 300 gacagccgga gcgacgagct gaaccggcag aaggtgacag tgagcccggc ggggaatact 360 ctgggaacgt ggtacggaca gcaggcccag aagctgaaga acagctatgc ggagtacagc 420 cagccggagg cctttgacca ggccaaccag tggtttgacc agcctcggaa tcaggagctt 480 gtgaacaagc tgctggaaaa gaagagcaat tataccagct atgccgagac cggcaccagc 540 agaaacgggg ccagcgccgg ggatggtagc atcgacccct tccgcaccac gggaatcaag 600 gggaaggtgg gcaacaccta cagcacggcg gacctgaaaa agctggggta cacggacacg 660 gagatccggc aggccaggga gtatctggac accatggaag aaatcccgga gtggaagcag 720 ctggcccggc ggacggcaaa cactgtgggc ggcgttgcgg acaccgtggc cgctgccccg 780 ctgatgggtg cggagtacct ggtgcaggcc ggaaagaaca tccggcagag cagcgagaac 840 cggaaagcac tggaagcaga gcttgcccgg aacccccgcg agaagaacct gtatgaccag 900 ctgatggaaa ctgacatgga ctaccagccc aagtacagca ccggcgacct gttgcagcag 960 ggatttaccc ggcaggagat cgaggacatg cgcagccgca ttgccggaac ggaagcaaag 1020 ggtggcatcg acacggagaa gagcgtgggc taccagctgt acaaccgggg ccagcagctg 1080 acgggcgcgg cccagagcgg cctgaccgat gtgcagcgga ccgtgcaggg cgtggcgacc 1140 agcgcggcag agaaccttgc cgtggctgcc atcaatccgg cggcggtgct gccggtgctg 1200 agtgcccagg gcgctgcgga tgccatgggc cagagcgcgg ccaagggcga aagcgcaggc 1260 aaggcgctgg tgggcggcgt ggcaaagttt ggcgcaggat gggccatcaa cagcgtgggt 1320 gcggctgatc tggcaagaac catgggcgcg gactacgcca gaaattccgt ggcgggagct 1380 gtggcagaca agatccgggc gctggctggg gattcggcct ttgcggcggc acatccggcg 1440 gttgccaacg ccatttccgg cggcattgac aacgccgtgc aggcctttgt ggagacctac 1500 gccgacaagg ccattgatgc ggccctggga gacagcgaag ctgcccagac catgtttacc 1560 acggacacgc tggttcaggc gctggaagcg gggctgaccg gcggcgcgtc cggtgcactg 1620 ggcggcgctg tgggcacagg gctttccagg atgaacgcgg gagattccag cctgcggggc 1680 aacgtggagc ggtatgccgc tcaggacgaa tacgagcagg cgctgaagga acaccagcgc 1740 cgggaggagc tggcgcggga accggaaccc ctcagtcagc gcgtgagcgc tgacagcccc 1800 cctaatagtg gggcccttgg catgtcggtg gagtctgatg ggactgaaaa aggctctgct 1860 gacctgaaag cggcgggccc tgcggctgag ggcaacagtg cagaaactgc tgccatatcg 1920 gacaacttgg ctgtgcagac gtttgcagaa gcggcgaccg gtgacagcct gacaggcaag 1980 accatcaggc tgttcacccc ggaggccgga aacgaggcaa accgcgcggc ttttgaggaa 2040 gcctatgggg tggagttgcc gagcacggct gcggctaccc ggcggatgct gcgggaagtg 2100 gcggcacagc gcagccagca gaatgctgtt gagaacgctg gggaaagtgt ggaaagcccc 2160 acggaaacag cggcggacgg cgcagaaccc ttcagtcatc gcataagcgc tgacagtcgc 2220 aacccgttag cccttggcag tgcggaaaac actggtctga ctgcgcagaa tggagctgac 2280 cggcaggctg tgatgcagtc ggtccctgtg gaagaaagca cccttgacgg gatggacagc 2340 agcaacagcc cgatgcggga gacctacggc atggaagcac cgaggacgga aggccagaag 2400 caggcccgga cggagcaggt gctgcggagc tggaaggtgg gcgaaaaggc agcgcaggag 2460 atcagccgga aacagccgga aggcgtggac agtgaccgct atgcggcggc agcatccact 2520 ttgtaccggc tgggccagat ggaggacgtg aagaactttg accaggcgct gaagctggcg 2580 ggcaccggca gcggcatggc ggccaacgtg aactatgtgc tgggcaacct caagggccgg 2640 aacgcgctgg agatcgccta cacctacggc agggatgcgg cagagacccg gtgggccaag 2700 agccagctgg gcggcactct gacggaacag agcctgacgg gcaggggtga gaccatctac 2760 aagggaacca cgcggagtga gaacgacgca ggcagccagg tgatcgagct gaacgcggcg 2820 gcaaccggca ccacggcggt tctgaaaaac gtgctgcaga acggtgcggg acaggcagac 2880 agccgggtgc gggcctatgt ggacacggag acggcacgga tcttctttgg agacagcgca 2940 caggatacgt tcggcacggt gctgcacgag gactaccact ggtacaacgc actggacagc 3000 gagggagcca agaccttgca ggaccatgcc ctgctgtatc tggccaggag cagcggcttt 3060 gagaccgtgg acgagatgat ccgggagaag atgaccgact atgcccagca gaatctgacc 3120 tatgaggaag ctgccgagga gctggtgggc gatgcctggc ggggcatctt ctccaatgaa 3180 tccgatttca agcgctgggt agagttccag cgcgggcagg ccgagaagaa cagcggcagg 3240 gccggaacca tccgcaccgt gatgaaccgg gtgaaggaga tgctggacgg cattgtgagc 3300 cgggccaagg aagtgctgac ccttgacccc gacaaccggg ctgccatgaa ggcccagcgc 3360 ctggccgaga acgagcgcag aattttgcag gacgaatact ttgcccacgc tgaaaaagcg 3420 atggacaacc tgcgcagtgc aaaagaaaac gccgctgccc ccaagacaga gagcgcggcg 3480 gaaggacgca atattcgttt ttcgatccag aaggatgccg acggagagag ctacatcaaa 3540 attgatgaag atatcctgaa cggtgtaccc cgtgaagaat ggaaaactgt ggtgaaacag 3600 gcaatcaagg agcggtatcc gaacggcttt gagcggaacg gctggacaat tttgaaccat 3660 aaagatggaa gaagtgagtt tgtccgttct aaatctacaa tggcgcttca gagaacgaac 3720 gaagaaacgt atgcagataa aatgcggatg gctgcaaatc tggatgaaat tattaaaacc 3780 gcagatgaag tctacagaga acctgcaaac cacaagaatg cggaagcatt caaccgtgga 3840 aaaatcaaaa ttgtggttgg gcagaatgcc tatgaagctg atgttctgac tgccttcaaa 3900 gcaaatgacc gggagatttt ctatgatatt gtagatataa aatctacaaa taataaaacc 3960 tccatgcgta cccacgtaga atccaaagat tcaaggagta gtctgcaagg aggttttacg 4020 gaaccctccg gcaaagccca catggaatcc gaagattcgg ggagcagagg gtcggagggt 4080 tctatttatc aggaaagcgc tgacacggta ctcaaaaccg aggagggcgg tgaacgcccg 4140 agctttcctg ctaaaaacag tatagcacaa gaaaatgccg aaagcaaggg aaacagcgaa 4200 cctgtgaaga aatcagtgcg gttccagctg agtgacggct ctgctggaaa cgtggatgaa 4260 ttggcggcac ttcaaaaaga aagtcgggaa ctggaacacc agcaaaacgc cctgaaaaca 4320 gagcgaacaa actggctgaa cagcgccgag gtaaaggaga ttgaagggaa gagaaaatct 4380 ctgggtttgt tctctgccga ggcaaaggag tttaaggcca gtgaagaata ccaggcgtac 4440 cttgcaaagc ggaaggactt taaccagcgt ggtgcagagc ttgaaaaccg aatcggtgaa 4500 gtgaataatg cactgcggga agcccatgcc aagctggaaa cccagagaaa tgaacagaag 4560 cagaaacagc aggctgtcta tgatgccaaa gcaaaggaag caggcggtgc ggcgaagtat 4620 cgccgtcagc tggccgtgga gcagtttggc acgacgagtg aatttgaacg ggccggatac 4680 atcctgccgg atgggcagat gctggatttt gcccggaatg ataagacccg tgacaccgac 4740 caccgggaaa ttatgagtgt gttcggcccg gcggaagtat cggaagggac ggacgcactg 4800 aacaagttcc tggcagacgg taatgtgcgg gtgatggcgg aagctccggg tgttgacctg 4860 gccgcagaca aagccccgac cgctgcacag atggaacaga tccgtgagat ggtgggaagc 4920 ctgggcagtg aacagagaaa gttcacgctg gatatttcca ccaccgacgg aagggttgca 4980 gccagcaagg agtacagcgg ccgcattgat gctgaccgtg ttgtgcggga gatcagggac 5040 tattacaaga ccggtgagct gcccgcagag agcagcctgg cacgattccg gtaccagctg 5100 gcggccaaag ccgaacaggc ggaacgggac gcgcggaaga acacccagcg gcaggcaagc 5160 cgggccattg cggacaacag cgcggcgatg gaaacgctgg cccagatgat gggtgtgacc 5220 cacggtgtgc ggatcagcca ggattccatt gacgggctgg cggtgcggtg gacaaaggcc 5280 aacggcagca gggccgaccg gacgaaaatt gccggagaga cccgggcgct ggtggagtac 5340 atgacggcgg acggggccag catgagcaag gccagcgcgc tgtctgagac cattgcggat 5400 gagattctga gcggggcgac ctaccggaat accgagctgt gggacgagta cccggaatac 5460 cacgacttga gctacacggt gaacaaggac ggcccggcca aggcggagct ggtgaagcgg 5520 tacgggacgt ggagcgaagc ggtggcggag gcacggcggc acggtgtgaa gctgcggcag 5580 gcagaaggtg tgcgggacgg caacccggcg gaagtgtatg aatccatcgt caacgacacc 5640 cgggccatgg gcggcaccaa ggaaggggca gcggccttgt tccggggcgc ggcccaggcg 5700 gcaggcgtgg acggcgcggc cagcatggag agcaccgagt ggctggatgt gctgatgaac 5760 gtgcacgatg ccatcaagcc caggatgatg agccgctttg cagatgctgc cgagtacgag 5820 gatgccaaag tggagctggc cgaccggatg ctgggtgata tcctgaacgt accggagatg 5880 accgatgcac aggccatctt tgacgggttc cagcgctggc agcgccaggc tgtggctgct 5940 gccgtgggcg aggagaacgc ggagcaggcg ctgaaggacc tgcggaaggt gcagaaggag 6000 cagaaccggg agttcaaccg gaggatgtat gagaacagcc ggaacggaag ccgggatgaa 6060 gcactgcggc agtggacaga acagcagaag cggaatgaaa aagcagaaaa gctgctggat 6120 cagaatctgg atacgctggg gctggacatc accaactacg gcgacatggc cgaaaagctg 6180 gacgtgctga aggaagccta cgaacgggag tggaaggccg aaaaaaagcg gctgaaggaa 6240 gaacgccagc agatgctgga cgagatccgg ctggaaaaca aacagttgaa gcgggagaac 6300 tggaaccttt cgcaccaggt ggcaggagaa cagcgccggg ctgatcgggc tgagtggcag 6360 ctgatccatc aggaaaacga actgctggaa tgggagcagg aaaaccagcg caaagctcag 6420 gagtggcagg aaaagcaggc ggagcgaaac gcaatcgcca tcactgcagc ccagcagcag 6480 cgggacgagg acattgctat tgccaagaag ctggctgaga agcgggtaca gaaagcccgg 6540 gacggtcggc agaaggacga gctgaaacgg gccatccgga acaatgccac ccagctgaac 6600 cagatggtgc tgcggcctgc aaaggacaaa tatgtgcagc cccggctgat cctgcgggcg 6660 ctggaagtgg caaagctggc ggacatgaca ttgctgaacc agaatgccgt gaaccggctg 6720 gatgcgctgg caaacagcat ccgggccgaa tacggggatg cagaccaccc ggtggtgacg 6780 gagatgagca atgactggga gaagagcggt attgccaacc tgatcgatgc cctgaagaac 6840 gacctgagcg acagcaagga ggcacagctg gaccggctgc gcgggcagtt ggccgaggca 6900 gaagcgctgg aggacagcca gaaggcccgg gaactgagaa gccgtctgga agcccggatc 6960 aaagacgttg aaaacaagcc ctatctgccc atgacggtgg accagatgcg gatgctgaaa 7020 gccattacga ccagcaccct gcacgtgatc cggacggcaa acaagaccct gagcctgcag 7080 caggccgagg cggtggacaa gatcgccgga gaagcggcgg tggaagtgaa ccggagcaag 7140 ggaaatgacg gaaaaatccg gcggatgctg acgaggtaca atctggatat gctgggcggc 7200 acccgggtgt tccggatgct gggcggctac gcaaagaaca gccagatgga gaagctgggc 7260 accatgctga acgacggcca gcggcggcag acggagatcc ttgtggaggg aacccacctg 7320 ttcgacaacg tgacaggcaa aaagaacctg aaacagatgg aacagtttgc aggcaagggg 7380 gcaaagctgg tagaccttgg cctgaaggac aaccggggca aggccgcacc cctcacccat 7440 gcccagatgt gcagcctgta catgcacctg cggaacgccg acagcaagga gcacctgatg 7500 aacggcggct ttaccgtgcc ggatgcagtg gagtacaaca aaggcaacat cgcggaagcc 7560 taccagaagg gccagaccgt gcggatcggg atgctgaccg acagcgaggg caaacccatg 7620 gcggacacca ttgtgagtgc aattgaaaag aacctgaccg actacgaccg ggcatggatc 7680 gggagcatgg agaagttttt cggaagctac accaccgacc tgatcaacga gacgagcatg 7740 aagctgctgg gctacaagcg ggccgtggtg aagaactact accccattgc ggtgaaccag 7800 acggcactgg taaaacagat cgaaggagaa cactgtgatg cgaccatcga gggacggggc 7860 ttcctgaaga accgtgtgaa aagtccacag cccatcctgc tggaggagtg caacaacgtg 7920 gtgcagcgga gcctgcggga cacggcagcc tacgcgggcc tggccccggc catccgggat 7980 gtgaaaaagg tgctgaacag ccggatcgag actgaggacg ggctgaaggt gctgaaggac 8040 ggtatcctgg aggagaagtg gggcagcgat gcagtagact atgtggaaga actgctggtt 8100 gacctgcaga gcccgggaaa gaaaacccgg aagagcagca tgacggcgct gggcaagctg 8160 cggggcaact acgccggggc tatcctgacg ctgaacccgg gcgtggcgat tgcgcaggcg 8220 gcatctctgc ccacggcagg cgcggtactg ggtgcggata ccatggcggc ggtggttccc 8280 tttgtaaaga acttctcacc caagcagcgg gcggcgctgg aagcagagat cgctgaacac 8340 ggggatgcgc tgctgcaata ccgccagcgg ggcagccagc ggggcgagct ggaaagcatc 8400 gggaagaacc tgagtgcggc ggagaaggga atggagaagg tccccaagca gctgacgggc 8460 tggatcaacg gcgtggacga gatcacggtg gcggccctgt gggaaggttc caagcggtat 8520 gtggagcacc ataccaatga gtttgcagag ggtgcagcca cgaaaggcag cgaagcctac 8580 tgggaagctg tgaacaagac ctatcagcga gtgatcgagg agacccagcc caactacacc 8640 accatgcagc gggcaggcat ccagcgcagc gacaacgaac tggtgagaac cctgaccatg 8700 ttcacgaccc agcggttcca gaactacggc atcctggcag atgcggtgat ggactacaat 8760 gcccagcggg agcgcagcca tgcagacccc accgaggaga accgggtaga gctgaaacgg 8820 gccgggaaga acctgaaccg agcggtgacc agccagatcg tgcagacggc agtgtttgcg 8880 gccatgaaga tcggcgcgga cttcctgctg caccggtggg accgggaaca ggacgagaac 8940 ggcgacatta ccgcatggag tttactgaag cggtacgccg acctgtatgt gggaagcgca 9000 gcaggcacgt tcctgtacgg cagcgagctg tacagctttg tgggcaacgt ggccgggggc 9060 aaggactatg atgtggtcag tgccccgaac ctgagtgcta tcaatgacct gggaactgag 9120 gcgatgcggc tgtacaagct gctggccact gacaccggcg agatggacga ggaagagctg 9180 gaagcatacc acgagaagct gcggaaagcg gccctgacct ttatggagga cggactggaa 9240 ctgaaggggc tgccggccgg gaatgcggaa aagctgctgg aagcggcatg gaaatggagc 9300 ggaaatgcag cctatgcggt gacgggcgga aagtacggcg agaagctgag cctgaattcc 9360 ctgccagcca gcgccaccgg gcagtatgac cggctgtaca acgccattgc cgagggggac 9420 acggacaacg ccagcggtgc tatggcgaag ctggaagcca tgggcaagga cgaaaagacc 9480 attgccagcc agctgaagaa ccggctgaag aaatacagcc cagaggtgga gcaggctgca 9540 caggcccgga acgagggcaa agacagccag cgccaagagc tgacaaagca gcttgtgcgg 9600 gaaatgtacg agaccctggg catccgggag ggggtcaaag ctgacgcgga aaagcggaca 9660 tgggtgatcg accttgtgac cgaagccatt gaaagcaagg ccgaggagct gtacaagggc 9720 ggcaccgagg gcagcgtgta cgatgacctg actgaagcgg tggacaccgg caggaccagc 9780 gacgtgcagg atgagatccg gcggctgcgg acggcgggca aggaggacgg cagcatcaag 9840 acgaagatca ccgacgcggt gaaagaggag tatctggcgg gcaacgacca cgaccgggag 9900 aagctggaga agctgctgct gaagctggaa aaggccgacg gcagccagat gtacgaggag 9960 aagaactttg cccagtgggt gaaggacgcg gcaaagaagg aggaacaggc aaagaacagc 10020 aaggatgagt gggcaggggt gaggtga 10047 <210> 12 <211> 1659 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1659) <223> ICBIDGAJ_02242 <400> 12 atgaaaaaga tgatctctcg ccgcaatttc ctgaaggttt gcgccgttgc cggttctgcc 60 gtggcactgt ctgcctgcgg cggcagcaaa aaggccgctg gaccggaccc ctccaacacc 120 gaccagacca gctttgacat cgtgggcggt cagtctgccc tgagccccgg ctacaacgac 180 aacgaggtgc tgaagaagct ggcagataac gtgggcgtta aactcaacta cgagaccatg 240 agcgactccc tcagcgagca ggtgaacatc cgcattgcag gcgaccagct gccggatgcc 300 tttatgggtg tgggcttctc caactacgat atcgccaact acggtgcaga cggcaccttc 360 ctggacctga ccccctatat caacgccgag atcatgccca acctgaccaa gatcctggac 420 gagcacccca acatccgcgc cgctatcacc atgagcgacg gctgcatcta cggtctgccc 480 gctgccgagc agatgggcac tgccggtatc ggtgacgacg aggattacag catcttcacc 540 attccgcagt tctccatgat caacaagcgc tggctggacg agctgggtct ggaagtgcct 600 accacgctgg atgagctgca caccgccctg aaggctttca aggacaacga tatgtctgcc 660 aaggtctacg gtaatgcacc cggcagcacc atccccatgt ccactggctt tgacgagtgg 720 tgctggggtc agaacatctt ctacgcaggc ttcggattca ccaactggcc caacgatgtg 780 tgcaacgatc tggtgctgca gaaggacggc aagtgccgct ttgtctgcgc cgaggacaac 840 taccgcaagg cggtcaccta cttccacgac tggtacgccg agggtctgat ggacgtggag 900 atgttcagtc aggataccaa ccagctgctg gctaagggcg cacagggcta tctgggcgtt 960 tccacctggt ggtacatcga ggagctgatg ggcgattact ccaaggacta tgtgttcctg 1020 cccgtactgg acggcccgga cggcacccac aacgtcaccg tgcgtaccgg cggcggtacc 1080 aacagcggca acctgaacgt gaccaacaag tgccagagcc ctgccaacct gctgaagttc 1140 tttgaccagt ggtatgacgg cgagaccgtg atgcagctgc agtacggccc cattggcgtg 1200 ttcttcaccg agcaggatgc caacggcaag tggaaatcta tcaccgagga agaggccaag 1260 gcaaagtaca acaagggtgc cggtgagctg aaatccacct acgaggtctg gggtcccaag 1320 ctgatcctca gcgagtacta cgacaagtac ttctacatgg aggaccgcgc catcgagcgt 1380 ctgaccgacc tgaaggactt ctggatgccc tttgtggacg acaccaccac ctaccccatc 1440 gactgcgtgt tcaccagcga ggaactggac actatcgacc gctaccgtgc tgattttgag 1500 aacgcagtct ctgaacagga aggtctgtgg ctgaaggatg gcggcccctc tgatgacgag 1560 tggagcgcat acctcgacac cctgaccaac agctgcggca tggacaagct gctggaagtc 1620 taccagaacg cttatgaccg ctacaaggcc aacgtctga 1659 <210> 13 <211> 1341 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1341) <223> ICBIDGAJ_02225 <400> 13 atgatgctgt gcgtcatatc ctactgggta ttatctggcg caaaacggcg gcagatccag 60 cagcttcgct gctgcgttct ccccaccaag ctgttgaaac ggagggatgt ctatctgaaa 120 ttaacacgac acaacggacg agccgggacc cacggcacct ataaccccaa gcacaatgac 180 cgaagtttca accttgccaa cagtgagcac atcgacccgg aacgagccaa gggcaacatc 240 tactgggact gcttccacgg cttccgttcg gctctcgatc cgcaagacct ggacgatctg 300 gcagcgacct tctcggaggt agaacagcaa ttctacgaga accgctattc ggagttcatc 360 gaaaagcaga acgagcgcaa tgccgagatc cggcaaacgg aacgcaaccg ctccattcct 420 gacctgctgt ccagccgcaa gacctgcccg gaagaaacca tctatcagct tggaacaaag 480 gacgaccatg cttcgggcga agttctgctg gcggtcgtga cggagtttat tgaagagttc 540 aaggcgaggt tcggagacca tgttcatgta ctggactggg cgttgcatct ggatgaaagt 600 acaccgcata tccacgaacg tcatgtgttc gactgcgaga acaagcacgg agaggtcgca 660 ccccagcagg aaaaggcgct ggaagcgctg ggcttcgacc tgcccgaccc ggacaagcca 720 ctcagccgcc gcaataaccg caagatcacc tttgatgcag cctgccggaa gatgctgttc 780 gagattgcca agcggcatgg gctggatctg gaggaagaag cggagtacgg caaccgcaag 840 tatctggaaa agcaggattt tgtccttgcc aagcaaaagg agcagcttgc cgcccagcag 900 gacaggctgg acgagctgac cttgaaagtt tcggatatgg agacccttct ggatgatgtt 960 tcggcagcag cctatgacaa ggcggtggag gtcgtgaccg atgtggtgcg caccgagacc 1020 cggaaggaag atatgcggat gatcgaggac acgaagaagt gggtgctgtc cccggaacgt 1080 aaggctccgc agaccacgag agaatacgcc gcccaccgtt tggacaccgt gctggacaag 1140 ttcctcaaga ccatgcagac caccaccgca cgtctgcagg agaagctcct gaagccggaa 1200 gtccggcaga aaggcaagga gcaggtcaag gagaaagcac gagattccgt tctgcagttg 1260 ctgaaccgct tgcaggcgga acaggcacaa aacaaactaa cggcacaacc cagcacacag 1320 gaggggcact cggaaatctg a 1341 <210> 14 <211> 948 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(948) <223> ICBIDGAJ_02240 <400> 14 atgacgcaga cctcgccagc tgctgcacgt cagctggacg ctatcccggt ccaccgcaaa 60 agcctcagcc aacggctgcg ggaaaactgg cagctctatg tgatgctgct gatcccggtg 120 gtgctgacca tcgtttataa gtactggccc atgtacggca ttcagattgc cttccgcgat 180 ttcaaggcaa gccgcggcat caccggcagc gagtgggtcg gcctgtactg gtttgaacgg 240 ttcttcaccg cacccaactg tgtgcgcatg atcaagaata ccgtgctgct gagcctgtac 300 agcctgctgt ggagtttccc catccccatc atcctgtccc tgtgcatcaa ccagctgcgc 360 tttgcaaagt tcaagcgggt ggtgcagacg gtgctgtatg caccccactt catctccacc 420 atggtcatct gtggtatgat caagatcttc ctcagtccgt ccggcggtct gctgaacctg 480 atcctgggca ccagcgtgga cttcctctcg gagagcgccg cattccgtac catctatgtg 540 gcatccggca tctggcagga agctggctgg ggcaccatca tctatatggc ttgtctggct 600 gctgtggata ccagcctgta cgaagccgcc aagatcgacg gtgcatccat gttccagcgc 660 attctgcaca ttgatatccc ggaactggta cccatgatcg tgctgcagct cattatgagc 720 gtaggcaacc tgatgaacgt gggctttgaa aaggtgctgc tgctgcagac cgagctgaac 780 aaggccacca gcgatatcat tgccgtgtac gtctacgaac agggcatcat caacgccaag 840 tacagctatt ccaccgctgt gggtctgttc aacacggtgg tcaacatcat cctgctcatc 900 atcgtcaacc gcatcgccaa gaaggcggca gacgtcagct ttgtgtaa 948 <210> 15 <211> 366 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(366) <223> ICBIDGAJ_00328 <400> 15 atgaaagaga ttacacgtcg aaacttcttg agaatggcca caattgcagt gctcataagt 60 ggaatgggaa tgttgtcgag ttgcggaaaa agtaaagaag agctgatgag tggggattgg 120 tatctccaag gagatgatcg actgtccctt tcgctttatg atgatggtac ttgtcagatt 180 caaggagact acggacaggg aaaatggagc attgtagatg aagatacctt gaaacttaca 240 gatttctatg gagaaacaag aacctatcct attacagctg tcgatgataa ttcgcttgaa 300 cttgagttgc ccaatggtga aactgtcaca tattatcata cggctgaaga agcgttaaaa 360 cattaa 366 <210> 16 <211> 1008 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1008) <223> ICBIDGAJ_02239 <400> 16 atggcaaaac agaacaccgc ccctactatg aaggatgtgg ccaaggaggc aggagtctct 60 ctgggcactg tatccaaggt catcaacggc atcccggtgg gcgaggaata ccgcaaaaag 120 gtggagcagg ccatcaagga actggactac cacctgaacg cctatgcgcg cggcctgaaa 180 agcaaccgca ccaataccat cgccgtcatc ctgcccacca tcgcacatcc ctatttcggc 240 ctgatcgctc attgcatcaa cagctcgctg caaaagcgcg gctaccggat gctgctctgc 300 gataccgact atgacaatga aaaagagcag gaaatgatcc gcatggccga gcagaacaag 360 gtggacggca tcattgccct gacctatgac ccgaagctgg aagtaccctc ggagatcaac 420 tccgtctcca tcgaccggta tctcggcgcc aacatcccct gcgtggcatc agataactac 480 gcaggcgggc ggctggccgc cgaaaagctg atggaaaacg gctgcaggaa gctcgccttc 540 ctgcgcgtcg gttccagcat cgtgggcgag accaacaaac gcaaggacgg ctttgtggcc 600 gcctgtgaag ccgcaggcgt tccttatgaa ataaagaatc tggaagatgc gcgggacggc 660 atcgtctttg accccatggc cgagttcgcg gtgttcctgg acgatcatct gcaggacggc 720 gtgttggagt ttgacggcat cttctgcgtg accgaccgtc tggcctacca gattgttcag 780 ctgctgcgtc tcatggggct tcgggtgccc gaggacgtgc aggtcatcgg ctttgacggg 840 ctgcgcacct tcggcgacat ggattattac tgttccacca tcgttcagcc cgtggacgcc 900 atcgcagaga cctgcgtgga agtcgtgctg aacgagaacc gcgccaatac cccctccctg 960 ctgtgcctgc cggtcagcta tgcttacggc ggcaccacca aggcatga 1008 <210> 17 <211> 312 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(312) <223> ICBIDGAJ_00394 <400> 17 atgaacaaat ctcggcctgt tgcgaccgaa actgtgaaat ctttgaatta tacgaaaaat 60 atcttgcaga ccattccgaa taacgataaa atggaagtgg tcactcaaac caatgccgtc 120 aagtctccga ctgacagcct gaaagccaca acactggtgt acacggtgga ggaaattgcg 180 cagatgctgt ccatcagcct gcgctctgcc tacaacctgt gcaacagcac taccgaattt 240 cgtgttcttc gggtcggcgg aagcatccgc atcccgaaag acagtttcga tgcgtggctc 300 cgggcagctt ga 312 <210> 18 <211> 699 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(699) <223> ICBIDGAJ_02238 <400> 18 atgaccgccc cggaaaaagg ccggtggtac tggttcaaaa actggctgca ttaccactgg 60 ctctacctta ttattgtggc tgtggtgctt tgggtcggca tcagctggct gggcaacgcc 120 ctgcactggg gcgagacact gccggactac cagatcgcct atgtgggcaa aagttctctg 180 ccggaggaca ccgcccacgc cattgaagca gcctttgcgc agtacggcga agatctgaac 240 ggcgacggaa tcgtttcggt caagctcaac cagtatgtca gcgacactga ggacatggaa 300 aacgcttcta cttacgcgct tgcggcgcag atgcagtttc tttccgatat gaacgccgag 360 gaaagctatt ttctgctgct ggatgacccg gcgcattttc aactggacta tcaggcactg 420 gcaaactggg acggcacccc gccgggcgac aacgactata ccgccaccgg aaagaccgtg 480 ccttgggcag actgcccggt gctggccgga tacgaccttg gaacgtatca gaccaccgtg 540 ttgggaacca ccgttactgg cagcagcgca gaactggtaa acggattatt tttaggccgc 600 agggcctttt atgaagagcc cacgaacgaa aaagccgctc atgcccggga aggagcacag 660 cggctatgga agattctgac ggaaggagca actccatga 699 <210> 19 <211> 1386 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1386) <223> ICBIDGAJ_00393 <400> 19 atggcatata ttacgaaacg cggcagctcc tatggtgtcc gctatactta tcaagacgag 60 cagggtaaaa actgcaacaa atgggaaagt ttttccacaa aagaggaggc aacaaatcgc 120 aaaaaacaga tcgaacacga acttgcaaac ggaacgtttc tgattccgtc caccatcacc 180 gtcaaagagt ttttgatgga gtggcttccc aagcaatgca acaagcacaa atgggcacct 240 tgcacctatc aatccaatct gggaacggtc cagaacctca tcattccgta tatcggcgat 300 atgcagatgc aaaagctcaa accctaccat ctggaagatt tgtattctac cctcagcaaa 360 acgccttgcg gccaatatct tgagggcaaa aagcaggtgc tttcggaaaa acagcagcag 420 cggcttctct ctggaacaac catccacgag gtgcaccgcc tgctgcggac ggcgtttcag 480 tatgcggtgg agtggggcat cctcatcaaa agccccgttc cggtggacag ccctaaaaag 540 tcgattcagg agcgtgccat ctgggacgcg gacgagatgt gggccgcact tgccagcatg 600 gaggacccga ttctgcatct ggcagttcat ctgacgctgg tgggtgcact gcgtgaggga 660 gaagtcgctg gtctgacccc ggaagatctt gattttgagg gagcggacgg caccggcaca 720 ttccgcatca acaagtgtat gcagcgcgtc cagaaggcat cgctggcaaa aacaggcaag 780 gactgcatcc tgcaggaatt tgaggataag cgtgagggca gtaccacaac gctggtgctc 840 aaaaagacca aaacagcatc ttccatccga accattttca tgacgacagt gttgaaagag 900 gaattgaagc actggctaag gcgtttggaa atggacgaag ctgttgaccc ggaacgctac 960 cgcaacagtg ggatgctcct gcgcttgccc aatggtctgg cggtggagcc gatcctcatc 1020 cgcaagaagt tcatcaagtg gcaggacgag cacccggagt tcacccgcat tgtgtttcac 1080 ggtctgcggc attccagtgc cacctatcaa ctgatgatct ccggcggcga tgtgaaagcg 1140 gtacagggca caacgggcca tgccagcgct aatcttctgg ttaacaccta tgcacacatc 1200 cagcaggatt cccgcaaaaa gctgggcaaa aagttcgagg aaggcttcta caagccggga 1260 gcaacacctg tgcaggctgc cccggttgaa gcagaaccga ccgtctccgt gtcggcactg 1320 ttggagcttc tgaaggacgc agacccctct gtaaaagcgc agctccgctt ggctttgctg 1380 acctga 1386 <210> 20 <211> 195 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(195) <223> ICBIDGAJ_01337 <400> 20 atgagtgcta tggaccttga gcgcgaggtc atccgtatgg gcgatgtcgg tgtcgctatc 60 gacatggtag acagcaacct tgcggatggc aagctggagc aggctgaacg tgccgttgtg 120 attctccggg aaatcttcaa agcccgcaat gacgggctgc ggaacagctt ctacggaggt 180 gggcggaatg cgtga 195 <210> 21 <211> 621 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(621) <223> ICBIDGAJ_02237 <400> 21 atggaagatt ctgacggaag gagcaactcc atgaaacgga aatggttgtg tgttgtagca 60 ctggcgctgg cggcagtgct ctgtaccggc tgcggtgtga aggatgaaga tttgaaaagc 120 gacccgctgg taaatgcgga tggcaccgcc ccggtgggca aaacactggt tgcccctgct 180 ccgccggagg gctttaccct gctggacaac aaagacatcc ttgcagccaa cggtctgtac 240 tatgcttcct gggtcagcgg agccccccag ccctacgaaa acagcgaggg gaaaaccgta 300 gacctctacg atgcccagct cacgcttgtc gtgcaggaaa acaagacgga ggacaaagcc 360 gcctctgcgg tagagggctg gcagacgctg gcacagcaga actacgatat ttccgacaca 420 cagaccctga ctgccgccgg gcaggaatat acggtcattc agttcaccta tcaggatgaa 480 agcaatccgt atgcgtccgg cgttgcggcc ttcgcacagc gcggcacaag tgcaatcgag 540 tgggaacttt cctgtcagga cagctattcc ggcgatgcgc tgaaagtcct gaccgatttt 600 ctgaacagct gtacttatta a 621 <210> 22 <211> 777 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(777) <223> ICBIDGAJ_02236 <400> 22 atgggactgt tttttccgag tgaccccatc gtccacggcc agcgcgctaa gggtctgccc 60 cgttatcagg agcttctgga acgcgactgg aaaagtttcc tcttcgccga cttcgtgacg 120 ctgggcctgt gcatcccgta tggtctgggc gtgggctacg cgctgctttc ttccagccta 180 ctggtgctgc tcccggtctg cattctgggc gggcttctgg tcggcccggc gatctccggc 240 atgatggatg cgttgttccg cagctaccgg gatgcacccc gcggctggtg ggagaattac 300 tgcaaagcca tgcgccagaa ctggaaagcc tccctcctgc ccggcatcgt attctgcctt 360 gcgctgggca tcgagctgtt cttcggcatg gtgctgttct ctgcggaaca gctgccgggc 420 atcgggacac tggccgtttt ctttgtcgga ctgctgttgc tgctgatgct gttcaccgcc 480 ttttggccgc aagtcgtcct gtttgaggaa agcaacctgc accgactgca aaacgctatc 540 ctgttctgcc tgaaatatgg caagcatgtg atcggcacgg cgatcctgca actgggctgg 600 tggcttctgt tcgtgttgtt tttgccgtgg acgggctttc tggtgccgtt cctcggtgtg 660 tggtttatct ggttcgtctg cttcttcctg ctgtattccg attttgatgc cgcgtatggc 720 attgaggaaa agatccggca gcagttcccg gagcagacac cccgctacga tgaatga 777 <210> 23 <211> 90 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(90) <223> ICBIDGAJ_01867 <400> 23 atgaaggtcg catacgtccg cgtcagcacc gaagaacaga acgaggctcg ccagatcgaa 60 gcgctcaaga agcacagcac cgagaagtga 90 <210> 24 <211> 396 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(396) <223> ICBIDGAJ_02197 <400> 24 atgccaagaa cgaagaaaaa agtgaaatct atcgtaaaga caaaagtaat ctccgcgcga 60 gttaccgaag tagtacatga acttttacac cagcaggccg aagatgccgg aatgacgctc 120 tctgaatttg cagcgcagat gctgatgaaa ggtcgcgtga atacctcgta tgtattctat 180 gtccacccgg acgagatcga agccatcaca cgggagtttt ccgccatcgg gaacaacctg 240 aaccagatcg cggcgttctt caacagcggc ggtatccagt cgcgcgctat gctcgaaaac 300 atcaaccatg cgatttcctg cgtttttgaa atgcgggagc aggtcgcaga aatggcagga 360 aagaactatg gcaatattaa agcacatcgc aagtaa 396 <210> 25 <211> 426 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(426) <223> ICBIDGAJ_01749 <400> 25 atgaaaaatg agatttgtgc ggccatcggc attgtgggcg gggccattgc cagcctgctg 60 ggcggctggg acacggcgct gcagacgctt atcatcttta tggcaatcga ctacatcact 120 ggcctgatcg tggcgggggt gttccacacc agtcccaaga ccaaaactgg cacccttgag 180 agccgggcag gctggaaggg cctgtgccgc aagggtgtga gcctgctggt ggtactggtg 240 gcctgcaggc tggatgctgt catcgggtcg aactttattc gggacaccgt tgtcattgcg 300 tttgtatgca atgagactat cagtatcgtg gagaatgccg gactgatggg tgtgcccatc 360 ccggcggcgc tgactcgtgc tgtggacgtg ctgaagcagc gggcggaaga aaagaacggc 420 agctga 426 <210> 26 <211> 1662 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1662) <223> ICBIDGAJ_02198 <400> 26 atggcaatat taaagcacat cgcaagtaag agttccgatt atggtgctgc actggagtat 60 ctgattttca agcatgacga gcttcggaaa actccgatcc ttgaccagag cggaaatcgc 120 atcatgcggg atgagtttta tctggacggc ctgaactgtg aaccctattc cttcgatgcg 180 gcctgccagc aactgaaccg cgaatatcag aagaacaaaa acaaggatga aattaaatcg 240 cacctttaca tcatcagctt tgatccacgg gacagcacag aaaattgctt gacggggaaa 300 cgggcgcagg agcttggact ggaatatgca aaagctaatt ttccggggca tcaggctttg 360 gtctgtacgc acatggacgg tcataatggc agcggcaaca ttcatgtgca tatcgtaatc 420 aacagtttgc gaaagctgga tgtacctaag cagcccttta tggagcaatc cattgactgc 480 aaggcagggt acaagcacca cgtgacgaac gagtatctaa agcacttgca gaaatccctc 540 atggatttgt gcaaccgtga atttctgcat caagtcgatt tgctgtcacc atccagaacg 600 ggtgtgaccg aagcagagta ttgggcacag cggtggctgg atgagaaaaa acaggaaatc 660 gaaaaggaag ggtttacgcc caacccgaca aaatttcaaa cacagaaaca acttatccgg 720 gatgctgttg ccgctgctcg tgagaaagca atctcgtatg aagattttca aagcatcctg 780 cagaatgaat ataatatttt tgtcaaaaca caacgtggtc gttatagcta tctgccgccg 840 gaacggaaca agttcatatc ggagcgttct ctgggagaaa gcagcaaaag agaatgtctg 900 gaaggattct ttgttcagaa cgccgagaag aatctgcggt acaaggaaga tcccatactg 960 atctttacga ccagaaccag gctgcggctt gttgtggacc tgcaggagaa tgtcaaggca 1020 caggaaaatc tggcctatgc gctaaaggtc aaaatcagca atttgcagaa gatggccgaa 1080 acgctggtat gggtacagga gaacaacatc aacgacctga cggaattgaa cgatctgtgt 1140 aagacagcac aggccaatgc gcaggctgcg tatgatcggc tgtcacagac agaggatgaa 1200 ctgtacaaaa ccaatgagca gattcattat gcgggacagt acctttctac aaaagaggtc 1260 cagcagcaat ttgcgaaggc attttttaag aaaaaattcc gtgcagagca ttccaaggaa 1320 ttggacgcct atgcagaatc cgtgaaatat ttctgggaag aaaacgatgg aaagctgcca 1380 tcgctgaaat ccttgaaaaa acggaaagaa gaactgacca aagaaatcgc ggagaggaaa 1440 aaggcatacg ctcccctgag agaagaatcc cggcgtctgg aaattgcatc ggataacgtg 1500 tacagcatct tccgaaaaac cgatgaaatg aaatccgacc ttgcatggaa acgcgagtgg 1560 gcggcaaaag tccgcgaaaa ggcaaggcag gagcaggttc gacaggaaca gcgcgtacgt 1620 caaccgaaac gtaagaagcg tagctacgat atgagcctgt aa 1662 <210> 27 <211> 915 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(915) <223> ICBIDGAJ_02241 <400> 27 atggcaaaaa acattgcagc atcccgtcaa aagaagcccg gcggtctgtc cgataaggtc 60 agcgacatcg ttctggtggt catctgcgcc gccgtcatgc tcatcgtggc ctacccgctg 120 tactacgttc tggtggcatc cttctcagac ccctatgacg tttacgccgg caagaccttc 180 ctgcttccca gccagttcac cttgaaaggc tatcaggctg tgtttgcaga cagcgcgctg 240 ttctccggtt ttatcaacag catcaaatac accgtcatcg gcacgattta ttcggtggtc 300 atgatctatc tggtggcata tccgctgagc gtcaaagacc tacccggacg caaatacatc 360 agtctgttct tcgtcatcac catgtacttc ggcggcggtc tggtgcctac ttacctcatc 420 gtcaagcaga ccggtctgct gggcagtatg tgggcgctgt tcctgcccgg tgtcgtggcg 480 gtcggcaatg tcatcatcgt ccgcaacttc tttgagaaca acattccccg tgagctgctg 540 gaagctgccg agatcgacgg cgcatccaaa tggacggtgt tcgtcaaaat ggtcattccc 600 ctgagccgtt ccatcatggc agttatggtg gtgtacagca tggtggccta ctggaacgac 660 tggttcaccg ctctgatcta cctgagagcc gatcaggctc cgctgccgct ggtgctgcgc 720 aatatcctga tcaagagctc caccagtgcc agccaatcct ccatggtagc gggcggcttt 780 gcagaactga ataagctgac cgaaatgatc aagtttgctt ccatcatcgt ggcagctgcc 840 cccatgctga tcgtttaccc ctttgtacag aagtattttg aaaaaggctt catggcaggt 900 gccgtgaaag gctaa 915 <210> 28 <211> 1146 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1146) <223> ICBIDGAJ_00537 <400> 28 atgaaaatca cagatgtaaa gcttcgcttt gcaaagcatt atctctttgt tcaggtctac 60 accgatgccg gtatcgtagg tctgggtgaa gcgggcaact ggggctatct gcaggcaact 120 gcagcggcca ttgaaaaatt cgcggactac ctgatcggga aagacccctt ccgcatcgag 180 gacttcaacc agaacttcct gcgttcggtc tatttccgtg gttcggtcat tatgagcgcg 240 atctctgcca tcgacattgc gctgtgggac atcaagggca aggctctgag cgtccccgtc 300 tacgagctgc tgggcggcaa gacccgtgac aaggtgcggg tctacgcctc ggtgatgcac 360 atcaccgagg acaagaacga gctggcggct cagtatcagc agctgcagca gatgggcttt 420 accgcagcaa agatcttctg caacggcccc acaagctctt cggacggcaa gggcgagttc 480 ttctccagcc ggatcgagcg ggaagtggaa aaggtgcgtg tctgccgtga agcggtcggc 540 ccggattttg atttcattct ggaagtccac cgcggcatga ccctgccgga ggcagtcgct 600 ttcggccgcg ccgtcgagcc ttaccgcccg atggttctgg aagatcccgt tccgcccgac 660 aatgtggata ccatggccga ggtcgcaagc aagatcgggg tgccgatcgc caccggcgag 720 cgcgccatcg acctgcggga gtgcgaagtc ctgatgtccc gtcacgcctg ccagtatatc 780 cgccccgatg tatgcgctgt gggcggcatt accaccagca agaagatcgc tgcgctggcg 840 gaagcgcacg atgttctggt gatcccgcac aatccgcttg gcccggtctc gacggccgcc 900 tgcctgcaga tctgtgcttc catcccgaat ctgggcattc aggagcttcc cggcttctgc 960 ctgaacggtg cagaggacaa gatggtaaag gagccgctgc gctatgagaa cggctgtatg 1020 ctcatccccg acgctcccgg catcggtgtg gaactggcag atgacgccga ggaactttac 1080 ccggcaaaag aacgtggcag caatgctgcc cgccgtgcat ttgatggtgc ggtgaaagac 1140 tggtaa 1146 <210> 29 <211> 4659 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(4659) <223> BLCPAMOF_01430 <400> 29 atggccaagg cgcagggact ggccgagacg ctggcgggcg aggtactgga tgaggccacc 60 taccggaaca cggagctgtg gaaccagtac cccgacctgc atgacctgac ctacacggta 120 gacaagaacg gcaaggccaa ggccgagctt gtgaagcggt acggaagctg gacagaggcg 180 gtcgccgagg cccggcgcca cggcgtgaag ctgcggcagg cagagggata ccgggacggc 240 aacccggcgg aacagtacga ggccatcgtg aacgacaccc gggccgtggg cggcgtgaag 300 gagagcgcgg cagcactctt ccgctcggcg gcacaggaag cgggcgtggc gggcgcagcc 360 agcatggaga gcacggaatg gctcgacgtg ctgatgaacg tacacgacac catcaagccc 420 cggatgatga gccggtttgc ggacgctgcc gaatacgagg acgcaaaggt ggaactggcg 480 ggccggatga tcggcgacat catgagccac ccggagatga ccgacgccga ggcggtgttc 540 gagggtatct taaagcataa ccgggaggtg gccgccatgg ctgccggaaa cgaggagcgg 600 gcggctgagg tgacgaaggg actgaagagc gtgcagcagg cccagcggaa ggcttttgcc 660 gaccggatgc gggccaacag ccgcagccag agcgacgagg tcaagagtgt gagccgggcg 720 gagcagcagc tcaacgagaa tctggaaacg ctgggcgcac aggtgagcac ggcggcgggc 780 ctcgacgaga agctgaccgc cctgcgggaa gcctacgacc gggaatggaa ggccgagaaa 840 aaacggatga agctggcccg gcaggagatg ctggatgaga taaagctgga gcggcagcag 900 ctgcgctcgc agatcaacga cctttcccgg caggtggccg gagagcagca gagagccgac 960 cgggcggaac ggcagctcat cttccaggag aacgacattc tggaatggga acaggagaac 1020 cagcggaagg ccgaagcctg gcagcaggaa caggccaagc ggaatgccat tgccatcgag 1080 gcggcgcgcc agcagcggga cgaagacatt gccgtggcca aggcgctggc cgaaaagcgg 1140 gtgcagaaag cccgggacgc ccggaaggcg gacgaactga aacggagcat ccggaacaat 1200 gccgcccagc tcaaccagat ggtgctgcga ccgaagcccg ggaaatatgt gcagaagagc 1260 ctcatcgtgc aggccgctga ggtggcgaag ctggcagaca cggcagtgct gaacaacaac 1320 gccctgacca agctgaccgc cttgcaggac agcatccggc gcagtggaga gatggacgtc 1380 agcatccacg ccgactggga gaacagcggc gtggaaaacc tcatccagac actgcgggac 1440 gacatgaacg ccagcaagca ggcaaagctc gaccggctgc ggcagcagct ggaagaagcc 1500 aaggccctgc cggacggcga caaggccgaa cagctgcggg accggctgcg ccagcgcatc 1560 cgggagacgg agaaccgcac ctatctgccc atgacggtag atcagctgcg gatgctgaag 1620 tccattacgg ccagcacact gcacatcatc cggaccgaga acaagaccct gagccttgcg 1680 agggcagaag aggtggacgg catggccatg aaggccgccc gcgaggtgct gaactcggag 1740 ggcaacggct tcggagagaa attcgaaaag gcgaagggcg cgatgaaccg ctaccagctg 1800 gacatgctgg gcggcacgag aatgttccgg cgcctgggcg gctacaccaa aaacggccag 1860 atggagaagc tggggcagat gctgaacgac ggccagcggc ggcagacgga gatcctggta 1920 gaaggcgaaa gcctgtttgc caacgtgacc ggcaaggaac acctgaaaga ggtggaagct 1980 tttgccgggc cgggggcgga gctggtggac atcggattga aggacagcaa gggcaatgcc 2040 gtgccgctga accacgcaca gctgtgcagc ctgtacatgc tgctgcgcaa cgaggacagc 2100 cgccaccacc tgatgaccgg tggactgacc ctgccggacg ctgcccagta cgccaagggc 2160 aacatcgaga gagcctacca gcgcagccag accgtgatgc tggggacgct ggtgaacgcc 2220 gatggtgtcc cgatggccga caccattttg cagacggtac aggacgccat gacggactat 2280 gaccgaaact ggtgcaagga catggaggac tttttcgggc ggtacaccac gaacctcatc 2340 aacgagacca gcatgaagct gctgggctac gaccgggcca ccgtgaagaa ctactacccc 2400 atcgcggtag accggagcac gctggcgacg gagattgagg gcgtgaagat ggatgccacc 2460 atcgagggca ggggcttttt gaaggagcgc gtgaagagtg acaagcccat tttgctggaa 2520 gagtgccaga acgtggtaaa gcggagcctg cgggacacgg cagcctatgc gggccttgcg 2580 gcccccatcc gggacgtgca gcgggtgctg aacagcaccg tggagacggc agagggcatc 2640 ggtgtgctga aggacaagat catcggcgag aagtggggaa aggagacggt aaactacatc 2700 aacgacctgc tgaccgacct gcagaccacg cggcgcaagc gcagcagcac catgagccgg 2760 gcgctcgacc ggatgcgggg caactacgcc ggggccatcc tgaccgtgaa cccgggcgtg 2820 gccatcgcgc aggcggccag tctgcccacg gcgggcgctg tgctgggagc agacaccatg 2880 gcggcggtgc tgcccttcgt gaagaatttc tcgggcaagc agcgggccgc ggtggaagca 2940 gagatacgcc agcacggcga cgccctgctg caataccgcc tgcgcggcac caagcgggga 3000 gagatgagct ccatcggcgc gcacaaaaac cttgtggcca aagcgtcgga agccatgcct 3060 gctgtgaccg gctggatcac cggcatggac gagatcacgg tggcggcgct gtgggagggc 3120 gcgaagcggt atgtggagca ccatacggca gaattcagcg agggtgccgc ggagaagggc 3180 agcgaagcct actgggaagc cgtgaacaag atgtaccagc gggtcatcga ggagacgcag 3240 cccaactaca ccaccatgca acgggcgggc atccagcgca gcgacaacga gtttgtaaag 3300 acgctgacca tgtttaccac ccagcgattc cagaactacg gcatcctggc cgacgccgtg 3360 ggcgactaca aggctcagaa ggcgcggtac gctgccgacc agagcgcgga aaacaaagcc 3420 gaggtacagc gggccggaca gggcctgcgc caggcggcgg caagccaggt cgtgcagacg 3480 gcggtgtttg ccctcatgaa gatcggcgcg gactttttgc tccaccggtg ggacaaggag 3540 caggacgaga acggcgacat cacggcggcc agcgtgggca agcggttttt cgacctgtac 3600 actgaaagtg cggccggaaa ctttttgtac ggctcggaga tctacagcgc cctgaccaac 3660 gcccgggacg gcaaggacta tgacgtggtg agcgccacca acatcagcgc ggtgaacgac 3720 ctgtttgctg cctttaccaa gaccgtcaag ctgctgcgga cggacactgg cgagatgagc 3780 gaggaagagc tgacagcaca ccaccagaag ctgaacaagg cggtgctgaa ggacatccag 3840 tgcggccttg aactctacgg cgtcccggcg gcgaacatcc ggaaggtgat gcaggcgttt 3900 gaaggctact gggaggatgc acaggccatc ggcagaggcg aagggtttag ctttaactct 3960 gcaccctctt cggccaccgg gcagtacgac cggctgtaca acgccatcca gagcggggac 4020 agcgaggagg ctgcggcggc gatgaagaaa ctggaacaga tgaataagac ggacaaggtg 4080 gacggcgagc tggcaaggcg gctgaagcag tacgacgccg acgtgctggc ggcggccaag 4140 gcccggaacg ccgggaaggc ccgggccgag gaaaaggccc gaaaggccgt atttgagaag 4200 ctgcgggagg ggctggacgt cgcccctgtg acagacaggg ccaagggcaa aacggacgcg 4260 gcccggcggg cgcagctcat cgaccttgtg aacaaggcgg tggacggcaa ggcagacgaa 4320 ctgctggcgg gcagcaagga cggcagcata tacgacgcgc tcctggacga agtgaaaaat 4380 ggccgggcgg aggacgtgca gacggagatc aaccggctgc tgacggcagg caagaagaaa 4440 agcagcatca aggacaagat caccgaggcc gtgaaggagg agtatctggc gggcagcgac 4500 cgggaccggg agaagctgga gaagaagctg ctggccctcg aggacgcaga cgaaaacccg 4560 ctgtacgagg aaaagaactt tgcgcagtgg gtaagcgctg cggacaagaa ggccgagaag 4620 gcgaaggacg agaagaactg gtgggagggg gtgaaataa 4659 <210> 30 <211> 360 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(360) <223> BLCPAMOF_01513 <400> 30 gtggtggaga agggcctgga cgttggcttt gccttcgatg gtgacgctga ccgctgcctg 60 tgcgtggatg agaagggtaa tgtcatcact ggcgaccata tcctgtatat ctatggctgc 120 tatatgaaag agcatggcaa gctgctgacc aatactgtgg ttacgactgt catgtccaac 180 tttggtctgt acaaagcgtt tgatgagcaa ggtatcggtt acgccaagac tgctgtgggc 240 gacaagtacg tatacgagta catggcgaag aacggctgtc gtatcggtgg tgagcagagt 300 ggtcatatgc ggataatgac agtctgttca gtttcattac agtccaacag caagcgatga 360 <210> 31 <211> 402 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(402) <223> BLCPAMOF_02753 <400> 31 atgaaaaaaa taaaaatgag cgatattttg ctgacggttt gtgcgatagc tatcgtttgt 60 ggtatcggaa gtttgacact tcgcggaaag aagactacag aaaaactcat aatcggagat 120 tggtatcagc agtggtcgga tagcttgact ttttcaattt atgatgacag aacggttaat 180 gttcctggtt cctatggtct tggaaaatgg tctctagtaa acgataatca gctgatcctt 240 tcggattttt atggagaaac gattatcttg aagattgaga atattgatgc cgacaatatg 300 gaggtccgac aggtaatcga tggaaaagaa agtcaagaat caatcacatt ctggcacacc 360 gcagatggcg cacaaacgat acgagttaag ggctaccatt aa 402 <210> 32 <211> 180 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(180) <223> BLCPAMOF_00329 <400> 32 atgaccgtaa aacgcgaaaa ggcattccgc aacgccattg catccacacg gatggagggc 60 ctctcttttt ccaaaaaatc ggagcaggac tgtctgcgct atctggacgg tcatcttgac 120 gccgccaccc tcgtccgtga ggttctgcgg cagccacagg acactgcggc ccagaggtaa 180 <210> 33 <211> 1386 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1386) <223> BLCPAMOF_00265 <400> 33 atggcatata ttacgaaatg cggcagctcc tatggtgtcc gctatactta ccaagatgag 60 cagggtaaaa actgcaacaa atgggaaagt tttcccacga aagaggaggc aacaaatcgc 120 aaaaaacaaa tcgaacatga actggcaaac ggaacgtttt tgattccgtc caccatcacc 180 gtcaaagagt ttttgatgga gtggcttccc aaacagtgca acaagcacaa gtgggcaccg 240 cagacctatc aatccaatct gggaacggtc cagaacctca ttattccgta catcggcgat 300 atgcagatgc aaaagctcaa accctaccat ctggaagatt tgtatgccac tctcggcaaa 360 atgccctgcg gccagtatta tgagggcaaa aagcaggtgc tttcggaaaa acaacagcag 420 cggcttctct ccggcacgac catccacgag gtacaccgcc tgctgcggac agcgtttcag 480 tatgcggtgg agtggggcat cctcatcaaa agccccgttc cggtggacag ccctaaaaag 540 tcaattcaag agcgtgccat ctggaatgca gatgagatgt gggccgcact tgccagcatg 600 gaagacccga tcctgcattt ggctgttcac ctcacactgg taggcgcact gcgcgagggt 660 gaagttgctg gcccgactcc ggaagatctt gattttgagg gagcggacgg cacaggcacg 720 ttccgcatca acaagtgtat gcagcgtgtc caaaaggcat cgctggcaaa aacgggcaag 780 ggctgcatct tgcaggaatt tgaagataag cgtgagggca gcaccacaac gctggtgctc 840 aaaaagacca aaacagcatc ttccaaccga accatcttca tgacagccgt gctgaaagag 900 gaactgaaac actggctaaa gcgtttggaa atggacgaag ccgttgaccc ggaacgctat 960 cgcaacagcg ggatgctcct gcgcttaccc aatggtctgg cggtagagcc gatcctcatc 1020 cgcaaaaagt tcatcaagtg gcaggacgag cacccggagt tcacccgcat tgtgtttcac 1080 ggtctgcggc attccagtgc cacctatcaa ctgatgatct ccggcggtga tgtgaaagcg 1140 gtgcaaggca caacaggcca cgccagtgcc aatctgctgg tcaacaccta tgcacacatc 1200 cagcaggatt cccgtaaaaa gctgggtaaa aagttcgagg aaggcttcta caagccggga 1260 gcaacacttg tgcaggctgc cccggttgaa gcagagccga ccatctccgt gtcggcactg 1320 ttggagcttc tgaaggacgc agacccctct gtaaaagcgc agctccgctt ggctttgctg 1380 acctga 1386 <210> 34 <211> 312 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(312) <223> BLCPAMOF_00266 <400> 34 atgaacaaat ctcggcctgt tgcgaccaaa actgtgaaat ctttgaatta tacgaaaaat 60 atcttgcaga ccattccgaa taacgataca atggaagtgg tcactcaaac caatgccgtc 120 aagtctccga ctgacagcct gaaagccaca acactggtgt acacggtgga agagattgcg 180 cagatgctgt ccatcagtct gcgctctgcc tacaatctgt gcaacagcac taccgaattt 240 cgtgttcttc gggtcggcgg aagcatccgc gtcccgaaag acagtttcga tgcgtggctc 300 cgggcagctt ga 312 <210> 35 <211> 267 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(267) <223> BLCPAMOF_00907 <400> 35 atgctttacc catttatgac attgaacgat ggtacggaaa tcgtttattc ctcaccgatt 60 cagaatggaa atcaggaaca ggtaaaggtg cagatcgaga cgcctgtaga aaatggcttc 120 aagtctgcga catgtatcct gccgggctat ctgtggacga acaatggcta ttccgaaatc 180 gagatggcaa gcctgaaaga actgatcaaa tcgacagcac atctgctgat tcgtttctct 240 cgtgaggggg gaatcgagag tgcctag 267 <210> 36 <211> 915 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(915) <223> BLCPAMOF_02129 <400> 36 atggcaaaaa acattgcagc atcccgtcaa aagaagcccg gcggtctgtc cgataaggtc 60 agcgacatcg ttctggtggt catctgcgcc gccgtcatgc tcatcgtggc ctacccgctg 120 tactacgttc tggtggcatc cttctcagac ccctatgacg tttacgccgg caagaccttc 180 ctgcttccca gccagttcac cttgaaaggc tatcaggctg tgtttgcaga cagcgcgctg 240 ttctccggtt ttatcaacag catcaaatac accgtcatcg gcacgattta ttcggtggtc 300 atgatctatc tggtggctta cccgctgagc gtgaaagacc tgcccggacg caagtacatc 360 agcctgttct tcgtcatcac catgtacttc ggcggcggtc tggtgcctac ttacctcatc 420 gtcaagcaga ccggtctgct gggcagtatg tgggcgctgt tcctgcccgg cgtggtggct 480 gtgggcaacg tgatcatcgt ccgcaacttc ttcgagaaca acattcccag agaactgctg 540 gaagccgccg agatcgacgg tgcctccaag tggaccgtct ttgtaaagat ggtcattccc 600 ctgagccgtt ccatcatggc agttatggtg gtgtacagca tggtggccta ctggaacgac 660 tggttcaccg ctctgatcta cctgagagcc gatcaggctc cgctgccgct ggtgctgcgc 720 aatatcctga tcaagagctc caccagtgcc agccaatcct ccatggtagc gggcggcttt 780 gcagaactga ataagctgac cgaaatgatc aagtttgctt ccatcatcgt ggcagctgcc 840 cccatgctga tcgtttaccc ctttgtacag aagtattttg aaaaaggctt catggcaggt 900 gccgtgaaag gctaa 915 <210> 37 <211> 195 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(195) <223> BLCPAMOF_00483 <400> 37 gtgaaagaag ttccgatttg gcaaaagagt aatctgacct tggaggaagc ggcggcttac 60 tctgggattg gtatcaataa actgcggtca atgaccgata gcgatgaatg caagttcgtc 120 ctttggaacg gaaccaaacg gctgatcaaa cgccgtaagc tggacgaata tctggacaag 180 gcattctcga tctga 195 <210> 38 <211> 1158 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1158) <223> BLCPAMOF_00482 <400> 38 atgatgctgt gcgtcatatc ctactgggta ttatctggcg caaaaaggcg gcagatccag 60 cagcttcgct gctgcattct ccccaccaag ctgttgaaac ggagggatgt ctatctgaaa 120 ttaacacgac acaacggacg agccgggacc cacggcacct ataaccccaa gcacaatgac 180 cggagtttca accttgccaa cagtgagcac atcgacccgg aacgagccaa gggcaacatc 240 tacggggact gcttccacgg cttccgttcg gctctcaatc cgcaagaccc ggacgatctg 300 gcagcgacct tctcggaggt agaacgacaa ttttacgaga gccgctattc caattttgtg 360 gaaagtcaga acgagcgcaa tgccaagatt cggcacacgg agcgtaaccg aaccatagag 420 gacttgcttg aaggtaagaa aacctgcccg gaagaaacca tctatcagct gggaacaaag 480 gacgaccatg cttcgggcga agttctgctg gcggtcgtga cggagtttat tgaggagttc 540 aaggcgaggt tcggagacca tgttcatgta ctggactggg cgttgcatct ggatgaaagt 600 acaccgcata tccacgaacg tcatgtgttc gactgcgaga acaagtatgg tgaggtggca 660 ccccagcagg aaaaggcact ggaagcgttg ggttttgagc tgcctgaccc gggcaagccc 720 ctcagccgcc gcaacaaccg caagattact ttcgatgccg cctaccggaa gatgctgttt 780 gacattgcca aacggcatgg gctggaattg gaggaagaag cggagtacgg cagccgcaag 840 tatctggaaa agcaggattt cattcttgcc aagcagaagg cgcagcttgc tgcccagcag 900 agcaagctgg acgaactgac cctcagggtc agcgacatgg aaacgctgat cgacgaagtt 960 tcggctgcgg cctacgacaa ggcggtggag gtagtggcgg acgtggtacg caccgagacc 1020 cgaaaggaag atatgcggat gatcgaggat acgaaaaagt gggtgttgtc cccggaacgc 1080 aaggctccgc agtccacacg ggagtacacc gcaaaacatc tggatagcgt gctggacaag 1140 ttcctcaaga ccatgtag 1158 <210> 39 <211> 279 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(279) <223> BLCPAMOF_00908 <400> 39 gtgcctagtt tgttccggtt gttcggttat gtgattttct tttggagcaa cgagggggca 60 ccgctggaac ctgtccatgt tcatgttgcg aagggtgtgc cgaatgccaa tgcgacaaaa 120 atctggatga cagaagcggg tggctgtatc atcgccaata ataattcgaa gataccgact 180 cgaacgttga acgctattgt ggatgttctg gaaagccgtt ccagttacat cattgcacag 240 tggaatgacg tgttcggaga gtcgaaattc tattgctaa 279 <210> 40 <211> 1233 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1233) <223> BLCPAMOF_00484 <400> 40 atgcaaagac gtaaagataa taaaggccgt gttttgaagg atggcgaggt ttaccgcaag 60 agcgacgggc tatatatgta ccgttggact gctaaaaacg gaaaacgcca taccatctat 120 gatgcaacct tggaggggct gcgggaaaag gaagaaaaaa tccagcatga cttggcagag 180 ggcatccgta tgccggagtg caatttgacc ctgaacgatc tgtttgaact gtggcgtaaa 240 aacaaggtgg gcttgaaaga gcacaccttc gccaattacg tttatatgta caatcggttt 300 gttcgggatg aaatcggcat gatgaagctc aaggacattc gcaagtcgga tatccgcagc 360 tactacaatg gcatcgtccg caacggcaag atggcgttga acacgctgga aaccgtccag 420 aatgttcttc atcaggtctt tgcggtggcg gtggacgatg agtacatccg tgtgaatccc 480 acggatggtg tcctgacggc tataaaagcc gcccaccagt acgaaacgcc caaacgccac 540 gctctgaccc tgccccagca gcaggcgttt ctgaatttca tcaagaaaac gccgaagttc 600 cagcattggc tcccgatgtt caccttcatg ctgggtaccg gatgccgcat ctcggaaacg 660 gttggcctgt gctggggtga catcgacttc gagagtgggt ttatcaccat ccagcacaat 720 ctggtgtacc atgaccacga ggtcggtggc tgctatttca ccatgtctac ccccaagact 780 gccgccggta agcgggcaat tcccatattg cctgaagttc gaaaagcgtt ggagcaggaa 840 cgaaccaatc agcaggaact ggaactggtg tgtgagtacg aaatcgatgg tatctcggac 900 tttgtgttcc tgaaccgctt cggtcagccg cagaacccgc agacggtcaa ccgcgccatc 960 aagcgcatca gcgtggcata caacgaagcc gaactggaaa aggccgaaaa ggaaaagcgg 1020 gagccgcagc tgttgccgcc tttctcctgc cataatctcc ggcacacatt ctgcacccgg 1080 ctgtgtgaaa atgaaaccaa cctgaagatc attcaggaca tcatgggaca caaggacatc 1140 agcaccacga tggagattta cgcggaagcc accaaggaag ccaaagccca ttcctttgca 1200 aatctgaacg gtaaactggg catttcggtc tga 1233 <210> 41 <211> 432 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(432) <223> BLCPAMOF_01424 <400> 41 atgaaggata gcatttgcac cgtcatcggc ctcatcggcg ggaccattgc cgccttattc 60 ggcggctggg acactgccct gcagacgctg gtcatcttta tggccatcga ctacatcacc 120 ggtctggtgg tggcaggcgt gttccacgcc agccccaaga ccaagaccgg cgcgctggaa 180 agcaaggctg gctggaaggg cctcatccgc aagggcgaga cgctgctcat cgtgctggtg 240 gcctgccagc ttgatgctgt catcggcggc agcttcgtcc gcgacgcggc gatcatcggc 300 ttttcggcca acgaggccat ctccatcgtc gaaaatgccg gcctgatggg tctgcctatc 360 cccgcagcca tcaccaaggc catcgacatc ctcaaacagc gggccgagac gcccgagaaa 420 ggcaagaact ga 432 <210> 42 <211> 1659 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1659) <223> BLCPAMOF_02128 <400> 42 atgaaaaaga tgatctctcg ccgcaatttc ctgaaggttt gtgccgttgc cggttctgcc 60 gtggcactgt ctgcctgcgg cggcagcaaa aaggccgctg cacccgatcc ttccaacacc 120 gaccagacca gctttgacat cgtgggcggt cagtccgccc tgagccccgg ctacaacgac 180 aacgaggtgc tgaagaagct ggcagataac gtgggcgtta aactcaacta cgagaccatg 240 agcgactccc tcagcgagca ggtgaacatc cgcattgcag gcgaccagct gccggacgcc 300 tttatgggtg tgggcttctc caactacgat atcgccaact atggtgcaga cggcaccttc 360 ctggacctga ccccctatat caacgccgag atcatgccca acctgaccaa gatcctggac 420 gagcacccca acatccgtgc agctatcacc atgagcgacg gctgcatcta cggtctgccc 480 gctgccgagc agatgggcac tgccggcatc ggtgacgacg aagattacag catcttcacc 540 attccgcagt tctccatgat caacaagcgc tggctggacg agctggggct ggaagtgccc 600 accacgctgg acgagctgca caccgccctg aaggccttca aagacaacga tatgtccgcc 660 aaggtctacg gcaatgcacc cggcagcacc atccccatgt ccaccggctt tgacgagtgg 720 tgctggggtc agaacatctt ctacgcaggc ttcggattca ccaactggcc caacgatgtg 780 tgcaacgatc tggtgctgca gaaggacggc aagtgccgct ttgtctgcgc cgaggacaac 840 taccgcaagg cggtcaccta cttccacgac tggtacgccg agggtctgat ggacgtggag 900 atgttcagtc aggataccaa ccagctgctg gctaagggcg cacagggcta tctgggcgtt 960 tccacctggt ggtacatcga ggaactgatg ggcgattacg ccaaggacta tgtgttcctg 1020 cccgtgctgg acggcccgga cggcactcac aacgtcaccg tgcgtaccgg cggcggtacc 1080 aacagcggca acctgaacgt gaccaacaag tgccagagcc ccgccaacct gctgaagttc 1140 tttgaccagt ggtatgacgg cgagaccgtg atgcagctgc agtacggccc catcggcgtg 1200 ttcttcaccg agcaggacgc caacggcaag tggaagtcta tcaccgagga agaagccaag 1260 gcaaagtaca acaagggtgc cggtgagctg aaatccacct acgaggtctg gggtcccaag 1320 ctgatcctca gcgagtacta cgacaagtac ttctacatgg aggaccgcgc catcgagcgt 1380 ctgaccgacc tgaaggactt ctggatgccc tttgtggacg acaccaccac ctaccccatc 1440 gactgcgtgt tcaccagcga ggaactggac accatcgacc gctaccgtgc ggattttgag 1500 aacgcagtct ctgagcagga aggtctgtgg ctgaaggacg gcggtccctc cgacagcgag 1560 tgggcagcct atctggacac cctgaccaat agctgcggca tggataagct gctggcagct 1620 taccagggcg catacgaccg ctacaaggcc aacgtctga 1659 <210> 43 <211> 399 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(399) <223> BLCPAMOF_00817 <400> 43 ttgaagaaaa aatacaacac accccaccgc tgccatgtgg tcaaaacccg catgaccgag 60 gaagaatacg ccgactttac cgagcggctg aaacactatg acatgagcca agccgaattt 120 atccggcaag ccattacacg ggcgaccatt cgccccatcg ttaccgtttc cccggtcaat 180 gatgaactgt tgtccgccgt tggcaggctg accgccgaat acggaaaaat cggtggcaac 240 ctcaatcaga ttgcccgcgc cctcaacgag tacggcacac catacaacgc cctgtccgtt 300 gaagtccgcg ccgccatttc tgaccttgct gccttgaagt ttgaagtcct gcgaaaggta 360 ggtgacgctg ttggcaacat tcaaacatat cagctctaa 399 <210> 44 <211> 207 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(207) <223> BLCPAMOF_00378 <400> 44 atgaaccgtg ttgacgtgga aagtgctgtg atcgctatgg gggatgtggc tgtgtgtatc 60 aagatggtgg acgacgcgac cgaggagggg aacgcggtgc agcagggccg agcggtgcaa 120 gtccttatgg acatcttcaa ggccagatat gccgctcttg tgtcctgtgt tcagggcgac 180 cagagcgccg cgcagggcag tttttga 207 <210> 45 <211> 396 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(396) <223> BLCPAMOF_01019 <400> 45 atgccacgga cgaagaaaaa agtgaaatct atcgtaaaga caaaagtaat ctccgcacga 60 gttacagaag tagtacatga acttttacac cagcaggccg aagatgcagg aatgaccctc 120 tctgaatttg cagcgcagat gctgatgaaa ggtcgcgtga atacctcgta tgtgttctat 180 gtccacccgg acgagatcga agccatcaca cgggagtttg ctgccatcgg gaataatctg 240 aaccagatcg cgatgttttt caacagcggc ggtatccagt cgcgcgctat gctcgaaacc 300 attaaccatg caattgcctg catttttgaa atgcgggagc aggtcgcaga aatggcagga 360 aagaattatg gcaatcttaa agcatatcgc aagtaa 396 <210> 46 <211> 777 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(777) <223> BLCPAMOF_02134 <400> 46 atgggactgt tttttccgag tgaccccatc gtccacggcc agcgcgccaa ggggctgccc 60 cgttatcagg aacttctgga acgcgactgg aaaagtttcc tctttgccga cttcgtgacg 120 ctgggcctgt gcatcccgta tggtctgggc gtgggctacg cgctgctttc ttccagccta 180 ctggtgctgc tcccggtctg cattctgggc gggcttctgg tcggcccggc gatctccggc 240 atgatggatg cgttgttccg cagctaccgg gatgcgcccc gcggctggtg ggagaattac 300 tgcaagggca tgaaacagaa ctggaaatcc tccctcctgc ccggcatcgt attctgcctt 360 gcgctgggca tcgagctgtt cttcggcatg gtgctgttct ctgcggaaca gctgccaggc 420 atcgggacac tggccgtttt ctttgtcgga ctgctgttgc tgctgatgct gttcaccgcc 480 ttttggccgc aagtcgtcct gtttgaggaa agcaacctgc accgactgca aaacgccatc 540 ctgttctgcc tgaaatatgg caagcatgtg atcggcacgg cgatcctgca actgggctgg 600 tggcttctgt tcgtgttgtt tttgccgtgg acgggctttc tggtgccgtt cctcggtgtg 660 tggtttatct ggttcgtctg cttcttcctg ctgtattccg attttgatgc cgcgtatggc 720 attgaggaaa agatccggca gcagttcccg gagcagacac cccgctacga tgaatga 777 <210> 47 <211> 1149 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1149) <223> BLCPAMOF_01009 <400> 47 atgataaaga atgttgtgtt aaaaaagtcg ttaaaaaata gtgttttcaa agtcgttagt 60 ttgctgaata atgtagtgcc aaaacataac aattatattt tgttatattc aggcaataag 120 ggaattagtt tcaatttgat tccgctccga gattatctgc ttttaaacgg atatgatacg 180 aataatagaa tcatttgtgg aattgaagat atgaaatatg cggaaactga taactgcaca 240 tatgttacac atgttaaagc tatattttat tatctaaaat ctaaatatgt tttctataca 300 gctgggcagc tgcctattaa accgtcaaaa agtcaaaaag tcattcattt acagcatgga 360 atcacgttta aaacttgtgg aaagcttact cacattaata acggaaatga atttttcttt 420 acggattgtt tggctacatc gaatatatac aagcctattt atagtaaagc ttttggttgc 480 tcggaagaaa atatatatat aaacagtgaa cctgtgacgg atgtattttt taatgggtat 540 aaaaaatatg atttaggtaa ttacaacaag ataatattgt ggacaccaac gtttcggcaa 600 tctgattatt tgggatatga tgattcagaa acagaagaat tattaccact gtttgaagaa 660 aaagattata gtaggcttaa tgaaatactc aaagaatata attttcttct tatggtaaaa 720 atacatccgt ctcaagactt gagtagatat agtaaattga aatactctaa tttgcaaata 780 ctatcaaatg atgattttaa tcagatggga atggagatat ataatctatt gccccaggta 840 gatgctatta ttggagacta ttcatctctt tgtatgcagt ctttgttgtt ggataaacca 900 atggcatatg tagtacctga tatggaagaa tattctaaac gaagaggatt tgcatttgat 960 ccaccgacag actatatgcc tggagatttg ataaaagata aagatcagtt ttatcagtgg 1020 ttggatgatt ttaataaagg aatcgataaa tatgaaagta tcagaaataa agtaaaaaat 1080 aaagttcatc tttattcaga tggtaaatcg tgtgagcggc ttgtggaata ttgtggaata 1140 aataagtga 1149 <210> 48 <211> 1662 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1662) <223> BLCPAMOF_01020 <400> 48 atggcaatct taaagcatat cgcaagtaag agttccaact atggtgctgc actggagtat 60 ctgattttca agcatgatga gcttcggaaa actccgatcc ttgaccagaa cggaaatcgt 120 atcatgcgag atgagtttta tctggacggt ctgaactgtg aaccctattc ctttgatgcg 180 gcctgccagc agttgaaccg cgagtaccag aaaaacaaaa acaagaatga aatcaaaagc 240 caccattaca tcatcagctt tgatccacgg gacagcacag aaaattgttt gacggggaaa 300 cgggcacagg agcttgggct ggaatacgca aaagcaaatt ttccggggca tcaggcattg 360 gtctgtacgc acatggacgg tcacaatggc agcggcaaca ttcatgtaca tatcgtaatc 420 aacagcttgc gaaaattgga tgtgccccag cagcccttta tggagcgatc cattgactgc 480 aaggcagggt acaagcacca cgtgacgaac gagtatctaa agcacttgca gaaatccctc 540 atggatttgt gcaaccgtga atttctgcat caggtcgatt tgctgtcacc atccagaacg 600 ggtgtgaccg aagcggagta ttgggcacag cggcggctga atgagaaaaa acaggaagtc 660 gaaaaggatg gatttacgcc aaatccgaca aagtttcaaa cacagaaaca gcttatccgg 720 gatgccgttg ccgtcgcccg tgagaaagca atctcgtatg aagattttca aaacatcctg 780 caggatgaat ataatatttt tgtcaaaaca caacgtggtc gttatagcta tctgccgccg 840 gaacggaaca agttcatatc ggagcgttct ctgggagaaa gcagcaaaag agaatgtctg 900 gaaggattct ttgttcagaa cgccgagaag aatctgcggt acaaggaaga tcccatactg 960 atctttacga ccagaactag gctgcggctt gttgtggacc tgcaggagaa tgttagggca 1020 caggaaaatc tggcctatgc actaaaggtc aaaatcagca atttgcagaa aatggccgaa 1080 acgctggtat gggtacagga gaacaacatc aacgacctga cggaactaaa cgatctgtgt 1140 aagacagcac aggccaatgc gcaggctgcg tatgaacgac tgtcacaggc agaagatgaa 1200 ctgtacaaaa tcaatgaaca gattcattat gcggggcagt acctttctac aaaagaggtt 1260 cagcagcaat ttgcgaaagc aattttcaag aagaaattcc gtgcagagca ttccaagaaa 1320 ttggatgcct atgcagaatc cgtgaaatac ttccgggaag aaaacgatgg aaagctgcca 1380 tcgctgaaat ctttgaaaaa gcggaaagaa gaactgacca aagaaatcgc ggagaggaaa 1440 aaggcatatg ctcccctgag ggaagaatcc aggcgtttgg aaattgcatc ggataatgtg 1500 tacagcatct tccaaaaaac aaatgagatg aaatccgacc ttgcatggaa acgcgagtgg 1560 gaggccaatg tccgcgaaaa ggcaaggcag gagcaggttc gacaggaaca gcgcgtacgt 1620 caaccgaaac gtaagaagcg cagctatgat atgagcctgt aa 1662 <210> 49 <211> 384 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(384) <223> BLCPAMOF_02754 <400> 49 atgaaaaata tcacgcgacg tggattccta cagcttacgg cggcgacggc tctggtgtgt 60 gcaacagctc cgctgacggg atgcgggaag aaaaatatta aaaaacttgt actgggtgac 120 tggtacatgg aaggctatag ccgactggag tacgcaatat atgatgatgg aagctgtcag 180 gttcggagtg ggtatggcct tggaaaatgg tcggtcgtag atgacgacaa acttagaatt 240 tcagattttt atgggcagac actgatttac aaaattgaaa aaatcagtaa aaagtcaatg 300 acgcttagac tgatttggga tggaaaggaa agcgaaacaa cagatacatt ctaccacacg 360 gcagaagagg cagaaaaaca ttga 384 <210> 50 <211> 579 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(579) <223> BLCPAMOF_00910 <400> 50 atgaaggtcg catatgtccg cgtcagcacc gaagaacaga acgaagcgcg tcaaatcgaa 60 gcactcaaga aacacagcat cgagaagtgg ttcaccgaaa aagtcagcgg caagagcatg 120 gacaggcccc aactccaagc aatgctcgac tatgtacggg agggcgatac cgtctacatc 180 cacgacttta gccgcctcgc acgcagcacc aaagacctgc tcgaaatcgt ggagcggttg 240 caggccaagg aagtgcatct cgtcagcaac aaagagaatc tggacaccgg cacacccacc 300 ggcaagctga tgctgacgat gattgcggcc atcaacgagt ttgaacggca gaacctgctg 360 gacagacaac gggaaggaat cgccatcgcc aagcggaatg gagtctacaa gggacgcaag 420 aaggtcacca tacccgataa cttttctgcc ctatatgacc ggtacacccg ccgggagatg 480 aacaaaggcc aacttgcaga agctcttcat gtcactcgtc cgacgctgaa acggatgata 540 cgggagcatt tatcagcaaa aaatccccaa aattcttaa 579 <210> 51 <211> 543 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(543) <223> BLCPAMOF_00917 <400> 51 atgaagagaa gagtatgctt cctactgcta ttgtccgtat tcatgtgcag tatcctaaca 60 gcttgcagcg gttctggtgg tgctgtctca ggacccaata attcttattc atcgggtact 120 tcccaaaaag accaaatcac cacaagcctc ggctggttgc atacacaatc ccatagcaca 180 cctgcttccg gcagtggcgg atatggcagt aatggttggg gatacggtga aagcacatac 240 tacacacttg aaaccgatat aaccatagaa aatacgggtg atgtcaccgc caatattgac 300 aattctctct ttagtgccta ttgggataac gataagcttt ccccttatag ctccggcatt 360 agccctgttc aattaacccc tggcaagaaa atcaccgtgg aacttgcata tgaaattact 420 gcaaatcaat ataacagctg gtactctagg ggtcataata ttacaatact tattcaatat 480 ggcggagact ccttagctta tgtttattct acaactacag atgaaattac tgtagtccaa 540 taa 543 <210> 52 <211> 528 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(528) <223> BLCPAMOF_00916 <400> 52 atgaaaagaa aagtttgttc actgcttctt atggcagtat tggtatgtag tctcctgact 60 gcttgcggcg gctccggagg ttctgtttcg ggtccgaatg gttcttatcc taccggaaat 120 aacgaaatct ccactagatt tgaccaaatg tataccgatt attacagaac aggttcaggt 180 gaccgtgtat ttaccagcag cggttggcat tgggattata cttattacta taagcttcat 240 atcaatatca ctattaagaa tactggtaac actgtggcct atattgatga ttctaatttc 300 atggcatatt gggataaaga cgagctgtca cgctacagca gcatcggcag catcaaactt 360 tctcccggtg agcaaacatc cgttgacctc gtatacaaca tgagtgaatc tcagtataac 420 agttggaata tttccggcca taacgctatt ttaatcatcc aatacggaga tagcgcatta 480 gcttacgttt attctactga aagcagagaa gttacagttg ttcgataa 528 <210> 53 <211> 288 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(288) <223> BLCPAMOF_00918 <400> 53 atgaagatga cctcagaacg aatcaaggca ctgcgagagg cacgcggctg gacacaggca 60 gagcttgctc ggcggctgag tatcacgcgc aatggtgtca actcgtggga acaagggctt 120 tctatgccgt cgcctgcttg tctggttgac ttggcgaagc tgttttctgt ctcaaccgac 180 tatctgttgg gtgtggagcg gttggagacg gtcaatgtca cgggcttgaa tgaggaagat 240 attgcattgt tggcgcagtt ggccgaccgt ctaaggggca atcattga 288 <210> 54 <211> 621 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(621) <223> BLCPAMOF_02133 <400> 54 atggaagatt ctgacgaaag gagcaaaccc atgaaacgga atggactgtt tgtgctcgtc 60 cttgcactgg cggcggtgct gtgtaccggc tgtggcgtaa aggacgagga tttgaaaagc 120 gacccgctgg tcaatgcaga tggcacagca ccggtgggca gtacactggt cgctcctgcg 180 ccgcaggatg atttcgttct gctggacaac aaggatatcc tctctgcaaa cggtctgtat 240 tacgcttcgt gggtcaacgg cgatgcccag ccctacgaaa acagtgaggg caagaccgtg 300 gacctctacg atgcgcagct cacgcttgtc gtgcaggaaa acaaaacgga ggacaaagcc 360 gcctctgcgg tagagggctg gcagacgctg gcacagcaga actacgatat ttccgacaca 420 cagaccctga ctgccgccgg gcaggaatat acggtcattc agttcaccta tcaggatgaa 480 agcaatccgt atgcgaccgg cgttgcggcc ttcgcccagc gcggcaccag tgccatcgag 540 tgggagcttt cctgtcagga cagttattcc ggcgatgcgc tgaaagtcct gaccgatttt 600 ctgaacagct gtacttatta a 621 <210> 55 <211> 699 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(699) <223> BLCPAMOF_02132 <400> 55 atgaccgccc cggaaaaagg ccggtggtac tgggcaaaaa actggctaca ttaccactgg 60 gtctatcttg tcatcgcagc cgtggtgctc tgggttggca tcagctggct ggccaacgcc 120 ctgcattggg gcgagaccct gccggattac cagatcgcct atgtgggcaa aagttctctg 180 ccggaggaca ccgcccacgc cattgaagca gcctttgcgc agtacggcga agatctgaac 240 ggcgacggaa tcgtttcggt caagctcaac cagtatgtca gcgacactga ggacatggaa 300 aacgcttcta cttacgcgct tgcggcgcag atgcagtttc tttccgatat gaacgccgag 360 gaaagctatt ttctgctgct ggatgacccg gcgcattttc aactggacta tcaggcactg 420 gcaaactggg acggcacccc gccgggcgac aacgactata ccgccaccgg aaagaccgtg 480 ccttgggcag actgcccggt gctggccgga tacgaccttg gaacgtatca gaccaccgtg 540 ttgggaacca ccgttactgg cagcagcgca gaactggtaa acggattatt tttaggccgc 600 agggcctttt atgaagagcc cacgaacgaa aaagccgctc atgcccggga aggagcacag 660 cggctatgga agattctgac gaaaggagca aacccatga 699 <210> 56 <211> 1008 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1008) <223> BLCPAMOF_02131 <400> 56 atggcaaaac agaacaccgc ccctactatg aaggatgtgg ccaaggaggc aggcgtgtcc 60 ctcggcaccg tgtccaaggt catcaacggc atcccggtgg gcgaggaata ccgcaaaaag 120 gtggagcagg ccatcaagga actggactac cacctgaacg cctatgcgcg cggcctgaaa 180 agcaaccgca ccaataccat cgccgtcatc ctgcccacca tcgcacatcc ctatttcggc 240 ctgatcgctc attgcatcaa cagctcgctg caaaagcgcg gctaccggat gctgctctgc 300 gataccgact atgacaatga aaaagagcag gaaatgatcc gcatggccga gcagaacaag 360 gtggacggca tcattgccct gacctatgac ccgaagctgg aagtaccctc ggagatcaac 420 tccgtctcca tcgaccggta tctcggcgcc aacatcccct gcgtggcatc cgataactac 480 gcaggcgggc ggctggccgc cgaaaagctg atggaaaacg gctgcaggaa gctcgccttc 540 ctgcgcgtcg gttccagcat cgtgggcgag accaacaaac gcaaggacgg ctttgtggcc 600 gcctgtgaag ccgcaggcgt tccttatgaa ataaagaatc tggaagatgc gcgggacggc 660 atcgtctttg accccatggc cgagttcgcg gtgttcctgg acgatcatct gcaggacggc 720 gtgttggagt ttgacggcat cttctgcgtg accgaccgtc tggcctacca gattgttcag 780 ctgctgcgtc ttatggggct tcgggtgccc gaggacgtgc aggtcatcgg ctttgacggg 840 ctgcgcacct tcggcgacat ggattattac tgttccacca tcgttcaacc cgtggacgcc 900 atcgcagaga cctgcgtgga agtcgtgctg aacgagaacc gcgccaatac cccttccctg 960 ctgtgcctgc cggtcagcta cgcttacggc ggcaccacca aggcatga 1008 <210> 57 <211> 948 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(948) <223> BLCPAMOF_02130 <400> 57 atgacgcaga cctcgccagc tgctgcacgt cagctggacg ctatcccggt ccaccgcaaa 60 agcctcagcc aacggctgcg ggaaaactgg cagctctatg tgatgctgct gatcccggtg 120 gtgctgacca tcgtttataa gtactggccc atgtacggca tccagatcgc cttccgcgat 180 ttcaaggcaa gccgcggcat caccggcagc gagtgggttg gcctgtactg gtttgaacgg 240 ttcttcaccg cacccaactg tgtgcgcatg atcaagaaca ccgtgctgct gagcctgtac 300 agcctgctgt ggagtttccc catccccatc atcctgtccc tgtgcatcaa ccagctgcgc 360 tttgcaaagt tcaagcgggt ggtgcagacg gtgctgtacg caccccactt catttctacc 420 atggtcatct gtggtatgat caagatcttc ctcagtccgt ccggcggtct gctgaacctg 480 atcctgggca ccagcgtgga cttcctctcg gagagcgccg cattccgtac catttatgtg 540 gcctccggca tctggcagga agccggctgg ggcaccatca tttatatggc gtgtctggct 600 gctgtggata ccagcctgta cgaagccgcc aagatcgacg gcgcgtccat gttccagcgc 660 atcctgcaca ttgatattcc ggagctggta cccatgatcg ttttgcagct cattatgagt 720 gtaggcaacc tgatgaacgt gggctttgaa aaggtgctgc tgctgcagac cgagctgaac 780 aaggccacca gcgatatcat tgccgtgtac gtctacgaac agggcatcat caacgccaag 840 tacagctatt ccaccgctgt gggcctgttc aacacggtgg tcaacatcat cctgctcatc 900 atcgtcaacc gcatcgccaa gaaggcggca gacgtcagct ttgtgtaa 948 <210> 58 <211> 435 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(435) <223> ICBIDGAJ_00089 <400> 58 gtgaatcaga actttatgtc cgtggctttc cagaaagtaa atgtccgatg tttccaagga 60 catggtaaca ccatcgtatt cgatcgtgaa atgtttggag ttcagttcct gaaggacggc 120 atccattgcc gcagcgaaca gcgtctgatc caaaggtttg acaaggtagc ggaatgcaat 180 gccatatccc tgcacagcgt actcatgccg cttcgtgaca aataccacca aaggatgctt 240 ctccatctga atcaaagact gcgccagctg aaaaccgttg gatggcatct cgatatcgag 300 aagaagcaga tcaaaggatt tcttctgcat ttgcaattcg ctcagaagtt cgtttccatc 360 catgtaagtt tcaatgtcaa agcagccttg cacatcgtac tgctggacgc tttgaacaat 420 gccatcaagg tctga 435 <210> 59 <211> 888 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(888) <223> ICBIDGAJ_00769 <400> 59 atgaaaaagg aaaagaacgc ggcaaagccg aagacaaagc ggcccgcaaa acctaaaaag 60 gaaccggtct cccagtggat gaccaatccc ctgaacgaac aagttctgga ttaccataac 120 tatgagatga cacagggcga gcaggtattg tattttattc tggcattttt gatcggtggt 180 gtggtgagcc agttcttcta cggcggcctg ttccaggagg acggcgcgcc caccctgctg 240 acctatatca gcaatgcagc ggcatttgtg gtagtcggcc tgattgcagg cagggtattt 300 ctgccggtgc gcagccgcaa gctggcggaa aagcgccgcg atgtgctgcg caaacagttc 360 cgcgatatgc tggagtcgct tacagcttcg ctggcagcta acagcacggt gcgggatgca 420 tttaatactg catacaccga tatgtgtatg cagtattcgg acgatgcact gattgcaaag 480 gaactggatc agttccgccg tgcagagcag atcaatgtga cactggacgt tatgatggac 540 gattttgcca agcgcagcgg catggaagag atcgaagact ttaataatgt attccaggtg 600 tgctacggcc ccggcggcaa catgagccgc gtgatcaacc agacccacga tatcatctgc 660 gagcggatgg aagtggagga cgagatccag gccaagatcc acgcaaatga gaccgaactg 720 aacgtgatca tggtggcgcc tgtgctgatg attgcactga tgcgcagcac gaatgcaaca 780 tttgcacaga atctggcttc accgacgggt gttgcggtcg ttacggtcgg ccttgcaatg 840 tttgtgggcg cgtatatctg gggccagaaa attattgcgg tggggtga 888 <210> 60 <211> 1275 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1275) <223> ICBIDGAJ_00768 <400> 60 atgacgacag aggaattaaa ggcactccga agcagagttc tggacgccat caaccgggag 60 ctgcagccta cccggatgaa cgacgaggaa ctgctgaagg caatcacagc tttggtggaa 120 cgggaaggaa ggggtggata cctgctccca atccagaaga tggataccgt caacggcatt 180 tataaaatgt accgtggtct gggcggcctg ctggattcca ttcttgcaga tgaaaatgtg 240 acagaagtga tgatcaatgg tcccgacaac atctttgtgg agcgcagcgg ccgtctgaca 300 cgggtggaca agcacttcaa ggatgagcag gagctgcgca gggtcatcga cttgatcgtg 360 ggcaaggcgc accgtgaagt gtcggaagca aatcccattg tggatactcg tctggaagac 420 ggcagccgtg tgaatgtggt gctttcaccc attgcattga gcggctctac tattaccatc 480 cgtaaatttt ccaagcagcc tatgactatg agcaagctgc tggaatacgg ttccattacg 540 ccggaagtgg ccaatttctt aaaaaagctt gtggcggcac ggtacaacat tttcattgcg 600 ggaggtaccg gcagcggtaa gactaccttt ttaaatgcgc tttccaatta tatcccgcat 660 gatgagcgta tcatcaccat cgaggattct gctgagctgc agatcactca gattccgaac 720 atcgtgcggc tggagacccg caatgcaacg gcgtcttcgg gcgagagtaa aaaaattgac 780 atccagagtc tgatccgctc cagcctgcgt atgcgtccag accgcatcat cgttggcgag 840 gtacgcggcg cggaagcatt ggatatgctg caggccatga acactggtca cgacggaagc 900 ctttctaccg gacatgccaa ctcggcagag gatatgctca gccgtctaga aaccatggtt 960 ttgcagggcg aggcggcact gccgctgaaa gctatccgtc agcaaatctc cagtgcagtg 1020 gacatcatga tccatctgtc ccgtctgcgc gaccacagcc gtaagacaat gatggtcagc 1080 gagatcttac cgcatctgga cgaaaacggt gacatccgtc tgaatccact gtttgagttc 1140 cgggaggatg aacattctac attgcagcat gtttcgggtg cgttggtgcg tacagaaaac 1200 cccatgatcc agaccgataa atggactcgt gcggggtttt tactggaaga tatccccgct 1260 ccggtgcgga aataa 1275 <210> 61 <211> 1083 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1083) <223> ICBIDGAJ_00767 <400> 61 atgattgttc gagtcggtct gcttgacaaa agtgataatt atatttcaag acttgccaat 60 tatcaaaatg tacattccaa tgaagcggta cagtttgaaa tttatctttt tacggaagaa 120 cagatgctgc gccgacagat gggacgcggc gggcgaatag acgtgttgat tgcggaagaa 180 gaactgctac agtcgccaga agagtacgca cgcagtatgg agcttgcgtt ctggagcgag 240 gataagcacg agcagatgcg cgatggctgt cctgtgatat gccgttacca gaaggccggc 300 gacatctttc ttactattca aggacttgcc tccaaacgcg gcaaaggttc ctcaagctat 360 gcgctgcagg aaaatggaaa aatctgcctg ttccttggcg gtgcgggtgg tgcgggctgt 420 agcacagtag caatgggctg cgctgctgca ctggctgcac aggggcagaa cactatttat 480 ttcagcctga aacagaaaga agaaaacgga caattccggg taagcggcag ttcgctgacc 540 gatgtaatgt atgaaatcgg tatgtggcaa cagctgggcg gcaccgatca ggggcagttg 600 cagatgaagc tgcaaagcat gctccgcaag gacgatgaaa ccggtgtata ttcttttgca 660 ccctttgacc tgccggtgag cgcaatgaac tttggccctg atgatatgca ggcattgctg 720 catgcggtcg gaggtctgtg cgagaggtgt gtggtgtgtg cagatagcta cctttcctca 780 acgttgctgc ggggcatccg ccttgcggac tgggtgatag tagtaagcga cagcaccacg 840 gcaggtaatg aaaaaacaaa gaagttgttg aactcgttgg aagcaatcga cagcatggat 900 gaaaaactga ttgaaggtag cgtggaagtc gtctacaaca agttcggctc ggctggccag 960 aagatggaac tgcccaagta tgcctgtgaa cttggtacga tcccgcgcta tcagaatgcg 1020 gagaaaaaac gcattgttca ggagttacgg gtcagcagtg tctattcaca gctgaacaac 1080 tga 1083 <210> 62 <211> 318 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(318) <223> ICBIDGAJ_01574 <400> 62 atgaagttga aatatgcatt ccaacgtggt gttgcatcag cactgatcgc aggggttgtc 60 cttacggcgg gtctgcccgc actggctgcc agcggcgcag aggctgcgga aaccgaaagt 120 gtggcagtgg ttcaggtggc ttcctcttcg gatgaggggg ctgctcagga cgaatatggt 180 gtggctgcgg cgctcatctc ggaggatgat acgccgctga gcattccgga tgaggagacc 240 ccgccttcgg gcaatgccgg aacgggtttc tggagcgttt tgttccagct gctgaagcat 300 ctggctggga agcactga 318 <210> 63 <211> 546 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(546) <223> ICBIDGAJ_01364 <400> 63 atgggacgtg gcaatgtttg tgtgaccggc tcgtatgagg gcttgttcta catcgacaac 60 gatgatctgc gggtctaccg caggaatgac ccctacgcca aagaggagga aaccagctta 120 cagcgcgacc tcagctgtga agacttttcg agcggtgaat ggcttcttga tgaggtcggg 180 agcagttacg aggaagaaga cgctctcgaa tgcttttgtg ccgaactgcg gaagctctgt 240 cccagcttcc agcctgcggc caactcaaac gtctggctcg gcaatgagcg ccgggtcatc 300 ctcgaaaacg agctgtttta catctgcgtg gaggataacg agtggtcact ggccgtcgag 360 cttgtccaga aagacggcta ttccgactgt gagagcgcat ggatggccgg ccttcagaag 420 cggcgctacc ggggatacct tgatagcatg aaaaaggccc tgctggcccg cctgcccagc 480 attggcgttc gcaccgggcc gtggactcac ggaactatca ccagagagga ggctggcgta 540 tgctga 546 <210> 64 <211> 147 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(147) <223> ICBIDGAJ_01365 <400> 64 atgctgagtg acatgattga tgatctcgtc cgggccgact gcccgcagga aaaggaagca 60 gcttaccggc agctcgaaaa gctcggcgtt gaccgcatta ccgctgatgt catcgccgat 120 gagcgccgaa atgaggcgca cctgtga 147 <210> 65 <211> 351 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(351) <223> ICBIDGAJ_01366 <400> 65 gtgagccgct atattccccc tgaggagatg aatgaagctc agatcaggga gcagttggac 60 gctgagtata agcactggga tgacctgaag aagaacggct gttctgaccc tgcatggccg 120 gatggtgtga atctgaacct tgttcggaac cacatcatct actggtatcg gctcctgcgg 180 gaacgtacca gccagaccgt gcagctctcg atgttcgacg ctggtatgga tttgaggaac 240 gagcggccgt tgccgccgga agtcccggac gggtacatgg ttccgaccgg gaagtacccc 300 gaccgtctga acggaaagtg ggatggcctg atttttgacc cgacaatttg a 351 <210> 66 <211> 405 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(405) <223> ICBIDGAJ_01367 <400> 66 atgaccgatg aaaagaagtt tgaggttcgt gcagagatta cggctcggct gacccagcag 60 gatgttgatg acatcatggt ttctgcgctg gagggcggca tcaactactg gtgcaggcgc 120 gttgttgtgc agggcaagta tcttggggag tacgcaagcg accagatttc tcgcggtggg 180 cagcttgccg tttggctcga agaaccgttt gaggatgaca agacttgtta tatgctcgat 240 ctcgacaagt tcctcgctgg atttaagcag tggctcgaaa attgctacgc caactgcgat 300 gttgtggaca gcacagatgg ttccgttgac tgcggccaga ttgatgccac ctgtgcggac 360 gagattgtcc agcacgcact gtttggcgat ttggtattcg gctga 405 <210> 67 <211> 366 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(366) <223> ICBIDGAJ_01360 <400> 67 atgaagaacg agtacatcgt agcgattgac tacagcgcaa actacaagcc gatgaccatt 60 gattacaaga tgctgaaggc ggagaacctg ctggatgcca tgaacgaggc cgagcagtac 120 atggacaaag aaacggtcta ccttctcaag atcatgaagc gcagcggggc agctcacaaa 180 gtcaagggcg tggatgcacg agaagccacc tacaccgacg ttctcaccaa ccggggcaat 240 ggctggcaca gcaccgatgt agctcactgc gagcagcctt ggatgagcca gatgtggatg 300 tacagcaacg gttttgttga cctctactac tgcgaggaag tccgacctgc ttgtacgaca 360 tcctga 366 <210> 68 <211> 219 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(219) <223> ICBIDGAJ_01362 <400> 68 atgaaaaacg agaacatgac cgctgaggtg acccgtgagt gggagaacga cccgaactgc 60 ttcctgcgga tgctgaacag ccccgcacag cagcggagcc gcgcagcccg ccgccagaag 120 gatgccgacc gggagcactt caacaatgtc ctgaacgccg ttgccatcgg cgcagcagcc 180 ttcgccgtca ccctgctcgt tatctgcttt gttctctga 219 <210> 69 <211> 336 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(336) <223> ICBIDGAJ_01363 <400> 69 atggacaacc agaacatgac ctatcccgaa ctgcgggacc tgttcgttga acacaacaag 60 acccagcttg caaagccggt gagcgcctgc atcgtatttg ctgagagcaa ctggcctgac 120 caccattacc cgctgcgcag ccgcacctat gaggtcagca gcgacaacaa ggctttccgg 180 tcgagctgct gctccaccag cctgttcggt tcctgcttgg atggcaccga ccagatggtt 240 cgcctcgact ggtacatgaa ggacttcggc aacaagggcg gctgggtcgt tgaccactgc 300 tacctgaagg agaacagcga tgaatccgat gtatga 336 <210> 70 <211> 453 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(453) <223> ICBIDGAJ_01074 <400> 70 atgaaatctt tcaaacgatt tttgactcct ctatttattt gtctattcgg ctttttatta 60 ttgaccggtt gtggtagttc aaataatact cctgctcagt cccaaaagga tgccgtgctt 120 gctgcactta atgcagctcg caaatcaaac aatgtaaatg ttctttctga ggacgatcag 180 gcagatatca ttgccgcccg gattgccaac gccggaattg attattactg cggaaatctg 240 acaaaagaac agtttgaaaa agagttttat agtgctggta tgacaaaaat caatggaaaa 300 tacttttccg aaatctatac tggtactatc attccaacaa aatcctctga tttttataat 360 aaagaaatct cttatggtag cgcccagatt gttggtatcg caattagaca gtataaagaa 420 ttcagtttca ccgtccttat ctcttatccg taa 453 <210> 71 <211> 636 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(636) <223> ICBIDGAJ_01368 <400> 71 atgagaacat tgagagagcg cgatgcgctg cttgaagaat tgtggaagcg gttcggggat 60 gtccctatgg acccctccac cgaaacgatg gaggccccgt ttctggattt cccggcagga 120 accagccgcg ttgacatctg gcgctggttt gatgaacggc atagcaaggg cattgcctac 180 ttgctttaca acgaggatgc ctctaacgcg gcaagcatca cgagcctgct gcactgccag 240 aagctctgca cggaatgcga ctccgaaacc tgcgtgttta acccgcaggg catctgcatg 300 gctccgttcc tgaccgggag gaagccgggc gtccacgacg atggctgcac cgattactgc 360 ccgaaaccgc tggatggctg tgagccggtc cgctcctact ccgaatatga gcttcggagc 420 tatgaggagg acgtgcggga atatatctca cagttcaccg atgaggagct tatggaagcc 480 tatgagcttg accgaacgac gctcaatgcg ctcgccccgc gtgcggcggt cttgatgcgg 540 aagtatatcg acaatgacga tagctggacg taccaccgtg attatgccat ctcggaggcc 600 gtcagcgagt ataaggagga caaaaacaat gcctga 636 <210> 72 <211> 309 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(309) <223> ICBIDGAJ_01369 <400> 72 atgcctgaga aaatgatgcc ctatgcgctg cggatgacgc tggcagtgct tgcaaatagg 60 ccggatgatg cccgcaacat ctctgctgag tgcgtcactg cgatgaccaa ggagctgatg 120 ggtgttgcaa gcggttatga tctgatggac ttcccgttca tggttgctgc cctgcggctc 180 accgcgacct cgctggagtc cctgctggac gagcatggca aggggattgc tgacggcatc 240 gtcgccaaca ccacctgcat caccattgat gcttccgagc tgaagcgtca ggctaaagag 300 gaggagtaa 309 <210> 73 <211> 744 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(744) <223> ICBIDGAJ_01073 <400> 73 atgaaaagaa ttatttcatt aggacttgtt ggtatactta tctgttccgc tctcattggt 60 tgtagtgagg gaggtactcc agaagtaccc gctagtactt ctattgcttc ttcttccgca 120 tcatccgaac cttcccctag tcagcctgca tctagtagtt cctctgcacc cgtatccagt 180 tcaagctcat ctagtagtat cccgtctgaa aatccttctt ctagttcaga gagttcttcg 240 gtttctgagc ccccctcttc ttccgaagcc ccttccgaaa gccctgcttc ttctgttact 300 gagaaaaagt ctatctctgt aagctggaat gagaattata tccgctgtaa ggatgttgtc 360 actgacagcg ataagcaggt ctatgttccc ggccaaggct atacatgggg atatcatcac 420 tactatttag atatcatata taatatcacc aatacgggaa attgcccgat ttctcttgga 480 aatgatgctt tttctgttgc atgggatgat gaacctttaa ccgatcattt tgtatatctc 540 aatgcgcaac taattgaccc cgtcaaatta tccgagggtg aatccgcaat ggtcgccgta 600 cgttacccta tcagtgcagc aaaatatgaa gagttttcag acctgtttgc tattgctccg 660 cacaggataa tccatactgt cacatttgaa gaaagcaatt ttacatatac ttatttaaca 720 aagttgtatt cctcgaatat gtaa 744 <210> 74 <211> 225 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(225) <223> ICBIDGAJ_01777 <400> 74 ttgtatatga atttaaaggc agagatggca cgtaacggga ttaccaatga gcagcttgcg 60 aatggaatcg gaatcaatcc ggcaacgatg tcagcgaaat tgaacattgc ggggcgaatg 120 cgcttggatg aagcgcaatg tctccgggat aagttctttc cggagatgac gatggactat 180 ctctttggag atgtccagcc caccgacccg aaaaagagcg catga 225 <210> 75 <211> 219 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(219) <223> ICBIDGAJ_01776 <400> 75 atgaagtatg aagaaattat ggcggccata aaggacatca atggcccgtg gagcaacgcg 60 gcctgcatgg gctactgcct gatcgcaatg cgccgggcgg ggctgaggcc tacagcacag 120 cgccgggtgc tgctggcgct ggaaggggtg ttcgacgatg tgagtgtgga ggaggccgag 180 aaggccgaga aggccggata tgccaataag gaggagtaa 219 <210> 76 <211> 339 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(339) <223> ICBIDGAJ_01775 <400> 76 atgatcgtga tcccggcgaa gaaccgggca ttcaacatga agtgtgatga tggtgacagc 60 atgaagctgg agaccctgca gaagctggtg ggcgggccga tcaagccggt gcccgccttg 120 ctgagcgccg agtgggcgcg ggagaaggac gtggacggca ttctgctgct ggtgaacgag 180 gaagggctga tgaaggagcg ccccctgacg aaccagcgcg ccagtgagat ggcggcggca 240 gagctggtgg gcccggcagt cgtggctgca aagcgcggcg atgagctgat cggctttgca 300 aagcctgtgg tggagaccat ctgcgccgag tggctgtga 339 <210> 77 <211> 267 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(267) <223> ICBIDGAJ_01774 <400> 77 atgaaaaaga agatcacggg cagcgtgctg agcgccggtg ccattgtgct gggactggct 60 gccgtaggct gcggcggggc cattgagaac gcggccaatg gctgggtaat gctgggctac 120 acgctgctgg ccatcgtgct ggggtgtgca gccttggcgc tggccgggct gggcctggtg 180 gcagagcagc ggaaggagcc gcagaagatc cacaaagtgc cggagaacac ggtgaagaag 240 gccgtctgcg gcagaaaggc ggggtaa 267 <210> 78 <211> 294 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(294) <223> ICBIDGAJ_01773 <400> 78 atggtacgga ttgaaattaa aaagacagtc aagggtcaga tgatgctggc ggtggaagct 60 gagcatgaga gcctggacga agttctgaca tgtgctgccc ggtgctttgt gggtgttgca 120 cggaagcttt taggccccat ttctactgac ccgttatttg ccgacgaggc ggcgaaactt 180 attaaggatt tgctgacgga cacggaaggc tttaaggtaa cggaagggta cgagggcaaa 240 gaagcaaaat ttattgccgc gctgaacggt atgaatgcgg gggaacagaa atga 294 <210> 79 <211> 360 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(360) <223> ICBIDGAJ_01772 <400> 79 atgacgctgg aagattacaa gaacatcctg cggacgggaa cgcccagcga ccgggcgcgg 60 gccattgccg aggccgggaa cgacaggagt ctgaccgacg aggagttcca cgagctgacg 120 gccatgatca agggcgttgt gcggcccggg cggcggaaga tgaccccgga cgaggcaaag 180 ctctgggcgg aggtgagccg gatcaacacc cggttgaagg acgagatggt gaacgcgggc 240 tttgcggtga gggccctgcc cggcgacctg caggaggatg caatcaacgt tctttcccgc 300 acggtgagcg ggatgctggg cgacctgacc gccatgatgg cagagaccgg ggaaccctga 360 <210> 80 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_01771 <400> 80 atgaaaacga agatgagcct ttcggcagag atggacctga cccaggacag cgtggtgcag 60 ctgacctgct ggtgcgggca gatcgcctta catgagctgt gggggctggg ccgcacccgg 120 cttgaccgga tcaccagacg gaaggagctg ctgggcagtc tgaagggcac ggaggtgaaa 180 gtgtga 186 <210> 81 <211> 1938 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1938) <223> ICBIDGAJ_01770 <400> 81 gtgaccacct atatctgcaa atgcggacgg cgagtgaaga aatccaccga tgccagtacc 60 actggaaacc gcctatctgg ttacgcaccc ggacatgagt gctggggatg cccctatgcc 120 atgccatacg gagactttca atgggatgaa agtgctagaa ctgtcagccg ggagactcgg 180 ggctacgagt gccggatgag caagaccctc acttatgcgt cagagttcgc tggctctatc 240 aaggataaat gcacctgtcg agtgcatagt ctggacttcg actttctgtc tcaggtctcc 300 gcatggatca aagacactta tccagacaga gagattttcg gctcattttc caaagatatt 360 cgtgcatcgg actatggatc tgacggccgt tactgcctga ctatcacctg cactcagaat 420 ctgaaaggtg ttgccgcaaa aagagagctg tttggtcagt ttttcactcc gaatggcagt 480 cgcaaggaca tgacaccgca gcaggaaatg gaaaagattc ttgccgacat caaaaaagca 540 aaggagattc tctcatgtgc acctgcccag aatgcggatg ctgctgtgac tacggcagag 600 aatgctgtcc cgactgccac agcggcaacg ccgaccatct cggagagcgg ggcggatgca 660 agcgcatcga cccccgcgac atccctgcag aactgcgaat cggcccctgc cgcatcggcg 720 ggcggttctt ctgtatcaac agctggtgcc atgcaggaca agcccttaac caccgtgccg 780 gatgcgatgc gcccggcgtt tgattattcc ggcctgaccg accagaccgt ggaagacttg 840 cattttgcgg agaacgaata ccgccacggt aagcagatgg ccgagcgtgg ccttgtgcac 900 atgggcaatg ccatcgccgc cgcccatgat gcactgtgcg gcaccgttgt ccaacaattg 960 gacaacggcc agttcgcaaa aaaagaggat acgttccggg catggtgctg ctctatcggc 1020 atcaccaagt caaccgccta caacctgctg caggtctctg ccctgatgga cggcagcagc 1080 ccccgccagc gggccattct ggaagcccta ccgcccaccc tgctgtacgc cgtggcaaag 1140 cccagcgccc cggcagagct ggtggagcag gttaagagtg gtgacatcac caccaacaag 1200 cagtatcagg aagcccttgc ccagatcaaa gccgagaaag agcgcgccga tgctgccgag 1260 acccgcgagg aagaggcgtg gagcatggta agtaaggcac aggacgaagc tcagaccgct 1320 aaaagcaatc tggaagttgc ccttgtagac ctgaacggcc tgaccgagca gaacgccaag 1380 ctccagcaga gctaccacga tgcagacgag agccgcattg cggccaacct ccagcgccag 1440 aaggccgaag gtgagcgcga cagggccgaa gagagagcaa aaaatgccga agacgctttg 1500 aaaaagcagc ccatcactgc ggtggtggac aaggaagagg tggagcgtca ggccagaaag 1560 ctttttgccg atatggcaga tgaagaagtg gaccgccggg cacaccagca ggcatacagc 1620 attgcggccg acatgacgga agagctgaag gccgacaagg ccaggctgca gaagaacatg 1680 gacgagctga agcagcagct tgccgaggcg caggctgtgg ttccggctga tctggtcgcc 1740 gataaggaga ccgccgacag ctgttacctg aacattgatg gcatctgggg catggccctg 1800 ccctcgttcc agcggctcgt cggcaccggc gaggacttca accgcgccgc gggcaacctg 1860 ctccagctgt gtgaccacat ccacgaagag ctggtcaaaa tgaccatcgc caacgataag 1920 gagacactgt atgactaa 1938 <210> 82 <211> 1290 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1290) <223> ICBIDGAJ_01779 <400> 82 atgaactggc tatatattac aagcggtgtt gccgttattt ttctcatcat tggctatatc 60 tgtggaaata aagtcggtca taaacaagaa cttgattcta aagaaattaa ttcggcaaga 120 ctcagcagtg aaattcaaca aaaagagcag tccattcagc aacttaacga ttctatcgaa 180 aaatatcaaa aacttgaaag aagtgctgaa aacaatttga gtcttgaaac gcaaaggctt 240 ttaaaagacc gagaagatca gctttctggt cttgtccgag cgcttgactc aagggagaaa 300 aaattagaca gtcgagaaaa ggaactagaa cacgcgaaaa cagagctttg cgatatgctt 360 actactgctc aaataacaac acctttcttg gccaagcaat tttcagattt tatgtatata 420 aatgacttgc ttgatgctga ttacttggaa acgaaatccc gtcctgcttt taccgcagcc 480 gagaaagttc gagagattgc cgctcaaaag cggttgcttc aagaacagtg caaattacag 540 gagtatcagc tgaatctgta tgaaagttct tttccctggc tggcagagtt caaagaaatc 600 agcacagaag atttgcagca actcaaatcc gtagattctg caccggacag tgaatatagt 660 tctttgagaa attggctttc tccgcaggaa tatcagtcct tgtcgtctgt cgaaaggctt 720 caacttgcat tggatagata ttcaaagcgt caaaaatcta attggcaaat tggcattgaa 780 tacgaacgtt atgttggata ttgctatgaa aagaaaggtt atcgtgtacg gtataatgga 840 gccatggaag ggcttgaaga tatgggacgt gatcttattg tttccagaaa taagagtatg 900 ttcgtaattc agtgcaaacg ctgggccgta gagaaaacca ttcacgaaaa gcacattttc 960 cagctatttg gaacaaccat tctccaaaag ctggaacatc ccgactataa tgttggcggt 1020 ttatttgtta ccactacaac attatccgat ttggcaaaat cctgtgcgga atatcttcat 1080 atcactgtta ttgaaagctt tcctctgaaa gcgtaccctc ttattaaatg caatatttcc 1140 aggaatggcg ataaaatcta tcatcttcct ttcgaccagc aatacgatcg cgtaattatt 1200 gatcctgatg atggagattt ttatgcttcc actgttgaag aagctgaaac caaaggtttc 1260 cgccacgctt ggcgatggac tggctcataa 1290 <210> 83 <211> 1224 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1224) <223> ICBIDGAJ_01855 <400> 83 atgaagaata tcctaattgt ggaatataca atttatcttt tttccttcgt tgatgctcgt 60 tttgaaaatc cacttctgag ggaacgtgca gcaatttgga cgggctacgc tttcctcagc 120 ataattcaaa tattatatgg atatgttgtg gaatatgcaa aaaatcgcaa agtaattcgg 180 gatttgtcta tcacaaaata tttgtggttg attttagcgg taatgggtgt gcagctgctt 240 aataactaca cagatgtaaa agagtggata gttatgtttg tgtttttggt tgtggttttt 300 tcgacgggct gtgaatttgc acgttattat gggttgaaag agttattatg gatcaatttt 360 ttgattccca atatagcgac tcttttaaat tatatgataa ataaaattaa tattaatgag 420 aatatagccc agatgaactt ggcagcgttc ttctctagca attactcact gagaactcga 480 ttcaatttag gatttccgaa tcccaataca acgggaagtt tggcagcagg tttggtgatg 540 atagctctcc cactattaac tttcctaaaa acaagggaaa actcagccat aaaaaagatt 600 cttatttaca ttatgatgct gtttgatttc ttgattttag ttgaaagcgg ctcaagaaca 660 gctgtgattg ccgtagcagc tggatattta ttgtatgtat tcttcgtgtt tattaataat 720 ccacgatggt tttccaaaaa aatgcgtcag actcttttat atctgatgtg ttcttttagt 780 tgtgcaggga tgtttttaat tgcaaataaa tttatgacag tttacttgga ttcgggcaga 840 aatcaggcat atcagatttt gacatatttg aaaggaattc gagtatttat cggccttgga 900 atattgaatc caggtgccgt cgataaactt gttatcgatg gacaacctct ctcgggacat 960 ttggataatt actatgttta tcttctaatg acaattggaa tcgtaggttt ggttttgttt 1020 tttgcctttt ttggaaagct ttttcagaaa attcggagga gaacagatga ttcaatgaca 1080 gcagcagtat tgagttgttt tgcgtttaat ttgttgtacg gttttggaga gacaagtgtt 1140 ctctatcatc aatttccaac atcacttata atgtttacga tgtttctgtg cgttgccatg 1200 ggagaaaatc cgaatagaac gtga 1224 <210> 84 <211> 336 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(336) <223> ICBIDGAJ_01388 <400> 84 atgagtacct caaagtgcga gatgtgcgga cgggacatac cgaacgccaa gaaccgccag 60 aagttctgcc ctgactgcgt aaagaaacgt caggccgcac aatcccacaa atcttatctc 120 aagcaccgcg agcattatct ggaacgcagc cttgctcaag ctgaacgtcg gaagcaggaa 180 gcgctggagg aaaggatgct ggaggaactt ttgctcgcaa aaagaccgga accgaagtac 240 agcatcattc aggtggtcga aaaggcaaaa gacctcggca tcagttacgg ctggtgttcg 300 tatctgcttt cggtcggaaa agtctgtatg gaatga 336 <210> 85 <211> 123 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(123) <223> ICBIDGAJ_01386 <400> 85 atgtggactg aaatgtctga tgcagccaag tggctggcag ttggagctgc gattgtcgcg 60 gccattatcg taactgggca gacgtacccg ttgtggttct ttctgattcc gatgatctgt 120 tga 123 <210> 86 <211> 213 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(213) <223> ICBIDGAJ_01385 <400> 86 atgacacgta aagaaatgtt tgacctcaga attgcaagtg atggatttcg ttatgcggtc 60 agaaaagcgc tgtttgaatg ctccaaattt ccgccctgca ccgagcgaat gatcgttgag 120 ggaagactgg ctgaagcgct gtatttttca gagcggatga tggaaaaaac gtacaaagac 180 cttgaaacgg aggaaaaaac taatgtggac tga 213 <210> 87 <211> 348 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(348) <223> ICBIDGAJ_01382 <400> 87 atgcctgaaa tcaagatttt cgatgccctg cctgaagaag aaatcctcgc ccagatggcg 60 gaagaatgcg tagaagcgtc caaggcggct ctgaagctcc gccgggtgcg ctgcggtgtg 120 aatcccacgc cggtgtctga gaaggacgcc ttcgagaatc tggtcgaaga gttggccgac 180 atctaccttt gcagcatcgt cttcttcggc ggcgagctgg atgacaacga cccctgcaat 240 atgtgtgatg cggtcggcga ccggatggtc gagatcatgg agcagaagct cgcccgctgg 300 aagtaccgtt tgatgaagaa ggaggatgtc gatgtccctg aagaataa 348 <210> 88 <211> 261 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(261) <223> ICBIDGAJ_01380 <400> 88 atgaccgaga agtccgaatg gcagttcctc gttgattacg tcaaggatga cacgacagat 60 ttctacaacg atgcctgcca gaaccagctt gtagccttgt ggacctcgta ctgcctgcat 120 aacagcctcg atgtcgatac agcgatgtac gatgcagttt tgatggattt gttcaacgct 180 ctctccgatg aacagaaagc cgaactgcac tgcaccggct tctcggagtt tgatagtatg 240 atggcccagt ggcttgtctg a 261 <210> 89 <211> 360 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(360) <223> ICBIDGAJ_01381 <400> 89 atgagcgaca tacggttagt taatgtagtg cccatcgtca acggatggaa cgatgcggcg 60 aagaagaatc tggaggaggc caaaaccttg atggcctccg ggaaccatct cgactacaac 120 aagggtgttg tcaaggaaag cgttgcgaac ctcgtttccg gatttgccga tgacctgatg 180 aaagctcctg ctgttgaccc ggagagccga cggcctgtat ctcattgggt tttgcaacgc 240 agtgtcgcgt attgcgaaag atgccgcaaa gggtacagaa ttacgaatgg aggagcgaac 300 gtcttgacgt ttagctattg cccgaactgt ggtgcaaaga tggaggataa caatgcctga 360 <210> 90 <211> 648 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(648) <223> ICBIDGAJ_01540 <400> 90 atgggtttga taaccttaaa ccttaaaagg gtattgaact ggaattttat atttatgagt 60 gcggtagcag ctatcttcgg catgatctct ctgatgaact ttggggatat ttcagaaaac 120 attgtatttg gcgttgatat aaagtatttt atgcttgatg gatacctgtg cttatttatc 180 ttttttgccg gagaaataag caaggatatg ttgcagcaag aaaaaatcac aaagagaata 240 gaatggaaac ttgctaatgg tattaaaatc tcaagtattg ttaaggagaa tctgctatca 300 ctatggattg gaacgctgat ccttttgttt cctctacttt tgataatttc cattcgcctg 360 ccaaacctta tcttgttatt aggcacctat tttctgatcc ttagcatatt gtattcggca 420 tttataaatg ttttgattct ctggattaga aatatgaact ggtttaagag tattcctatc 480 tttgcaacac tgcttcatat tttgctggtt gtcttaaaat gtgggatatt tatgaaaacg 540 aataatgtgt gggtgttgct actattttct ccagtgagta taatagtttt gactgcgtgt 600 ggtttatgtc tgatgactaa agaacggatc gtatcatcat attactaa 648 <210> 91 <211> 705 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(705) <223> ICBIDGAJ_01541 <400> 91 atgagtaaca tgggaaaagg cgcaggctac tatcttacca gaagtaaaag cctcctaatt 60 gatactgcga ttgttgccat tctggcgatt tttatgagct ttgcaatgca gatggacacc 120 ttgcagtcta agggagatga ttatttagtc ctaatgctct atgcggttat ttttggtctt 180 acctccctgc aatccggtgc tatgattgta gatttgacag caaaggataa gttaagccgg 240 agaattgaat tttttgcagc ttctggaatt gcagtaaaag agattataaa acagtattcg 300 atacagattt tccgcttttc tggtattatc ccgttctttg tttttatgag ttgctattac 360 tttaccgact ggacaatgag ctttgggcgg atcgtatgcg tttatcttag tattcttgta 420 cttagttttt gtgagattgt cgctttgaat atcattgtac tggatgtgaa acgagtaaaa 480 ctgttcaaaa atgttctgtt ctttggtaat tttgcactgg tttatttgat tgcgatgtcg 540 gcagaacaga ttacagagtt tgtgaatcaa catcatatag gaattgacta tttgattatt 600 gtggttgatg ttgcactttg catgatgttt gtactattaa gtttctttaa ggctcggcac 660 atgagcaacg aaacagttat caggagggat ggcgaatggg tttga 705 <210> 92 <211> 513 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(513) <223> ICBIDGAJ_01780 <400> 92 atgtttacga gcaaacaaaa tgaaccagat tatacgcctc cggaaattga accaggggac 60 attaacagtt atattacaaa ccgtctggat gatcagatca actggtacga taaaaaatct 120 cagaatgcac aaaagcgcta taagtgcttg caactgaccg agcttgttat tgccgcagcg 180 attccgctgc tttccagtta tactgttgga tgttcccaag ttgctttcat ggtaggtgtg 240 ctaggtgctg caatcgccat catcgaggga atcgagcgtc tttatcgcta ccatgaaaac 300 tggatcgaat atcgtgccgc ttgtgaggcc ttgaagcacg aaaaaagcct ctatctgatg 360 aatgcttttc cttacggaac ggatgaaaca aaagagcagt tgttcgttca caacatcgaa 420 aatttgcttt cctctgaagg cagcaaatgg aaatcttcca atgcaaagcc tgtcacagat 480 aagagcaaaa ctcagtcggg aaccgcttcg taa 513 <210> 93 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_01781 <400> 93 atgaaatttc aaaaaaaacc ggtcattatt gatgcgtacc agactgacaa agatgtgtat 60 attgagacgc tggagggtgt gatgcatgcc tcaccggggg attggatcat taccggagtc 120 aacggagaaa agtatccctg caaaccggac atttttgaaa agacttacga agcggttccc 180 gactga 186 <210> 94 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_01373 <400> 94 atggctcgca aggaaatgta cactctcaag gttgacggcc gggtggtctg gaccagcaac 60 cggctcccgt acatgaagaa gatcgcaaac gaaacgcttg agctggacaa cggcttcttc 120 gctgagattc tgcgctacaa caagacatat tcgacccgct tctacaacac gaagtggaac 180 cgctga 186 <210> 95 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_01372 <400> 95 atgaaaacct acatcgtcac ctatttccgc cacaaccctc agctcaagaa cggaggctac 60 acctccacct gcaaaattga ggccgcgtcc atcgcgtcgg cccgcaagaa ggctcgcgag 120 ttctgcgaag gcgcggttta cggtagccgg gagctgctgg atgttcagaa ggaggtcaac 180 ggctga 186 <210> 96 <211> 444 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(444) <223> ICBIDGAJ_01371 <400> 96 atggtacgcg cagcccttgc tggagcaggg aagacccaga aagagttggc cgaacacatg 60 ggctggaccc cgcagaacct cagcgggcgg ctgaagaaca actcgctcac cttcgatgag 120 ctgtcaaagg ctctgcattt tgctggttat gaggtctcca tgagtgatgc caacggtgcg 180 ggcctcccgg agctgggcaa cagcaccagc cccgccgtag cgcagaccgt agacggcgtt 240 cgatatgaca cccgcaaggc cgaatcgctc tgctcgaata aggccgcgat gttcgaggac 300 ttctatgtgg agctgttcga ggatgccgct gggaactact tcaccgtcct ctaccagctt 360 tctggatgcc agcatcatac catcaccccg gtaagcgccc gtgctgccca gcagttctta 420 gagaggttcg ggagcagagc ataa 444 <210> 97 <211> 519 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(519) <223> ICBIDGAJ_01370 <400> 97 atggaaatca agcgcggcga catttggtat gtgagcaagg acaactacac cggctgtgag 60 caggcggcgg gacgcccggc aatcatcgtt tccaacgaga agaacaacgc ctgtgcagag 120 acggtagagg tcgtatacct gaccacccaa ccgaagaaag acctgccgac gcacgttctc 180 atccgcagct ctgaacgtga aagcactgcc ctctgtgagc agattacgac cgtatcggtt 240 gaccgcctgc tgggctacaa gggccacctg accccggcag agatgaccaa cgtggaggtt 300 gcaatgctga tctcgctgga gctggaagtt ggaaagcccg tagagaaaat cgtggaggtc 360 acgaaagaag ttccggtcgt ccgggatgtc aaggtatcta cgcctgcgtc aaatccgaac 420 atggctgcgg agctggccgc agcgaaagcc aagtgtgaaa tgctccagac catgtacgag 480 agcctgctga atcgggttct ggctggaaag gcaggctga 519 <210> 98 <211> 735 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(735) <223> ICBIDGAJ_01377 <400> 98 atgaaaaagg tcgttagtcc gtgtttctgc aaggtctaca cccgaagcgg caatgaagcg 60 actgcgcggg cattctgcga aatccagttt gagaatggca gactcagtat caccggcgtt 120 atcggccctc tgcgcagcgg tggccatcgt ggctgcgctg gtcagtgcgt tgatgaaatc 180 cgcgaaggct gcccctgcga tgaatggacg caggaaatgc tcgacaagtt ctgctccatc 240 tgggacgagt ggcatttgaa cgatatgcgt ccgtactgca agcaccagaa ggagcttgga 300 tgggacaagc tggccgtcac gcctgtcacc ctgtaccact atcggctgaa cagcaaaacc 360 ctccggcggc aggaatccat gaagaaaagc tcatggaaga tgctctgcga tggcatgacc 420 gctgctctga gcgatgacca gattgaagtt gccaaattgc cgtacagact tacgctccct 480 cacgaaatct ctggcgaggc ggctttgtat tacgagccgc agaagccgct ctaccccgga 540 atggctggtg cgaccgaaac gaagaccctc ggatggctcc atcccgatga acaccccgat 600 ggcattctcg gcaagccctg cccgatttgt ggctaccagt acggccacgc atggcagacc 660 gaagaagtcc cgcaggaggt tatcgactgg ctgttcaacc tgcctgaatc gcccgtcgaa 720 ccggagtggg tgtga 735 <210> 99 <211> 234 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(234) <223> ICBIDGAJ_01376 <400> 99 atggaaagga actggttgct cggtgatgac ctcgccgcct gcgacaacct gcttgacggc 60 atcacgttcg atgacatcat cacgcaggtg cattgcaact gccgcaacat cacgcccgat 120 gctgttcgca aggaagtcga tgacctctta aaactgcggc tcgccgatat gcgggagctg 180 cttgagcgaa acatcgacaa gattgccgaa gaagcacgaa aggggagaga gtga 234 <210> 100 <211> 279 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(279) <223> ICBIDGAJ_01375 <400> 100 atggcaaaga tcatgttggt catgacccat gaggaggtcg atacgaacat cgcgtacagc 60 ctcatctgct tttctcgtta cggcagcgca tgggacaccg gtcgccgccg tcgggcgtgg 120 ttggcaaact tcaccgagga ggagcgccgt gcggcctgtc ggctgttcaa acaggcgcgt 180 ggctggaccg ttggccgagg cgttcccgat aaggtcacga tgaccgagaa gacattctgc 240 ctgtggcgca agctcgctga gttttgcgct tctatctga 279 <210> 101 <211> 162 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(162) <223> ICBIDGAJ_01374 <400> 101 atggcattgt acgccgttta ctatcagacc ggtgtttcgc cccttgatgg cgcaccgctc 60 tgcaccatcg accttgtgac gcaggtcgag gccaccgcga ttgccaagca gcaggagctg 120 accgatgccg gtctggttgc ttggcatgag cagattcagt aa 162 <210> 102 <211> 660 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(660) <223> ICBIDGAJ_01379 <400> 102 atgatggaca aaatcgtggt cacagcggcg gacatcgaaa agctccttgc atggcgggat 60 gagcacaacg atctggttcg ttcgatgccg gtttccctgc gagaagtgga aatccagatt 120 gtcgagagtg gcatctccat caagtgcttc cgctctgaca agaagctgaa gctctacatc 180 gacagcccgg cccggaagct cggccacgtt gtctttgctc cgctgggcaa cggcctgtgg 240 aagaagaagg taagcacgct tcctgcggac tgcaacccca ccgaaaccga acagggcgct 300 ttgactgtgt atggctccct gatggcgctg atgacgtatg gaacgggtag catccgtggt 360 ggcatggcta ccacaacctc gaaggctcct gctggacgca aaagccctac aaagccgcac 420 accgccagca ccacatacat cattcactcg gtcggaaaac agcttacagt ggttcccaga 480 ggccaccatg caagcccggc ctgttccttt accgtaagag gccactttcg ccactacaaa 540 agcggcaaga cggtctggat tgcggagtac cgcaagggga ctggccgcag ccggggcaag 600 acctacaaga tcggaggtga tctggatgac cgagaagtcc gaatggcagt tcctcgttga 660 <210> 103 <211> 1194 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1194) <223> ICBIDGAJ_00164 <400> 103 atgaatttgc cgttggtatt ggaaaagaat acaactccgc agaattggaa tacacggcgg 60 gaagtgctgc tcgcgttgtt ccgctcgcag gagtacggca tccggccgga agttccctat 120 gaacagaccg aacacctgcg gtcagaagag tatctgccaa aatgcaaggc catccggcag 180 atctgggatg tctgtctgaa aacgaagctg ggaatcctgg aattccccgt ggtgctggtg 240 cgcccggagg gaacacagaa gatcccggca gtcctgttcc tttgcaatca cgaaaaaact 300 gcctctcccg ggccgaaaat ggggcctgac cagatggaaa aactgctgac caatgccccg 360 gaagcgtggc gcagggaggc catgaatttc ttccggaata tgccagccga aagcggcggg 420 ccgtcgctca ttgatatcga acaggaaacg gagcaggaat actggcctgc tgaacagatc 480 gtacaatcgg gccgggcagc cgtgaccttc tatgcaagtg cattgcagcc cgacgatgct 540 gcgcagtatc ccggcccact ggcaaagctt tttgggctca gtgcagatgc actgcctgcc 600 gatgcatggg gaaccctgga catctgggcc tttgggatga gctgtgtggt agacctgctg 660 gtaaaacacc cgggcatcga cccggcccga atctcggtgg gtggtttctc gcgcggcggc 720 aaggcggcgc tttggtgtgc ggcacaggat gaaagggtct gcggggtcct cgtcaatgat 780 tccggctgct ctggtgctgc cgtgtcccgt ggcaagcatg gtgagacggt gggttccatc 840 acggcagcat ttccccattg gttctgcaaa aattatcaga agtatgcatg gaaagaggag 900 acccttccct tcgatcagca ccagctggtg gcctgtgtgg caccacggct gtgttacata 960 accagcggct ctgaggatcg gtggagcgac cctgatgcag agtggaatgg tgcaaaaagc 1020 gccagttgtg cctgggagct cttcggggac gctcctctgc ccagccagcc gcctgccaat 1080 gactcgggat acctgactgg gcgaattgga taccaccgcc gcaccggcgg ccacgatatt 1140 acccgatggg attgggcaat gtttctgcgt tttttggatt ttcacaatgg ctga 1194 <210> 104 <211> 252 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(252) <223> ICBIDGAJ_00399 <400> 104 atgatgctcg atttttttct actggacatg agtatatgct tgtttatgca aagtcagtgg 60 ccagtctttt gggaaataat gtatatttca gagaagaaaa accgggagca gctgaaatat 120 acgctgaata ccttaggctt caacaactat atggaactga ttgcgcaaag attcaagatg 180 gcttgcaaga tttttattca caccttccga aagatcatcc ggcaaaaaag ctttcacgct 240 ataataaagt ag 252 <210> 105 <211> 1785 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1785) <223> ICBIDGAJ_02460 <400> 105 atgggcttac tcggatctct tttttcggca gccgccgata tcgcaaagga aactatcaca 60 gaaacaatga atcaaaatga aaccgaaaaa ttcattaaga taatgatgga gcgcgatgct 120 caaaacgctg aagcaaatga aaaactctat caagactggc tcacgcatga aagaagcaac 180 tattttgcgg ctaaaaagaa tactatcatt catgatgcct ttgatgttct gatggattct 240 tttgaggata ccggaaaatt tgatttttct gctgtggata gtttgagcga tgaactgaag 300 aacagcgata gctataagca ggaggcagct gatgttgtta atctatgctg cgaagctcta 360 gttaaactgc atcaaaagtg ttgtatttcc attcgatttg ttatgcagac aattcacaat 420 ttacagcgct tcgccgatat tgtccctagc attcgaggct tggatcgtca ttatgatgct 480 ttcttccctg ttgacaatgc cgattgcagt tttttgacag atttcgacag cattgcggaa 540 ggattagaag ctgccaaaaa tgattctgat aattatctcg cgatggttgg aagcaacagt 600 ccgttgtcaa ggcttgcagc tttgaaagat attttgaaat cggaagacta tgttgctgct 660 gtttccaatt tactttttgc cgatcaagag gttgctcctt atgcaggtat gaaaaaaatg 720 attctctgtc tctctatgga ggaaacagac gaagctaccg ctcttctttt ggatacatat 780 tgtacggtta ttatgaatta tttacggctt tcaacagcta aagaaaaagt cggaaaagat 840 aatcctttta tttctgcatc aacagagcaa atcctgccaa tcgatctttt gattgctcaa 900 tctattaaat cttcgaaatc tggtagcccg caggaagttg ataccaatct cgatgagttc 960 cttgaatatt atcctctgat ttgtacatct agctgggaag atcagctttt catacttcag 1020 aaagtttttg cttacctcaa aatgtattct caggagagaa aggttcttga atttttagtc 1080 aaaaacaata ttcctcgtac tgagcaaatt gatcgtcggt taaacttttt gaaaaatctt 1140 aatcaaaatg acattagtaa tgcggccaac agcatagagg aatttagcat tcagacaagt 1200 gataatgaaa ttgcatatga ttatcgattt atttcttgga cagtttcgga aataaactcc 1260 tatatgaacc ttttaactag cgaggacaaa acactcgatc ttcctatggt tgttgctgaa 1320 tggaacaaga aaattcctca aaaaaatatt cgctggagta cagatgctat gcaagtttac 1380 cttgataagt atctccatga aaattttggt gatctgtata caaccaaaat taaaaactgc 1440 ggtgcagtac tctcaaatga agtagagtac gagccttccg tctatattga agcaaccgac 1500 agcgctaaat atccgtggct ttcgtttgtt gttactggtg aacagcttac catgacacaa 1560 gtttccttcg ctatttatgc gttgtatctg cctacgaaag actcccaatg cactcaggcg 1620 gttgatacaa tcgaacagaa tcagaaatac caaaatcgac tgattacttt aaaacaagct 1680 cagaatccta aaatcaagaa ttatattgag tccatcaatg aaattctgat ttctggtctt 1740 gaagcatggc taaataacaa caatacttct agcatgtatg attaa 1785 <210> 106 <211> 369 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(369) <223> ICBIDGAJ_01660 <400> 106 atggaaaagg gtacggagac ggtcatcggc agcggcggca cccgcctttc cggcgggcag 60 gcacagcgtc tggcactggc ccggacgctg gcccatcccc gcccggtgct ggtgctggat 120 gacccattct cggcactgga ccgcagcacc gaggatgcga tctttgccga gctgcaggcg 180 tatgccaggg ataaggtggt gctcctgatc tcccaccggc tgtaccattt tccgcagatg 240 cagcagatca tctttatgga gggcggcagg accaccgttg gcacccacga ggcgctgatg 300 gcagcggttc cggtctaccg ccagctgtat gaaagccaga ccggcctgaa agggggagag 360 ggcgcatga 369 <210> 107 <211> 1452 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1452) <223> ICBIDGAJ_01847 <400> 107 atgaaaaagc agaatggaaa attatcaaga gacgaatttg tatcgtttgc taaagcggtc 60 ctgaggaaaa attcattgga agaaaacaag cctctctatt ttgagtacag agtatccgga 120 aacagcaagc ttgcagaatc tgcaagaaga tttgatgcat ttgcgccaga tggatttttt 180 aaatatcaag ggcctgtgat tttcgaattt atagatagca aatcaaaaca gctggaaaaa 240 cgaatcagag cagtggcgga tgattataga aagaattatg acgcggcaac tatcttcatt 300 gtaaatgcta aaatatctct tgaagaatta gaccttacag tatgggatat cgatgagata 360 aacaaatgga tcaaagagta tccagctgag tatggtcatg cgtgttcatg gaatattgac 420 cgtaaaagaa ctacacaaaa caaagaaaag tttcaaatct ccgataatct gtacagagat 480 gacttatatc aaaaaaacaa tgatatttat acaaatgcaa tacgtatctg catcgaagag 540 aaaaagggcg ttgcaattgt gctgggtgcg ggtgtttcga aggagcaggg agcaaaaact 600 tgggatgaat tgctgagaga ttttcagaaa gagatcgagg agcagcatct tttggatgat 660 tccgaggcgg tttttcagga agttggaggg acaagtctta caacagctca gttatgcaaa 720 gacgtctggg cagatgagaa aacctttgct tggcaagtcc ataaaagtct atatgataag 780 gcgcgggaac tggatgtgaa taccgagtta ggggagattg cgcaactggc tcaaaaatgc 840 ctaaaagatc aaaactttag gattttaacc tataattacg atgacttcct tgaacagtat 900 ttagagtggt gtggagtaaa gtgttgttcc atgttcacaa cgaaggttag atactcaaat 960 ggtcaggtga gtgcggattt ttatggcgtg aatggacaac caaatcaaag cttacgactc 1020 tatcatgtgc acggattttt accaaaagtt gcaatgaaaa gtcaactgga tacacttcac 1080 ataagatcaa tctgcctgac ggaagctgac tataatatgc tttataatca accttatagt 1140 tggccgattg caagccagct ttctttcttc agagaaaata tttgtttgtt tattggatgc 1200 agtttaagtg atcccaatat ccgaaggcta ctggaaatca cagcgtataa tccgcctaag 1260 cattatgcta ttttacctac gatgtataaa agtagcgatg catctggtgt tgcgatgaca 1320 aaacagttca caacaagaga ccgacttcaa attgaaaatc atttttatcg cattggaatt 1380 aacattctgt gggtaagaga ttacagtgcg atacctgtat ggttgcacga tttgaatcaa 1440 tctattattt aa 1452 <210> 108 <211> 156 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(156) <223> ICBIDGAJ_01396 <400> 108 atgtccaaga cgaagactga aacctatgtt ttgcgcaatt ctgctgatat cccctgggag 60 gggaagagaa caaagctctt tacgaacgcc tcaagaaaga gatcgcagac ggccacccgg 120 tggatgaata caacaacgaa gtgctctgcc gcctga 156 <210> 109 <211> 3393 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(3393) <223> ICBIDGAJ_01556 <400> 109 atgagcgaca attacaccaa agtgcagcag gcgttccgca tcctgcaccc gcagctggca 60 gggtatgtct gccaggagct gcgccgggaa tatcaggaca actggtggca ggaagtcctg 120 atgaccctct ccgaccagac ccgcgacctg ccggacgaca acggcgatta cgctaccctg 180 atggattctc tggacattgc caactgcctg cgtctgttcg accgcaagtg gaacgacctg 240 ttcaagcgca aactgtccat cgactaccgc acctgggcca aggagctgat gggcgtgcgc 300 aacaagctgg cgcacatcgg cggtgcggat ttctcggagg acgatacatg gcgtgcgctg 360 gacactatgg cgcgcctgtg cgaagccttt gacgacgaag ctgccgagga gatccgcaaa 420 atgctgcgcc agctccgcta tggcagtgcc gaaggctcca ccaatgtcac cgaagtaacc 480 gccccggcaa agaccaaagc agcgcacacc gtcggcatta tgagcaaaac actttccggt 540 ctgcccagct ggcgggatgt catcgaaccg cacccggatg tggcgcaggg acgctataaa 600 aacgcagagt tcgctgctga tcttgcgcag gtggcacgtg gtgagggcgc gtttgaatac 660 cgtgacccgg tggagttttt tgcccgcacc tacgtcactg agggtatgac tggcctgttg 720 gtgcaggcac tcaaacgtgt ctccggcaag gatggcgaac ccgtcatcca gctaaaaacc 780 gcgtttggcg gcggcaagac ccacagcatg ctggcgcttt accacatcat gcgcggcagg 840 gtatcggcag accgcatccc cagcatcaag cccgttttgg cacaggcagg cgtttcggct 900 ctgcccaaag ccaacgtggc ggtgctggtg ggcacggcac tggaccccac ccgaaccaaa 960 cggcccatca atttccccgg catcaccatc aacactcttt ggggcgaaat ggcagcgcag 1020 ctggcggaat cggctggccg tccggaactg tacgattttg tcaaggatgc agataaaaag 1080 ggcgtttctc ccggcagtga agcgttgaaa aacctgtttg atgcctgcgg cccctgcctg 1140 atcctgatgg acgagcttgt ggcgtatgcc cgaaaattgt atggtgtgtc cggtctgccc 1200 gccgggtcgt tcgataactt caactctttc attcaggaga tcaccgaagc cgcacgcgcc 1260 agcaagaaca gtctggtggt ggcttctatc ccggaatcga atatcgagat cggcggcgaa 1320 gcaggaaaga acgcactgga aaccattgaa catacctttg gtcgtatgga atctatctgg 1380 aagccggttg ccgccaacga gggctttgag gtggtgcgcc gccgcctgtt cctcgactgc 1440 aaggatccgg aagcccgcga ccgcgtgtgc acggcattca gccagatgta ccagaacaac 1500 cccggtgatt ttccggcaga caccaaagaa gtggactacc gtgatcggat gatttcctgc 1560 tatcccatcc acccggaaat cttcgaccgc ctgtacgatg actggtccac gttggaacga 1620 ttccagcgta cccgcggcgt gctgcgcctg atggcggcgg tcattcatga gctgtggatg 1680 ggcagcgatg ccagcgccat gatcctgccc ggctccatct cgctggacgc acccaacgtc 1740 cgcgatgaac tgatccgcta tctgccggaa ggctggaact ccatcgtcaa cacagagatc 1800 gacggcaaaa actcggtgcc ttaccagaaa gaccagagca accagcggta tggtcgcatc 1860 atggcttccc gccgggtggc gcgcaccatc atgctgggca gtgcgcccac agtgcgttcc 1920 cagtccgtgc gcggcatcga ggcttcccgc atccgtctgg gcgtggtcca gccgggcgaa 1980 aacatcgcag acttcaacga tgccctcaac accctgcgcg gctcgctggc gtatctgtac 2040 accaacacca gcggcgaccg ctactggttc gacacccgtc ccaccctgcg caaaaccgcg 2100 caggaccgtg caacacaggt ggcggaagcc gacgtggaag aagaaattga aacccgcctg 2160 aaaaagctgc gcaaggaaga gccgtttgcg ggattgcacg tctgcccggc ttcctcgctg 2220 gatgtgtcgg acgatcaggc ggtgcggctg gtcattctcc gcccggatga gacctaccgt 2280 gccaatgcgt ccagtgccct ggcactcact gcggcagaaa atatcctgaa cacccgcggc 2340 acagcacccc gcatctaccg caatatgttg gcgttcgtgg caccggatca ggaagcagtg 2400 atctcgctga agcaggcggt gcgggacttc cgtgcgtggc gctcaattca ggacgacaag 2460 gaaacactga accttgatgt cacccagaac cgggaagtgg atgccaacct ccaccgcagc 2520 aacgataccg tggaagcccg catccgggaa acctactgct ggctgctcac cccggagatt 2580 gaccgcttcg tggatatgaa aaccattctg tgggatgcta cccgcatttc cggcggaacg 2640 gacagcatcg tgtcccgtgc ctcccgcaag atgcagcaga gcgaaacgct catcaccaag 2700 tgggcacctg ccctgctgca aatggaactg gacgaagtgc tgtggaagga tgctgaccat 2760 atccagatca agaagctgtg ggagtacctc tgcacttact gctacctgcc gcgccttgcc 2820 aagttcagcg tgctggaaga tgccatccgt accggcctga actcgcagga atattttgcc 2880 cttgcggccg gttacacggg cgaccgctat gttgaactgc ggtataacca gtttgtggac 2940 tgcatcaaca cctccgacct tttggtcaag ctggaccctg cccgcaagca gcttttggct 3000 gaaaaaagtg ctcccgcagt agttgtgcag cctacgcaaa ctgctcaggg cggcgaacag 3060 cccacccttt tcaaccttcc cccggatgct cccattgacc ccactgtaac cttgcatcag 3120 ccgccgacag cgcaacctgc cgctgttccc gctccgccca aaaacacccg gttctacatg 3180 actgccgagt tggacaccac ccgcatcaac cgtgatgtgc agcggctggt ggaggaagtc 3240 attacacacc tgctcagcgc agatggctgc aaagtttcgg taacgctgga tgttaccgcc 3300 gatgcaccgg acggtctgtc cacccccatt gtgcgcaccg tgatggagaa ctgtaaaacg 3360 ctgaaggtaa aagattttgg cgtagatgaa taa 3393 <210> 110 <211> 2781 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2781) <223> ICBIDGAJ_01555 <400> 110 atgtctaaaa agctgattga agttaccctt ccgctggaag tgatcaatgc ggaagcagcg 60 cgcgaaaaat ccatccgtca tgggcacccg tccaccctgc acctgtggtg ggcacggcgt 120 ccgctggcgg cggcacgcgc tgtgatatgg tccagccttg tggacgaccc ctctgcccac 180 ccggaactgt accccaccga ggagacccag aacgccgagc gtcaaaggct gtttaccatt 240 ctggaaaagc tggtcaagtg ggaaaactcc aacgacccgg aggtgctgga cgccgccaaa 300 gcggagatcc tgcgctctac caataacaac ccgccggcct tgctggatcc ctttgcgggc 360 ggcggtgcca tcccgctgga agcccagcgg ctggggctgg aagcccacgc ccacgacctg 420 aacccggtgg cggtgatgat caacaaggcc atgatcgaga tcccgccccg gtttgccgga 480 cagccgccgg tcaacccgga cagccgcgcc aagctggatg ccgccggggg ctggcaggga 540 gcgcaggggc ttgccgccga cgtgcagtat tacggcgagt ggatgaagcg ggaagcgttc 600 cgccgcatcg ggcacctgta ccccaaggta aaagtacccc atgaacttgg cggcggcgag 660 gccaccgtca ttgcgtggat ctgggcacgc accgtcaaat gccccaaccc cgcctgtggc 720 tgtgagatgc cgctggcgag tacatttgtg ttgtccaaaa agaagggcaa tgaagcattt 780 gttgaacctc aatttgacta tgcaaccaag aaaatcactt atacggtgca caaaggaaaa 840 ggcaaagttc cggaagcacc taagactgca cgcggcgcaa aattcaaatg tatcatgtgc 900 ggtgaagtga cgccggaaaa ctatgtcaaa caggagtcca tgcaaggacg aatgggttct 960 gcactgatgg cagtggttgc agagggaaga aatggtcggc tgtatctttc gccagatgag 1020 acgcagtggc ttgtagcgga ttgtccaaag ccgaatgcag aatatcctga ccagtcgctt 1080 ccttatgacc cgcgaaatat atggtgtgtt aattatggtt tggatactta tgataaacta 1140 tttaccaacc gccagctgac tgccctgact actttcagtg cactggtagc agaatcacag 1200 gcaaaagcgg aagcagacgc ggtggccgcg ggcgttacaa acgaccatat tgccttgagt 1260 gcaggcggct ttggtgcacg ggcttatggt gaagcggtgg gcgtatatct tagctttgtt 1320 atcagcaaac tggcagaccg tggaagttca atttgtagtt gggattcttc tcgcgaaggt 1380 ctgcgaaata cgtttggtcg tcaggcaatt cccatggtat gggactatgc ggaagcaaat 1440 ccattcagca attcttctgg ttgctttgat aatatgctgg actgggtaac aaagtgtatt 1500 gtagaatttc cggctcagag tttcggtgag gttagtcagt ttgatgcaca aagtgactgc 1560 ggcttgcgga atattatggt gtcctccgat cctccctatt atgacaacat cggctatgca 1620 gacttgtccg atttcttcta cgtctggatg cggcagtccc tcaaagaaac ttaccccaaa 1680 ctgttccgta ccatgctggt gcccaaggcg gaagaactgg tggcaacgcc ctaccgcttt 1740 gagggcagta ccgaaaaagc aagggacttc tttgaggatg gtatgctgca cacctgccag 1800 caaatctatc agtatgcccg cgaggatgtg ccggtgacca tctactatgc ctataaacag 1860 agtgacacgg acgaaagaga agctgaaaaa cagaccgctt ccaccggctg ggaaaccatg 1920 ctcagcgcta tcatcaaggc aggctttgcc attactggca catggcccat gcgcaccgaa 1980 atggcaaacc gctccattgc gtccggcacc aatgcgcttg cgtcctccat tgtgctggtg 2040 tgccgcaagc gcccggcgga tgcccctcag gctacccgcc gcagcctgat tgcggaactg 2100 aagcgggaac tgcgtccggc tttgaagaaa ttgcaggaaa gcaacattgc gcctgtggac 2160 ttggcgcagt ctgccattgg ccccggcatg ggcgtgtact cccgctatgc ccgcgtgctg 2220 gaagcagacg gtacccccat gaccgtgcgc agtgcgctgc agatcatcaa tcaggagctg 2280 gatgtgtact ttaacgagca ggacggcgag ctggatgcca acagccgttt ttgtgtagat 2340 ctgtacactc agaacgcctt taacaacatc cgctttggcg atgcagatac gctggcacgc 2400 gccaaaaaca cctcggtggc agcactggcg gcaaaaggcg tgctgagcgc cgaaaagggc 2460 atcgtccgcc tgctcacccg cgaggaactg ccgcaaaaga ccgacccccg cgaagaaatg 2520 atctggctgc tctgccagca gctcacccac gccatggaga ccgacggcgt ggaagcctgt 2580 gcgcagatcg ttgccccgat actggggtcc aacgccgagc gtgccaaaga ccttgcctac 2640 cggctgtaca ccctcgccga gcgcaagggt tgggcgcagg agggctacgc ctacaatgcc 2700 ctcgtggtgg catggcggga aattcagtcc cgtgcggcag aactccagca ggcaacaccg 2760 gagcagacct cgttcttcta a 2781 <210> 111 <211> 1263 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1263) <223> ICBIDGAJ_01554 <400> 111 atggaataca ctgtggatga agtttatggt ctttctagaa acattccgct aaattatgta 60 gaacgtcatg acgttgatga acgccttcgt tgcaacctaa atagagacaa acatatcact 120 atctttggaa gttcaaagca aggtaaaacc tgtttgcgaa agcattgcct aaatgagaac 180 gactatattt tggtgcagtg cagcaatcga tggtcattat cggatttgaa tgccaacatc 240 ttaaagcgtg ccggatatga gttaactgaa tccaccaatg taacctatga aggcaaagcc 300 aaggttagtg cgtctgttaa gattttagat gcaactcttg gtggcgaggc cggtggtgga 360 gcaacaaaaa atgtcacgca tcgtcagttg gaactggact tgtcagatgt aaatgatatt 420 attggtgctt tgaacgaagc ccgctttcat caatatattg tactcgaaga ttttcattat 480 cttaaaagcg aagtacaaaa agattttgcg attgaattaa aagccttcca tgagagttcc 540 gagctgtgtt ttataatcgt tggtgtttgg ttggatgaaa acaaactcgt tatttataac 600 ggcgatttaa ccggacgaat tgttcccgtt aatgccgatt tatggaatga agatgagctt 660 cgagaagtga ttcaaaaggg agaagacttt ttaaacattc gtttcaaaga gtcttttaca 720 agtgaagcca ttaaagcaag ttccggaaat gtttatatcg tccaagaaac ttgtcaccgt 780 gcctgtaatg agtctggaat tcacaaaacc gttgtgggtg aacggcggct tgttggtgat 840 ggactaaatg ccagaagtct cgttgctgaa attattcagg agcaatctgg aagatataat 900 gccttcatta caaattatgc aagtggtttt caggaaaccg cacttgctat gcacaaatgg 960 ttgctatacc ccattctaac atcaagcatt gaggaacttt ccaaaggtct tacttacaga 1020 agtattcgat caaagatcac gagtggacat ccacaaggca aaaatcttaa tccggggaat 1080 attacgcagg cattaaaagc agtttcttct ttacagcttt ctaagtcgat acaaccaatc 1140 attcttgact atgacgaatc gaatttaacc cttcatattg tagataaagg ttttttaatt 1200 tggttgtcca tgcaagaccg aaacgaactt ctctcaaccg tgggtctgcc tgaaatgact 1260 taa 1263 <210> 112 <211> 612 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(612) <223> ICBIDGAJ_02163 <400> 112 atggctactg cgccaagcat gggaaaacta atctatcata tgacatctat agataatctt 60 ccttcgattt taaagtttgg tctgctctct cgaaaatgca tattacaaaa ccacgacata 120 cactttactg atattgccga tccagaaatc ttaagtaaac gtgagcgata taaggaagct 180 ctttcacaat atgtcttatt tcattttttt gcaaaaaatc catttgatgg tgcagtgtgc 240 gaaaagtatg gatcagaaaa tatggcaatc atcgctgttt ggagaagtat ttgtgaacat 300 aataattatc aaataattcc atcacatcca ttggatagtg atgctccaga tctttattct 360 tatggagaag gtttcaagaa ggttcgatgg aatatattag acgatagaga gcatcgcgat 420 tataaaaatg cagagatccg gaaagcatgt atggcagaat gtgttgtgaa gggatgtgtt 480 ccggtatcag attttgcata tatttatgtt tatagtgaaa gggcaaaaga aaagatttta 540 aaaatggaaa atgccgtagc tattaaggat aggatacagg ttatgcctag tatgtttccc 600 ataagtcgat aa 612 <210> 113 <211> 1020 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1020) <223> ICBIDGAJ_02162 <400> 113 gtgtttttct atacaacagg agatttgctc cagtccgatg cggaagctct tgtcaacaca 60 gtaaactgtg aaggttatat gggaaaggga atcgcctatc aatttaaact taaatttcca 120 aacaacaaca aagactatgt taaggcgtgt aaaaatggta cactacgtcc cggaaaactt 180 catgtttata aggaaagtga aaaaatcatc attaatttcc cgaccaaaga taaatggcgt 240 gaaaaatcac gaatggaata tattgaggat gggttggatg cgcttgtttt actaataaaa 300 gaactcaaca taaagagtat agctattcca ccgttgggaa gtggtaatgg tggtcttatt 360 tggaatgacg ttaagcaagt tttggcaaaa aaactagagg acacagccaa acaggtagcg 420 atttatattt atgagccttc tcgaaacttt gccacaacgc caacacagga gccaaaactg 480 agcacatcag cactcgtgtt aatggaatta aaggggcatt taaaaaagtt taacagtctt 540 cgtttgcaaa aagcggcgta tttcatggat ttgttttcct caaaaaaata ttttcgtttt 600 gttcctcata aatacggtcc ttatgatcat tccattgata tagttagtaa gggaattcgt 660 gaatttcagc agtttcatgg aacatcttct acaaaagaag ctgagaaaat tctatttaat 720 aaacttacga gtgagtcggt aaataatact ttacaagcat tgctcccttg gatcataaag 780 tcttgtgatt ttgtaaactc tattgaaact gatcatgaac tagaatgttt ggcaacaatt 840 tgttttctaa ttgaaaattc aggaggctta acagcagaag gaattgtttc cggattcaag 900 aattggtctg aggaaaaggc aaagaggttt actgaacaag aaattatcga gggaatccaa 960 aagttatata tgcttggagt tatagaaaaa aatcttgtag gttataacct tgctgcataa 1020 <210> 114 <211> 222 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(222) <223> ICBIDGAJ_00155 <400> 114 gtgacagcac agacaatgca aatcgggaac acaccttgcc gcatttacgg cgaagacgat 60 gcagaatacc tgctgctcca aatgacaggt gagcatgagc tgcaaagtat ggattatgaa 120 gtggcggcca ttgctcaaag cagccagaat tttctgtttg cggctatccc ggtggaaagc 180 tggaacgatg cactttctcc gtgggaagcc cctgccgtgt ga 222 <210> 115 <211> 780 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(780) <223> ICBIDGAJ_00152 <400> 115 ttgggaggtt caagagcgac gggaacagca acagaaaatt ccgatattga tataggaatt 60 tattatgaaa aagggaaagt tgattttgaa gagttaaaca ttaccgccca acaattagac 120 gatgcccata gagaacattt gatttgcagg gagggtgaat ggggaaattg ggttaattgc 180 ggtggatggc ttgttgtaaa tagtttccat gtggacttta ttttaaggga tattgcacgg 240 gtgaaagagt gcatcacgca aacagataat ggaaatataa ccatgcatta tcagacaggg 300 catccccatg cctatctgaa tgtaatgtac cgtggcgaat tggcatcatg taaagtcctt 360 tattcgaaag ataatgattt ctctaaatta aaggaatatg ccgaatgtta tcctgacagc 420 ttgcagagtg cattgatagc tttcttctta tttgagacaa aattttcctg tgaccttgcc 480 aaaagctact cgcagaataa tgatatatac tatatagtcg gtcatttatt ccgttctata 540 tcagcattga atcaagtttt gttcgctatg aatcaaacat attgcttaaa tgagaaaaag 600 gcggttctac ggattgaacg attctctatt cgtcctaaag actactgtaa tcgaattaat 660 gagattctga cactgacacc tgataactgc ttaataaaaa aaatcaataa attagaacag 720 ctttgttatg aggttaagga actggcagat agagcccgaa atgcaaacag gaaagtttga 780 <210> 116 <211> 264 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(264) <223> ICBIDGAJ_00153 <400> 116 atgaaatata tcaatgcaca cgcaattctc cctgatatgt tggtcgagga actgcaaaag 60 tatattcaag cgggatatat ctatattccc gctaaagacg atcagcataa atcttggggt 120 gaattgactg gctctcgaaa ggaaatcgac aaacgcaata aagtcattat agagaaatat 180 cggaatggtg tttcggttaa tgaacttgcc aacgaatatt gtctttcgat atatgccata 240 agaaaaataa tatatcagaa ctaa 264 <210> 117 <211> 1440 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1440) <223> ICBIDGAJ_01307 <400> 117 atggcaaagt tccagaaccc cggagcgttc tttctcggaa ctctggttgc tcaggagcag 60 aagttcctga agccgctgat tgaaaacgcc cgcaagcagg ggtacacccg gttcgttgag 120 ccgtgcgccg gcgctttcgc catgtcgcac atcgcggcgc agtgtgggta caagcccagc 180 gagatcgagg ccagcgacgt ttcgatgttc acctccatca tgggatatgc catcacgggc 240 cagtcccttg aggagctgga aatcagagcg gacggcttca cgaatgagga actgcttgac 300 cctgcggttg cgctctatgc gcagttgtac ctgcggactg tgaagaacgc cgggaaggaa 360 tacttctacg gcatcatgcg cgatctggaa taccgcaagg aggagcatct ggcggaaatc 420 cgcgaacagc tcgacagggc caagcagtcc ttgcatggga tgagctaccg cccgctggat 480 atgtggaagc accttgaaac gtgctatgat gacccccact gccttgtggt tgccaatccg 540 cccacctatg ccgctggatt cgagaagtgg tatgacaccg gcgggcgcat gacgtggaaa 600 gaacctgagt acggcatctt tgacccaaag accgggctga acgatctgta cgacaagatg 660 aacgatgcca agtgccttct gatgtgctac gaggagaacg ccccgggcct cactgccggg 720 catcctgtct ttgctcggta tggtgtgcgt gacggcatca acgtgtacct gactaccaac 780 cgcccggatg aggcgaccat gcttgccgag ggtaaaatga ttacccgccc gaacgagggc 840 aagctggagc cgctggattg cagcatcctg ccgcgtgatt atgaaatcac ccgcaagagc 900 aagattcaga ttacccagat cgagcgcacc gctgcccagt attacagaaa gctctggacg 960 cacaactttg tcggttcgtc tgcgcctatc aacatggccg tcctcatcga cggaaaactg 1020 gcaggcgtgt tcgggctgga taagtcggca ctcacgatgg gtgccttcgg tacgcaggtt 1080 tccgatgctg tgttcctcat gtacggcatg accgttcccc ataagaccta ccggctgggg 1140 cggcttctga ccatgcttgc acagaacagg ccgctgatta tgaatatctg cacggatttg 1200 gagaaggaaa aggccaagtc cctcaagacg gtgcagatga ccaagtaccc agaggccaag 1260 gaaatgcggg ggctgatgga gttgaccaag aaagtcccag ataagaagat gggctaccgg 1320 ctcacatacg agtcgccctt gtacgataga aacgccaaac aggcattgaa tgaatggtta 1380 gggagggaag aacgatggca gaaacagcgc gagaaaacca agtcagcagc gcagccgtaa 1440 <210> 118 <211> 264 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(264) <223> ICBIDGAJ_01304 <400> 118 atggaacgaa aatccgataa agttagacgt ctggttgcag acggcgactt caaaggggct 60 ttgcggattg caaaagactt caggctcggc atcacgaagg aacagtcctc cacgatgaca 120 agagcgtatg agtgcatggt ccacggaaga ttctacaagc agctcggcta tgatctcgat 180 gagaagatag ctgagggcgt gaagattctt gtgggcttgt acggaaggag cgaggcacat 240 gatttacacc agccggtaca gtaa 264 <210> 119 <211> 453 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(453) <223> ICBIDGAJ_01305 <400> 119 atgatttaca ccagccggta cagtaacccg gaactcaaga ccgggaacta cacagtcgtt 60 gggataacac ggggggcgcc taagttcccc cttcggtata cgcttgcagg caacatcatg 120 gagatcgcgc cgccgggtta tctgttcaac gaatacaacc gggagcggtt cacgccgccc 180 tacttccagc acatggacag agtagggacg gcgcggattg ctcatattct ccagcattat 240 gaggacatgg gcaagcccgt ggtgctttgt tgctacgaag atgtccgaaa acccggagag 300 tggtgtcata gactggtgtt cgcagaatgg tggctccaga gaacaggaga aatgatcgag 360 gagttgcctg acccgtcacc aaacaagtgg gcgaaacagc ctgaaccgca gaaagcggtt 420 gagcctgatg cagtccagat gaaaatgtgg taa 453 <210> 120 <211> 228 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(228) <223> ICBIDGAJ_01870 <400> 120 atgaaaggcc ccaagcgtta tccgccgcca gaaagccgcg cagctagcaa acatgttttg 60 gtctacccga attggatgtc tgcacagaga tatcacgaat atcaagaatc gcgtgcaagt 120 gcagcaagag cagcgcatga caaattaaat caggaagccg atcggcacaa tgcctttgtc 180 gaaaatgcta aaaagcacgg tattcccatt tccaaaaaga aaaagtga 228 <210> 121 <211> 300 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(300) <223> ICBIDGAJ_01877 <400> 121 atggttgaaa ataacgtaaa agagaatctg cttgacgatg aggaggaaat ctatgtgaac 60 ctgaatgatc tggtgaacct cagagagtcg gcggaactca aggaagccgc agatgcattt 120 gaacgctact tggaggacta tgcgctggca acaggaatgc cgcagagcgt cttgtcggat 180 atctgccatc tgtctgtaca ggcagcacac aggggaatgg aattctgctt tatgaaaggg 240 tttgagctgg gcgctcgtgc aatgcgaagc gcactggaag aggagatgat ggaggggtga 300 <210> 122 <211> 333 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(333) <223> ICBIDGAJ_01301 <400> 122 atggaagaaa ataaaaatcc ccttatgggc catgtcgtaa aggtccctgc acaggtgtcc 60 ggcatccctg acggagtgca gatgacggtg aacgcagccg tgaccacctt tgcggcggtc 120 gatggcaaac cggctggcat cgaaagcatg ggtacgggag aatgtaatat gcttgccagc 180 tatacgcggg gaacggtctc gttctctgtc cacggggaga agcccgttat ggtgagcgtc 240 cgtctggatg agttgatgag actcctgcag gctgctgctg tatgtcacca cgagcaggaa 300 gacaagaaga atgctgagga ggaaaaggca tga 333 <210> 123 <211> 477 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(477) <223> ICBIDGAJ_01014 <400> 123 atgagagaaa acatcgtttt tgattatttg ctggcaaatg cctggggttt gccgctttgc 60 cgtgtgtccg tgtcagaaga tggcttcgtt caatgtcagg agaacagaga aaatacacaa 120 ggactgcaac tggaaaaggc agaagtggat aaaatcaaat caatcgtttc agaacatacg 180 aatatattgg attatgacag taaagaactt gagtcgccag atgtgtttga tggagttatg 240 aatttttttg attttgaggc atctgatgga cgaaaagtga acttgatggc ttttaatatt 300 ggcgaagtga aaacccctgg catgagcttt tcaaaaggtc tcctagagga aggagagctg 360 gacgaaatcg tcgttccggt aaaagcaatg gaggtagtaa agacattcga ggaaatcgct 420 gctacgctgg tggcgaatgg agtggatgcc aaatacttaa ggctgacata tgcctga 477 <210> 124 <211> 933 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(933) <223> ICBIDGAJ_01308 <400> 124 atggcagaaa cagcgcgaga aaaccaagtc agcagcgcag ccgtaaagta tgaaacggtc 60 gccgacatgg gttccggtct ggtcattgcc aaagtaaagc tgaccgactt ccgcgagcag 120 gacatcaacg ctcgcattat gaagaccgag atgcagaagc agcttaccga caacatcaaa 180 aagcggggcc agcttgaaag cctcccgttc tgcgcactca tcgacggcaa aatcgagatt 240 atctccggcc accaccgcat ccgttctgca aaggacagcg gtgtgctgac ggagcttttt 300 gtcattctgg acaccaccgg cctgcggcgc tctcaggtgg ctgcaaagca gttggcgcac 360 aacgccatca gcggctttga tgaccagtcc accctgaagg aaattgccaa gatgatcgac 420 gatgttgatg atatgctgga aagctacatc ggcaaggaca tcatcggcga gcctatggcc 480 gagcttgaga agctgctgtc cccgaaggtg gagtttgact ggaagaacgt cacgttcacc 540 ttcctgccgc accagctccg cgatttggac cagcttgtga aggttctggg ttctctcagc 600 cccgacatgc tgggcgttgc cgatattgac cagcacgagg agttcatcga aaccatcacg 660 aaatatcagc agttcgccaa tgtcaagaac accggcgctg ccatccatgc gatgattaag 720 gccacggaat ccctgttcga ggacctgcac ttcgacgaga gtcaggagtg ggtgcagctc 780 ccgaacctgt ttggttcccc ggctatcccg aaggaagccg ccgacaccat cgcacaggct 840 cttgacaaga tggtcaagga gggcgagatc ggccccaaga acaagtggca ggcgctcgaa 900 tactgggctg cggattatct ggcagggaag tag 933 <210> 125 <211> 498 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(498) <223> ICBIDGAJ_01309 <400> 125 atgcctacgc ctctaaagta caatccggcg taccacgatg actgggcatg gtcgcttgct 60 atcaagggcg caacagatca ggacattgct gatgccttcc atgtttcgcg taggaccatc 120 atccgctggc ggcagacata cccgtcgttc aatgaagctt gccagcacgg gaaggaagtc 180 gccgatgcaa aggtgaagcg gtcgctgtat gaacgtgccg taggcttcga gtatcaggaa 240 aaggaaagcg tcatcgacgt agacccccgg acgggcgaac agaagccggt gcgggtccga 300 acgctcacca agaaagccgt ccccgatacg atggcgcaga tgtactggct caacaaccga 360 tgccgggatg agttctccca gacccagaag gttacgcttg acggagctgt tcagacatcc 420 ccgttcgata acctgacgga tgatgaactc cgccgtctgg ctcaaatgga cgagggcctt 480 gatggcgacg cagaataa 498 <210> 126 <211> 861 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(861) <223> ICBIDGAJ_01952 <400> 126 atgaatgaag aaacacagcc gcttttgatt gcaatagcaa ttataatagt tatttcaatc 60 gccatatatg taatttcaga atttgtttct tatgtggaac aaaagaataa agaaaagcta 120 ataagtatag tacagtcaac aagcgagcga tatcaaaata tcttggcatt gaactctaaa 180 tatgattttt atgaagttca gccatattat tatttttata aaagtttaaa cagtaaaact 240 caattagata gattcgacta cgatgaattc tttgaagaaa gaattcgaga ggataagctg 300 ctaattgaga ccttagttag tcaggttgag gaaaatcaaa aactttttag aagatacaat 360 gaggagatac atgactgggt agccccatta agaggagtag attttacaga tacgttaaaa 420 gtttcatttg aaaaatacca tgaatatgag gaagaatttg taagtgctga actcttgacc 480 ccgacaacaa caattgtatt tatatgtcaa gcaatatata ctagccccaa agggagaaat 540 tcatattcag gaaagaaggc ctacacagta gaggatttgc agattcataa gcagcatatt 600 gaggagttag aaaagcagaa agaaacaaaa gaatatcaac ggagaatgat gacgcaatcg 660 ttacgatatg acattatgaa aagagataat ttcagatgcg tattatgtgg acgtggagca 720 gaagatggcg tgaaattaca tgtagatcat attattccgg tatcaaaagg tggaaaaacc 780 gtgcgtagta atctgagaac actgtgcgag gattgcaata tcggaaaacg ggataaatat 840 gatgaggatg gaataaattg a 861 <210> 127 <211> 156 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(156) <223> ICBIDGAJ_02293 <400> 127 atgaagatgc tccacgatga tgccatcaac ccgctgttcc gggcggtggc cgagtgtgtg 60 gaggaaagcg tcctgagcag cctgctccac gccgagaccg tcaccggcta ccatggccgg 120 acggtgcagt gcctttccga cctgttgaaa aaataa 156 <210> 128 <211> 1059 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1059) <223> ICBIDGAJ_01854 <400> 128 atgaaaaaaa tctgttttgt aatggatagt ctttcttttg tgccgactgg tggcgcaaaa 60 atgatttttg aatatgcaaa ccgtctacaa aataggggat acagcgtaca gattttatac 120 ttgatgggca gttcatggaa aaaatatcat ctgccggaga aattgcgcca gtggatgctt 180 tccagaatga cttacttttc accctcgtgg tttccgcagg ataaaaaaat cgaaacacta 240 tcttattatc aagctgatct agatgaaaga gtgaaggaaa ccgatgtttt cattgcaaca 300 gaagttacaa ctgtagaatc tataaaagaa cgatttttcg aaaaaaagct ggcttacttt 360 attcaggact atgagaattg gcgggtctca gatgaatatt gtcagaatac atataagtac 420 gaaatgacta acattgtgat ttcacgatgg ctgaaagata ttgtagatca gtatagtaga 480 aaaccgtcaa ttctagttcg aaatccagtc gacattcatg tgtatcgtct gaacacacca 540 atcaaagaac gaaagctgca tacaattgga cttttgtacc atgagatgcc gcataaaggc 600 cttcagtatt cgatgaaagc agtctatcag ttaaaagaaa aatatctgga tttggaagtc 660 tacatgtttg gcgttccgaa acggccaaag gaatatccag agtggatcca ttatacccaa 720 aaagcgacac aaacgcaaac tgtggaaatc tataacaagg tttcagtatg gctttgtgca 780 acgatagatg aaggatatgg acttacaggt cttgaggcga tggcatgtgg agatgtgttg 840 gtatctacac ggtacacagg agttttggag tatgccaaag atgaaaaaaa tgcgttacta 900 agtccagtga aagatgtaga agaattggtt cataatgtag aacgtgtttt tgaagatcaa 960 aaattgagag agtcgctggt tttggaggcg caaaagtctg ttgtcaagtt ttcatgggaa 1020 aaagctgtgg cagattttga aaaggcatta gaaatatga 1059 <210> 129 <211> 2085 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2085) <223> ICBIDGAJ_00143 <400> 129 atgcgagaaa agaatgcaag cgcattatgc tcacaagggg accgagtagg aattgtattg 60 gctaaagaca gacgaccaat caatattaaa ggtggagcga aagcaaaaca agcagttaaa 120 gcgttatcca aatttggcct gatcagcttt tctaaagaac aaacatttaa gagttcgctg 180 tattctgttc attttatcaa accaatagca aacttaaagc aattgtataa tttgggcgat 240 gaggttttaa ttttatgttg taacgatagt ttgcagaact ttaaaagtcg aacaaaggac 300 ttgattgata tacttttggg ctcacagtcg gaatatagaa acaggttaga taagataact 360 tgttttcttg tagatgattg tgaagatatt gaggatgtaa tcaagcgaga cagaatagat 420 aacccggact ctaggttgat tattccattt tcatataagg aattggaaag tggaataaaa 480 gagaatgatc ttcaaaaccg gatgagaaca tttctttatg aacgtgatct ttttggtgtt 540 gcttctccgt tgcgtgatga caatcttttc ttcggaaaaa cccgatttaa tgtaatttct 600 gaattgtacg gaaaatatct ccaaggagaa cacggtggtg tgtttgggct ccgccgcatt 660 ggaaaaacgt ccattctttt attacttaga aggcgtgttg aacaaaatgg cggagtagct 720 atttattttg actgtacaaa atatcatcat ttgacgtgga atgatttttt aaatcagatt 780 attcaagaac tcagaaaaaa atataccgag ggtggggagg aaacagcgat tggcttcatt 840 tctaatgatg tagaatataa taaagatatc tcaagataca cagagaagca ggcatcaatt 900 agttttgaag aagatttgat tcaattgcat cgactgcttc acaataagcg tattctactt 960 atttttgatg aagttgagca aataagcttt ggaacatcat catcattaaa ttggagagat 1020 ggaacagacg ctttgttctt ttggcaaaca ttaagatcaa tctcacaaac agataataac 1080 attttttctt ttgtaatcac tggagtaaac ccgaagtgta tagaagatgc taaaatttgc 1140 aatcaaccaa atcctatatt taatggactc gctccacaat atattacttt gtttgattat 1200 gatgacgtga aaaacatggt gtctgaaatc ggtggtcatt tgggtttgaa gtttgaagaa 1260 gaaatatttg ccaaattagt cgatgactat ggaggacacc catttctgat acgccaagta 1320 tgcagtaaaa tgaatgaaga agttcttgaa aataaagaga ctagaccgtt taaaatttct 1380 aagtacagtt atgaaaagca gtccgataat tatcaaaata aaatgaaggc ggcaatagag 1440 caaatattag gtgttttagt agattattat ccaagagaat atgacctgct aaaagttcta 1500 gcattggatg gaagtgataa atttaaaagc gaacttcagt ttgctgattg ctctattgat 1560 catttacttg gatattgctt aatcaagaaa gaaaaagacg attactacat tcgaattaaa 1620 gcaattgaaa agcatcttca gcaaaaatat aaatttgata agacctattc ggatatttct 1680 gagatttact caatggtagc aacaagaaga tgtgcaatcg agaataaatt gagatctctg 1740 attggaatgc agtatgcgtt gcactatgga aagagtgcaa aaagaacttt gatggatgcg 1800 attgaaaaaa caacgaaaga cgatacacaa aaagccaagc tcgaatgtgc cgatttaaaa 1860 ggcgcaatgc aggaactgta ttttttacaa ctgaaaatcc taatagaaaa agattgggca 1920 tggtacgaac gcttattttc ggataaaaca aaatttggat atttttctga tgtcataaat 1980 aagaaccgag ttgatgcaca tgcaaaaaag ccgtcagatg aagatttatt tttgttgaat 2040 ttagcgttca agtactttga ggaagcatta gaagccattt cgtaa 2085 <210> 130 <211> 885 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(885) <223> ICBIDGAJ_01314 <400> 130 atggcataca atgaggaaaa gctggcccgc ctgaagcacc tgaagcagct cgcacagaaa 60 gctaaggccg agagcgacgc tgttgctact cgtgttaagg ctctggaaga tgctggcgca 120 caggccaacg tgctggagac cattaaggtc aacggcgtgg tgcagaacat cgaggataag 180 gctgtggaca tcaaggttcc cggctacact gtggagaagt ctgagaagtc cggcgactat 240 gctgctgtct accagctcat gaaggatggc gttgccgttg gcgcggctat caacattccg 300 aaggatatgg tggttaagtc tggctctgtt gtgaccaacc ccaccggcca gcccaaaggc 360 acttatatca agctggttct ggcaaatgcc accaacgaca ccctgtatat tgatgtcggc 420 ggcctgatcg agtacgttac ctccggctct gctgcgggtg atatggttgt catcgccatt 480 gatgagcaga ctcataaggt caccgcatct atcaccgacg gcgcaatcac taaggcaaag 540 ctggagaccg aggtgcagac cgccctgaac aaggcccatg agcacgccaa caaggcactg 600 ctggacacct acgaccagac caacgccaac atcaaggatg ccgtcagcaa gaagcactct 660 cacgccaatg cggccgagat ggacaagatc gctaccggcg ataaggaaaa gtgggacgcc 720 acctccacca aggttgaagg tattgctgag ggcgctacca aggtcgaggc cagcaccacc 780 gaaggcaata ttaagatcaa tggcgtggag accgcggtcg ttaccatcgc caccgacgct 840 gaggtcactg agatgctggc cgaggtcttt ggcgcaaccg cctga 885 <210> 131 <211> 552 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(552) <223> ICBIDGAJ_01311 <400> 131 atgctgatta ttttctcggt caatgaccag aaaatcaccc atgacctgaa aggccagctc 60 gtcgcaggca gcgtagacat tgtgcaggcc gcgttcaaat ttgacagctc gtgggatgaa 120 ctggacaaga tcgtcgtctt cacgagcagc gcttgtccca agcccgtccc ggtgcagttt 180 gccgatgagg cgttctacat cccgaaagat gtgctgaagc ccggcaagct ctacgtttcc 240 gtggtcggtt tcgggctgga cggccagaag aaaactacgc agaagtggga catcatgcag 300 gctatcaccg ttcagaagtg cggcgatggc ggcgattgtg acctgctgcg atatttggca 360 caaggtcagg tcgccgacgg gaaagtcgca aaggacgaag aagtcgaaga tatgctggac 420 actgtgttcg gcaaaccgga agctcccaaa ccagaccccg gtggctcgga ctccaatgac 480 aagaacgtca gcgaggacga tattgccacc gataaggacg tagccgatat gctcaacaaa 540 gtatttggct ga 552 <210> 132 <211> 1419 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1419) <223> ICBIDGAJ_01310 <400> 132 atggcgacgc agaataatgt ttcgcctgcc aagcgcaagt acctcggctc caatgcccgg 60 attgcgctgg cgaaacggca ctacgccgat tatgtccagt acgtccacat gggcaggtgg 120 aaaagagcca gacaccttga cctcgtgtgt gagaagctgg aaagcatcat ggagggaaag 180 accaagcggc tgatgatatt catgccgccg cgccacggca agtccatgac cgtgaccgaa 240 accttcccct cgttctattt gggcaagaac cctgaaaagc gggtcatcga gatcagctac 300 agcggcgacc ttgctcaaca atttggcaag cggaaccgcg ataaggtcga ggagttcggt 360 cctgcgctgt ttgggcatac catctcccaa gtgcaggcca ccaaaacgaa ctggaacctc 420 gacaacggca tgggcggcat gatctccgtt ggtatcggcg gctccatcac cggctatggc 480 gcagacctgc ttatcgtcga tgaccccatc aagaaccgcg ccgaggctga atctgccacc 540 taccgcgata agctgtggga cgagtaccag tctacggtga gtacccgact gcacgcaggc 600 ggcgctgtta tcatcatcct tacccgctgg cacgaagatg accttgccgc ccggctcctg 660 aacccggagt acggcaaggt tgaggactgg gacattatct cgctcccggc cgtttgcgaa 720 gacccggcta ccgaccctct gggccgtgag ctaggcgagg cgctgtggcc tgcgggcggc 780 tatgacgaag catgggctgc acaacagaaa gagactgtcg gtacatacgc atggtcttct 840 ctgtatatgc agacccccac accaagctcc ggcggtatgt tcaagagaga gtggtggaaa 900 cgctgggcgg cgctgccgtc cggcctgcat gacttcatcc agtcgtggga ctgcaccttc 960 aaggacaagg acggttcaga cttcgttgtt ggacaggtct gggcaaggaa aggtgcagac 1020 cgctatctgc tcgatcaggt gcgtggccgc atgagcttca cggaaacgct ggatgccatg 1080 cgcgggcttt cctccaagtg gccccagacc accagaaagc tggttgagga caaggccaac 1140 ggcacggcgg tcatcgacgt tctgaagaaa gaaatccccg gaatcatccc ggtggagccg 1200 tttggcggca aggtggtccg cgcccatgcg accaccgctg tggctgaagc tgggaacgtc 1260 tacatcccag cggcatctgc ctgcccgtgg gtgatggact ttgtggaaga aatggccgcg 1320 ttcccaagcg gtgcgcacga tgaccaagtt gactgctatt cgcaggcgaa cgcctactac 1380 aacgacaaca cgtttgatat tcgttcgctg ataacgtaa 1419 <210> 133 <211> 315 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(315) <223> ICBIDGAJ_01313 <400> 133 atggctgtga acaataccgc aaagacctac tccaacatgg agttccccct gagcatgaag 60 cgtcaggatg ctttttctct tgaccccacc tgcgtgtggc cgtctatggc tgacgcgcag 120 aactatgcga agacgaaccc gactgcctac atcggtcagg tcctctccgt ggtcgtggac 180 ggggttgcca cctcgtacac catccagaat gccgccggtg atctcgcccc gctgggcgct 240 gcggcggttg acatcgcaac cgattctgag gtgagcgaaa tgctgagtga agtattttcc 300 accgataacg cctga 315 <210> 134 <211> 1590 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1590) <223> ICBIDGAJ_01312 <400> 134 atgcccgtat ccgcaagcaa acttgtaacc ctcgctcagt tacaggtgca ggcggagaga 60 gtcaagcagg agctggcgaa gtacacgctg gcatccgaac ttggttccct cgccaaaaag 120 agcgaaatct cggaagctga cctctcggct gctctgaagt ccgttattga cggaaagatg 180 gatgcagcag acagtatgac gaccgaggca atcaacagtg ccatcgccac cgccattgca 240 aagtctgctc atgcacgctt cgagaaagtt gagaaggttc cttccaacga tgaggcgcag 300 gataatgtgc tgtatctggt gatgaatgct gccaccgggt actacgacat ttacgctaag 360 gtcggtgagg aagtcgtccg tctggatgat accaccgttg acctgagcaa ctacgcgacc 420 atcgaacagc tgaatgccgt ttctggcggc attggcggca cggtgtatgc aggcacgaag 480 gaagacctgt ctgcatccga tgattcggtt atcgccgcgt atttcaaggc gcacaccgac 540 gtggccgtca agaagggcga tgtcttcgtg gtcacgacca ccgttggcaa ctctacctac 600 gagaagtccg cctacttcta cgacggcaag gcgtgggtgg cgatgaccgg caatgtcgat 660 gccgataagg tcatcctgcg cgagaacatc acgctggccg gtggctatac gcaggtcggc 720 aacctgacca agagccagaa cggcacggcc actttctcct ccaaaggcaa gagcgtcatg 780 gatgccctga ccgagatttt cagcaagcgg ctccagccca gcatcaccgc ccagccgtcc 840 atcggcacgt tcacgctgac cggtgctggt gctgttgagg ccggcactaa ggtggcttct 900 gcggcctact ctgctgcatc cctgaatgca ggctcctatc agtacggccc ggccaccggc 960 gttaccgcta ccaactggaa ggtcgatcgc attaccaatg cggccactgc gcaggtcgtg 1020 tctgtggccg ctgcatccct gaccgctggc tctgataaca acggcggcgc gggcttcatc 1080 atcggcgatg caggcggcga taatgccgtg tccagcctga agtaccgcgt caccgccacc 1140 cacggcgcag gtgtgaccgc aaaggacaac ctcggcgcgg catccagccc tgtcgtagcc 1200 attgcggccg gcactaagac caaggacacc ggagcctaca ccccgttccg taatgtgttt 1260 tatggcacgt ctaccggcaa gcctgctctg gacagtgcgg ccatccgcgc actgggtaaa 1320 accggcaagg catacgccgc cggtacgctg accctgaatg ttcctgccgg tacgcagcgt 1380 gtcgtcatcg cctgcattgc taccgcaaag ggtgtcacca aggtcatcaa tgaaaccgcc 1440 atgaacgcag atgtcaccag cacctttgtg aaggccaccg tccctgttga gggcgcaaat 1500 ggctataccg cgaaggacta taacgtctgg gtctttgagc ctgccgttgc ttatggcaac 1560 gccgcagtcc tcaaggtaac gctgggctaa 1590 <210> 135 <211> 738 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(738) <223> ICBIDGAJ_01319 <400> 135 atgaacaaag ttacgatttt caagtacgag gaaaacaagc tggtgcgcac catgagcatc 60 aacgacgaac cgtggttcgt cctgaaggat gtgtgcgatg tgctgggcct cagcaacagc 120 cgcatggttt ctgaccgctt ggatgacgat gaaaaggggg tcagtcagat ttacaccctt 180 ggcggttcgc agatgatgag cattatcagc gagtccggcc tgtataacgt cattctgcgc 240 agcgataagc cggaggccaa acccttccgc aagtgggtca cggccgtggt gctgcccagc 300 atccgcaaga acggcggcta catcgccggg caggaggagc tttccccgca ggagcttatg 360 gcaaaggcgc tgctggtcgc ccagaagact ctgaccgacc gcgatgcccg catcaaggag 420 ctgacggcgc agaaccagat catgcagccg aaggccgagt attttgacga gctggtggcc 480 cggaacctgc tgaccaactt ccgcgaaact gccaaggagc tgggcatcaa ggagaaggat 540 ttcatcggct ggctgctcga ccacaagtat gtctaccgcg accagaagaa caagctgatg 600 ccgtatgcgg caaagaacaa cggcctgttc gaggtgaaag agggcaaggg ccggcacaac 660 gactgggctg ggacccagac gctcatcacc ccgaagggtc gggaaacctt ccgcctgctg 720 tgcaaggaac tggcatga 738 <210> 136 <211> 498 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(498) <223> ICBIDGAJ_02609 <400> 136 atggctaaac ccaaagttac aatgccggat gacctgaaga gcaaatgcgc cgctgtcatt 60 cacactgcca caacagctgc cgccgctgcg ggtgttatcc cgattcctat ggctgataca 120 attcccatca ccggtgctca aatgaccatg atcatgggtc ttgccaaagt gttcgatatc 180 cccatgacac aggctgccgc tcaatccatt cttggtggta cgatggccag tcaggcgggt 240 cgtgcaattt tctccaacat cattaaggga atccccggtg tcggaaccgt tgtgggcggt 300 gtcatcagcg ctggtacttc tgttgcattg accgagaccc ttggctggat cgttgcggag 360 gacttttata aacaaagtat cggtctcggc tcagacagcc ctttggaggg cgcaaaagat 420 gcctataccg gtttcagtga ctttgccaaa tctgtaaata ccagccagtc aaagaaaaaa 480 catttcggtg gtttttaa 498 <210> 137 <211> 633 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(633) <223> ICBIDGAJ_00289 <400> 137 atgggattca cccaccggaa gcactgctct tttattgctc cgctttgctc cacaaacgcg 60 aacttgtcgg ggcgaggccc ctccatctgc tcccgcagac cgttcggtca cttaaaagcc 120 ccactgggct ttcattgctt cgcaaacgcg aatttcactt acttagataa tggcaatgtc 180 aattttcctg ataataaaaa atacagcaga agtaaaccaa ctataattag aataccgcca 240 accactttaa tgccaattcg attaaccttg ttatttttta taattttatt tgcaaaaacc 300 aatagtagcg caccaactac tataataaaa acagatatta acggatacat gagttttctc 360 ctttcaaatt ccgatttatt gaaccaagcc gagtatacca cactcttccc acagatacaa 420 ccacgcaaaa aactcccatg ctcacatcgg aagatgctgt gcacgggagt ttttgctgcg 480 cctgttacgg cgtattgtta cttattgaag gtttcctcgt tcagcaggcc ctcgctcttg 540 gcaacgcaga tgctggcaac tgcatcaccc accacgttca gggaggtgac cagcatctcg 600 atggggcggt tgatggccag gatcagggag tag 633 <210> 138 <211> 162 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(162) <223> ICBIDGAJ_01320 <400> 138 atgatggagg gagcaaccat gacattatcc cagattccga cgaaagacct tgtggatgaa 60 ctgcggtgca gggagggcgt agacaccacg gtggctgcgc cttatgagga tgccgcagtt 120 caggtcaatg gcccggcaat catattggtc gtaaccgact ga 162 <210> 139 <211> 489 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(489) <223> ICBIDGAJ_02459 <400> 139 atggctgaaa attttagtat tgagcattcc agaacgaaaa tcactgaggt aaagaaaact 60 attgaagata aaaaacaaaa gctggacgag ttaaagcaac aaaaaaagag tcttatggat 120 gccgggcttg cgttggattc ttcaaattta gattcagctg ttcaagctac ccttatggaa 180 agcattaacg attctctgcg tgatgttgag aacaaagctt atgacgtttc gaaggatgca 240 aatcagaatc tacagagcct tgaacaaatc cggcaaaatg ttgacgatga aatcacagat 300 agtcaaaagg cgaagaagaa actcgaccaa accaagaagc tgttagacac attaggtgtt 360 ggaaaatcat tggagaaagg agtaaacaag ctggatgacc acttacagga agcaaccggc 420 ttaaaaggtg aagtcatttc agctatgcag gatttggaaa aagtctaccg tcagttagat 480 caaatttaa 489 <210> 140 <211> 336 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(336) <223> ICBIDGAJ_01733 <400> 140 atgagctgga cgctggaata ccttcccgag gccgaaaaag atctgaaagc actggatggt 60 agccaacggc tccttgtcct gaaagccatc aaaaaagtgc agcaaaatcc cctgcctgct 120 gaagaaaatg gttatggaaa aactttgggc aaccatagaa gcaccaatct ggctggattt 180 ctaaaaatca aacttcgtgc ttccggcttg cgggtcgtct atcagctgcg ccgcaccgag 240 acggaaatgc tggtaatcgt catcggtgtc cgtgctgacg aggaagtgta tgaaattgct 300 cagaaacgat ccaatcaata taatctgctc ggctga 336 <210> 141 <211> 624 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(624) <223> ICBIDGAJ_02227 <400> 141 atgggtgggt atcaagtgaa accagaactt cttgaagcgg taaaaaaaga agttacagct 60 acgaacctgc aacttctaaa atctttgcag ggaaaagaag atatttttaa cacaacagca 120 tatataaaaa tacttttttc agatacgctt ctcgaagatg ttgacttttt aaacacttta 180 agtggacaac caatatttaa ggtgcggtat gctcaaatga tcctgcggga tatgcttgag 240 caagtaatag agttcatatt tcttatgaag catccagata tgattcctga atatctaggc 300 gataatatca attctaatgc accgtttggc tctaatccgg taaatgaatt acaaaagatg 360 gcaagtggac gatatgcaga tggtagaaaa acagtatctg aaatggcgaa ggacatcaac 420 gaaaagaaat cttctcccgg acggcctgcg ttatatgaga tatatcgatt gttatcagaa 480 gaatgtcata attcatattt ctttgcaagg ctggatgatt ttaaagaggc aagagatcat 540 agcgaaattc ttgcactgtc agaagatcaa gctcagcatc ttgtgataat tgtgatgcgt 600 tttatggaag cgtacagagc ataa 624 <210> 142 <211> 1305 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1305) <223> ICBIDGAJ_01539 <400> 142 atgcaggata aacgcttcta tccgtatctg tttcttcatg cgggtattgt gactttatgg 60 gttatattgg atagaacaca taaaggaatt gcgaatgacg gagccatcaa cttattgtcg 120 attgccgtct tgctttgtta tttcaatctg ctctatcttc atgtaatgac atcacggcga 180 aaggcaacaa tatctgaatg tggctggaac ctgctttctg tttcctttat tgcggcgctg 240 atgtatgatg gattttccac cttatacatg ggtgcatttc tgttttttgc attgattatc 300 ggaataatgc tggtaagaac tgacgcaagc cggggtaaaa tggttcgctt gctgtttgga 360 attgcagcta tcatactgtc gttttttgat ttccaaattc tccctgctat aaccatgtta 420 gttggaatgt tcatgggaat tttccttgat tatagatata taaatttgaa acaggttaat 480 attcttccga ttgcccagag gaaagcaaga tatgtcctcg ctcttatgat tcccttgttt 540 acagtcgtac tttattgctt tgatttgtcc accctacaag tcaatgtatt ttttcagctt 600 ataatgcttt tatttgaggc ttttgctgtc attcatcttg gcgatatgga ggcccgttac 660 aaggagttga caaagtatta tgaattaacg aactatattg caaatgagag ggaagatttc 720 tcaagactgc ttcataacga tgtgcttcaa gacattggag gtgccaaaaa tctcctgtcg 780 cttcgctcac cagatgttga tgaaacaaaa aggatattgt ctgatttgga attgcgggta 840 agaaatatga tgaatttcta ttcctctaat atcttttcgg ggtatgcttc atgggaacat 900 atcggatata tgcttgacgc gattaagaag ctgtacccaa agaagaatat acttgtagat 960 ttcacgattg acagcgaagc aaggattgct ttgaaaaaag ataacagttt ggaacagact 1020 atgcagataa tcaaagaact tgtcaacaat gtttataaac acgctgccgc tacttttatt 1080 catttggaaa tcgcgctaaa tgaagaaagt agattcgtaa ttacctgtca aaatgatgga 1140 gcgaaaccaa atgacattga aaatattctt tcttccaaag gtggtatgct gttcttgacg 1200 gtgttgataa atgggaatgg tggtaacatt cagtatttag agaaagatgg tattttaact 1260 gcaacggcag ttttggggag aaaaaatgaa gatattacta tttga 1305 <210> 143 <211> 279 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(279) <223> ICBIDGAJ_01858 <400> 143 atgaaaattg caatcttgat tcaatgtcat aaaaatccaa aacaaatcaa tttattgctt 60 gaacgtttaa atcatccgga tattgattgc tatcttcata ttgataaaaa ggctgacttt 120 acagataaaa ttattcatag ggaaaatgtg tttgtgcttc cggatgaaca gcgtgtttcg 180 gtggaatggg cacagatttc gcaggttacg gcaacgctaa atcttttgaa tacagctgtt 240 gctggtataa gggggggggc tatgactact attggttga 279 <210> 144 <211> 648 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(648) <223> ICBIDGAJ_02222 <400> 144 atgactgctg aaggaaagat taagcaatgc tcaatcgtgc ttacacgcga ctgtaatttg 60 cgttgcactt tttgctatgt aaaaagtgct ggatatgtag cagataatcg aatcgaatac 120 gatgatctta aaagtatcgt taatttttgc tgtgaagcaa aagtcaagta tatattcttt 180 accggaggag aacctcttac atacccacat cttccggaaa ttttgcagta tatcaaaaca 240 agacgtcatc ccataacaac tgcagttgca acaaatggtg tcttgcttag caacatggaa 300 ttatgccgga tgctgattga tagtggcctc ggatatgttg atgtatctat gaaaggaaga 360 aatcggaagg aatggtgtga aatgacggga tatgatggca ctgagaaaca gcatcaggca 420 attcgtaatc tggcttcgtt gccaatagag tttacttgtt ccatggtgat aacccccgag 480 aatgttcact ccttttgcga agctgtccaa atcgctcatg ataatggtgc aaagcagttc 540 tcgttcacat tcatcatcga caacaataat gccggggaca aagatctgat ttacctgcaa 600 aagcacgacc ccataaaatt agtccgtgat ttcatttctc aaagataa 648 <210> 145 <211> 1197 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1197) <223> ICBIDGAJ_00136 <400> 145 atgtctgatc atcaggcatc tgagcaaatg gtgggctatc tttatcaggt gcgatatgcc 60 ttggcgttgt tgttggatga tgataactcc gattcccaaa taagcataga aaagtttgat 120 gatgtcgcat ttgttgacgg gaatacgcct atagaacgta tacagttaaa gcatcatgta 180 agaaaagctg gaaatcttac agataagagc actgatttat ggagaacgct aaaggtatgg 240 ctcgatgtgg tatccaaatc accggatata atcgaaggaa cggaatttct tattatcaca 300 acagcatccg ctcccaataa cactgtcgcc ttttcgttaa gaaaagaaaa taggtcacaa 360 agagatgcgg atatgataga tgcactgtat gaaaaactaa aaggtgtatg tacagattca 420 gaaagccaag gcaaccaaaa attttatgaa gcatttttgg cagcagatga aaaacttgcc 480 aaaggtttga taaacaaaat ttatattctt gataatgcaa gcaatatagt cgatgtagaa 540 aaaagtatac gaaagcaagt tcggtatagt tgtgatcgca aatatgaaga caaagttatg 600 gaacgcttgg agggttggtg gtatagaaaa gctatcgaag gactttgctc agatacacca 660 atatttatat tacaagatca agtcagatct tatattgtat ctacagggca ggagtatgct 720 gctgataatt tgccaataga tatttttgat ttaggcgatg accagacaaa cgaattgagt 780 gctatcgaca aaacatttta ccagcagcta aaattgattt gtcttggaaa ccatcaccta 840 aaagttgcag tgaatgacta ttatcgtgca tttaatcaac gtgcaagttg ggtacgaaat 900 aatttgctat acattgatga attggataaa tacgagcgac ggctaattga tgaatgggaa 960 cgtgagtttg cgatgatggc agatgcactt gaggaaaatc cgaatcttgc agaagatgaa 1020 aaagtaaaag caggaaaaca gcttcttact aaaatggaag agaaagatat tcggattcga 1080 gaaaagtgtc aagcaccctt cgttatgcga ggaagttatc atatattagc tgaccaacgg 1140 aaagtgggtt ggcatatcga ctttgaagaa cgtctgaaac agttgttggg catataa 1197 <210> 146 <211> 489 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(489) <223> ICBIDGAJ_00137 <400> 146 atgcaagagt ggaaaatgcg aacaagggaa atcgcatatc ttctcaatcc agccttttgc 60 ggaagaatac tatataccac gattcgggcg tacaacgaaa agtcgcatcg ggcatttcca 120 tttccgctgg tttatttggt tttacccttg gtcttacata aagaaacgag agctataata 180 tccagtagaa cacatctgca tatatgggct caacaaaatc cgcagctttt gatagacttt 240 cctcgaagag cgagtgagtt gattcctatt acaaatgaag cggttgaaat gctacttcag 300 acaagaaaaa ttattttgac accatctggc gaactggaag ttcctccaag gtcgaaaatt 360 ctgaatagag aaaagtatac cgattctgaa attgcggaat gccttacgaa atgtgcacat 420 atcgcaaggt ggtttgaaga tgctgggaaa gtcgaaaaca tttacatcag tttgggggta 480 agaccatga 489 <210> 147 <211> 444 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(444) <223> ICBIDGAJ_02610 <400> 147 atgtcctttt tcaagtcaat cttcaatgcc gtctgcgatg ccggttctga actgctggat 60 aagcagcagg attatgcaga gggctttgaa gggatgagtg attatcagtt aaagcagctc 120 taccgagaga tgagagcaca tccatataac gtcggcattc tgaatggaat tgcgcgaaat 180 tcagctttag agcaggaatg cgtcgcacgg ggtatcgtta tctcgaatca ggaagccgaa 240 cgccagcggc agtattggca aggccgctac tcaaaaatga gtagtcatgc actcaagcga 300 gaacatcaat ccatcatctg taaatacaga agttatgcat ccggcccagc aagagatgac 360 gattcccttt tgaaagcctc tattctgaag cctcaaataa ccgctctcga aaatatcttc 420 cgtgaaagag gactatcaac ctaa 444 <210> 148 <211> 1158 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1158) <223> ICBIDGAJ_00130 <400> 148 atgagagtca acaaaggttt gatgatagca gcaacatttg atccgaccaa aagaacctcc 60 ttgataactg tagcagatat gtgtcgtaaa attgaggaga actcgatttc tttgccgttg 120 tatcagcgag atatcagttg gacacttcag aagtgtatcg atcttcttaa ttatcaattg 180 tggggaaagg ctccggtttc tcctatttct atcaatgtta taaatactgt ggatagtgct 240 gttccgcaag tttcctttat agatagagaa atcatctcaa ctattgaacg cggtcagtac 300 tcggtcgtgg atggccagca gcgtttaacc actaactata aagcatattg taatcatgat 360 gattttcgaa atatcgtgtt agacttagga aaaggcgagt tcacagaggt gcgtgactct 420 atcaggagta atcaaattcc tgttggtatc ctcttaaata aagaggatac caaattattt 480 gagtatacta aggctaaaag cgcacttggt tctgccgatg tcttgtctgt gctccttcaa 540 gtacgcagca aaatgagaaa ctataattat actcttaatt cggctgaaga cctaactgag 600 gatgaacaaa ttgagtggtt cgaagttcta aacaatgctg gcagccgagt aagtattatt 660 caaatgcgct tttctaaact gaaagctcat ggaattgata tttataaaca gtacacaaac 720 ctctaccgta cccgtgtata tgaagcagga tacgaagatt ttttcactcc gcaaaaaacc 780 aatgtttctt acccagttgc agcattaaat cctgcgtatg aagttatcac tcagaagcct 840 cattccggaa attatgctcc tattccttct gatactaagg aaaatcaact ttgtaacctt 900 tctccagaac agcttacaca atgcttttct atgactttag ctgcactcga tcgcacttta 960 gacttcatca atgagaacac acccactcaa cttcctcgca ttgattatat taattattta 1020 ttaggatatt ttatcttcca taacgaagtt ttgaccgaaa ataacaagga aaaacttctt 1080 cagtggatgg ataatgttga tttcaccaac aagtccaatt ctgaacgacg tgatattttc 1140 accgcattga tcacctaa 1158 <210> 149 <211> 117 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(117) <223> ICBIDGAJ_00526 <400> 149 atgaaggtgg ttctggacga ggatgaattt tcagggccaa cggcccgggc cgcatcggca 60 ctggccgacg cgctggccga agaggacgac ccttaccgtg aattgaacaa ctcgtga 117 <210> 150 <211> 426 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(426) <223> ICBIDGAJ_01328 <400> 150 atggggctgg gcatttttcg cagagcattt gttgtgcgtc gcttcggcga ggagaacatt 60 gtcgatggtt atggggtttc cgggtataaa gacttcatca cgtccctgaa tgttcagccg 120 ctctccaaag atgagcttca ggcgctcccg gaaggtgaga acaccgtaaa gcgcatgaag 180 gctttcggtg atctcgtttt ccataccgca gaccgctctg tcggccgcag agccgactgg 240 cttttctatc aggggcggat ggacccggaa ggacactggt atgaatgtgt cagctcgctg 300 gggtgggacc acacgatggt gggtcactgc cgcagcgagt ttgttcaggt ttcagcagca 360 gaggccaacc gtatgccgcg ccctgaaatc cgagcagatg ggaaaggtgg gtattgctgc 420 gtatga 426 <210> 151 <211> 681 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(681) <223> ICBIDGAJ_01329 <400> 151 atgacgcttt ctgaactgaa gaagctgctt gtgcagctca cccaaacgta ctttgctgga 60 gcaaccgtga cgtatgccaa gcagagcttt gtagcaaagc ccggcagtcc gctggtcacg 120 ctgaccaccg gctccgtcaa ccggtcgaga aacccgccgg tcaaaatcat tgaaggcaca 180 ccggtagcct tttatcctgc atctgttcct gtgcagattg atctgttcac gcatggcagg 240 caggaagaag tggcaccggg cttcaccccc attgccgaaa acacggctga agatgatatg 300 ctggcctttg agagcttcct gaactccccg ttcgtaacgc agtggtgtca ccagcatgac 360 atcgccatcg tcgttcctac ggcagttcag gatttgaccg atttggtgca tgataccaac 420 tacgagttcc gggcaatgct ggaaatcgcg gtttatttca ccatgacggc catcggcatt 480 accggaacgc tggacatcga cagcgtgaag cattccgatg gcgaagatga catccaagct 540 gatgatgtca tcaacattga gccgcaggta accccgacac ccagcggcgg cggcagttcg 600 gagatgactg cccatgaggg cgaatatttc acgaatgccg agataaataa tcgacccgta 660 aaggaggaaa aagatatatg a 681 <210> 152 <211> 309 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(309) <223> ICBIDGAJ_00444 <400> 152 atgaagtccg caacgaagca tattgttatc agcaccattt tgtgtgcatt gacgctggta 60 gtctttctcg ctttctataa ccgcctgccg gcgtctatcc ccgtccactt tgattctacc 120 ggagttgcaa attctttctg gccccgcaat gttgtagtgt tcggcgtccc tgtggcttgc 180 gtcctgctga acctcatttc tggctttacc gtaaggcaga aagagaatgc aaagccgtat 240 atgtactata tcatggctgt tgttgcattc gtagcaacgg gcatcatgat ttatttgggg 300 atgaagtga 309 <210> 153 <211> 597 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(597) <223> ICBIDGAJ_00445 <400> 153 atgaacccca aaaataaacg aaccttgttt ctgacaagta caatttgcat tattttgtcc 60 atcgtagcat tcgctctgtc ccacatgggc gaggccagca acgaaaacta tattctgctc 120 tatgtgattg ccgttttgct gaatattgtt ctgaaccttg cgcttagtat caaaatcgct 180 tcgacaaacg gagccaaggc gttagtatct ttgggtaaat ggattatgcc gattgcggga 240 gttgtatatt tgatcccgca ggtatattcc gtactttttc ccgctaagac tatgcaagat 300 acttattggt atgtctttat tggcatttta tttattgtca gcggcaatta tttccccaaa 360 aaccacatca acccctatat cgggctaaag tttccatggt tattcaatga tgaagaaggc 420 tggtacaaga cgcatcggct gggcggctac acatggatat tagccggtat tgtcagcatt 480 cttcatccac tacacaatct tgtttttgta accgttccgc taatcatttt tctggttggc 540 attgtcccgt tggtctattc gcttgtcctc tattttaaga ggaaacgaag caattaa 597 <210> 154 <211> 1947 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1947) <223> ICBIDGAJ_00138 <400> 154 atgatgcaaa tacaagaact tgtgctatat ggacgcaatg gaaaagtccg ccatttaccc 60 ttttcacttg gaacggtgaa tattattact ggaaaatcaa aatcgggaaa atctgctgtt 120 ggtgatatta ttgattactg tatgggtgga tcatcttgta atattgccga tggtgtggtg 180 cgagatacgg ttgactggta cggattgctt ttacaatttg aagatgaacg agtttttgtg 240 gctcgaaaga acccagaaaa aggacagcaa acaacgagtg actgttacat tgaagtaggc 300 aaagaaatcg aatccccaca aacgggcgaa ttttcttcta acacaaatgt agacggaata 360 gaagaaacac ttacccgaag agtaggaatt tctgaaaatt tgaatattcc accagaaggt 420 caaagcagaa agtcgttggc tgcaaacatt cgacatgcgc tgtattattg ttttcaagga 480 caggacgaaa ttgcagccaa gaactttttg tttcatcgcc agtcagagaa tttcattaca 540 caggctatta aggatactat cccgtatttt ttaggtgcag ttagtgaagg ggctttggct 600 ttagaaaatg agcgaagcat tcttaaacgg cagttggtta ttgaaaagcg aaaacttgaa 660 gagaatagat acttgatggg tggcggttca acacgagcag ctgtgttgat tacagaagcg 720 caacaggtcg gcttgcttga tgcaaatatt cccattgact atcaaaacta tggaaaattg 780 caatccgttc ttgaaagtgt tgaaaagtgg aatccaagta tggaagattt tgacgatgga 840 atggacgaat tgacctcctt gcaaagtaaa ctgcatgaag ctcaaaatga tttgaatgaa 900 atcaaagaaa atcttaatag tgcaaaacgc tattggggag aaacaactgg ttacacaagt 960 gaagttgaac accaaaagtt aagacttgaa tcaatcggat tgtttgagaa attggacttt 1020 aatccgggag aatgcccatt atgttttgga aaattgacac aacctcttcc aagtgttgaa 1080 atgataaaaa aatctatcac tgctttggat aaatcgatcg agagcgttac aagagaacaa 1140 ccaaagttgc gaacttttat ttcaaagttg gaaaatgatg aacaacagaa gcaagaagaa 1200 ataaaaagat taaaaaccga gattgatagc ttataccagc aggaagatga aaaagaaaaa 1260 cttcgtgatt tgaacgtccg tagaggaaaa gttattggtc ggattagtct ttggcttgaa 1320 agtgtgcaga atgatgctac atcggaagct caagagcagc acataaaaaa gattgaggag 1380 agactaaatg aaatagatgg tgcgctaaat agagattctg ttgaggagcg taagcagtca 1440 gcactgtcgc ggatacagca gtatatgaca aaatgggcag aagagctgca gctggagcat 1500 agcgatagtc cctatagact tgacttgaac aagatgactg tagttgtaga caaatcagat 1560 cgccctgtgc cgctaaaaca actaggaagt ggctctaact gggttggagt acatcttata 1620 acctattttg cactccaata ttattttatc gaatcaaatc gtcctgttcc aagatttctt 1680 tttctcgatc agccctcgca ggtttatttt ccttcagaac ttgatgaaca aaagatagac 1740 gaagatgaag ttaataaaat gtacaagttc ataattgaca ggacggagga acttcatggc 1800 cagttgcagg tcatagtggt agatcatact gccggagaag aagatcagtc ccatcagttt 1860 gtcacggaga gctggtggaa agacgataaa aaactcatcc cggatgattg gtatgagcca 1920 aatgaggcat tgattcctgt atcttaa 1947 <210> 155 <211> 168 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(168) <223> ICBIDGAJ_01359 <400> 155 atgatgaaac tcgaagctat gaagtcttac atccgtgaga acaccctcac ccacttggtc 60 aaggaacttg ttactggagc cgacatggat gtcgcatccg ctgttgagta cgtttatgat 120 atgaagacgc tcagcaaggc tcagttcgca agcaagtact tcggctga 168 <210> 156 <211> 219 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(219) <223> ICBIDGAJ_01358 <400> 156 atgagtgcta ctgagcgcac agcccgccga tatgcttcct ccatcgggtt tgcggtgacc 60 ggtaggctgg cccggaagcc cgaatgggat ggaaggttcc agaacccgga gatcggactg 120 gacggtgagt accgggttct ggtcgatgag ggagggaacg cctactacgt caacggctgg 180 caatgtgtca tcatcgaccc ggagggcata gtcttttga 219 <210> 157 <211> 138 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(138) <223> ICBIDGAJ_02137 <400> 157 atgtctttag cagaagtttg cgcactgctg accgtcatca tcggtttgct gacgttgatg 60 gtcaccgttg ccaaagccgc atttgatgct ggttggaaaa tttctaacaa agaacacgat 120 aaaaacaaaa aagattga 138 <210> 158 <211> 567 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(567) <223> ICBIDGAJ_00756 <400> 158 atgggtttac agatgtacgg tctactccta agcgaaaggc cggcggttcg aatccgcctg 60 aggacactat ttcaaaaaat gcgaaggtca tttttccatg tgaaagacga tcttcgcatt 120 tttcatttgg aacccatcgc cagaatcata gcagtttgcg ttttgaatgc acaagcaaca 180 tccgcaaacg gctatatccc agagatgccg tttcgatggg cactcttttt gaaaattgcg 240 ataaacgcgg aattttgcct ttacaaaaaa gcactttccc ttatatttgc attgcaaata 300 agggaaagtg cttttgtctt gctcacgatg aggttactat cgcaaaggat acggtcaact 360 cccaatagcg aaaagataat acggcagcct tcactttttc agcactacgc actcataggg 420 gcgcagcgtg tcggcggtgt cggggtagtt acccagcagt ttctcggcat cggtccagcc 480 tacgggcagg ggcttggcaa tttcccgctc ccgcaggttg cagagaacca gcagctccgt 540 ctcgccgtcg taccggcgat aggctaa 567 <210> 159 <211> 168 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(168) <223> ICBIDGAJ_00757 <400> 159 atgtgcagag catttgaaga agtgagagaa gaaacaaagc atgagcagtc gattgaaatt 60 gcaaaatctt tgctagaagt tggaaaaatg acctatgaag aaattgctcg gtcggttcag 120 cttcctgttg aagaagtaaa ggcactggat acaaagaaac ccgcctga 168 <210> 160 <211> 1452 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1452) <223> ICBIDGAJ_00202 <400> 160 atgtcttttt cctcacccac atcccgggca cagcgcagcc gcaggatttt gccctggctg 60 ctgtacctgt atgcccttgt gctgttcgcc atgcactttg tccgcatttt tgacaactcc 120 ttctggggag atgaggggtt cagcatcggc cttgcccaaa tgaatgtttt tgaaatgctc 180 caagtcacag cggcagataa ccatccgccg ctgtactatc ttttcacaca gctcctatat 240 catcttctgg gcaatcacgg atatgtctat catctgtcgg ctctgattcc ctatggactc 300 gttctgattc ttgcctgtac agtgattttc agacagttcg gattgattcc cgcagttgtt 360 gtttccactt ttgcctcttt gactgatacc gctatcatgt tcaatgtcga ggcccgaatg 420 tattcactcg gcgctttctt tgtgttagcg gcctatctgg cactccataa cgttcttcat 480 tccggtaaaa cctccgattg ggtcattttc agcgtcgcct ctctttgtgc cgcttatacg 540 cactactatg ccctgatttc cgttgcattt ttctatctgg ctctgctttc tctgcttccg 600 caggataaga gcagcttcaa aaaaatcctt atcacttatt gtgccgcagt ggtcgtctac 660 cttccctggc ttctggtatt gcttcccact ttcaaacgtg ctgcggcaga ctggtggtcc 720 accttcattc cttctccgat caattgtatc ggattcttct tcaatccttc ttggacagtc 780 ctcattttcg gtcttgcatt ccttctttat ttcacagcac aggccaagtt ctcctctaac 840 tggctcttcg cacctgatac gatctggctt ttgaccggct tgctttctgc cgccggcacc 900 tccgcagtcg ggctgatcgt ttcacatgcc tttcgcccgc tttttctcgt tcgatacctt 960 tatccgctca ccgcagtcgt ttacctggtt tttggctttc ttctgtctaa agtccgttgg 1020 agaaccattc tgtccagtat tctgattttg ggaacgctgg tgtgcagtct accggatttc 1080 taccaaacct atcagcggga aaagcgcatc gaccttgcga ccacccagtg tctggaagtt 1140 attaccccct ctcaggatgc agttctttat acaacgaact acttcctaga ctggacactc 1200 tttgattatt actttccggg tcgtgtccat gctcaaatcg aatcctccaa tacttctcag 1260 tgcttcactt cttcgcagcc tgagatctgg ctctttatgg aacatgcgct ttctgatgcc 1320 gaattgaatg cagcctccga caatggttat tctcacacca atgtctgtaa cagtacattt 1380 gcagaaggcc ccggtgaaga ttccttttat tacatctaca aatttcaaaa atctgcaaac 1440 accgccccgt aa 1452 <210> 161 <211> 543 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(543) <223> ICBIDGAJ_01338 <400> 161 atgcgtgaca actgcgtgat tttctcgaca ccggaacgtc aggaactccg ggtcgtgttt 60 gacccggacg gaaccccgtt cttctgcggg cctgatctcg ctgcgattgc cgggtatgag 120 cagccgagga aagccgtcac cggcggcaac aagggagtga accgtatcga ctccgtgctg 180 cggaaggtgc cttgggacaa cgggatgcgg aaaggccgct gcgagttcac ctgcttcagt 240 gctgagaacg ccgtgaagct cctgtgccgc agaccggctc cgtatgcggc gattcgctgg 300 ctggaggatg aggtcatccc gaaaacacag gaaatgggcg aggaagttgc gcgggcttac 360 cccggatgga acaagcctcc ccagcagaag gaaaagcagg agcaggacgt aacgattgtg 420 gaagtccatc caaagcggtt tctggagcag gttccggcag atggcgggtc gctcatcgaa 480 agactggaca atatcatctt ggaatgcgtt ttgctgaaga aggaaatcag caaggcaaag 540 taa 543 <210> 162 <211> 1395 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1395) <223> ICBIDGAJ_00778 <400> 162 atggagaaat ttaccattgt cacacaaggc agcgctacct atctggaaag aacgcttgga 60 gcagatgaac tgttggatga agtggatcgc ggaatgctgg tgtcgaacca gatcagcggg 120 atgctgccgc tcaacatcca gtggatcaat gcggactgca gattactgta caatatcacc 180 ggtctgacgc cgcttgtaca ggcggcgcgg atcctggagc atgagacacg gctgagcaat 240 ttctttatgg cactgtgcag ggcagaaaaa gagtgcgacg agtatctgct tgacccgcac 300 aaaattgacc tcacaccaga gcatatttat ctggatgctg caggccatgc atatgtgatg 360 tatgttccgg tacaggcagc gccggataaa tacactccca cggaactggc gggttatgtt 420 ctacgcatgg taggcagaca gatgcctcac gacagccgtg tggtcggcgt cctgtctcgt 480 cagctgctgt acggcgagaa gttctccttt gtcgatttag agaagcagat agaagagatc 540 ccgacgcagg ctgagccgtc aaaagttgct tatgagctga aacctccggt cagtgaaccg 600 ccagtccgac agtcggaggc cggtagtgct tcgttgagac cggaacctgt aatgtataaa 660 ccggaaccga ctcccgccca tgtaccggca gaacagccag tgcaggatag tccgtttgca 720 gcacagcagg gaggtaatcc ctttattgcc agccagccgg agccgcagcc gaagaaggaa 780 caaaaggatg aaagggccga aaaggctgag aaaaaatctg aaaaagaaaa gaagagcggc 840 gggctgttcg gcggactgtt tggtggaaaa aaggacaaga aaaagcactc ggcagaagaa 900 caagataacc cattccggca ggaagcaccg gccccggagc agtcggcaga taagccggcc 960 cccgcagcag ctgcttatgt gccgccacag ccgccagtgc agcaggccgg cggccatact 1020 gtggtacttg cagcaggcaa tggcggaact gcccgcacga cgctaatggg ggctggcagc 1080 tccggcgggg tcgaagagtt gtatttggta cagaaggcga cgaaccagta tatccatgtc 1140 acccatacca atttccacat tggccgtgca gaggacgtag tggactacac ggtgcacacc 1200 cagaactgct atctgggcaa cgaccatgcc tacatcctaa tcgagaacgg cagctactat 1260 attgtggata acaatacgca gaaccacacc tacctgaacg agcagcggct ggagccttcc 1320 aagccaacgc agttccatgc gggcgatacc atccgtatgg cagatatcgt gttcagcgtg 1380 gtggcagggg cttga 1395 <210> 163 <211> 1398 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1398) <223> ICBIDGAJ_00329 <400> 163 atgaaaaact taaagaatat tgtgcttttt acaataatat ccttgttact gttctgcggg 60 tgcagtcagg aaaataaaag cgcttcggat acagtgaatc cgcaagatgg aaaaagtgtg 120 tctgaacaac aagaaactat agtggattct gaaaaagcag cggaaaacgt tacggataag 180 atgagtttgt tagaagctgt gggagagggg catgtttact tgacattccc caattttgat 240 gaactttcag taggcgaaat cagagatggt caatcaaaca aaagcgttct ttttgatgca 300 cagggaatgg ttcatcacct gtttgaagac ggaagcaggg ttgtgtctgg atactataat 360 ggtatgtgct tacttagtaa tgggatgatg gcaacagaag acggaacgca gctgctggta 420 tcatggcttc cagagaatga aaaaattatc cggtttgcaa aggatgaaga gggcgttctt 480 ctatggtcga taaagagaga agatggaatc gatgggacaa aagttacgtt taccgcaaga 540 aaaatggatg gctcaatctg ttttcaatgc gatacgacac agccagagtt ctctgagctt 600 aatccgaatg atctttatga gacacttgtg aatgctggat atgatatgaa tgcagaagga 660 atctctactc cgttcattta ttgcggagga acgctttatc gtgtccgagg atggaatgga 720 tatgtcttta taaacattgc aaatggaaaa ctccattata tttctgaatt taatgcatgt 780 cagattagaa tggaaaatgg tgtgatgttt cagacagcac cgagcattcg agttttggac 840 gatgacttta atgaactgcc ggagtggaag agtattaaat cacagcgaag tggaacgcca 900 gtattggcag aggggctgat ttaccttgat gcaagaagag atacaggtga gtttgagaaa 960 tatccatcag gattttatga tattcacttg aactgtatca tcgatttgag ccagtataac 1020 attcagccgg ttacaactga tgaaccacga tttatgaatg ggtatgctgc attgcaaatg 1080 ctgaatcctg atggggttcc tttttgggga atcataagaa aagatgggac gtggagtgtt 1140 gaaccgcaaa aggggacaat aaagagcata tatccaacga aagatggatt actggtaaca 1200 gtgagtcaag aaaatgacta ttatacgaca atcaatcagg tgggacagaa tcttagtgac 1260 gtagaaacgt ttgtatttga tggagtaaac ggatattgga attcggccta tgagatttat 1320 aatgaatcgc tctatgcaac aataaatgga gaaattgtaa gaatagataa aaatggttcg 1380 gctgaatttt tatgctga 1398 <210> 164 <211> 1182 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1182) <223> ICBIDGAJ_00450 <400> 164 atgaaaaaaa ctgaattact tataaaatca cgagaagcca tgatgtcggc tgttcagttg 60 tacaataatc ctcaaatcac gtttaaatca gaaacattta ttacattggc aattattgct 120 tggacttatt tacttcatgc attctatgcc aatgaaggca tagattaccg ttattttcat 180 aataagggaa agaaaaaagt atatgataag acaaagcatg gagcttataa acattgggag 240 cttgagcgtt gtctggattg tcaagattct ccaatcgatt ccataactgc tagcaatctt 300 aaatttttaa tcggaatacg gcacgagatt gagcatcaaa tgaccaaaaa gatagatgca 360 tctatcagtg caaaacttca agcgtgttcg atcaattaca atttttacat caaaaaattg 420 tttggaaatg tatttggagt tgatcaggaa ctcggacttg ctattcaatt ctcacccata 480 gaagccgaac agaaagagca acttttccgc aatgagaaac tatcaaataa cataaaaaac 540 tttataacag aatttgagga ctctttaagc gaggatgaac ttggtaatac acattatgca 600 tatcgtgttg tatttgcacg cgtagatgga aagcgtgtta acagcacaac agatcaggtt 660 attacattcg tacgagcgga tagtccgcaa gcgcaaggat taaatgctgc gtatacacta 720 ataaaagaaa ctgaaaagaa aaaatacctt tcaaaagatg tagtcaaatt gatgaacgaa 780 aaaggatata cttggttcaa cactggagat atgactgcat tttggaagaa cgagctaaag 840 agtagagaaa aatatggaat ctatattacc aaaaatcaat ggatgtggta tgaaaactgg 900 cttccagttg tagaaaaaca ttgtcaagaa aaggaattgc aaagacacga agaagccaaa 960 atcacatata ctccatccga aattgttgat attatgaaaa agaagggata ttcccgtttt 1020 aatgtatggt ggtttaatca aatatggaaa aacgagctcg gcatcaaaaa agaaagcaca 1080 gaatatggct gtcctttgaa atatggacat tttggatggt atgaatcaat cataccgcta 1140 atagaggatt actgcaaaaa gaatactgga agattaaaat ag 1182 <210> 165 <211> 270 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(270) <223> ICBIDGAJ_01291 <400> 165 atgagcgccg ataagctgac ggaagcgcgg gaggcagcgg aaagctcgct ggggttcaaa 60 atcccggatg tggtcgccac cagcgttctc tggtatgccc ggcgcaaatg tgagctggca 120 gagcagccgg agagctacct tccgcttctg tacgaaaccg agctgaccga ctactatatg 180 cggttggaaa tcaatcagaa aggagaaaag caacgtgagc aacgaatccg cgaagcccga 240 aattccgcag ttcccggaac tgacatttga 270 <210> 166 <211> 615 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(615) <223> ICBIDGAJ_01292 <400> 166 gtgagcaacg aatccgcgaa gcccgaaatt ccgcagttcc cggaactgac atttgaggaa 60 gaacggcatc tctactacct gaacgggctg gaagtaccca gcgtgaccac cctgatgaag 120 ccgctgtcca gtgacttcta cagcacggtg gacccggagg ttctgaacaa ggccgcaaag 180 cgcggcacgg ccatccacaa tgcggtggag aactacgcca agttcggcat tgaggacatt 240 ccgccggtgt atgccgggta ttttgccggc ttccgggagt ggtgggatag ccgcaagccg 300 gaagttctgg cgaccgaaac caaggtctac cacaaaatcc tgcggtatgc aggcacggtc 360 gatctgctgt gcatcatcga tggcagggtg acgctggtgg actacaagac atcggcacag 420 gtgaacagca agctctgcgc tgtgcagctt gaagcctatg acagggcatg ggagagccac 480 gacatcaagg tcgatgaccg gctgattctc cacctgtcca agaagggcta tcaggaagtg 540 cgctttcccc ggagtgggaa gtgctggtcg gtgttctcgt cattgatgac aattaagaac 600 tacatgaacg agtga 615 <210> 167 <211> 711 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(711) <223> ICBIDGAJ_01293 <400> 167 atggaaaaag aaactatggt ggcaatcgtt ccgaagaccg aaatcgttga tgagcagcag 60 ctctcccgcg atgtgaccga catcgagttt caggcggagt ctctggttat ccagaccgat 120 gaagattacg cctttgccgg cgagttcggc aagatgctga agaaaaaagc gtcgcaggtc 180 acgacgttct tcaagcccat gaaagacagc gcctatcagg cccacaaagc ggtttgcgac 240 cgggaaaagg ccatgctgac cccgctgcgc aacgccgaga agacggtcaa gcaggtgatg 300 agcgcctaca ttgcagagca ggaacgtaag cgccgggaag ctgaagaagc tgctcgacgg 360 gcagcggaag ctgaacggga gcgcaagatt caggaagcgg ctacgctgga agccgcaggt 420 gatgcagatg gagcggaggc cgcctttgag gaagcagcca tcatggatga tgctgcaagc 480 tatgcggtag tgcctgccgc agccaccccg aaggtctccg gcgtcagcac ctcgaaagac 540 tgggaaatcg ttgaaataga ccccaaggcg gtcccgctgg cggtggctgg cgtcgaactc 600 cgcccggtcg atcaggccgc tgttatgcgc ctcatccgta cctcgaaggg ccagatcgag 660 attcccggca tcacctatcg tcaggtcgca aaaatgagct tcagggggta a 711 <210> 168 <211> 753 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(753) <223> ICBIDGAJ_01295 <400> 168 atgccgtgga taagcgtaca tcaggaggtg gacggtacga agctccgtag attataccgc 60 gccatcgggt gttccaagtt tgaagccctc ggcatcctga acttcctgtg gttctggggc 120 atgaagaacg ccgatgagac cgggatggtc aaggatgcag acctcgaagt cctgagccga 180 tacctgtacg gctgcggcga ggactgccag ctcgacatgg gcaaagtggt tcaggccctt 240 gtggataccg gctggattga tgtggcggct gacggctttt acatccacga ctgggacaca 300 tggcaggaac agtggtataa gctccagaaa aaccgcaggc tggatgctga acgaaagcgg 360 aaagcccgtc agatagagcg agaggccgca aagcctacac cgaagacccc ggagccggaa 420 cagatggaac ctcctgtgga accagaagtc aagccgcctg caaagccgaa acccgataaa 480 aaatcctatg cggagttcgt gaagatgagc gaagcaaact acgacaggct cgtgaaactg 540 tacggcaaag cctttgcgga cgcctgcatc gtagaactcg atctctacaa gggggcgaag 600 ggcaagaagt acaaggatga ctaccgggcc attttgagct gggtagttga ccgtgtgaag 660 gaaaagaaac cggggctgct ccagcagagc atgagggagg cagcaccgga tgaagacaat 720 ccgttcagag agtggggtga gcagagtggg tga 753 <210> 169 <211> 402 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(402) <223> ICBIDGAJ_00911 <400> 169 atgggtttgt atgagggcat caaagatgtt gccaaagttg tacagcaagc agataacatt 60 gaactgtatc ggcaactatt ggatttaagt gctcaagcgc tagatttgca agctgaaaac 120 ggtcaattga aggaagaact tcatgaactg aaaaagaaac aagatttgga agataaaatt 180 attcggcacg gtgcactgtt tttgcaattg aaagaccaac cggaagaatt catgtactgt 240 acacattgtt gggacagtga aaagaacatc atacaactcc ggtgtgatag tgatggtgaa 300 ttttactgtc cgcactgtca tatatccgga atttatgatg aaaataaata taaccagtat 360 caacaggcaa tgttaaaatc aatggaacca gtaacttggt aa 402 <210> 170 <211> 201 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(201) <223> ICBIDGAJ_01349 <400> 170 atgggtttga acagagtaag agtcgattct gtagccaagt tgcagaagaa gaaaacgatg 60 gcggaattgc aggaggagaa tgaagccctg aaaaccaagg tttcttctct ggaaaccaac 120 ctcgataata cccagatggc gctgtgcgac gtgtacgaac agctcatcgc ggtcacatcc 180 gccgcagata aggaggcata a 201 <210> 171 <211> 942 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(942) <223> ICBIDGAJ_00339 <400> 171 atgacattgc aagacctgat gatgctgtat ggtgtcaccc tgggcaaacg gcgcactgca 60 aagcagaaat atctttttgc ccagcagctc aacgagagcc taccgccgct gggctggccg 120 gtgcgggttc aacagaggga aggacggttt tccaagatcg aaaacctgat tgccggggat 180 ctggcaaatg caaaggtcgt cattgcggtc ccctttgata cgccggcaaa ggcgctgcgg 240 ccccagaaat actatccgtt ccatccggac aaaaatgttc agcagcgggg gagagacctt 300 gcactgcaat gcgtgctgga actgctctgt ttcggagcgg cctgcctgat gttctggtcc 360 ggacggggaa ccggtgccat gctgccccgg acgctggcgg cactgctgct ggcgggggta 420 ggtgtctggc tgctgctgcc ccatgcaagc ccctgcaact tcagccgctg ttccggtgcg 480 gtcgccactg ccgtaaagct ggcggaggac ctgagcggtg aggagaacat cgcttttgcc 540 ttctgcgacc atgcagtgga taactatgac ggcttccggc ttctggcgca ggaggtgcca 600 actgcggcaa ctgttctgct gctggacaat ctgaccagcg gcccggcggt ggcgctggcg 660 cacggcgagt atcggaaaga ggcggcggaa cagctgtgca gtttgctgtc ggcggataag 720 gtctatgacc ggaactaccc ggaggaacag cggcagcgga atctgctggc gctctttccc 780 agagggatga tgctcagctg tggacgagtg gaaaaaggcg aatttgttgt ggagaatacc 840 tgctgtgcac aggaccatgt actggatctg ccccggatgg agcggatgga acgggcgttg 900 gccgattttg caaaacagaa agcaaataag aaggagaact ga 942 <210> 172 <211> 249 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(249) <223> ICBIDGAJ_01345 <400> 172 atggagcaca ttgaattttc atgtccgccc ggtgagctgt cctgcatcat cgggaatttg 60 ttcgtcagcc ttgaacctcc ctgcaaatat gtgcgaagta cgcacctgat gctctgcggc 120 atcactcaca gcggaaacag cggtcgcctg actgttttgg gcgaccgctg ctctttctat 180 gggcttgcca gcgatttgga ggctgcgagg aatggcccct gcctcgaaag aaggtgtgac 240 cgtggctga 249 <210> 173 <211> 393 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(393) <223> ICBIDGAJ_01759 <400> 173 gtgacagtag gaaaagcaat cgaaaccgca gaccggctgc ggcccaacaa cgggtttgac 60 cgcgagctga agatcttatg gctgcggcag gcggatgcgg ggctgagaaa gagcgtggtg 120 gacaagagcg acaccaccga ttttgatgcc gtgggtgcgg acatcttata cgaccgggag 180 caggagcttt tgcggcagga cgcggagttg ctgctgccgg agccctacaa cagctactat 240 gcccactatc tggcggcaca gatggacgcg gccctgggcg agaccgaccg ctatgccaac 300 gagatgcagc tggccaacga gaaccagcag gagtttgcag cctggtgcag gcacacctac 360 ctgcccagga tggccacgaa gtggaggtac tga 393 <210> 174 <211> 1401 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1401) <223> ICBIDGAJ_01755 <400> 174 atgttatttg ataccttacg gagaaagaac caggcggaac aggaagagcg ggaatggaac 60 gccaaccgcc cggcggacta tgtgagccgg aacaaggacg caatggacag cctgaccggg 120 cagatcggca gcgggttcga ctgggacacc ggcagcaaag cctaccagca gtaccgcgcc 180 caggcccagg ccaatgctgc cgccagcgcg gagaacgccc aggccaacgc ggcgatgctg 240 gcgggtgggt atggcagcag ctacgccgac agcgtggcaa agcagggcca gcagcaggcg 300 ctgagcggca ttgacaatgc ggtacccggc ctgagaggcc aggcactgag cgaataccag 360 aaacagcaga acgacctgct gagtgccctt tccggcatgg ccaacaccga ggcgctggat 420 cgcagtgcct acggcagcaa ttttgccaac tacacggcgt ggcagaattt ccttgccaac 480 cagagcgaac aggcccggaa cgagaacgac aactactgga acaacctctg gaacacggta 540 aagaacatcg gctcggcggc tctgacggcc tacgatgggt acaaggggta cacgcagcag 600 cagtgggaga acgactttgc ccgggaacag tgggagtaca acaagaaccg caccgaccag 660 agcgatgccc tgaacgccta tcagcaggcg ttcaacctgt acacccaggg agccggggat 720 gcttctgccg atgtgctgaa ccggtacggc ctgaacaagg atgcctttgc caactacacc 780 ggcgcaccgg tgacccggga cgatcaggca agcgtgctga ccacggcggc ttcccttgtg 840 gcaaacggca acagcgaggc ggcggccaac ctgctgaaga tgtacgggct ggacagcaat 900 gcagccggtt cttacggcac cattgcaaaa cgtcagctgg cgacccagct ggcaaaggcg 960 gcagctacga agagcagcag aagttcgaga agttccggcg gctccagcaa gagcggaagc 1020 gggtggacaa acagccaact gctgacggcg ctgggtaagt atcagagcct gaaggatgat 1080 gacccgacca agagcgtcta tgcgaacatt ctggccagcg ccggaatgct gccggacggt 1140 gacacgggca caacagcagc gaccggaact ggcagcgggc tgatcgcccc gctggcgaat 1200 ccgaacaagt gggccctgcc cgggggaacc acgggaggga gcacgggtaa gagtaccgga 1260 atgccgtaca gcaatgccct gagctatgca aaggggtgga gtgcagaagg ggtggattcg 1320 gatacgatct atgccaggct ggtcaacatg ggcataaatg atgacgtggc ggccaaggtc 1380 tggaatgcga tgggatggta a 1401 <210> 175 <211> 234 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(234) <223> ICBIDGAJ_02196 <400> 175 atgaataccg taacacaaac catgcagttc cgtcaatcac ttttgaacta cgcagagaag 60 ggcggcgtga accgggcagc aatcaagtat aatatgaacc gcaacgacat tcattctctt 120 gccaatagat tgtaccggcc catcatccga actagcgcac agaagcggag ctttaacgga 180 tcacaaactt ttgtaggaga aactcaaaca cagagctggt cgttctttag atga 234 <210> 176 <211> 201 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(201) <223> ICBIDGAJ_01757 <400> 176 atggcagata ttacgaggct tggcgagatc gccatgccga aactgagtga caacatggcc 60 ccggaggaca ggcggagcat caacaactac ctgatgcagc tgcgggacca aatgatatac 120 atgatgcaga acctggacga gacgaacttc agcgacacca tgcgggacaa gctggtggct 180 atggggctga aggtggagta a 201 <210> 177 <211> 780 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(780) <223> ICBIDGAJ_01756 <400> 177 atggcaagag gagaatggtg ggagtacctg atcccgggcc acaatgtggg gctgatggta 60 ggggatgtgt atgacggcat taccggcaac agcgaaaaga atgcgggcac cggcgtgttt 120 ggaaccagaa agaacggttc caacagctac cagtacgccc agagcaatga ccgggtgacc 180 acggcaaaga acaatttgga ttacatcaaa ggacagaagc ccggggagta tcagagcgag 240 tacggcagcc agatcagcgg cacgcagagc cagctggaca agatgaaccg ggacggcttt 300 tcttacgact acaccaagga cgcagcttac cagcagtaca agaaccagta cacccggggt 360 gcggagctgg ccagcgagaa cgctgccgcc aacgcttcgg cccgcagcgg cggctacggc 420 aacagctggg gcacttccag cgggcagacg gcctaccaga gcaccatgaa cgggctttcg 480 gacgtggcag acagcttata caaccaggct tacaacgaat atgccaccaa aaagagtgac 540 ctgggcaacc ggctgagctc tttgcagcag caggaaaagc tggcgcagga tgcttacaac 600 acccgcctga acaattacta tggccagctg aacagtgctc agaccgagta tgccaacgcg 660 gtgggggcca accagaagaa ggatgcgaac aacaccaact tctgggggaa cgtattgcgg 720 atcggtgcac agctcgccgg gccgcttatc gtgaagatga tgacgggtgg cttgctctga 780 <210> 178 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_01751 <400> 178 atgaaaacgc tgaacaacct gaaactccgc atcatggtgc gggcattccg catccggctg 60 aacaacggcg aagcctttga ggcaatcgcg gcggattacc ccgccctgac cgcagatgac 120 ctggaagcta tccacgtcca gctgaccgag aaggaggcgc agagcaatgc ccagaacaat 180 acttga 186 <210> 179 <211> 219 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(219) <223> ICBIDGAJ_01287 <400> 179 atgaatagct ccaagctcaa gggcatccgg gtcgagaagg gaaagaccca gaagaatatg 60 gccgaattga tcggcaaatc gcttgttacc tactccaaga aggagcgcgg agaagtcgag 120 ttctccaatg aggaaatgag cattgtcgcc aaggcgcttg acctgaccag cgatcaggtc 180 aacgctattt ttttcgacga caacttaccg aaagggtaa 219 <210> 180 <211> 633 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(633) <223> ICBIDGAJ_01285 <400> 180 atgacgaagc aatgtaccgg ggacgagctt atcgtcttcg atgatatgcc cattggtaaa 60 tccttgagtg actactggcg ctggaacgcc tcagacctgc tcaacaatac cctgcggggc 120 tcctactgcg agttcatcgt atcggccgcg ctgggcgttg atctgagcgg aaccaacgat 180 gactggactc cctacgacat ctctttcccc tacaactggg tatgtaatgg cgaggcccgc 240 gatgaagtgc gcatcgaggt caagagctgc gcatatcttc aggcatggcg gcagggcgat 300 ggcaggctgt ctaacatcca gttcagcatc cgtccaacaa gagcttggga ctccatcaac 360 ggctatgctg aggaggtcat gcggcagtcc gatgtgtatg tgttctgcct ctataccgag 420 accgtgcggg aacgggccaa cccattggtg ttggatggat gggacttcta catcgtaccg 480 actcatattc tggacgagca gtgcggccct cagaagacca tctctctcac tatgctgcaa 540 aagctggacc cataccttgt agactatggt agcatccgtg atgccgttgt cgattccttg 600 aatgtgtacc cccccccccg atattttgca tag 633 <210> 181 <211> 1002 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1002) <223> ICBIDGAJ_02195 <400> 181 atgtactaca aaatcaggaa tgatgtgttg ttccgaaaat atcagggaca tggctatata 60 acagacaatt cagaatacgg ctatcgtatg ctcaatgatg cccgtatata tccgggtgaa 120 aaatatgtct ctgccagtgg agctgtcatg ttgagtatgc tgagcaaatc tcctcgcgcc 180 attgatgata ttgttggaga tttgtcgcaa atcttcactg gtgtcgagta tgaaacgttg 240 aaacaagata ctatagagtt tttcgactgg tttgtagatg agggatttct tagttgtggt 300 aaaacggtcg acacttgcac agatcgattt gttgcagata tcctgagacc ggacaatcgc 360 aatccggctc aagatggtat ggcaagaagt gactgcactg gtggagaaat cagtccaaat 420 gattttctta gaagcatcca tatcgagatt gctgatgcat gcaatgagcg ttgcgtacat 480 tgctatattc caaatgaacg caaaaacaac gcgattgatc ccgccttgtt ttatcgactc 540 atcgaggaag ggcggaagat gaacatcatc catgttacgc tgtccggagg agaacctctt 600 cttcacaaag atattttagg ctttttgaaa agatgtagag aactggattt gtctgtaaac 660 gttctgtcga atctgacttt gttgacggat gatatcctat cggaaatgaa gaaaaatcct 720 cttctctctg tacaagtttc cctttattct atggatgcca cagtgcacga ttctatcaca 780 aagttaagcg gaagctttga aaaaacaaaa gcgggagtcc ttcggttgtg tgatgaaaat 840 atcccggtac agatatcgtg tcctatcata aaacaaaata aagacaccta tgttgatgtg 900 aactgcaccc catttgttag acagtatggt atactgttta ggaaatgggg tgtttttgta 960 tgccaaaggg acaacgaaag tacaacggag ctcaaaaggt ag 1002 <210> 182 <211> 180 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(180) <223> ICBIDGAJ_01289 <400> 182 atggctgaca tccaaacgct gaagaagttg cttgccgaag aatatggcat cacaaccgca 60 agagaactcg acgaagccat gaagaaaatc ggaggattga atatcggcgt gtttgcatcg 120 ccggtaagaa aggatggaac gaaacatgaa aaagtacgca gtattgcacg agccgggtga 180 <210> 183 <211> 1329 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1329) <223> ICBIDGAJ_00909 <400> 183 atgaaaaagc ctaaaattat cggattgaat acaacgtttg cgtctttaaa ctatccaaac 60 tggatagaaa caggattttc cgagtctgta tcactccttg actatgaagc ggttgtaata 120 aatccggctg aattattgag agagtatggt tataaatctg ccgaatacaa agattatcgg 180 ttgttgtctg aaacctgctc aagacaaatt gtagctgatt ttcatcgaat ttatggtcag 240 gtggttgaac tgctaagaaa tggaaaaaac atctttgtaa ttctaaacgc ccccgatgtg 300 ttccgtatca gagaaaactc aggggcaaaa tatagctttt tcgattgttt ttcttttctg 360 ccagtacaaa tttggataga gcaccttaaa gggcatgagt tgattacaac ttcagagccg 420 ccttatgacc tctattttag aaaaaataaa gatgcactat tctatgaatg tgtaatagaa 480 cgcctttcca gtgcagttcc tcttgctaat attcggggaa caagtaagct gatatcagcg 540 tatgtggaat atggacatgg aaaaattatt tttctgccac cagttaaact ggagggcgat 600 gttggaacaa aggctgcatt ggaagtaaat ggctcaagat ttatagaaag cattatggaa 660 ttacaccatg cactttctgc gccaagtgag acaaacgaac ttccctcgtg gacagaaaat 720 tttcatattc tgaatgaatt agaggctatc cgactaaagc atcagtctga agctgaaatg 780 caaaagctga aagaaaaaat tgaggcagag caaaaggcaa ttgacaatat tacaaattac 840 aaaagattgt taaccgaaac cggagaaccc ctcgaaaata ttgtaaagca ggttctttcg 900 gagcttggct ttgaactttg catggcggaa gaaaaacgca gtgatgtgat tgctaaatat 960 aataacattg atatcgttgc tgagattaaa ggcgttggca agagtgccgc tgaaaaacat 1020 gctgcacagc ttgaaaaatg ggcttcgcag tttttaatag accatgggca tcaacctaga 1080 gcactgctga ttgtaaatgg ttataatacg ttacccttgg atcagcgcac agaagaagtg 1140 tttcctgatc agatgttgaa atacagcaca agccgcgagc agacgcttat cacgaccaca 1200 cagcttttat gcctgtttgt tgaaattcaa gagcatcccg attgtaaaga agaacgaatt 1260 caggagcttt tgtctacgat tggtcggtat aaccgttata cagactattc tgagtttatt 1320 acacaataa 1329 <210> 184 <211> 711 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(711) <223> ICBIDGAJ_00908 <400> 184 atgtcgttta tcatcaccgt ttataccagc gaagggattg tcatggcaag tgacagtaga 60 tcaacctata acttcacaaa gcaacttggt aatggaaatt ttgaaacctt gtgtggtgca 120 cagattactg atacaaccta taaaacgttc cagtgtaatg agcatatcgg catttccact 180 tgtggagatg cgagtatcaa tcaaacgcca attgctggat atattgaaaa attcattcat 240 gaaaaagtca atgcagatag cagtgttgga caagtatcaa atgatttgct gaattacttt 300 agcaatgtca atccacactt aaatactcat tttattattg caggatatga ttctaataat 360 acactacctg ttgtgaagca actttttgtc gctgatcaat ctataaaaaa ttttagtacg 420 aatttttccg gtgctgtttg ggatggtgaa accgcaactc tatccaaact gtttacacag 480 ctttatgcca aaaatcctga tgaaacctat tgtgccattc aaaatcatgg aataaatttc 540 aacttcttca acttgcaaga tgcaatcaat tttgcccagt atgccgttga tgtcacgatt 600 aaaacgatgg cttttgaaaa ctgtgtaaaa accgtgggtg gtccagttga tattcttgta 660 atcaagccga ctgaatcttt ctgggttgcc agaaaagaac tacatgcgta a 711 <210> 185 <211> 891 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(891) <223> ICBIDGAJ_00770 <400> 185 atgctgattg taaaattgat ctgtctagtg ctgggtacgg cactggcagt gctgttcatc 60 cttttcaccc tgcggggcag aaaagaggac tggcgcattg aaggcgtgcc gcagaaggaa 120 ttcagtgata aagaactgtg ggcggcaggc tttgccatgc agcaactgcc ggtgttttcc 180 atggattcgg ctgtcggcaa aaaaatgatg tcggcttctg ccattctgca cccggaaaac 240 ggcggacgtt ttgtggaata ctgggcgcgg ctgtactggg cgcgcacgct gtccatgtcg 300 ctgctagtgc tggcgctggc gttctgtgct tcggtgttca tggacggcta catggtattc 360 gttgtgctga tcgccggtgt ggcaatggtg gccgtcatct attccaacgg tgcaaatgag 420 atgagcaacc agcttaaaaa gcgcagcgaa gagtgcatga tggagttttc taacgtggtt 480 tccaaactga cgctgctgat gaactgcggc atgatcctga aggaagcctg gtacatcgtg 540 gccaagagca agaagggtgt catttacgac ctgatgcagg aagcctgccg cgaaatggat 600 aacggcacgg ccagtgccga ggccatttat aactttggcg tccgcaccgg ttcgccggaa 660 gtgcgcaaat ttgccagcat catcatccag aacattgaaa agggcggctc ggacgtgacc 720 accatcatgc gccagcagtc ggatgagctg atctcccagc gccgccagat gctgctgcgc 780 cgcggcgacg atgctgccgc acagctgctg gcacctacca ccatcgtgct ggtgggcgtc 840 atcatgatca tcatggtggc ggcaatgacc ggcatgagca cggctattta a 891 <210> 186 <211> 237 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(237) <223> ICBIDGAJ_00771 <400> 186 atgaacaact tcatgaacaa gctgtatgtc aaggctctgg ttactgccaa catggcaaag 60 aacgagctga agaagatgtg cgaagaggac gaaggcatgg acatcattgt caccatcgtt 120 ctggtggcac tgggcatcgt gatcgttggc gtcgttgctc gtattgcaag tgatgtcatc 180 ggcaaggctg accagcaggt cagcggtttg gacagcacct ttgcccagct gaagtaa 237 <210> 187 <211> 237 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(237) <223> ICBIDGAJ_00772 <400> 187 atgcgaaaat tatcaagggg tcttttaaaa gcggaaattt tactctggaa tatgggcacc 60 ggcctgaaag aaaaatggcg cagggctgca caagatgaaa gcggccttga tgtgatcatt 120 acggtggcgc tgatcgctgt catgctgatc gtggcgggac ttgttgtcaa gctgctgggc 180 cgggtgctgg agccaacggg cacatcggtt ggaaactttt tgagcggacg cgtctga 237 <210> 188 <211> 636 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(636) <223> ICBIDGAJ_00773 <400> 188 atggaatgga tcattgcggt atgcagtgcc gggctgaacc ttgcggcagt ctggctcgtg 60 cagaaaaaaa cagggcttaa accggaaaaa caaacgcagt gggcagcggc tttgcttctt 120 gcagcggcgg gcggctttgc cagcggatat atgctggttc tgcgggcggg cacatacccg 180 ccgaatctgc tgcgccttgt gttgctggga acgctgctta ctgcggcagc gtatatcgac 240 gcactgagcc ataagatccc caactggatc gtgctgtgca cggcggcagt ttttgcgggg 300 tgcacggttc tggactttgt gctcagcggg acagacgctg tgcccatggc actcaacagc 360 gttctggcag cagcagtgtt ttttgtggtg tttttccttg tgcggctggc gtcacgcggc 420 ggcgttggat atggagacat caagatgatc acggcagcgg cgctgatcct gggaatatac 480 gggacattca gctttttgct ggtttcgcat gttcttgcgg cggtggcagc cattgcactg 540 ctggtcagca aaaaggcaac acgcaaggac ggcctgccgt ttggcccctt cttctatctg 600 gggtatctgg taacgatttt gacgggaatg ttttga 636 <210> 189 <211> 1338 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1338) <223> ICBIDGAJ_00774 <400> 189 atgaaaaaaa cgcgtcttgt agcgctggtg gcacttgtgg tggtctgtat tgcgggttgg 60 gcgattctgg gcctgaatac catgaacgat gtcaaaacgc agcagaacac ggtggaagcg 120 gcgcagtatt accgcgggaa aaagctgttc cagctttcac tgcagaacta ccagagtgcc 180 attgcagcaa aacccacaca ggcgctgtac gatgagtatc tggcagcctg cgcggaatat 240 tatgaggact gcccgacgag aaatgtgcgc aataccgaag aatcggccta tgcggcggcg 300 gttgcggcat acccggagcg cgccgattac tgggaaaagt atgcggcaat ctattatgaa 360 gacggcgatt acgacacggt ggtcgatgtg ctgaagagcg cggatgccgc caaggtctcc 420 ttcaatgata ccatgatgca gtactggaac gaggcttact atgcctgcga gacctctgct 480 gcaaattatg aatcgctggc accggctggc atggatggcg tgtatctggg ctggaatggc 540 gaggaaaacg ttcttttcag cagtgcggac ggcgaccttc tggatcagag ctacgcattc 600 gttggcccgg tcgggcagga cacggcggtg ctgtgcagca gctatgaagg cgagagctat 660 gttttccagc tcagcaagag cctgatggtg ggccgtttta tggcgcaggt cgagcaggcc 720 aacggttacg gccagggcct gatccctgtg cagctgaagg gccgctccga ctggtgctat 780 atcgacctca acggccagaa atacctgaac ggctatcagg ctgccggcat gttccagaac 840 ggcaaggcac cggtgcagaa agacggcgca tggatctttg tggatcagac cggtgcacag 900 cagggcgaca gctatgagga aatccagctg accgaaaatg gcagctggct ggtaaacggc 960 gtatatcttg ccaagaaaaa cggcaagtgg aacctatatt cggaggccgg cgagcagcag 1020 ggcgcactgg atgcagacga ggtcgatctg aaccgcggca atggccttgc gtttgccaag 1080 aacggcaagt ggggctttgc agccaatgac ggcactgcgg tgatcgcacc ggaatatgat 1140 gcagccaaga gcttttccgg cggcgttgca gcggtgtgca aggacggcaa gtggggcttt 1200 atcaatggca gaggcacgca ggtaatcgac tatctgctgg ttgaagccgg atatttcgac 1260 gccaacggca agtgccctgc aaagatggac ggcaacgaca cgcaggtgat gctgagctgg 1320 cgtgtgaagc gcagctga 1338 <210> 190 <211> 654 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(654) <223> ICBIDGAJ_00775 <400> 190 atgaaagagt ggaaacaaag ccttttgcgc gtacaggaag atggtatgga ggccattgag 60 ggcctgctgg tcattacgct gacgctgttt gttctttttt tcatctgggg ttatggattt 120 ttgctgttcc agcaatttgt ggtgatacgt gctgcagatg aaacggccaa caaaattgcg 180 cagacatatg cgtacgcaga aacagacccg atcacgggat atatcagcaa agaagtaaaa 240 gttgcattga gtcccagccg ttaccaaagc ggaaaactgc aagaaaaaaa cgaacagcgt 300 gccataaaat atggaaaatg gcttgttcgc aaggggagtc tggcaacgca ggtcgggatg 360 ccggtcgttg aagcaaagac tgtctacgat ggagttgcac agcgccatgt ggttgtgaat 420 atcacggccg agtacaggat tccgtttggc aatttcttgg agctgtttgg ggtcagcggc 480 acgcgcgttt actatgcgac ggggcgggcg atgtgcacag atctttcgca ctatatcaat 540 accgtggact ataccaagac gttgaattat gtagtgagca acgttgcaaa gaatgattat 600 gttgatctgc tggagaaagt tcttgcattt atcgtgaaga aaaaggattt ttaa 654 <210> 191 <211> 2787 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2787) <223> ICBIDGAJ_00776 <400> 191 atgaaaaagg acaaaatgat aaagaatacc tgcggcgcaa tctcattgat gcttgcattg 60 ctggtcgtgc cgttttatgc ggtagcgggt attctggtgg aagcaagtag atatcagtct 120 gcattgacgg gcctggatga tgcgatgaac accagtgcac tgtcggtgct gtcggattat 180 gattcgtttt tacaaagccg gtttggtctg cttgcaatgg cgcagaatga tgacccgtcg 240 gtggataatg gatataccgg caacaaagac cttgaggaag cattccaaaa gtacctgaat 300 gcgcaggata cgaccgatac ccggagcttc cgcacaacaa gtgcagcggc ggcaggcgta 360 tatccgttgg cggacacgga tatcttaaag gcacaggtcc tggactatag cacgctgact 420 ctcccgacgg tcctagtctc cgagttcggc agtacaggcc tgcaggatat catcaaagag 480 gtacagaaca gcattccggg ccttaagttc ctgaaggtcg gcagcagcat tgcggatacg 540 gcaaccaaaa cgctggacgt aacaaaaaaa ctggaaaaag ccaaggacag cgtaaaatcc 600 ctgaacgaga aaacgacctc ctatgattcg gcacacagcg cattcgatga cgcattgaac 660 gagctgaaaa agacgatggg agaaaaaccg ggagaaaatg cgaccgtcga tgagctcgac 720 gcatacaata agcggtatga gcagacactg gagaatgcgc agaaagccaa aaaggaatac 780 gaaaagaagc tgcaggcaga aattaagagt acagagtcgc tgaataagga cctcaaggat 840 gtggcaaaga cgcaggatga agtgctggat ggctgggtaa gcgttggtaa ggatgccgta 900 aatgccgtag gagacgccaa gaacacaaag gtggacacat ccggcgaaga aacaacggtt 960 acgaccctga caggtcagat cgacgcgacc caaaaagaac tggaaaagaa agatattacg 1020 gccgaagaaa aaacgaagct ggaacagcag cttaaacagc tgcagcagca ggaggcggac 1080 ctgaagacga taagcaatgc ggccgatgca acggtgaaag ccgcagacag ctctcaggcc 1140 aataaaatac tgaaggatta taatacggat tcctgcagca cggcaatttc cggcctgaca 1200 gaagaactga accgtgtgaa ggatatggat ctgagtgacc tgacccttga cgatgcagac 1260 aagatcacaa aacttcagga agggcttcat ctgaccgata tgagcaagct gtcggattcg 1320 gacaacttta attcgctgct gaaagaagca aatgatctga tcaataaggc ggattccaat 1380 gttacaagtt tctcgtccat tgcagaagca ctgagcacga tcatgtcttt gagtgcaagc 1440 tacgacccga aactgcaaag cgtgatcaat acggagtact acgatcagaa ttttgcaggc 1500 ctgccgagca agaaggaccg cagcaacagt gcttatacgc tggagtctcc gtatgaacag 1560 aaggatgcgg cattggcaca ggcagatcta gatgccattg attttgtaaa cgagatcatg 1620 gatctgacgg catggcaggg cggcgtttcg actgctgctt cggccgatac gtcgaaggcg 1680 gatgacgcaa aaaccaagat cggaaaactg ctcaattcga tgaagtccat gctcagcatg 1740 gtgacggctg gagccaatat tctttccaat ctgtcaaaca tcaaggcaga tatcggcgat 1800 catctgtatc tggttgggta tttgaactat accacaacga accgcacgga ctatgcctca 1860 aaaaagacaa tgtcgggcgt gagcataaaa ggctcaaatg gcctggcggc agaagtagca 1920 aagagcgaaa ataacctgac cgctattttt gacgcaaagg aggaaacgaa ttattcgttc 1980 tgtggtgccg agacggagta tcttctgatc ggaaatgaac atgaacggga aaatcagaag 2040 gcaatcttct acacgatgct ggccctgcgt gtggcgctgg actacaagcc ggtgacatcc 2100 aatgttgaag caagagcatt gagcgcgggc ctggctggtg cactgtccct gcttggcatt 2160 ccgtacaaaa tgacagatat gctggcaaaa gttttcctgg ttgcagcaga agcatatgtg 2220 gataccgtgc tgatctgtaa cggtgcacag gatattccct ttatcaaggc gtcggaggat 2280 attcattttt gcgcaaaagg cttgtcgaaa cttcccggaa agctgcaaaa actggttgcc 2340 atgacggatg accagaaaaa gacattgcag gaaaaggtga agcaggttga ggcaggcggc 2400 gttatcctgg gcggactgga gtcggacggc aaaggcgttg aagatctgcc caatctgaaa 2460 ggcagcaatg gcctttatgt gggagataac aagctatgca tgacctacag ccgaagtatg 2520 tttgttatga tgctgatctg gaacgaaaag gatctggtca aacgctttgc ggacctgatc 2580 gaaatggaag cgacccagaa gaatttggtc aatgatgcat cggtctctca gaagctgtct 2640 ggcatttacc ccaaatttga tttggataag tcctacacag cactgcgcat gaacgtaaaa 2700 ggcgattttg tgtcggtgct cccggtgcct tcgctctccc ggaattcggt ttggaaagca 2760 aatcgggtca tgtatagggg gtattga 2787 <210> 192 <211> 588 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(588) <223> ICBIDGAJ_00777 <400> 192 atgcagaaaa aaaagagaaa tctgttttac gcagaagagg gtgtaatggc gctggaagcg 60 tgcatttcat tgacactgtt tctgatcgcc atgatggcac tgtacagttt gatcaatatg 120 tttacggcac agagcatgat ctcacatgca ttgcagcaga cagggcagag cattgcactg 180 gaaaattata aaaattcaaa gacggacgta aaaacactgc aaaagcttcc gctgagtctg 240 ctgcaaaagt tcacagacgg cattggtgct tccagtgact caaagtatga tgtcggcgga 300 gggtccttct caaattcgat ggtttttacc gactatctgt ctttgagcac tgtgaaaaaa 360 aggtttgcat cttatctggg aggaaatacg gaaaacgcgg ataagatgct gcagaatatg 420 ggcgttgtgg atggattgaa cggcatcaag ataaaaagcg gaaagatcag cggaaatgat 480 gtcgtgatcg agatatccta caaagtccgg ctcatatttt acattgaaac gttccacttt 540 ggcgagttcg aaagtacaca aaaagtttgc tgccgcctct ggaagtaa 588 <210> 193 <211> 177 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(177) <223> ICBIDGAJ_01351 <400> 193 atgagccgcc tgcgggaatt tgccttaaaa atattgctga gaaaggagaa aggcatcatg 60 gcagtcatct atgcaaccct cattgtgaag ggtaagaaga ctctcgatca ggttccggca 120 ttgattcgga agcaggacga ggaaatcctg aaggacctcg aagtcgaggt cgaatga 177 <210> 194 <211> 1479 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1479) <223> ICBIDGAJ_02512 <400> 194 atggcatcgt ttgaattgcg agaacccaaa aagaagcctc gttattataa actcatcgca 60 aatgttctgg tgaacggcaa aattgaacgc cgttatggtc ggttcgattt tgaccccacc 120 gaactgaaaa acgctcgtgc gcgcaacgcc gctgcgaaag ctgccgctgc cgaatttgaa 180 cggctggaac aggaaaaggc cgataaagaa gccagcaacg ccggaaagac ctttgcagta 240 gtggcgcagg agtacataga atccaaaaag gcaagacttg ctccttctgc tcgcttagag 300 ggcgattatg acagccatcg taataaggcg aacacaacga ggggcaagga aaactacctt 360 cggaagattc agcaattccc tgagtttgca cagaagcccg ttgattccat caaaaaggtg 420 gattgtgatt gggttctgga acaaatcgaa attggcggcg cacggtgccg cacccatgct 480 gttatcaatc agcgtggtct ggagatgaaa aaggaatctt gtccgaagtt agctaaaaga 540 tgcgattgtg gagcaaaaac catcgaaaag gcatttcgca gcgaaacagt tgatattaaa 600 acagcagaac aggtggcgat tgcgctgggc tgtaaagtgg acgatgcttt tgatgtggaa 660 accattgcaa aacctatgac cagaaagagc atgagagaat acgctctgtt cattcgttct 720 acactggaat atgcggatga aaattacggt gtgaagaatc ccatgcacaa aattcctgca 780 ctgggaagcc ggagcaggtc ggtagacact attaagaagc accagatcaa gcagcttcag 840 gacaccttaa aggaaagttc catgttggaa caggtgatcg ttctgtccct gctcaattct 900 ggtgtgcgcc gtggcgaact ggctggactg acatggaaag atgtcaactt tgaagaatgc 960 acgatacata tttctaaatc gcttctggta ttcaaagatt ttgggtatca gttgacaacg 1020 accaaggaaa gcaacatccg ggatgtggac gttgcaccgg agtacatgga cttcctcaaa 1080 gaatattata agtattggaa gtcccagaaa aaattgatgg gagggagttg gcagaaaagt 1140 ctggataaga aaagcagcaa gtatgcaccc tcactccttg cccttcgggg gacggacttc 1200 gtgatctgca atgaccatgg gttccccatc aacccggaca gctatggcgc actggttcgc 1260 agaatcggac agcgggcagg cattgaaggg ctgcatcctc atatgttccg gcacactttt 1320 gtgagcatcc tcttgtccaa cccggagatc ggtgtggcga cagtagccgc agaagccgga 1380 cacgcacagc ccagtaccac ccttgcaatt tacacgcagg tctatgacaa acggcgcaaa 1440 gaaattcgca accagatgag caaggagctg tacgaatga 1479 <210> 195 <211> 309 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(309) <223> ICBIDGAJ_01352 <400> 195 atggaccagc ctattacgcg agccgagcat gaggagttca agcgtcggct cgaagaggaa 60 aatgcccgtc aggacagacg aatcgccttg ctggaggaaa gcgtaagcaa aatgggcgca 120 ctgtccactt cggtcgagaa gctggccctg agtatggaga gcatggtcag ggagcaggaa 180 aagcagggaa aacggctgga aactctggag agccgcgatg gagagctgtg gcgtaaggcc 240 gtcggctatg cagtaacggc catcatcggc gcttttctcg gctatgtgtt cacccaaatc 300 ggtttttag 309 <210> 196 <211> 339 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(339) <223> ICBIDGAJ_01357 <400> 196 atgtttgatt tgcgtgagca taaaggcctc attcaccgtt tggtttccga ggcaaacaaa 60 aatgatgcca actggcactg gtcactaaaa gctctcagca agaccaaagc cagcattttc 120 tggagctatc tggagtacga aggccataag ccgtgcttta cgattgaact tgtcgaggac 180 gacgatggct gcttgattta tgcgaaggat gagcacggag acacactcaa ctttgagata 240 gttgagtgtg taggtcttcc tcgcctgaac accccgattg atgaagccat caaaatgatg 300 gcctattcga ttattaacac cgcccatgag tgctactga 339 <210> 197 <211> 153 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(153) <223> ICBIDGAJ_01356 <400> 197 atgaaaggtg agtgcagtat gacagctctg gaagcctctc gtctgatcga ctggctgaaa 60 gctcacggtc atacggacga ggaagcgacg cagtgtatca agtgcattgc cggagtcctc 120 gacccgcaga ccgaggagcc taagaaacag taa 153 <210> 198 <211> 648 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(648) <223> ICBIDGAJ_01768 <400> 198 atgcagagtg gatgcagatg ggtatacacc ctgatggact gggaaaccgg cgaggtggtg 60 gccaagggca ccagcgtgga gctggtggag cagggatatt ttcccgatgt gaacaagctg 120 agcagcgttt ggaataatct ggaaaaatgc aagaacccca gcccgaagaa ctaccggtgg 180 aagatggagc ggaagagcac caaggacgac cgggtggaga gggccagggc agaaggcctg 240 agcgcggacg agcgggccga gacccggata gtgcgggtgt acagctgcta cggtgcggac 300 ggcaccctgc tgggcaaggg cacggcggca gagctgaagg acaagggatt gtttggcagc 360 gagggcacag tgcacgagtg ctaccgcaag cggggcggcg tgtacaagcc cggcggcgtt 420 acgcggatgg agatggagct gtgccagaaa cggatccggc accccatgaa gctgccggat 480 cagccggtga aggtgaagcg caagcccatt ggcggcgtgc tcgaccccag ccccctggcc 540 tacgacgtgc atgatctgat gatctacaac gagaaggccc gaaagatcgg aaagccggag 600 ctgacctacg gctactgggc ggaaaaagga aagcccgcca cgccttaa 648 <210> 199 <211> 147 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(147) <223> ICBIDGAJ_01769 <400> 199 atgactaacg aactgactgt ccggcagaaa tgtgcggatg ccatggcagc ggctaccgga 60 agaaacctct caccgctgcg gtctggctat gccagcgcct tgcagagctc ccctgatatg 120 ggagccaagg atcaaggagg acgataa 147 <210> 200 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> ICBIDGAJ_02457 <400> 200 atggacaaaa acaatataac ctctgtgaaa attcctgcgg gtgccttttg cggacacaac 60 tgttctgacg gatgtatcta ttggaaccct tatgaccgtg atagtaatgg ccgccagtac 120 tgttcgcatt atgatactta ctactatccg agagagcgcc aaggatgtct tagttatgaa 180 gactaa 186 <210> 201 <211> 225 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(225) <223> ICBIDGAJ_01760 <400> 201 atggatatgg cagaagcaaa gaaaaagact gagacgatcc ggttgttttc ggacggcgga 60 aagtacaagg gtgacctgtt cgtgagcgtg aacggtgtga actaccagct gcagcgcgga 120 aagaacattg aggtgccccc ggaggtggcg gaggtcatcc gccacagcca ggaacaggac 180 gaccagaccg ctgcccgcat ggaagagctg gcgaataagg cgtaa 225 <210> 202 <211> 624 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(624) <223> ICBIDGAJ_01765 <400> 202 atggccatgc tgggctcaac ctccatctgc gctgtggcga agaagtacgg cgtgccggaa 60 tcgacaatcc gcagctggat gagcgaggag gcaggccgca gtgatgcctt tgcaaaggcc 120 cggcaggaag ccgcgcggga gatcgccatc cgggcaagcc tgggggtgcg ggcacaggtg 180 acctttttgc agggccgggc cgctgagagc cagcgggcgg cgcagatcac ggagaggctg 240 caccggcgtt tggacgagga cacccgggcc cgggactttg ccgtgggcac tctgctgaag 300 gacgacccgg aggagttggc ggatgccacc gagaccggcc ttgtggtgta tgcaagcccg 360 ggcagctacg acaggcagct ggatgacacg gaacgcaggc ggctgaacgc cgaactggag 420 cggtacgagg gccgggtgat gagcgacaag aacgcggccg gtgtggccaa ggtgctgatg 480 gaagtggccg aaaaggctgc tgccatggcc ccggcggaga acaccgacag cgagagcggc 540 ccgccgatgg tggagatcgc ggcagccgga gacgcggacg gcaagcagga ggtggaagtg 600 gatggcggca cagaggatgc gtga 624 <210> 203 <211> 885 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(885) <223> ICBIDGAJ_01767 <400> 203 atgcgctgta actacatccg agagaaaaaa taccagtgcg gggatgacta catggcagtc 60 ggagtgttct ccatcatccc ccaggaacac cggggccggg gcaagaagcg gaaggaatcc 120 agcgaggggc agaaggcgaa gaacaaaatg gattccctgc gcaagcgcca gagaaaggcg 180 ctgacaaatt tcagtccggc gggaatgttc ctgaccggta catacgagga tccatttctg 240 ccggaggaca ttctggcctg ccggagagac gtggagaact acaagaggcg ggtgatggcg 300 gccacctgca agcggttcgg ggcaaggcgg gaggacatcc gcctgatgct ggtggcggtg 360 cgcaagggag aagcaggacg gctgcacatg cacggttttg cggaatgccc gggcctgacc 420 gcagcccagc gccgggagtg gcgggagatg ctggaggatc tgtggcggcg gcgtatcccc 480 ggctccaacg agtttgagcc gctgggaacc atgaacgtgg atcggatcga catgaaaaag 540 ctgctgggca agagcgggca gggcgaatac ggaacggtgg gctacctcta cggccacaag 600 gagcggctgt gggtggaaac agtcaacctg cgcccggcca ttgagcaggc ccccaacgat 660 ggcagatgga gccggaaaca gctgcgggcc gcctgcgggg aaaagcagaa cgatgcccag 720 tggtgggagc agcggtttcc cggctggaag atggaaaagt gcatcgtgct ggagcccggc 780 gggctgcatg agagcccgaa gcgggaagga accggctggg aacggctgga accgcaatgc 840 tatgtgatcc tgcgtcggcg ggaggctgcg attcttcgca cctga 885 <210> 204 <211> 1416 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1416) <223> ICBIDGAJ_00754 <400> 204 atgggaaaat accaagaaga cgcaaggctg ctgcttgagt acgttggcgg caaagagaac 60 atcgcggcag tttcgcactg tgtatccagg atgcgttttg tgctgaatga tcccgccaag 120 gcggacgttg tcaagatcga ggcactgaaa tccgccaagg gcactttcac ccaagcgggc 180 cagttccagg tcatcatcgg caatacggtc agcgacttct acaacgactt cattgcggta 240 tccggcattg acggtgtttc caaggatgcc gtcaagagcg cggctaagca gaaccagaac 300 gcattgcaga aggtcatgag cgtgcttgcg gagatttttg ccccgttgat tcccgccatc 360 atcaccggcg gtttgattct cggcttccgc aactgcattg acagcatcta cttttttaat 420 aacggcaccc agacgctgtg caacatcagt cagttctggt ccggcgttga cagcttcctg 480 tggctgattg gcgaagccat cttccatatg ctgccggtct gcatctgctg gtctgtcaca 540 aagaaaatgg gcacgaccca aagcctgggc atcgtcctcg gcctgacgct cgtctctggc 600 cagctgctca acgcttacgc cgtggcttct actgcggcgg cagatatccc gaaatgggat 660 ttcggtttct tcaccgtgaa catgatcggc tatcaggcac aggtgatccc ggcaatcctt 720 gcagccttca cgctggtgta cttggaacgc ttcttccgca agatctgccc gccggtcatc 780 tcgatgatcg tggtgccctt ctgctcgctg gtgctgtccg tcatcatcgc ccacactgtc 840 cttggcccca tcggctggaa gatcggcacc ttcatttctg acatcgtcta cgccggcatt 900 tccggctcct tccgcgtggt ctttggcgca atcttcggtt ttgtttatgc cccgctggtc 960 atcaccggcc tgcatcacat gtccaacgcc atcgatatgc agctgatcgc cgacttcggc 1020 ggtacgatgc tgtggccgat gatcgccctt tccaacattg cacagggctc cgccgtgctg 1080 ggcatgatct acctgcagcg caagaatgct gccgcacagg aagtcaacgt tccctcctgc 1140 atctcctgct atctgggcgt taccgagcct gccatgttcg gtgtcaacct gaaattccac 1200 ttcccgttta tttgcggcat gattggatct gccatcgcag cggtcgtctg tgtggcaact 1260 tccaccacgg ccaacgccat cggtgtcggc ggcatccctg gtattttgtc aatccagccc 1320 gcctatatgc tcagctttgc gctgtgcatg gccattgcca tcgtcgtccc ctttgtgctg 1380 accgtcatcg tcggcaggaa aaaaggcgtt gcctga 1416 <210> 205 <211> 1626 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1626) <223> ICBIDGAJ_00755 <400> 205 atgaatgatt ttaaagataa agttgtctac caaatttacc cgaaatcctt catggactcg 60 aacggtgacg gcttcggcga tttgaagggc gtcaccgcga aactggacta cctcgccgac 120 ctgggcgttg actatctctg gctgacgccg ttcttcccct cgccccagcg cgacaacggc 180 tatgatgtgg ccgactaccg tgccgttgac ccgcgttacg gcacgatgga ggagctggag 240 gagcttatcc gcgaggcgga caggcgcggc atcggcctga tgctggacat ggtgttcaac 300 cacacctcca ccgagcatga gtggttcaaa aaagcactgg cgggcgacaa aaagtaccag 360 gactattaca tcttcaagga cggcacgccc gactgctgcc cgacgaactg ggtgtcgaaa 420 ttcggcggcc ctgcgtggga atatgtacca tggctcggca agtggtatct gcacctgtac 480 gatgtgatgc aagccgacct gaactgggag aaccccgccg tgcgggagga aatggccgac 540 atcctgcgat tctggaaggc gaagggcatc aagggtttcc gtttcgacgt catcaacgtc 600 atttccaagc ccaaatttta cgagaatgac tacgagggcg acggccgccg cttctacacc 660 gatggccgca acgtccacaa gtacctgaag gagctggtcg ccgcgggcgg catcgacggc 720 atgatcacgg tgggggagat gtcctccacc acgctggaaa actgcatcgg ctacaccgct 780 gagggcaatc acgagctgac gatgtgcttc aatttccacc acctgaaggt cgactacaag 840 gacgggcaaa agtgggaatt gagggagcct gattacctcg ccatgaagaa actgttccag 900 acctggcagg aggggatgca ggcccacggc ggctggaatg cgctgttctg gtgcaaccac 960 gaccagcccc gtgcggtcag ccgctttggc agcgacacga cctactggga ggaaagcgcc 1020 gagatgctgg cggtggccat ccactttatg cgcggcacac cgtacattta tcagggtgag 1080 gagctgggca tgacgaaccc gcacttcacg aaaatcgagc agtaccgcga catcgagagc 1140 cgcaactact acaggatcct gcgagagcag gacaagacag aggccgagac gctggacatt 1200 atcgcccagc gcagccgcga cgacagccgc accccgatgc agtgggacgc gagcgagaac 1260 gccggtttta ccaccggtac gccgtggatc ggcattgccg acaactacaa ggccatcaac 1320 gccgctgccc aaatggacgc cccggattcc atccgcagct tttacaaaac gctggtggcc 1380 ctgcgcaaga aaatgccggt catcagtgcg ggaaaaatcg agttcttgta ccccgacaac 1440 gcggatttgt tagcctatcg ccggtacgac ggcgagacgg agctgctggt tctctgcaac 1500 ctgcgggagc gggaaattgc caagcccctg cccgtaggct ggaccgatgc cgagaaactg 1560 ctgggtaact accccgacac cgccgacacg ctgcgcccct atgagtgcgt agtgctgaaa 1620 aagtga 1626 <210> 206 <211> 723 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(723) <223> ICBIDGAJ_00753 <400> 206 atgccaaaag caaaatatga aggaatttac cgcagtatca aaaaacggat cgaagcgcag 60 gactatcctt accagtccct gcttcccagt gaaaatacgc tgattgcaga atacgactgc 120 tcccgcaaca cggtgcgccg tgcaattgcg gaactgatcg ccgacggcta tgtgcagtcc 180 atgcagggac ggggcgttcg ggtcatctac cagccggtgg gaaagacgac ctttaccatc 240 ggtggaatcg agacgtttca agaaaccgcc cgccgcaatc gtctgcaagc cgttacccgc 300 gtcattcggt ttgagaccat catcgcaacg gagcagtttg ccgaggaaag cggattttct 360 gagggcgatg aattgtgggc ggtacagcgt gtgcgttatc tggacggaaa agcactgatt 420 ctggacatca actacttttt aaaggaattt gtacccggac tgacagagga aatcgcatcc 480 cattccatct atgattttat tgaaaacgtg cttggaatgc agatcatcac cagcaaacgg 540 cgcatcacgg tggaacacgc aactgcccgt gatgaaaagc tgctggatat ggacggctat 600 gattgcgtgg ccgtcgtcgt gaaccagact ttcaactcgg acgggatgct gttcgagtac 660 acccagtccc gccaccaacc ggactatttc tcctttcagg acattgccac gcggaaaaag 720 tga 723 <210> 207 <211> 921 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(921) <223> ICBIDGAJ_01856 <400> 207 atggaagaaa taactgtatt gatgtcaact tataacggcg aaaaatatct acgggaacag 60 ttggacagta tttttttgca aaaaaatgta aaattgaagc tactcgttag agatgatggc 120 tcaacagata acacaatgca gattctgcaa gagtatcgac agaaatattc tgatttggaa 180 atttggacgg atggaaaaaa tcttaagcca tgcaagtctt ttttctatct aattcagaat 240 gcaccagaaa cggaatatta tgctttggca gatcaagatg atatttggga ttgcgataaa 300 ttggaaacag caattgatcg actgaaaaga tactcgcaag agatcccggc actctactat 360 agcaacctta gaattgtaga tgaaaaggat gtcttttatc gaaattcgca tgaaatgcct 420 gcaatatgta gaaataaata cgaatatctc acagacatga aggctacggg ctgtacaatt 480 gtctacaata gagcattggc agaattaata cataacagaa tcccggatga attcaccatg 540 cacgatgcat ttctttatat tattgcgtca atattcggaa atgtgattta tgactttgaa 600 ccgcatatag attatcgtca gcatggagac aattccattg gtacatacct tgacaagaag 660 cctgttacag catatttcaa gcatatgggg agactccttg acagaaatcg gcaaccaaga 720 cgaaaaaatg ctgatgcagt attgtcgaag tatggtgaat tcctgcaaaa tacacatccg 780 agagagtatg aaaaattaat ggaactttcg acctataaaa atagcttgaa acaaacagta 840 caactactga aggataagga actttatcca tcttctggaa tgtttcgcta cagcgtgtta 900 gcaattttgg gactgctgta a 921 <210> 208 <211> 567 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(567) <223> BLCPAMOF_00067 <400> 208 atggattcca agggcgaagc aattaccgtt aatatttttg atgctataaa ggaattctac 60 ggcttgacac ttgttgatct tgcagttctt tttagggaaa actttggcgt gatgtattat 120 gcgcgtaatg tgcgtattac ggacaggcgt gcatatcagt ttgcaagtac acttcgtctt 180 ccagtggaat tgttcaaaaa tacaactaca gatgattttg atcaaattga atttggcaag 240 aaactctttc ttaaaaataa tgacatagaa gaaatccgta atgcaatgcc ggattggaaa 300 gcacgattgg caaaaatgtt ggcacagctc tatttgagat gcccgatgga cacggcaaaa 360 gaactatcca gaatggatcg cttttattgg agcaggggcg ataatatgga tcggctgaat 420 gcaaccgaac ggctgtttgt ttctacagcg gaaaaacgga ttagaaatga gtcgcattca 480 attctattgg gagtaagtta ttttttggat aacaaaacgg catcacattt taatctacga 540 caaagtcgta gtggaagata tgattga 567 <210> 209 <211> 438 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(438) <223> BLCPAMOF_00066 <400> 209 atgaaaattc taggagtgct tcttgcgttt gtcggttttg cgcttggaat atatgaaata 60 atcaatacgc ttagaggaaa agaaaataaa aggatattgt gtggcgtagc gatagcatat 120 cttggctacg gtgtgtgcta ttcagtgtct caaaaagatt tggggtatct tggtgttgca 180 tttttatttg ggttgatttt ttatgcaata agagttatgt gcgttctctt gaggatggct 240 gctaagcgtg aaaaacgcag tcttaagaat gatttgatag tgctggctgt tctgttggta 300 ggttttattg ccggaatgat gcttccatat gataaggaag aagaagctaa aagaactgca 360 gaatcagtcg ctagtgtgat ggaaaaagcg gcacttccgc ttgcaggcct tgattataca 420 ctggatgatg tgaattga 438 <210> 210 <211> 444 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(444) <223> BLCPAMOF_00069 <400> 210 atggacaaca accaactaca gtacatcaaa attcaatcgc aatacgctga taaggtagaa 60 caatttgaaa agtgcgttgt caaagccgca aagctgacac acgcgattgc tgacacggct 120 gagaaaaaat gcaagcaggc gcggatggca atggaatctg gcaacataga tgtcatgcgg 180 aatacgattc agcagtacat ctgccagtac ggacgggatt ggtcacgttt ccgggatgtt 240 cggatacagc ttgtagatgg gaacacctat gcacagctct ctgccgttga tcttatccag 300 cagctacatt gtgttatcac gctggtgtac aaggatactg cgttgaaaac ggtgaacaaa 360 gaagtattcc gagagtgcgt taaaagtttg ctgaagcagt ccaaaatgtt taccgataaa 420 gagctagatg caatgtttgc gtaa 444 <210> 211 <211> 612 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(612) <223> BLCPAMOF_01414 <400> 211 atgatgacgt ccgagcagat acagcagctt cggcgcgatg agactgcgat gatggcagaa 60 tggtcggcgt cctctgtgca gccgtgccgc tttaacaccg acggcatcgt ggactatgag 120 cgctgggcgg cactcccggg cggaaagcat atcgttgttc tattgaagga aacgaatgct 180 ctgagcggaa gccttgtgga ttttctttct catggcggaa gcaaaactta ctaccggacg 240 tggaataatg tcgcacgctg gataaatatg gttttgaatg gaacatattg ggaattcgtg 300 ccaaaatcag ctctggatga tatggttagg aatatcgctg tgataaacct caaaaagtgt 360 tccggcagcg cccatgcaag cacaaaggcg gtacggcagg ccgcccggca ggatgcggac 420 cgactgaaac gtcagataca gctctacgaa ccggacatca tcctgaccgg cggctggggg 480 ctggtatcga acattctgca cgatgagata cttgcggatg acgccgagtg ggtcaagccc 540 aatggacaga cagcattatg gtattacacg agctgttcag tccgttcgga aaaagaaaca 600 ctctcgttgt ga 612 <210> 212 <211> 861 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(861) <223> BLCPAMOF_00555 <400> 212 atgaagacct cttataatga agcctgcgcc cgcgactgct ctactctgga aaaagatctc 60 gccctctgcg agaaagctgg cttcgattac atcgaaatac gacttgatct gctccgaggc 120 tggctcaagg accacacggt agagcagctc aaggaatttt tcgaaacgca tcggctcaag 180 ccccacgcca ctaacgccgt ctacctgcat catgggatgc tgccggacga aacgcccgac 240 tgggatgacc ccgccatgca ggacttcaag ctggcctgtg aggtgggcag cgccatcggc 300 agcggctacg tcatcatcgt gccgcccctc gaccccagcg gggtgttcac cggtgatgta 360 gccgccgcag agcaggagtg catccgcatc ctgaaaaaac tctcggcgct ggcccggccc 420 tacggcatga agctctgctt cgagctggtt ggcctgcgca agagctgtgt gcgcagcatc 480 gaggccgccg accgcatcgt gcgggccgtg ggcgaggaca acgcaggctt cgtgttcgac 540 tcctacaaca tctacctcaa cggccgctgc aacgatttca gcgccatcaa aaacgtgcag 600 cccgaaaaaa tctttgccat ccacctgatg agcgccgacg acgtccccga aagcgagatg 660 gggcaggaca agcgctgctt tgccggcacc ggcgccgtga acaccgacag ctttttgcag 720 accctgaaat gctgcggcta cgacggcatg gtctcggtgg agaccttccg ccccgaatac 780 tgggccaaga cccctgagtg ggtcattgag aatgcctatc gtacgaccta tgccgcactg 840 gaaaagaacc agtgcctcta a 861 <210> 213 <211> 132 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(132) <223> BLCPAMOF_01552 <400> 213 atgagcaaca aggaaaaact gaccgagcgc tgggcgcagg ggcgtatctc tgaggcaatg 60 ctgcgggtgt atgtccgcaa gggcatcatc accaaggcgg atttcgagga gatctgcggg 120 aagaagtatt ga 132 <210> 214 <211> 369 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(369) <223> BLCPAMOF_01553 <400> 214 atggcacgat acaaaattta cgacaacaaa tctgacgtca tcaccccggt gggcgagaag 60 cttaccgctg agcagtggct ggaccgttac cagtggggcc gctacaccaa gatgatcgtg 120 ggcggcggca tcatcaacgg cagcgtcgcg ctggtcttcg acgatgaggt ggagcgttac 180 cgcaaggcag gctgcgattt cagtgcctgc accaccgacg aggactatct ggccgccatc 240 gaggcctttg aggataaccc gcccgtggca gacgccggcg tctccgacca gacccgcatt 300 gcggacgctc tggaagacat ggtggcgctg agcctgccgg atgataccac caacaccacc 360 gaggaatga 369 <210> 215 <211> 1125 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1125) <223> BLCPAMOF_01554 <400> 215 atggcaaaag cagtttatgt gggagtcgga agcaaagccc acaagatgaa gaaagcctac 60 atcggcatcg gcggtaaggc ccgcaaggtt aagaagatgt acatcggtgt cggaggcaag 120 gcgaggctgt gctacagtgc agagctggaa aaggtcggga tggctacggc gctgagcact 180 acacggtatg atatgcgggc cgcgaccgtc ggcaaatacg ctttgtttgc gggtggatat 240 atctccaagt cctcttttgg ctacagcgtc agcagttccg tggatgccta caatacctcc 300 cttacgaaga gcacaccgac agagctgagc tacaaacggt gcggtcatgc ggcggcatct 360 gtcggcggct atgcgctgtt tgctggcggc gcatcgtcat ataatctatt gggcttttat 420 gaaaatctcg tgagcgctgt ggatgcatac gatgcctctc tgacccgcag tgccgcccac 480 ataataggcg ccacagtcgc gatcggaggt gcagccgtcg gaaactacgc gctgttcgca 540 ggtgggacgg tctacagtca aataaatgaa gataacgtga cgagcgatgt gctggcgtac 600 gatccctcac tcaccttcac gacagcacct tggttgagtg ttgcacgagc gaatgtgaaa 660 ggcgcaagcg caggcaatta cgcactgttc gctggcggaa gagccggtag tttttgtacg 720 acagtggacg cctacaatgc ttcgctcacc cgcaccaccg cgaccgctct gagcagcacg 780 aaaaacaaca gcgccgctgc aactgtcggg aaccacgcaa tatttgtggg caacactgcc 840 tccgcagaca tctacgatgc ctccctcacc aaaacgtctg ccgccatcct gagcacggcg 900 cggacgggtc tggctgcgac gacggtcgga gactacgcca tcttttcagg aggtggagtg 960 gcagatttct gcgacgcctc tctgacccgg agcagcatcg gcaccagcat gacgggctat 1020 gacatgggtg ctgcgaccat cggggactac gctttgtttg caggcgggca atccggtgaa 1080 aacagtggca ccgcttacga ttccgtcgaa gtctacaccg cataa 1125 <210> 216 <211> 729 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(729) <223> BLCPAMOF_01093 <400> 216 atgataccta caagaaagac cgatgaaaaa ttttatcggc tgttttcgac ctttcacgcc 60 ttttcagagc atctgaccaa gcgggaagac aatgaactgc gcgataaata cgaccacaat 120 gcgttctgtt attccggcca gcccacggag gacgagctcc gggccgcgct ggcttatcag 180 aaagcgcggg gagacgcctt cctcaaactg gaaggatacg agccgctggc caatgcattc 240 ggcatggagt gcgaggagac tgtgacgatg gttctgccga agggaacaga catcagcggc 300 tggaaagcga atccggaggt ctcgatcaaa accccggact ttgaccaact agaacagcac 360 gagctgaaat actacgggcc gttgtacgga gaagatttca ccgtgcggaa caaccggcat 420 ctccgggaaa aactgaccta ccttggagcg tatctgggcg ggaaactggc gggcgactgc 480 tatattttcg catccgatgg atacgtctgc atggacagtc ttttggtgga tgaagctttc 540 cgtcatcaat acatcgccac gaccctggtg aagcacattg ccgaaaaggc acaggaacgc 600 ggggctgttc tgtatcttca tgccgacccc gaggacaccc cgaaggatat gtatgcaaag 660 atgggatttc aggctgtcga taagctctat gaatatctct gcacagattt ttcaaaggtg 720 aaaatataa 729 <210> 217 <211> 213 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(213) <223> BLCPAMOF_00662 <400> 217 atgaaaaaaa caaaacagaa atggtgcctg cgcatcctgg tctggctggt ggctctgctg 60 gtccttctgg gggtggcaga ctcctgtcgt gttcaggaag accctcaccg cacactggta 120 cagggcagac tgcaggaact gaacgacagc tggacgctgg aaacagatca gcaggccgtg 180 tatgacattc cggaaagcat ggggaaagcc tga 213 <210> 218 <211> 1425 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1425) <223> BLCPAMOF_01558 <400> 218 atgaagtgcc tgtttgtgac gctcatgtgg aatgcccggg ccgaaatgcc cgtgccgggc 60 gatatttttg cggtctgctg tcagtcttac agcccgaatg gaatgacgcg gtacagacgc 120 tacacccatc tggacgacat gagcgccctg acgcagtgga caaaagatgc tgtttaccac 180 aacatcacgg tactggaaac agcaaagccg cgaaaagaga ttttgaatac ggtagcggag 240 accttcccgg cctatgacgt tctggtcctg tggagccgga aagaatatga gctgttccgg 300 caggcgatgt atgactgcgg acatcgcctc tgtacggcga aagccgttct gctggaagaa 360 ctgctgggag cagtcgtccg ccccggaaag aggggccggg tgccttttca gcaggtgctg 420 agggcgtttc atgtccagac gacccgggag acgttttacc agccgaaata ccgggcgggc 480 tttctgcttg agctgtggga cagggtgagc cagcttgcgg cgcagagcga ggagtggacg 540 cagacagaac tctgccttaa ccccaggaca aacaccgtcc acctgccggg atgcagtcat 600 ctcggcctga cgggcggaca gccctgtacg ccgcaggtgc ttctggaagg ggctgccctc 660 tgcagagact gccaaaagaa gaaggcgctt tatctctggg agatggagcg gctgcacgca 720 gtgaagttcc agcctcacgc aggtgctctg gggacgccgc aggattatcc gccggcaccg 780 aagctgttct accgggaggg cgacccgcaa aagctttacc atgaccgtgc ctgcccctgc 840 tgcaaaccgt tccgggaggg gccggactat ctgcagtgga agccgctttt cgggagagcc 900 gatgcggaag ccctcggcct gacggcctgc gaccggtgtt caccgctggg catccggtat 960 gggcagaccc ggacgcagat agagtccttc tgcagccaga gagggatgca gtgtgtgctg 1020 cgggatggcg agatcgacgt cacaacgtcc atcggcgggt ggcggctcgt ctggaaggga 1080 aaagataaga tctggctcta tcacaagaac acccatagga gccatctgac tgagagtgag 1140 gacatccccg gctatcacag tcaggccatt cacaagaaga ccatcatgga gtatttggaa 1200 tacatcgtcc agcacgatct ctaccggaaa aacagtccgc tcccggagac ggggagtgtc 1260 cctgccgcaa aaccgccgga gccgacccat cggggacacg gccatcaccg ggacgcaaag 1320 ggggcaaagc atttccaaaa gcacaagacg aacaaggtga aggtgagctc actggaacaa 1380 ctgcaggcgc tggcccggca gaaaatgacc ggagaagagg aataa 1425 <210> 219 <211> 132 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(132) <223> BLCPAMOF_01622 <400> 219 atgaaaaaat ttttgatggt actgttgagc attgcatttg tgatgaatcc tgtagaatcg 60 aatcccgcta gattccggct gcggagtcca acgggattct ttttgcccca aacgaaagat 120 aaggctcact ga 132 <210> 220 <211> 150 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(150) <223> BLCPAMOF_01623 <400> 220 atgacagaaa acttgtgccg gaaaagtatt aaaaatgccg tagaggtaaa agagtatcaa 60 attctctatc atttgagaga gttgcgtcag caaatcggca acgctaaaat gacgaacggc 120 atttttgata cagaaagaaa agagttatga 150 <210> 221 <211> 111 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(111) <223> BLCPAMOF_01620 <400> 221 atgaatgata tttacgcata cgaccccgat acagaggaag aagcgggcca atgcatggat 60 gaagtgattc agattgcaga ggaaagcggc gccgaaattc agttctacta a 111 <210> 222 <211> 1413 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1413) <223> BLCPAMOF_01018 <400> 222 atgaaaaaga agtaccaaat atttatttca tccacgtata aggacttagt gaaagctcgt 60 gcaaaggttc gtgatgccat tctgtctatg atgcactttc ctgtgggaat ggaaatgttt 120 aatgctgccg atgaagagca atgggagata attaaggaaa ctattgatag ttcggactat 180 tatgtattga ttttagggca gagatacgga tctgagattg aagaaggctc agatgcagga 240 atcagttata cagaaaaaga attcaggtat gcgactgaaa agaagattcc gattctagtc 300 tttattatgg ctgatagtgt tccgttgcaa cgagacttca tagaatcgga tagtcaacgg 360 aaaaagttgg aaaaattcaa agtaatcgca agtcacggtc atacgatgca gtggtgggag 420 aatgaagatg agttggcgag aaaagtaata gcatcgttgc atcaacagat ggataggaaa 480 gaacgaaccg gatggattcg aggcgacagt tttgatattg aggcaagcta cgcagagtta 540 ttaaaattga acaagaaaat ctgtgagtta gaagaagaaa acgaaaaact caagtcacag 600 attgtcgtaa gaaagccaca tttgaaagtt tcttttgtaa tggcagaagt agactcagca 660 gaagagagca agaaggagga gtgttatttg cacggaggcc tggtgcaaga aataagtgag 720 aatcatataa agatgcggga aattactggc aatgcggaaa attatagaaa taaatacgag 780 ccactggaaa taggttatgt ggatgcgcat ttgaggccgt atgttaggaa agaagatata 840 caaaagtata acgagtcact acctgatgcc aaagcgatag atgaatatat taaacaaatg 900 agggtgtatg agaaactaaa aaagggcggg gttgcacttt atttgaaaat agaaaatgat 960 ggtacggcca aggcaacgga cgttagagtt agtgcaacat ttccagagtg tgttcatttg 1020 atgaatattg atgatgtgaa aaaattagtt gaaccaccag caccgaagct tcccccaaac 1080 ccgattgatg cggcagaaaa aaaatatgaa agaaagatga atcccatggt ggatttggcc 1140 aattattttg catgtgtgca gccaagctat tcatttgatg cgataaattc ctcgtttctt 1200 agcaataggc tagacacaaa agattactgt ttctatattg atgaaaacag tatattcgca 1260 gaaaatagac aactccccca caaagatgca ggaatttttg acgattttta tatgatccct 1320 gtaaagaaag gtgatgctaa aattaaaata tctatgatgt gttcggaata tgttgaacca 1380 gaagagcaat atatcgacat tcaaattgtg tga 1413 <210> 223 <211> 849 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(849) <223> BLCPAMOF_01014 <400> 223 atgattacgg gatattttta tggagatact gttgcacggc ataaggaagg gcgacagatc 60 aagaaaatac tctacatggt tgtagaggca aatatacttt actttgtctg gaatattgca 120 attgaggttc ttagaagaaa tagcataata tcttatgtgc aatcaatttt ttctataaaa 180 aacttactga aatttttgct ccttaatgat tcaccgttgg catggcatct ttggtattta 240 agcgcagtct tttatgtgct tgtaattgtt ttactggtgg ataaactcaa ctgccggaaa 300 gatttgtact atttgacccc gattttgatt atcgtagatt tggtgttcgg aaagtattca 360 ctgctcattt tccatcggga gttcccgtac atactggtaa gaaatttcct ttgtgtagga 420 ataccgtatt tttgtattgg aaatcttatc agagaaaaac agtgcgctga aaaatggaat 480 aaaacagtac ttcagttatt gattgttatt tttgtgataa caagtcttgc agagagattt 540 gctttggtga atgctggact gaatgcaaca agagatcatt atctcagtac gacttttttg 600 gcaatctgcc tctttgtata caccctcaag agtaattggc ataataaaga attagctgtg 660 attggaagaa aatattctac atggctttat attattcatc cgatttttat tgcatttttt 720 tcaatggtaa ctggtaaact cggcataaaa tcaatttaca gttatgttgc accgattgtg 780 gtttattgtg caacattaat atttttgatt gttatgcata gacttaaatg gcttttagta 840 aaaaaataa 849 <210> 224 <211> 1653 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1653) <223> BLCPAMOF_00304 <400> 224 atgcggaatc gactggaacg gaggcggctg acactgcgcg ccgcagcact gtgcatcgtg 60 ctggtgctgc tgtgcggctg tctgctgccc gcatttgccg aagggccgga gcggacggac 120 agcatgccgg accagacatg ggacgaggaa atagaggacg agcctgcctg ggacgaagaa 180 gaggacatcc ggacagacga gccggtgctc ctgcccgcag aaggcggcat ccccgccgtg 240 gtggacgggc tggatgacat cgggctgccc gacgagacgc cgactccgga cagcgggact 300 gtcaaagcgg acgagcattt tgagatgaca tacctcttct ggctcagcga gtcggatgag 360 gccgacggcg gcctgcccta cgcggaacag accgtgggca gcggcgaaga gcttctgatg 420 cccgaagagc cggaggtgga gggaaagagc ttccgcttct ggtacagccg ggacgacgaa 480 gggacggcgg tccgcttcgt gccggatgaa ggactgctct ggccggaagc ggacagcgag 540 tgcagcctct acgcctgttt catcgacgat gaggcccagc aggaggagcc tgtttcagac 600 gaggaagaag gcattgccgt tctgccggag ctgtcggaag aacggcccgt tgccgaggag 660 gaaacgtctc tggatgaggc agagcagccc gaagaagaca gatcccctga ggaagatgcc 720 gacttggccg acgacaacgt agccgaggat aaaaccgccc ttcccgcgga cgaacttgat 780 gaggatgcac cgggctgggg ggatcggact caggaagagt cggcggcggt cttcctgctc 840 aagaccccca ccagcctgcc cggcagcaat gaccccagcc agtgggcgcc ggacaacagc 900 gagtgcaagt gggtcggtaa ggtgaagacc tacggcgcgg catgggaaga taacggcaag 960 aacatcctga cagatgtgtc agactatgtt gtatcgtggc cgggcggcgc gactggcgac 1020 gcatggtcgc tgaaaccggg cgatgactac tgggacgagg tcgtcgatga gatatgggac 1080 gagtataagg acaccatcga gaagcagacc ggcatcacgg ggctgacgca ggacgatctg 1140 gagagcatcg ttgtgacgcc gtacaagatc tcgcgcaaga acgggacaaa accggataag 1200 cacatcgact gcatcatcag cgtcaaaagc aggaaaaact tcacggcccg gttcaacgtc 1260 cgcgccccgg gcgaggacga ctacagcatc cgggaaagcc gcgagtacca gagcggcgag 1320 cgggtggaag ggacgacggc ggacatcgaa aaagagctcg acatcggcgg tgcgcgctat 1380 gtctttgacg gctggtacaa agagctcccc ggttcggtga cggatgagcc ggacccgaag 1440 gaaaaggtat cgcaggacga gtgggaagag ggctatgagc ccaccgacga agagctggaa 1500 aacggcgtcg tcaatttcta tgcccactac gttctggccg atatagaccc ggacaccggc 1560 gtggagacag acttcttcgg gctgccgctg gtgctgtgtg ccggtgcggc cgttctgggc 1620 tgcaaaaaca gaaagaagga ggaagatgag tga 1653 <210> 225 <211> 699 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(699) <223> BLCPAMOF_01951 <400> 225 atgtccatgc tcattgaagt atggggcgac tatgcctgtt tcactcgtcc ggaaatgaag 60 accgagcgtg tgagctacga catgatcact ccatccgctg cgcggggcct tgtggaagcc 120 atctactggc accccgggct gcgttatacg gttgaccgca tctatctgct caagcccttc 180 ggccttgacc ccgaggatga agcgtccacc gaggaataca cccagcggcc catccggttc 240 accaacatcc ggcgcaacga ggtcaagtcc accctgctgt cctccgccgc cctcagtgcg 300 gccaaaggcg gcacaccgcc ggtgctctac acctcggagg acatccagca gcgggccgcg 360 atggtcctgc aggacgtcca ctacgtcatc gagtgtcact ttgatttgac ggacaaggct 420 gcccccagcg acaatcccgg caagttccag gacatcctgc gccgacgcct gcgcaaaggt 480 cagtgctatc accagccctg tttcgggtgc cgggagttcc cggccaactt ccgggagtgg 540 ccgggcggca gcattccggc gctgaaggtc acgcaggacc tcggcttcat gctccacagc 600 ctcgattact ctgattcggc caacatccgc agccagttct tccgcgcaaa gctggtggac 660 ggcgtgatgg aatgccggga cgtggaggtg tttacatga 699 <210> 226 <211> 1764 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1764) <223> BLCPAMOF_01952 <400> 226 atgatactcc aagcactcac cgcctattat gaacagctct tgaagcaggg caaggtggag 60 gcccccggct gggatagtaa gttcaaagtc agctatgaac tgcgcctcgg ccccgacggc 120 cagctcctcg ccctcaacga cctgcggcag gaagtcccca agggcaaaaa gaccgtcatc 180 tccccccgtg agctccctgt cccccaccgg gtcaagcgtg cctccggcgt cgccgcaaac 240 tttttgtgcg acaatacgtc ctatctgctg ggcgcagatg aaaagggcaa gcccgagcgc 300 tcccgccagt gcttcgaagc ctgtgccgcc cttcaccaca aggttctcga cggcgtggat 360 tcccctgccg ccaaagccat cctcgccttt tttgacagct gggagccgga tacagccccc 420 acccacccgc tgctggcaga gcagtgggcc gacctgaaca acaacgcgaa ccttgtgttc 480 ggctacgaat cccccgacgg cgcccactgg ctggccacca cagatgacgc catccgggcc 540 gcatggcagt ccgcctttga cacctccgat gccgacgccg agacggcccg ctgcctcatc 600 accggcaaag aggccggcat cgcccgcatc caccccgcca tcaagggtgt gatgggcgca 660 caggccgccg gtgcggcgct ggtctccttc aacgcacccg ctttctgctc ctatggccat 720 gaacagggtg ccaacgcccc cgtcagcgag tacgcggcct tcgcctacac cacggccctc 780 aatctgctgc tggcagaccg gaactgctgt cagcgcatcg gcgacaccac catcgtctgc 840 tgggccgaaa acgccgctcc cgcctactca aacgccatgc tgatgttttt ctgcggcggt 900 gccgaggcgc gcggcgtctc ggaaagcgac cttgccgccg cactgaaagc cctttctcaa 960 ggacgccctg tctccttcct cgatgacaag ctggacccga accagaactt ctatgtgctg 1020 ggcatctcac ccaacgcggc ccggctctcc gtccgtttct tcctgcgcaa cagcttcgga 1080 cagtttgcca aaaatctgca ggaccacgcc gaccggctca gcatcacccg ccccgccttc 1140 gacaagcggg aaagcctgtc ggtctgggcg ctggcgcagg agacggtcaa ccagagatcc 1200 cgggacaaaa atccatcgcc tcagctggtg ggcgatctgc tccgggccat cctcaccggc 1260 gggccgtacc ccgccactct gctcaacggc gtgaccctcc gcatccgggc cgaacgggaa 1320 gtcacccgag gccgcgccgc catcctgaaa gcctactatc tccgcaacta ccccaccgag 1380 ctcaacaagg aggtatttac cgtgagcctg aacgaaagca gcaatgtccc ctatgttctg 1440 gggcgtctct tctctgtgct ggagacgatc cagagcgtcg ccaaccccgg catcaacacc 1500 accatcaaag accggtactt caactcggcc tgtgccaccc cggcaacggc cttccctacg 1560 ctggtcaagc tggctcagaa gcatctgcag aagatgagca cccccaacga ggtgcatttc 1620 agcaaacagc tcaccgagct gatggcccag ctgcccgaga caggcttccc ggcgcggctc 1680 agcctgccgg agcagggtgc ctttgagata ggctactacc accagaccca gaaacgctac 1740 gccaaaaaga atgaggagga ataa 1764 <210> 227 <211> 141 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(141) <223> BLCPAMOF_01796 <400> 227 atggtatatt ctatccagag agatgaaggt gctcaggcac tggaaaatca cttgaatgta 60 attgactcaa aaaagagttt gcgaatagaa tatttagcaa agcagttgaa aagctgtgac 120 gcaaagctaa agggcctgta a 141 <210> 228 <211> 444 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(444) <223> BLCPAMOF_00719 <400> 228 atgatcggtt tggtagttac cggccacggc cattttgcag acggtatcca cacctctgcg 60 cagatgatcg cgggcgaaaa tgattatgtc cgctacatca actttgaaga ggggatgact 120 cccgagcagc tggccgagaa gttcaacgcc gcttttgacg agttcaagag ctgcgacggc 180 gtcgtggtgc tgtccgacct gcccggcggc tctcccttca agactgctgt ggagtgcaag 240 tatgcacgcc cggagcagaa gatcgaagtc atcgcaggca ccaacctgcc catgatcgtc 300 accgccgtga ccatgctgga catggaggac gatccccgct cgctggcaga cgagcttatc 360 gacaccggca gggactgcat cgctctgttt gagctggagg ctgccactgc cgagaccgaa 420 tctgaagaaa gcgacgggat ctga 444 <210> 229 <211> 1179 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1179) <223> BLCPAMOF_00718 <400> 229 atgagcattt ttaatctgac cgatgagaag atgaaggaga cgtcttccac ctttacggcc 60 catgagatct atcagcagcc tgccacctgg cgcaagacct gcgcacagct cgctgcctgc 120 aaggatgagc ttcaggcttt tatcgatcag gtcgtcaagc aggatgattt cgacatcgtc 180 ctcaccggtg ccggcaccag cgagttcgtc ggcaactccc tgttccaggc cctgaacccc 240 aagtacgatt tcaaggtcaa gtcctacgct tctaccgacc tcgtgccttc tcccgagaac 300 ttcctctccc gcaccaagcc caccctgctg gtgaactttg gccgttcggg caactccccc 360 gagtctctgg gcaatgtgga ggccgctgag gtcgtctgcc agaacctgta tcatctgttt 420 gtgacctgca accacgaggg caccctgtcc aagctggcaa acacccgtca caactgcttc 480 gccatcaacc tgacccccga gacccacgac cagtccttcg ccatgacttc cagctacagc 540 aatatgtatc tggctaccta tctggccttc aacctcgaca agctggacga gatcaccgct 600 gaggtggaga agctggccgt cgccggtcag cacttcctcg atgaccagtt cggtctggca 660 cagaagatcg tggacgagtt cgattacaac cgcatcgtct atctgggcaa catcggcctg 720 aagggcgtcg ctcaggagtc cgcactgaag accctcgagc tgactgccgg caaggtggcc 780 actatgtacg actctgagct gggcttccgc cacggcccca agtccatcat cgacgacaac 840 accctgaccg tcgcttacct gagcgatgac gagtaccgcc gccgctacga gctggatctg 900 gtcaaggaga tggcacacca gcgcaagggc aacaagatcg ccgtcgtcta caaccacgac 960 tgcgagggca ttgaggagct ggccgactat cccgtccaga tcaaggttgg tgccgacatg 1020 gagaacgtcc tgctgggtct ggacttcatc ctgttcgcac agaccatcgc tctgatgaag 1080 tccctgtctc tgggcatcac cccggataac ccctgcccca ccggcgaggt gaaccgcgtg 1140 gtcaagggcg tcaccctgta cccctacacg ctgaaataa 1179 <210> 230 <211> 132 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(132) <223> BLCPAMOF_01426 <400> 230 atgagcaaca aggaaaaact gaccgagcgc tggacgcagg gccgtatctc tgaggcgatg 60 ctgcgggtgt atgtccgcaa gggcattatc tcgaaggcgg atttcgagga gatctgcggg 120 aagaagtatt aa 132 <210> 231 <211> 321 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(321) <223> BLCPAMOF_01427 <400> 231 gtgggcgaga agcttaccgc tgagcagtgg ctggaccgtt accagtgggg ccgctacacc 60 aagatgatcg tgggcggcgg catcatcaac ggcagcgtcg cactggtctt cgacgatgag 120 gtggagcgtt accgcaaggc gggctgcgat ttcagcagct gcaccactga cgaggactat 180 ctggccgcca tcgaggcgtt ccaggataac cctcccatgg cagacgccgg agtctccgac 240 cagacccgca ttgcggacgc tctggaagac atggtggcgc tgagcctgcc ggatgatacc 300 accaacacca ccgaagaata a 321 <210> 232 <211> 624 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(624) <223> BLCPAMOF_01869 <400> 232 atgataccaa tttctgatat tctcatccgc tcaattagtg ggtatgtgtt tatggttcca 60 gtcttcgtac tgtatttctt gtggctcaaa aaattgggga gaacacaaag ttttctccat 120 accgctgcag tgtttgtttt tggttattat ttattcggac ttttgaccgt cacaggcatc 180 ggctttacaa gcacaatgac ctttcgcccg aacatttctt ggactccatt tatcggtatg 240 ataactgggc caattgatac cattctgaat attattctgt ttgtcccgtt gggatttttc 300 ctgccgctgc tgtacaagaa atatcatcac atgaagacgg ttgcattgac tggctttctg 360 ttttctttgg ctgttgaaat tgtccagatg tttggctggg gttcttccga catcaatgac 420 ttgatgacaa ataccgctgg agcctgtatt ggatttttag tttattgtct gctgtcaaga 480 atcttgcctg ccaatctgaa aaagcaactt caatccagcc gtgtcaatgc tgtggctgaa 540 gtacttctct ttgctatttg cacatttgcc attatggtca cggctcagac ttggtttgtc 600 catgatgtgc tgaatgttcc ataa 624 <210> 233 <211> 810 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(810) <223> BLCPAMOF_02450 <400> 233 atgaatacat tgagtttgta tgttcaaaga aatgaagaag taatatcagc tgacagccgt 60 tctcttattt caaaaagata ttgcactgta acatcagcaa tgaaccgtga gttttggaat 120 ataacaagcg atagacaaaa tagtatatat gttggctcct atggaagggg aactgcgata 180 gatacaagtg atattgatat tttgatgtcc ttgccggaat catattacaa ccagttcaac 240 tctgtttatg ggaatggtca atctcgtctt ctgcaagtag ttagacaggc tattcttgtt 300 cggtatccaa gaagtgaagt aagagcagat ggacaggttg tgaagatcaa tttttcagat 360 ggaatgttct ttgaaattct gccggcattc aaaaattggg atggctcata cagatatcca 420 gatacaaata tgggtgggaa ttggcgttca actaatccaa aagcagaaca ggatgccatg 480 aaaaacaaaa atataagcag taatggactg ctttttgaca cttgcaagca tctacgatat 540 gtgcgagata actattttag aagctaccat ttgtcaggaa tagttattga cagcttcgtt 600 tatcaagcaa taggaaattg gagatggctt tcctctggag aaagttcaac ttcagcagca 660 ggtacatacg agaagattct tttagattat tataatcagc attttatgtg gggagcgatg 720 cctcttagtg caccaggaag caatcaacag gtgtctacgg ataacagcag agattgcctg 780 ggtaaagttc ttagatatat tgctggttaa 810 <210> 234 <211> 561 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(561) <223> BLCPAMOF_02451 <400> 234 atggagaaaa gttcgctgga ttaccgtgaa aaattatatt ctcaaataca agaagaatat 60 ggaaaacttg tatataccta tacatgtcat tttaagatgg ctgatcggtt gagtaagcgt 120 aatttttgga taaaatgggg acagattggg ttatcagcaa tatcaacagg cggctttttg 180 ggagtgctca tttcaaatga acagatactg ttatgggctg gtggactatg ttcaacagca 240 cttcttgcac taacaagcta tctgaaggat aaggacattt ccactgaaaa aaccgatcat 300 attaagactg caaataagct gtggaaggta agagaaaaat atctgtcact tttgacagac 360 tttgacgaaa ttagtattga agaaatagtg cgcaaaagag atgaactgtt ggatgaaagt 420 tcggaaattt actgtgctgc acctttaact gatgggaaaa gttatgctgc cgcccaagct 480 gcgcttaaaa caaatgaaga gcaattcttt acgcaggagg aattaaacaa gatgcttccg 540 gcgcatttga gaaaaaaatg a 561 <210> 235 <211> 201 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(201) <223> BLCPAMOF_01428 <400> 235 atgatcacgg ataatgcact ggacgccctg acggcgcgga tgctggaagc cgtaaagaac 60 acccgcgaaa gcgcggactc tgctgcagcc agcgcccaga aggcgcagaa gatggcggag 120 ggagagatgc agggaacgtc gctgactggc gcagagaaaa agctgctggt gcagatacaa 180 aatttacgac aacaaatctg a 201 <210> 236 <211> 303 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(303) <223> BLCPAMOF_00835 <400> 236 atgggtacag atatagaaaa actggttgat ttgatgattc aggagcggat gcagagccag 60 ttcgctaaat ggcgggaggc agaaaccggc aaggagaaaa aagcggacta ccttcgcttg 120 gaaaccgagt atgagaaagc gatcagcgca ttgtctgagg aacagaagga cgctgtaagg 180 cactactgcg attctatctt tgattccggc gcagaaagcg agtgcttctt ttaccggctg 240 ggcctcaaag atggcatccg tctctggaag tttatgaaaa agctgatgaa aacggtcagc 300 taa 303 <210> 237 <211> 183 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(183) <223> BLCPAMOF_00836 <400> 237 atgagatacc gtatcgaata cgccgatggg cgctactgta actttgccaa cggcagggct 60 gaactgctga aatggttgaa actgctgaag caagaggaaa cctccgacat ccgcaaagtg 120 tataaaagcg gtgtgtcgga ttccgtcctg gaaacatacc ggaattatat ccgtccagca 180 taa 183 <210> 238 <211> 1290 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1290) <223> BLCPAMOF_00716 <400> 238 atgaaacacc cgcttcagga aatgatggac aagcgccgcc agggtatccg ctgcggcatc 60 ccctcttatt gcagcgccaa cgagctggtc attgagatcg cgctgcgccg cgccaaggag 120 cgcaacatcc ccgtcctgat cgaagccacc gctaaccagg tcaaccagtt tggcggctac 180 accggcatga agcccgccga cttctaccag atggtcctga aaatggccaa ggacatcgac 240 ctgcccgaga acatgatgat cctggcaggc gaccacctcg gtcccctgac ctggcagaag 300 ctgcccgagg ccgaggctat gaagaactcg gtcgagctgg tctaccagta tgcccgcgca 360 ggctttacca agatccacct cgacaccagc atgaaggtgg ctgacgacgc tcccggcctg 420 ctcaagaccg aggtcatcgc acgccgcggc gcgcagctgt acaaggcagc tatgaagggc 480 tacgaagagc tgaaggccga gaagcccgat gcaatgcgtc ccgtcttcgt catcggcagc 540 gaagtgccca tccccggcgg tgctaccgag gctgaggaca cgctggctgt caccagcccc 600 gatgctttcc gcgacaccgt ctctacttac cagcgcgtct ggaccgaaga gggcgtgggc 660 gacggcatga aggacgtcat cgctgtggtc gtccagcccg gcgttgagtt cggcgacgag 720 caggtgttcg actatgaccc tgccgccgct gtggacctct gcgcagccct gaaggagttc 780 ccggacatct gcttcgaggg ccactccacc gactaccaga ccgccaccga cctgtacaac 840 atggtcaccg acggcatcgc catcctcaag gtcggcccgg ccctgaccta cggcctgcgt 900 gaggccctgt tctccctgag catgatggag aaggagcttg tccccgagga aaagcgcgcc 960 aacttcatcg agactctgga ctccgtcatg ctggcctccc ctgcaaactg ggagaagcac 1020 tatcacggcg atgagaagca tctggcacag tgccgcaagt acagctactc cgaccgcgcc 1080 cgctactaca tcggccagcc cgaggtggtg gccgccatga acaagctgtt cgacaatctc 1140 cgcgagtacc ccatcccgat gaatatgctc caccagtata tgcccatcag ctacgcaaag 1200 atccgcgagg gcaagctgaa gctcgacccg cgcgagctgg ccatggacgg catcgtgcag 1260 ttcatgctgg actacgagag cgctgtctga 1290 <210> 239 <211> 1383 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1383) <223> BLCPAMOF_02061 <400> 239 atgagtttgc caaagcgtga tggcgtacat gaccgctact atctgatcca caagccggac 60 acttccctgg aggtgctggc ggaggcggat ctctgcattc aggatgtgct gaacggaacc 120 gctcgtgaaa atcactccgc ctacccgact gtggtgcgaa atcataacgg aacacccttt 180 ctcccggatc agctgctgga gcggtatctg accgggctgc cgctgaaagg atttccctgt 240 gaggatgctg cctctctctg cgacgccatg cggcggctgg tgggctggca ggagatccgc 300 tatacattgg agaaatacat agaaaagcag gtgcaggaaa ggtattttga ggctggagaa 360 aaagaggatg attttacgcc ttacccgcct tgtactgtgt ggccggagct gcggccggag 420 gatgtggatg aaggcctgct gcgctttgcc tgctatgtgg cggtctgcca tacggtgtac 480 gggcagagtt ttgaatccct caccaccgag cacatcctcg gcctggtctc ccagcttcgc 540 ccagatatgg tgaagcagct gaaaacagcc ggcagcggca aattaccaaa ggacatccag 600 cagcgtaaga cggagcattt caacgcatcg gccaatgatg cgtttgccac tatccgcatc 660 accgccaggg actccacgga ggagtgctat gctgaaatcc tggactacct gtgtgcggtg 720 ctggagcagg aagaatttcc ccgcagttac tcggtggagt tccgtgggaa ggaaaaactc 780 tatctgccca ttcccggctt gccccaaaag ggcgtcaatc agctctttgc ctgtgctgtg 840 cagcaccctg atcttcatcc ggctatggag cgatacgctc gtttggctat gcgggagttt 900 gagtggtatc aaaaccttgc ggatgaagcc tgcgccatgc ctggcacctt tgccgtgttc 960 gccctgggac tggaagggcc gaagtggtgg cggctggtgt gcgattacct ggatcgatgt 1020 gatgacgagc actcctcttt gcaggagaag ttcctgcata ttctgttcaa gcagtacggg 1080 ttcactgccc agtccctgcc ggtgctggtc cacggagtac agtccatgca gaatctgaag 1140 cccgcaaagg agttccgcgc cctgatcgcc aatgaggaga gcctggatgc tctgctggag 1200 atcaaagggc atctggaata ttacctgccg gaagaatccg gcaatgacaa aagggcgctg 1260 gcctacctgt ggcgtgatgt gctctgggcc atctggggca cagcctctga aaacggcggc 1320 agcaaggtta tcaagacagc gcccaaggaa ctgaaagaga aataccagca agtatttgcg 1380 taa 1383 <210> 240 <211> 630 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(630) <223> BLCPAMOF_01141 <400> 240 gtgccggaca tctcgctgtt ggtgccgctg gccgagcagc tgaacgtgac ggtggccgag 60 cttctgcagg gacgccgggt agaggaggaa cagcgcttca cccgcgagga gaccgaagat 120 ctcatccgca aggcgctgac cttttcggca gagccgccgg agcgccgtca ggcgcggacg 180 aagaagtatc tgccggtgta tgtcatctgc tgcgtgctgg gcgtcgcaga agcgctggcc 240 gtctgggcgg cgggactggc cgacatcgag ggagcgctgg ctctgctcat cgtcgatgtg 300 gttttcggcg tcgtctacgg ggcctatgcc atgttctgga tgaccgagac cctgccccgc 360 tactacgacg agaaccgcat ctgcaacttt gcacagggtg cgttccacat ccacatcccg 420 ggcatctatt acaacaaccg caactggaag cacatcctgc gggcgttccg ggtctggtcg 480 atggcgtcgc tggtgctggt gccgccctgc acggcggggg ctgtcctgct tgaacgcgcc 540 accggctggc aggtgtgggg cgtggtgctg gtggtgtata tcgcctcgct gttcggggcg 600 atcgtgatac cggcgaagag gtttgagtga 630 <210> 241 <211> 156 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(156) <223> BLCPAMOF_01970 <400> 241 ttgaaagtga gaggtagaaa gctgacccgc cgccagaaag aagccctctc tgctgccggt 60 tgggactgca ccgcatatct ctgggttcgg gatatcccga acggtatggt gctcctgaat 120 aaggacaccg ggaaaaccat catttttgga aagtaa 156 <210> 242 <211> 2493 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2493) <223> BLCPAMOF_01225 <400> 242 gtgcctgtag agaaacgcaa tattttcctt catgaaacgc agcatgcctt accgtatgtt 60 tcaaaacgaa aaagatcgga tgcatcgttt ccttgccgcg aaaatccaaa ggcgcacgcc 120 gcttttattc ttcaaaaact tgaggcctgc agacagcaag attatgatca gaaacaagta 180 gcggctatta ggcataaaga aggaatctat cttgaatttt caggtgcagc aggatacgat 240 ttgcttacaa aatcctttga caattattct tcaggtatac gtctgcttaa tgtacgcgaa 300 gatgggcaag acgatgaaaa aattgttagg gccactgttt atgttcctgc agaaaaaaca 360 acatatttcc ttgataaaat ccaatcgtat tcagagtcgc tagacacgct agaagccgga 420 caaaatccca aaaacgacag tttagttcgg agtattgaag atgtaaaact tgctttgctc 480 gaggcgtttt gggtaggaaa agtagaggat ataccttctg atgttccagc gtggtgtgaa 540 atatggctcc gatatgaaaa atccgatcat gcagcagcgg agcaagatct ttctacatgc 600 tgtgaagaat tcggaataga actcaattca aagtgtattg tttttccaga acgagtagtt 660 cgactcgtcc gaggtacgcg tacacaatta tcgatgctgc ttgaggggtg caattattta 720 gctgaaattc gtagagcaca agaaccaaca agtttttttg atgagttaac tggttctgaa 780 caaaaagaat gggtaaacga tttgttatca agaacagaat ttcatccttc aagtgcttcg 840 gtatgcattc ttgatacagg tataatgtat tcacatccac ttcttcaacc agcgattgat 900 gagaacaacg tacaagcggt taacgaccaa tggggaaaaa atgaccataa cggacatgga 960 accgaaatgg ctggcgttgc attgtactat gatctcaagg acaaattaag tacttctgac 1020 acagttgatg tgtatcacca tctggaatct gtaaaaattt tgcctcctca cggagagaat 1080 gatccagact tgtatggtgc ggtgaccggg caagctgtat ctttggcaga aatttccaat 1140 ccgaatgcaa atcgtagcat ttgtatggca gtaacatcat cacaatataa tactaacgat 1200 ggaagtccaa catcgtggtc tgctgctgta gacaacattt catccggtgt gggtgaagaa 1260 gatgcaaagc ggttattttt cattagtgct ggaaatgttg atccttctga aatgcacgat 1320 tcaggttacc ccaatgccaa tgaagtacat gtcgttgaga gtcccggcca agcatggaat 1380 gctttaactg ttggagcata cacgaaagat gtctgtgttg atgatgagaa ctacagaggt 1440 tttactcctg ttgcagataa tggacagctt tcgccgtata gtgctacttc tttgatgttc 1500 tctaaaaaat ggccaattaa gccagagata cttctcaatg gcggcaatat ggtgacaaac 1560 ggtaccgatt atgattcgtg tgcagattta tcattgctga ctacaggaaa aaatcatttg 1620 gtaaggccct tttcaacaat ttgggctact agtgctgcta ctgctcaggc ggcatatatg 1680 gctgctcaga tatttgctga atatcccgat gcttggccgg aaacggtacg cgcactatta 1740 gtgcattcag ctcgctggac accgcaaatg gagcagcaat tttgtacaga cacaaggaaa 1800 tccagtggtc gaagacacct gcttcgcaca tgtggatatg gggttcctga tcttgaacga 1860 gcaattcaat gtgtagacaa ttctgtgaat ttaattattc aagaagaaat gcagccatat 1920 gaaaaagcga atggagtatc tcaaatgaaa gagatgcatt tgcatcaaat tccatggcct 1980 tcagaggtac ttcaatcact tggaacagtt gaagttgaga tgcgcgttac tctgtcgtac 2040 tttgttgaac ccggccccgg agaaaaaggc tggaaagatc gttaccgtta tccttcttgt 2100 ggacttcgtt ttgatgtcat caatagcaat gagacaatag aagatttcaa gaaaagagtt 2160 aacgtaaaga tgcgtggaga tgataaggct gacagcggtg acggtagtag cggtagtgag 2220 cgttggtttc ttggttcgga caatcgagat gtcggctcca ttcattcaga ctttattaaa 2280 gcaactgcag cagaactaag ccaagcaaag tatttggccg tctaccctgt agttggatgg 2340 tggagagaac gaagctactt aggaaaagtt gaaagtaaaa tcagatattc cttaatcgta 2400 tctatttcta ctccggatgt atctgtggat ctgtacaccc caattgttgc acagattaat 2460 aatccaatcg aagtggaaat cccaacagaa taa 2493 <210> 243 <211> 714 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(714) <223> BLCPAMOF_02581 <400> 243 ttgttttttg cagattgtag aagaaagatt atggaaaata aaggaaagaa aaaaagcagt 60 tcaaggaacg atatatcact tgaccaagca atattacagt ggattgtgga tgattatgat 120 atttctgatg aaaaatccag aaaaatagta ggtaaaagtg aagaaaaaag taaattaata 180 acatgcgaaa tggtaatgaa ttatctagac aatcgaggtg tattagaaga aacagatgaa 240 acggaattta tgagatcgct tcgaaagcgt ctttattatg caattgacac agtcgttgga 300 ccaattccaa tgaaatcgaa aagtatcaat gcacatgagc tgctcagaca aaaaagtcaa 360 tcaaaaggac gattttatgt gacttcagca aatgcggaat tttttatgta tttgctttgg 420 tgcaatgaag atagagccga caatgacgat attttgtggt taataaagaa cgaaaggaat 480 tatgaagcaa gtgaatggct gaaaaatttg attagagacg gctttgattc attgattgag 540 aaccctgcaa taggaataaa acaaaaaact gttgaaaggc gatggaagga attatttgaa 600 ggagaattag ccaaaaccaa agatgcatta gaatcattaa atctgacgtg ggcatatata 660 gaagatcgga agaaaatggc aggggatgaa tttgatgaag agtggttgac ttaa 714 <210> 244 <211> 687 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(687) <223> BLCPAMOF_00310 <400> 244 atgaagccct gtccgcattt tctgaaaaga ttcgcagttc tggcagctgc ctcactgatt 60 ctgagcgcgg tcactttaag tgccagtgcc gcagcagctc ccgtaaagta tgaagaaaag 120 cgttccactg ttaccactgt cgatggcgca cagaaaaagg aagatctggc tgtgaccgtc 180 gaatatcagg tcggctccac ctctatccgg gcttatactg tagaaaagga tgaggtcatc 240 ggtgtatcaa aggatatgtg gtctctttat ggtgccttta cttctgattg gatcaccgat 300 ggcacctata ccctctctca gccgctgaac agtgtggaac agatcactgt aagcgttcct 360 tacggcgaca cagcccgcac gaacgagagt tattttgtat tccatgttcc cgaaggcacc 420 gtcgtcacta ctccttcctg gagttatgac atggaccttt ataagggcaa gaccattgca 480 gatgtaaaag ccgtagtgga agccggtcag gaccccaata ccctcattga cattgaggac 540 gattacgacc ccttcgggcc cgatcttgaa tataccgaca cttctgcgat ctatcacctc 600 cgtaaaggtt acctctaccg cgtaagcgtc agctccgccg aagagtcttt ccctgttccg 660 gagaatttct atttctgtgt agattaa 687 <210> 245 <211> 714 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(714) <223> BLCPAMOF_00090 <400> 245 atgatataca ttgtgaaaaa acacgagcca agggaattaa cggaataccg tgaaagcgaa 60 tcaagcactg gtgtacgacc gacttatgat tccatgagta gcgacctgca tgagtatgtt 120 ttgtcaaagt tggtggaaga acagggagga ctgtgcgcat actgtatgtg cagaattccc 180 gaaaccgaca aaaaaacagg aagtacattg aagtgtacga ttgagcatat tgaacctcag 240 agcctgacga ggggcactga aaacttgaag aaggaattgg agtacagtaa cttccttgca 300 gtatgctcag gaaatgaaaa ccgaggggct ttatgctgcg ataaatcaag aggaaacaaa 360 aaactttttt tgacaccatt aaatcctgag tgcaatcatt tgatacaata ctctctcagc 420 ggtaagatac aggctgccga aacgatacct gataaggagg acagaaaaga actcgattat 480 gaactaaatg atattctgaa cctaaacgat ggtaaggatt tgaaagccaa gagaaaaagt 540 gctcttgatg gtatgctgtc agtattgcaa aagcagcata aagatcaaga tgttgaagaa 600 tgcagaagaa agttaagaga gctggaaaca cctagaggtc aaaaagttga atacgtcggg 660 attttaatat tttggctaaa gaagcatatt caacatcttg aaagcagagg ataa 714 <210> 246 <211> 162 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(162) <223> BLCPAMOF_02268 <400> 246 atgctgagcc gcgccgccag tgtattgcgc ggcaagacgc tcatcgtcaa cctgccgggc 60 agcccgaaag ccgtgaagga gaacctcgag tacatcctgc ccagcctcgg gcacggcgtc 120 cgcatcgccg ccggtctgga cggcgagtgc gcccgcaagt aa 162 <210> 247 <211> 1044 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1044) <223> BLCPAMOF_01947 <400> 247 atgagcgaat ataccatttc gcaggtctat ccgaccgata aaaccgttct ggcccaaatc 60 gacacactgc tgggtcagga gggcatccgc cgcgacggca atctggacta catctgcgcc 120 atgttcgacg aggaatacaa cgtcatcggc accggcagct gcttcggcaa caccctgcgg 180 tgcttcgccg tcagcagcgc ccatcagggc gagggtctgc tgaaccagat catcacccat 240 ctcatcgagg tgcagtgcgc gcgggggaat atgcacctgt ttctctacac caaggtaaaa 300 agctccaagt ttttcggcgc cctcggcttc tacgagatcg cccgggtgga ggataccctt 360 gtcttcatgg agaaccgccg caacggcttc ggggcttatc tgcgcgatct ggaaaagact 420 aggaccgagg gcaaaagtgc ggccctcgtc atgaacgcga acccatttac cctcggtcat 480 cagtatcttg tggaaaaagc cgctgccgcc tgcgacacgc tccacctgtt cgtggtcagt 540 gaggacgcca gcctcgtgcc ttttgccgtg cgcaggaagc tggtggaggc gggcgtggcc 600 catctgccga atgtggtgct ccacgacagc ggcccctaca tcatctcgaa tgccaccttc 660 cccagttact tcctgaagga tgaggcagct gtcatcgacg gccacgcccg gctggacctc 720 gccgtcttta cgaaaatcgc ggcggcgctg aacatcactg cccgctatgt gggcgaggag 780 cctaccagtc aggtgacggg gctttacaac cagatcatgt gcgagcagct gcccaaagcg 840 ggtatcgagt gtgtcgttgt accccgcaaa gaagcaaacg gcaaggccat cagtgcttcc 900 accgtccgcc agtgcctgca gagcggcgac tgggataccc tcgagacgct gctgcccaag 960 accagcctcg actatttccg cagcccggag gcagagccgg tgctggcacg catccgcaat 1020 gcgggcaatg tcgtgcatta ctga 1044 <210> 248 <211> 777 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(777) <223> BLCPAMOF_00882 <400> 248 atgacagtag gtatggtacc cggggcaagc atcgcaggca tggtgttttc ccttgtcgtc 60 tccttcgcac ttcccatagg cctctttgtt tacgcaaaga agaagctggg tgcgaaggct 120 gcaccgttct ttatcgggtg cggcgttttc tttgtgatgg tgctgatgct ggaagctgcc 180 atccatcgca tcgtgttcca gctggccgga gaagcgctga ccggaagcgt gatcctatac 240 gcagtctatg gcggcctgat ggcagctctt tttgaagaga ccggtcgtta catcgccatg 300 aggtttctgg tgaagccgat ggactttccg aatgccttta tgtatggtgc cggacacggc 360 ggcgtggagg caatgcttct gtgcggcgtg gcatctatca gcaacatcgc aagtgccgtg 420 atgataaact ccggcaccat gtctgcacag ctggcgtctc ttgacgcaaa gaaggcggca 480 gacacggcag cggctctttc ggcgctgtgg acgaccccca gcctgacctt ctttgccggg 540 ggcgtggagc ggatcattgc ggtggtgctc catctgagcc tttcgattct ggtgttccag 600 tccatccgca aaaagtccca gaaagacctg ctcaatgcgt atctgttcca ctttgtcatc 660 gactcgctgt ccgttctgct cagtgcagtg gcatctgtct gggtggtgga gcttgtcgtt 720 gcactcgtga ccggcggggc tgtcctaatg gcaaagtatg cctgtatgga agagtga 777 <210> 249 <211> 1401 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1401) <223> BLCPAMOF_01948 <400> 249 atggaaacga ctgtttcgct ggtccagatg ctggatgcac gggagcgccg ggtgcagtat 60 cagcaggagc tgctggctca gtaccacaag ccgctcatct gctttaccat gaatatctgc 120 ggcccggtaa aggattcgcc cctcatccag cggggctttg cgcgggggcg tcagctgctg 180 cgccagcagt ttttgcgggc aaagctggcg ccgctgtatc aggacaccgt ccgggaagtg 240 accggctgcg aggcgttcta tgtgctggac gccgacccgc tgaccatcaa gaaattcacc 300 accgacatcg aggacgctac cccgctgggg cggctgttcg acatggacgt catccgcccg 360 gacggcctca aagtggacag agaagagcta aacctcgaag gccgccgctg tcttatctgc 420 ggcgggcctg ctaaggtgtg cagcagccgc cgtatccata ccgtggccga actgcaggaa 480 aagacgacgg agatcctgac cgaggcccgg gacgcgcagg acatcgccga cgcggcccgt 540 ctggccgtcc gcgccctgct ctacgaagtg accaccaccc caaagcccgg ccttgtggat 600 cggcgcaaca gcggaagcca cagggacatg gatgtgttca ctttcatgga cagcgccgcg 660 gcgctctacc cctattttga agcctgcgcc cggacgggcc gcgagacggc ggaacagtcc 720 gcgcccgaga ccttcgcggc cctgcggccc ctgggttgtg aggccgaggg cgagatgctg 780 gacgccaccg gcggcgtcaa cacccacaag ggagcggtct tttcggtggg catcgtctgc 840 gcggcgctgg gacgcctcga ccgctccctt tgggtggatg cagcccgcgt tctgtcagaa 900 gtatccgcaa tgacggcggg cctgaccgag aaggattttg caggcgtcac tgccgagaac 960 gccgccaccg tgggccagaa gctttatatc cggtacggca tcaccggtgt gcgcgggcag 1020 gtggaagctg gacttcccgc agtgctgaat gtcggcctgc cggtgctgga agagggcctt 1080 gccaagggtt acgacttcga ccgcgccagc ggcggcgcac tgctggccat cctggccaac 1140 agcactgata ccaacatcat tgcccgctcg agccgggagc gtcagctggc cctcaccgaa 1200 gagctgaaag cccttctcgc ccagacacct tacccggata aagatgcgct cgcggcgctg 1260 gatgaccggt tcattgcgga aaatctctcg cccggcggca gtgccgacct gctggcgctg 1320 acctggctgc tccattttgt tactactgag gggaatatca atgagcgaat ataccatttc 1380 gcaggtctat ccgaccgata a 1401 <210> 250 <211> 576 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(576) <223> BLCPAMOF_01667 <400> 250 atgcagacct caaagaatca ttttgaagcc aaagtggtct ttaacgatga gaccatccgc 60 cggatgttcc gcacggagtt ctacacctac gagggaatgc ggcacctgct gtggctcgca 120 gcagcttttg tgctggtgat ggcggcgctg ttcaccgcca tccctaccgt tgtcaaggtg 180 ctctgcctgc tggtgggctg cgccatgttc gccatgccgg actttttgag ccgggtggcg 240 gcagaggggg tcatcatgca gcggggcggc gcggaaacca ccgtgagctg ccgggtcaac 300 gatggcggcg tagacgtgga aaacggtgct cacattccct ttgcaaagat cgaccggctg 360 gtggaggatg accagtattt ctacatcttc cagagccgcc agatggcagt catgatcccc 420 aagggcagcc tgctgccgtc aaacccggag cggttcgcaa aggtgcttgc caaggagacc 480 ggcaaggact ggcagcgctc caagagcctg tgggggctca acctgaaaga cctgatccag 540 atgggaaaag accgctttca gcgcagcgcg tcctga 576 <210> 251 <211> 117 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(117) <223> BLCPAMOF_01433 <400> 251 atgttttcgc cctatgacaa cgcaaatgcc cgcgaagagt ccgatgctat gcaaaagcta 60 tcccccgaag ataaatccgc ccgatgtcaa gtcttggaca acttttttca caaataa 117 <210> 252 <211> 282 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(282) <223> BLCPAMOF_01924 <400> 252 atgaaaaaaa ttgaaaatac cgctttgcag atgattgccg aggcttcccg gtgtccagac 60 tacggccccg atatggttaa atcgctgatg aaaaagctgg acatgaacga aaagggcttt 120 gcgcttttga tgaatgttgc cccatccaca gtgcgtcttt ggaccagcgg agctgcacag 180 ccctgcggca cagcaaaacg cctcatgcag atttatgaaa ccggtccgga gattgttggc 240 aagattgcca gagggcagct accggcagat gggagggatt ga 282 <210> 253 <211> 288 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(288) <223> BLCPAMOF_00720 <400> 253 atgacgatca actgggaagt tatcatctgg acctgcatca cgctggccgt gctcatgagc 60 atcatcggcc tcatcctcta cgctatctcg gccaagaacg tgcgcagcaa gcgcaaggag 120 ctgggtgagg tacacacgga gctgaaagta ggctcccgca tcatgttcgc gggcggcgtc 180 tacggcaaag tggtcggcat cgacgacgag gacactctcc gcgtggaggt ggcccccaag 240 gtcgtcatta ccatctcccg ctacgcagtc cagagcctgc tgaaataa 288 <210> 254 <211> 831 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(831) <223> BLCPAMOF_01920 <400> 254 ttggaagaaa ataaagatta tcatgcctac cggtatggcg accacttgac gccgggattg 60 gagcttaaaa ttgagcacag cgtagtttgt gaaaatgtgg atatttctac actgatcaca 120 atgggaacag atagcctgga agccatgcgc cagggaagta tcgacgggga gcagaaagcc 180 tatgaaatcg tggtggctgc cgcaaaacag tgggaacagc aggcagcggc aacacagacg 240 atcaaccggg ctttggaata tcttcgtaca cctgagattg aacataccgg caatcagtgg 300 aaagacaccg ataactggag ggcggatcag aaaatcagca accgggtcta tcagatgacc 360 tgcagtattt gggaagatac gaaatatgac agggaaacaa aacagagtat tccggttgcc 420 tggtatgtga catgggaagt ccgtattcat tccccgaagc agggatatgg agaaaagatt 480 gccggacaaa accagaaacg atatacagat aagaatgcag ccataaaata cctggacggg 540 cggaagaaag cctattccca tttattcacg gaaatttccc cgccaattcc gaaagaatat 600 gagcgtcatt ttatggttca tggcactctc ttacctggtt atacggttga aggactggaa 660 cagaccaaaa cggaacatgc cgccgccgag gtttcggagg gcggtatttt tacgccccaa 720 aaccaggaga agccttccgt cctggggaag ctctctgtgg caaaaaccca ggaaaaaacg 780 ccagccgctc ccggtatggc aatgaaaaag aaggaggata tacagttatg a 831 <210> 255 <211> 771 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(771) <223> BLCPAMOF_01923 <400> 255 atgacggaga cagatagcca gccgattgcg gaaaatgagc aggtcaaaga gctgcttgct 60 ctcctaaaag acaacaatac accgggatat gaagaatttg ccaagctaat cgagcatgtg 120 accgggatgg agcagcgtct tttggaggca accgaggaac taaaggcagt gcgtcaggaa 180 atgcagggat tacagaacca ttccctgaaa gatactctcc aaaagagctg taaagctatg 240 gagatgaata tttccgttat gcgtcaccgt ctttccgaac tcaaaggcca gatcataaac 300 gggtgcagga atatccttgc cgatttcagg gaacgaggta ctgttgcttt gaatgggatc 360 acacagtttt tacatgtcag accggtgttg gagtccattc aaagtgcagc agaaaaaagt 420 atgcaggcca acaacagggc tgttgccaga attgacgctt tcagtacgga atatcacgaa 480 atggagcggc atctcaaaaa tatgggccgt gctattcaag gaaaacctgc ggagacagac 540 gcaaaagaaa atggaaagat tgccagggtg ttcaaaggtg ctttcaaagt ggagggcgct 600 cttatatcct ccattaaccg taatgcggag tgggcactta atacccttgc ccggttggaa 660 cagactgcgg aaaggcgccc ttctgttttg gaagcaatgc gggaacaggc agcaaaaacg 720 gaaccggcaa aaaagcagcc ggcatcttcc catgataagg aaagccggta a 771 <210> 256 <211> 951 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(951) <223> BLCPAMOF_01434 <400> 256 atgaataaca gtcaggaaat tattttggct caaataagcg caatatatga taaaccacca 60 tttgtgaaag tgaaaacggg tcaaatggaa atgattttga agtgtgttgg attaggaaaa 120 tactatgatg agtatgcaaa atatcttgaa ccatactggt ataatcgggg atttcaaaat 180 gatattgagt catatagaat ttttgttggt ttgaattcga tatttgagga tttgttaaat 240 gcgcataaag gtgaagaaat tatttcgttg ctaacggagt tgggtaatca cattcaagga 300 aatattttgt gtgatggtgg agattttgtc aatgatttta acaggctgtg ccagttatat 360 aatttgatgg gcttgcagat agtttcgaca gaaattgatg aatattcttc taagtttgag 420 gttaagccat atttgaacga aggaaatcat attattcaat cttttggaat ggagcagtgg 480 ttaaaaaaca aatatcagga tgtatatgct tcctatgaga gtgcattaaa ttcatttgaa 540 cgtggtgaca tgggagctgc aattgaatca tgtagaacag cattgacagg gatattttct 600 aaatataaag gagtgccttt tcaaaatgca agatggatgc ttggaatggc aacaataact 660 ggggatttta caggaacaca gcctgcagat gcttccgaga tgactccaat aaaaaatgcg 720 attgaggcaa tgggaaaaag agacatagca gatttttttg atgaaaattt agaggggtct 780 tataaaaaaa caaaggctat ctacagtata tattctatgt tgtcagatta cggaacacat 840 cgattagagg gaacggtaga agtggccaga aacgaagacg cactaatgat gattagaatg 900 accacagaca ttcttgtttg gatttaccaa aagcatggca tgaatgaata a 951 <210> 257 <211> 393 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(393) <223> BLCPAMOF_01438 <400> 257 gtgaaattag ttgcgattca tcatgtggca atcatcgttt ccgactatga aaaagcaaga 60 gatttctatg tgaacaaact gggctttgca gttgtgagag aaaacttccg caaagagcgg 120 aacgactgga aactggattt gcgtgtcggt gacggagcca atgcgattga attggagatt 180 tttgcagagc cgaacccacc caaacgtgta agcaggccgg aagcctgtgg tctgcggcat 240 ctggcgttcc gggtggatga tgtggaagct accgtggaag aacttgcaca gatgggaatt 300 gaatgtgaac cgattcggtt agatagctac accaaaaaga aaatgacatt tttctttgac 360 ccggatggcc tgcccttgga actgcatgaa taa 393 <210> 258 <211> 552 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(552) <223> BLCPAMOF_00642 <400> 258 atgccagagt tcccgcgcaa agatttccgg ctccatgtgg gctggcgcac catcaagacc 60 gccgtcagtg ccatgctggt ggccatcgtg tactgtctca tcggccgcaa cccggctttc 120 gcctgcatcg gcgtcatctt cggcatgggc gtcgatatgc aggattccat caaaaacggc 180 ggcaaccgac tcttcggcac tctcatcggc ggcctgctgt ccatcgtggt gttctggatc 240 tacctgctgt tctacccgca gggcggacac agcgtttttc tggccgtgct gctgggcttt 300 gcaaccgttg tcctcatcct gctgtgccag tatttctggc cgggcggcgt ccagcccggc 360 ggcgtggtgc tctgcatcgt tttgttcagc acccccattg agacctatat gagctacgct 420 ctcaaccgca tcttcgacac cgccattggc gtcatcgcag cgctgctggt caactacttt 480 ctgccccggc cccgggtcgt ttccctctgg gaagggttca aaggctcgtt caagaaggac 540 agtaaagtct ga 552 <210> 259 <211> 123 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(123) <223> BLCPAMOF_02449 <400> 259 atgactgata ctcgaaagaa agcctctatg tcgcaggtgc tggcagatat aaagccttac 60 ataacgaaga agttcatggc ggcaccgtgt ataaataatg ttttgaaatc agggatgagg 120 tag 123 <210> 260 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> BLCPAMOF_02431 <400> 260 atgaacgaga atgttgacgg tatgatgatt cgtctggtcg gccttgcact ggctgtcctg 60 ttgatggctg gcatgaccat ctacacgggc cttttcaaaa agacatccgg catggatgcc 120 cgcgccactg tcatcagtgt gcaagacggc catgtggccg cagaggatgt ccagtggaac 180 gcctga 186 <210> 261 <211> 240 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(240) <223> BLCPAMOF_02194 <400> 261 atgaaagatt cgacgaaaga agcactgttc aagtttggcg agttctgtga ttccggcaag 60 ccgtggtact gcttttttgg tgtctatctg gtgacgctca tcgtcaatat cacccttctg 120 ctcacctcgg agcggaagcc caagtggtgg agcgtggccc tcgacgtgtg cggtctggcg 180 ctggcggcgt cgaatattgc caagaccgag atgatgcaga aaggccggca taacacctga 240 <210> 262 <211> 864 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(864) <223> BLCPAMOF_01037 <400> 262 atgaggataa ggagaaataa agtacataag attgttttaa ttgataacgc aagtacggat 60 ggaaccgtcg atttgtttat aaaaggcgga gagtatgaca aaggcgtaat agattatcgc 120 aaaatggaaa ccaaccttgg cggtgcaggt gggttttacg agggaattaa gatttgcaga 180 gatatggaat gtgattacgt ctggattatg gatgatgata cgattccgta tacagattgc 240 ttagaagagc tgatgtctgc cagatctaaa attgagggta aaataggata tttagcaagc 300 tcgattattg gaccggatgg tgagccaatg aatgtgcctg ccattgatat gcgtcctgca 360 aaaaatggat atccgcactg gtataaatat ctgtcggatg gcatcgttca gatttcaaga 420 gcgacttttg tttccatttt ggtttcctat gatgcaatca agaagtgtgg actcccttgt 480 aaggactact ttatatgggg cgatgattcg gaatacacca tgagaatatc aaagtattat 540 gcgccagcct attttgtagg tgctagcgta gctttgcaca agagattcaa cgcaaagaaa 600 ttggatatta tgatggaaaa cgacacaaaa cgattggaaa tgttccgaaa gtattatcgt 660 aatacaacca tcaatgaggg gctttttgta agtcagaagc aaagaaaaaa attggtcatt 720 cacaatttta aggttgcact tcagaaattg cttaaaggtg actttatcag agctaaagtg 780 attttccttg gaaccttgga ttctattact cagagaaaaa agtttgagga atatattgcg 840 aatgaactgt ctttgcaaaa ataa 864 <210> 263 <211> 141 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(141) <223> BLCPAMOF_02598 <400> 263 atgactacat cggaaattct attgcttttc cagacgatca tcgcactgtt ggcacttctc 60 gtaagtgtcg tacacttgat ggacgaccgg aaaaaggatg attcttatgg cagcaaaagg 120 aaaaagcaca aaaagaaatg a 141 <210> 264 <211> 231 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(231) <223> BLCPAMOF_01035 <400> 264 atgtgctatt tggtagcaaa agatcgtaat gcacatggtt gttttgctct aaaaacgacg 60 catggaaagc atctggtgga attaaaaaga gaattgaaca gagaggttgg atataaggga 120 gtacagcttg taacaatcag caggccaaca gcgtatggtg agtatgcgcc ttaccacttt 180 gtggatacag aacaggaatt tcagactctt gtaaagggtc ttcgtccata a 231 <210> 265 <211> 624 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(624) <223> BLCPAMOF_01034 <400> 265 atgaatgagc aattgctgaa aatgaatggc ttatcggtgg gaattttaga tgcactatca 60 tttgagtcgc atttgggaat tccgttgaag aagaacttgc attattttga taaggatttg 120 ttaattgctg aactgatttc gatgactgag tggttggatg aacaggaaat cctttctaat 180 attgcgctag actacagggt taagagcttg gattctatac ttttgaagta tgatcgttac 240 tatccgaatc atcagacacg aaaagtgttt aatgatattc tgggcttccg ggctttttgt 300 gatagctacg atcaaatatt agaagaagag ttttcaccgt tccggattgc tgatatggca 360 aaaggaaagg cagtggatga tggttacagg ggtgtccatg tgtactatca gaaaagtgga 420 agacattacc ccatagaaat ccaatttaat acgttgtttg ataggcaatt aaataactgg 480 cttcacgatt atctgtacaa aaagaattat cccgtggaaa caggggagat aatgcgtgaa 540 aagtatgaaa atggattgat tcggaatgaa catgaattta aggaggtgct gaataatgtg 600 ctatttggta gcaaaagatc gtaa 624 <210> 266 <211> 222 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(222) <223> BLCPAMOF_02757 <400> 266 atgggaatgt ttcatgtgca tttcggcggc acagaaagcc tttccgaagg agataaagaa 60 tatatcgttc gcattatgga agtaatgccg aaaaaaattg gttgtctgta ctttcctgtt 120 gttgtaatgc cggagcgtaa ggtggtggca tataaggcag tacgcaacaa tgagaaagtc 180 gtgataaaaa gagattgtat caaatgtcaa ggaggaactt aa 222 <210> 267 <211> 201 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(201) <223> BLCPAMOF_02756 <400> 267 atgaagaacg tgaaaaacaa gaaaatgatg gctgttgttc tgccggaggg atgcttctac 60 ggaaattgta gcgactgcgt ctatgctgac cggagtgact ggagagacgg cgaggtatac 120 tgcctttgcg agaaaggctg gacacacggc tataatcgcc cgagtgaccg gaacggttgt 180 gcctactatg aggaacgctg a 201 <210> 268 <211> 255 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(255) <223> BLCPAMOF_02755 <400> 268 atgacggttg cattgtgcat gtttgccctt tgggcatggg gcggatggat ctcgtggaag 60 ggcattgaaa acggaaatgg ctggatcggt gttatccttt ccgagaaaat acgcaaaagt 120 ctgaacaaaa aagaaaactg gtggaaaaag gcgcttcttt cggtggcatt cggctatgtt 180 gcaatgggtg caaaggtgat agagtggatt cttacttttg tcatgcgcat ggtggacggc 240 tcgcttttta gatga 255 <210> 269 <211> 999 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(999) <223> BLCPAMOF_02591 <400> 269 atgtccgaaa atgcaagaca agaagttgtg actcaaaagc cgcgcatggc aatatgctat 60 gacttcgata aaactctttc tcccgatgat atgcagtcgt tcacattgat tccctcactt 120 ggaatgagac ctgaggattt ttggccagag tccaatcaac ttgcaaaaga caaccctatg 180 gacaacaatc tcgcttggat gtatcagctt gttgtcaagt ctaaagctct tagaaaaccc 240 ctcagtcgta gctacttcaa ccaggtagga aaggacgttc ccttatacaa tggagtggat 300 acgtggtttg aacgggtgaa tcagtacggt gaggaaaatg gtattgaagt tcatcattac 360 atcatatcgt ccgggctgaa ggagattatt gaaggaagta atatcgcccg gtatttcagc 420 cgcgtctatg catcgtcgta cctgtattct gcggatggtg ttgccgaatg gccagcacag 480 gccgtaaact ataccaataa gactcaattc atattccgga ttgccaaagg aatctttgaa 540 gagtacgatg agagagtaaa cgatagtgtg cctgagtctg cccttgttac tccatatgag 600 aatatcgtct atattggaga cagtgctaca gatatccctt gtatgcgcct tgtgaagagc 660 aagggcggtt attcaattgg tgttttcgac cctgaaaaga acaagcgtga gaaagtatat 720 caactgttca atgatggtcg aatcaatttt tatgctccgg ctgactactc cgaagattcc 780 gaactgttta agtatatcaa actagttatc ggacagattt ctattaacga aagagtcaaa 840 acagaacaac gaactctgaa aaattcggca gaggcataca atttatacat tactatgcaa 900 tcgttagcag accatatgaa gtctgctgtt tcccccagag agtaccagaa gcttcaacgg 960 gagcttaata agctccaaca tcaaatcgaa ggaatctaa 999 <210> 270 <211> 747 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(747) <223> BLCPAMOF_01911 <400> 270 gtgattttga tagaacaaga tgcaaagcgg ctgcttatgg aacggctgga cgagtgtttg 60 aaggttcatg cggatatgct ggatgcacag aacatcggca gtatttacga gttacaggga 120 ctttcggaac tccactatta tctgaaggtt gagcatgtat ttactccggc ggaagtagag 180 gcgcttcttt cttttcagga cccgttggat gtagcccgat ggtgttggga agaaaataac 240 catgaacaca gtttcccgat ctgcgatctt ctcaaagaaa ttgatgcagc gcaaaaattt 300 gaacatttca caagcgaacc ttccgcacag gacaaatata cgctcctgat gaaacggctg 360 ggacagaatt actttgctta cagggaaagc cttatgtcaa gagataagga atccttaatt 420 gaaaaagctg ctgaaattac agccatgcag gaggcgtatt cctatctgac aacaaagttt 480 gagttcaggg atgaaatgct ggatgatgtg ctggcgcttg agaatccttt gaaatacttt 540 gcagaccgtt ggcttatgcc ggtttcagat gtgttcgacg tggatatgga tattcgggaa 600 aatattgccg gaatccgaga cagccaggaa tacctgtgtc agagagagcc ggctgtttct 660 gtcctggcac ggctgcaaaa tgcggctcag gaagtgcggg aatgtccggc tgcggagaaa 720 gcggtacgcg attttggtgc acgctaa 747 <210> 271 <211> 141 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(141) <223> BLCPAMOF_02597 <400> 271 atgactacat cggaaattct attgcttttc cagacgatca tcgcactgtt ggcacttctc 60 gtaagtgtcg tacacttgat ggacgaccgg aaaaaggatg attcttatgg cagcaaaagg 120 aaaaagcaca aaaagaaatg a 141 <210> 272 <211> 1143 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1143) <223> BLCPAMOF_01038 <400> 272 atggcgatat atttagttgt gtttggactg tctacgcttt gcatttattt agctaaaaca 60 acaaagaata agagtataca gaaactcttg attataatag gattgttgct accggcgatt 120 cttgctggac ttagagctga aaacatagga gtagatgtaa aaagctatgc tatttcattt 180 tttgaaagag caaaacaaag tgatagcata atcaattttt tgaaaaacca atcaattctt 240 ggaaatgcag atataggatt taatttaata gtatatttgg ttgccaaagt agcaaatgat 300 tatcactgga gtttgtttgt ctacgaattg gtcgcagtaa cggtagtgta tatagctttt 360 tgcagatgtg agaagctgta tggaacacca gtgtggcttg tgatgctgtt gtattatttt 420 agtatgtaca atgtatcact gaatattatg agacaaacga ttgcggtcag ttttgttaca 480 ttggcagtta catatttgtt tgataaacaa tataaaccgt attttgttct tatggtaata 540 gcatttgcca tgcattcatc ggctatattg ggatttggca tatttccgat gtatctgttt 600 ttacaagata aacctggcac aagtgaaaaa aagcagtttc tcaaaggaat gtttgcagtt 660 gcagttgttg gtgcgatatc agtaacaatt aacaatcttg ttcggcttct ggttaatatg 720 ggaattttca gagaaaacta tcttaattac ttgagcggtg gtcagttttc aactgtatca 780 gaaggaagat caatttcact gattgttgcg ttaatacagg caacatatct gttgatattg 840 gttgtgcatt ttagatactt aaatagaaga aaaatgcaag ggctatttta tatatttgca 900 tctggtgtcg tctttatgtt tacagtatta ggtcctttgt ttgcagaata tatttcgagg 960 tcaagttatt tctttattcc attgcaaatg ataggattaa gtaatacata tacttgctat 1020 tcggaaaaat ctaaaaatat ttgggcatgg attttgattg ctatattatt cgcaacatgg 1080 tacagagctt atgtgctgtt gaattatgca gcaacagttc catatcaatt ttattgggac 1140 taa 1143 <210> 273 <211> 891 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(891) <223> BLCPAMOF_02292 <400> 273 gtgactactt atctaagcat ttttacggac accaaatctt gcatgcaaaa atgcgaaatc 60 tgctttgaaa tggggtattt gcttatgttt aaaatcaaca atctggcaaa tcagacaagt 120 cacatcgtca ccgaacagaa gggtatcttc tccattgttg agcacaatgt cgatttctcc 180 gtagcgcctt gcaatgcaat ggaagaatac tatatgagcc agatgaatgt caaacggaaa 240 caggccattg ccaatctcaa cggaaaagtt gggcttgttc tccaagcggg cgcaatgcag 300 tacattgttg gcaacgtgca agcaaccacc gggttgaaag gtgttggtga cttcttaggc 360 aaaatggtaa aaagttccgt cacaaaagaa agcgcaatca agccggagta cgtcggaacg 420 ggtgtgctcg tgaccgaacc cacctataaa tatcttctga ccgaaaatgt cggtgactgg 480 acaggcggtc ttgtaatgga agacggcatg ttcctggcct gtgaatccac tgtcaagcac 540 gagattcagg cacgctcctc gctttcttct gcagcactcg gaaatgaagg actcttcaat 600 ctacggcttg ctggcaatgg tgtatgtgta ctggaaagca atgttccccg ttcggaaatc 660 gtagaaatcg cccttcaaga cgacgtttta aaaattgatg gcagctttgc gatttgctgg 720 tccggcagtc tcagctttac ggttgaacgt tccggaaaaa ccttgcttgg ttctgccgca 780 tccggtgagg gtctggtaaa tgtttataag ggaactggca aagtatggct tgctccatta 840 acgccttctc aatcactggt tagcgcaacg catgcaaaaa gtgcaaagta a 891 <210> 274 <211> 699 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(699) <223> BLCPAMOF_02291 <400> 274 atggagaaac tggaagcgaa gctgaaagca gtggactggg ccgtgcggga tgtactggtg 60 ggtactatgc gcagcccgca gcagctggat atttgccgga agcactgctt ttattacatc 120 ccggcagagc gcctgcagga cagcagtttt cctatccgct atgtggccct ttaccagtca 180 cagtatgtgt tcggcgcaca ggcaggtgtc cggtactacg gcgaagtcac gaaatgcagc 240 gccgtccgcc ggagcgctat cacagaaatc gacccccgga gaggaacgga agaaaacctt 300 tattaccgct tcgacatccg gaaatggaag cagctgaacc ggcccatcga ggccaaagaa 360 acgggctttg taagggattt taccaacctg ttcctgctgg agcacagtat ccggacgccg 420 gaactctggc tccgcacgga agaggaatac cgcctttgtt cggccctgaa gcgggccgtc 480 tggggcgaca ccatcaacga accggacaac ggccttgcgt ttgaattccg gggcttcacc 540 gtaagctttg cggaggggaa aattttcgtt tcagacgaag gccgcgcttt tgcgcggtat 600 gagatctcgc attttttgca ggatcccggc gctgtggtcc ggggcatccg aagagaatgc 660 ctccagaggg attccatgag ggaactctcg aagatttga 699 <210> 275 <211> 561 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(561) <223> BLCPAMOF_01837 <400> 275 atgtccgata ttaccatccg taacgccaca ttggccgacg caccccgcat tctggaaatc 60 tacgcctact acatcgagca cacggtcatc actttcgagt acgatgtgcc gtcgcttgcc 120 gagttcgagg accggatgcg ggacatcatg aaaaaatacc cctacctcgt cattgagcgg 180 gatggccgca tcgagggcta ctcctatgcc cacgcttttg tgggacgtgc cgcctacgac 240 tgggccgcag agctgaccat ctacctcgac cacgacgcca ggcgcggcgg actgggccac 300 gtcctctatg aggcgctggc cgaccggctc aaggccatgg gtgtcctcaa cctctacgcc 360 tgcatcggct acccacaggt ggaggacgaa tacctcacca aaaacagtgc ccagttccac 420 gaacatctgg gcttcacgct ggccggtacc ttccacaact gcggctataa gttcgggcgc 480 tggtacgaca tgatctggat ggaaaaaatc atcggcgagc accgccccga tcagccggac 540 atcgtgccgt atcaatattg a 561 <210> 276 <211> 384 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(384) <223> BLCPAMOF_01830 <400> 276 atgaaaatcg agcacatcgc cctgtacgtc aacgacctcg aagccgcaaa ggacttcttt 60 gtgcgctatt ttgacgccgt gccgaatgcg ggctacaaca acccgcggac ggacttccgc 120 tcctactttc tcactttcgc ggacggcgca cgcctggagc tgatgaacaa acctgggatg 180 cccgacgagc cgaagcctgc cgcccgcgcc ggatacgcgc acatcgcgtt cagcgtcggc 240 agtcaggaaa aggtggatgc gctgacggcc cgcctcaagg ccgacggctg cgaagtcctc 300 agtggccccc gcaccaccgg agacggctat tatgaaagct gtgtccttgc ggtggaagga 360 aatcagatcg agataacggt gtaa 384 <210> 277 <211> 2292 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2292) <223> BLCPAMOF_01285 <400> 277 atgaacagcc aaaataagga actatctttt cgtataagtt ccggcttgaa aaaccttatt 60 ggtcgtgact taattagtga tagatatata gccgtatttg aactggttaa aaattcttat 120 gatgccggag caagtaaagc tacaatttcc tttgaacagt ctgacgatgg aacggaaaga 180 attattattt cggacaatgg ttgcggaatg acatacgcag acattattaa caaatggttg 240 tttgtggcat attcggaaaa gaagcctcaa catcgtcaac agtcttcctt tcgagataaa 300 attaaacggg aagtagcggg agcaaagggc gtaggtcgtt tttcttgtga tcgcctcggt 360 gcactattaa ccttagtaac taaaacagaa caagataaat acgctaatag agtagaagta 420 aactggaata catttgaatt agatgataca gaagaatttg tgaacatacc agttcattat 480 tccattactg aagaccttcc tggtggcttt aaaagtggta ctacgctgat tatagagcaa 540 ttacgggaag aatgggatcg tgatgcgctc ttgcgcttaa agcgatccct aatgaagctt 600 attagccctg atgctaatga aggagaactc ccatttgata ttgaacttat tgtcgaatca 660 gaacgtgaaa atgatgacaa aactttaaag aaaacaggaa taaatccaga cagagacata 720 gttaatggaa taatccataa tgacattttt gaaaaactaa acattaaaac gacttgcatt 780 gaagtaaata tatcacctga tggggaattg atttctagca agctaacaga tagaggcgag 840 tacattttct cggttgttga gcgtaatcgt caatatcgtg aattgcaaga tattagcatc 900 gtcgtttttt atttaaatca aagtgcaaaa gtaagtttta ctcgccaaat gggaggcgta 960 actcctaaaa gttatggatc ggtttttatt tataaaaatg gtttccgtat taacccatat 1020 ggagatccag gacaagactt ttttggcatt gatcagagaa aagctcaggg atggcgccgc 1080 tttttaggaa ctcgagaaat aatggggcgg atttcaatta agggcgagaa cgatcaattt 1140 gttgaaacaa ctagtagagc gcatggcttt attcgtacta aagcagttga aagtctaaca 1200 acctttttta ttgaaaaggt tttaaaagtt ctggaaaaat atgttgtaaa tttaattgga 1260 tggggtgagc cattaaaaag tgaccccaca catactattt cccctgagga agtaggagaa 1320 caaattatat cccaatttat aaccagcatt gattctaagg atattgttcg tattgattat 1380 aatccagctc tactatcaag aaatgacgaa aagcaagaaa gccttaccac ctcattaaaa 1440 aagcttgaga gtgcagctga gcaggcaaat gacgaagggc ttataagttt agctcagaat 1500 ttaaaaaggc gaacagaagc tatagtttct caaaatctcg aattggaaga agaaaatgca 1560 gttcaagaga gaaaactagc taaggcgtat cgtgaagggc aggcaagaga aaaacaaatt 1620 tattttcttc aaggcagtgc caatcaaaat gttactaatt tgattaacgg ttttcactca 1680 atatatactc ttacagatgc ttcgaaagga tatattaact atttgcgcga aatattagca 1740 cccatagaac ttgaaaacaa agattttgtg ctatccatta ttggccaaat ttatcaagca 1800 aacgaaaagg cccataagct atctgattta gctatacatg gaaatcaatc attgaagcag 1860 agtggagtaa acagcgtata tgattttatt cgccaatata ttgatgaagg acttacaatg 1920 cagggactta aatatgattt agttccttca aatgaggcgt ttaattgcaa attcgatgct 1980 tcttcaatcg gagttattat tgacaatatt gcaagcaatt caataaaagc aggtgcgacc 2040 gtcctacaaa ttaagatgtc tgaaacggcg aaatatgttg aaatagtatt ttctgacaac 2100 ggcattggtc ttgatgagag tattgaccca tccaccttat ttgagtgggg attctcttcc 2160 aatgtaaaga aaaaaggatt tggtatcgga ctttaccata ttaaacagct catagatgaa 2220 atgaagggct ccgtcaatat tgatacttcc tatcacgatg gttttagatt ggttgtgagg 2280 ttaaaaaaat ga 2292 <210> 278 <211> 930 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(930) <223> BLCPAMOF_01286 <400> 278 atgaacacta catttaaaat attatggttt gaagatgagc ctgcttggtt taatatggaa 60 aagttgcgga ttgaagaaat tctaagaaca cactatctca ttccggttat cgaacggaga 120 gatggtgatg attttgattt agaggagcta accggtaacg actatgactt gattttcatg 180 gattataaat tagcagaagg aaaaaccggc gatactattg ttgctgctat aagaaatagc 240 tacattttaa ctgacattct gttttattca tctgaagaac agaatatgct atcggctatt 300 agaaagcaga tgcctcctat tgatggtgtt tatcttacaa agcgcgacta cagaattttt 360 acagagaagg ccgaaaggat catacaaaag attgttaagc gctcagaaga tgttgttaat 420 ctgcgtggct ttgtcttaga taacactagt gcttttgagg tacggataag agaaattctc 480 aatatttgtt ggcagaagtt taaaccagag cacaaggtcg ttttatctga agcgattgag 540 aaacagttgg aaaataaaag tgctcgggtt gaaacgcaga taaaagctgc caaaggtgct 600 gaatgtacgt ttacttatgc caataataat ccgtatacct tgagtgtagc tgatagactt 660 gatattcttc aagctgttct gccgatttta aatgaaacat atcagatgcc aattactact 720 gtgccacatg attttaagca atattatctt gataaagtaa acgtgtatcg caacaaacta 780 ggccatatca cccttggtga gaaaattatt cgcgtcaatg gacaagatgt ggaaattaat 840 caagatcttc atagactgtt gcgaagaaat atttcagaag ttgatgctac catccagcaa 900 cttgaaatgt atctcaccaa tcatatataa 930 <210> 279 <211> 453 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(453) <223> BLCPAMOF_01913 <400> 279 atgagtaaaa ccaatacaga aaaaatggcg ccggagacac agacgccgga aatggcaaac 60 ggcatgaagc tggatgtccg cgtgcgtccg attgccccaa tgggaaacct gctggcgttt 120 gccaatgtta cgattggcgg atgctttaag attgacggct tccgtatctg ttccagtgaa 180 aaggggctgt atgtcaatat gcccgcaacc caggataagg gaggcaactg gaaagatgtc 240 tgctggccgg ttacggcaga gttccgcaag cagctcaacg atgccttaat cgatgggtac 300 gggcaggcta ttgaaaattt gcaggcaact cttgaagcga caaagggagc agcggaaaaa 360 ccttccctga ccggtgcatt gaaagaaaat gccggtaagg tcaaagaaca gccggccaaa 420 ccggccacat ctaagaatga gcaggctcgc taa 453 <210> 280 <211> 816 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(816) <223> BLCPAMOF_01918 <400> 280 atgttaatgg cagtaaatga accttatgcc cttatggtgc agccggacga tattctgatc 60 tctccccgtg aggtagatga acattttggg acgatggtat gcttccatcc ccgctatgcg 120 ctgggcgacc atcacaacta tatggacaaa gacgacttcc tgcgggaaat gtatttagat 180 accgtaggac atgatgaagc cggcatgaaa cgctatgaac ggatggtaaa cattgtaagc 240 agccgtttcc ggcatggacc aaagacagag gaacgggcga tcgatgaagc aatgcagaaa 300 gtaatttcgg aaaagtatct gatgctcccc ctctatctct acgaccactc aggtcttgcc 360 atgagtacag aaagtttctc aggcagggcc cctcatgcag aatgggacag cggacaggtc 420 ggctggatct atgtttccaa agaagatgcc ctaaaggaat ttgacgctga caagatgacc 480 ggcgccatcc ggcagaaagc ggacgcactg atgcgcagtg aagtcgccgc ttacgattcc 540 tatctgcatg gcgaatgtta tgggtttgag ctttataaaa acggggagct gtcggatagc 600 tgctggggct ttatgggtaa cttttccgat gtgttgaaag atatggcgga atacctcccg 660 gatgagtgca aagggatggt cgatcatctg gaggaacagg aacgcccggc tacgatcatc 720 aagacgcttt tgaaacatgc taaaattcag gtcgatcagg cagcaaaagc ctttgaacac 780 gcttcccgac agcaggttct tggggaaagc cggtaa 816 <210> 281 <211> 510 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(510) <223> BLCPAMOF_01944 <400> 281 atgaaaatag cgatacttgg taccagcggc agcgggaaat ccacgctggc aaagcgcctg 60 ggggagagat acggcctgcc ggtgctccat atggataccg tgcatttcct gcccggctgg 120 gtggagcggc ccttcgccga ggaagaagcc attgtccggc agtttctcga cgagaacgca 180 ggcggctggg tcatcgacgg caattatagc aagacctgct atgcccgtcg gctgaaagaa 240 gcggataaaa tcatcgtgct ctggttttca ccgctggtct gcctttggcg ggcgatacgg 300 cgctggcagc agaacaaagg ccgtgtgagg gagtcgtctg cgcccgggtg tgaagagaag 360 atagatgccg aatttgtccg ctggatcctc cacgatgggc gtacaaagca aaagtgggcg 420 aagatggaga agatcgggga aaagtacccg gagaaatatg tattgattcg gaaccagcgg 480 gagctggatg ggttcttgaa gaaactttga 510 <210> 282 <211> 192 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(192) <223> BLCPAMOF_01288 <400> 282 atgattgatg gggtcatcaa caatggccgc aagggtgagg agctggaggc ggcaaagggt 60 gaggcgcgcc ggacctcccc ggagaaaaag ccctctatcc gggaacggct ggaggaggcc 120 aaaaaggagt gcggcgagcg caagcccccg gacaaagctc accagaagaa gcccccggag 180 cacgacctat ga 192 <210> 283 <211> 90 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(90) <223> BLCPAMOF_01617 <400> 283 atgtgtgatg tgcttgataa agtggaaaac agaggcatcg tgaaaggtga gagccgtgct 60 gagctgatga aagagcttgg aatcaactga 90 <210> 284 <211> 825 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(825) <223> BLCPAMOF_00031 <400> 284 atgaaaaagt ttcttctcgc tcttctgaca gctgtcacgg cggctgcgtt cttctgtggc 60 gcggcagcat ctgtggccac ttacagcgcc agctatgacg caccggccgg catcaacgcc 120 atcgtggtgc aggacaacag cgctgcggtc attctgcagg ccgccgacat cgaccacatc 180 cgcgccgatt acacctacac ctcgagctac gcctttgaaa gctccaagct ctacgacttc 240 acggtggcgg gcagcaccct caccgtgacc aagacccggg agcccaacgc ttcccttatc 300 atccagagcc aggacacccg cagctgcacc ctgacgctgc aggtaccccg ccagacgctg 360 gcaaacatca ccgtcagcac caccaacgac agcatcacgc tggacggcat ttcggcacag 420 accgccagcc tcaccactga caatggccgc atcgaggtat cgaacttcaa cggttccacc 480 ctgagcggca ccacccgcaa cggcaagatc accatgagcg gcgtcacctc ccagaatgtg 540 gctgccacca tccagaacag cggcaccctc aagctggaaa acatctctgc caacgtctgc 600 aacgctaagg tgcagaacgg ctgcatcacc ggctctgtga tcggcagcgg cagctcttac 660 ggctttgagc tggccgcagg cggcggcaag atccgcgtct ccgacgccag cgacaagaac 720 ttcctcttct tcggcaagga cactctgcag cagaatgcag atgcccccaa caagctgaac 780 ctcgccacca agaacggcga cgttgaggtc gagttcgtcc gttaa 825 <210> 285 <211> 270 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(270) <223> BLCPAMOF_01615 <400> 285 gtgaagtacg gcggcgaaga cctggatgcc ttcaccgagc gggtatacgg ggccgtgaag 60 gacatcgccg aacacacggc aggggagtgc atccttatcg tctcccacgg catggccatc 120 cggcgctttt tgactgaatt cccggaaaag gcgggcgagg tcaccgattt tatcggcaac 180 tgcggcgtcc tcgagatgac atatgcagac ggaaagctga cggtagaaaa aatcatcgac 240 ccgaacggct atctgaaagg cgcgggctga 270 <210> 286 <211> 219 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(219) <223> BLCPAMOF_02579 <400> 286 atgtgtgatg tgcttgataa agtggaaagc agaggcattg aaaaaggcat tgcaaaaggc 60 gttgcgaaag gtaaggctga gggtgaaatt gaaggcaaaa atcaaatggc tctccttgtc 120 aagaaactcc tcaatcaagg ccgtattgat gatgtcaagc gggcatctga agatgaagtg 180 taccgcgatc agttgataaa agaatttggc attcgataa 219 <210> 287 <211> 453 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(453) <223> BLCPAMOF_00039 <400> 287 atgtgctgtc ccttccacgg ggataaacac cccagcatga aggtggacag ccgtttccac 60 tgtttcgcct gtcaggcaga tggcgatgtg atcgattttg tcggcagact ttttcaactt 120 tctccctata aggctgtgga aaagttgaag gaggacttcg gcatggcact tgccgacggc 180 aaggtgcggc ttgctccccg cagaccgccc accgtccggc agcagctgct ggactattac 240 cgctgtctgc agcgttggcg ggtccgatat gcaccgcagt cacccacaga agaacttcac 300 ccctgctttc ttgaagcgat aaagaacctt gacatcgttg aatattatct ggactgttcg 360 gtgctcccgg acccgcagac cgaaaacgaa ctacggaagt attgggaggg attgcatgag 420 cgactggaaa aagaggaacg acgattggcg tga 453 <210> 288 <211> 279 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(279) <223> BLCPAMOF_01207 <400> 288 atgaaactca agaatgtttg tgttaccgtt gctgctctgg tcctggctgt cagcatgact 60 gcctgcggca gctcttcttc tactgctgct tctacctctg aggctgcttc tgctgccgct 120 cagtctgagg ctgcttccac ctctgccgtg gccgaggaga actctgcttc ctctgaggcc 180 gcttctgagg tgagctctga ggctgcttct gaggtttcca gcgaggccgc atcttctgag 240 gctgcttcct ccgaggccgc ttcttccact gccgcctga 279 <210> 289 <211> 207 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(207) <223> BLCPAMOF_00507 <400> 289 atgaaaaaca aacccgctcc cctgctgaac cccggcaccc tcaagcccat gacggccagg 60 gagctggacg gcgttttctg cgatgagctg gtacagcagg agctggacga caccacggcc 120 tacatcctca gccagctcta ccacgacggc ctgatggagg ccaccggcgt ggagcagacc 180 agcgtctttg aggcagcaga gcactga 207 <210> 290 <211> 201 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(201) <223> BLCPAMOF_00337 <400> 290 ttgcaactct attatatcca cctgctgggc atcgactaca ccccggtgca gtacgccttc 60 ctcgttgtgc tggctgtggt cgtctccatc ggtaccgtcg gagctgccgc cgctaccacc 120 cttgtggctg ccaccgaagg ccagctggac aaggctgtat acaatggcga ggtcgaagta 180 cctgctgccg aggcagtctg a 201 <210> 291 <211> 957 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(957) <223> BLCPAMOF_01040 <400> 291 atgattcaag acgcagggtt tcacaaggca acgaccattc ttacagaatg gatttattcg 60 tttcatatgc ctgcatattt ttgcttatcc ggtactgtgt tttcgatgga attaaaaaag 120 aatcgctatt cgtctgtcag caatctgatt agggaaaagg caaaaagact tttgattccg 180 ttactgtttg tatggcttgt ctggaacata ccaattaaaa tgttggcagg gtattatgat 240 ggtttagctc acccgctaat gatggctgtg attcagataa tatttccaaa tgcagtttat 300 ctatggtttt tggaagcact gtttttctgc tttgttatgg attatgtgat tgaaaagcac 360 atcaaaaatg tgggacaaca gttcatgctt gttggaacat tggcattgat agggttgggc 420 ttttataaat atgcacgtca aattgctcct tttggtaatc cgttccgatg gctgatttgg 480 ttttggatag gacattttat tgacaatatt ctaaatgaac taaataaggt atcggaaaac 540 catgggttta ggtcggaagg acaggctttt gtggtagaaa catttttgtt tgcacttctg 600 tatgaaatca gcttttgtac tgcatcaata agatggattt taataaatac cgtaatacca 660 tttattggaa ttgtatggat ttgggagttt gccagaataa ttgaaaatgt attaaggaaa 720 gaacatcata aaaaacttct tgctatttcg caaaatacgt atggagttta tttgtgggca 780 gagccattaa attatttggt tctttcatgt gcaatgaaat ggtttggtat cagtgtattt 840 ggaacggaga tgggggcagc tttgatttat attgttcgtg tcgttggaac agttgcaatt 900 tccgtcctta taataaatgt gctaagaaag attaggtgtc cgataaaagc atattga 957 <210> 292 <211> 483 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(483) <223> BLCPAMOF_01904 <400> 292 atggtaaata ccatgatttc cattcccggc tatgtccatc tttaccgctc acttttgcgg 60 ttttacgaca tgccggaaaa tgaagtccgg gaaatgctct atcttctgaa tacggcaaac 120 ctggactgct acgagtatta tcacccggac cgcagtgtga tccagagcgg accggtcgct 180 ttttgcggat ggctggaaac gaaagactgc cgcccttacc gcacagaggt acagctttac 240 aagtcgctgc tgtttttgaa gcgcagcatt gaccgtgacc tgatcgtatc agctcagagg 300 gaggctctgc aaaccctgcg ctgtatcatc tccaatctgg aataccgctt ttataaagcc 360 tatggcatgg agatcgagga caaacgcacg gtctatgggg aatgtaccta ccgtctggtt 420 ccaagggagg acgaacccag cgtgtgcctg atgcacgact ggatctacct gccgagtgct 480 taa 483 <210> 293 <211> 618 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(618) <223> BLCPAMOF_01903 <400> 293 atggcaaatg gctattccaa acagattcag gagcagataa aagcagcggc ggaaggaact 60 attttcatca gttctgattt tgcggatatt gccgatacgg aaaccataag acggaactta 120 aaccggctta cacaggcagg tatgcttcgc cgcattttga aaggtgttta tgaaaaacca 180 aaatatagca aacttctgga tgaatatgtg gcggcagacc cggaagcggt ggcgaacgca 240 ttggcacgaa gttatcactg gacgattgcc ccatgtggga atacagcatt gaacctgtta 300 ggtctttcaa cacaggtaac agcagtatgg tcctatatca gcgatggtcc atataagacc 360 tacgagtgga actctacaaa gctggaattt aagcaccgga ccaataagga gattaccgga 420 ttgtcctata tgacaagttt ggttatacag gcattaaaaa cgcttggcaa atcgaatgtt 480 acgccagaag tcatacagat gctttccgaa aaactgacag acaaggataa acaggcttgt 540 ttgaaggaag caacagagtc tacggattgg gtttacgata cgatacgaca gatttgtgga 600 ggtgaaaagg tacaatga 618 <210> 294 <211> 1401 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1401) <223> BLCPAMOF_00592 <400> 294 atggaaacga aaaagaagca attcaagatg ccgcatacct tcgtcatcat cggcatcatc 60 atcctgtttg cggtcctgct gacctggatc atcccggcag gctcctacac ccgcttcgag 120 aacgaagcag gcattaaggt catcgacccc aacgatttca actacattga taagactccc 180 gtcaacccgc tcgaaattcc tctgtacatc gtcaatgcct tcatcaagcg cattgatctg 240 atgctggtca tcatgttcgc aggcggtgcc ttccacatcc tgaccaagac cggcgcactc 300 cacgccgtgg ttgccaagat ggcaaagatc ttctccaccc gcatctatct gttcctgcct 360 atcctgacgc tggtcttcgg cctcatctgc accacgcaag gcgtcaacct gttcattgcc 420 tttgcaccga tcatggtcat gatggctttt gcgatgggtc tggactccat caccggtgca 480 tccatcatcc tgctgggcgg cgctatcggt ttctccactg gccctctgaa catcaacacc 540 accatcgtgg ctcagaaaat tgccgggctg ccgctgtatt ccggcgtggg ataccgcttt 600 atctgctttg ctgtgttcta tgttatcacg aacatctacc tcatccgcta cgcactgaag 660 atccagaagc atcctgaact cagccccatg tacgagatcg acaagaccag cgagttccgc 720 aatgctgctg acctcgactc cttcggcaag ctggacgccc gcaagatcct cattatgctg 780 gtcttcttcg catcccttat cctcatcgtc tacggcggca tcaagctcga ctgggatatg 840 gctgagaccg cagctgtctt cctcgcactg gctgtcatcg aaggcgtact gggcggcttt 900 ggtccctctg cgatttccaa agagttcctt gagggctgca agaagatgct gggcgctgcc 960 tttatcatcg gcatggcaca ggctatcagc agcatcatga acgccggcca catcaccgat 1020 actgttgtcc acgcactggc aaacggcctg aacttcgtcc ccaccatcct gctcggaccc 1080 gccatgctgc tggcaaacac cattatcaac gtcttcctga cttccggcag cggtcaggca 1140 gcagctgtca ttcccattct ggcacctctg gccgacctcg tgggcgttac ccgtcagacc 1200 gcaattcttt ccttcaactt cggcgacggc ttctgcaact acgtcctgcc cacttctacc 1260 gctctgatgg gtatcatcag cgctgtgaac attccctatg accgttggat gaagttcatg 1320 tggaagctgt tcctcatctg gatggccgtt ggttctgtgc tgctgatgat cgcacaggca 1380 atccacctcg gccccatgtg a 1401 <210> 295 <211> 840 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(840) <223> BLCPAMOF_02054 <400> 295 atgttcgaag aattctatga gatgtatgag accgaggagc aggaagtggt cgctctgatc 60 aatcgctgca tcggaggcgg atttaactgg aaaggcaact tttgggaaat gaccgttgtg 120 acgctgggcg tggtattttg tgacaccggc aaggtcagca ccaaagagga gcggctggag 180 tggccggtca ccgatgagga gcgtaacagc gaaaagggct gggaacgctt tcaaaacgag 240 cagatctgcc gcctgaagat ccgccagatg aaagaggaat gggcaaaaga tctggtggca 300 tggccctggt gtatctccca ggtggtcaag gcccacgagg actgtccgga acttcaagcc 360 gttctggacg agtaccacaa gccggtggtg atccaggacc aggtgctggg tgaactgaag 420 ctggacaagg actatgatac cttcgaggga gaaatccagt ggtgcggaaa ggatgtgctc 480 ctttctctgg aggtcaatgc tgaaagcaag ccctcctgga cccgcgcccg cagtgccgcc 540 aagaagctgc tggccgactg tgaaacctgg gacaaagcca tgcgggagct tgcagccaag 600 aacctgaccg agctggccga caactggctt tctcaagatg aggaaaatcc ccgcaatccg 660 aaaacagacc ctatcacaga ggaagaactt gcccgacgaa tcagcatgac gagcctgtcc 720 gtcacctccg gcggcagctt cacagcctgg tttgactgcg atgagatgtt caccgaccat 780 gcggtgactg tctacggctc cttgaaaaag ggcctcaaaa ctgccaacat tgaggggtaa 840 <210> 296 <211> 654 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(654) <223> BLCPAMOF_01848 <400> 296 atgtatttcc aatacggcga agcggaaacg gcgtatctga gcgcaaaaga cgagcggatg 60 gcggcggtca tcgcacaggc gggacacatc gagagggaag tggataccga cctcttttcg 120 gcggtggtac accacatcgt cggccagcag atctccacga aagcgcaggc gaccatctgg 180 aagcggatgc gggacgagtt cggcgtggtg gatgcagctg ccgtcctcgg agccggggtt 240 gagaagctgc agagcttcgg tatgaccttc cgaaaggctg aatacattac ggactttgcc 300 cggaaaatcg agagcggaga atttgacctc gagggtatcc ggcagaggcc ggacgatgag 360 gccatccggg agctgagcgg cctgaaaggc gtcggtgtct ggacggcaga gatgatattg 420 ctcttctgta tgcagcggcc cgacgtgttc agctacgacg accttgccat ccagcgtggg 480 ctgcggatgg tgtaccacca ccgaaaaatc gaccggaaac tgttcgaaaa gtaccgccgc 540 cggttcagtc cctattgcag cgtggccagc ctctacctct gggcggcagc aggcggcgcg 600 gtgccgggtc tcaaggacta cgcgccggct caaaagccga aaaggaaggg gtga 654 <210> 297 <211> 213 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(213) <223> BLCPAMOF_02057 <400> 297 atgacccaag aagaacagat ccgactctat cggctgatgg aaaaactcaa ctggtttttc 60 caccaagaga tgcactacct gaatagagat attgcggaaa agaccgcacg ggagtgttac 120 ccggagattc gggattttac atacgatatt ttgtggaatg acctgcccag agaggtgcag 180 ggacaactta tgaacgagga tgagacgcta tga 213 <210> 298 <211> 270 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(270) <223> BLCPAMOF_02721 <400> 298 atgcgacagg aaacacaatg gacgacgatc ttctgggagg gctggacggc gctggcgctc 60 tgcgcagcgg cagtgttctg gcccggcagt gcggcgctgg gctatccggc tgtgctctgg 120 ccggggctgg cccttgcggc ggcagtcccc gtcctctggg ccgggtggtg gctctgggcg 180 gagaaggccc cgccgctgac ggaggaggag ctgatggcga aaccggggag gatacatatc 240 gagaaggaag aagtagaact ttccgcctga 270 <210> 299 <211> 3759 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(3759) <223> BLCPAMOF_00933 <400> 299 atgaagacca gtaaccatct gctgcgccgc ctgacggctg cgcttctggc cgctgtgctg 60 gcgctgagca tcgcactgcc agtgttcgca tctgacgacg gcgataccat ttacatcaac 120 agcgtctcgg acctgctttc gctggccaag agctgtgcct acgaccagtg gtcggtgggc 180 aagacggtta ttctacagaa agacctctcc ctcgagggga tgctgtggga gcccatcccg 240 tccttcagcg gacagttcaa gggcaatggc cacaccatct cggacctgac cattacgggc 300 cagtattccc cggcgggcct cttcggcatc gtggaggaac agggctccat cgagtccctg 360 agcgtgcggg gcatcgtgtc tgtctctgac gctgccgaca ccaccaccgg cggcatcgta 420 ggcatcaacc acggtaccct catcaactgc cagttcaccg gcgtcgtcac cggcgacagc 480 gaggtgggcg gcatcgtggg ccgcaacgag tccgaaggca ccatcgacca cagcacggcc 540 cgcgccatcg tcaccggcaa atcttccacc ggcggcatcg caggctacaa cctcggcgcc 600 atcaccggct gcaccaacgt gggcagcatc aacaccgaat atcaggaagc ctctctcgac 660 accgacggct tcaccgccaa gatggtggac cagatcaaca acaagatagc cgccgccgat 720 gacgacgcca ccaattccgt caccaacgtc gccaccgaca ccggcggcat cgcaggccgc 780 tcctccggca tgatcctgac cagcgtcaac accggaactg tcggctacga gcatatcggc 840 tacaacgtgg gcggcatcgt gggccgcacc gacggcctcg tatccggttg tgtcaatcag 900 ggccatgttc tgggccgcaa ggacgtggga ggcatcgccg gtcaggcgga accctatcgc 960 gaactcgacc tctctaagga caccatcaag cgtctccgtt cggagctgga tgttctgcgc 1020 ggccttgtcg atgacaccac cggcgttgtc gagaactcca ccaccagcat ctccaattcc 1080 ttcagcgcca tgaccagcca gatggacacc gccattgcag cggcacgcca gctggacgat 1140 caggccagcg actacggcga cgaggtggcc gacgagatcg accgcgcctc cactctgctg 1200 gccgataccc tcaccaaact cgaacccgtc atggacaccg gcgaagatgc catgaccaag 1260 ctgaccgatg ccaccggaaa cctcaagtgg gccatgcgcg agatggccgc tgagatgctg 1320 atggcatcca gcgccctcag caagaccagc tccggtctgg gcaaggtgag cgacgcggcc 1380 gaggatggcc gtgacgggat gtcggctatc tctgagggta tcaaacagct gttggagtct 1440 gtcgataccg gcgatgacag cgctgcctcg caggcgatct ccaccatcct gaccggctac 1500 gactctctct ctgccgagaa gaagtccgac aagaacctca ggaccggcat tgagctgctg 1560 aaggtggcca actccgtggc cagcgtcttc acgctgggca gcggcatggc cccggcaatg 1620 aaggctgtta ccgcaggcat gggcctgctg cgcacggcgt ccctcctgtc caacgacagt 1680 gacattgccc gtgctacttc ccaaatcgca agtgccatcg gcaccatctc taccattgcc 1740 acccagatgg gcggcatcgt gggcagcgct gccaagtccg tctcggcctc cgaccacccc 1800 gagctggctg cggctctgac caaagcctct gacgcgctgg acggcatggg cagcatcacc 1860 gacggcatca tggacaacat caaggactgg gtcggcaata atggcggcgg cagcatcaag 1920 gacggtctcg atcagctgag cgatgcttcc gacaagctga gcgacgctat ggatgacctg 1980 agcgactccc tcgacctgct caagaccgac gccgccctca ccagcgcaac gctggcgcat 2040 acctccgtgg ctctgggcca gatgcaggac ggcctcggcg gcctgaccga tatgatgggc 2100 cagacccgcg atattctcca ctggctcaac cagcaggacc ctatcaaggt gcctcgtccc 2160 tcggcagagc tgaccaacac caaggactcc ctctttgatg ctgtcagcgc catcaacgac 2220 aagatggacg acatcaacag caccatgcgc accgccagca accagctgac cgacaagatg 2280 cgcgccgtga ccgcacaggt cagcgttgtg tccaacctga tgctggatgc tgtggaagag 2340 atcagcgacc cgggcagcaa gaccatctac gaggatgagt cggaagacct catcgcttcc 2400 cagtccgacg gcaaaattga aaacagcatc aaccgcggca gcatcgacgc cgacatgaac 2460 gtgggcggca tcgccggtac catgggcgtc gaaaacctgc tggaccccga ggaggacaac 2520 aaggacgagg gtacctcgct gctgcgcacc tcctataccg tcagcgccgt cctcaccggc 2580 aacatcaacg agggcagcat caccgccaag aaggatatgg tcggcggcat cgtcggccag 2640 gaggagctgg gccttgtgac ggcctgcgag tcctacggcg acgtcaccgg cgtcaatcag 2700 gtgggcggca ttgccggtgc ggccagcgcc aagctccgca gcaactgggc aaaatgcgcc 2760 ctcagtggtg aaaagtacat cggcggcatc gtcggtcagg gtaccgacag cgacctcacc 2820 gacggcagcc tcatcgccat caacaaccgc gccatcgtct ctgtgctgga aggccagcag 2880 tacgtgggtg ctgtctccgg cggacaggac ggcgacttct atggcaacct cttcgtctcc 2940 gacgatctgc agggcatcga ccgcctgagc cgcgtcggtc aggcagagcc ggtcacctat 3000 gagaccctgc tggctcagga gaatgtgccg gactccttcc gcaagctgaa cctgaccttc 3060 aaggccgacg gccacatcat caagaagatc agctttgact acggtgcgtc cttcactctg 3120 gccgactacc ccgagatccc ccagaaggat ggatactacg ccgagtggag cacacccgtt 3180 ctcgaccagc tccacaccga caccgtggtc aatgtggagt acacgcccta catcccgtct 3240 ctgagcagca gcgtcacccg cgagaacgga cgccccgttt tcttcgtgga cggcttcttc 3300 ggcggttcca acgccgtgca ggtcacccag caggacatca cagccgatgt ccacggtgtg 3360 acagagcagt ggctgctgga gttcaccgat gacggcaatg agacccacca gatccgttat 3420 ctgacccccg gcaaggccaa gggcaaggtc tacgtcaagc aggccgacgg cagctggcat 3480 aaggtggaga cgggcagctt cggcagctat accaccttca ccaccaccgg caccgaggtc 3540 gaagtggctt tcgttcctgc aaagcttccc atctgggcct tctgcgccgg cggcgcagcc 3600 ctgctggtgc tgctcctgct gctggcaaag cgcatcaagt cgaagcgcgg ccccaagggc 3660 gaaaagcccc gcagggagaa gaagggcaaa cagcccgaga tggcggacgc cccggccgat 3720 gagctggata cccccatctc tgagacggat atgcagtaa 3759 <210> 300 <211> 2478 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2478) <223> BLCPAMOF_00932 <400> 300 ttgaacgaac acgaaaaacc gcagatagac ttcatgcaca agcttgcgcg ccagatcgtg 60 gaacgccgca accttgtgtt cctgtttgtc attctggctg ccatcttcac ggtgttctcg 120 gtgcggtggg tcaaggtcga gaccgatatg accacctacc tgcccaagac ctcggagacc 180 cgcatgggcc ttgacatcat ggacgagcag ttcacgacct acggctctgc cgacgtcatg 240 gtggccaaca tcacgcccac tgaggccgat gagctttccg acaggctcac cgagctcaag 300 ggcgtccaga tgctggacta cgacgacacg accgaccatt ataataagga ctcggtgtcg 360 gccctttact ccatcacctt cgactacccc gaggacgatg accagtgcct cgaggccctc 420 gaccgggtga aggaatacct cgccgactac gacatctacg tctccacctc gctgggcaac 480 acccagcagg agaccattga tgccgaggtg cgggtcatca tggtgtacgt tgccgtcatc 540 atcgtcatcg tcctgctcct gacgtcccag acctacgccg aggtacccgt cctcatcctc 600 accttcgtgg tgggcatgat cctgaacatg ggtaccaact tcatgctcgg caccatctcc 660 ttcgtgtcca actcggtcac gaacatcctg cagctggcgc tgtcgctgga ctacgccatc 720 atcttctgca accacttcaa ggaagaacac cagaccatgc ctctgaagga ggccgtcatc 780 gagtccctga gcaagagcat ccccgagatc agctccagct ccctgaccac catcggcggc 840 ctcgtggcca tgctgttcat gcagttccgc atcggctccg atatggccat ctgcctcatc 900 aagtccatcc tctttgcgat gctctcggtg ttcgtggtca tgcccggcct gctgatgctc 960 ttcggaccct acatggataa gaccaagcac aggaacttcg tgccggagat ccccttcgtg 1020 ggccgttttg catggcgcac ccgcaaggtc atccctgtta tcttcctggt ggtcatcctc 1080 atcggtcacc acttctcgaa cctttgtccc tacgcctacg gctacgatgt catcaaggtg 1140 ccgaagatga acgaatccct catcgcggac cagatgatcg aagaaaactt caccaagtcg 1200 aacctcgtgg cactcgtcta ccccaagaac gacgattaca gcatcgagaa aaagatgttg 1260 gaggagctgg aaagctgcga tgagatagac tccaccaagg gtctgtccaa catcgaggcc 1320 caggacggct atatgctgga agacaagctc accgcccgcc agttctccga gatggccgac 1380 ctggactacg aggccgccca gatgatctac accgcctacg ccatcgagaa cgaggagtac 1440 ggccaggtca tcggcaactt cgcctcctat aaagtgccgc tcgtggatat gttcctctac 1500 gtctgcgacg aggccgacac cggcatcgtc tccctctctc aggaagacct ggacgacctc 1560 cacgacgccc gcgaccagat ggagagcgca ctggcccagc tgcagggcaa cgactacaac 1620 cgcgtcctca tctacctgag cccctctctg gaacccggcc agactactta tgagttcacc 1680 gacaccatcc gctccatcgc ccggaagtat tacccggacg gcgagctgta catggccggt 1740 gacgccacca acgagtacga tttccagaag tccttcgccg tcgataatgt cgtcgtcaac 1800 gtcgtgtcca tcttcatcgt cctgctggtg ctgctgttca ccttccagtc cgtcggtatg 1860 cccatcctgc tcatcgtggt cattcagggc gctatctgga taaacttctc gttcccgtat 1920 ttcatgggga ccaacctcta cttcatgggc tacctcatcg tcagctccat ccagatgggc 1980 gcgaacatcg actacgcgat cgtcatcgcc acccgtttca acgagctgaa ggataagatg 2040 gagcacaagc aggccatgat agagaccatc aacttcgcgt tcccgaccat cctgacttcc 2100 ggcaccatca tgaccgtgtc cggcatcctc atcggccaga tgacttccga cgcctgcatc 2160 gtgggcatcg gccagtgtct gggccgaggc accatcatct ccatcatcct cgtcctcttc 2220 gtcctgcctc agatcctgct catcggcacc cgcatcgtgg accgtacctc ctttgccgtg 2280 ccgaagctgg tggcccgcag cagcggcaat ggccgtatgc gcgtcaacgg catcgtgcag 2340 ggcgagatcc acggctctgt ggccggtacg atgaacgcca tcgtggacgg cgacgtccag 2400 ctgaccgtca tctcgggcaa cgtctctcag gaactggacg acaataaaca acaggaggtg 2460 cagaatgaag accagtaa 2478 <210> 301 <211> 225 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(225) <223> BLCPAMOF_01925 <400> 301 atgaatggat ctcaacagat ctgctttaca gacagcgccg gaaaagcgct gttttctatt 60 cctgacaatg gtttactttg cctgttctat ggaaacgggg acaggcattt tgctgtttgc 120 catcgtctgg atgacaccca tgcagaaatt gacggggtaa attattcgat gccggacttt 180 gccaaaagga tgaaacacaa ccagatcggc tttgccccgg catag 225 <210> 302 <211> 528 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(528) <223> BLCPAMOF_01291 <400> 302 atggcagata aggcgatccc ggatatttcc cttggcggtg ctgaacaaaa catgagccgg 60 gaggagctgg cggcggtggc gaaagccatt gccgccctct cccaggagga ccgggacctt 120 ctgggcgctg ttcaggagtc tccctgccgg ctgactacga cggagcagtt tttggaattt 180 gagaaaaatg cggactgctt tgtgctggag ccccatgtcc agacgatgga ggctctgggg 240 tgggagtacc tgaaggagaa actgaccatc gacctgacgg acgacctccg ggccgccatt 300 gaccccgctc ccttcggccg gcacgcattg gaggaggact gcggctgttt caccagccgg 360 gggtatctgt atccctccgg tgacgagtgg cagcatgacc gcccccagga gaagccggcg 420 gaccggaaac cctctatcaa ggagcggctg gagcagagca agcaggagtg catgggaaaa 480 aacaaggcgc cggcgcccca caaggggaag tccgagccgg aactgtaa 528 <210> 303 <211> 357 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(357) <223> BLCPAMOF_02549 <400> 303 atgggggttt caatcgattt gagcggcctc aaggtaagag gaaatgcacg ggtaatgaac 60 gacgtcaaga taaccggata tgaggatgcg aagatacggg cagaaaacac tgagatagac 120 ggcaatgtgg agtttttgga gcggctggag atagggccgg ttcttgatga ggtacaaagg 180 caactccgaa atctggaccc ctcttcggcg gagtatcgct cactgaaaca aatcgtagaa 240 atgaagaata ctgctccgca gagtattatg aatgcgctga aaaagcatct tgccgatttt 300 tcgcagggcg tgctcagtaa tgttgtggca gcgtatattt ctaagcgttt cccttaa 357 <210> 304 <211> 162 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(162) <223> BLCPAMOF_00620 <400> 304 atgtcagggt ttgatgggat tttatgcctg taccatccgg gcaattcttt cccgaacttc 60 cgcttctggt acaacgcttg tgatgccgcc atgcttttgc gtagaaaggc ttgcggcaca 120 gcaggcaaat gttgtgatag cagtcagttc cttttttgtt aa 162 <210> 305 <211> 489 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(489) <223> BLCPAMOF_01298 <400> 305 atgaaacgta tcgcttctct tgcactcagc gcggcacttc tggcctcgct ttcgacaccg 60 gtgctggccg cgtcggccat ctctgtggat gcggccccta cggcagctgt gctggaagag 120 gaaaactctt tgtgggagct tccgcaggca gacacgccgg acatgagcaa cacggtctgg 180 tcgtttgccg gcggctacat cgacggcagc gagatgaccc aggccgagat ggacgagtct 240 ctggaagcat acggcggcac gctgcagttc acctttgacg ccgcaggcgg cgcaaagatg 300 atccagggcg gcggcacgct gaacggcact taccagtatc tcgacgacgg cagcgtgggc 360 gtcatcttcg actacaacgg cgaggagctg cgctacgcct gcatctttac ctggacggac 420 gaggacgagc tgctcatggt agccatctcg gatgcagagg gtgccgacgg cgtttacttt 480 gtccagtaa 489 <210> 306 <211> 1977 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1977) <223> BLCPAMOF_02542 <400> 306 atgagcaacg aaaaagaaac caaggtatcg gctctcgacg ccaaggccaa ggctctggca 60 aacgaagagg acgaagatac caaaatcgcc aagctgctga agaatatgcc gaaatggcgc 120 ttctattcgc tggcagttct taccgttatc tggacggtgt tccagctcta catcaagctg 180 gtcaagcccc ttgacccgtg gttccagctg ccgctccata tgtgccttgc actggtcgtg 240 gtgtggctgt acaatccgat ggtcgagaaa tccaagagcc acaataagct gtggtggatc 300 tacgacatct tcctcatcgc gtccagctgt tttatctgct ggttcttcct gagccacgca 360 gaacagctca actaccgcat cttcaatgtt gacgttatga ccaccaccga ggtcatcgtg 420 gcggtgcttc tggtcatcaa tgtcatggag gccgtccgcc gcgtggtcag tatgtccctg 480 ttctgggtca tctgcttctt ccttgcttat gcatggttcg gccagtatat ccccggcctg 540 ttccgcttct ccggcatcag cttccccaaa ctgatggaag tcctgatgta cggcgagaat 600 ggcatcttcg gctctccgct ggtcacttct ctgggcaccc tgttctactt cctcgttttc 660 ggcaccttct tctccaactg cggcggcggc ggtgtcctga tcgacggcgg catgaagctc 720 agcgataaga cggtcggcgg ccccgcaaag gcagctgtca tctcttccgg cctgctgggc 780 atggtttccg gttctgcgat cgcaaatgtt tccaccaccg gcgttctgac catccctctg 840 atgaaaaaga ccggttatga ccccgaagag gcggcagcag tcgagtctgt tgcttccacc 900 ggcggccaga tcatgccccc catcatgggc gctggcgcat tcatcatggc cgagatcatc 960 ggtgtgcagt atgcgcagat cgcagcagca gccgtcctgc ccgctgtggc ctacttcctc 1020 gccgtgttca tccttgtcca catgatcgca aagaagaagg gtctgggcaa agactccggc 1080 gtacattacg aaggcaagcc catcctgccc cgcgtgtacc gtctgctgcc catcatcgtt 1140 ctggtcgtca tgatcatcat gggctactct ctgccccgtt ccgcgatcta ctgcaccatc 1200 ttctccatca tcatcgcagc gatctctcct gagacccgca tgagtccccg caagctgctc 1260 cagaccctga tggacggcgt ccgtcaggcc gcaaacattg cgatccccac cgctgcctgc 1320 ggcatcatga tcggcatcgt ggtcaactcc ggcgttgccg tcaagatcgc aaagctcatc 1380 ggtacctctg gtgagggcag tctgttcatc gcactgctca tcgccgctct gggctgcctg 1440 ctgctgggca tggcactgcc taccgtggcc gcttacctga tcgctgtcac tctgttcgcg 1500 tcggctatcc agggtctggg catctccgct ctggtcacca atatgttcat cttctacttc 1560 ggtgtcgtgg ctcagatcac tcctcccgtc tgtctggcat cctttactgc agcaggcatc 1620 gcgggtgcaa gcgcatggaa gaccggctgg aaggcattct ccttcgccat caccgctttc 1680 atcgtcccct ttgcattcgt gtatcgtccc gctatcctgc tggaaggcac tatggtggag 1740 atcatcattg catactgcat cgtcattgca gccacctatc tgctggcctg cggcatcgct 1800 ggctacctgt tccgtcccct gaagatgtgg gagcgcatcg cctgctatgt cgtggccttc 1860 atcttcatcc tgcccagctc catgtctgat attatcggca ttgctggatg cgcactcatc 1920 atggcttact gcttcatgac gggcaagaag aacgccaata aggcacagcc tgcctga 1977 <210> 307 <211> 1095 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1095) <223> BLCPAMOF_02543 <400> 307 atgaaaaaga tttctcgtcg cagctttctg aaggtttctg gtactatggc agcggctggt 60 gctctggcag cctgcggcgg ctcttcctcc accagcaccg cagcttccag tgaggcagct 120 ccttccgttg aggcaaaggc tgtggatggt ctgcccgata tgagcaaaga gactctgaac 180 ttcagctccg ataaggtcgg ttctggctct tacaatatga tcgttgcaat gtccaaggtg 240 ctggagaagg ctggcggttt ccagactgtc aacgtcaacc ctgactctcc gggcggtatg 300 ggtgctcctt atctgtttgc ttccggcaac accgatctgg ccttcatcaa cggcgctcct 360 gcaaagtggg caatggagga aggcactctg ggcaagcctg ctaccagcgg ctatgcagcg 420 gtcatcggcg gcctgactgc tgtctgctac atcaactgcg tgtccaacgc attcctgcag 480 aagtacaatg tctccaccat cgaggagatc ttcgagcaga agctgcccct gcgcatcggc 540 tgctccgcaa agggctccat ggatgctgag ggcgcttacc tgctgctcga gtacttcggc 600 gtgaccgagg acgacctgaa gagctggggc ggctccatca ccaaccaggg cggcgatgcc 660 aacgcagacg ccatctcgga cggccagatc gacttctaca tcgaccacac ctcttctgct 720 tcttccacca tggctcagat cgctaccagc gtggatgtca ccttcctgca gtggggcgat 780 gacctgtgca gctggttcgt cagcgaaaag ggcttcgacc tcatcaccat cccggccaac 840 tccttcaagg gtcaggataa ggagctgacg ctgcccggca ctcccgactg cgtcttctgc 900 aaagagagcc tgagcgagga cgtcgtctac gccatcacca agagcctgag cgagaaccgc 960 gacgctctgg tggccgagta caattccctg tctccgtggg agcctgagac cgcttgggaa 1020 gagatgaagc gcggcggctg cccgctgcat cccggtgctg agaagtacta caaggaagca 1080 ggctacatga agtaa 1095 <210> 308 <211> 135 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(135) <223> BLCPAMOF_01191 <400> 308 atgttcacga ttcgcgtgga taagtccatc gtggattttt atgatgacct ggcacggcgg 60 acgaaccgct cccgaaacga gctcatcggg cttgcgctgg atttcgcaaa agataaaatc 120 attgtcgagt cttga 135 <210> 309 <211> 903 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(903) <223> BLCPAMOF_00744 <400> 309 atgaaaaaga tctcgcgtcg tgattttctg aaagtcactg gtttggtggg cgctgctgct 60 gccctgaccg cctgcggcgg ctctgcaagc tccgccgcag cctctacggc atcttctgcc 120 gccggcagca cggccgcttc cactgcagca ctgggcgctg acactcaggc catcgtggac 180 tgcggtgtcc tgaaagtggg cgtcaagaac gcagttaagg gcttcagctt ccaggatacc 240 ctcaccggcg agtacaaggg cctcgaggac agcctcgcag agatgatcgc agagcacctc 300 ggcgtggacg ttgagttcac cacagttacc gccgccaccc gcggcgagct gctggactcc 360 ggcgacatcg acgccgttct ggctaccttc accatcaccg aagagcgcaa gaagacctgg 420 gacttctcca ccccctacta taccgactac gtttccgttc tggtggagga ctccaccggc 480 atcaagggtc tggctgacct gaaggacaag gtcgtgggcg tctcctccgg ctccacctcc 540 gctcgtgctc tggtcaaggc catgatcgac gagggcgtgc tggacggcgc aaacttcgac 600 gccgacacct tcaacgccga cacttggaag gatggcatct ccttccgtca gtacgacgac 660 tatcccgcca tcagcaccgc actgagcgca ggcgaagtgc agggcttctg cgtcgataag 720 tccatcctcg ccatctacaa gaccgagggc cgcagctaca ttgacgctga gttcagcccg 780 caggagtatg gcgtcgccac caagaagggc agcgacttct ccaccctgtg cgacgacctc 840 gtcaagggct ggctggcaga tggcaccatc gagcagctca tcaaagacaa cggtctggat 900 taa 903 <210> 310 <211> 603 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(603) <223> BLCPAMOF_00109 <400> 310 atgcttcata gcatttcccg ccgattgacc gaatggtttt tccggcacaa ttgggtcgaa 60 gaaaacaatt acacctggtg tctttatgta gttgaaaaaa aacttcttca attctgtttt 120 cttctgatcc tgtcgatttg ttgcattatt tccaatcaat atttcaacac gcttgttttt 180 atggcaacaa tgtatttttt gcgtcggcga atgggtggat ggcatgctcc ttataattgg 240 atgtgtattc tgctgacaac agtaacaacc ttcattgttc tttatatatt cgcccctgtt 300 ctgatgcgca taaattcgct caccatgtgg acacttgata ttctattgat tctagctgca 360 tttagaacca accctattta tccgccgcaa ctacactttg aacaagaaat catatcttca 420 aaccggaaaa aaaagaattt cacacttgtc tgtattacaa tcatacaagt catttctgtc 480 cagcttgggt tccctcaggt actgattttt agttttaatg gcatactagt cagtatactg 540 cttatagtgg ccgagaaaat taaacagaag catggaggtt ttttgtatga agctgttgaa 600 taa 603 <210> 311 <211> 759 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(759) <223> BLCPAMOF_00104 <400> 311 atgcctgtat cgcgattctt gattcccttg gtttctactg tttggatctt tagtgtgatg 60 ggggggatgg gaatgcatgt attggcagag caacccacag aagtacaggc ggtaaggcga 120 cagttttcaa cattggagga agtgaccgct gtccaagtcc aggaggaggg gtcgacggtc 180 cgcttcctac cgggggaggg agaggaagtc tgcgtccgct atgcggatac gacagcggaa 240 gcactgtacg agattcaggt cgagaacggc accctggtcg tccaaaaatt aaaagcccca 300 cccccgaaag ttgtcaccat caacggaacg attatgcagt ttgaggtgga cagcgcctat 360 gacctggaga ttgtcctgcc ccagcgtcag tataagtcga tcgttgtaga aaatccgtcc 420 ggaggcaatg tagagatgga ttctattaca gccaaggaaa tctgcactga gttaaaaaat 480 ggatcttcgg tgttttcaaa aacacagtct gacagaataa aatcagaaat tgaaaacggc 540 tccgtagtgt tcgaacatcc aacttcctct caatacgatt gcacggtgaa gaacggagag 600 atcaagggag atgttgtagg caggtatgag gattacacgg taaaggctag ggtcaaaaat 660 ggttcttgta tgttgaaatc tcgcttggat gctgcgaatc aacacgcaat gaatctctac 720 gtggagaatg gtcgaatcga agtccatttt aaaaattaa 759 <210> 312 <211> 777 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(777) <223> BLCPAMOF_01437 <400> 312 atggttgatg ttgaaaaatg tccttatatt gaatataaaa ttcaaggaat aagtgggatc 60 gttgcaaaag aagaaaaagc cttttgcgta aaagatgatt taataataca aatcgaatta 120 aagcaagaag gactggaaat cactgggctg aaagtactat taaaagaaga tattgtaatc 180 gacgaacaag taaagcaggc aatcagacgg aaaattgagc attttttggt gaacttatat 240 ggaaatccga atgtctatgt gtctaaattt tctatgggaa tattgcagat cttcaatcca 300 aatagcaaga aaactcaata tgagttcagt agtacactgg tgatttctgc cgaatgttcg 360 tgtgcaatac agtgcaatgc tgattatttt aagaaaatgt atgaaaaaca agtgccagag 420 gataaagcgg atgaagttta tcctttgctt tttagtacga tgcgtattga tgatattttt 480 gttcgatatt tgatgcaata tgaaatcctt ttagggcaag taacgaaaga acacacgcag 540 aaggaagtcg ctaattacat aaagaaagtg tataatccgg ccaataaaga tagacagata 600 ggctttcaac caacgagaag gcaaggaaga aagtataaag aagatgatct gacctataat 660 agaaatctac tgggacatgg tgatatagaa aaagtcgttt cagaggagaa aataagacaa 720 ttaagcagaa gtataatgga tgtactctgg ttttcactat ggaataaggc cgaatga 777 <210> 313 <211> 243 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(243) <223> BLCPAMOF_00106 <400> 313 atgaaaatct atgattttaa tggcaagaaa aatattagcg gagaacgcat tcgagaagct 60 cgaatcaaga tgcatctatc acagaaagcg ttggctgtac ggttaaagct ggaaggagtg 120 gaattagaaa gagactgtat cagtagaatt gagatcggca ctcgctttgt tgctgattat 180 gagataaaga tgatagcaaa gacgttgaat gtttccgttt tgtggctctt agggatcgag 240 tga 243 <210> 314 <211> 177 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(177) <223> BLCPAMOF_00103 <400> 314 atgaacattt taattcctcc cattgttaac atgccgagag tatgcgatga atgtcctgag 60 gatttgtgtc tcattggata cacaccgcct tgcccgagtc agtgttacga ttttgatttt 120 acgtgcgagc cgatttacaa ttcgtatgag tgttcaggca catttaccat gagctga 177 <210> 315 <211> 600 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(600) <223> BLCPAMOF_00344 <400> 315 atgatgcagt atgtcagacg atgcagtttt atttgtggag ctgttctcag tctcctgctt 60 ctgctctgca gctgtcagat cggggtagga acaggacagt ttgtccagcc gccagacatt 120 tccccggacg acagctctca gggaaagacg cagcttcttt ctgctctgaa tcaggagtat 180 ttccaccgcg tccagatctc caaccatttt atacagggca gtgactctgc tgctgagaca 240 gtatttctgt atcttgagca gaactccggt ggcgacatca acaaagcggt cgagttgtta 300 gccgaaaatc ccgaagatga atattgccgc gcgaattgtg ccgacgctgt tctgagcaga 360 atttctccct cgtccagcga aacttactgg gtcagttatt ccttcctctc tgccgacatt 420 ctggaggacg gcgtcctgaa agaagatgca gagtttggcc ccgttgccgg aaagctcatc 480 gaccatcgga atcttctggt ttcgtcggat tcttatcagc cttacgactg ccagagatcc 540 ggctttgccg tcggcgtcat cggcggtcag gcgctcgtcg tggcagtgtt cgtttcctga 600 <210> 316 <211> 903 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(903) <223> BLCPAMOF_01922 <400> 316 ttgaatcagg aaccactacc gcagattcat ttgatccgtg atacagactt atccatcttt 60 gcgtatgagc tccatatttt tgccggagat tttcttaggg aatgcgaatt taatatgcgt 120 tctctggcga caaataccgg ggctgattcc attgccatca tggagaaaaa tcacatgtgg 180 ctttccgacg ctttgtttgc ttattgttct acggcggatc ttcatcaaat gatctcaaca 240 acggagttta tcggagcgag ggttttcctg tttcatacgg atcgcagaga gggcggtcac 300 ttgtacggag atgtcctgat gatggattta gacacgctgc ggcaggatat aaaaagaaat 360 atcctctatc cctgcggcgt caatgtcgaa cgcaaagatg gttcagcggc tacggtcagc 420 ctgaaagaat ggactgaaat ggagctttac gaaaaagatg ctctgaaaag ttggggattt 480 tcttatgccc cgaatcaagt tacggaatgg cagtaccact attccacgat gttcagacag 540 tggatggatc aggcatttcg ttatatgccc caggatttag aagaacgcct gaatatgcaa 600 tatatggagg cagcccagaa cccggatatg gataagtacc gcataccaca gggaacggca 660 aaacagatgc ttctttatga cgaagcccct gtgtatcgcc ttcttccatc cggttcggag 720 aaaattgcgc ccattgcggc agtctctacg ggcctgtggt atgaaaatta ccgggagttt 780 gccattgcac cggaggattt aggcgctctg gacaaactga tccgcaggga aactgaccgg 840 ctcacaggaa acctcccaca acttctcaaa aacgaagaac gccgccctgc cccggagcga 900 taa 903 <210> 317 <211> 390 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(390) <223> BLCPAMOF_02043 <400> 317 atgaacttta gcgaagcaat gcaaatgctt ggaaccaagt tgcaaggaaa gtacgggcat 60 ttaggattca agtataaaaa atccgacaaa acacttacga ggcacagtaa aaatttcacc 120 tatatgattg cgttttcctc attcggcggg aacacaaagg atagcataag catagaggtt 180 tgctatataa tcaacacccg tccatacgac ccttatggtt atgccaaacc agacgccaac 240 acacaaccac tgttttacag tttgagagac aatgaaatat atcttgatat aggaaatgaa 300 gaaaaaattg acattgcctt tgaggttgtt tgtcaatgga tggataaaat actgattcca 360 aaaatgaatg agctttgtgc taccgagtaa 390 <210> 318 <211> 750 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(750) <223> BLCPAMOF_02042 <400> 318 atgaacacag aatcattgac agcaaagctc ctggacctgg tcgaaggccg ggaaacacca 60 gaaagttggc ggaactggtg ggacgagcat gagccggaac tggaaaccct gctgagtcgg 120 ggcgaatttc tgaagctaaa gccctgccgg catggtttcc agtgggtccc ggtgtttggc 180 agccaaaagg gagccatcgc cattctggaa aagagcggca cagcatttga ggccagcaat 240 ctctaccagg agcggtatct ggcggagctg gatgcgttct gcaaggagca gaagcgagtg 300 cagcgggaaa agcaaaagga attcaaggcc agccacccag aactatttgg ccgatacccc 360 aagttctcca aggcgttggc aaaggtgctg gacccctctg atgagatcaa gcccgccacc 420 acggaggagc aaatcgggaa tcaagaaagc gtgatggact tcacgctccc ggcccaggtg 480 cgggagtttt tcctgctgac cgcaggcatc aatgtattca caggcgtaat cgttgaactc 540 tctggaacat ttaatttgac catccacgga gagcggtatt gcgtgctggg cgagttctgg 600 aaagaagcgg acggcgacca gctcctgctc cgccccggag aggaaaccat ctggtactac 660 gcccatgagc aggacaaggt caatcgcctc tgcaatgata tgacagaact gctggaaaag 720 aaattagcga ggtatctcaa tgaacactga 750 <210> 319 <211> 480 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(480) <223> BLCPAMOF_02044 <400> 319 atgaacaaat caaatcaaca tagcttgccc cagtcgttag aagtggccat cgcactatgg 60 gagcaacacc tgaatgaatt tgccgttctc ctctcggatg ccatcccttc cttaaagaac 120 acagactgga ttatagagaa aaagcgagtg tttgtttgtg gctcagatgg ttccaagaaa 180 agaaggcgaa ccgcaagcgg gccctcttac cattctggcg tttcgctgaa ccgctctgat 240 acagaacaga tctggaatca ctttcaggcg tttgcgggag ccattggcct ggatgaggtg 300 gagcggattc ctgccaatga gcaggaactg ggacggtatg atttccgagc gtccaacagc 360 cagacagcgg atagtttcac ttgcctgatc tatctgccgg gcgagtggaa tcaggctggg 420 gtccatatct ctgtatttat cgggccgaga taccgggatg cggatttgca tgagacataa 480 <210> 320 <211> 309 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(309) <223> BLCPAMOF_02049 <400> 320 atggcatggc gaaaagtaat agaagcctgc atggaggatg tgaaacacca cttcgatgac 60 atccagcagg ccattgagtt tggctgctac atccagccgg acaactactt tgtgtcctac 120 atctttgcca cggactcgca attagagacg gcgcggcaga gcggcctgac ggaacagatc 180 aattcctatc acagagagca gctgataaag agtcattacc ccattgaggg aatcaaggac 240 tgcacctttg cctcacagga ggaatgtgac cgggaatttg gcgggaattg gtattactat 300 ttcaaatga 309 <210> 321 <211> 1176 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1176) <223> BLCPAMOF_02536 <400> 321 atggcaacca agaaactgaa cggaaccgtt atcgtcacct accgctgcaa cgcgcgctgc 60 accatgtgca accgctataa ggcaccctcg aagcccgagg aagagatcag cctcgagacc 120 atccgcaagc tgccgcccat gtattttacc aacatcaccg gcggcgagcc ctttatccgc 180 acggatctga aggacatcgt gcgggagctg cggaagaagt cggaccgcat cgtcatctcc 240 accaacggct tcttcaccga ccgtatcctc gatctgtgca aagagttccc cgacatcggc 300 atccgcatct ccatcgaggg cctcgagcag accaacaacg agatacgcgg cctcgccgac 360 ggttacaacc gcggctacac caccctgaaa aaactccggg agatgggcat gaaggatgtg 420 ggattcggca tgaccgtgca ggacaagaac gcccccgacc tcgtccccct ctaccgcctg 480 tcggatgaga tggggatgga attcgccacc gccaccctgc acaacagctt ctacttcgtg 540 gaggccaaga acatcatcca cgaccgcccc atggtggcga agaacttcga ggccctcatc 600 aacgagctgc tgcggagcaa ttcgcccaaa aagtggttcc gcgcctactt caaccacggc 660 ctcatcaact acctctacgg ccagaagcgt ctgctgccct gtgatatgag cttcgatacc 720 ttcttcatcg acccctacgg cgacgtcatg ccctgcaacg gcaccaagga taaggaagtt 780 atgggcaacc tgaacaccca gagctgggac gagctgtgga gcagccctga ggcagaggcc 840 gtccgcgcca aggtgcgcca ctgcgaccgc gactgctgga tgatcggctc cgtctcgccg 900 gccatgcaca aatatatctg gaagccgggc ttctgggtac tgacccataa gttcaaggcg 960 ctgttcacca agactcctta cagtatgtat gagctgaaag tctgccgcga ctaccgggac 1020 ggtaaggtgt cgaaggaaga gctggaccgc tgctccacct gcgacctcaa ctgcgtggtc 1080 aataacggcc tgagtgccgc gtcgcaggag cagctgcgcc ataagtccgg cgaggagatc 1140 gtggacgccg atattgccga ccagctcaga cagtga 1176 <210> 322 <211> 798 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(798) <223> BLCPAMOF_01185 <400> 322 atgctgacca attaccacac ccacaccacc cgctgcggcc acgccgaagg caccgaggag 60 gaatacatcc tcacggccct gcgctgcggc ttcaaggtgc tggggttttc tgaccacacc 120 ccctgggcct acgcgacgcc gggcttcgtc agccgcatcc ggatgctgcc ctcccagctg 180 gacgattacg tcctgaccct gcgcaggctg cgggagaaat atgccgacaa actccacatc 240 cgcatcggcc tcgaggcaga gtatttcccg gcctatctgg gctggctcag agaagagacg 300 gagcggctgg acatcgaata tctcatcctc ggctgccact acgacaccac cgacgagcag 360 gacgccaggg ccagccgctt cggcggcagc ccctccaccg cccacggcag acggtatgcc 420 gaacaggtgg tggaagcgct ggaaacggga ctttaccggt atctggccca ccccgacctc 480 tttttgaacc gggtgacggc cttcgacgcc gacgccgaga aagcctgccg ggacatctgt 540 gccgcagcgg cgcggctgga catccccctc gagtacaaca tggccggact gaccctgcag 600 ggccgtcccg acggctctct gggctacacc cgggacgagt tctggcacat cgcggcggag 660 taccccgtca aggccatcgt gggctgcgac gcccacgccc cctcggagtt ggacgtcgtc 720 cccgccatcg aggaaaagaa ggccttcctg cacagcttgg gcatcccggt gctggacacc 780 ctgccggggc tggaataa 798 <210> 323 <211> 489 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(489) <223> BLCPAMOF_02550 <400> 323 atgaagttca aagaaagcga aaaatgtatc acagtggatt cgttgaacat cacacgcaat 60 atcatgatgt gggatgagac gatgatacag ctcagcaatg tttcagctat cacgaccaga 120 ccgctgaatc cgatctatgt tccgtggtat cctgctgctg cagtccttct tcttctggga 180 ttgtcgggca tccagtctta tagcggtaag acgatgggat ttctcatgat catagcgggt 240 gcggtgatgg cattctggtg cttcaatatg aactcagagc ggaaggagca gactatcctg 300 acagtccaga tgaactcggg agtgagttac ttctttatgg taaaagaaaa gaagatactg 360 aataagctgc tggcagtgct ggcgaagatc atcgcagatg gcggtgtggg taacgcaagc 420 atttcaatca gtatcaaaga ctgcacgata cgagataatg cacggctttt caacggtgtg 480 aatatctga 489 <210> 324 <211> 453 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(453) <223> BLCPAMOF_00290 <400> 324 atgtgctgtc ccttccacgg ggataaacac cccagcatga aggtggacag ccgtttccac 60 tgtttcgcct gtcaggcaga tggcgatgtg atcgattttg tcggcagact ttttcaactt 120 tctccctata aggctgttga aaagttgaag gaggacttcg gcatggcact tgccgacggc 180 aaggtgcggc ttgctccccg cagaccgccc accgtccggc agcagctgct ggactattac 240 cgctgtctgc agcgttggcg ggtccgatac gcaccgcagt cacccacaga agaacttcac 300 ccctgcttcc ttgaagcgat aaagaacctt gacatcgttg aatattatct ggactgttcg 360 gtgctcccgg acccgcagac cgaaaacgag ctacggaagt attgggaggg attgcatgag 420 cgactggaaa aagaggaacg aagattggcg tga 453 <210> 325 <211> 108 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(108) <223> BLCPAMOF_00291 <400> 325 atgaacaaca ctctgacgga tcgatgtgtg aataaaccca acctcaccca cgcccctcac 60 cgggcttcgt cctttcgcct gtaccccacc cattgggacg gagggtag 108 <210> 326 <211> 354 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(354) <223> BLCPAMOF_00695 <400> 326 atgacagtta aggaatgtta cagccagatg ggcggagact ataacaatgt cctgagccgt 60 ttttacgatg aggcaatgat aaagcgcctg ctgggcaggt ttatcgacca caccagcttt 120 cgtgcgctgg aacaggcgat gaccgagggt gacacgcagg cggcgttcaa tgcggcgcat 180 accctccggg gcgtttgtca gagcctgtcg tttactcagc tgtgcggcac gctggattcc 240 atcaccgagg cgctgcgggg cggcaatatc gctgttgccg cagccgacat ggacaaggcg 300 aagcgggagt atgacgtgac gctcagtgcc atccgtgcct gcatggaaaa ctga 354 <210> 327 <211> 192 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(192) <223> BLCPAMOF_00111 <400> 327 atgcagaacg attttcgatc cgagctgtac atttctacct gtccccgatg cggcacccgc 60 ctcatgtgtg gaaagatcat cgtcaccggt ttgcaaaaat gttccaagtg caaccggcac 120 tgggtcatcc agatggaaaa gaacaaaata tccgtcacaa gggcatccct ctattttgag 180 gagtttgcct ga 192 <210> 328 <211> 168 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(168) <223> BLCPAMOF_00110 <400> 328 atgaagctgt tgaataacat cggaaaggaa atcctgaacc gcgccattgt tctcgagcga 60 tttggctggc ctccttcttg catgggaggc gtatatcagc ccgagcgtcc cgtttgtaac 120 tatccccagc cggatcatga aactcctccc aaagaaccca acaagtaa 168 <210> 329 <211> 240 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(240) <223> BLCPAMOF_02828 <400> 329 atgacaaaat tacagatcag aatgcggcag gtcgatcagg tcaaggaatt tgtagatttg 60 ctgtccaaat atccctatga gatggactta gtctccgggc gatataccat tgatgccaaa 120 tccctgcttg gcatttacag tctcgacctg agcaatccgc ttacccttgt gatttattcc 180 gattcctgcg aagaactgct gacacagctc catgcgttgc tcccagattg catcgtctga 240 <210> 330 <211> 183 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(183) <223> BLCPAMOF_01684 <400> 330 atgctcctgt ttgcccagat acagctccac gatcatccgt ccgttttcgg tattgcaaag 60 ctcttcattg caataaccgc agagctttcc gtccgcctgt gccacatata cttactgctc 120 tttccgtggg agacttttca actgcacctg ctgcacaaag gacgaagccc agcggctgtg 180 tga 183 <210> 331 <211> 354 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(354) <223> BLCPAMOF_00911 <400> 331 atgaacgact atatcaacac taccgcaacc actgtactta ctgccgcaca gctctttcgt 60 atcataaaga gctttccccg tgtatggttt tcgctcatca gctctaatcc ttgcgtacgc 120 tatgagtttt tcgtcccgtc cgaagaggtg tttcttgatt ttgaaaatgg tgtaccaaca 180 atttgtgcag gattagatat tgaaaaagac tcctctgcct ccatctcctg cgacacatat 240 caatgccaag ttgattttga ggataatgac atcataagtc ttaacgccaa accacttaca 300 aatggtgata gcagctgtcc taatatcagc atctatgtca cgcagtggct ctaa 354 <210> 332 <211> 1314 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1314) <223> BLCPAMOF_00915 <400> 332 atgaaaaaga agtcaatatc ttttttatta tgcatcttca tgctattact ttttctcccc 60 acagtttttg ctgttgagcc gctgtctagc gaggaagttg ttgcccaaaa gcgtgcgtgg 120 tatccgttta ttaaaacttg tgaagaaaag ttaaacgaga aagctaaatc tgagtcgctt 180 caagatatta aaattgaccg tattattgtt gaatctgtca aatatcttac tactgaaaat 240 gaagtgaacg ctgccataaa tgaaaaaaaa ttcgttccaa acattactat ctatattcat 300 ttttctgcaa tacatatagt gaaggtttct aaatatattt atacctatat gcctcaaaat 360 gattatgaga atttatataa tgaaacctct tcaaatctaa cagtttctaa ttataatacg 420 aacaattcta ttctttcagg agatttcgac ccatcttttt gcacttttct aggtgatgaa 480 tacgtatata attctgcact atctgggcgc tattatattg cccttgatat tgctgactat 540 aagaaccata tctctactac tgtagaccct accgtatctg aaccctccac ctctgaggtg 600 aaatcatctt cgactgcttc ggggtttcta tcgaaagaga ctagtgactc ttccgcttct 660 ttgtctcttt ccacagaata caccaaaggt caagaaatta ttatttctgg caagacagat 720 ttcaactatt tctacactta cagagatggt ttaaagtata aatgcttttc tctgacaaaa 780 aatggagaac gggtttacgc ttctgtgcgc gaagaccttt atgactacta taagaatgca 840 ttccaaaatc attcgcttac tctaaaaggc acatatgaat ttaccgcaga agatggttct 900 cctgtcgttt cggtctccac acttgttgaa ggaacaaaag aaaccaattt gagaagttac 960 ctctggacag tgaataaggg ctctgttaag aatccaaatt ttaaagcata tgctgatctt 1020 aaaggtgacg gattggtcct ttcagcggct aaagatgggc agtctattac gattgattct 1080 aatccgtggg gcgctgctaa gggttcgcag gcatacaagc ttgataacga ttttgctctg 1140 ttgatgatta aagagttaaa ttctgagtta ggtctgcctg attggctcta taccgaaatg 1200 atgggtacac gcgctcttga tggtcgtcag aaagaagttt tcgattatgt aactgttatt 1260 tggtcctatc atccagatag cggaatcaat atcctctatc gcaaaaataa ctaa 1314 <210> 333 <211> 2154 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2154) <223> BLCPAMOF_00598 <400> 333 atgaaggaga ccgccccgaa aaagatacgc ttccagacgc tgcgcaccct gtgggtgccg 60 ctggccatcg gcgtcgtcac agtagccgca ctggctgtcg tggtgggtat ggtatggaag 120 gactaccgca ccgccatgat ggacagccag acccggcaga tggagctggt ggtgcagagc 180 accgccgaca gcatccgcgt cctgctggaa gaatacgccg accggctgga ctccatcgcc 240 ggaaaagcgg agggcagcaa agcgttccgc cccacggtgg cccggagcga taccatccgg 300 gacgtctggc tggaaaacag cagcggcgag gtcatctaca gctgctacgg cctcagcgcc 360 gtctgcgatg tcctcatcac ccggacggag gacatctcct actggcagta ccacagcggt 420 gacgagcact atcttgtgat gaagaagaag gccggggatg agacagcctg cctcgtggta 480 gactccacgg tcatgtatca gcagctcatc tcggagatcc atgtcggcag gaacggctac 540 atcatgataa agaatgatga taaccttgtg gtcatgcacc ccgaagccgt tcagtggggc 600 atcaaggtcg tggagggccg ccagcgcatc tatcagggga aggaactgga catgagcagt 660 ctgagtgagc tgctgcgcgc tcagcaggaa gaggaatccg gcacgctgga ctactactcc 720 tactggtggg ccgacccgga tctgccccgg gtgcataaga taagcgcctt tcgtcatctg 780 gacgtggggg gcagcttctg gatcgtcagc gctgtggtgg actacgacga tttctacgag 840 ccggtacagc agagcttcgt gaaggtgatc ctcatcttcg gcggcgtggc gctggtgctg 900 gtgctcttca tgtcccagat gttccggctg caggagcgcg accgccgcag cgcgaccgag 960 atcagcgatc tgaagactct gaaccagatc ctcgaagagc tccaccgcag cgaagagtcg 1020 ctggcccacg gccagcggct gcagatgatg gggaccctca ccggcggcat cgcccatgag 1080 ttcaataact tcctgacccc catcaccggc tatgccgacc tcatcatggc cgacgccgac 1140 ccgggcagcg agatctatga caacgcgatg gagatcagcg aggcggcgca gaaggcgcag 1200 gaggtcgtga aacaaatttc ctccatgagc cggaaaaacg tggagacggt ctacgacgcc 1260 gtgtcggtgg agggactgct ccatcgaacc cggaagctgg tggagacgaa ctgcccgaag 1320 aacgtggagc tgaaggaaga aaatgagctg agcggcgaat gcgttctggg aaacgcgacc 1380 cagctgcagc aggtgctgct gaacatcagc atcaacgcca tccacgccat cggcaccgag 1440 ggcggaaagc tgaccatccg gggcagtgtc gtgccgcgca gtgagctggc ggcgctcttc 1500 ccggaagaga agatctccga agagtggtca agctacgtct gcctgagcgt caccgacacc 1560 ggctgcggca tggacaagga gacgatgcag cacatcttcg agcctttctt caccacaaag 1620 aagaccggcg aaggcaccgg tctcggcctt gctctggcgg accagatcat ccgcacccac 1680 cggggccgta tccgggcgga gagcaccatc ggcagaggca cgaccttcta tgtctatctg 1740 ccggtgctgg aacagcagca ggagcgcgaa cagttgcagt ggggcgtgga cagcaagctg 1800 cgcatcctgg cggcggacga caataacaag gtcctcgacc tgctggacaa agacctcagc 1860 gcgctgggcc tgagcgtgtc cacctgctcc cgccggggcg agctgcgcca gctgctggag 1920 cagcagccct tcgacgtcct tgccatcgac gagagcctga tgagcggcag cggcgtggat 1980 ctctgcatgg ccatccgggg ccgctaccca ggcatgaccc gcatcgtgat gaccaatgcc 2040 cccacaaggg agatcgtgga tgcccgcagc cacggcgtca tcgacggcta tgtggtaaaa 2100 cctgtgtcgg cgtctacgct tctggcgcag ataaggagca gccggaaaga ataa 2154 <210> 334 <211> 693 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(693) <223> BLCPAMOF_00597 <400> 334 atgtcgtatc atgttcttat tgtagacgat gatccagcaa tttgcaaact tttatcgaaa 60 gttatgataa gcaatgagat ggaccctctc gtcgtcaaca gcggcgcggc ggcgctggac 120 ctcatcgcgc ggcagagcag cacgctggat atgatcctga tggacatcac gctgggcgac 180 atggagggct tcgatgtcat ccagaccatc cggcgcaacg gcgtcaccac gccggtcatc 240 atcatcagcg gccgcaacga ggactacgat ttcatgtacg gcctctcgct gggcgccgac 300 gactatgtca ccaagccctt ccgtccccag attttgggcg caaaggtcaa ggccctcatc 360 cgccgcagca agagcttctc gcaggagaac aaccagcaga tcagctgcgg gcctttcctc 420 tgcgacacca ccaccatgcg cttttataaa aacaatgtgg agctgaacct ctccgagaaa 480 gagcgcagcc tgctgctgct ctttgtgcgc cacccgcagc aggtgttcac caaggacatg 540 atatacgagc agatatgggg caatctcatc gctgtggacg acaacgccat catggtctac 600 atcaaccgcc tgcgcagcaa gatagaggac aacgcccgca cgccccagca catcatcacc 660 atccgcggcg tcggctatcg tttcgtgccg taa 693 <210> 335 <211> 1569 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1569) <223> BLCPAMOF_00596 <400> 335 atgttgaacg cagtcggcag agaaattccc gaagagatcc tcgagcgcac cggcaaagag 60 gtcttccagg gcaacaacta taaggacggc aaggccttcc agaaggccag cccgaaggtc 120 acccccgtga tgcgcaatga ccacgacaag atggtcaagg acatccacga ggctctggtc 180 atgtgcaatg cccacgacgg catgaccgtc tccttccacc accacttccg cgagggcgac 240 ctcgtggtct gcatggtcat ggaagagatc cacaagatgg gcttcaagaa catcaccctg 300 agcgcaagct ctctgggcaa ggctcatgac gccctcgtcc ccatgatcga ggacggcacc 360 atcgtcaaca tcgagtcttc cggcgtccgc ggcaagatcg gcgatgccat ttctcacggc 420 aagctgaagg gtctggctac catgcgcagc cacggcggcc gtgtccgcgc catcgagacc 480 ggtgagactc acgttgacat cgcctttatc ggcgcaccct cctgtgacga gtacggcaac 540 tgctccggta tgggcggcaa gaccaactgc ggtgtcctga gctatgctta cgtggacgct 600 gagatggctg actatgtcgt cgctgtcacc gattgcctcg tggactaccc caactacccc 660 gcagagatca accagaccaa ggtggattac gtctgcgtcg tggaccagat cggcatcccc 720 gagaagatcg ctaccggcgc tgcaaagccc actaccgacc agcgcaagat cctgatggcc 780 gagtactgca ctcaggtcgt tgcaaacacc ccgtacttca aggacggctt ctcttatcag 840 accggtgtcg gcggcgcatc catcgcctcc accatctctc tgtccaagat catggaagag 900 aagaacatcc acatgggtct gggtgtcggc ggtctgacca agcccatgtg tgagctgctg 960 gaccgcggtc tggcccgcaa gctggtggat acccaggact tcgacctgga cgctgtcaac 1020 aacgtcactt ccaaccccaa ccacttcccc atctctgctg gcgagtacgc aagcccgatg 1080 aacaagggcg ctttcgtcaa caagctggat tacgtcattc tggcctctct ggaagtggat 1140 acccacttca actgcaacgt cgtcgtcggc tccgatggca tcatcaccgg cgcacagggc 1200 ggccatcccg ataccgcaca gggtgcaaaa tgcaccatcg tcatcgctcc tctgctgcag 1260 ggccgcatcc cggccatctg caccgacgtg accaccgtca ccaccccggg cgagagcgtt 1320 gacatcgtcg tcaccgacta cggcgtggcc gtcaaccccc gccgtcccga cctgctggag 1380 gctctgaagg ccgctgactg cgtgcctctg aagaccatcg aggagctgcg cgacatcgcc 1440 tactccatcg tcggcgagcc ggagaaggtc cagttcggcg accgcatcgt gggcatcatc 1500 gaggcccgcg acggcactgt catggacgtc gtccgcgaag tcaagccttt ctctttccgc 1560 gaagattga 1569 <210> 336 <211> 903 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(903) <223> BLCPAMOF_00595 <400> 336 atgaataatc cgaacaagaa gcgcctgcgc cgcacgatga tgttcctgaa tgcgcagaag 60 cccggcctca tcaaagaccc ctacatctat aaggccgact ccctgatgct ggacctcgag 120 gacgctgtcg ccgagaacca gaaggatgtc gcccgcttca gcctgtatca tgctctgaag 180 actgtggact accgcggtgc agagcgcgtc gtccgtatca acggtctgga cactccctac 240 tggcgtgaag acatccgtgc ctgcgtggcc ggcggctgcg attccatccg catccccaag 300 accgagcacg ccgaggacgt ccgccgcgtg gctgccgcca tcgccgagga tgagaagact 360 tacggccgtc ctgagggcga agtcctcatc atcgccgctc tggagtctgc ccgcggcgtc 420 atgaacgctc tggagatctg cgagtctgac gagcgtctgt tcggcatcgc actgtccggc 480 ggcgactaca ccaaggatct gcagacccac attaccggca ccggcattga gctgatgggc 540 gcccgtcagc agatgatcat tgcagcccgc gcagcaggcg tgcagtgctt cgacaccgtc 600 tataccgacc tgaaggatat ggatggcttc cgcaaggacg tcgagaacat ccacctgatg 660 ggcttcgacg gcaaatccat catcaacccc cgtcagatcc ccatcgtgca tgagatcttt 720 acgcccaccc agaaggacat catcttcgct gagaaggtcg tcaaggagat cgacagcaag 780 aaggcactgg gcatcggcgt cttcaccgtt gacggcaaga tgatcgacat cgccttctac 840 gacggtgcaa agcgcaccat cgatctggcc aaggcatccg gcgtgtataa gggggatttg 900 taa 903 <210> 337 <211> 300 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(300) <223> BLCPAMOF_00594 <400> 337 atggagatca agaaagcagc cacggctggc actctggaat ccagcgactg catggtgacc 60 gtcgagccgg gtgagggtaa gatcgatttc tccctcgaaa gctctgtcat ccatcagtac 120 ggcaaccagc tgcgcaaggt cgcactggag accctgaaga atctggacat cgacaacgtc 180 cgcatcacca tcgtggacaa gggcgcactg gactgtaccc tgaaggcccg catcgagggc 240 gcggtgttcc gctctgttga ccagtatgag aatctgccct ggggaggtgc cattcgatga 300 <210> 338 <211> 258 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(258) <223> BLCPAMOF_01868 <400> 338 atggaaaaag aaacaatggg aactgtaatt tcagttataa aacaatggtg gttaaaagtg 60 aatcgtaaac ctgcccgcgt tcatgcgatg gatggcgcag cctttccgca tactatcaag 120 gtcaaatata cgatagacgg caaagattac atctgccgaa aatggattgg cgcaggaaac 180 aaagtccctg acaagggaac aacgattaaa gttatctatt gtgaagataa gccatcgaaa 240 gcaagaattg aactctaa 258 <210> 339 <211> 2262 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2262) <223> BLCPAMOF_00278 <400> 339 atgcagaaat taaagcagat tccaaagcgg gtgcaccatt ttctaattgg gctggtgctg 60 acggcggtgc ttggggtgct ggcctttgcg gtggtgaaca cctacaccgc ctatacggac 120 atggtggtgc agcaacagca gcagtacctg ctggtgacgg cccgcgccgt ctccaaaacg 180 ctctccctct atatctccgg gcagctgcgg gacattgaaa ttttgacccg ctcgccgggc 240 ttcctcaccg agtttgaaaa ttactacgag acgggcggtg acaccgccct gagggaacac 300 atcgtctcct atatgctcag ccaaaagcgg ggcgtcaagc gcatttacct gctggacaaa 360 aacggcgacg tgatgtacca gtacaacgat tatcctttcc tggaagtctt tgacgaaagc 420 ctgctgcacc tgaaagagtg tgccgccgcc cataccagcg gcattggctc ggtcttccgc 480 atctcgcccc agcactacgg cctaatgctg gtgaacgacg tcattcacgg cagcgagtcg 540 ttgggcaccg tggtgatcgt catcgacctc gaacaggtgt acgaggaata tcttgcgccc 600 ctgaacatcg agaacacggg agacatcatc gtcaaaaacg aaaaaggcac catcatcatg 660 caccccaacg cgaagctgct gacgttcaat ccgttccggc agatccagga gctggacact 720 ctgcctcagt acaagggtct gaacgagctg ctcacacggc agtacagcca ggaggagggc 780 acggccattt accgcgatta ctccaatggc atcgccccgc ccgaggatga gatcgcggca 840 ttttcccgca tgaacgtcaa caacacggcc tggtacgtct cggccgtgct gccctactcc 900 accgtcaaaa acctcatcga ccgcaatgtg ggccagtttg gtatgctggt ggccgccatc 960 ctttttgtgc tgggcgtgtg cgtcatcagc ttttacgcca tgcgcaaaaa ccagcagaat 1020 ttgaagctgg aagccgccta cctcaaggac atcaaccaca ccctgaaaga gctgcaccag 1080 agccgcgagc aggtgtacca ctaccagaaa cttcagacca tcggcgcgct ggcgagcggc 1140 atcgtgcatg agttcaacaa cctgctcacg cccattctgg gctactcgga gttcatccgg 1200 gagcggatgg ggcccgagag cgaatactac gatgacatga gcgagatcta cgaggcgggc 1260 acccgcgcga aagagatcgt ggagcagctg ctgcccttca gccgccgcga gacagactct 1320 accgcctacg gccccgtgaa tttggaagcc gttttgcagg atgacaccaa gatggtctcg 1380 atgatcctgc cctccaacat ccggctcgaa aaagggtata aggatatcca cgccaccgtc 1440 tacggcagcg ccacccagct gcatcaggtg ttgctcaacc tctgctccaa cgctgtgcag 1500 gccatggagg gcaagggcgg caccctgacc gtgcaggcgg agaagatctc cgccgacgcc 1560 ctgcctgcca actatcaccc cgccgtcgcc agcggctttg tgcgggtgcg ggtggcggat 1620 accggctgcg gcatgacctc cgagacgctg gcccacatct ttgatgcctt cttcaccact 1680 aaggcggcag gggagggcac cggcctcggc ctttcggtgg tgcagaacat ccttatcagc 1740 cacggcggct tcattgaggc ccacagcacg gtgggcgagg gcagcgagtt tctggtctac 1800 ctgcccgtca cagcgcaggc agtggctccc gaacgccctg ccgcgcctgg tgcgcccgtc 1860 cggctcaaca gtgggaaaca gcccatcctg ctggtagacg acgaggagcg ggtggcccgc 1920 tacctcaagc gccgcctgac tcgcagcggc tatacggtgg atgttttcac cgatgcggaa 1980 gaggccctcg acgccttttt ggcgtcgccc acccgctggc agctggccct tgtggatggc 2040 accatgccca agtataaggg tactgccctc atccagcgga tgcgcagcga gaacccgaac 2100 ctcgctgcca ttctgatgac cggctttgtg gagcaggatg ccgtgcagat gcagcaggag 2160 ggattgatcg acgagatttt cctgaagccg ctcgattacc gaaagctgac ggaaaagatc 2220 gggaaactac tggcgggtga gcctgattta accactgttt aa 2262 <210> 340 <211> 342 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(342) <223> BLCPAMOF_01901 <400> 340 ttgttttcaa aggagggatg ctatattacg caaaatgaag tcaatgccgt ttttgacgaa 60 caggtgcggc tctgtgctga taccttgaaa cggaaaacca aagaatacac cggggatgac 120 ccggaccggc tgggtgcatt taaggcagcg gcagctttac agcacacaac gccccagcgt 180 gcccttgccg gtatgctggc aaagcatatt gtttctctat acgatatgtg ctttgccgaa 240 gaagtggttt atccgatgga cacatgggac gaaaagatca cagacagtct taactatctg 300 ttcttactga aagcgattgt aaaggaggga cataccaatt aa 342 <210> 341 <211> 306 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(306) <223> BLCPAMOF_02241 <400> 341 atggaccata tcattctcgg catccttttt ctggtatggg gcgcggcgga catcctccgc 60 ctcgagctgc ccggcatact gggcaagcga ctgaaatcta ccagcgccga ggcccgccgc 120 ctctggcaga ggcttctggg tgtgctggag cttatcgtag gcggcgggca gctgctgttc 180 tactttttct ccgacaatca gaccgtcacc agcatcatcc tcgcggtgat gatactcgcc 240 gccgtctgca tcctcgggcc gtactaccac tggcggaagc aggaaaaaga gaacacacag 300 gaatga 306 <210> 342 <211> 573 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(573) <223> BLCPAMOF_00600 <400> 342 atgcgtgaga ccccagtctg caccgcggcc gatgccatct acaagctggc ggcgggcaat 60 ctgaaatacc tgaacgcgga aaacgggagc ggcgatattt cccgccgtat ccggatgtcc 120 acctggacga agggccagtc gccctacgcc atcatcgtca cctgttcgga ttcccgggtc 180 atcccggaga acatcttctc ggcgggcatc ggtgaactgt tcgtcatccg gctggcgggc 240 aacatcatcg acgaccacca gctgggcagc atcgagtacg ctgccggcca tctgggctgt 300 cggctggtgg tggtgctggg ccacacccac tgcggtgcag tggatgccgc catcaaccac 360 gagtccgccg gctatatccg ctacatcacg gacgagatca agaaggccat cggggatgaa 420 acagacccct acaaggccag ctgtctcaat gtccggcaca gtgtgcagga gattgaaaag 480 agcctgtgca tccataacat cgaggaggaa acgggcctgc gggtcgtcgg tgcgatgtac 540 cacatcgagg acggcagcgt cgaattcctg taa 573 <210> 343 <211> 1347 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1347) <223> BLCPAMOF_00289 <400> 343 atgagcgact ggaaaaagag gaacgaagat tggcgtgatg aggacgaact ggaagaagag 60 gaagaatgcg aatgcccttg ggtagacagc aagggcaaag tgcgtgaaac cgcttactgc 120 cagtaccttt tagagaagca ccccatgatg tgcctgaaac agaagctgtt tgaccagaac 180 ggcgaggtgg acgaggacgc actgctctac gaagtccaca gcgacctccg tgactttgtg 240 ctcgacaacc ttgctaagaa ggagaagcag gttctggacg cactccgtat cgaaacctat 300 acccctgaat ggaaacccca gcttgaccgc atccatctcc agaacggaac ctactttctg 360 gacgagcggg gctttgtgcc ggaaaaggaa ctctgcctga accggctccc tgtggaatac 420 cagcccgatg cccctgcacc gaccaagtgg ctggaatttc tggacggtct gctgatcccg 480 gaggacattc tgaccttgca ggaatatctc ggctatctcc tgatcccgtc taccaaggcg 540 cagaagatgc tggtcatgac cggcaagggc ggcgaaggaa aatcccgcat cggcttgctg 600 ctgaagaagc tgttcgggga agcctctcac tccgaatcca tcctccgcat cgaaacgaac 660 cgctttgcca gtgcaaatct ggagtataag ctggtcatgg tcgatgacga tctgaacatg 720 gtggctttgc ccgaaacacg gaacatcaag tccatcgtca ccgccgagga ccgtttgtgc 780 atcgagcgga agaataagca ggctgtccaa ggcttgctgt acgttcgttt catctgcttc 840 ggcaatggca accttgtggc cgctcacgat gacagcgacg gcttctggcg cagacagatt 900 cttatcacgg tgaaagaccg tgaccctgcc cgggtggata accccttcct tatcgaagag 960 ctgtcagagg agcgtcccgg catcctgctg tggatgctgg aagggttgca ccgtctgctg 1020 gcgaaccgct atcagttcac catcagcgag cgctccatcc agaaccttga agcagccatg 1080 gcggacagcg acaacctgac ccagttcatg caggcaacgg cgtatgtccg cttcaagccc 1140 gacaccgagg aacgctccac ctacctctat cgcgcctaca ccaagtggtg cgaggataat 1200 ctggaatcac ccgttccgca aaagaagttc agccagttcc tgctgaaaaa tgcagggaag 1260 tatggcctga ccttttccaa gcacatcgag ggaaagtacc gcggcttccg gggcgtatgc 1320 gtccaccccg cctttgctgc ggcataa 1347 <210> 344 <211> 90 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(90) <223> BLCPAMOF_01478 <400> 344 atgcaggctg cagcagatga cgatgtgctg gcctcttcgc tgaagctgat ggaccgcaac 60 aagcacgtat atgaggaact tgcaaaatga 90 <210> 345 <211> 108 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(108) <223> BLCPAMOF_00040 <400> 345 atgaacaacg ctctgacgga tcgatgtgtg aataaaccca acctcaccca cgcccctcac 60 cgggcttcgt cctttcgcct gtaccccgcc cattgggacg gagggtag 108 <210> 346 <211> 636 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(636) <223> BLCPAMOF_01475 <400> 346 atgaaacgaa aaaaattcct tgccctcgcc ctcgcgggcg tgatgaccgc agcgaccctc 60 accgcctgcg caccgctgga ggacctctac gactggttct ttggcggcgg gtcgagcagc 120 gcttcccgcg ggaacggcac aggccttgat gagtcggaga cgctcgaaaa tggcatcatc 180 cagtggtttg gacttcccag agccaacagg caaaaggacg aggcagagcc gatgcttcag 240 gaagtggcaa agagctttga cccggagagc tggcactaca acaacggcaa tctgaacggc 300 gagctgaacg ataccgccaa agccgcgctt gacaccatcg caaaggataa gctgacggag 360 actcacttgt ataagcgtac agcggtggat gtatgggagg tgcagcccag tcagacagac 420 tttgattttt ctgagaacag atggctttat tatgattggc ttgagcgggg cggagttcac 480 tcagatactc cgactcattc ctcgagttgg gagccttaca gcaggttgaa aagctcgata 540 caaagcacag acgcgtttga tttatacgcc ggtacgttcc aaaaaaacgg caaaacctac 600 gccgcaatgg ttatgattcg ttggagcaac agctga 636 <210> 347 <211> 690 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(690) <223> BLCPAMOF_00283 <400> 347 atggagcgtt caaaaatctt agtcgtggat gatgaaaagc tggtgcggcg gatgattgcc 60 cgcgtgctgg aaagcgaggg catgtccatt gtggaagcat ccaacgggct ggacgccgta 120 cagatggcca aggcccagcc ctttgacctc atcatccttg atattattat ggaggggatc 180 gacggttttc aggtcatcca ccagctgcga agcgagggga tgctgacgcc cgtattcatt 240 ttaagcggac gtcaggccga caacgacaag gtctttgcac tgggcatcgg ggccgatgac 300 tatatcacca agcccttctc accctcggtg ctctgcgcca aggtcaaagc ctgcctgcgt 360 cgaatgagtc tttccgctcc cagcagcagc ggcgtgctct ctgccggacc gttctgctat 420 ttcagtgacg agatgcggct attgaaaaaa ggcatcgaag tccctctttc cagcaaggag 480 agcttcctga tgaagtattt cctcaccaac cagaacaagg tgctgaccaa agagcagatc 540 taccacagca tctggggcga caatgtggta gacgacaaca ccattatggt acatatccgc 600 cgcctgcgca cgaaaattga ggatgacccc aacaagccgc tttatctgcg cacaatccga 660 ggcgtgggat accagttcgt ggcagaatag 690 <210> 348 <211> 1077 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1077) <223> BLCPAMOF_00282 <400> 348 atgaaaaaga tgatcacccg ccgcaacttt ctgaaggccg ctggcgtttc tgccgctgct 60 ctgggcctgg ctgcctgcgg cggttccggt tcgtctactg ccgcttcgtc caccgccggt 120 tccgctgcgg catcggccgc tgcttccgac tggacctggg agcgcaaggt cacgctggtc 180 tgcccctggg gcgtcggcgg cggtgctgac ggcaccctgc gccccctgca gcccgtgctg 240 gagcccatcc tgggtgttcc tgttgagatc gtcaacgtcg aaggtgcagg cggcgcaaac 300 ggcatcgact ttacctgcaa gcagcccgct gacggttata cttacgttct gggcacccag 360 tcccacatca tgctggacct gcagaagatc ctgcccgtgg atttcaagaa agagctgcgc 420 cccgttgcaa agctggtcca ctccatcaac atcatcgcct cttccaagaa ggcacaggaa 480 ggcaagtact ccaacttcac cgagttcgtg gactacgcaa aggcacatcc ccaggaactg 540 acctgcggca tgttgaccgc taccggcgcg gactctgtgg ctctgaagca gaccctggca 600 ggcggccttg gctgtgacat taccgaagtg gagcagtacg ttaaggtcgt caactacagc 660 tccggctctg agctgtccag tgccatggtc ggcggccata tcaacatcaa catcaccggt 720 gctgatgaga tcatgggcct catccagtcc ggcgacatcg tcccgctgat ctccatttcc 780 gaaaatcgca tgtccaccct gcccgatctg gagtgcaccg gcgagctggg catcgactcc 840 tacgttggta cctggcgcgg catcctctgt cgtaccgata cgcccgatgc cgccgtaaac 900 gccatggcag atgccctgaa agaagcatgg aacacccccg attatcagga gttcctgaag 960 aatgcctgct acctcgaccg tcccggctac gccgacgctg aagagttcca gcagcttatc 1020 gacgaagagt acaccacctt tgaagactac ctgaagggtg caggtctgat ccgataa 1077 <210> 349 <211> 522 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(522) <223> BLCPAMOF_00281 <400> 349 atggctctgg aactgatcgt caatctgctg ctgattgcgg gcggcatctt ctgctttgtc 60 aatgtcagta ccactatgcc ccactcggcc gtcaatgagc tgggtgccga gcagtggccg 120 caggctatcc tggtgctgat gctcatcgcg ttggcgttca acgtcatccg tttcttcaag 180 atcaataaaa aagaagatat caaggctggc ttccaggatt tctttcctgc catcggccgc 240 tttgtcaaga gcaagctttt cctcggcatg gtgctggtgg tggtcatggc gctgatgtat 300 gagccggtgg gttttatgct cacctgcctg ctgttcctgt ttgcctacgg cctgctgctg 360 ggccagcgga acatccccat gctgatcctc tcttccgtca tcatcaccat catcctgtac 420 atcggcttcg ccgtgtttct gggcgttctg ctccctcgcg gacagatcct ccccctacgc 480 aacttcgccc tgttcgttga gtcgctcgtc ccgcgtttct aa 522 <210> 350 <211> 1527 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1527) <223> BLCPAMOF_00280 <400> 350 atgctagatt tgttaaccag cggcctgtcg gtcgtttttg ccccgaagat gttcatcctt 60 atcatcttcg cggtcttcct tggcacgttg ttcggtgctc tgcccggcgt ttcggccacc 120 atggctgtca ccctcggcat ccccttcacc tataagatgg acgctgtcag cgccatcgca 180 ttccttgttg caatttactg cgcatccatc accggcggcg gcatgacggc catcctgttc 240 aagatccccg gcgtcccgtc ctccgccccg actacttatg acggttaccc catggcacag 300 cgcggcgaag ccggcaaagc tctgggcgta cagctcatcg cctcggccat cggcggcatg 360 ttcgcagccg tgtgtatgct gatcttcagc cctcagctga cccaggctgc cctgagcttt 420 ggcccctcgg aactgtttgc catctccttc atgggcctgt ccatcctgac aagcctggaa 480 gaaggcaatg tctgccgcac catcatctcc ggcctgctgg gtctgctgct ggcctgtatc 540 ggcctggacc ccctgctggg cgtgccccgc ttgaccttcg gcacccgttt cctcacctcc 600 ggcattgaaa tgatccccgt catgatcggc ttcttcgccg tcaccgaagt cctcaagcag 660 accaacaagc cttccaagct gaaggctgtc accggcaagg acggcaaggc ggatatgtct 720 gccaaaatgc ctaccctgaa agaaatgtgg agcctgaagg gtgtcatcgc ccgctgctcc 780 atcctcggca cggtcattgg catcctgccc ggtgcaggcg ctaccatcgc ttcgttcctt 840 tgctactcgg aagagcagaa gatctccaag caccctgaaa agttcggtac cggctgcctg 900 gagggcatcg ccgctcccga gtcaggcaac aacgccgcca ccggcggctc catggtcccc 960 ctgctgagcc tgggcatccc cggcggcaac gcggctgcca ttatgatgag cgctcttgtg 1020 ctcaagggcg ttaccatggg ccccctgctg ctggtcaatc agccccagtt cctgtcggcc 1080 acatttgctt ccatgtttgt ctccaacatc gtcatggtct ttgcagccat gatcatcgcc 1140 cgcatcttcg tgcaggtgct gaaaatcccc tacagcatcc ttggccccac catcatcatg 1200 atggcgacca tcggcgctta ctctaccaag aacacggcag ttgacgttat cctgatggcc 1260 atctccggcc tcatcggctt cgtcttctcc acctgcaagt tcaacagctc ggccatgatc 1320 ctcggtctgg ttctgggcgt catctgcgag tccaacctcc gccgcgcata caccatcgtg 1380 gccggtgata ccctgatgga agcaaccatc aatatcctga cccgccccgt caccgggatc 1440 atcatcctga tctgtatcct tgttttgttg agccccgtgt acaagcctct gctcaaaaag 1500 cataacaaag aagcagccgc gaagtaa 1527 <210> 351 <211> 267 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(267) <223> BLCPAMOF_00369 <400> 351 atgacagaag aagaaattga agcggccgca aaaaaggccg aatatgctgc gcttgatctt 60 gcgtcaaagt tgtttgctgt cgatgatgca cttgaaaaag cattagctca gaaactgcaa 120 tttgaaagcc tgtgcaaaaa aacatcaatt tcagataaaa caatcaattc gttcaagaag 180 gaagttctcc attacgtcga ttaccttgca gaaaaaatta ttagggaggc gctaaagaat 240 ggctcagatc gtgaagcgaa agaataa 267 <210> 352 <211> 642 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(642) <223> BLCPAMOF_01761 <400> 352 atggaatttc tgagtcggaa ggcagtttgg ctgcctcgct gggctgtttt cgtcagccca 60 ggtcggatac acctcactgg acgccacgtt ggcgatatag ctgcggaacg agacggtgac 120 gttccgggcc gaggcggcgg gcttgccgag gtggacggtg atgttcttgg ggatgatgac 180 ccggtccagc acccgcggca cacaggcgag ggcgggggtc gggccgctgc cgccgtcgcc 240 ggtgaagagg ctgtggggcg ggatgacgat gggggtgttg agggggtccc gcatctcctc 300 ggtgtcgggt atcatctcgg gctgggccag cgtcacctgc ccggggaaga cctgcacgcc 360 caggatgcgg acggtgcggt agccgggttt ggaggccaca aggctgcaga ccgcgtaggg 420 gggctgcgtg gtgttgttct cgtccagcga gagagcacag gctggggtgg taagggtgac 480 atcgtcggcg ttgccttcgg cgtcggtcag gcgggtggcg gtgaagccgt cgccgctgac 540 agtgacggtc acgccctcga cagggctgga ctgacgggcc gcaaaggcct ggatgcggag 600 agttccggtg ttcttcatgg agatacgctc ctttgctggt aa 642 <210> 353 <211> 345 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(345) <223> BLCPAMOF_01889 <400> 353 atgaagggca ggcataacaa aaaatctgtc cgcgtcgaat ttgtcatgtc cgaagcggag 60 gccgaactgg taaaagaacg catggcggaa cttggcatta ccaatctgtc ggcatatctg 120 cgaaagatgg ccgtagacgg ttacatcatt caccttgata tgggagacat tcaagaaatg 180 atccggcttc tccgcatttg ttccaataac ttaaaccaat ataccagacg ggccaatgag 240 accggcaata tttatgccgc agatatagag gacatccgca cccgtctgga cagactttgg 300 gatggcatgg acaaactgat ccggggattt gcaaacattt cataa 345 <210> 354 <211> 690 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(690) <223> BLCPAMOF_00680 <400> 354 atggagaaaa agacgagctg cctgctctgc gttcttaccg cgctgcttct cgctgtgctc 60 tatctctggg ccgctctccg cccgggcgtc tggctgcggg atgccttttt gtatcgtcag 120 gccgacggca gcttttcggg caaggatgcg tatgccgcct acaccatgca ggttgctcag 180 acggaaaacg gtgcggaagt ggagttcacg atagacggag agacgcggca ctatcggctc 240 gaatcgaaag ccgagggcat gagcgacccg ggcgtaaaaa ttgagcagga cggagtggtc 300 atttttaccg ggaccgcgct gggcgacccc ggcgacgcca tcctgtggag ggaagacgat 360 gggggccttg ccgacgaggt gaacgtcatc gtcaacggcg aataccagag atccgacctc 420 tggcccagct gtaactggct ctataatgtg gccgtcggcg ggcggcggga gacccggggc 480 agcgtggcgt tcctgctgcc gataggggcg ctggtggtgc tccttgtgct ggatgtccgg 540 ttcccgctgc tgttctggaa cctccgtcac gggctggaag tgtacggcgg tgagcccacc 600 gactggtatt acgcgatgca gagggtgagc cgcattgcca gcatcatcgg tgtttttgtg 660 ctggcggcga tgagctttgc tgttcactga 690 <210> 355 <211> 486 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(486) <223> BLCPAMOF_01882 <400> 355 atggaaaaat gggatttata taatgcaaaa cgggaaaagt ctggaataac agtgtgccgt 60 ggagaaatca tacccaaagg gctgtatcat ttatctgtga gtgtatggat cgtcaaccag 120 caggggcagt atcttttatc acagcggcat ccgaaaaagc aataccctct ttattgggaa 180 tgtacgggtg gttctgtact ttccggggaa accagtttac aaggagcaat ccgagaggta 240 aaagaagaat taggaatact gcttactccc ggaagtgaaa aattgattta tcagagcaga 300 cgggaaaatg tgcaggattt ttacgatgtt tggctatttc ataaggatat aaagattgaa 360 gaaatgcgtt tacaggaaac agaagttgtg gatgttcaat gggtaaatcc agataagtta 420 tttgagatgt ttcgcctgaa acatctgcac cctctaatta cctatgtaga tcagctaata 480 ggctga 486 <210> 356 <211> 669 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(669) <223> BLCPAMOF_01579 <400> 356 gtggaggaca tcttcttccg ctatgaggac accatgaccc actatagcgt ggacaagatg 60 gccgacgcgg cgggcgagga cgctgacgtg gagctgaagc agaacaggga ggacatcagc 120 ctccggctgg acggcgaaac gcgggacgac ctgtcggagc gctatcagga gtgggtgccg 180 gtgcagacgc cagagccgca ggagcggctg atattgaccc acgaaggggt agagcaaaaa 240 acgagtgaag agctcagacg tgaacgcgac gaattactga aacaagagct ggagatgatg 300 gacttccaac tcgcgaaaaa aagggacgac ctcccgagtt tggattggtg gctcgagcct 360 gcgagagagg aaacgccggg aatcgggctt gacgagtccc tgaaacagct ggcttcccga 420 tttgaggcca tcgctcccga ggaggataag ccacggcttt tcctgctgga aaccaccgtc 480 ccggatggca caaagtatac caatctgttg gagagtgacc tgcggagcta tgccgacctt 540 ggcgatgact gggaggacct gccggatacc cagggtgaga taaagctctg gataccggag 600 gacttggggc agcccaaaga aataagcatc tcaaaggaga gcctgagcag catcgacggc 660 attgcatga 669 <210> 357 <211> 1200 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1200) <223> BLCPAMOF_02285 <400> 357 atgaagcatc aatctctctc caaagtcctc aagcgtctcg cctgcgtgct ggcggcgctg 60 gtcatcgcgc tggctgtcgc cgtgttcgcc ctctggcaca acgagctggc caccctctcg 120 tccctcaaaa agctctctga ccgcgacgaa gcccaccgtg acggtgcagt ttaccagctc 180 aacgtctcgg gcggctacta cttcgacgat ttcctggccc agggcggcgc atccactgac 240 tctgagctca tctctttcat cacccagagc atcaccaagg gcatcatccc catgaacatc 300 aagaccagca ccatcgcctg ctcggccttt accgcagaca cccagagcgg cgaccgggtc 360 tttggccgca actacgactt ctcggccacc aacaccgcca tcgtctacac gaaccccggt 420 aagggtcgtc acgcctccta ctccaccatc gacctgagct tcctcggcct cgacaaggac 480 aaggatgtag agagcctcgg ccagaaaatc ctgaccctcg cggcccccta tgtgccgttg 540 gacggcgtca acgacgccgg tgtggcctgc ggcatcttca tgtcctatca gggcgagggc 600 aaaggcaccc ccaccgacac ccagaccgac aagcccgacc tcacctccac caccctgctc 660 cggctcatcc tcgactacgc cgactcggtg gaggacgctg tggcgctggc ccagcagtac 720 gaccttcacg actcggcaag cagctgcttc cactacatgg tggccgactc caccggccgc 780 agcgccgtcc tcgagtgggt aggtgctgat gccgaccacg acgccgacgg ctctcagcgt 840 cagctgaacg tcctctggaa cgacaccgac gccctctccg attcctccga ctggcaggtg 900 gtgaccaact ttatcaagac ctccggctac tacgacggta ctaccgtcga gatgaagggc 960 cttgaccgct acgagcacct tgcggctgcc ctgcgccaga ccaacggcgt cgtggctgac 1020 aagaacgctg ccatggacct gctggcttcg gtgggccgcc gcacctggaa caacgacgac 1080 tccaacagca acaccgtcca cagcgtggtc tacgatctga ctgataagtc tgttctctgg 1140 gtaggcaatg agcactacgg cgaggatggg tatacatttg agtttcagct tggggcgtaa 1200 <210> 358 <211> 759 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(759) <223> BLCPAMOF_02496 <400> 358 atggtaacag ggattgaaag ctttaaggaa tggttcaagg gtaacgaaag ccagtatgca 60 attatcggtg gaactgcgtg tgacatcttg atgacggaag aaggcttaga cttccgtgca 120 acaaaagaca ttgaccttgt tctaattatt gaagccgtgg atgcggcttt tggaagaaaa 180 ttctgggact atgtaaaaca ggctggatac gaacattgta ataaaagctc tggtatgccg 240 cagttttatc ggttcagtca cccgatgtca aaccgttatc cagcgatgat cgaactgttc 300 actagaaaac tggatgcaat tcaacttcca gatgatgcag tattgacacc gctgccaatg 360 gatgaggaca tatctagctt gtctgcaatc cttttggatg atgattacta tgagttcttg 420 aagcagggga aagtgactgt tgatggagtg acggttttgg atgctgcata tttgattcca 480 ttcaaggcga aagcatggat ggatttgacg gatcgcaaag aagctggaga acacgttgat 540 agtaaaaaca ttaagaagca taaaaatgac gtttttcgat tgactgaatt gattgaccct 600 acggtcaaga ttgccactcc cagtggcgtg tatgaggata tgcagaagtt tgttgatcga 660 atgaaaaatg aaacggttga tgttaaacag ttggggcttg tgggacgaac gaaagaacag 720 attcttcagg agataggaga attatatgct atacaataa 759 <210> 359 <211> 1530 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1530) <223> BLCPAMOF_00204 <400> 359 atggatttta gtctgcttct ttccagctat gctactgtct ggtccaaccc cgaggtcctt 60 ctgatgacct tcatcggcgc actgggcggc gttctgctgg gcgctatccc gggcatgacc 120 gccaccatgg gcgtggcgct gctcatcccc ttctccttcg gcatggacct catcccgtcc 180 atcggcctgc tgctgggcat ctactgcggc ggtatgtacg gcggttccat ttccgctatc 240 ctcatccacg cccccggcac gcccgccgca gccgccaccc tgctggacgg ctaccccatg 300 tgtaagaaag gtcaggccgg caaggctctg tccgtcgcta tgttcgcatc cttctgcggc 360 ggcgtcatcg gcgcactggt catgaccttc ctgtctccgc tggtcgctga tatggccatg 420 aacttcggcc ccggcgagat gttcatgctg gccgtcttcg gcctgtcggt catcgtcgca 480 atttccggca agtctgtggc caagggcctc atcagcgcct tcttcggtat gctgctctgc 540 accgtcggcc tcgaccccac caacggcatc ccccgcttca tcaccaccaa gcagaccggc 600 ctgctggatg gcttccagtt catccccact ctgatcggtc tgttcgctgt ctctgaagtc 660 atcgccggcg ttgagcgcat tatccgcggc gaagagcatg agcagaagtc caacgagaag 720 atcaccaacg tcctgcccga ttggaagacc atcaagaaga tctggcccaa catcctctcc 780 ggcggcctca tcggcacctt catcggcgcc atccccggcg caggcggtga catcgccgtc 840 ttcgtttcct acggcgccag caagtccgcc agcaagcacc ccgagctgta cggcaccggc 900 atccccaacg gcgttgctgc taccgagtcc gccaacaacg gctgctccgg cggcgctatg 960 atccccctgc tgtctctggg cgtccccggt gactccgtca ccgccatcct gctgggtgcc 1020 ttcatcatga agggcatcac ccccggcccc atgatgtacg tcaccgagct gcctaccgtc 1080 taccgcgtgt tcgcagctct gatgctggca aacctctgca tgctggtcgt cggctgcctc 1140 ggcgtccgct tctttgcaaa gatcgtctcc gtcgagaaga agatgctcta ccccatcatc 1200 ctcgtcatct ccctgctggg tgctttctcc atcaacaaga atgcctttga cgtgggcgtc 1260 tgtgtcgcct tcggcatcat cggctggctg atgaacaagt acgagttccc gctttctccc 1320 atcctgctgg ccctcattct gggacccatg tgcgagaaga acttcgtgcg ttacatgaac 1380 atccagcgcg gcaacttctt cgccatcacc acttctccca tcgcaatggt ctttgcaacg 1440 gtcgctatcc tggtcatcgt ctactctgtc tacaaccaga gcaagatcaa caagcgcacc 1500 gctgcaaacg ctgcacagga gaaggcataa 1530 <210> 360 <211> 537 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(537) <223> BLCPAMOF_00203 <400> 360 ttgaacaaag acaaaatgaa aacgatggcc ttctccaatc tggtaggctc catcattttc 60 ctcgcgatcg gtatctgggc gtggttccag accgataatt tccctgaggt ggccaacacc 120 tatgtgcagg cttccacctt cccccgcgtc atgatcgtgg gtatgctcat cttctcggtg 180 gtcctgctca tccagtccat cttcaagctg atgggtacca tgaagcccac cgaccccgtt 240 gctgtcgaag tcggcactct gaatcccctc aaggataagg gcgtggccgc tgcttacctc 300 gtcatgctcc tctgtgtgct gttcgctgct ctgttcaaga gctgcggcta catcctgtgc 360 gctgtggtgc tctcgatgat catcatgttc ctcatcggca agcgcaactg ggtgcagatg 420 gtccttgtga gcgttctggt gccgctgctg atgtggctgg tgttctacaa ggtgcttacc 480 gtcaatattc cgctgggtcc gctgaacttc ctgcgcaccc tcgtggacat gatataa 537 <210> 361 <211> 1047 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1047) <223> BLCPAMOF_00202 <400> 361 atgaaaaaga tctctcgtcg tgacttcctc gcagcttctg ctgctgtggg tgcagctggc 60 gtcctgaccg cctgcggcgg ttcttccagc agcactgcca cctctactgc agcttccact 120 gctgccagca ccgctgccgg cggcaagtct accgactacc ccaccaaggg tatttccgtc 180 atctgcccct ggtctgcagg cggcggcacg gactcctgcc tgcgcgcatt ctgcgaggct 240 atgggcaaga acctgggcgt caccctgact gtcgataacc agactggcgg cggcggcatc 300 ctgggccatc aggctatcgc agacgccaac accgacggct acaccatcgg tatgatcacc 360 ttcgagctgg ctacctataa gaagctgggc accagtgaac tgacctggga gaattacgct 420 cccctgtgcc gcgtcaacac cgacgcagct gccatcaccg tcggcgcaaa gtgggctgca 480 gacaacggca tcaccgacct gcccggtttc attgattact gcaaggctca ccccggtgag 540 gtgcagatgg gcggttcttc caacgcttct gtctggcaca tcgctggcgg ctacctgatg 600 agcgctaccg gcatcgacat ccagatgatc acctatcagg aaggcgctgc taccgctgtc 660 cagaacgcag ccggcggctt cattcagggt gttaccgtct ctctggccga agctcgcagc 720 ttcatcgagt ccggcgacct gatctgcctg ggcgtcatgg acgaagagcg caaccccgtc 780 ttccccgatg ttcctacctg caaggagcag ggctacgaca tcacctacta cacccagcgc 840 ggtatggccg ctcctctggg cgttgatgat gccatcatga cccgtctgga agaggcctgc 900 gccgctgcca tcgaggaccc tgacttcgtg accttcatga acaacaacgg tcaggcaatc 960 tcctatctgg atgcacaggg ctatgctgac tacctgaagc aggctgctgt cgatgtcgca 1020 gctgctatgg acgctgtcgg cctctga 1047 <210> 362 <211> 225 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(225) <223> BLCPAMOF_02493 <400> 362 atgaacatct ttgaagaaaa gaccgacagc gaactgcttt cctatttttc tgattatcaa 60 aagctgtgtt cccttgacaa atatactgga tttcaaaatc cagactttac ggctattctt 120 aaatcctatc gggagaagtt cggccctatt ggtgaaggag tccttggtca cgacttcttt 180 gaagctgttt tccatcgttg ggaaaagacc gtacataacg actaa 225 <210> 363 <211> 393 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(393) <223> BLCPAMOF_02825 <400> 363 atgagctttc cgcaggttct gaccggtgtg gcgcacattg gcatcccaac aaatgatctc 60 gacaagacca ttgcatttta caagaagctg gggtttgttt ctgcgctgga aacggtaaac 120 aaagccgccg gagagcgcgt tgcgtttctt cagcttggcg atctgatgat cgaaacttat 180 gaaaaccatc gtgcggcgga aaaggccgga gcaatcgacc atgtagctct ggcaacgacc 240 gatatcgaag ccgcctttgc tgcagcaaaa gaggcaggga tgcacctgct gcattccagc 300 atccagtcac tgccgttctg ggaaaacggt gtgcgctttt tcatggtcga aggcccgaat 360 aaagagagaa tagagttctg ccagaaatta taa 393 <210> 364 <211> 540 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(540) <223> BLCPAMOF_02752 <400> 364 atgttgagta atatgaatcg tcgtaaattc ctgaagctca ctggcaccgt ggtgctggcg 60 acatctgttg cgggagcact gggcggatgt agtggtggcg gtagcagcgc acctacaccg 120 ccctctcctg aagaagagag aatagcgcaa attatcctgg attcgatcaa tgctgcacgc 180 aaagaagttg gattggacgg cacagttcaa gaagtggata aaataagcca gctttcagca 240 cagcgtgcgc tggaaatgat gaacggaaaa aagcacgacg agctttcacc agttccgcag 300 gagttcaaag acggcggaaa aggctacaag tatggtggaa gggaaaattg gacagtaaca 360 ggacttccgc gagaccactt cacgaaaaat cagctgacag aatacttccg aaacaatttt 420 cagacggaac tgaatacacc cggtaagacg acgattcggg aagatgtata tgtaggaatc 480 agtgtgcagg aacagggtga ctatgtgtgg tatgatataa tctttgcaca cgagggatga 540 <210> 365 <211> 360 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(360) <223> BLCPAMOF_02713 <400> 365 atggcaagca agaaagtcga aatgtatgct aaaaaacgat atgaattaga tgaaatcaaa 60 aataaaatca aagaagaatt tgataaacgt aagttctccg atgtggaatt caaagacgaa 120 attatacgtg aattgggaga caccaaaaca ctactattaa tttttgaaaa ctggttttta 180 cgaacaggaa gttatgccag tttagtaatt atgttatccg agtatcaggg gtatcagagt 240 gcagatatta ttgccactgg tggtaaagaa gctttctttt cttttggtgc agaaggtgac 300 tttgcaaagt ttggagaaga tgctttggag aatttaggct ttcaaggaaa agttagataa 360 <210> 366 <211> 1161 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1161) <223> BLCPAMOF_02056 <400> 366 atgaatacta tgatgacttt agaacaactg cctcccaagg gtgtaaagcg agaacaggcc 60 attttggcgc tgggcaaaga ggaagcaaac ggcgaactgc ttctccagct tgtgaataca 120 gaaaagggca agtgcaaaac ggctgctcaa aaggctttgg cgcagctgga gtatgcccct 180 gctgccccac tgtgggccaa gctggtcaag ggcaaatgga tgggcagcca tatcatgtcg 240 gatgcctgct cggattgtgt atcggagcag attgccccag tcatcctgaa aaccctctcc 300 ctgctgttgg atgaggcgga tacaaaaccg ctggaagagg gacaggtgga acagatgaat 360 ttctgttttc atttgatgct gggcaaagcc tcccccaaga tgttggaggt gtaccgtttt 420 ctggcggaaa atgcggaacg gatcggccat ctcaagcaca ccccctttta tgatggtgac 480 aaatgcacta catggcacat ttcccaagga ctggggctct ataaagtaaa gccaaaggaa 540 atggagaaga ttccggcttt gattctgacc gcctccttga ttcgaaaccc ggatacacga 600 ctacaagcac tggccgatga actatatgaa cgctatggcg gcagttggct gattccagtc 660 tttatgaaag caattatcac ccagcccaag gaacaggtgt atgaaaccta ttcgctcctg 720 ctgggcactc ccaaagaaat ctacctgttc aatgctctgg ggatgctgga ttaccgctgt 780 tatccggagg actggatcta tgaacgcctg gggcctgatg gaatgactgc gttcatcttt 840 tggggccatg accgctacgg gtcctatgac acgaccttta tgtttgaacg ctatgtggag 900 ctggatgagc ggtggctttt tgatctggcc aaagaccctg aaggtcgaaa gcctacggtg 960 acttggcaaa gttacaaccg gagtggtgtt ttgtacgaaa gctacgacga aatgttcatc 1020 agtctgctgc cccgcaaggt ggaaaacccg gaactgaagt gcgttctgcg ggactacttc 1080 cgcatccgca gccagaaaaa gaaagtggct aagagcatca ccgtttacca ggatgctgcg 1140 gaacggttcg gagatgaatg a 1161 <210> 367 <211> 1128 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1128) <223> BLCPAMOF_02823 <400> 367 atgaccggca gcggagcaaa taaccgcgat gttaaaaaaa tcaaccgcat ccgaacgatt 60 cgcagcattt tttcctgcga ccgaatctcg cagccggagc ttgcggcaaa agtcaacaac 120 agctggccga ccgtattgca gaatgtcaaa gaactgatgg cgatgggact ggtgcaggag 180 gtcggcacct ttgaatccac cggcgggcgc aaggcgagag cattcgctcc tgtacgggat 240 gccagacttg cggtcggact ggagattacc cagaatcatg tcggagcagt tctggtcgat 300 ctgtccggta accttctccg ctatgagcgt aaaaagcgtc tttatgagcg gtcggacacc 360 tatgcggaaa tgcttgccgg aatcgtgcag gggctgatcg aaaaagaggg ctacccggtg 420 gaaaaaattc tgggtgtcgg catttcgctg cccggtattc tggacaaaga ggggcagaca 480 ttggtttact ctcatgcctt gggtctgcgg aatgttccta ccgaagaatt cagccgttac 540 atcccgttct cctgccggtt catcaatgac gcgaacgctg ccggacttgc tgaagtgcgc 600 gacctcgaat ctccccgcag ccttgtctac ctttctctga gcaacagtgt cggtggtgcg 660 attctgaccg gtggagcgct ctatggcggc gaccatcttc gtgccggaga gttcgggcac 720 aacacgctcg ttcccgatgg ccgcccctgc tactgcggaa aaaagggctg tctggatgcc 780 tattgctctg caaaagtcct ctcccgactg actgacggaa atcttgcact attctttgat 840 gggttgcgct ctggcgatgc agctttgcaa acggcatgga atgaatacct ttcttacctt 900 gctgtagcag tcaataatct gcgcatgacc ttcgactgtg atgtaattgt tggcggctac 960 gttggcggat ttctggcaga gtttggcgaa ccgctccggg aaatgctggt cgagcgtaat 1020 acgtttgagc cggacagttc ctacctgaag ttcagccgct ataagctgga agcctctgcg 1080 ctgggagccg ctctgctcca tatcgaagcc ttcattcaga acctataa 1128 <210> 368 <211> 651 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(651) <223> BLCPAMOF_01871 <400> 368 atgagtaata ttttgaaatc cacaaaatta gatattgcat tggtaaaacc atattttaag 60 acgatttgct ttaccctgct tctgccgatt gtgtttgccg caatcaaccg ttctttgctg 120 acaggggtat catttgccat gtgctttatt gctatgacga cgggatatac cttttccatc 180 acagaaaaaa acagcatgga tcggctgttt ggtattttac ctgttcggaa aagcgagctt 240 gtgatcggac gctatgtttt cgtccttgca atggggcttc tttccttgat tatttctttg 300 attgcacagc cgcttgtctt gaaagtgctg ggtgaaacag ttggcgtatt tgacattgta 360 actgccgcta ttgcaggagt attcttattt gcactctata ccgtgttcca gattccggga 420 tattacaagt acggttcaat caaaggacgg gtatttatgt atattccagt ggccggtttt 480 ttggtgactt tacttcttct ctctaaaatg ccagccatcg ggaaatcaat tatttcagtc 540 gttgaatctt ctccgatact tctcgttttc cttgcggttt ttgctattgt cgtgatgtat 600 gcggtttcga tcttcttgtc cattcggatt atgaagaaca aagaaatgtg a 651 <210> 369 <211> 114 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(114) <223> BLCPAMOF_01870 <400> 369 atggatttca caattttggc agttgtgctt ttgcttggtg ttggcgttcc tatccgtaat 60 aaactcatac ggaaatatcg ggataagaaa aagaatgatc gcaattcgga gtga 114 <210> 370 <211> 837 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(837) <223> BLCPAMOF_02653 <400> 370 atgtcagtac aaacagattt cgagaaagaa tttgaaacag aagaatatga aatgcttatt 60 ttagtacaag catcatgtgg gggagcagta tgtataaaag atatgctgaa accatcagtt 120 gattttcttg catccataga tttgcgcaat ggtcagtttt ttcatgagaa aggccgtgtt 180 gaatggctta taaaaaaaga taataaacgt aaggggtggg gatatgattt tgagcaattt 240 ggtatttatc gtgtcgttgt taggaaatgc atacctcaaa aattacaacc atatcaatta 300 cattatatga acaacagata tatgctaata agagtactgg aagaaaatgc ttcaaacgaa 360 aaattggaag ccttgaagga acattattca aaacctattt ctacggaaaa tgaattaggt 420 acttttgttt tggacagaga gttttcatgg tttgaaggaa gtataaattg gaatggtgta 480 gaggcaaatg tatatttgga aacagacgaa gaagatggag atactgctga acaggcaatg 540 gctgtcctaa aaagtgtaat tgagaatatt gtggataacg ataataagta tcgtgagttt 600 gcggcacaag aacttacagg acttgcaaat gagtggttga gtgaatcaga tgaaagcgat 660 gtagaagaaa ttacacaaga aacatttgct aaacgtatgg aaattagtga agtaacagtt 720 agtcccgatg gaagcttgtc attaatttat catgatgatg atatgttttg ggggcatatt 780 attgaaatag tggttgagcc aaatggagag attataagtg ctaatatagc cggatga 837 <210> 371 <211> 498 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(498) <223> BLCPAMOF_02107 <400> 371 ttgagcagcc tgggcaatct gttcggcctg ccttatgtgg tcatgcgtaa accggccccc 60 attgatacga cgactctgaa ctataattgg cagatctggg agaccaatgc gttcagcatt 120 tataccaagg aaacggacga agttggcgag cagagcgcac aggaagccgt tgctgccgtg 180 ctgcggtatc tcagccgggt cggtttactg cgataccact gccacagcgg gtatctgtcc 240 accgtcgtgc aggaaaacga gatggcaaat gtactcaccc cggcgggcgg gatcttccgc 300 cgcttcgtgg agccgggaca ggaagtggag tatggtcaga aaatgggcgt gatccttgat 360 ccgtttactg cggaggtgga agcagagatc acctgtccga ccagtggtgt tgttttcttc 420 gctttgaaaa aaccgctgac aacagaacat gaggtcgcat ttaaggtgat ccggcggctg 480 catgggggat gtttgtaa 498 <210> 372 <211> 2025 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(2025) <223> BLCPAMOF_01921 <400> 372 ttggcaggag tgcatgaaga tttcggcgaa aagatcggcg gtgcgaaaaa agacctgtgg 60 aaagaccgcg ggctgtatgc ggatgatctg gaagccatga atgagcgcga agccgaaaaa 120 tttgtgaaaa aggataatgt ctggaaaaag ccggactatg cagccatgct ggaggaaggg 180 attcctcttg gcgtggtcta ttttatcaaa aaagcgaggg acggcttaaa cgcttcccct 240 cagtattacc gcacggatga caccccggaa aaacggaccg cgagacaaaa ggaatatata 300 aaaacagtcc gggaattgca gacagtgctt tcagatgtcc gtactgtgga ggatgccata 360 agagcctatg accgcttttt cgctgacaat ggatacttag aaaaggtaca gggctgggga 420 agcggaatcc attaccgggc aacgaaaaag ggacaggaca atcccgtgat cacaaacaaa 480 ttgtccaata ccatgctgat ccgctcggct gaatattttg agcgcaactt tgctcagaaa 540 gcaaaaaagg aacagttttg tgtttccaaa gagcagaaaa taccgaaagg ttatgcgatc 600 cacttcaacg acgggaaaca gacctattct aaaaatgggg actggaaacc cggtacctac 660 tatgtgacaa aaggctattc gatcctgcgg accaattttg agaccaaaga agctgccctg 720 aaatgggtgc aggaacttgc caaaggcagg aacaaaaacg gaaagatccg ttttgtccct 780 ccacagcttg cccatgtcaa acgtaccgga ccggattatc ggaatggcgt ggagatcacc 840 ggacagcatt atcttgatac ctttgggttc cgcggcggtg agtttggaaa ctggatgaac 900 cagaacgacc ggcagacctc ccttaacatg ggatttgaag cactaaagga tctggcgtca 960 gcccttaaga tcagcgataa agatattgct tatcagggaa cacttgctat cgcttttggt 1020 gcaagaggca gtggcaatgc tgcagctcat tatgaacctt tgcgtacagt catcaatctt 1080 acaaaaatgc acggggccgg ttccctggca catgaatggt ggcatggact tgacgattat 1140 cttggtacaa agatgggagc aaaagggatg ctgtcagaac agccccacct ctatgcgccg 1200 ttccaaaaac tcattgacac catgaagtat aaaccggaaa caccggaaca ggcagcaaag 1260 cgcacggaag cacaaacaga acgcacccgg aaaaatgcgg caagctggct ggattcctcg 1320 gttcttgcct ccctgaaacg gtatggcaat gaggaacaga tggaaaccta cgcagtcttg 1380 cgggaagcat ttttgtccgg cgaacccggc tctgtggaac agatcagcgc atttaagaag 1440 aatgttaccg gccgggtaat tcccaaaagt gaacgggaac ggctggaaat ttttgagcgt 1500 atgctttccg ggatgcaggc gcaggaagct ccgcagattg gacggacgga aactgatttt 1560 taccgtaatt cggtacgcat gggaaaagaa tgtgaaaaag acggcggtta ttgggacagc 1620 aatgtggaaa tgacagccag agcctttgcc tgttatatca aggacaaact gccctacaca 1680 tcggattatc tggcaggcca tgccgactgt gcccttaccc tggtttccgg taaagacgga 1740 gaaatggagg tattgaaagc cttccctgtg ggggaagaac gccgtgcaat caacgctgtt 1800 tttgacgaga tcattcagga tttgaaacgg gaacagctat tgacccatgc cgatgtaacg 1860 cttcccctct ctgtttctga acttcgtgag gcggcggacg ggcagctatc catgttcggc 1920 gtcggccgtc cttccgtgat ggatcagctt gcggcaaaca ggccggcaga taaaaaatca 1980 ccggcacaga cgttttccag aaaaaaccac gagccggaaa tatag 2025 <210> 373 <211> 417 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(417) <223> BLCPAMOF_01878 <400> 373 atgaaaaaaa tcaatttttg caaagcaaca acaatcatct taataatcaa tgttatttta 60 tctattgttt tatttttcgt tgttcctgat aaaatagcaa ttcaatgggt aggtacatcc 120 cccagcaatg cagtagattc ttactatgta tttttggtgc cggtattgtc agtgcttttt 180 gcttttacgg gaaaacctat ttttacaatg ttcctgttta gattgtggaa tagaactaac 240 gagcatttag tgacatactt aaatttgtgt ctgcaagttg tatttcttac ttgtgaaatc 300 tatatcggat tatataacct atgtaatttt aatgttgcca ttagtataat tctcattgtg 360 gaacttatga tagatgtggt gattggattg aaattatttc acaatcaatc tatctaa 417 <210> 374 <211> 1944 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1944) <223> BLCPAMOF_00199 <400> 374 atgccggacg aaaagatgaa atatccactg ctggaattcg aatatgataa aaagctttat 60 gaggagcttt tgacgctgaa tccgcatccg gagtttatgg atagggtcag catcgtgaca 120 gaggattatg agcacgatga tttcgggagt cttcccggtg atgagaaaaa tgctctcggc 180 cacgcagcag gtgttttatg gaagattcaa aaatacggga cgtccttttc ggatgaagaa 240 agcaaaacca tccgaacgag aaaacgctca cgtacaaaaa agccagacct gttgttattc 300 gtaaacgatt tggaaaatga ttttcataat tactgtgctt gcatcaaaca tggcctcgga 360 aacaaagctg acctgtgtgc gctaacggag gctttgctct gttacggctg cgaagatact 420 gtatgggaag aagtcacaga atggcatacc gctgtgagcg agaataaaaa ctttgccaaa 480 tcaacatttc ttcccaactt tgacagactc tatatccgac aggcagaccg ttttttgttt 540 ctggagctca atactgagga agccctgaag ttttacgggc tggcaacaat gttgtgggac 600 catgagccgg acacaaaaga aacaaattcg gacgaccatt ttgtttcatt tacacgtcag 660 tatgaactct acagccgtat tttgaaaggt gcaagctatc cttatggcac atcctctcaa 720 ccatccgcat tttttcagtt gtataaccgt attattcact ccggaatttc gtcctcctct 780 ctttctgaaa agctgagtac cttcgtttta tccattcagg agataatgga gtctccatcg 840 tcccgaagcc tccatcgagc ccggcttgct ctgctgatgt ttatcgtcat aacaaaaaag 900 cattttatcc ctgagcttgc ccgtctttat gatgaccctg acagggagcg ctgggaagtc 960 gctatcatgg aaaaatcccg cctacttgag gataccggtt actctattct ttctcactat 1020 gcagcgcata tgacatggaa gtcggggaca cggtacttcg actcttatct gaggctggca 1080 aaagctgcat atctttcgga acttcttttg gatgaactga acgctgaggg ggatgcggcg 1140 gaaatcgctt attatacatc ggcagaagtt ttttcttata tgctccccga aaaatgcaca 1200 aaagaggagg ggaaagaagg gcgtctgggc aaattgaccg ttatgcatct gtcctatatg 1260 aatgacccaa acgaaggtaa aactctgcaa aaggcaattt acggcccatc gtatggagca 1320 cttcaaaaag gccgcaaacc tctggatgtt ccctttgtat ttgtaaaatg cttcagcccc 1380 cgcatcgact acctgcccat gtgggaaatg tatggcgacc acgccagagg ctgctgtctt 1440 gtcatcgact gggaaacatc aaaatggatg gaagaagaag ccgagcctgt tctctatcac 1500 gtctgttacc ttcggaaaca gggaaattcg tatgtagtct tgaacgaaga caatgaaaag 1560 ctttcccgct cctgccgcgc cataaattca cagctccagg aactgcacaa tgtcgccgag 1620 gaaatcgcag aacaggaccg ccgttatctc gatgatgtcc tagggaaagt cctctacctc 1680 ttcaaagaca gcagctacag ctacgagcaa gagctgcggg tcatctacca gacgaaggac 1740 aacatcctcc atactgacgg cgacagaccg tggcttttcg tgcagacacc ttttcctctc 1800 caattagacg aagtcattct gggcccgaag ttcccggacg tcagcacccg ggtgccttac 1860 ctgcaggagc agctcgacct gatgtgcgaa aagaccggca cggaaaagcc acgcatcacc 1920 ctttctgaaa tcgactaccg ttga 1944 <210> 375 <211> 135 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(135) <223> BLCPAMOF_00872 <400> 375 atgaaaacaa acgcaccttc tttgattttt ggcgcggctg ctttaataaa agaaacgaaa 60 ggagatagag tgaaaacgaa cgataccttt acgcttcagg ataagactct gctcagaaag 120 gaggcaaagc gatga 135 <210> 376 <211> 468 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(468) <223> BLCPAMOF_02577 <400> 376 atgctctccc tttacttttg cagggcagtc cgtgtggatt gtcctgcttc ttatatgagg 60 agaagacaga ttatagaagg gattaccttc agggtggacg gacaggaaaa gcttgccaat 120 cctgttaata cgatgatgtg ctttgaagaa gcattaaaag accatgcata tatcttgaaa 180 atgattgagg cacggatttt agtggagcac ggattgctga aggaatacaa ttttgacaca 240 gcaaaaatcg atacgcgccg agagaacatc aagagtgtat ttgattcagt atgtaatcga 300 aaacacacag atcaggaaat tcagaaggca tatgaagaag tattaaacgt agatattgaa 360 gggattcaag taaatccctt caaggcactt tactctgtct actccagggg tatcgccgca 420 acaacaatcc ccaaaagaag cggctggggg atggcatcct ctctctga 468 <210> 377 <211> 1089 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1089) <223> BLCPAMOF_02574 <400> 377 atgaaaaaga tttctcgtcg ttcgttcctg atggctaccg gtgttatcgc agcttctgct 60 gctctgagcg cttgcggcgg ctcctccgcc agcacctctt ctgccggttc taccgctgct 120 tccactgccg cttctggtac tgctgcacag ggcggcggcg acctcgtgat ctactcgccc 180 aactctgagg gcctgctgaa cgccaccatt cctctgtttg aggaaaaata cggcgtcaat 240 gtcgagctga tccaggccgg caccggcgaa ctggtcaagc gtatccagtc cgaaaagaac 300 gatccctacg cagatgtcct gttcggcggc tcttggtcgc tgatgtacac caacgaggat 360 ctgtgggagc cgtatgtttc cgccaatgat gcaaacgtca tagatgctta caaaaacaag 420 tgcggcttca tcaccggcaa cgtgctggac ggcagtgtcc tcatcgtcaa caccgacctc 480 atcggcgaca tcaagatcga gggctacgaa gatctgctga acccggctct gaagggcaag 540 atcgccactg ccgaccccgc caactcctct tccgctttcg ctcacctgac caatatgctg 600 cttgcaatgg gcggctacga ggacgataag gcatggcagt acgtccacga cctgtttgag 660 aatgtggacg gcaagatctg cgaaagctcc agcggcgttt acaagggagt tgccgatggc 720 gagtatgtgg tgggtctgtc ctatgaggat ccctgtgctc agctggttct ggacggcgca 780 cctgtcaaga tcgtttacat gaaggaaggt actgtcttcc ttcctgcttc cgccaccatc 840 atcaagggcg caaagaacat ggacaatgcc aagctgttca ttgacttcat cctgagcgag 900 gaagtccaga acatctgggg cagcaccctg accaaccgtc ctgttatgaa ggacgctgcc 960 accaacgatg ccatgacccc gatggcagac atcaatgtca tcgaagagga cattccctac 1020 gtcagcgccc acaagtcaga gctggtggac aagtacactg agatcttcac cgatctgcag 1080 agcaagtaa 1089 <210> 378 <211> 336 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(336) <223> BLCPAMOF_02479 <400> 378 atggaggtag atgaaacata tcaaaaaatg ttagaaaagc tgagagagca ttgcgaaaga 60 gaaaaaatgt cgatatatgc gttggcaaaa aatacaaatt tgtcaacttc cagcttaagc 120 aatttactta acggaaaaac aaaaccatat gtatacacgc tattactgat ctgtgatgcg 180 ctttcaattt caatcacaga tttggctgat aaggatgtat caatgacaga agatgaaaaa 240 tggataatat cttcttatcg aagtttgtca actaagaaga aagaaatgtt gacaacctac 300 ataaagatgc tgtcacagta tgaagaaaaa atgtag 336 <210> 379 <211> 1314 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1314) <223> BLCPAMOF_02474 <400> 379 atgaattttc taagaaccac aaaattgagg caggggaaaa cggtgaggaa cattaaatct 60 tctttagtaa taccacgact atcagttgtg gaaaatatta cgtttatact atcgatactg 120 ttgctgttta tgcaaccgct aaaaaatgct atttctatct tttcatatat tgatgaattt 180 gcagttctat tttcgtttat ggcatttgct tatactgtaa ttaggaggcg ttctataagt 240 actatagaag gaaagataat tgcttccttt ttgttgttta tcatagtcgg tttatttggc 300 aatactttat caaaggtcga tagaagcaca gcggcaatcc taacagatgt attgagctat 360 ggaaaattct ttatgatgat aatcggtgga gtggcattat tcgattcctt gaaaaattct 420 aagtggatat tttctattat tgttaaatta gttagatgct tggttgtggt ggggctaata 480 cttgctattt tgaatcaaat tattgatctt ggtatgagag atgatataag atacggtatg 540 tattgttttt cgtacatcta tgataccgca gctattttta gctggtattg ttacatgttt 600 atccttgttc tttctattga tctcttaaat ggagttaatc gaaaaagaat tatatttgtg 660 ctattaaaca tgtgcctttg gctatttacc ggacgcagta gaggattcgc tttttgcgct 720 atttacatta tgcttgtctt attactgcgt atgtatgaaa taaaacaaaa gcaattaaaa 780 ataaaaatag gatattttgt tatgctaggc ttgcttggcg ttatagttgc atggaaccaa 840 ttggtttttt attttactac aacaacagaa gcgagaagta tattattgta cgttggtatt 900 gatctattta aaaagtattt tccattaggt gcgggtcttg caaccttcgg tacagctgcc 960 gcacaaaaat attattcgcc agtatatgga atatatggat tgagtaatcg acatggcttc 1020 acatttgata atccactgta tttaactgat aatttttggc ctgctgttat tggggaaacc 1080 ggtttgattg gtttggtcgt ttttcttgtg actttgtatt ttgcctttaa atatctatat 1140 aaaaaatgca accaaaccaa tatgtctaga atgattatta ttttctttat agtgacaatt 1200 ctctcatcaa gtattgcgac atctatattt gcacaaaatg caacagttgc ggatattttt 1260 tatatatgca tgataccagc tattttgcga agggaaagaa tcatttatgg ataa 1314 <210> 380 <211> 228 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(228) <223> BLCPAMOF_00773 <400> 380 atggtatttc gtatgatttc gtttgagccg ctttggaaga cgatgaagaa aaaaggtatc 60 tcgcagtata aactcatcaa agaatacaaa atcagcacag gccagttgga caggctgcgc 120 aaaaacggga atgtcagcac ctacaccctc gaccagctct gccgcattct ggactgtggg 180 ctggaagatg tggccaccta ccaccctgac acggaggtaa agccgtaa 228 <210> 381 <211> 654 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(654) <223> BLCPAMOF_00079 <400> 381 atgaagctgt atcagaaact tatttctctg ctggtggctg cagtgatggc tgccgtgctg 60 atgccggtgt gcatggctgc tcccggcgac tccgttgaga cccgcatcaa caacgcgctc 120 gcacagcgca ccggcgcaga gctgtatcag gagatcgtca ccactgcccc cgatggcacc 180 acccagacca tgatcgcagc ccgcagcaac ggcaacgctt atatcaagat ggatatgggc 240 gacgccggca gtctggtcta tatcctgaaa gacggtcagg gctatctggt ggacgatgca 300 tccaagatgg ccgtcagagg cgaagtaccc actgtgagca caagcgagat agtctccgct 360 gacgaaggcg aagcacagga gatcccctgc accgtgacca ccgtgaatgt gaacggtcag 420 gactgcgagg ccctgtccta cactgccacc gatgccaacg gccagacggc caccgtttcc 480 tactgcctgg tcggtgatga cctcaagtat gtcgttaccg atgctgccga gggccgcacc 540 atcgtggagt accgcgtcac gagcaccact gtggaccaga atctcttcaa catccctgcg 600 gattatcaga tcctgacgca ggcagagttt gaagcggcac aggccaacca ctga 654 <210> 382 <211> 912 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(912) <223> BLCPAMOF_02471 <400> 382 atgtcgaaat tacttatagc atcaaagaat agtattaaat atttcattag caaatgcacg 60 gattttgttt atttacagag gtggaaaata gcgacacaac acccttgtaa gttgctgaat 120 aagcaaaaaa gaaaagaaga aataattgta agcttaacat catttcctgg aagaattcat 180 ttggtgcaca aaacgataca aactattttg ttgcaatctg taaaacctga tttggttgaa 240 ttgtggttgg ctaaagaaca atttccaaat tatgaaaaag acttaccaaa tgaattaaca 300 aatttaattc aatatggatt aaaaatttgc tggtgcagcg attatcgttc atttaaaaaa 360 cttgttcctt cattgcaaga acatccggat gctataatcg ttacagcaga tgatgatgtt 420 tattatgcaa aagattggtt agaacgattg tatagtgcct atttagaaga taataatagt 480 attcactgtc ataaagcgac taaatttagt tacgaaaaag gaaaatttaa tgcaataggt 540 ggagggaaaa aatattatca taaagcatct tttttgaata aactggttgg tgtaggtggg 600 gtattatatc cggccaattc attagatggt gaagtcgtaa attcagaatt atttaataga 660 cttgcaccta ctaatgatga tatttggttc tggtttatgg caattaaagc agggacacga 720 ataaatgttg taaaaggtaa tcatcccaaa cctgtggatg cttatggaag ccagtctact 780 attaagttaa cagatattaa tgacaatggc gatatgttgt tctggtctca attcaatgat 840 cttataagct attaccctga gataagaaat gcattgattt cagagatgaa acagaactat 900 gtaagaggtt aa 912 <210> 383 <211> 273 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(273) <223> BLCPAMOF_00714 <400> 383 atggacgaaa acgaaaagaa agagccggag atgacacagg aaccgcctag gcccgaggac 60 tacagccgtt acatggggac cctgaaccgc atctaccgcc ggaacaataa cccgcagcgc 120 aaaaagctgg gcgacggcat cacttcgctg aaaaaggggc agcagtctgc cgcccctgcg 180 ccggagccgg gcaaaaaaga ccgcagcttc cttgctgtgg cgggcggagc catcgttctg 240 atggcgatcc tgtattttat caagctctta taa 273 <210> 384 <211> 1308 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1308) <223> BLCPAMOF_01710 <400> 384 gtgaaaataa aagctttgtc ctttgtcctc atggcggtgc tgcttttgtg cggctgtggg 60 cagaagagcg aaacggcggc tgcgaccccg gctcaggcgg tcacagcgtc tgctgcccag 120 agcagtacgg ttcgtccggt gagtaccggc gttacgccgg aacagttcgg ggcgaagggc 180 gacggtatcg cggacgacct gcaggctctg caggccgcga tgcagcaggc cagcgcgtcc 240 ggtcggcctc tcgagctgac ggcgggggcg gtctaccgct tctcctcctg cctcgggctg 300 cccagcggac tgaccatcca gggaaacggc gctgtcctgc tcagtgatat tcagtaccct 360 gacctgagag aggaccgtgt ggcggtggag cttatgaaag actctgatga tgaccgcgcc 420 cacgacgtcc ggctggaaaa tgtgaccttc cgggcagcgg acagctgtca ggccaactat 480 atgctccggg tgatgctcgc ccgcaatgtg gaatttgtgg gctgcacctt cgactgtgag 540 cccaacgagt gggggcgctg cgccgccgac ctgtatggcg gcaacgagaa tatccgtttt 600 gagggctgtg tgttccgcca gatgacctcc ggcgcgtccg gcggcatctg ggtgcgcaac 660 tggacggaca gggtggagag ccggaatatc cgcttccaga actgtgaatt ttacaagtcc 720 ggtgccgacg agctgctggc ggtctgggga tggggcggcg cggtgcggga tgtcgtcctc 780 tcgggctgca gcttctatga gacacagaca caggagggac tggatgccga tcatcgcccg 840 gtgtggttca tcacgctggg gcagagcggc accacagacg tccggatgga ggattgcacc 900 gtccgtgcgg agtattgcga gaccattttc cgtatggtag gcgataagac ccgcgccgtc 960 gtggacaact gcgacatcac catgagacag ccggacagca tggcaaagca cgatatgaaa 1020 aagggcgcga accccatgct ggcccggggc aatgaccgtg ccgacggcag cacggtcatc 1080 cagaacagcc gcatcaccct gagcggcgac aacgggcggc gcatctgcta tcagctcagc 1140 gccttgaaag gaaatacgct ggacgtctcc ctcggctacg gcatcgccag cacgaaggaa 1200 gtcagcggca acaccatccg gggccggata cggcataaag tctttcagga ctgctccggc 1260 gtggagaata acaatgtaga agtgcggaga ttctcgattc tgggatga 1308 <210> 385 <211> 1425 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1425) <223> BLCPAMOF_02497 <400> 385 atggaaaaga aataccaaat ttttatttcg tcaacttata aggatttgat agaagcacgt 60 agcaaagtaa gggatgcaat cctgtcaatg atgcatttcc cagttggcat ggagatgttt 120 aacgctgctg acgaagaaca gtgggaaatc atacaagaga cgattgatag ttcggattat 180 tatgttttga ttttgggaca gcgatatggc tctgtaatag aatctggatc ggatgctgga 240 attagctata cggaaaagga atttcgctat gcgagagaga agaaaattcc tattctggta 300 ttcataattg atgatgatgt ggcaattaag ccggaattta tggaaaaaga tccagaaagt 360 ataaaaaagc tggctgattt caagacagaa gctaaaaaag gacgaacggt acagtggtgg 420 actaatattg acgaacttgc tagagaggtt tcagaatctt tacatcagca aatggatcga 480 aaaaagcgtc cagggtggat aagaggagat gcctttgata ttgaagcaag tcatgcggaa 540 attctcagtt tgaataaaaa gataagagaa cttgagcagg aaaatgctga gctgaaatca 600 cagattgtaa agagggttcc tgagttgatg gccgcagttg tgctggatca acaggaggat 660 gaagaggagg atgaaaaagg tcttaaaaca catggaaaat tgcttattga tagctctgat 720 aatgcataca aaatccaatt atatcataat gatggagaat gctacaaaaa caagtatgaa 780 ccacttgatt taagttgcgt tgaatcacat ttaaaaaagt atgtaaaaga aaaggacttg 840 caggcttaca atgcagcact accgtctgaa gaagaaataa atgattatgc acacaagatg 900 agcgtatata agacaataac aaacggtggt gttgcgctca agctaagagt gcttaataag 960 ggaacagcga aagcaaccga cattagaatc tcaatcgtat ttccaaaaga tatttttgta 1020 tatgacattg atgatatcga aaaaatgaag gagccgaaag caccaaaact tccaccgaat 1080 cctattgaaa aggcagagga acgttttatg agcgacttaa atccagtata tggcttgttg 1140 aaaaatagta tggacggaat gcagccattc tactcagctc gaagcttgcc gattatagac 1200 ccggcaattt ttaacaactc caattcttct gtgtttgaat caatatctat acgagataac 1260 tcaatatttg ctgaatgcaa tcagttgcca cataaagatg ataccgagtt tgatgggata 1320 tatattgttc cggctagaaa aggaaaattc aaagtaagcg tttcactgat gtgttcggaa 1380 tatattgaac cgaaagttca tgatattgaa tttgaaattg tctaa 1425 <210> 386 <211> 414 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(414) <223> BLCPAMOF_01899 <400> 386 atgaaaataa aactgatcga ctttggcgtg ccggagcacc agcgtcctta ccgtccgcat 60 ggcaatgatg ccggagcgga tgtttatctg ccctatgact gtaccttaca gcccggagaa 120 atcgccaaaa ttcctttggg ttttggactg gaaataccgg atggatatgc gggatatatc 180 tttccccgta ccagcatggc ggtaaaaggt ctggtctgtg aactgccgcc tgtggattcc 240 ggctattgtg gagagatcca tgcgatcatc agcaatgtaa gcaatcaggc gcagtctctt 300 tttaagggag cccgtatcgg gcagcttgtg atcacgccga tcgtcattgc ggattttgta 360 accgatctgg gaacagaacg aggaaccggc agctttggca gtaccggcga atag 414 <210> 387 <211> 270 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(270) <223> BLCPAMOF_00373 <400> 387 atgaacgtat tcaccgaaat cagtacccgc gaactggaaa acaccctcaa gggcaaggct 60 gtccactaca tcgtcaacga tgcaggggaa gggctgtgct tattctttga gggctggacg 120 gacaacaccg gctcaaacca cggtgacgct atccacatca gcccggtcat tgatgcagct 180 ggcaagccgc agcttgttgt gcagtatgtc ccggaagagg aacggcccga agacagcgaa 240 acatgcaaca acggcgttgt gggtgagtaa 270 <210> 388 <211> 384 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(384) <223> BLCPAMOF_01894 <400> 388 atgagtgacc gaaaaacctt tgaatatggc ggttatcact tcacgcccat acgaaaattt 60 cacaaaaaag aaggcgactt tttcgtcata tcgaaacggc tggcaagtga cttcaactta 120 gggttgtgta cctatcagga tcggcaaaaa gcaccttatg attacaaaga cttttatacc 180 gtcgcaaccg acaaagaatg tgacattttc cggtgcgaag aaaatggttt gttgtatgtg 240 ccggggaaaa acgaactttt tatttaccat gaaccaaaac agaaaaagcg gaactctatt 300 gccgatgccc tttcacagtc caggaatgtt actgatataa ccggattttc cagcggccgg 360 caaagaagtg ccccggaaag gtag 384 <210> 389 <211> 387 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(387) <223> BLCPAMOF_00371 <400> 389 atgaaccaaa gacaacgggc attttgtgaa gcctacctca agtgtgggaa cgcagcggag 60 gcggcgagga aagccgggta cagtgccaga accgcccgga gcatcggcca gcggctgttg 120 acatatgccg acattcggga atatctggcc gaccgtaacg cggagatcat ggccgagaac 180 acagcgaccc ttgaagaaat ccgcagcttt tggacaacca caatgcgaga tcaggaggcc 240 aagcaggccg acaggctcaa ggcctccgag ctgctttcaa aggcgctcac tctggaacgt 300 gctgccgctg gcacgttgaa cccattcgac agcttgacgg atgaggagtt gcgcaggctt 360 tccgcgtttg atgatggttt agagtaa 387 <210> 390 <211> 126 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(126) <223> BLCPAMOF_01896 <400> 390 atgtggaacc tgatttcaca tttccttacc tttgccggag gaatggcttc cggcgttatg 60 ttgatgtgtc ttatgcaaac cggaaaactt gcggataaag aatttgaaac tatgaaggag 120 gaataa 126 <210> 391 <211> 921 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(921) <223> BLCPAMOF_01891 <400> 391 atggaaaaga aactgaccta tggtgtatgg gcggtacgaa gcagcacttc tattttcgga 60 ccggcacaaa gctggtgcaa ggaaaatgga aaaccgttgg aatttgatag caaagccgat 120 gctgaaaact atgcaaagga agccaacgag catacgacag caaatgtccg atactatgtg 180 aaagaaaaag aaccggaacc cggtgctgtt cggaaaggaa catctcaacc ggagctggat 240 gcacgcagcc atgaagaagt gacaccaaga aatgatgcat cggaaaaaca aaatgagatt 300 ccgggcagac agattccttc tcaaacagat ccgctggtag aaatccgctc tgcggttcat 360 agtaattacg caggcatggt cgctatgctg ggtgcggaca accgtgtgta tttggggcgt 420 gaggaacgct gccattgtca ggatatgcag ccatcttact atgacaatca ggatggttcc 480 ctgtgctttg tctgtgatca gcccgacatg tattattttc tttatggaga aggctgggcg 540 catacccaga cggaaatgct ggaacgaggg cttaccctgc gccagtatga agaatttgcg 600 agactgcaaa atggcgtcct tgcacagttt accacacaaa gagaaatcct gtttgccgga 660 cagccatttc aagcgccaga aagttatctt cgcaatgcgg aactttatga ggaaggacaa 720 accggcaact acaatatgct ggatggcagg ctgaacaacg aacctcttgt gcgtccggat 780 ctgacagatg gacagacgga tgaagaaatc cgggagctgg tgccggaagc aaagccgtcc 840 ttgatggacc gtctgaaagc agataaaccg gagcatgaag caaggcagat gatccctccg 900 gtgccggaaa gggaacgctg a 921 <210> 392 <211> 372 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(372) <223> BLCPAMOF_00375 <400> 392 atgccagacc acgccaaaca ggttggcgta ctgtgccagc acgttattga tctgctgggc 60 ttgaccatga aagaagggca gagtattcta ctcggtgaat ccaacattgc ccacatggtc 120 agcaaccacc cggcagatta tgccctgtat ggggagtata tcccgctgat tctgtctgcg 180 ccggactatg tagccctgaa tgcaaaggac agctcgattg aatacgtcaa ggaagttcag 240 gtaaacagca tatacgtcaa ggtggctgtc cgtgtttcgg ctcgtgggca gctctttgcc 300 cggtcgattt atcggctgaa cacaaaccgc gttctaaact ttatcgaaaa aggcacgttg 360 aagcggtatt ga 372 <210> 393 <211> 633 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(633) <223> BLCPAMOF_01892 <400> 393 ttgaatatca acacgattac tgcggaggat cttcgccgca tgccggataa ggaaggactg 60 attttacagg gctgtggcgg ggatctgaca gaatgggtag acggaatcaa tgaaatgctg 120 acacaggcag gcatattgaa agatggcagt cagtttgaga atgtgtttgc ttttcagcac 180 ggagaactga cctgtttgct ttacccgttt gatgatgtga aactggatat aggaaaactt 240 gccctgtggc gtttacagac ccatgaagtc tatggcggca catggctgtc ggactttgtg 300 ccgaattatt taggcggatt tatagaaaca ccggaagcgt tggcagataa accggattgt 360 ccactgatcg gagcagatgg gaacattttt aatctgctgg gtattgcttc ccgtactttg 420 cgggagcatg gtctgaaaga acaggcaaaa gaaatgtctg atcgggtatt tgcttccggc 480 agttatggag aagcgctctg tatcattggc gaatatgtca acatcacaga ttccgaaccg 540 gagcataaga attctctccg tcagcagcta aaagcaacaa aaccggcaga cccggtaaaa 600 aagcagcaaa cttccaaaca gcaggaacga taa 633 <210> 394 <211> 594 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(594) <223> BLCPAMOF_00272 <400> 394 atggaatttc cgggtgagaa tatagccgca acggttgccg agaaagtttc ggatatcgtt 60 atcgccaaaa tgaatattaa tgaagagaaa agaaatcgtg agtttaccta tcagctaaag 120 gaactcgaat tttacaaaag cggatatgat aaggaattac gggcactttt tgactattgg 180 acggatttgg tttggcttgc acaatttaaa gataatgaac tattgagcga acaggaaaga 240 aaacgctaca acaaacaatt cgatgacatg attaaaatag ataaaattgc aaagaacaag 300 attaatacaa tcaaatatgg aggaaaggaa accggacgag tcttagcact tcagtcaaag 360 ctgcaacaag caaaatataa agaccaacct atgctggtaa tggtttatat gtggtgctca 420 atcattgcag tactaaaaag agaaattttg ggtcagacca ttagcacaac agatattatg 480 caaatactta taacaaattt ggatgaaagc atggatgaaa taaaaaagtc tcaaaattat 540 atttctaagg tgtatcaaga aacttacgga gaactgccat attggacaga ataa 594 <210> 395 <211> 237 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(237) <223> BLCPAMOF_00273 <400> 395 atgaattatt tttacaatca aatgtttaat ccacaatatg taaaccctga ttattacgct 60 atgcttcaag cacaagccgc taaacagtac caacaaaacc agagcaatga ggtgcagaaa 120 gctgtgaaag caacatatga cttatgcgag gcagtcaaca aattggatgc agagcatcag 180 caacaagcat tctatgcctg tttgacagtt ttagctgctg aactgggttg gaaatga 237 <210> 396 <211> 105 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(105) <223> BLCPAMOF_01480 <400> 396 atgatccata ttctcacaat cctggagtct gccgtggcaa atataatttc acattatatc 60 tgcaagtggc ttgacagact cgacaaggac cgtaagcccg actaa 105 <210> 397 <211> 762 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(762) <223> BLCPAMOF_02480 <400> 397 atggacaaaa aattgtatga taaacgaaaa aaaccggatt gcaaaaaaga acaacagcga 60 aaagaaattt ttagtacata ttcggaattg tgtcctcaaa agcctcaaga taaccgcctt 120 tcgggtttgg aaactggaaa taaaaagaca ggtaaatctg gaagaattta tgacaaaata 180 ttagtatgga atatccctcc gagaatcact tgccccggag tatctgattg gtgctccacg 240 cattgttata atgcagatgc cagaaaagat gtttatacaa ttgaccgatg gtgtgaaaat 300 ctgtgggatt ttcattttcg gttacccgaa ctgaaggaca aaattgaaaa ccaaataaac 360 gaaaccactg gacgatgtgc ggttcgattg cattctagcg gagacttttt ttcagaagag 420 tacattgatt tttggaaaga aataatttta gaatttccaa aagtctcttt ttgggggtat 480 acaaggacat ggaatgtccc ttgcttaaaa gataatgtga acgagcttat gaatcttaat 540 aatatgcagc tgtttgcgtc atatgacaca acgatggcaa catcggttcc tgcgattcct 600 aaaagcttgg tctttgatac aaaagaaaat ttgtttgagt atgcggtgaa gcatacagat 660 agcataattt gcccggagca gtatggaaga gtggaaagct gcgctgactg cggcttgtgc 720 atgaagaaaa caaacaagga tattttattt cagttacatt ag 762 <210> 398 <211> 186 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(186) <223> BLCPAMOF_00276 <400> 398 atgaaaagaa aagcggtagt cgtttggcgt tcgtgtattt cgtccagacc ggacaagctc 60 aatgaagcca gcatctacaa gctctttgat gtacttgcgg gcggttcgct ctttgatacc 120 aagagctttc atcttaagcg caggaaactg aaaatcgcgg cttccagctg cttcattggc 180 ggctaa 186 <210> 399 <211> 108 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(108) <223> BLCPAMOF_01168 <400> 399 atgcaattct gccaaaagtg tttcgaggtt attgatttat tccacaaatt atgccatact 60 atagtcactg aaaccgttcc cgacaccgtt cccgaacaat ttcagtaa 108 <210> 400 <211> 858 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(858) <223> BLCPAMOF_01004 <400> 400 atggcgaata gcaaagtatg gaatgtgtta tatagagcta ctgaggattc agcatggaag 60 aaattaagag gtagaaaggg attttggtac gctgatccga ttttgttcaa aaaagggact 120 gatacatttc tatttactga agcatttaat aaaaaaatac aaaaaggtta cttagcaatt 180 tcgagaatgg agaatgaaga attttctgta cctcaaatta ttatgaaaag accttttcat 240 ctttcatatc catgtgtttt tgaatatgaa aacacagcat atatgattcc cgaaacggga 300 caaaatggta cattggaatt gtggaaagga tctgatgact taactaaatg ggagaaagta 360 tgcgtgttgt taagtcatgt aagatttgct gacacaaccg tttacattga agacggtaaa 420 gtatatcttt tctcttacga agaagcagaa aaatataaga cgcatatttt tttgctagat 480 atgaatagtt atcatataag agaaatcgag gagattactc atagtgagaa tatatatagg 540 cctgctggaa aattttatac tgaaagcgga agattattta ggcctgttca gtataatgta 600 aatagttatg gtgaaaaaat tctgattaat gaagtgaatt ccattcatcc gtttaaagag 660 acattctata aagaaataac cgcagataac tatttacaga atttaagagg ttgtaataca 720 catacctttt cgattgtagg tggtatttgt gcagtggatt acttagttga ggttaacctt 780 ccgatatttg aaagattagt tatcataaga aaaattcgta acaagttcta caaattgaag 840 tttaaattgg gaatataa 858 <210> 401 <211> 267 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(267) <223> BLCPAMOF_00279 <400> 401 atgaaattca aagtgcgtat cccactccag tatgttaagc ccgtctgtat cgccgccgtt 60 ctcgtgggca tctttgctgt tgcagcgggc agctggatca ccggcctgtg tctgctgctg 120 ggcgcttacc tgctggagaa aagctgctac cgctgccccc actgcggcaa aaagctggat 180 atgaagtacc cgctgttcaa gggcagctgc tgcccggcct gcaaggcaga gctgcgcccg 240 gcagcagaaa aaaacgccgc gaaataa 267 <210> 402 <211> 153 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(153) <223> BLCPAMOF_02814 <400> 402 ttgaaatact ttgaattcgg acaggagcac ccggaactga tggtgatgct ccacggcggc 60 gtatgctatc gtggcgcgct gacggtagct gagaaaatgg caaagaccta tcatgtggtg 120 ttggtggcct accctgagct tgtttgcctt tga 153 <210> 403 <211> 1248 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1248) <223> BLCPAMOF_01003 <400> 403 atgacattat ttactttgat atggggtgcc tgtatgctct atggatttac tcgaaagaat 60 atgaacgcaa tggttgcaat gacattgtta tttatgacat ttcaatgtgc gaatgtcata 120 agctttgggg gcttttctgt aggtccacaa attttaacat caatgtgttt gattgttaga 180 tttttaatat ttagtaaatt tagagtatac aaaaccaaat ataataattt agtcaatgta 240 ttgctagttg ttttagttat agaagtcatt atatctgctc tttataataa tgtgattagc 300 aaaaattatt tatatatatt acaattaaca acatatgtgc tctgctttgt ggtattaaga 360 tattcgtcta cgacgtttga tgaagtttca ctatatgaga tgttaagagg agttattatt 420 tttgttgctg tggtaggaat cctacagtgg ttagcgacta tggatatact tcctataaaa 480 cggattttga agatattgtt ttataacgat gatagtatga acatctattt taatgaaaat 540 gattactatc ataatagcag ggtttattcc acatttatgg agccatcata cttagcaggt 600 tttgctgttg gcgcttttta ctatttgcta agcttaaagg aaaaatggaa gagtaatacg 660 ccattattta ttattctttt gatagagatt gttctctcta ctagttctac agcatatgcc 720 gcaattgttt tggtaggagt tatttttatt gttaatgcaa gacagatcag tcttactaaa 780 aagtgtactt tagttttctg tgcgggtatt gcttttgccg ttttgtattt gcagtattat 840 gaattgttag aaaaagttct gtttaataag tggaattcta actctggcgt tgcaaggagg 900 ataatggata atgatgcttt aaacgctttt tactcatcaa aattattagg agtcggttat 960 aaatgcgttc gaggaagcag tgttttatat agtatgcttg gagaaatagg aattatcggg 1020 acggtcctat atacaacgac aaatgcagcc ttgtatattc ctattattaa taataggttg 1080 attagaagca aattgcctaa taattataca gctgttttgt ttggcttgct ttcagcgttt 1140 gtttgtttga tcatagcagt acctgacatt gatatgtgta catattggtt ttggatgtat 1200 tgtttggcaa tttgtatggg gtacaaaaaa acggatcctc agagttga 1248 <210> 404 <211> 291 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(291) <223> BLCPAMOF_02765 <400> 404 atgaattatc ctgtcgaata tactgtgatc acggaaaatg aaaaaatcta tattgagggc 60 ggcgccgatt attgggggct gttcaactac ctcatcggcg actatctgcg ggactcggtc 120 ctgagtgaga ctcgctcggc tgtctggaac agcgccaaga agggttctac tgagccgctg 180 cagaactggt tcaagaactt caagagcatg gggatcatgg gtatgatcgg ctacatctat 240 ggtatctacc acctgggcga gaagatcgat acttacctga ccaagaagta a 291 <210> 405 <211> 477 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(477) <223> BLCPAMOF_00724 <400> 405 atgccgaaca ttgttcttac gcggatcgac aaccgtcttg ttcacggtca ggtcgcaacg 60 cagtggtgtg gcgccattgg tgcaaacctt attctggtgg ccaacgacga agtggctggc 120 aacagcctgc gtcagggtct gatgaatatg gccgctcctg cctacgctgc aatgcgttac 180 tggaccgtcc agaagacgat cgacaccatc cacaaggcca gcgccaagca gctgatcttc 240 atcgtctgcg agaacccgca ggatgtcgtg aagctggtgg agggtggcgt tcccatcaag 300 aaagtcaaca ttggcaacat gcacatggca gaaggcaagc gccaggtggc aggttccgtc 360 gcagttgacg acgccgatgt ggctgcgttc aagcggctgc aggagcttgg tgtggaactg 420 gagatccgcc gcgttcctac cgaacacgct gaaaacatcg aaaagctgtt caagtaa 477 <210> 406 <211> 819 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(819) <223> BLCPAMOF_00725 <400> 406 atgggcttta gtgcacttca gatcattctg gtctttgtgt gggtgttcat cgtcgccatc 60 gaccagtttg atttcctgga atccctgtac cagcctatcg tttccggtgc tgtcatcggt 120 gcgatcctgg gcgaccttcc cactggcctc atcgtcggcg gtacttacca gctgatgacc 180 atcggcaaca tgcctgtcgg cggcgctcag ccgccaaacg cagtcatcgg cggcgtcatg 240 gctaccgtgt ttgcgatctc ttctcatctg gataccaccg ctgctgtcgg tctggcagtt 300 ccctttgctc tgatcggcca gtacatggtt accttcctgt tcaccctcat gtcccccatg 360 atgtccaagg ctgaccagct ggcagcaaag ggcgacacca agggcatcgt tcgtctgaac 420 tatctggcaa tggctctgct gggcctgctg ttcgccatcg tctgcaccct cggtatgctg 480 ggcggctctg caatgggtac taccctgagc aacctggctg ccaagtatgc atggatcatg 540 gctggtctgg gcgctgctgg cggtatgatg cgcttcgtcg gtttcgctac cctgctgcgc 600 atcatgcttt ccaacgagtt ctggggcatc tactttgccg gtttcgctct ggcaaccatc 660 atcggctaca tccccgagct gtccggttct gctctgctgc tgatcgcatt cgttggtatt 720 gcgatcgctc tgtatgacta ccagactcgc gttgctatca agcaggctgc tggttctggt 780 tttgctgcga atggaggcga cgacgaagat ggcatctaa 819 <210> 407 <211> 828 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(828) <223> BLCPAMOF_00726 <400> 407 atggcatcta atgcaactca ttacaacaat ctgactcccg cgcagccttt ggataaggct 60 acgctgaaca agatggtgct tcgttccctg aacctgcagg catccttcaa ctacgagcgt 120 atgcaggccg ccggctggct gtactgcatc ctgcccggtc tggagaagat ccacgcagac 180 aacaaggaag acctggagct ctccatggag cacaacctgg agttcttcaa cactcacccg 240 ttcctggtca ccttcgtcat gggcatcatc ctctctctgg agcagcagaa ggctgacatc 300 gaaaccattc gtgccgtgcg tgtcgccgct atgggccctc tgggcggcat cggcgatgct 360 atcttctggt tcactctggt ccccatcacc gcaggtatca cctcgaacat ggccatcaac 420 ggttcgctgg ctggccccat cctgttcctg ctgatcttta acatcgtgca gttcgcatgc 480 cgcttcttcc tgatgtactg gtcttacaac ctgggtacca aggcgatcga catcctgact 540 gccaacgcta aggagttcac ccgtgcagct tccatgctgg gcgtcttcat cgtcggtgct 600 ctgacttcca actacggcgg caccaccgtt gctaccgtca tcgagaacgg cgacagcccc 660 atcgttatcc agagcattct ggatggcgtc ctgcccaagc tgatccctct ggctctgacc 720 ctcggcctgt tcttcctgat gaagaagaag aactggaagc ccgttacctg catcgctctg 780 ctgctggtca tcggtctggt cggcgcattc ttcggcatct ttgcttaa 828 <210> 408 <211> 852 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(852) <223> BLCPAMOF_00721 <400> 408 atgtccttag ttacgaccaa agatttgatg ctcgacgctc agaagaacca ttacgccatc 60 ggcgcgttca atgccgagaa catggagatg gtgcaggcca tcatcgccgc tgctgaggag 120 ctgcgcgctc ccgtcatcgt ccagaccacc ccgggtactc tgaagtacgc ttctccggcc 180 atgttccacg ccatggtggc cgcagccgct tctgaggcaa gcgtccccgt cgtgatgcac 240 ctcgaccacg gcagcagcta tgagctggcc atgcaggcat tccgtgccgg ctacacctcc 300 gtcatgatcg acggctctca ccatgtgttt gaggagaaca tcgagatcac caagtccgtt 360 gtccgcgcct gccacgctgc cggtatcccg gtggaggctg agctgggcaa ggtcggcggc 420 aaggaagacg accttgacgg cggcaatggc aacggctaca ccgtcccctc cgaggctgct 480 gagtttgcag agcgcaccgg cgtcgattct ctggctgtcg ccatcggcac tgcccacggc 540 gtctacaagg gaactcccaa gctggatatg gagcgcctga gcgagatccg caaggtcgtg 600 tctgtgcctc tggtgctgca tggcacctcc ggcgtgccgg atgacgctgt ccgcgagtgt 660 gtcgcacgcg gtatgtgcaa ggtcaactac gccaccgacc tgcgtattgc cttcagcaag 720 ggcctgaagg aatacctcgc caaggacccc gaggtcttcg accccaagaa gtacagcgcc 780 gtcggccgcg agtacgtcaa ggaatacgtc aagagcaaga tcctggtctg cggcagcaac 840 ggcaaggctt ga 852 <210> 409 <211> 1434 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1434) <223> BLCPAMOF_00554 <400> 409 atgtcacctc tacattttgt gatcatgctg atcattgcga tcatcatcct gaccgtcctg 60 accctgaaat tcaagatgca cccggtcatg gttctgtttc tgacggccac cttctgtggt 120 ctggcctccg gcaagaccct cgtggacacc ttttcttcca tcaccaagta tttcggctcg 180 actttaggct ccattggtgt tatgattatt tttggtgcag tcattgcatc gggcatcaat 240 gacaccggcg ctgccaccag catggtcaac ttcttcatca agaagttcaa gggcaagtgc 300 ctcgagctgg ccccggccct gaccggcttc atcatgagca tccccgtttt cggcgacatc 360 gccatcatcc tcaatgctcc catttctgcc atccttgcca agcgcaagaa gctgggtatg 420 cagcaggtcg ctcccttcgt taacctcggc ctgaccctga cccacggtct ggtgcctccc 480 acccccggca tcctggcagt ggccatcctg ctgggcgctg acatcggcac cgtcatcatc 540 atcggcctca tctgctccgt catctccttt gccgtctgct acctcggcct gcgccccgtc 600 tacgccaagg gcgagtatgt tgctccgctg ccccagtaca ccgagggcat cgaggctgtg 660 gaagacacca acgatgtcaa cgccctgctc atcaaagagg acaacactcc cagctccggt 720 gcttccttcg ctcccctgct gctgcctgcc gtcatgattg ccatcggctc catcggcaag 780 ctgttcactg aagaaggttc cgccgcctac agcttcttca acaccttcgg caacaccgtt 840 ctggctctgt tcatgggcat catcgctgtc ggctgcctga tcttcggccg caaggacaag 900 gtcgtcaaga aagccaatgc tgacggcacc ggctgcaagc tgaccgagaa gagcagctgg 960 ttcgagatcg tcatgaacaa ctgggtaggc cgtgctctcc agatcgccat cggcgctctg 1020 ctcatcaccg ctatgggtgg tgctatgggc ggcatcctcc gcgagaacga agccatcgcc 1080 accatcggcg gcatgatcgc cgagagcagc ttccccgctg tgctcgtccc cttcctgatg 1140 gctgctatcc tgatgaccgt ctgcggctct atgaccaccg ctgcgatgac cgctgcaggc 1200 ctgatgggcg gcctgatgac cgttctgggc ctcgaccccg tcctcaccac tctggccatc 1260 ggtgcaggct ccatggtcgg ctggcatgtc aacaacagcg gcttctggat tttcacctcc 1320 ctgtacggct ttgataccaa gcagggtctg aagtacttta ccaccaccaa cgccctcggc 1380 ggcatcgttg ctttcatcgt gctggtcatc ctccacgctg tgggccttgt ctaa 1434 <210> 410 <211> 774 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(774) <223> BLCPAMOF_00746 <400> 410 atgaagacgc ttgctgcaag cctttccatc ctgacaagag aaggcgtcat gctctacctg 60 ctgcgcggcg tggccttcac ctgcatcatc tcggtgctgg gcgtcatcat gggcctcatc 120 gtgggctctc tgctggcgct ggcccgcacc tactgcaaaa agggtccgac ccgcatcctc 180 ggctggtttg ctaccgccta catcgagctg ttccgcaaca cgccctacct gctctggatc 240 ttcatctgtg tggtgttctg cccctgcccg ggcttcttcg cccgcaagat gttcggcctg 300 accagcgtgg agatgaagct tctgttcaag gccgctctgg ccctcatcct cttcaactcc 360 tccgtcatcg cggagatcgt ccgcggcggc ctgaacggcg tgtccaaggg ccagttcgag 420 gccggctatg cacagggctt caacaccgct gaggtgctgc tctacatcgt cctgccgcag 480 gcttaccgca acatcgtgcc gaccctgctc agccaggtca tcaccaccat caaggactca 540 tcctatctgg caaacgtggc caccatcgag ctgatggccc gcatccgcca gctgctgagc 600 gccgccggta cttacaacgg tctcggcacg gtgaacgtct ccgacgtcat ggtgctgttc 660 ggcacggcct gcgtcatcta cttcatcatc aacttcaccc tgagctgtgt ggtgcgcaca 720 atgcagaacc gccgcaagaa ggctctggtc tttgccccgg caaaggccgc ataa 774 <210> 411 <211> 741 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(741) <223> BLCPAMOF_00745 <400> 411 atgtctggct tgttttcgtt agagtcctgg tccaccgtct ggacgcatcg tgagagtttt 60 ctgctgggtc tgggcaacac gctgcagacc gccgtctgcg cactggcgct ggccttcatc 120 atcggcgctg cgctgggcct gatgtccacc agcggcagta agctgctgcg catcatcgcc 180 cgcatttacg tcgagttcgt ccagaacacc ccgctgctgc tgcagctgtg cttcctgtat 240 tatgcgctgg catttgcagg tgtgagcctc ggcgtcatcc gcaccggcat cattgcattg 300 ggcgtttaca ccggcgctta catgggcgag gtcgtccgcg ccgccatcga gtctgtgccg 360 aagggccagt tcgaggccgc acaggcgcag ggtttcaact atctgcagcg gatgggctac 420 atcatcctgc cccagagcat ccccgtgatg ctccctccga tggtcaacca ggtggtcaac 480 ctcttcaaga acacctcctg cctctacatc gtgggcggcg ctgacctcat cagcgtgacc 540 tacagcttcg tcaccggtgc ttccaccggc ggcgcatacg cccccgctta tatcgtctgc 600 ggcctcatct tcttcgtggt ctgcttcccg ctgtccacgc tggcagcccg ctgggaggct 660 tccctcaagg agcgcaaggg ccgtgtgaac ccgggtctca agaccgctgc caagaaagta 720 gagctgaagg aggctgcctg a 741 <210> 412 <211> 726 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(726) <223> BLCPAMOF_00743 <400> 412 gtgatcaaac tcgaacacgt tgacaagtac ttcggagacc tgcacgtcct caaagacgtg 60 aacctcgagg tcgccgaggg cgaaaagctg gtcattatcg gaccgtccgg cagcggcaaa 120 tctaccaccg tccgctgcat gaactttctg gaagagccga ccagcggcca cgtctacatc 180 gacggtcagg agctgaccaa caagaacaag accaggatcg tccgcgacaa catgagcatg 240 gtcttccagc agttcaacct ctacccccac atgacggtgc tcaaaaacct gacgctggca 300 cccatgaagc tccatcacaa gaccaaggca gaggccgaag agctggcata tcattatctt 360 gaggtcgtcg gcctccggga caaagcggat gtctaccctc cgcagctgtc cggcggccag 420 cagcagcgca tcgccattgc acgcgccctc tgcgcacaga ccaagatcat cctgttcgac 480 gagccgactt cggccctcga ccctgagacc atccaggaag tgctggatgt catggtaaag 540 ctggcacacg agaagaacat cacgatggtg gtcgtcaccc acgagatggg ctttgcacga 600 aacgtggccg accgtatcgt ctttatggca gacggccaga tcattgagga aggcacgccg 660 gagcacttct tcaccaaccc caagaacgag cgcgtccggc agttcctgag caagatcgtc 720 cgctga 726 <210> 413 <211> 588 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(588) <223> BLCPAMOF_01625 <400> 413 atgaccgaaa aagagaagat gctggcccat cagatgtacg acgcaaacta caacaaggag 60 ctgcacgatg agcgcatcgc agccaaggag ttgtgctggg agtataatca gctccgcccg 120 tcgaacgaag agggccagag agcggtcttg aagaaacttc tcggcaagac gggggagaat 180 ttctacatca ctgcgccgtt ctggtgcgat tatggctaca acatcgaact gggcgaaaat 240 ttctacgcca accacaacct ggtcatcctt gattgtgcta aggtgaaatt cggcgataac 300 gtcttcgttg cgccggactg cggtttccac accgctggtc accctatcga cttcgagcgc 360 cgcaacgccg ggtttgagta tgcctaccct atcacggtgg gggacaatgt ctggatcggc 420 gcaggcgtgc aggtgatgcc gggcgtgacc atcggcagca atgtggtcat cggcggcggc 480 agcgtcgtgg tgaaggacat ccccgataac tcggtggctg tcggcaatcc ctgccatgtc 540 atccgtgcca tcaccgatga ggacaaaaag acctggtgga gcagataa 588 <210> 414 <211> 357 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(357) <223> BLCPAMOF_01742 <400> 414 atggtaaata aagtgagagt gaccattgca ggcgcaccct acgccattgc aacgaccgat 60 accgagaact acatcaccac actggccaag aagctggacg atgacatcac gaagctgctg 120 gacaacaacg gcaacctctc tgtgaccaag gcggcggtgt tctgcgcgat ggactatctg 180 gacgagtacc gcaagagcgc gggcagcgcc gagaatatgc gcagccagat acaggactac 240 atttccgatg cagccaaggc gaagctggca gcggataagg tcaaggcgga gaacgagacc 300 ctcaagcggg aaaatgccgc actgcgggaa cagctggcca agctgcagca gaagtga 357 <210> 415 <211> 804 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(804) <223> BLCPAMOF_00307 <400> 415 gtgaggaaca tccggtggca gaagatggcc ctgcgggcgg cgaacggcct gctggacggg 60 gtgacggctc tgctggtgct gctggcggtg gtctggtcgg gctatgcgct gtgggacaac 120 agccgggtgt acgccgctgc cgacaatgtg caggccgggc tgttggcctt caagccccag 180 ccgcaggagg acaacagcct ctccttcggc cagctgcggg acatcaaccc cgatgtctgc 240 gggtggctga cgctggacgg cacggccatc gactacccgg tggtgcaggg cgagagcaat 300 ttcacctatc tgaacaccga cgtctacggc agctttgcgc tggcgggcag catctttctg 360 gatgttgact gcgacgcgga tttcagcggg cggtattccc tgctctacgg ccaccatatg 420 gagaacgggc ggatgtttgg cgacctcgac aaatacaagg acggcgcatt cttccgccag 480 aacaccaccg gcaccctgac gctgcccggc gggagctatc ggctggaagt gctggcctgc 540 cttgtggtgc ctgcgtcaga acaggccatc tttgccccgg gcaagtggcg ctcggacgca 600 ggcgggctgc tcccctttgt ggaggagaat gcccttcaga tggatgcaca ggcgctccgt 660 gcgctggaag aggagtcgga aggagcgcag ttcctggcga tggctacctg ctcgggggag 720 tacaccgacg cgcggacggt ggtgctggcc cggatggaac caatgtcaga cctgcaaaac 780 ggaaaggagg agagcttatc atga 804 <210> 416 <211> 1383 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1383) <223> BLCPAMOF_02826 <400> 416 atgagttaca cagcagagcc gaaacagcag gatacgaaca tcaaagtccc tctgatcagt 60 aaaatcgctt acggcatggg cgatgtgggc tgcaacttca gctggatgtt cgttggcaac 120 ttcttgatga ttttttacac cgatgtctgc ggcatcagca tggcggcagt gtccctcctg 180 atgctggtct cccgcttctg ggatgccatc aatgaccccg tgatcggttc gctgagcgac 240 cgcacccgtt cccgctgggg acgctaccgt ccatggctgc tgttcggcgc accggcaact 300 gctgtggtgc tcgtgctgac gttctgggcg caccccacat ggtcagacag tgctaagagc 360 ctgtatatgt acattactta ctgtgtactg gttctgggct acacttgcgt gaacatccct 420 tatggtacgc tctgcggcac cctgacccag aacatcgagg agcgtgcgaa aatcaacacc 480 tctcgctccg tctgtgccat gatcgccatc aatatcatca acatcatcac cctgcctttg 540 atctctgctt ttggcggtga taatgcagca cggggatatc ttctggtgac cgtcctttac 600 ggcggtatct tcaccctctg tcactggttc tgttttgcca aaaccaaaga ggtcgtccag 660 cccccggagc ggaaaaaagt ctcactgaaa aagcagttgg atgcagcgct tcagaacaag 720 ccctacctga ttgcactggc gggtcagttc ctgttcggtg tgacgctgta tggccgcaat 780 gccgacctgc tctattactt caaatatgtg gaaggcaacg agaatctgtt taccatctac 840 tcgatgatcc tgatcgttcc ctccattctg ggtgctgcgg cattcccctt cgtgtttgaa 900 aagctgggca acaaagggca cactgcttcc cttttcgctg ccggaaccgg cgtttccctg 960 attgcgctct atttcttcag tgcagtttct tctcccattc cgttctatac attcgctgca 1020 ctgtcccagt tcttcttctg cggattcaat accgccatct acgccatcgt tcccgactgc 1080 gtggagtatg gcgagtggaa aaccggtgtc cgcaacgatg gtttccagta cgcattcgtt 1140 tcactgggga acaagctggg catggcgatt ggcacctctg cgctggctgg tgtgctgagt 1200 gcattgagtt ttgcccccaa tcaggtgcag aatgctgccg tgcagaatgc gatgcactat 1260 gcattctcgc tgcttcccgg tgcgctgtgg ctggtaacag cgattgtcct gttcttctac 1320 cgaatcagta agcgttcgta taaccagatt atgtccgaac tgaacgctaa aaaagcaggt 1380 tga 1383 <210> 417 <211> 1002 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1002) <223> BLCPAMOF_02777 <400> 417 atgtatgctg catctcctgc acgctactcc accctgccct accaccgctg cggcaaaagc 60 ggcctgatgc tgcccgccgt ctcgctgggc ctgtggcaca acttcggcga taccgcgaac 120 ttcgagaaca tgcgcctgct ctgccgcacg gcgttcgaca acggcatcac ccacttcgac 180 cttgccaaca actacggccc cgagccgggc agcgccgaga agaacttcgg ccgcatcctc 240 aaggaagatc ttgcccccta ccgcgatgag ctcctcatca gcaccaaggc gggctacacc 300 atgtgggaag ggccttacgg tgactgggga agccggaaat acctgctggc cagcctcgac 360 cagagcctga agcggatggg cctcgagtat gtggacatct tctaccacca ccggatggac 420 cccaacaccc cgctggaaga gaccatgggt gctctggcgc aggcggtgcg cagcggcaag 480 gcgctttatg ccggcctgtc caactacaac ggtgagacgc tggaaaaagc ctgcgccatc 540 ctcgacgagc tccacgtccc cttcgtcatc aaccagaacc gctactccat ctttgaccgc 600 accatcgagc agaacggcct gaaagagact gctgtccggc tgaacaaggg cattatcgcc 660 ttcagcccgc tggcgcaggg cctgctgacc aaccgctacc tcaacggcat cccggaggac 720 agccgcatcc gcaccgatgg ccgctttttg aaagagagcg tcatcaccga agaaaagctg 780 gcacagatac gcaccctgaa cgaaatcgcc gctgcccgcg gccagacgct ggccgagatg 840 gcgctggcgt ggatactgcg ggacggcaag gtcacgagcg tcctcatcgg cgcgtccaag 900 ccccagcaga tcctcgacaa catcgctgcc ctgaacaaca ccaccttcac cgctgacgag 960 ctagaagcca tcgataaggc ttccggattt tacaaggagt aa 1002 <210> 418 <211> 1344 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1344) <223> BLCPAMOF_02538 <400> 418 atggatgttt ttgagagcaa accgctaaag ctggtcagcg cggcgtttta tatcgtgctg 60 atgttcctca gcttttactg tgcctgctac cgtctgccgg tgggtctgaa atatgccatc 120 aatctgttga tcttcgggtg ggcctgtgca atgttttttc tccgcccgat gttcaaccgg 180 gctatcttct gcctgcgctt ctttgcgctt ttcttttttc cctatctgat gttctggatg 240 tggtcggtgg ccatctggat ctcggagttc cagaccttca actacatcct gcgcggttcg 300 ctgaacattt tctatatgct cacgaacctg atgttcgcgt cggcggcggt ctacctgttc 360 ggtgaggcca ctatgcccct gacgctggtg ggcatgacga tggcgaatgg cttagtggca 420 ttgcaggtgg ctgcaagtgc aggcatcggg acttttattt cggagtacat tcgtctgctc 480 attacttttg cggacgacac cggcggtgcg atgcgccaga tggagctgca cgatatggtc 540 tacggctggg gcgtcatggt catctactac gccatccaca aggagaaaaa ccacaagacc 600 caggccgtct gcttccttat ctcggcgctg ttcttcacgc tgggtttcaa gcgcatcgct 660 gtcccagcgg tgttctgtgc ggcggtgatg taccatatcc tctgcaagtg gagaccgaga 720 catctgcagc tgcttacgga tgtcattgcg ctcgtggcag gcggctgcat ctttttctat 780 ctctggatga taaaatccgg tctgttcgtg gagctggcca atgaattcgg cgtcgatttg 840 atgtatcgcg acatccttta cggatatttc agccagttct tcgagctgct gccgacctat 900 atgggccgag gcatccgatt catctatacc tacgccaccg aagaccccag ctatccgctg 960 gccacggcgg ctacccacaa tgtctatctg gagctgtatc tggaagtggg cttctggtgc 1020 tggtggatat ggatactctt tgagctggca ttccgcatcc accgggtgga ggagcggtac 1080 accgagatac cggcctatgc gctgatggcg atgaaccttt atgtcttctt cacctacctg 1140 accgataata cttccttcta ttatcccatc aacgtcctgt accggatggc tattatggtg 1200 tggtgcctgg aaatttcgga aaacagtgag ctcgtcgatc ccgagagaga accactggcc 1260 gtggtgaagg aaagccgcca gaagaagcgg aacaaaaagg gaaaagaaga aaatgtggag 1320 gaagatttcc acatctgtgt ataa 1344 <210> 419 <211> 1089 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1089) <223> BLCPAMOF_02575 <400> 419 atgagcagaa tatcagtcaa agacgcagta aagcgctacg ggaataatac ggtcatcccg 60 gacctgaatc tggagatcgg agatggtgag ctgttcaccc tgctgggtcc ctccggctgc 120 ggcaagacca cccttctccg tatgatcgca ggcttcaact ccattgaggg cggcgacatc 180 ttcttcaacg agaagcgcat caacgatatg gaccccagca agcgcaacat cggcatggtg 240 ttccagaact atgccatctt cccgaacctc tccgtccggg acaatgtggc attcggtctg 300 aagaaccgca aggtggacaa ggccgagatc aagaagcgga cagatgagtt tctgaacctg 360 atgcagatca tgcagtatgc cgaccggatg cccaaccagc tttccggcgg tcagcagcag 420 cgtatcgcac tggcccgcgc actggtcatc tcgccggacg tgctgctgat ggacgagccg 480 ctttccaatc tggacgcaaa gctccgtgtc gagatgcgca gcgtcatccg ccacacccag 540 aaaagcgtag gcatcaccac cgtgtacgta acccacgatc aggaagaggc aatggccatc 600 agtgaccgta tcgccgttat gaaggacggc gtcatccagc acgttggcac tccccgcgac 660 atctaccagc gcccgaagaa tgtcttcgtt gccaccttta tcggtcgcac caacatcgtg 720 aatgcccacg tcaaggacgg catcatcacc tttgccgacg gctaccatga gcacattgac 780 gctctggaca aggctgccga gcaggatgtg cgctgttcca tccgcccgga ggagttcatt 840 atctgcaagg acggcaccga tggcatccac ggcaccgtgc aggagtgtac ctacctcggt 900 cttaacaccc actacaccat tgacaccgat cagggcgact cggtggagat cgtggaggag 960 tcctccattg gcgagggtct caagaagggc gagaaggtgc tgctgaaggt caagaaagag 1020 aagatcaacg tctttaccaa ggacggtggt accaatctca tcaggagcga cgcttatgaa 1080 aaacaataa 1089 <210> 420 <211> 309 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(309) <223> BLCPAMOF_00796 <400> 420 atggcaaatc cgagccggaa aaagcggaag agaaaggcgt ccgtcgtggg cgctgtgctg 60 aaactgctct tccttctgct tttgctgagt atgctggcgg cgtacatcgc aaatcaggtg 120 gcgctcagct ccaagaaagc ggagctggac accctgcagg agcagatcga ccagcagaag 180 acccagaacg aggagatgca gcgcatcctc agtggcgact cggacgacgt gaccgagtgg 240 gtcgcgcggg actcttacaa ttatgcggcg gccaacgagc gcatctttgt ggatgtgacg 300 ggcaactga 309 <210> 421 <211> 1062 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1062) <223> BLCPAMOF_02824 <400> 421 atgaaaggca caatgaaagt tgcagtcatg aacggcatcg gcaagatggg ctacaccacc 60 cgcccgatcc ccacacccaa agaggacgaa gttctggtca agctggaata cgttggcatc 120 tgcggcagcg atatgcacta ctatgaaacg ggtgcgatcg gcaattatgt agtcaagccg 180 ccgttcgtgc tgggccacga gccgggcggc acagtcgtgg aagttggcag tgctgtcaag 240 catctgaaag tcggcgaccg cgttgcgctg gagccgggca agacctgcgg tcactgcaag 300 ttctgccgtg agggcaaata caacctctgc ccggatgtcg tgttcttcgc tactccgccg 360 gtagacggtg tttttcagga gtatgtggcc catgaagcaa acctctgctt caagctgccg 420 gacaacgtaa gcaccatgga aggtgcgctg atcgagcctc tggctgttgg tttccacgca 480 gccaatcagg gcggtgctca tgccggtcag actgcggtgg tcatgggtgc aggctgcatt 540 ggtctggtct ccatgatggc gctgaaagcc gagggtgttt cccgtgttta cgttgtggat 600 atcatgcaga agcgtctgga taaggctctt gaactgggtg cagacggtgt gatcaacagc 660 cgcgaaaagg atgccgtcca aacgattctc gacctgaccg atggtctggg ctgcgacctc 720 gttatcgaga ctgctggtac agaaatcact acccgccagg ccattgagat ggcgcagaag 780 ggtgcaaaca tcgttctggt cggttactcc aaatccggcg agatgaccct gcctatgagc 840 cttgcactgg acaaggaact gaccttcaag accgtgttcc gttatcgcca catttacccc 900 atggcgatcg acgccgttgc ttccggcaaa atcaacctga agggcattgt gaccaacatc 960 tttgactttg acgacatcca gaatgccatg gacaagagca tttcggacaa ggccaacatc 1020 gtcaaagcag tggtgaagat tgcggaggaa acgaaggtat ga 1062 <210> 422 <211> 1149 <212> DNA <213> Faecalibacterium prausnitzii <220> <221> gene <222> (1)..(1149) <223> BLCPAMOF_00623 <400> 422 atgaagatcg ttgaagtcaa cacctatact gtccgtcccc gctggggctt tgttgagatc 60 gtgaccgacg agggcctgac cggctggggc gagcccgtgc tggaaggcca ctgcgccacc 120 gttctggcct gcgtgcagga gatgaagccc tacctcatcg gcaaggaccc catgcgcatt 180 gaggactttt ccgctgtgct gtaccgcgcc ggtttctacc gcggcggcgg cgtgctgatg 240 agcgccattg ccggcattga tcaggccctg tgggatatca agggcaagtt cttcaacgcc 300 ccggtctacc agctcatggg cggtgcctgc cgcgacaaca tgcgcgtgta cagctggatc 360 ggcggcgacc gccccagcga cgtgggcgct gctgctctgg agcgcaagaa tgccggcttt 420 accgccatca agatgaacgc caccgaggag ctgcagatga tcgacaccta cgacaaggtg 480 gacgccgttc tggagcgcgt ggccgccatc cgggagagct gcggcaagta tttcggcatc 540 gccatcgact tccacggccg tgtgcacaag cccatggcaa aggtcctggc caagaagctg 600 gaagagttcg accccatgtt catcgaggag ccggtgctgt gcgagaacat ggaggtgttc 660 aaggagatcg ccgctgcctg caatgtgccc attgccaccg gcgagcgtct gttcaccaag 720 tatgacttca agcgcctgct gcaggccggc ggcgtggaca tcatccagcc cgacctgagc 780 cacgccggcg gcctgaccga ggtcaagaag atcgcctcca tggccgaagc ctacgacgtt 840 gccctggctc cccactgccc gctgggcccc atcgctctgg ccagctgcct gaacgtggac 900 gccacctgct acaacgccgt gatccaggag cagagcatcg gcatccacta caacgtgggc 960 aagagcgtgc tggactatgt caagaaccag gacgacttca agttcgtaga cggccgcgtg 1020 cagctgcccg tccgtcccgg tctgggcgtg gacgtcaaca aggaactggt gctggaggag 1080 aacaagaccc cgcacgagtg gaagaacccc gtctggcgtc acaaggacgg cagcgttgcc 1140 gagtggtaa 1149 <210> 423 <211> 440 <212> DNA <213> Ruminococcaceae <400> 423 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggactggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 424 <211> 441 <212> DNA <213> Ruminococcaceae <400> 424 ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtgaagga agaaggtatt cgtattgtaa acttctgtcg cagatgacga aaagatgacg 120 gtaatctgta agaaagcacc ggctaactac gtgccagcag ccgcggtaaa acgtagggtg 180 ctagcgttgt ccggaattac tgggtgtaaa gggagcgcag gtggcagtgc aagttggatg 240 taaaatctac gggctcaacc cgtataagca ttcaaaactg tgcagcttga gtgaagtaga 300 ggtaggtgga atttccggtg tagcggtgga atgcgtagat atcggaagga acatcagtgg 360 cgaaggcgac ctactgggct ttaactgacg ctgaggctcg aaagcatggg tagcaaacag 420 gattagatac cccggtagtc c 441 <210> 425 <211> 439 <212> DNA <213> Ruminococcaceae <400> 425 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120 agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaatacaa gttgaatgtg 240 aaaactatgg gctcaaccca tagttgcgtt caaaactgtg tttcttgagt gaagtagagg 300 taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360 aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 426 <211> 440 <212> DNA <213> Ruminococcaceae <400> 426 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgagaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 427 <211> 441 <212> DNA <213> Ruminococcaceae <400> 427 ctacgggggg cagcagtgag ggatattggg caatggggga aaccctgacc cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120 tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240 gaaaactgtg ggcttaaccg acagactgca ttcaaaactg tttttcttga gtgaagtaga 300 ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 428 <211> 440 <212> DNA <213> Ruminococcaceae <400> 428 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acccaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 429 <211> 440 <212> DNA <213> Ruminococcaceae <400> 429 ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 430 <211> 440 <212> DNA <213> Ruminococcaceae <400> 430 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 431 <211> 443 <212> DNA <213> Ruminococcaceae <400> 431 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agaaagtgac 120 ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240 gtgaaatgca tgggctcaac tcatgagctg ctttcaaaac tgtttttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420 aggattagat accccggtag tcc 443 <210> 432 <211> 440 <212> DNA <213> Ruminococcaceae <400> 432 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaaccatag gctcaaccta tggattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 433 <211> 440 <212> DNA <213> Ruminococcaceae <400> 433 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaaccacgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 434 <211> 440 <212> DNA <213> Ruminococcaceae <400> 434 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaaccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 435 <211> 442 <212> DNA <213> Ruminococcaceae <400> 435 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga aaagatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 436 <211> 442 <212> DNA <213> Ruminococcaceae <400> 436 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agcaatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 437 <211> 442 <212> DNA <213> Ruminococcaceae <400> 437 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aataaatgac 120 ggtacctgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 gcaagcgttg tccggaatta ctgggtgtaa agggagcgta ggcggggatg caagttgaat 240 gtttaaacta tcggctcaac tgatagtcgc gttcaaaact gcaactcttg agtgaagtag 300 aggtaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctactgggc ttttactgac gctgaggctc gaaagcatgg ggagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 438 <211> 439 <212> DNA <213> Ruminococcaceae <400> 438 ctacgggggg cagcagtggg ggatattgca caatggaggg aactctgatg cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcggggacga taatgacggt 120 acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggggtgtcaa gttgaatgtg 240 aaatcggccg gcttaactgg tcgctgcgtt caaaactgac gctcttgagt ggagcagagg 300 caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360 aaggcggcct gctgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 439 <211> 440 <212> DNA <213> Ruminococcaceae <400> 439 ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtct tcggggacga taatgacggt 120 acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggtcggcaa gttggaggtg 240 aaagctgtgg gctcaaccca caaactgcct tcaaaactgc cggtcttgag tggtgtagag 300 gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 440 <211> 442 <212> DNA <213> Ruminococcaceae <400> 440 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attgatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 441 <211> 441 <212> DNA <213> Ruminococcaceae <400> 441 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaagaagacg 120 gtacccgagg aggaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg 180 caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240 tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300 ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 442 <211> 443 <212> DNA <213> Ruminococcaceae <400> 442 ctacgggggg cagcagtggg ggatattgca caatgggcgg aagcctgatg cagcgacgcc 60 gcgtgaggga agacggtcct ctggattgta aacctctgtc ggaagggacg aagaacgtga 120 cggtaccttc cgaggaagct ccggctaact acgtgccagc agccgcggta atacgtaggg 180 agcgagcgtt gtccggaatt actgggtgta aagggagcgt aggcgggatt gcaagtcaag 240 tgttaaatct atcggctcaa ctgatagtcg cgcttgaaac tgcagttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg cttttactga cgctgaggct cgaaagcatg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 443 <211> 440 <212> DNA <213> Ruminococcaceae <400> 443 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgttg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 444 <211> 441 <212> DNA <213> Ruminococcaceae <400> 444 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaacgagacg 120 gtacccgagg aggaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg 180 caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240 tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300 ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 445 <211> 441 <212> DNA <213> Ruminococcaceae <400> 445 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agtatgacgg 120 taccgaagaa ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaagca agttggaagt 240 gaaatgcatg ggcttaaccc atgagctgct ttcaaaactg tttttcttga gtgaagtaga 300 ggcaggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ctgctgggct ttaactgacg ctgaggctcg aaagcgtggg tagcaaacag 420 gattagatac cccggtagtc c 441 <210> 446 <211> 440 <212> DNA <213> Ruminococcaceae <400> 446 ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtct tcggggacga taatgacggt 120 acccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggtcggcaa gttggaggtg 240 aaagctgtgg gctcaactca caaattgcct tcaaaactgc cggtcttgag tggtgtagag 300 gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 447 <211> 441 <212> DNA <213> Ruminococcaceae <400> 447 ctacgggggg cagcagtgag ggatattggg caatggggga aaccctgacc cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120 tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240 gaaaactgtg ggctcaaccg acagactgca ttcaaaactg tttttcttga gtgaagtaga 300 ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 448 <211> 440 <212> DNA <213> Ruminococcaceae <400> 448 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggtaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 449 <211> 441 <212> DNA <213> Ruminococcaceae <400> 449 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agtatgacgg 120 taccgaagaa ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggggc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaagca agttggaagt 240 gaaatgcatg ggcttaaccc atgagctgct ttcaaaactg tttttcttga gtgaagtaga 300 ggcaggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ctgctgggct ttaactgacg ctgaggctcg aaagcgtggg tagcaaacag 420 gattagatac cccggtagtc c 441 <210> 450 <211> 440 <212> DNA <213> Ruminococcaceae <400> 450 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggtaa gttggaagtg 240 aaaaccatgg gctcaaccca tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 451 <211> 442 <212> DNA <213> Ruminococcaceae <400> 451 ctacgggggg cagcagtggg gaatattagg caatggggga aaccctgacc tagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aaaagatgac 120 ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240 gtgaaaggta tcggctcaac tgatatatgc gttcaaaact gcggatcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 452 <211> 442 <212> DNA <213> Ruminococcaceae <400> 452 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atatatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 453 <211> 441 <212> DNA <213> Ruminococcaceae <400> 453 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgatgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg taagggaaga gaaaggactg 120 taccttacaa gaaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaatgact gggtgtaaag ggagcgtagg cgggatggca agtcagatgt 240 gaaacctgag ggctcaacct tcagactgca tttgaaactg ctgttcttga gtgaagtaga 300 ggtaagcgga attcctggtg tagcggtgaa atgcgtagag atcaggagga acatcggtgg 360 cgaaggcggc ttactgggct tttactgacg ctgaggctcg aaagcgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 454 <211> 439 <212> DNA <213> Ruminococcaceae <400> 454 ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtcc ttagtgacga aaatgacggt 120 agctaaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagataa gttggacgtt 240 taatctatcg gctcaaccga tagtcgcgtt caaaactgtt tttcttgagt gaagtagagg 300 taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360 aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 455 <211> 440 <212> DNA <213> Ruminococcaceae <400> 455 ctacgggggg cagcagtggg gaatattgca caatggagga aactctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgttg tcagggacga tgatgacggt 120 acctgacgag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggagagcaa gttgggagtg 240 aaatctgtgg gctcaaccca caaattgctt tcaaaactgt ttttcttgag tggtgtagag 300 gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 456 <211> 442 <212> DNA <213> Ruminococcaceae <400> 456 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggggacga acacaatgac 120 ggtactcgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa aacgtaggtg 180 gcaagcgttg tccggaatta ctgggtgtaa agggagcgca ggcggaactg caagttgggt 240 gtcaaatcta cgggcttaac ccgtatccgc actcaaaact gtagttcttg agtagtgcag 300 aggtaggcgg aattcccggt gtagcggtgg aatgcgtaga tatcgggagg aacaccagtg 360 gcgaaggcgg cctactgggc accaactgac gctgaggctc gaaagtatgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 457 <211> 440 <212> DNA <213> Ruminococcaceae <400> 457 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaaccatgg gctcaaccca tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 458 <211> 443 <212> DNA <213> Ruminococcaceae <400> 458 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agaaagtgac 120 ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240 gtgaaatgca tgggctcaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420 aggattagat accccggtag tcc 443 <210> 459 <211> 439 <212> DNA <213> Ruminococcaceae <400> 459 ctacgggggg cagcagtggg gaatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtcc ttggtgacga taatgacggt 120 agccaaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaaagcaa gttgaatgtt 240 taaactatcg gctcaaccga taatcgcgtt caaaactgtt tttcttgagt gaagtagagg 300 taggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360 aaggcggcct actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 460 <211> 440 <212> DNA <213> Ruminococcaceae <400> 460 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaatccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 461 <211> 439 <212> DNA <213> Ruminococcaceae <400> 461 ctacgggggg cagcagtggg ggatattgca caatggaggg aactctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120 agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaaggcaa gttgattgtc 240 taaactatcg gctcaaccga tagtcgcgat caaaactact tttcttgagt gaagtagagg 300 taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360 aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 462 <211> 442 <212> DNA <213> Ruminococcaceae <400> 462 ctacgggggg cagcagtggg gaatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtgaagga agaaggtatt cgtattgtaa acttctgtcg cagatgacga agatagtgac 120 ggtaatctgc aagaaagcac cggctaacta cgtgccagca gccgcggtaa aacgtagggt 180 gctagcgttg tccggaatta ctgggtgtaa agggagcgca ggtggcagtg caagttggat 240 gtaaaatcta cgggctcaac ccgtataagc attcaaaact gtgcagcttg agtgaagtag 300 aggtaggtgg aatttccggt gtagcggtgg aatgcgtaga tatcggaagg aacatcagtg 360 gcgaaggcga cctactgggc tttaactgac gctgaggctc gaaagcatgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 463 <211> 440 <212> DNA <213> Ruminococcaceae <400> 463 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggatcggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 464 <211> 441 <212> DNA <213> Ruminococcaceae <400> 464 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agacggtcct ctggattgta aacctctgtc ttcggggacg aaacgagacg 120 gtacccgagg aggaagccac ggctaactat gtgccagcag ccgcggtaat acgtaggtgg 180 caagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggcaggc aagtcaggcg 240 tgaaatatat cggctcaacc ggtaacggcg cttgaaactg caggtcttga gtgaagtaga 300 ggttggcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc caactgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 465 <211> 442 <212> DNA <213> Ruminococcaceae <400> 465 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgtct tcggggacga acacaatgac 120 ggtactcgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa aacgtaggtg 180 gcaagcgttg tccggaatta ctgggtgtaa agggagcgca ggcggagctg taagttgggc 240 gtcaaatcta cgggcttaac ccgtatccgc gctcaaaact gtggctcttg agtagtgcag 300 aggtaggtgg aattcccggt gtagcggtgg aatgcgtaga tatcgggagg aacaccagtg 360 gcgaaggcgg cctactgggc accaactgac gctgaggctc gaaagtatgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 466 <211> 443 <212> DNA <213> Ruminococcaceae <400> 466 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attaaatgac 120 ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240 gtgaaatgca tgggcttaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420 aggattagat accccggtag tcc 443 <210> 467 <211> 440 <212> DNA <213> Ruminococcaceae <400> 467 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaactca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 468 <211> 440 <212> DNA <213> Ruminococcaceae <400> 468 ctacgggggg cagcagtggg gaatattgca caatggaggg aactctgatg cagcgatgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctttta tcagggacga taatgacggt 120 acctgaagaa aaagctccgg ctaactacgt gccagcagcc gcggtaatac gtagggagcg 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggatagcaa gtcagatgtg 240 aaaactatgg gctcaacctg tagattgcat ttgaaactgt tgttcttgag tgaagtagag 300 gtaagcggaa ttcctagtgt agcggtgaaa tgcgtagata ttaggaggaa catcggtggc 360 gaaggcggct tactgggctt ttactgacgc tgaggctcga aagcgtgggg agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 469 <211> 440 <212> DNA <213> Ruminococcaceae <400> 469 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aaacatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 470 <211> 440 <212> DNA <213> Ruminococcaceae <400> 470 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggggtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 471 <211> 442 <212> DNA <213> Ruminococcaceae <400> 471 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agatttgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggctcaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 472 <211> 442 <212> DNA <213> Ruminococcaceae <400> 472 ctacgggggg cagcagtggg gaatattagg caatggggga aaccctgacc tagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga agaagatgac 120 ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240 gtgaaaacta acggctcaac cgatagttgc gttcaaaact gcggatcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 473 <211> 442 <212> DNA <213> Ruminococcaceae <400> 473 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atagatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 474 <211> 440 <212> DNA <213> Ruminococcaceae <400> 474 ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtaca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 475 <211> 439 <212> DNA <213> Ruminococcaceae <400> 475 ctacgggggg cagcagtggg ggatattgca caatgggggg aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtct ttagtgacga taatgacggt 120 agctaaagag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggcg 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagacaa gttgaatgtt 240 taaactatcg gcttaaccgg tagtcgcgtt caaaactgtt tttcttgagt gaagtagagg 300 caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360 aaggcggcct gctgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 476 <211> 439 <212> DNA <213> Ruminococcaceae <400> 476 ctacgggggg cagcagtggg ggatattgca caatgggcgc aagcctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtct tcagggacga taatgacggt 120 acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggattgcaa gttaaatgtg 240 aaatctatcg gctcaaccgg tagctgcgtt taaaactgta gttcttgagt gaagtagagg 300 caggcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360 aaggcggcct gctgggcttt tactgacgct gaggctcgaa agtgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 477 <211> 440 <212> DNA <213> Ruminococcaceae <400> 477 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca tagattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaagaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 478 <211> 439 <212> DNA <213> Ruminococcaceae <400> 478 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcagggacga taatgacggt 120 acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc gggaagtcaa gttgaatgtg 240 aaatcgatcg gctcaaccgg tcgctgcgtt caaaactgat tttcttgagt gaagtagagg 300 caagcggaat tcctagtgta gcggtgaaat gcgtagatat taggaggaac accagtggcg 360 aaggcggctt gctgggcttt aactgacgct gaggctcgaa agtgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 479 <211> 440 <212> DNA <213> Ruminococcaceae <400> 479 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggggga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaaccacgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 480 <211> 443 <212> DNA <213> Ruminococcaceae <400> 480 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atcagatgac 120 ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240 gtgaaataca tgggctcaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420 aggattagat accccggtag tcc 443 <210> 481 <211> 440 <212> DNA <213> Ruminococcaceae <400> 481 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gcttaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 482 <211> 440 <212> DNA <213> Ruminococcaceae <400> 482 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcggtgacga aacaagacgg 120 tagccgagga ggaagccacg gctaactacg tgccagcagc cgcggtaata cgtaggtggc 180 aagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggagtgca agttgaatgt 240 gaaaacgatg ggctcaaccc atcgttgcgt tcaaaactgc atttcttgag tgaagtagag 300 gtaagcggaa ttcctagtgt agcggtgaaa tgcgtaaata ttaggaggaa caccagtggc 360 gaaggcggct tactgggctt taactgacgc tgaggctcga aagcgtgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 483 <211> 440 <212> DNA <213> Ruminococcaceae <400> 483 ctacgggggg cagcagtggg gaatattgca caatggagga aactctgatg cagcgacgcc 60 gcgtgaggga agaaggtctt cggattgtaa acctctgttg tcagggacga taatgacggt 120 acctgacgag gaagccacgg ctaactacgt gccagcagcc gcggtaaaac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc gggagagcaa gttggaagtg 240 aaatctgtgg gctcaactca caaattgctt tcaaaactgt ttttcttgag tggtgtagag 300 gtaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcggcc tactgggcac taactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 484 <211> 442 <212> DNA <213> Ruminococcaceae <400> 484 ctacgggggg cagcagtggg gaatattagg caatgggcga aagcctgacc tagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga agaagatgac 120 ggtacctgaa gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggtacg caagttgaat 240 gtgaaaacta acggctcaac cgatagttgc gttcaaaact gcggatcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtaa aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagtgtgg ggagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 485 <211> 440 <212> DNA <213> Ruminococcaceae <400> 485 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttggggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 486 <211> 442 <212> DNA <213> Ruminococcaceae <400> 486 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct tcagggacga aaggaatgac 120 ggtacctgag gaggaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 gcaagcgttg tccggaatta ctgggtgtaa agggagcgta ggcggggatg caagttgaat 240 gtttaaacta tcggctcaac tgatagtcgc gttcaaaact gcaactcttg agtgaagtag 300 aggtaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctactgggc ttttactgac gctgaggctc gaaagcatgg ggagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 487 <211> 441 <212> DNA <213> Ruminococcaceae <400> 487 ctacgggggg cagcagtgag ggatattggg caatgggggc aaccctgacc cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga aaaaggacgg 120 tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240 gaaaactgtg ggctcaacct acagactgca ttcaaaactg tttttcttga gtgaagtaga 300 ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 488 <211> 440 <212> DNA <213> Ruminococcaceae <400> 488 ctacgggggg cagcagttgg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtcc tcagggaaga taatgacggt 120 acctgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggtattgcaa gttgaatgtg 240 aaatctatcg gctcaactga taggctgcgt tcaaaactgt agtacttgag tgaagtagag 300 gcaggcggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcggcc tgctgggctt taactgacgc tgaggctcga aagcatgggg agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 489 <211> 441 <212> DNA <213> Ruminococcaceae <400> 489 ctacgggggg cagcagtgag ggatattggg caatgggggc aaccctgacc cagcgacgcc 60 gcgtgaggga agacggtctt cggattgtaa acctctgtct ttggggacga agaaggacgg 120 tacccaagga ggaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaattact gggtgtaaag ggagcgtagg cgggaaggca agttggatgt 240 gaaaactgtg ggctcaacct acagactgca ttcaaaactg tttttcttga gtgaagtaga 300 ggcaagcgga attcctagtg tagcggtgaa atgcgtagat attaggagga acaccagtgg 360 cgaaggcggc ttgctgggct tttactgacg ctgaggctcg aaagtgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 490 <211> 443 <212> DNA <213> Ruminococcaceae <400> 490 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga attagatgac 120 ggtaccgaag aaggaagctc cggctaacta cgtgccagca gccgcggtaa tacgtaggga 180 gcgagcgttg tccggaatta ctgggtgtaa agggagcgta ggcgggaaag caagttggaa 240 gtgaaatgca tgggcttaac ccatgagctg ctttcaaaac tgtttttctt gagtgaagta 300 gaggcaggcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gcctgctggg ctttaactga cgctgaggct cgaaagcgtg ggtagcaaac 420 aggattagat accccggtag tcc 443 <210> 491 <211> 440 <212> DNA <213> Ruminococcaceae <400> 491 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtgggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 492 <211> 441 <212> DNA <213> Ruminococcaceae <400> 492 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgatgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg taagggaaga ggaaggactg 120 taccttacaa gaaagctccg gctaactacg tgccagcagc cgcggtaata cgtagggagc 180 gagcgttgtc cggaatgact gggtgtaaag ggagcgtagg cgggatggca agtcagatgt 240 gaaacctgag ggctcaacct tcagactgca tttgaaactg ctgttcttga gtgaagtaga 300 ggtaagcgga attcctggtg tagcggtgaa atgcgtagag atcaggagga acatcggtgg 360 cgaaggcggc ttactgggct tttactgacg ctgaggctcg aaagcgtggg gagcaaacag 420 gattagatac cccggtagtc c 441 <210> 493 <211> 440 <212> DNA <213> Ruminococcaceae <400> 493 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtggggga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaatccatgg gctcaacccg tgaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 494 <211> 440 <212> DNA <213> Ruminococcaceae <400> 494 ctacgggggg cagcagtggg ggatattgca caatggggga aaccttgatg cagcgacgcc 60 gcgtggagga agaaggtttt cggattgtaa actcctgtcg ttagggacga taatgacggt 120 acctaacaag aaagcaccgg ctaactacgt gccagcagcc gcggtaaaac gtagggtgca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgcaggc ggaccggcaa gttggaagtg 240 aaaactatgg gctcaaccca taaattgctt tcaaaactgc tggccttgag tagtgcagag 300 gtaggtggaa ttcccggtgt agcggtggaa tgcgtagata tcgggaggaa caccagtggc 360 gaaggcgacc tactgggcac caactgacgc tgaggctcga aagcatgggt agcaaacagg 420 attagatacc ccggtagtcc 440 <210> 495 <211> 439 <212> DNA <213> Ruminococcaceae <400> 495 ctacgggggg cagcagtggg ggatattgca caatggggga aaccctgatg cagcgacgcc 60 gcgtgaggga agaaggtttt cggattgtaa acctctgtct tcggtgacga aaatgacggt 120 agccgaggag gaagccacgg ctaactacgt gccagcagcc gcggtaatac gtaggtggca 180 agcgttgtcc ggaattactg ggtgtaaagg gagcgtaggc ggggatacaa gttgaatgtt 240 aaaactatgg gctcaaccca tagttgcgtt caaaactgta tttcttgagt gaagtagagg 300 taagcggaat tcctagtgta gcggtgaaat gcgtaaatat taggaggaac accagtggcg 360 aaggcggctt actgggcttt aactgacgct gaggctcgaa agcgtgggta gcaaacagga 420 ttagataccc cggtagtcc 439 <210> 496 <211> 442 <212> DNA <213> Ruminococcaceae <400> 496 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga agatttgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagc aagttggaag 240 tgaaatacat gggctcaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 497 <211> 442 <212> DNA <213> Ruminococcaceae <400> 497 ctacgggggg cagcagtggg ggatattgca caatgggcga aagcctgatg cagcgacgcc 60 gcgtgaggga agacggcctt cgggttgtaa acctctgtca ttcgggacga atatatgacg 120 gtaccgaaga aggaagctcc ggctaactac gtgccagcag ccgcggtaat acgtagggag 180 cgagcgttgt ccggaattac tgggtgtaaa gggagcgtag gcgggaaagt aagttggaag 240 tgaaatgcat gggcttaacc catgagctgc tttcaaaact gtttttcttg agtgaagtag 300 aggcaggcgg aattcctagt gtagcggtga aatgcgtaga tattaggagg aacaccagtg 360 gcgaaggcgg cctgctgggc tttaactgac gctgaggctc gaaagcgtgg gtagcaaaca 420 ggattagata ccccggtagt cc 442 <210> 498 <211> 443 <212> DNA <213> CAG-41 <400> 498 ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggatcgtaa actgttgtcg caagggaaga agacagtgac 120 ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240 gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300 gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 499 <211> 443 <212> DNA <213> CAG-41 <400> 499 ctacgggggg cagcagtggg gaatattgcg caatggggga aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga agaaagtgac 120 ggtacctcgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgg caagtcagga 240 gtgaaatacc ggggctcaac cccggggctg cttttgaaac tgccagcctt gagtatcgga 300 gaggaaagcg gaattcccag tgtagcggtg aaatgcgtag atattgggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 500 <211> 443 <212> DNA <213> CAG-41 <400> 500 ctacgggggg cagcagtggg gaatattgcg caatgggggg aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga ataagatgac 120 ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240 gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300 gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 501 <211> 443 <212> DNA <213> CAG-41 <400> 501 ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga agacagtgac 120 ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240 gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300 gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 502 <211> 443 <212> DNA <213> CAG-41 <400> 502 ctacgggggg cagcagtggg gaatattgcg caatggggga aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga agaaagtgac 120 ggtacctcgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggaccgg caagtcagga 240 gtgaaatacc ggggctcaac cccggggctg cttttgaaac tgtcggcctt gagtatcgga 300 gaggaaagcg gaattcccag tgtagcggtg aaatgcgtag atattgggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtgtg gggagcaaac 420 aggattagat accccggtag tcc 443 <210> 503 <211> 444 <212> DNA <213> CAG-41 <400> 503 ctacgggggg cagcagtggg gaatattgcg caatgggggg aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg cgagggaaga aggaagatga 120 cggtacctcg tgagaaagtc acggctaact acgtgccagc agccgcggta atacgtaggt 180 gacaagcgtt gtccggattt actgggtgta aagggcgcgc aggcgggcag gcaagtcagt 240 cgtgaaatgc cggggctcaa ccccggagct gcgattgaaa ctgcaggtct tgagtatcgg 300 agaggaaagc ggaattccca gtgtagcggt gaaatgcgta gatattggga ggaacaccag 360 tggcgaaggc ggctttctgg acgacaactg acgctgaggc gcgaaagtgt ggggagcaaa 420 caggattaga taccccggta gtcc 444 <210> 504 <211> 443 <212> DNA <213> CAG-41 <400> 504 ctacgggggg cagcagtggg gaatattgcg caatgggggc aaccctgacg cagcaacgcc 60 gcgtgcagga agaaggtctt cggattgtaa actgttgtcg caagggaaga agacagtgac 120 ggtaccttgt gagaaagtca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 180 acaagcgttg tccggattta ctgggtgtaa agggcgcgta ggcggactgt caagtcagtc 240 gtgaaatacc ggggcttaac cccggggctg cgattgaaac tgacagcctt gagtatcgga 300 gaggaaagcg gaattcctag tgtagcggtg aaatgcgtag atattaggag gaacaccagt 360 ggcgaaggcg gctttctgga cgacaactga cgctgaggcg cgaaagtatg gggagcaaac 420 aggattagat accccggtag tcc 443

Claims

하기 (1) 내지 (28) 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물
(1) 서열 번호: 22 또는 46에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(2) 서열 번호: 21 또는 54에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(3) 서열 번호: 18 또는 55에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(4) 서열 번호: 9 또는 30에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(5) 서열 번호: 19 또는 33에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(6) 서열 번호: 17 또는 34에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(7) 서열 번호: 3 또는 43에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(8) 서열 번호: 6 또는 53에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(9) 서열 번호: 7 또는 35에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(10) 서열 번호: 2 또는 39에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(11) 서열 번호: 25 또는 41에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(12) 서열 번호: 23 또는 50에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(13) 서열 번호: 24 또는 45에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(14) 서열 번호: 26 또는 48에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(15) 서열 번호: 8 또는 40에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(16) 서열 번호: 4 또는 37에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(17) 서열 번호: 13 또는 38에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(18) 서열 번호: 16 또는 56에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(19) 서열 번호: 14 또는 57에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(20) 서열 번호: 27 또는 36에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(21) 서열 번호: 12 또는 42에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(22) 서열 번호: 15, 31 또는 49에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(23) 서열 번호: 5, 52 또는 51에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(24) 서열 번호: 20 또는 44에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(25) 서열 번호: 1 또는 32에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(26) 서열 번호: 11 또는 29에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(27) 서열 번호: 10 또는 47에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(28) 서열 번호: 28 또는 422에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA.
제1항에 있어서, 상기 패칼리박테리움 프라우스니치이가, 상기 (1) 내지 (28)에 기재된 28의 DNA를 갖는 패칼리박테리움 프라우스니치이인, 조성물.
하기 (1) 내지 (3) 중 적어도 1의 DNA를 갖는 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:
(1) 서열 번호: 22 또는 46에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(2) 서열 번호: 21 또는 54에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA,
(3) 서열 번호: 18 또는 55에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열을 포함하는 DNA.
제3항에 있어서, 상기 패칼리박테리움 프라우스니치이가, 상기 (1) 내지 (3)에 기재된 3의 DNA를 갖는 패칼리박테리움 프라우스니치이인, 조성물.
하기 DNA군에서 선택되는 적어도 1의 DNA를 갖는, 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:
서열 번호: 58 내지 207에 관한 뉴클레오티드 서열을 각각 포함하는 150의 DNA군(단, 서열 번호: N에 관한 뉴클레오티드 서열은, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열이다. N은 58 내지 207 중 어느 것이다).
하기 DNA군에서 선택되는 적어도 1의 DNA를 갖는, 패칼리박테리움 프라우스니치이, 당해 미생물의 성분, 또는 당해 미생물의 배양물을 유효 성분으로서 함유하는, 뇌 기능의 저하의 예방 혹은 치료, 또는 뇌 기능의 유지 혹은 개선을 하기 위한 조성물:
서열 번호: 208 내지 421에 관한 뉴클레오티드 서열을 각각 포함하는 214의 DNA군(단, 서열 번호: N에 관한 뉴클레오티드 서열은, 서열 번호: N에 기재된 뉴클레오티드 서열이 코딩하는 아미노산 서열에 대하여, 40％ 이상의 상동성을 갖는 아미노산 서열을 코딩하는 뉴클레오티드 서열이다. N은 208 내지 421 중 어느 것이다).
제1항 내지 제6항 중 어느 한 항에 있어서, 상기 뇌 기능이 인지 기능인, 조성물.
제1항 내지 제6항 중 어느 한 항에 있어서, 식품 조성물인, 조성물.
제1항 내지 제6항 중 어느 한 항에 있어서, 의약 조성물인, 조성물.
수탁 번호 NITE BP-03169로 특정되는 미생물.
수탁 번호 NITE BP-03196으로 특정되는 미생물.
경도 인지 장애의 평가 방법이며,
(1) 피검자 분변 중의 미생물을 정량하는 공정,
(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 미생물을 정량하여 얻어지는 대응값과 비교하는 공정, 및
(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한
상기 미생물이, 패칼리박테리움속에 속하는 미생물, 아나에로스티페스속에 속하는 미생물, CAG-41속에 속하는 미생물, 바르네시엘라속에 속하는 미생물, 및 루미노코커스속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.
경도 인지 장애의 평가 방법이며,
(1) 피검자 분변 중의 미생물을 정량하는 공정,
(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 미생물을 정량하여 얻어지는 대응값과 비교하는 공정, 및
(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 높은 경우에, 상기 피검자는 경도 인지 장애의 상태라고 판정하는 공정을 포함하며, 또한 상기 미생물이 프레보텔라속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.
알츠하이머병의 평가 방법이며,
(1) 피검자 분변 중의 미생물을 정량하는 공정,
(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 미생물을 정량하여 얻어지는 대응값과 비교하는 공정, 및
(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 낮은 경우에, 상기 피검자는 알츠하이머병을 이환하고 있다고 판정하는 공정을 포함하며, 또한 상기 미생물이, 블라우티아속에 속하는 미생물, 푸시카테니박터속에 속하는 미생물, 루미노코커스속에 속하는 미생물, 및 유박테리움속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.
알츠하이머병의 평가 방법이며,
(1) 피검자 분변 중의 미생물을 정량하는 공정,
(2) 공정 (1)에서 정량하여 얻어진 값을, 정상인 분변 중의 상기 미생물을 정량하여 얻어지는 대응값과 비교하는 공정, 및
(3) 공정 (2)에 있어서의 비교의 결과, 피검자 분변 중의 상기 정량값이, 상기 대응값보다도 높은 경우에, 상기 피검자는 알츠하이머병을 이환하고 있다고 판정하는 공정을 포함하며, 또한 상기 미생물이, 파라박테로이데스속에 속하는 미생물로 이루어지는 군에서 선택되는 적어도 1의 미생물인, 방법.