CN116785387A - 一种中药组合物及其在制备呼吸道疾病药物中的用途 - Google Patents
一种中药组合物及其在制备呼吸道疾病药物中的用途 Download PDFInfo
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- CN116785387A CN116785387A CN202310853279.7A CN202310853279A CN116785387A CN 116785387 A CN116785387 A CN 116785387A CN 202310853279 A CN202310853279 A CN 202310853279A CN 116785387 A CN116785387 A CN 116785387A
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Abstract
本发明属于中药领域，具体涉及一种中药组合物及其在制备呼吸道疾病药物中的用途，本发明所述中药组合物主要由茯苓、桔梗、蜜麻黄、制半夏、酒地龙、蜜百部、桑白皮、浙贝母、黄芪、辛夷、陈皮、杏仁、生甘草、蝉衣、鱼腥草、蜜炙紫苑、炙冬花、葶苈子、白芥子、百药煎组成，能够有效缓解呼吸道疾病引起的发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难等病症，对于治疗呼吸道疾病疗效显著。
Description
技术领域
本发明属于中药领域，具体涉及一种中药组合物及其在制备呼吸道疾病药物中的用途。
背景技术
呼吸道疾病是临床上一种常见病、多发病，包括急性上呼吸道感染、肺炎、支气管哮喘、支气管扩张症、肺结核、慢性支气管炎、慢性阻塞性肺疾病、肺脓肿等。
支气管炎是指气管、支气管黏膜及其周围组织的慢性非特异性炎症。支气管炎主要原因为病毒和细菌的反复感染形成了支气管的慢性非特异性炎症。当气温下降、呼吸道小血管痉挛缺血、防御功能下降等利于致病；烟雾粉尘、污染大气等慢性刺激也可发病；吸烟使支气管痉挛、黏膜变异、纤毛运动降低、黏液分泌增多有利感染，过敏因素也有一定关系。
慢性阻塞性肺疾病是一种具有气流阻塞特征的慢性支气管炎和(或)肺气肿，可进一步发展为肺心病和呼吸衰竭的常见慢性疾病，常见症状有慢性咳嗽、咳痰、气短或呼吸困难、喘息和胸闷等。
肺炎指肺泡、远端气道和肺间质的感染性炎症，主要由细菌、病毒等病原体引起的肺部感染，常有发热、咳嗽、咳痰等典型症状，其中以细菌性和病毒性肺炎最为常见，患者常有发烧、咳嗽、呼吸困难等典型症状，病毒性肺炎可通过空气传播。
现有技术的中药组合物对于治疗呼吸道疾病的效果欠佳。
发明内容
克服现有技术的不足，本发明提供了一种中药组合物以及在制备呼吸道疾病药物中的用途，克服了现有技术中中药组合物治疗呼吸道疾病效果欠佳的缺陷，提供了一种主要由茯苓、桔梗、蜜麻黄、制半夏、酒地龙、蜜百部、桑白皮、浙贝母、黄芪、辛夷、陈皮、杏仁、生甘草、蝉衣、鱼腥草、蜜炙紫苑、炙冬花、葶苈子、白芥子、百药煎组成的中药组合物，用于治疗呼吸道疾病。
具体而言，本发明的技术方案如下：
本发明提供了一种用于治疗呼吸道疾病的中药组合物，所述中药组合物以重量份计算为：
茯苓10～15份、桔梗7～15份、蜜麻黄4～8份、制半夏3～9份、酒地龙4～8份、蜜百部3～8份、桑白皮4～10份、浙贝母4～9份、黄芪9～30份、辛夷3～10份、陈皮7～10份、杏仁0.5～2份、生甘草2～10份、蝉衣3～7份、鱼腥草7～20份、蜜炙紫苑4～10份、炙冬花4～9份、葶苈子5～12份、白芥子3～9份、百药煎4～8份；
在一个较优的实施例中，所述中药组合物以重量份计算为：
茯苓12份、桔梗10份、蜜麻黄6份、制半夏6份、酒地龙6份、蜜百部6份、桑白皮6份、浙贝母6份、黄芪15份、辛夷6份、陈皮9份、杏仁1份、生甘草5份、蝉衣6份、鱼腥草10份、蜜炙紫苑6份、炙冬花6份、葶苈子10份、白芥子6份、百药煎6份。
上述中药组合物的制备方法，采用水煎煮法制备。
进一步的，所述的中药组合物可直接或加入药学上可接受的辅料后制备成临床上可接受的制剂。所述的临床上可接受的制剂为口服固体制剂或液体制剂。
本发明的第二个目的在于提供上述中药组合物或者采用上述方法制备得到的中药组合物在制备治疗呼吸道疾病的药物中的用途。
进一步的，所述呼吸道疾病包括上呼吸道感染和下呼吸道感染。
所述下呼吸道感染为气管炎、支气管炎、肺炎、慢性阻塞性肺疾病、肺气肿。
本发明的第三个目的在于：所述中药组合物可以缓解呼吸道疾病引起的发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难的症状。
与现有技术相比，本发明的有益效果在于：
本发明所述的中药组合物主要由茯苓、桔梗、蜜麻黄、制半夏、酒地龙、蜜百部、桑白皮、浙贝母、黄芪、辛夷、陈皮、杏仁、生甘草、蝉衣、鱼腥草、蜜炙紫苑、炙冬花、葶苈子、白芥子、百药煎组成，疏风清热，解表化痰，可有效缓解发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难等病症，具有较好的治疗呼吸道疾病的功效。
临床使用效果证明，经本发明中药组合物治疗后的患者，其发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难、咽干咽痒等症状明显好转，中医证候评价效果显著，治疗急性上呼吸道感染的有效率达到93.33％，治疗支气管炎的有效率达到95.0％，治疗慢性阻塞性肺疾病的有效率达到91.67％。
附图说明
图1急性上呼吸道感染患者诊断病历
图2支气管炎患者诊断病历
图3慢性肺阻塞疾病患者诊断病历
图4咳嗽症状患者诊断病历
图5肺部感染患者诊断病历
图6慢性支气管炎伴肺气肿患者诊断病历
具体实施方式
为了使本发明的目的、技术方案更加清楚明白，以下结合实施例，对本发明做进一步的说明，但是本发明的保护范围并不限于这些实施例，实施例仅用于解释本发明。本领域技术人员应该理解的是，凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
一、中药组合物
实施例1
茯苓12g、桔梗10g、蜜麻黄6g、制半夏6g、酒地龙6g、蜜百部6g、桑白皮6g、浙贝母6g、黄芪15g、辛夷6g、陈皮9g、杏仁1g、生甘草5g、蝉衣6g、鱼腥草10g、蜜炙紫苑6g、炙冬花6g、葶苈子10g、白芥子6g、百药煎6g，洗净、处理后，加水煎煮，浓缩至100～400ml，即得。
实施例2
茯苓10g、桔梗7g、蜜麻黄4g、制半夏3g、酒地龙4g、蜜百部3g、桑白皮4g、浙贝母4g、黄芪9g、辛夷3g、陈皮7g、杏仁0.5g、生甘草2g、蝉衣3g、鱼腥草7g、蜜炙紫苑4g、炙冬花4g、葶苈子5g、白芥子3g、百药煎4g，洗净、处理后，加水煎煮，浓缩至100～400ml，即得。
实施例3
茯苓15g、桔梗15g、蜜麻黄8g、制半夏9g、酒地龙8g、蜜百部8g、桑白皮10g、浙贝母9g、黄芪30g、辛夷10g、陈皮10g、杏仁2g、生甘草10g、蝉衣7g、鱼腥草20g、蜜炙紫苑10g、炙冬花9g、葶苈子12g、白芥子9g、百药煎8g，洗净、处理后，加水煎煮，浓缩至100～400ml，即得。
实施例4
茯苓12g、桔梗10g、蜜麻黄6g、制半夏6g、酒地龙6g、蜜百部6g、桑白皮6g、浙贝母6g、黄芪15g、辛夷6g、陈皮9g、杏仁1g、生甘草5g、蝉衣6g、鱼腥草10g、蜜炙紫苑6g、炙冬花6g、葶苈子10g、白芥子6g、百药煎6g，洗净、处理后，加水煎煮，过滤，浓缩至相对密度为1.35～1.38的清膏，加入适量糊精、蔗糖，混匀，制成颗粒，干燥，即得。
实施例5
茯苓12g、桔梗10g、蜜麻黄6g、制半夏6g、酒地龙6g、蜜百部6g、桑白皮6g、浙贝母6g、黄芪15g、辛夷6g、陈皮9g、杏仁1g、生甘草5g、蝉衣6g、鱼腥草10g、蜜炙紫苑6g、炙冬花6g、葶苈子10g、白芥子6g、百药煎6g，洗净、处理后，加水煎煮，过滤，浓缩至相对密度为1.35～1.38的清膏，加入适量糊精、蔗糖、硬脂酸镁，混匀，制软材，制粒，干燥、整粒，加入适量羧甲淀粉钠，压片，即得。
对比实施例1
葶苈子15g，桑白皮10g，鱼腥草30g，丹参15g，银花20g，连翘20g，茯苓10g，芦根30g，陈皮10g，洗净、处理后，加水煎煮，浓缩至100～400ml，即得。
二、临床效果验证
本发明中药组合物源于本医院临床经验方，具有较好的临床使用效果。
(一)本发明中药组合物对上呼吸道感染病例的临床分析
1资料与方法
1.1一般资料
选择2022年11月-2023年3月收治的30例急性上呼吸道感染患者，随机分为对照组(15例)与观察组(15例)。对照组患者年龄41～70岁，平均(62.4±5.9)岁；男9例，女6例；病程1～7d。观察组患者年龄45～69岁，平均(61.5±5.1)岁；男8例，女7例；病程～7d。两组患者各项基本资料对比均差异无统计学意义，P＞0.05。
1.2纳入标准：
(1)符合西医《实用内科学》与中医《中医内科学》中的相关诊断标准者；
(2)依据病史、流行情况及炎症症状、体征等检查，同时经过X线检查，临床诊断为上呼吸道感染者；
(3)与风热证辨证标准符合，主证为：鼻塞流涕、咽痛、发热等，次证：口渴、咳嗽、头痛等；
(4)发病后未使用过治疗本病的其他药物者等。
(5)患者签署知情同意书，研究经院内医学伦理委员会批准。
1.3排除标准：
(1)伴肺炎、急性支气管炎、肺结核者；
(2)怀疑或确有乙醇、药物滥用病史者；
(3)机体其他组织器官发生感染，且末得到控制者等。
2方法
2.1治疗方法
对照组治疗方案：给予对比实施例1所得汤剂，每日两剂，早晚服用，连续治疗5d。
观察组治疗方案：给予实施例1所得汤剂，每日两剂，早晚服用，连续治疗5d。
2.2观察指标
中医证候评价判定治疗效果
显效：体温恢复正常，鼻塞、喷嚏、咳嗽等症状体征消失；
有效：体温恢复正常，鼻塞、喷嚏、咳嗽等症状体征明显改善，少许鼻分泌物；
无效：体温未降低反而升高，鼻塞、喷嚏、咳嗽等症状体征无改善或加重，鼻分泌物增多。
总有效率(％)＝显效率(％)+有效率(％)。
3结果
表1上呼吸道感染临床病例治疗效果
| 组别 | 例数 | 显效(例) | 有效(例) | 无效(例) | 总有效率(％) |
| 对照组 | 15 | 10 | 4 | 1 | 93.33 |
| 观察组 | 15 | 5 | 6 | 4 | 73.33 |
病例统计显示，本发明中药组合物能够有效治疗急性上呼吸道感染以及缓解其引起的相关病症，有效率达到93.33％。
(一)本发明中药组合物对支气管炎病例的临床分析
1资料与方法
1.1一般资料
选择2022年11月-2023年3月收治的80例急性上呼吸道感染患者，随机分为对照组(40例)与观察组(40例)。对照组患者年龄35～72岁，平均(59.2±6.2)岁；男21例，女19例。观察组患者年龄31～68岁，平均(58.4±5.7)岁；男20例，女20例。两组患者各项基本资料对比均差异无统计学意义，P＞0.05。
1.2纳入标准：
(1)满足支气管炎的诊断标准；
(2)近1个月未进行抗菌、抗病毒、免疫调节等相关治疗；
(3)患者签署知情同意书，研究经院内医学伦理委员会批准。
1.3排除标准：
(1)先天性心、肝、肾、肺等病变者；
(2)哮喘、肺不张、肺结核、支原体肺炎、肺肿瘤等其他呼吸系统病变；
(3)自身免疫系统、内分泌系统病变；
(4)精神异常，不配合治疗者。
2方法
2.1治疗方法
对照组治疗方案：给予对比实施例1所得汤剂，每日两剂，早晚服用，连续治疗7d。
观察组治疗方案：给予实施例1所得汤剂，每日两剂，早晚服用，连续治疗7d。
2.2观察指标
中医证候评价判定治疗效果
显效：症状体征完全消退，X线复常，一般情况恢复；
有效：咳喘症状改善，一般情况恢复，X线结果减轻；
无效：未达到上述标准。
总有效率(％)＝显效率(％)+有效率(％)。
3结果
表2支气管炎临床病例治疗效果
| 组别 | 例数 | 显效(例) | 有效(例) | 无效(例) | 总有效率(％) |
| 对照组 | 40 | 32 | 6 | 2 | 95.00 |
| 观察组 | 40 | 22 | 11 | 7 | 82.50 |
病例统计显示，本发明中药组合物能够有效治疗支气管炎以及缓解其引起的相关病症，有效率达到95.0％。
(一)本发明中药组合物对慢性阻塞性肺病临床病例的统计分析
1资料与方法
1.1一般资料
选择2022年10月-2023年3月收治的24例慢性阻塞性肺病患者，随机分为对照组(12例)与观察组(12例)。对照组患者年龄46～89岁，平均(72.3.2±4.1)岁；男8例，女4例。观察组患者年龄45～91岁，平均(71.1±4.5)岁；男7例，女5例。两组患者各项基本资料对比均差异无统计学意义，P＞0.05。
1.2纳入标准：
(1)符合中华医学会呼吸病学分会制定《慢性阻塞性肺疾病诊治指南》诊断标准
(2)患者签署知情同意书，研究经院内医学伦理委员会批准。
1.3排除标准：
(1)先天性心、肝、肾、肺等病变者，严重痴呆患者；
(3)自身免疫系统、内分泌系统病变；
(4)精神异常，不配合治疗者。
2方法
2.1治疗方法
对照组治疗方案：给予对比实施例1所得汤剂，每日两剂，早晚服用，连续治疗10d。
观察组治疗方案：给予实施例1所得汤剂，每日两剂，早晚服用，连续治疗10d。
2.2观察指标
中医证候评价判定治疗效果
显效：慢性咳嗽、咳痰、气短及呼吸困难病症消退，X线复常；
有效：慢性咳嗽、咳痰、气短及呼吸困难病症改善，X线结果减轻；
无效：未达到上述标准。
总有效率(％)＝显效率(％)+有效率(％)。
3结果
表2支气管炎临床病例治疗效果
| 组别 | 例数 | 显效(例) | 有效(例) | 无效(例) | 总有效率(％) |
| 对照组 | 12 | 7 | 4 | 1 | 91.67 |
| 观察组 | 12 | 4 | 5 | 3 | 75.00 |
病例统计显示，本发明中药组合物能够有效治疗慢性阻塞性肺疾病以及缓解其引起的相关病症，有效率达到91.67％。
需要说明的是，发明中药组合物对于其他呼吸道疾病的临床效果也同样显著，在此不一一呈现，此外，本发明中药组合物还能够缓解由于呼吸道疾病引起的发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难等症状。
Claims (9)
1.一种用于治疗呼吸道疾病的中药组合物，其特征在于，所述中药组合物主要由茯苓、桔梗、蜜麻黄、制半夏、酒地龙、蜜百部、桑白皮、浙贝母、黄芪、辛夷、陈皮、杏仁、生甘草、蝉衣、鱼腥草、蜜炙紫苑、炙冬花、葶苈子、白芥子、百药煎组成。
2.根据权利要求1所述的中药组合物，其特征在于，所述中药组合物以重量份计算为：
茯苓10~15份、桔梗7~15份、蜜麻黄4~8份、制半夏3~9份、酒地龙4~8份、蜜百部3~8份、桑白皮4~10份、浙贝母4~9份、黄芪9~30份、辛夷3~10份、陈皮7~10份、杏仁0.5~2份、生甘草2~10份、蝉衣3~7份、鱼腥草7~20份、蜜炙紫苑4~10份、炙冬花4~9份、葶苈子5~12份、白芥子3~9份、百药煎4~8份；
优选的，所述中药组合物以重量份计算为：
茯苓12份、桔梗10份、蜜麻黄6份、制半夏6份、酒地龙6份、蜜百部6份、桑白皮6份、浙贝母6份、黄芪15份、辛夷6份、陈皮9份、杏仁1份、生甘草5份、蝉衣6份、鱼腥草10份、蜜炙紫苑6份、炙冬花6份、葶苈子10份、白芥子6份、百药煎6份。
3.一种制备权利要求1或2所述中药组合物的方法，其特征在于，采用水煎煮法制备。
4.根据权利要求1或2所述的中药组合物，其特征在于，所述的中药组合物可直接或加入药学上可接受的辅料后制备成临床上可接受的制剂。
5.根据权利要求4所述的中药组合物，其特征在于，所述的临床上可接受的制剂为口服固体制剂或液体制剂。
6.权利要求1或2所述的中药组合物或者采用权利要求3所述的方法制备得到的中药组合物在制备治疗呼吸道疾病的药物中的用途。
7.根据权利要求6所述的用途，其特征在于，所述呼吸道疾病包括上呼吸道感染和下呼吸道感染。
8.根据权利要求7所述的用途，其特征在于，所述下呼吸道感染为气管炎、支气管炎、肺炎、慢性阻塞性肺疾病、肺气肿。
9.根据权利要求6所述的用途，其特征在于，所述中药组合物可以缓解呼吸道疾病引起的发热、咳嗽、咳痰、流涕、咽痛、咽喉红肿、呼吸困难的症状。
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| CN117100833B (zh) * | 2023-10-07 | 2024-06-07 | 青苗医疗有限公司 | 一种调理肠道菌群的中药组合物及其制备方法和应用 |
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