CN116785242A - 重构脂质体安那霉素的方法以及应用 - Google Patents

重构脂质体安那霉素的方法以及应用 Download PDF

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Publication number
CN116785242A
CN116785242A CN202310738252.3A CN202310738252A CN116785242A CN 116785242 A CN116785242 A CN 116785242A CN 202310738252 A CN202310738252 A CN 202310738252A CN 116785242 A CN116785242 A CN 116785242A
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CN
China
Prior art keywords
anamycin
liposomal
saline
vial
bag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310738252.3A
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English (en)
Chinese (zh)
Inventor
D·皮克
W·普里布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molekulin Biotechnology
University of Texas System
Original Assignee
Molekulin Biotechnology
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molekulin Biotechnology, University of Texas System filed Critical Molekulin Biotechnology
Publication of CN116785242A publication Critical patent/CN116785242A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CN202310738252.3A 2019-06-28 2020-06-25 重构脂质体安那霉素的方法以及应用 Pending CN116785242A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962868190P 2019-06-28 2019-06-28
US62/868,190 2019-06-28
PCT/US2020/039621 WO2020264161A1 (en) 2019-06-28 2020-06-25 Method of reconstituting liposomal annamycin
CN202080048890.7A CN114728101B (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080048890.7A Division CN114728101B (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法

Publications (1)

Publication Number Publication Date
CN116785242A true CN116785242A (zh) 2023-09-22

Family

ID=74061076

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310738252.3A Pending CN116785242A (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法以及应用
CN202080048890.7A Active CN114728101B (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080048890.7A Active CN114728101B (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法

Country Status (15)

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US (2) US12257262B2 (enExample)
EP (1) EP3990041B1 (enExample)
JP (1) JP7830131B2 (enExample)
KR (1) KR20220027941A (enExample)
CN (2) CN116785242A (enExample)
AU (2) AU2020302784A1 (enExample)
BR (1) BR112021026480A2 (enExample)
CA (1) CA3144443A1 (enExample)
ES (1) ES3049663T3 (enExample)
IL (1) IL289433B2 (enExample)
MX (1) MX2021015667A (enExample)
PL (1) PL3990041T3 (enExample)
SG (1) SG11202113005SA (enExample)
TW (2) TW202500161A (enExample)
WO (1) WO2020264161A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020264161A1 (en) 2019-06-28 2020-12-30 Donald Picker Method of reconstituting liposomal annamycin
EP3989978B1 (en) 2019-06-28 2025-12-17 Board of Regents, The University of Texas System Preparation of preliposomal annamycin lyophilizate
AU2020386092A1 (en) * 2019-11-21 2022-06-16 Board Of Regents, The University Of Texas System Lung targeted anticancer therapies with liposomal annamycin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US20040057989A1 (en) * 1999-10-29 2004-03-25 Board Of Regents, The University Of Texas System Method of cancer treatment
US20140308339A1 (en) * 2003-02-14 2014-10-16 Children's Hospital And Research Center At Oakland Lipophilic drug delivery vehicle and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927571A (en) 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
US4863739A (en) 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US20130045937A1 (en) * 2010-03-10 2013-02-21 Cempra Pharmaceuticals, Inc. Parenteral formulations of macrolide antibiotics
PT4241849T (pt) * 2011-10-14 2024-10-30 Hoffmann La Roche Utilizações do inibidor da dimerização de her2 pertuzumab e artigo de fabrico que inclui o mesmo
KR102284689B1 (ko) * 2011-10-21 2021-08-02 셀라토 파마슈티칼즈, 인코포레이티드 동결건조된 리포좀
US8926994B2 (en) 2011-12-07 2015-01-06 The Methodist Hospital Research Institute Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
WO2016040882A1 (en) 2014-09-13 2016-03-17 Novartis Ag Combination therapies of egfr inhibitors
KR20170066546A (ko) 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
CN107569508A (zh) * 2016-07-05 2018-01-12 江苏竞诺择生物医药科技有限公司 一种治疗造血系统增殖性疾病的药用组合物
AU2017324718B2 (en) * 2016-09-09 2022-09-29 Irisys, Inc. Lipsomal anticancer compositions
WO2019023873A1 (zh) * 2017-07-31 2019-02-07 江苏竞诺择生物医药科技有限公司 一种用于治疗造血系统增殖性疾病的纳米脂质微粒组合物及药用组合物
UA129837C2 (uk) 2018-09-04 2025-08-20 Мінерва Ньюросаєнсиз, Інк. Способи застосування феноксипропіламінової сполуки для лікування болю
WO2020264161A1 (en) 2019-06-28 2020-12-30 Donald Picker Method of reconstituting liposomal annamycin
EP3989978B1 (en) 2019-06-28 2025-12-17 Board of Regents, The University of Texas System Preparation of preliposomal annamycin lyophilizate
AU2020386092A1 (en) 2019-11-21 2022-06-16 Board Of Regents, The University Of Texas System Lung targeted anticancer therapies with liposomal annamycin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US20040057989A1 (en) * 1999-10-29 2004-03-25 Board Of Regents, The University Of Texas System Method of cancer treatment
US20140308339A1 (en) * 2003-02-14 2014-10-16 Children's Hospital And Research Center At Oakland Lipophilic drug delivery vehicle and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YIYU ZOU ET AL.: "Lyophilized preliposomal formulation of the non-cross-resistant anthracycline annamycin: effect of surfactant on liposome formation, stability and size", CANCER CHEMOTHER PHARMACOL, vol. 39, 31 December 1996 (1996-12-31), pages 103 - 108, XP000939147, DOI: 10.1007/s002800050544 *

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Publication number Publication date
SG11202113005SA (en) 2021-12-30
ES3049663T3 (en) 2025-12-17
IL289433A (en) 2022-02-01
TW202114704A (zh) 2021-04-16
IL289433B2 (en) 2026-05-01
BR112021026480A2 (pt) 2022-02-08
AU2020302784A1 (en) 2022-01-20
US20220105116A1 (en) 2022-04-07
MX2021015667A (es) 2022-04-18
US11980634B2 (en) 2024-05-14
IL289433B1 (en) 2026-01-01
CN114728101A (zh) 2022-07-08
WO2020264161A1 (en) 2020-12-30
TW202500161A (zh) 2025-01-01
US12257262B2 (en) 2025-03-25
PL3990041T3 (pl) 2026-02-23
CN114728101B (zh) 2023-07-14
JP2023523872A (ja) 2023-06-08
EP3990041A1 (en) 2022-05-04
AU2024203593B2 (en) 2025-08-14
EP3990041A4 (en) 2023-07-12
CA3144443A1 (en) 2020-12-30
EP3990041B1 (en) 2025-08-06
JP7830131B2 (ja) 2026-03-16
TWI857086B (zh) 2024-10-01
AU2024203593A1 (en) 2024-07-11
US20240024345A1 (en) 2024-01-25
KR20220027941A (ko) 2022-03-08

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