CN116782907A - 消毒剂 - Google Patents
消毒剂 Download PDFInfo
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- CN116782907A CN116782907A CN202180089311.8A CN202180089311A CN116782907A CN 116782907 A CN116782907 A CN 116782907A CN 202180089311 A CN202180089311 A CN 202180089311A CN 116782907 A CN116782907 A CN 116782907A
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- Prior art keywords
- disinfectant
- weight
- benzalkonium
- present
- phenoxyethanol
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 47
- 239000003795 chemical substances by application Substances 0.000 title description 3
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960001716 benzalkonium Drugs 0.000 claims abstract description 18
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 15
- 150000001282 organosilanes Chemical class 0.000 claims abstract description 7
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 12
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 12
- 241000191967 Staphylococcus aureus Species 0.000 claims description 12
- 229960005323 phenoxyethanol Drugs 0.000 claims description 12
- 241000588724 Escherichia coli Species 0.000 claims description 11
- 241000700605 Viruses Species 0.000 claims description 9
- WSFMFXQNYPNYGG-UHFFFAOYSA-M dimethyl-octadecyl-(3-trimethoxysilylpropyl)azanium;chloride Chemical class [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](OC)(OC)OC WSFMFXQNYPNYGG-UHFFFAOYSA-M 0.000 claims description 8
- 241000194033 Enterococcus Species 0.000 claims description 6
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 241000711573 Coronaviridae Species 0.000 claims description 4
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- 150000003839 salts Chemical group 0.000 claims description 4
- 208000025721 COVID-19 Diseases 0.000 claims description 2
- 241001678559 COVID-19 virus Species 0.000 claims description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 2
- 241000186781 Listeria Species 0.000 claims description 2
- 241001263478 Norovirus Species 0.000 claims description 2
- 241000315672 SARS coronavirus Species 0.000 claims description 2
- 241000607142 Salmonella Species 0.000 claims description 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims description 2
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 241000712461 unidentified influenza virus Species 0.000 claims description 2
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 35
- 238000009472 formulation Methods 0.000 description 34
- 239000000047 product Substances 0.000 description 12
- 230000009467 reduction Effects 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 238000006386 neutralization reaction Methods 0.000 description 5
- 244000052769 pathogen Species 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000003253 viricidal effect Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- GVUBZTSOFTYNQE-UHFFFAOYSA-M dimethyl-octadecyl-(3-trihydroxysilylpropyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCC[Si](O)(O)O GVUBZTSOFTYNQE-UHFFFAOYSA-M 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000012137 tryptone Substances 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 230000007402 cytotoxic response Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 239000000787 lecithin Substances 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
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- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000005789 organism growth Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000001967 plate count agar Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
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Abstract
许多已知消毒剂的问题是它们不能在皮肤上提供很长时间的保护。本发明的目的是解决这个问题。本发明涉及有机硅烷和苯甲烃铵在制备消毒剂中的用途，所述消毒剂包括0.25%‑0.35%重量有机硅烷和0.09%‑0.11%重量苯甲烃铵。所述消毒剂在人体皮肤上可提供有效的消毒保护时间≥24 h。
Description
技术领域
本发明涉及一种例如用于手部的长效人体皮肤消毒剂。
背景技术
众所周知，将消毒液应用于人体皮肤上以杀死病菌(例如细菌和病毒)。许多已知消毒剂的问题是，它们仅在短时间段内有效，并且必须频繁地重新使用，否则如果使用它们的人接触病菌所在的表面，则相对而言不会受到感染。
本发明的目的
本发明的优选实施方案的目的是至少在某种程度上解决上述问题。虽然这适用于优选的实施方案，但不应被视为对更广泛表达的权利要求的限制。本发明的最广泛形式的目的仅仅是为公众提供有用的选择。
定义
术语“包括”或“具有”如果并且当在本文件中用于特征的组合时，不应被视为排除组合中未提及的附加特征的选项。
发明内容
根据一个方面，本发明包括有机硅烷和苯甲烃铵(Benzalkonium)在制备消毒剂中的用途，所述消毒剂包括：
a)0.25％-0.35％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基铵盐；和
b)0.09％-0.11％重量的苯甲烃铵；
其中所述消毒剂在人体皮肤上提供有效的消毒保护时间≥24h。
术语“有效的消毒保护”意指消毒剂杀死人体皮肤上≥99％(优选地≥99.99％)的病菌。
任选地，所述消毒剂包括：
a)0.25％-0.35％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵；和
b)0.09％-0.11％重量的苯甲烃铵。
任选地，所述消毒剂包括：
a)0.3％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵；和
b)0.1％重量的苯甲烃铵。
任选地，所述苯甲烃铵是盐的形式。
任选地，所述盐形式包括苯扎氯铵。
任选地，所述消毒保护是针对冠状病毒的。
任选地，所述消毒保护是针对SARS-CoV-1和/或SARS-CoV-2(例如CoVid-19引起的冠状病毒)。
任选地，所述消毒剂包括苯氧基乙醇，所述苯氧基乙醇在消毒剂中起防腐剂的作用。
任选地，所述苯氧基乙醇以0.7％-1.3％重量存在于所述消毒剂中。
任选地，所述苯氧基乙醇以0.8％-1.2％重量存在于所述消毒剂中。
任选地，所述苯氧基乙醇以0.9％-1.1％重量存在于所述消毒剂中。
任选地，所述苯氧基乙醇以1％重量存在于消毒剂中。
任选地，所述消毒剂包括乙基己基甘油，所述乙基己基甘油在消毒剂中起防腐剂的作用。
任选地，所述乙基己基甘油以0.07％-0.13％重量存在于所述消毒剂中。
任选地，所述乙基己基甘油以0.08％-0.12％重量存在于所述消毒剂中。
任选地，所述乙基己基甘油以0.09％-0.11％重量存在于所述消毒剂中。
任选地，所述乙基己基甘油以0.1％重量存在于所述消毒剂中。
任选地，所述消毒保护是针对希拉肠球菌、铜绿假单胞菌、金黄色葡萄球菌、大肠杆菌、诺如病毒、念珠菌、MRSA、沙门氏菌、李斯特菌、流感病毒和MHV1病毒中的一种或多种。
任选地，所述消毒保护是针对希拉肠球菌、铜绿假单胞菌、金黄色葡萄球菌和大肠杆菌中的一种或多种。
任选地，所述消毒剂在人手部上可提供有效的消毒保护时间≥24h。
任选地，所述消毒剂作为液体大量应用于皮肤，以提供有效的消毒保护。例如，提供0.5mL-1mL的量并且优选地0.75mL，对于平均身材的成年男性的两只手来说是足够的。
具体实施方式
制备了三种水性发泡消毒剂制剂，其具有下表所示的组成。
制剂A
制剂B
制剂C
在每种情况下，制剂如下制备：
步骤1：
将所有的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵溶解在足量的水中，使其构成总重量为最终产品的6％重量的预混合物。
步骤2
将所有苯扎氯铵溶解或悬浮在足量的水中，以提供总重量为最终产品的0.2％重量的预混合物溶液或悬浮液。
步骤3
在单独的混合容器中，加入总重量为最终产品的90.8％重量的水。
步骤4
将每种预混合物(如步骤1和2所述)分别加入到步骤3的水中，并且混合。
步骤5
将所有苯氧基乙醇和乙基己基甘油加入到混合容器的内容物中，并且混合。
步骤6
将所有甘油加入到混合容器中的组分中，并且混合。
步骤7
充分搅拌(持续≥10分钟)，直到所有成分被均质化。
消毒剂性能测试
对每种制剂进行测试，以观察它在杀死病菌方面的效果。这包括根据熟知的欧洲测试标准EN 13727评估杀菌活性的定量悬浮测试。还通过ASTM 1053的表面载体技术测试了制剂的杀病毒活性。此外，对每种制剂进行测试，以确定其在被应用于人体皮肤(手部)之后24小时的有效性。测试如下进行。
步骤1(培养成长)
在试验中选择并且评估了两种测试生物体：
·金黄色葡萄球菌NZRM 147(ATCC 6538)
·大肠杆菌NZRM 2577(ATCC 8739)
使用过夜培养板为生物体制备培养悬浮液。从每个板收获培养生长物，并且接种到10mL胰蛋白胨大豆肉汤(TSB)中，以获得109cfu/mL的生物体计数。
步骤2(化学灭活)
中和剂和稀释剂的组合用于实现有效的中和系统。特别地，含有0.5％卵磷脂和4％吐温20的胰蛋白胨大豆肉汤(TLT)被用作中和溶液。将“即用型”(RTU)浓度的洗手液制剂以1:1000的比率稀释(在10mL TLT中的10μL，体积于稀释比率与经处理的体外皮肤2cm2相同)。然后，10mL稀释的制剂被单独加入，以使细胞水平足以使测试生物体浓度在可计数的范围内。在TLT存在的情况下，测试产品的抗微生物性质被中和，以便回收任何存活的生物体。在测试产品存在的情况下，测试生物体的回收率不低于从接种物对照回收的回收率的70％。
步骤3
在生物安全柜中，两个2cm2的合成皮肤样本各自用10μL的RTU浓度的测试产品进行预处理。每对皮肤样本一起摩擦以分配测试产品，并且在HEPA层流空气下干燥。制剂在样本上保留持续足够长的时间，以证明每种测试产品的残余功效。在每个时间点对所有测试产品(包括参考产品)和水对照进行重复测试。
步骤4–(水对照-基线对照)
合成皮肤样本也以与测试产品相同的方式用无菌水进行预处理，并且在测试产品旁边的相同时间点进行测试。
步骤5
在不同的时间点，用109cfu/mL浓度的10μL的培养悬浮液接种每个经处理的皮肤样本，并且用无菌1μL环均匀分布。在将皮肤样本转移到中和肉汤(TLT)中之前，允许5分钟的暴露时间。
步骤6
将接种的中和肉汤混合并且连续稀释，以帮助确定剩余的活细菌的数量。
步骤7
按照步骤5和6，以与测试产品相同的方式测试水对照。
步骤8
使用0.1％蛋白胨连续地稀释用于测试产品和水对照的中和的溶液，并且使用标准板计数琼脂将每种稀释液以一式两份进行铺板。
步骤9
将板在35℃±1℃孵育持续48小时。
测试给出了如下详述的结果。
结果
用于评价杀菌活性的定量悬液测试
方法：EN13727
CFU＝菌落形成单位
NV是在验证悬浮液中每mL的细胞数。
A、B和C是在接触时间结束时，在实验条件对照(A)、中和剂对照(B)和方法验证(C)中存活细胞的数量
A、B和C优选地应当为≥Nv值的50％。
作为总结，(TMD 110，EN13727)，制剂A和B在1分钟接触时间显示出针对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和希拉肠球菌大于6个对数减少。制剂C在1分钟接触时间显示出针对大肠杆菌、铜绿假单胞菌和希拉肠球菌大于6个对数减少，和针对金黄色葡萄球菌大于5个对数减少。在接触1分钟之后，所有三种制剂导致微生物减少>99.99％。
通过载体方法的杀病毒测试的结果
方法：ASTM E1053
注意：
病毒的存在以4的X+的形式即X+/4呈现：
X+–存在病毒(+)的孔的数量(X)
4–接种的孔的总数。
实例：在3+/4结果的情况下，这表明总共4个孔中的3个显示阳性病毒响应。
在每个响应中不存在病毒被记录为“0”
细胞毒性响应被记录为“C”
计算的病毒滴度＝106.77TCID50/0.1mL(6.77log10)
细胞对照-具有健康细胞单层的4个孔
*The Reed&Muench LD50方法用于确定病毒滴度终点。
为了总结关于细胞毒性和中和作用的结果(TMCV 006，ASTM E1053)，制剂A和B通过在室温下暴露1分钟时间段后病毒浓度达到3.44个对数减少显示出针对MHV1的杀病毒功效。制剂C也通过在室温下暴露1分钟时间段后病毒浓度达到3.10个对数减少显示出针对MHV1的杀病毒功效。这表明每种制剂在1分钟接触时间后导致病毒计数减少>99.9％，其中制剂A和B显示出比制剂C稍微更好的结果。
结果
手消毒剂产品的24小时残余抗微生物研究方法：上述定制的体外研究方案
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残余功效结果的总结(制剂A)
残余功效结果的总结(制剂B)
残余功效结果的总结(制剂C)
作为总结，制剂B(在RTU体积下)显示了针对金黄色葡萄球菌NZRM 147和大肠杆菌NZRM 2577的残余功效，其中在整个24小时时间段内(在5分钟、30分钟、1小时、2小时、4小时、6小时和24小时)对数减少在2.27和>6.57之间。相比之下，制剂A和C针对任一种细菌菌株都没有表现出有效的残余功效(任一种生物体的最大对数减少在任何时间点都不超过0.2)。
制剂B在24小时后显示出针对金黄色葡萄球菌和大肠杆菌的残余生物杀灭活性减少(分别为4.93个对数和2.46个对数)。这意味着金黄色葡萄球菌和大肠杆菌的数量分别减少了>99.99％和>99％，即使在应用制剂B之后24小时暴露于任一种生物体。相反，制剂A在24小时之后表现出针对金黄色葡萄球菌的低对数减少(0.02)，此外还表现出针对大肠杆菌的负对数减少(-0.10)，表明生物体的生长。类似地，制剂C在24小时之后导致针对金黄色葡萄球菌(-0.04)和大肠杆菌(-0.12)的负对数减少，表明生物体生长。
这是重要的，因为它表明，即使在应用该制剂后已经过了很长的时间之后，制剂B针对合成皮肤上的微生物仍表现出残余功效。这被认为与制剂B中苯甲烃铵和有机硅烷成分所提供的协同相互作用有关。
其他形式的苯甲烃铵
虽然根据本发明的优选的制剂利用苯扎氯铵，但是在其他实施方案中，这可以被其他形式的苯甲烃铵替代，例如苯甲烃铵游离碱或一种或多种替代的苯甲烃铵盐(例如苯扎溴铵、苯甲烃铵糖精酸盐和安赛蜜苯甲烃铵)。在每种情况下，重量将被调整以提供或多或少的等效功能。
其他有机硅烷
类似地，尽管本发明的优选的形式利用3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵，但在其他实施方案中，这可以被其他有机硅烷例如3-(三羟基甲硅烷基)丙基二甲基十八烷基氯化铵(CAS 199111-50-7)和n,n-二甲基-n-[3-(三甲氧基甲硅烷基)丙基]-1-十四烷基氯化铵(CAS 41591-87-1)中的一种或多种取代。在每种情况下，重量将被调整以提供或多或少的等效功能。
防腐剂、湿润剂和表面活性剂
此外，根据本发明的制剂可以使用替代制剂A、B和C的防腐剂、湿润剂和/或表面活性剂材料的替代品，适当地调整重量以提供或多或少的等效功能。这些的实例如下：
就公开内容而言，本文件据此公开了本文提及的每个项目、特征或步骤与本文公开的任何其他项目、特征或步骤中的一个或多个的组合，在每种情况下，不管这种组合是否被要求保护。
虽然已经通过实例的方式描述了本发明的一些优选的实施方案，但是应当理解，在不脱离所附权利要求的范围的情况下，可以进行修改和改进。
Claims (22)
1.有机硅烷和苯甲烃铵在制备消毒剂中的用途，所述消毒剂包括：
a)0.25％-0.35％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基铵盐；和
b)0.09％-0.11％重量的苯甲烃铵；
其中所述消毒剂在人体皮肤上可提供有效的消毒保护时间≥24h。
2.根据权利要求1所述的用途，其中所述消毒剂包括：
a)0.25％-0.35％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵；和
b)0.09％-0.11％重量的苯甲烃铵。
3.根据权利要求1所述的用途，其中所述消毒剂包括：
a)0.3％重量的3-(三甲氧基甲硅烷基)丙基二甲基十八烷基氯化铵；和
b)0.1％重量的苯甲烃铵。
4.根据权利要求1-3中任一项所述的用途，其中所述苯甲烃铵为盐形式。
5.根据权利要求4所述的用途，其中所述盐形式包括苯扎氯铵。
6.根据权利要求1-5中任一项所述的用途，其中所述消毒保护是针对冠状病毒的。
7.根据权利要求1-6中任一项所述的用途，其中所述消毒保护可以针对SARS-CoV-1和/或SARS-CoV-2(例如CoVid-19引起的冠状病毒)。
8.根据权利要求1-7中任一项所述的用途，所述消毒剂包括苯氧基乙醇，所述苯氧基乙醇在所述消毒剂中起防腐剂的作用。
9.根据权利要求8所述的用途，其中所述苯氧基乙醇以0.7％-1.3％重量存在于所述消毒剂中。
10.根据权利要求8所述的用途，其中所述苯氧基乙醇以0.8％-1.2％重量存在于所述消毒剂中。
11.根据权利要求8所述的用途，其中所述苯氧基乙醇以0.9％-1.1％重量存在于所述消毒剂中。
12.根据权利要求8所述的用途，其中所述苯氧基乙醇以1％重量存在于所述消毒剂中。
13.根据权利要求1-12中任一项所述的用途，所述消毒剂包括乙基己基甘油，所述乙基己基甘油在所述消毒剂中起防腐剂的作用。
14.根据权利要求13所述的用途，其中所述乙基己基甘油以0.07％-0.13％重量存在于所述消毒剂中。
15.根据权利要求13所述的用途，其中所述乙基己基甘油以0.08％-0.12％重量存在于所述消毒剂中。
16.根据权利要求13所述的用途，其中所述乙基己基甘油以0.09％-0.11％重量存在于所述消毒剂中。
17.根据权利要求13所述的用途，其中所述乙基己基甘油以0.1％重量存在于所述消毒剂中。
18.根据权利要求1-17中任一项所述的用途，其中所述消毒保护是针对希拉肠球菌、铜绿假单胞菌、金黄色葡萄球菌、大肠杆菌、诺如病毒、念珠菌、MRSA、沙门氏菌、李斯特菌、流感病毒和MHV1病毒中的一种或多种。
19.根据权利要求1-18中任一项所述的用途，其中所述消毒保护是针对希拉肠球菌、铜绿假单胞菌、金黄色葡萄球菌和大肠杆菌中的一种或多种。
20.根据权利要求1-19中任一项所述的用途，其中所述消毒剂在人手部上可提供有效的消毒保护时间≥24h。
21.一种根据权利要求1-20中任一项所述的用途制备的消毒剂。
22.一种消毒剂，基本上如下：
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