CN116745320A - 诊断或治疗健康状况或优化car-t细胞疗法的治疗功效的方法 - Google Patents

诊断或治疗健康状况或优化car-t细胞疗法的治疗功效的方法 Download PDF

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Publication number
CN116745320A
CN116745320A CN202180088499.4A CN202180088499A CN116745320A CN 116745320 A CN116745320 A CN 116745320A CN 202180088499 A CN202180088499 A CN 202180088499A CN 116745320 A CN116745320 A CN 116745320A
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China
Prior art keywords
car
cell
individual
expression level
cell therapy
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Pending
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CN202180088499.4A
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English (en)
Chinese (zh)
Inventor
R·迈茨纳
C·L·麦考尔
C·芒特
M·芒赫-迪赛罗斯
D·B·米克罗斯
M·弗兰克
Y·莱库纳姆
A·A·艾莉莎黛
B·索德
D·M·库尔茨
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of CN116745320A publication Critical patent/CN116745320A/zh
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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CN202180088499.4A 2020-11-04 2021-11-04 诊断或治疗健康状况或优化car-t细胞疗法的治疗功效的方法 Pending CN116745320A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063109611P 2020-11-04 2020-11-04
US63/109,611 2020-11-04
PCT/US2021/058102 WO2022098903A1 (en) 2020-11-04 2021-11-04 Methods for diagnosing or treating health conditions or optimizing therapeutic efficacy of car-t cells therapies

Publications (1)

Publication Number Publication Date
CN116745320A true CN116745320A (zh) 2023-09-12

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CN202180088499.4A Pending CN116745320A (zh) 2020-11-04 2021-11-04 诊断或治疗健康状况或优化car-t细胞疗法的治疗功效的方法

Country Status (11)

Country Link
US (1) US20250281532A1 (https=)
EP (1) EP4240771A4 (https=)
JP (1) JP2023548509A (https=)
KR (1) KR20230091177A (https=)
CN (1) CN116745320A (https=)
AU (1) AU2021374937A1 (https=)
CA (1) CA3196359A1 (https=)
GB (1) GB2616162A (https=)
IL (1) IL302450A (https=)
MX (1) MX2023004929A (https=)
WO (1) WO2022098903A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116516007B (zh) * 2023-04-18 2024-01-19 华中科技大学同济医学院附属协和医院 Cd19表达的检测方法
WO2024227096A1 (en) * 2023-04-28 2024-10-31 Sana Biotechnology, Inc. Anti-cd19 car t cells for treating b-cell malignancies and autoimmune diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103175966B (zh) * 2012-10-31 2015-09-09 北京大学人民医院 急性b淋巴细胞白血病启动细胞表型分类试剂盒及其应用
KR20170068504A (ko) * 2014-10-08 2017-06-19 노파르티스 아게 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도
WO2018081830A1 (en) * 2016-10-31 2018-05-03 Oregon Health & Science University Combinations of agents to treat hematological malignancies
EP3788369A1 (en) * 2018-05-01 2021-03-10 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome

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Publication number Publication date
EP4240771A1 (en) 2023-09-13
AU2021374937A1 (en) 2023-06-15
EP4240771A4 (en) 2025-01-08
GB202308212D0 (en) 2023-07-19
AU2021374937A9 (en) 2024-10-24
KR20230091177A (ko) 2023-06-22
CA3196359A1 (en) 2022-05-12
WO2022098903A1 (en) 2022-05-12
JP2023548509A (ja) 2023-11-17
GB2616162A (en) 2023-08-30
IL302450A (en) 2023-06-01
MX2023004929A (es) 2023-05-17
US20250281532A1 (en) 2025-09-11

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