CN116726132A - Wen Yangfa-based traditional Chinese medicine composition for treating non-lactation-stage mastitis tumors and preparation method and application thereof - Google Patents
Wen Yangfa-based traditional Chinese medicine composition for treating non-lactation-stage mastitis tumors and preparation method and application thereof Download PDFInfo
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- CN116726132A CN116726132A CN202310655179.3A CN202310655179A CN116726132A CN 116726132 A CN116726132 A CN 116726132A CN 202310655179 A CN202310655179 A CN 202310655179A CN 116726132 A CN116726132 A CN 116726132A
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Abstract
The application provides a Wen Yangfa-based traditional Chinese medicine composition for treating non-lactation-period mastitis tumors, and a preparation method and application thereof, and the Wen Yangfa-based traditional Chinese medicine composition is matched with traditional Chinese medicine formula collapse therapy on the basis of oral administration of traditional Chinese medicines, so that the beneficial effects of shortening the treatment course, reducing external treatment adverse reactions, improving the patient acceptance, facilitating the use of patients and reducing the economic pressure of the patients can be achieved.
Description
Technical Field
The application relates to the field of traditional Chinese medicines, in particular to a Wen Yangfa-based traditional Chinese medicine composition for treating non-lactation-period mastitis tumors, and a preparation method and application thereof.
Background
In recent years, the incidence of female non-lactation mastitis rises year by year, the disease is complex, the disease is easy to relapse, certain difficulty exists in clinical treatment, the non-lactation mastitis has certain correlation with autoimmune abnormality, when the organism immunity is excessive, the disease of a patient can be promoted, and the disease can cause a plurality of adverse effects on the physiology and the psychology of the patient. The conventional medicines such as corticosteroid and immunosuppressant are not good in treatment effect, and patients are easy to generate drug resistance and the cure rate is reduced along with the extension of the administration time. The traditional Chinese medicine for treating non-lactation mastitis is called as 'acne acute mastitis', takes liver depression and stasis heat as main causes, and adopts the main treatment method to treat the non-lactation mastitis by using medicines with the effects of soothing liver, resolving masses, nourishing blood and clearing fire, and the bupleurum liver-fire clearing decoction is used as a representative formula. In addition, the combination of external treatment of traditional Chinese medicine has become an inevitable trend of treating non-lactation mastitis, the external treatment aspect of inflammatory lump stage is mainly the application treatment at present, and different medicaments are adopted for treatment according to yang swelling or yin swelling.
In the non-lactation period, mastitis, i.e. acne type acute mastitis, the doctor who takes clear idea as guidance in the past considers that the acne type acute mastitis patients often have acute disease appearance, reddish complexion, obvious increase of the affected breasts, red swelling and pain, and one pattern of yang-heat, and the patients are in excess, i.e. excessive pathogenic qi and healthy qi are still present, so the patients are treated by a method of nourishing serum fire, soothing liver and resolving masses. The representative formula is bupleurum liver-clearing soup: the bupleurum root and the baikal skullcap root in the prescription have the effects of dispelling and relieving the heat of the stasis of the shaoyang, the burdock, the gardenia, the weeping forsythia and the radix trichosanthis are used together to obtain the blood-replenishing effect of the four-ingredient decoction and strengthen the blood-activating effect, and can prevent the cold and excessive drugs, and the liquorice is used for harmonizing the drugs to slow down the rapid drugs, so that the prescription has the effects of soothing the liver and clearing the fire. However, in clinical practice, many doctors pay attention to that excessive use of heat-clearing and detoxicating drugs can cause breast agglomeration to become stiff or become chronic or subacute persistent mastitis during treatment of mastitis by the qingtong method. And even if the treatment has a certain effect, the treatment period is often longer, and patients cannot adhere to long-term administration, so that the treatment fails.
The traditional Chinese medicine application method has small application area, can not treat the non-lactation mastitis patients with large tumor, and has certain stimulation effect on skin due to the application method which is often treated by using the medicines with relatively large pungency, and sometimes causes local skin redness and swelling, itching, burning, pain, even blisters and other adverse reactions.
Disclosure of Invention
The application aims at overcoming the defects of the prior art and provides a Wen Yangfa-based traditional Chinese medicine composition for treating non-lactation-period mastitis tumors, and a preparation method and application thereof.
The technical scheme adopted by the application is as follows:
a Wen Yangfa-based traditional Chinese medicine composition for treating non-nursing-stage mastitis tumors, comprising: the collapse formula composition is an external prescription and is matched with infrared irradiation. The collapse formula composition comprises the following raw materials in parts by weight:
1-12 parts of kusnezoff monkshood root, 1-6 parts of arisaema tuber, 1-12 parts of dried ginger, 1-6 parts of white paeony root and 1-3 parts of cassia bark.
Further, the collapse formula comprises the following raw materials in parts by weight:
1-9 parts of kusnezoff monkshood root, 1-3 parts of arisaema tuber, 1-9 parts of dried ginger, 1-3 parts of white paeony root and 1-1.5 parts of cassia bark.
Further, the collapse formula comprises the following raw materials in parts by weight: 9 parts of kusnezoff monkshood root, 3 parts of arisaema tuber, 9 parts of dried ginger, 3 parts of white peony root and 1.5 parts of cinnamon.
Further, the Chinese medicinal composition also comprises an oral Chinese medicinal composition, wherein the oral Chinese medicinal composition is yang-harmonizing soup.
Further, the yang-harmonizing soup is composed of the following raw materials in parts by weight:
4 parts of prepared rehmannia root, 5 parts of spina gleditsiae, 5 parts of semen vaccariae, 5 parts of antler slices, 4 parts of white mustard seed, 2 parts of roasted ephedra herb, 3 parts of baked ginger charcoal, 2 parts of liquorice and 4 parts of loofah sponge.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the formula amount of kusnezoff monkshood root, arisaema tuber, dried ginger, white paeony root and cassia bark;
decocting radix Aconiti Kusnezoffii, rhizoma arisaematis, rhizoma Zingiberis, radix Paeoniae alba, and cortex Cinnamomi with water, and concentrating to obtain Chinese medicinal composition.
The application relates to application of a traditional Chinese medicine composition in preparation of medicines for preventing or treating breast diseases, wherein the breast diseases are breast inflammatory tumors.
According to the application, wen Yangzhi method and traditional Chinese medicine collapse method are creatively combined, and the final treatment effects of dispelling cold, eliminating phlegm and turbidity, removing blood stasis and calming inflammation are achieved through grasping pathogenesis of cold coagulation and blood stasis and through external application of five traditional Chinese medicines of kusnezoff monkshood root, arisaema tuber, dried ginger, white paeony root and cassia bark. The application shortens the course of treatment (can be cured in 2-3 months) by combining the yang warming method with the treatment of the traditional Chinese medicine formula collapse method, reduces adverse reactions, improves the acceptance, is convenient to use and reduces economic pressure.
Drawings
FIG. 1 is an ultrasound view of the first diagnosis of case 1;
FIG. 2 is an ultrasound image of case 1 two diagnosis;
FIG. 3 is an ultrasound image of case 1 three diagnosis;
FIG. 4 is an ultrasound view of the first diagnosis of case 2;
FIG. 5 is an ultrasound image of case 2 diagnosis two;
FIG. 6 is an ultrasound image of case 2 three diagnosis;
Detailed Description
The inventor of the patent combines the clinical experience and scientific research results for many years, reasonably proposes the innovative concept of 'acne acute mastitis belongs to mammary yin syndrome', successfully verifies the acne acute mastitis by years of clinical practice, and finely distinguishes the acne acute mastitis as 'yang deficiency and cold accumulation syndrome', and specifically states as follows.
The non-lactation mastitis comprises chronic refractory diseases of the breast such as granulomatous lobular mastitis, plasmacytoid mastitis and the like, the disease condition is complex, the disease course is prolonged and is not healed, and no exact and efficient treatment mode exists in Western medicine clinic. The inventor of the patent finds that the initial mass of the disease is mostly different in skin color, flat collapse, hard, pain-free or fever-free in the department of study; after being stimulated by external force, emotion, diet and the like, the tumor can suddenly increase, skin color or red or purple, the self-sense local skin temperature rises, the pain is accompanied by pricking and even chicken pecking pain, and the pain is broken and purulent when not being treated in time, however, the whole body of the patient is not clear and sensible heat, but is warm, the tongue is pale, the tongue coating is white and greasy, and the pulse is deep and slow or smooth; the skin of the lump is dull in color, hard in texture, long in time of bursting, difficult to converge and heavy in fistula and sinus. It follows that clinical manifestations of non-lactating mastitis are typical of yin syndromes. According to the disease characteristics and the disease process, the disease is identified as the syndrome of yang deficiency and cold congealing, which is similar to yin carbuncle in nature; in the suppuration stage, qi movement is depressed and turned into heat, and steamed meat is decomposed into phlegm to be abscess, so that yang symptoms such as red, swelling, heat, pain and the like are displayed on the surface, and the symptoms of red, light and moist people and qi and blood are out of the way, namely pus-expelling and toxin-expelling are accompanied symptoms.
In conclusion, the inventor inherits and breaks through the concept of the full-life type internal blowing acute mastitis as yin gangrene, considers that the acne acute mastitis belongs to yin syndrome, can be classified as yang deficiency and cold coagulation, and can be distinguished and treated according to the Wen Yangfa concept of warming yang, resolving coagulation, activating blood and relieving pain. Wen Yangfa the recipe is a pathological product of warming and resolving the interior and expelling cold, warming and resolving yang-qi to supplement the remaining pathogenic factors and deficient yang, and simultaneously warming and resolving the interior and resolving the pathogenic cold to achieve the effect of warming and resolving the interior and resolving the exterior. The recipe is mainly represented by yang-harmonizing decoction.
Based on the yang warming treatment method, the patent creatively proposes to give a collapse method treatment to the non-lactation-period mammitis tumor, shortens the course of the disease, reduces the side effect and obtains better clinical curative effect.
The collapse of Chinese medicine belongs to the external treatment method of Chinese medicine, and is recorded in Yu Zhen Shui (Yu Zhen Shui) and is also wet. "Zhi Hai" is characterized by "soaking, soaking". "collapse" refers to applying a cotton cloth containing a medicinal liquid to an affected part, and "stain" refers to immersing the affected part in the medicinal liquid, and is called a collapse method because the two methods are often used together. The method has the advantages of external treatment of internal diseases, exterior and interior penetration, activating collaterals, dispelling cold, promoting blood circulation, relieving pain, and directly reaching focus, has good treatment effect, simple operation method, safety, no side effect, and is widely used clinically.
The main effects of traditional Chinese medicine collapse are as follows: firstly, the activated substances in the traditional Chinese medicinal materials pass through skin tissues to reach focus, so that the blood brain barrier is avoided, and the traditional Chinese medicinal preparation has the characteristics of quick response, no toxic or side effect, stable curative effect and the like; the traditional Chinese medicine composition is used for relieving or alleviating numbness and weakness of various limbs and has the effects of preventing and treating diseases and strengthening body by applying treatment methods such as warming and dredging channels and collaterals, detumescence and resolving masses, dispelling dampness and dispelling cold and the like; thirdly, the therapy can be flexibly used clinically, and the required treatment mouth can be achieved by selecting different traditional Chinese medicines for compatibility.
The main components of the collapse formula of the application are kusnezoff monkshood root, arisaema tuber, dried ginger, white paeony root and cassia bark.
Radix aconiti kusnezoffii): pungent and bitter in flavor, warm in nature, and toxic. It enters heart, liver, kidney and spleen meridians. Has the main effects of dispelling wind and removing dampness, warming meridians and relieving pain.
Arisaema with the following formula: bitter and pungent in flavor, warm in nature and toxic. It enters lung, liver and spleen meridians. Has the main effects of dispelling wind, relieving spasm, resolving phlegm and resolving masses.
Dried ginger: pungent in flavor and warm in nature. It enters spleen, stomach, heart and lung meridians. Has the main effects of warming middle energizer to dispel cold, restoring yang and dredging collaterals.
Cinnamon: pungent and sweet in flavor, and big in heat. It enters kidney, spleen, heart and liver meridians. Has the main effects of invigorating primordial yang, warming spleen and stomach, removing accumulated cold and promoting blood circulation.
White peony root: bitter and sour in flavor and slightly cold in nature. Enter liver and spleen meridians. Has the main effects of nourishing blood, regulating menstruation, astringing yin, stopping sweating, softening liver, relieving pain and suppressing liver yang.
The theory of meridians states that: the nipple of women belongs to liver and breast belongs to stomach, and the nipple belongs to the liver meridian of foot jueyin, the nipple belongs to the liver meridian of hand three yin meridian, and the prescription accords with the meridian tropism of breast disease.
The radix aconiti kusnezoffii dosage in the prescription is the largest, and the externally applied medicine can dispel wind and remove dampness, activate dead muscles and remove bone pain; the theory of treating yin-gangrene in surgical syndrome book is that "treating method, not ephedra herb, not cinnamon, ginger, can not break its film theory, not cinnamon, ginger, can not resolve its congealing cold; the symptoms of the disease are that the symptoms of the disease are removed with the symptoms of the disease, and the symptoms of the disease are removed with the symptoms of the disease. So it can help kusnezoff monkshood root to dispel cold, resolve congealing, warm blood and promote blood generation. All three herbs are pungent and fragrant in nature and can dispel cold and yin toxicity, and return yang qi. The arisaema tuber has the functions of eliminating dampness and phlegm and eliminating caking; radix paeoniae alba relieves pain, promotes blood circulation, dissipates blood, eliminates carbuncle and swelling; the medicines are combined to have the effects of warming yang, resolving coagulation, activating blood and relieving pain. The whole prescription is warm except the property of white peony root, and the other medicines are stir-fried or stewed for enhancing the efficacy of restoring yang and expelling cold, and the medicines are used together by heating power to run the breast directly to the affected part. Just coping with the manifestation of cold stiff lump of non-lactation mastitis, the pathogenesis of cold congealing phlegm and blood stasis is cut off, so that the cold of the mastitis is dispersed, phlegm turbidity is eliminated, blood stasis is eliminated, inflammation is flattened, namely the collapse formula also accords with Wen Yangzhi method.
The specific technical scheme of the application is as follows: a collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 1-12 parts of kusnezoff monkshood root, 1-6 parts of arisaema tuber, 1-12 parts of dried ginger, 1-6 parts of white paeony root and 1-3 parts of cassia bark, and the 5 raw materials are decocted with water and concentrated, when the medicine is used, a patient takes a supine position, dips the medicine liquid with sterilized gauze to wet compress a breast lump area on the affected side, and simultaneously carries out physiotherapy and heat preservation by assisting an infrared lamp, each time in the morning and evening, preferably 1 hour each time, and 7 consecutive days are a treatment course.
The following detailed description of the technical solutions of the present application will be given by specific embodiments, and it should be understood that the specific features of the embodiments of the present application are detailed descriptions of the technical solutions of the present application, and not limiting the technical solutions of the present application, and the technical features of the embodiments of the present application may be combined with each other without conflict.
Example 1
A collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 90g of kusnezoff monkshood root, 30g of arisaema tuber, 90g of dried ginger, 30g of white paeony root and 15g of cassia bark, and decocting the 5 raw materials with water and concentrating to 100ml to obtain a patch of the traditional Chinese medicine. When in use, the patient takes the supine position, dips the liquid medicine with the sterilized gauze to wet compress the affected side breast lump region, and simultaneously assists the infrared lamp for physiotherapy and heat preservation, and each time is 1 hour in the morning and the evening, and 7 consecutive days are a treatment course.
Example 2
A collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 120g of kusnezoff monkshood root, 30g of arisaema tuber, 120g of dried ginger, 30g of white paeony root and 15g of cassia bark, and decocting the 5 raw materials with water and concentrating to 100ml to obtain a patch of the traditional Chinese medicine. When in use, the patient takes the supine position, dips the liquid medicine with the sterilized gauze to wet compress the affected side breast lump region, and simultaneously assists the infrared lamp for physiotherapy and heat preservation, and each time is 1 hour in the morning and the evening, and 7 consecutive days are a treatment course.
Example 3
A collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 60g of kusnezoff monkshood root, 30g of arisaema tuber, 60g of dried ginger, 30g of white paeony root and 15g of cassia bark, and decocting the 5 raw materials with water and concentrating to 100ml to obtain a patch of the traditional Chinese medicine. When in use, the patient takes the supine position, dips the liquid medicine with the sterilized gauze to wet compress the affected side breast lump region, and simultaneously assists the infrared lamp for physiotherapy and heat preservation, and each time is 1 hour in the morning and the evening, and 7 consecutive days are a treatment course.
Example 4
A collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 90g of kusnezoff monkshood root, 30g of arisaema tuber, 90g of dried ginger, 60g of white paeony root and 15g of cassia bark, and decocting the 5 raw materials with water and concentrating to 100ml to obtain a patch of the traditional Chinese medicine. When in use, the patient takes the supine position, dips the liquid medicine with the sterilized gauze to wet compress the affected side breast lump region, and simultaneously assists the infrared lamp for physiotherapy and heat preservation, and each time is 1 hour in the morning and the evening, and 7 consecutive days are a treatment course.
Example 5
A collapse formulation for treating non-lactating mastitis lump based on Wen Yangfa is combined with infrared irradiation. The raw material medicaments comprise the following components in part by weight: 90g of kusnezoff monkshood root, 60g of arisaema tuber, 90g of dried ginger, 30g of white paeony root and 30g of cassia bark, and decocting the 5 raw materials with water and concentrating to 100ml to obtain a patch of the traditional Chinese medicine. When in use, the patient takes the supine position, dips the liquid medicine with the sterilized gauze to wet compress the affected side breast lump region, and simultaneously assists the infrared lamp for physiotherapy and heat preservation, and each time is 1 hour in the morning and the evening, and 7 consecutive days are a treatment course.
Clinical verification
Case 1:
first diagnosis at 2021, 03, 10: guo Mou women, 34 years old, staff, complaints: the red swelling pain of right milk repeatedly attacks for 1 half year. The symptoms are as follows: pain in right milk, nipple discharge, no obvious aversion to cold, fever and other discomfort, hypodynamia, listlessness, poor appetite, insomnia Shang An and convenient adjustment. Physical examination: the size of the lump at the mammary gland position on the outer side of the right milk is about 12cm multiplied by 10cm, and the skin is not red and hot and has tenderness. Pale red tongue with white and greasy coating and wiry and slippery pulse. As shown in fig. 1, b ultrasonic: the diffuse hypoechoic area of right milk, BI-RADS 3 class, considers chronic suppurative mastitis. Western diagnosis: non-lactation mastitis. Diagnosis of traditional Chinese medicine: acne-like acute mastitis, with the symptoms of yang deficiency and congealing cold, phlegm-stasis and blood stasis. For warming yang, dispelling cold, promoting blood circulation, and removing obstruction in collaterals. Wen Yangfa yang and decoction are added for treating, and the specific prescription is as follows: 12g of prepared rehmannia root, 15g of spina gleditsiae, 15g of semen vaccariae, 15g of antler slices, 12g of white mustard seed, 6g of roasted ephedra, 9g of baked ginger charcoal, 6g of liquorice and 12g of loofah sponge, and 7 patches of the prepared dried ginger charcoal are decocted to 200ml with water for 2 times a day, and 100ml of the prepared dried ginger charcoal is taken after each meal; meanwhile, the specific prescription of the collapse prescription 7 in the embodiment 1 is as follows: radix aconiti kusnezoffii 90g, arisaema tuber 30g, dried ginger 90g, white peony root 30g and cinnamon 15g. The 5 raw materials are decocted with water and concentrated to 100ml, when in use, a patient takes a supine position, dips the liquid medicine with sterile gauze to wet compress the affected side breast lump region, and simultaneously assists an infrared lamp to perform physiotherapy and heat preservation, and each time is 1 hour in the morning and evening, and 7 consecutive days are a treatment course.
Two diagnoses at 2021, 3 and 17 days: the patient had contracted from the anterior right breast mass, behind the right areola and a mass of about 3 x 2cm, with the mass in the middle, the border being less clear, the movement being less optimal, and the pain being compressed (+). A pale tongue with a thin and red coating and a wiry pulse. As shown in fig. 2, b ultrasonic: the right breast can see a plurality of mixed echo clusters, the larger size is about 2.9 cm (behind areola), the shape is elliptical, the long axis is parallel to the skin, the edge is smooth, and the inner part can see fine low echo spots, so that the effect on surrounding tissues is avoided. Adding Weiyang and decoction, adding 12g of loofah sponge, 12g of lily and 30g of reed rhizome, and decocting 7 pieces together; the application method of the patent is 7 pieces of the Chinese patent, and the application method is the same as before.
Three diagnoses at 2021, 3, 24 and three days: the patient was significantly reduced from the tumor. Checking: the right breast was palpable to a 2.5 x 1.0cm tumor on the outside, as shown in fig. 3, ultrasound b: several hypoechoic areas are visible in the right breast, with a larger range of about 2.3 x 0.4cm (10 points direction), distributed along the catheter, with no apparent strong echogenic focus and liquid dark areas.
The patient can be cured after the patient is continuously treated for 1 month by taking the formula, the physical examination and the double breast do not touch the obvious tumor, the B ultrasonic prompts the double breast not to see the obvious hypoechoic area, and the double breast hyperplasia is changed.
Case 2:
first diagnosis at 11/4/2021: xie Mou women, 32 years old, free occupation, complaint: the red and swollen left milk is repeatedly broken and is repeatedly used for 1 month. The symptoms are as follows: pain in left milk, nipple discharge, obvious aversion to cold, fever and other discomforts, hypodynamia, listlessness, poor appetite, poor sleep and convenient adjustment. Physical examination: the size of the 6-7 point tumor on the inner side of the left breast is about 5cm multiplied by 2cm, the skin is broken, the skin color is dark, and the pain is caused. Pale red tongue with white and greasy coating and wiry and slippery pulse. As shown in fig. 4, b ultrasonic: left breast 6-7 point gland echo disorder, uneven distribution, visible several mixed echo areas, larger range about 4.1 x 0.7, irregular shape, distributed along the catheter, blurred edge, local connection with nipple, mutual communication, internal detectable and fine light spots, no echo change at the back. Western diagnosis: non-lactation mastitis. Diagnosis of traditional Chinese medicine: acne-like acute mastitis, with the symptoms of yang deficiency and congealing cold, phlegm-stasis and blood stasis. For warming yang, dispelling cold, promoting blood circulation, and removing obstruction in collaterals. The following specific prescription is provided for the collapse prescription 7 in the embodiment 1 Wen Yangfa: radix aconiti kusnezoffii 90g, arisaema tuber 30g, dried ginger 90g, white peony root 30g and cinnamon 15g. The 5 raw materials are decocted with water and concentrated to 100ml, when in use, a patient takes a supine position, dips the liquid medicine with sterile gauze to wet compress the affected side breast lump region, and simultaneously assists an infrared lamp to perform physiotherapy and heat preservation, and each time is 1 hour in the morning and evening, and 7 consecutive days are a treatment course.
Two diagnoses at 11/2021: the patient is continuously collapsed and treated for 1 week, the left breast lump is contracted and softened from front, the broken mouth is purulent and closed from front, the lower quadrant of the left breast lump can be a lump of about 3 x 1.5cm, the quality is soft, the boundary is not clear, the activity is poor, and the pain is high. A pale tongue with a thin and red coating and a wiry pulse. As shown in fig. 5, b ultrasonic: left external lower gland echo disorder, uneven distribution, visible several hypoechoic areas, mutual communication, about 3.4 x 1.1cm in a larger range, irregular morphology, distribution along a catheter, blurring edge, local connection with skin, mutual communication, internal detectable and fine light spots, unchanged back echo, thickening of surrounding tissues and structural disorder. The Chinese medicine is treated by the collapse method again, 7 pieces of Chinese medicine are added, and the collapse method is the same as the previous method.
Three diagnoses at 2021, 11, 18 and three days: the patient is treated by the collapse method once again, the tumor is not obviously reduced from the previous one, and the texture is obviously softened. Checking: the left internal quadrant, the areola side can reach 3.5 x 1.0cm tumor, as shown in fig. 6, b-ultrasound: left milk local gland echo disorder, uneven distribution, visible scattering in a plurality of hypoechoic areas, about 3.3 x 0.8cm (the inner side of areola), irregular morphology, distribution along a catheter, blurred edges, local connection under the skin, mutual communication, internal detectable and fine light spots, unchanged back echo, thickened surrounding tissues and disordered structure. The patient needs to take the Chinese medicine orally, so the Chinese medicine oral administration is combined with the patent to continue the treatment of the collapse stain prescription.
The oral administration is continued for 2 months, the curing is completed, the left breast is examined, the healing scar of the crumbling mouth is visible, the local red swelling and pain are avoided, and the left breast does not touch the obvious tumor. B ultrasonic prompting: double milk hyperplasia-like changes.
Case 3:
first diagnosis in 2023, 03, 13: lv Mou women, 26 years old, banking staff, complaints: the left breast incision is repeated for 5 months. Before 5 months, the left breast was treated by local enlarged excision and fasciosis of the left breast due to the swelling of the lower quadrant of the left breast after the left breast was traumatized, with the symptoms of hard and red swelling and pain. Postoperative general pathology prompt: granulomatous lobular mastitis. Physical examination: the double breasts are symmetrical, the nipple on the two sides is slightly concave, an incision with the length of about 3cm is visible in the lower part of the left breast, a small amount of liquid seepage is accompanied, and the double breasts are free from red swelling and pain and pressure pain locally. And (5) auxiliary detection: double-emulsion B ultrasonic wave: the left milk multiple hypoechoic area (larger size about 2.7 x 1.1 cm), BI-RADS 3 class, considers inflammation. Western diagnosis: non-lactation mastitis. Diagnosis of traditional Chinese medicine: acne-like acute mastitis, with the symptoms of yang deficiency and congealing cold, phlegm-stasis and blood stasis. For warming yang, dispelling cold, promoting blood circulation, and removing obstruction in collaterals. Wen Yangfa collapse prescription 7 is prepared from the following specific prescription drugs: radix aconiti kusnezoffii 90g, arisaema tuber 30g, dried ginger 90g, white peony root 30g and cinnamon 15g. The 5 raw materials are decocted with water and concentrated to 100ml, when in use, a patient takes a supine position, dips the liquid medicine with sterile gauze to wet compress the affected side breast lump region, and simultaneously assists an infrared lamp to perform physiotherapy and heat preservation, and each time is 1 hour in the morning and evening, and 7 consecutive days are a treatment course.
2023, 3, 20 two diagnostic methods: the patient is continuously collapsed for 1 week, the incision is reduced from the left breast to the front, the depth is shallower than the front, and the incision seepage is reduced from the front. A pale tongue with a thin and red coating and a wiry pulse. The Chinese medicine is treated by the collapse method again, 7 pieces of Chinese medicine are added, and the collapse method is the same as the previous method.
Three diagnoses at 2023, 3 and 27 days: the patient is continuously collapsed for 2 weeks, the left breast incision heals, and no obvious incision seepage exists. A pale tongue with thin and white coating and a wiry pulse. The dosage of the collapse prescription is adjusted to be 60g of kusnezoff monkshood root, 30g of arisaema tuber, 60g of dried ginger, 30g of white paeony root and 15g of cassia bark, the decoction method and the collapse method are consistent, and 7 patches are added in total, and the follow-up visit is performed at present.
Case 4:
first diagnosis in 2022, 02, 18 days: patients Zhu Mou, 43 years old, were treated for "2 months after the right milk swelling and pain". Physical examination at that time: the right external upper quadrant can reach a tumor, the range is about 6cm, the quality is tough, the boundary is unclear, the activity is high, the skin is red, the fluctuation sense is provided, the ulcer is avoided, and the axillary lymph nodes can reach. Auxiliary inspection: double-emulsion B ultrasonic wave: multiple mixed echo clusters in right milk (several mixed echo clusters are visible in right milk, the larger size is about 4.1 x 1.0cm (10 points direction), 2.6 x 1.0cm (9 points direction), morphology is irregular, boundary Shang Qing, local connection to skin and nipple, internal detectable and hypoechoic light spots, no change in back echo, thickening of surrounding tissues, structural disorder), BI-RADS 3 class, consider inflammation. Western diagnosis: non-lactation mastitis. Diagnosis of traditional Chinese medicine: acne-like acute mastitis, with the symptoms of yang deficiency and congealing cold, phlegm-stasis and blood stasis. For warming yang, dispelling cold, promoting blood circulation, and removing obstruction in collaterals. Wen Yangfa yang and decoction are added for treating, and the specific prescription is as follows: 12g of prepared rehmannia root, 15g of spina gleditsiae, 15g of semen vaccariae, 15g of antler slices, 12g of white mustard seed, 6g of roasted ephedra, 9g of baked ginger charcoal, 6g of liquorice, 12g of loofah sponge and 30g of raw astragalus, wherein 7 patches of the raw astragalus are decocted to 200ml per patch of water for 2 times a day, and 100ml of the raw astragalus is taken after each meal; meanwhile, the embodiment 2 is provided with 7 specific prescription medicines: 120g of kusnezoff monkshood root, 30g of arisaema tuber, 120g of dried ginger, 30g of white paeony root and 15g of cassia bark. The 5 raw materials are decocted with water and concentrated to 100ml, when in use, a patient takes a supine position, dips the liquid medicine with sterile gauze to wet compress the affected side breast lump region, and simultaneously assists an infrared lamp to perform physiotherapy and heat preservation, and each time is 1 hour in the morning and evening, and 7 consecutive days are a treatment course.
Two diagnoses at 2022, 02, 25: after the traditional Chinese medicine is taken orally and combined with the traditional Chinese medicine for curing collapse, the wound surface of a patient is scabbed, the seepage is obviously reduced, and the body is checked: the right breast was externally reached with a mass of about 4 x 4cm, with tough mass, poor boundaries, scabbing on the mass surface, and no apparent bleeding. Auxiliary inspection: double-emulsion B ultrasonic wave: multiple mixed echo clusters in right breast (several mixed echo clusters are visible in right breast, the larger size is about 2.2 x 1.4cm (9 point direction), 2.5 x 0.7cm (10 point direction), the morphology is irregular, the boundary Shang Qing is locally connected with skin and nipple, the internal detectable and hypoechoic light spots are arranged, the back echo is unchanged, the surrounding tissues are thickened, and the structure is disordered). The traditional Chinese medicine collapse prescription is combined with the traditional Chinese medicine oral treatment, the prescription is 7 pieces before, and the collapse method is the same as before.
Three diagnoses at 2022, 3 and 4 days: the patient's crumple is basically healed, and the body is checked: the right breast was palpable with a size of about 3.5 x 3.0cm, soft, border Shang Qing, and a visible scar on the mass surface of about 3 cm. Auxiliary inspection: double-emulsion B ultrasonic wave: right milk cystic mass, BI-RADS 3, considering post-inflammatory encapsulated effusion (right milk visible as a cystic echo mass, size about 3.4 x 1.7cm (12 point direction), wall thickness, morphology rules, clear border). The Chinese medicine is stopped taking orally, and the external treatment of the original prescription of the Chinese medicine collapse prescription is continued, and the follow-up visit is continued at present.
Case 5:
first diagnosis in 2023, 4 months and 3 days: wu Mou women, 28 years old, have a diagnosis of "2 months after delivery, 2 months after left breast swelling and pain with liquid leakage". Physical examination at that time: the left breast was internally and upwardly seen with a radial incision of about 5cm in length, the upper inner quadrant reached a tumor, the range was about 4 x 6cm, the border was tough, the mobility was clear, there was a feeling of fluctuation, the lower portion of the tumor was near the lower crease wall and a skin defect of about 5 x 2cm was seen, the surface was accompanied by yellow liquid leakage, there was no obvious bleeding and spill over the double papilla, and the bilateral axillary lymph nodes did not touch the obvious tumor. Auxiliary inspection: double-emulsion B ultrasonic wave: the left milk multiple mixed echo clusters, BI-RADS 3 class, consider inflammation (left milk see several hypoechoic clusters, larger at 6-7 points, size about 7.6 x 2.6 x 6.5cm, direction 3.7 x 1.4 x 5.2cm, morphology irregularities, distributed along the catheter). Western diagnosis: non-lactation mastitis. Diagnosis of traditional Chinese medicine: acne-like acute mastitis, with the symptoms of yang deficiency and congealing cold, phlegm-stasis and blood stasis. The specific prescription medicine of the collapsing prescription 7 in the embodiment 2 is as follows: 120g of kusnezoff monkshood root, 30g of arisaema tuber, 120g of dried ginger, 30g of white paeony root and 15g of cassia bark. The 5 raw materials are decocted with water and concentrated to 100ml, when in use, a patient takes a supine position, dips the liquid medicine with sterile gauze to wet compress the affected side breast lump region, and simultaneously assists an infrared lamp to perform physiotherapy and heat preservation, and each time is 1 hour in the morning and evening, and 7 consecutive days are a treatment course.
Two diagnoses at 2023, 4 and 10 days: after the traditional Chinese medicine collapse treatment, the wound surface of a patient is obviously reduced, the seepage is reduced in comparison with the prior art, and the body is checked: the left breast was externally accessible to a 5 x 3cm mass, tough, poorly defined, and the internal upper incision was weeped, aiding in the examination: double-emulsion B ultrasonic wave: the left-breast multiple mixed echo clusters, BI-RADS 3, are distributed along the catheter, blurred in edge and locally communicated with the epidermis, considering inflammation (6-point direction: 5 x 2.5cm mixed echo clusters; 9-point direction: 4.7 x 0.8 cm), and irregular morphology. The traditional Chinese medicine is subjected to collapse treatment again, the prescription is the same as the previous prescription, 7 patches are added, and the collapse method is the same as the previous method.
Three diagnoses: three diagnoses at 2023, 4 and 17 days: the wound surface is obviously reduced before, no obvious seepage exists, and the body is checked: the tumor with the reaching range of about 3cm from the outer side to the upper side of the left breast is tough and has an unclear boundary, and the seepage of the incision on the inner side and the upper side is reduced before the previous, so that the treatment of the collapse is continued.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary or exhaustive of all embodiments. And obvious variations or modifications thereof are contemplated as falling within the scope of the present application.
Claims (7)
1. A Wen Yangfa-based traditional Chinese medicine composition for treating non-nursing-stage mastitis tumors, comprising: the collapse formula comprises the following raw materials in parts by weight:
1-12 parts of kusnezoff monkshood root, 1-6 parts of arisaema tuber, 1-12 parts of dried ginger, 1-6 parts of white paeony root and 1-3 parts of cassia bark.
2. The traditional Chinese medicine composition according to claim 1, wherein the collapse formula is composed of the following raw materials in parts by weight:
1-9 parts of kusnezoff monkshood root, 1-3 parts of arisaema tuber, 1-9 parts of dried ginger, 1-3 parts of white paeony root and 1-1.5 parts of cassia bark.
3. The traditional Chinese medicine composition according to claim 1, wherein the collapse formula is composed of the following raw materials in parts by weight: 9 parts of kusnezoff monkshood root, 3 parts of arisaema tuber, 9 parts of dried ginger, 3 parts of white peony root and 1.5 parts of cinnamon.
4. The traditional Chinese medicine composition according to claim 1, further comprising an oral traditional Chinese medicine, wherein the oral traditional Chinese medicine is yang-harmonizing soup.
5. The traditional Chinese medicine composition according to claim 1, wherein the yang and soup is composed of the following raw materials in parts by weight: 4 parts of prepared rehmannia root, 5 parts of spina gleditsiae, 5 parts of semen vaccariae, 5 parts of antler slices, 4 parts of white mustard seed, 2 parts of roasted ephedra herb, 3 parts of baked ginger charcoal, 2 parts of liquorice and 4 parts of loofah sponge.
6. A method of preparing the traditional Chinese medicine composition of claim 1, comprising the steps of:
weighing the formula amount of kusnezoff monkshood root, arisaema tuber, dried ginger, white paeony root and cassia bark;
decocting radix Aconiti Kusnezoffii, rhizoma arisaematis, rhizoma Zingiberis, radix Paeoniae alba, and cortex Cinnamomi with water, and concentrating to obtain Chinese medicinal composition.
7. Use of a traditional Chinese medicine composition according to any one of claims 1-5 for the preparation of a medicament for the prevention or treatment of a breast disease, which is a mastitis tumor.
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