CN116688335A - Drivable medicine-releasing and sampling integrated capsule - Google Patents

Drivable medicine-releasing and sampling integrated capsule Download PDF

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Publication number
CN116688335A
CN116688335A CN202310715548.3A CN202310715548A CN116688335A CN 116688335 A CN116688335 A CN 116688335A CN 202310715548 A CN202310715548 A CN 202310715548A CN 116688335 A CN116688335 A CN 116688335A
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CN
China
Prior art keywords
sleeve
shell
side wall
sampling
drivable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310715548.3A
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Chinese (zh)
Inventor
徐海峰
刘祥超
刘源
刘楚
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to CN202310715548.3A priority Critical patent/CN116688335A/en
Publication of CN116688335A publication Critical patent/CN116688335A/en
Pending legal-status Critical Current

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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The application discloses a drivable drug release and sampling integrated capsule, and relates to the technical field of medical appliances. Can realize accurate position and accurate dosage of drug targeted release in human intestinal tracts and almost noninvasive tissue sampling. The capsule comprises a housing; the shell is provided with a first external thread and an internal thread with the same rotation direction; the tail part of the device is provided with a first medicine outlet, and the head part is provided with a sampling needle; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end, and the plunger comprises a thread section and an optical axis section; the screw thread section is provided with a second external screw thread matched with the internal screw thread, the optical axis section stretches into the sleeve and can axially slide in the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the first external thread and the second external thread are both magnetic.

Description

Drivable medicine-releasing and sampling integrated capsule
Technical Field
The application relates to the technical field of medical appliances, in particular to a drivable drug release and sampling integrated capsule.
Background
Traditional treatments, such as surgery and medication, have gradually exposed some drawbacks over long periods of use. These are relatively coarse treatment modalities from the point of view of modern medical technology. For example, surgery must open a wound in the skin and may also injure tissues along the way. Traditional medicines are also used for entering blood circulation to act on the whole body, so that the traditional medicines belong to a treatment method with lower efficiency.
In addition, most of the traditional medicines ingested by swallowing pills or capsules are disposed of by the intestines and stomach, the liver, and only a small portion of the remainder enters the blood circulation, and finally a smaller portion of the small portion reaches the affected part. The physician therefore schedules the patient with a much higher amount of drug than the patient would eventually have. The excessive medicine amount inevitably brings various side effects to the patient, especially some medicines with larger side effects.
With the development of technology, more elaborate therapeutic approaches are being pursued. Such as minimally invasive, or even non-invasive, surgery to minimize trauma; such as precisely acting targeted drugs, targeted delivery, etc. Capsules are born under such a need. Due to the small enough overall size, targeted drug delivery can be achieved. The capsule is equipped with some manipulation mechanisms, such as miniature cameras, sampling needles, miniature sampling grips, etc., so that some fine operations can be performed.
For example, capsule endoscopes, which have been used in many hospitals, are used, and a patient swallows a capsule-sized endoscope, and the capsule endoscope completes a complete image of the entire length of the intestines and stomach along with the circulation of the intestines and stomach, and then the doctor checks the image. The capsule endoscope can complete the examination under the condition that the patient hardly perceives, thereby greatly relieving the pain of the patient. However, the existing capsule endoscope can only be used for detection, treatment cannot be completed, and accurate positioning cannot be realized.
Disclosure of Invention
The embodiment of the application provides a drivable drug release sampling integrated capsule which can realize the targeted release of drugs with accurate positions and accurate dosage in human intestinal tracts and almost noninvasive tissue sampling.
In order to achieve the above object, in one aspect, an embodiment of the present application provides a drivable drug-releasing and sampling integrated capsule, including a housing; the outer side wall of the shell is provided with a first external thread, and the inner side wall of the shell is provided with an internal thread; the rotation directions of the first external thread and the internal thread are the same; the tail part of the shell is provided with a first medicine outlet, and the head part of the shell is provided with a sampling needle; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end; the sleeve is in sliding connection with the shell; the plunger comprises a threaded section and an optical axis section; the second external thread matched with the internal thread is arranged on the thread section, the optical axis section stretches into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the first external thread and the second external thread are both magnetic.
Further, the first medicine outlet is a plurality of first radial holes arranged at the bottom of the side wall of the shell; the plurality of first radial holes are uniformly distributed along the circumferential direction of the shell; the second medicine outlet is a plurality of second radial holes arranged on the side wall of the sleeve; the second radial holes are in one-to-one correspondence with the positions of the first radial holes when the sleeve is run to the bottom of the housing.
Further, a convex rib extending along the axial direction is arranged on the outer side wall of the sleeve, and a sliding groove matched with the convex rib is arranged on the inner side wall of the shell.
Further, a micropuncture is arranged on the end face of the tail part of the shell.
Further, an annular groove is further formed in the inner side wall of the shell, a boss matched with the annular groove is arranged at the head of the sleeve, and the boss can slide along the axial direction of the annular groove.
In another aspect, embodiments of the present application further provide a second drivable drug-releasing and sampling integrated capsule, comprising a housing; the outer side wall of the shell is provided with a first external thread, and the inner side wall of the shell is provided with an internal thread; the rotation directions of the first external thread and the internal thread are the same; the tail part of the shell is provided with a first medicine outlet; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end; the sleeve is in sliding connection with the shell; the plunger comprises a threaded section and an optical axis section; the second external thread matched with the internal thread is arranged on the thread section, the optical axis section stretches into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the head of the plunger is provided with a driving rod; the head of the shell is provided with a limit sleeve; one end of the driving rod, which is far away from the plunger, extends out of the limit sleeve and is then connected with the sampling forceps; the first external thread and the second external thread are both magnetic.
Further, the first medicine outlet is a plurality of first radial holes arranged at the bottom of the side wall of the shell; the plurality of first radial holes are uniformly distributed along the circumferential direction of the shell; the second medicine outlet is a plurality of second radial holes arranged on the side wall of the sleeve; the second radial holes are in one-to-one correspondence with the positions of the first radial holes when the sleeve is run to the bottom of the housing.
Further, a convex rib extending along the axial direction is arranged on the outer side wall of the sleeve, and a sliding groove matched with the convex rib is arranged on the inner side wall of the shell.
Further, a micropuncture is arranged on the end face of the tail part of the shell.
Further, an annular groove is further formed in the inner side wall of the shell, a boss matched with the annular groove is arranged at the head of the sleeve, and the boss can slide along the axial direction of the annular groove.
Compared with the prior art, the application has the following beneficial effects:
1. the drivable drug release and sampling integrated capsule provided by the embodiment of the application can realize targeted and fixed-point drug release by controlling an external magnetic drive system aiming at the affected part at the intestines and stomach, thereby accurately controlling the use amount of the drug, reducing side effects and simultaneously ensuring that the affected part is fully treated by the drug.
2. The drivable drug release and sampling integrated capsule has the drug release and sampling functions, and can finish the two functions of drug release and tissue sampling after being put into the capsule once.
3. The embodiment of the application can drive the drug release and sampling integrated capsule to sample tissues, help doctors to better understand the disease condition of affected parts, avoid operation of patients, insert catheter guide wires and the like, and relieve the pain of the patients.
Drawings
In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a drug delivery and sampling capsule according to one embodiment of the present application;
fig. 2 is a schematic structural diagram of a drug delivery and sampling integrated capsule according to another embodiment of the present application.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
In the description of the present application, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; the specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
Example 1:
referring to fig. 1, an embodiment of the present application provides a drivable drug delivery sampling integrated capsule. The working environment is intestinal environment. The drivable drug release and sampling integrated capsule specifically comprises a shell 1, a sleeve 2, a plunger 3 and a sampling needle 4.
The shell 1 is of a hollow cylinder structure with a closed head and a bottom cover arranged at the tail. Specifically, the outer side wall of the shell 1 is provided with a first external thread 11, and the inner side wall is provided with an internal thread 12; the first external thread 11 and the internal thread 12 have the same rotation direction; the first external thread 11 is distributed on the outer side wall of the housing 1, and the internal thread 12 is only one section and is arranged near the head of the housing 1. The first external thread 11 and the internal thread 12 each have magnetism. In order to reduce the weight of the entire capsule, during the processing, the body of the housing 1 can be processed with plastic, and then nesting of the first external thread 11 and the internal thread 12 processed with magnetic material is nested on the outside and inside of the plastic, so that the first external thread 11 and the internal thread 12 are both magnetic. It should be noted that the housing 1 may also be directly processed by using a magnetic material, so as to ensure that the first external thread 11 and the internal thread 12 have magnetism, and a specific processing method is selected according to actual practice, which is not limited herein.
The tail end face of the shell 1 is provided with a micro-thorn 13, the top cover is provided with a through hole, the through hole is provided with a sampling needle 4, and the inner cavity of the sampling needle 4 is communicated with the inner cavity of the shell 1. In order to reduce the number of parts, the sampling needle 4 is integrally formed with the housing 1. The bottom of the side wall is provided with a first medicine outlet. The first medicine outlet is a plurality of first radial holes 14 uniformly distributed along the circumferential direction of the shell 1.
A sleeve 2 and a plunger 3 are arranged in the shell 1. Wherein the sleeve 2 is a cylinder with an opening at one end. The sleeve 2 is slidably connected to the housing 1. Specifically, the outer side wall of the sleeve 2 is provided with a rib extending along the axial direction, and the inner side wall of the shell 1 is provided with a chute 15 matched with the rib. Thereby, the sleeve 2 can be prevented from rotating when sliding. The inner side wall of the shell 1 is also provided with a ring groove 16, the head of the sleeve 2 is provided with a boss 21 matched with the ring groove 16, and the boss 21 can slide along the axial direction of the ring groove 16. Thus, the guidance can be enhanced. The annular groove 16 may be a relief groove.
The plunger 3 comprises a threaded section 31 and an optical axis section 32, the threaded section 31 is provided with a second external thread 33 which is matched with the internal thread 12, and the second external thread 33 is also magnetic. The optical axis section 32 extends into the sleeve 2 and can slide along the axial direction of the sleeve 2, and the bottom surface of the optical axis section 32, the bottom surface of the sleeve 2 and the inner side wall of the sleeve 2 enclose the medicine storage cavity 5. The drug storage chamber 5 acts as a drug reservoir in which the liquid drug is stored. A second medicine outlet is arranged on the side wall of the medicine storage cavity 5. The second medicine outlet is a plurality of second radial holes 51. The number of second radial holes 51 is equal to the number of first radial holes 14.
The plunger 3 can push the sleeve 2 to move along the axial direction of the shell 1, when the sleeve 2 is not pushed to the bottom of the shell 1, the second radial holes 51 and the first radial holes 14 are staggered, the second radial holes 51 are blocked by the side wall of the shell 1, and the medicine in the medicine storage cavity 55 cannot flow out. When the sleeve 2 moves to the bottom of the shell 1, the positions of the second radial holes 51 and the first radial holes 14 are in one-to-one correspondence, at this time, the medicine storage cavity 5 is communicated with the outside, and the plunger 3 pushes the liquid medicine in the medicine storage cavity 5 to flow out. The capsule after the installation was closed.
The working principle of the embodiment 1 of the application is as follows:
the medicine sampling integrated capsule capable of being driven to release is controlled by an external magnetic driving system, and the external magnetic driving system can apply forward and reverse rotating magnetic fields. The external magnetic drive system is prior art and will not be described in detail herein.
In order to reach the target position, the external magnetic control system applies a forward rotating magnetic field, the capsule rotates as a whole, and the capsule is screwed forward under the action of the first external thread 11 on the surface of the housing 1, and at this time, the forward trend of the plunger 3 in the housing 1 is also in the direction approaching the sampling needle 4, so that the liquid medicine is not squeezed at this time. After the capsule is moved entirely to the target site, tissue sampling or drug release may be selected. It should be noted that the tissue sampling and drug release operations may be completed sequentially, and the two operations may be completed only by tissue sampling or drug release operations.
If tissue sampling is performed, the external magnetic driving system is controlled to adjust the rotation direction of the magnetic field, so that the sampling needle 4 faces the sampling area, then the capsule is screwed forward until the sampling needle 4 pierces the tissue, then the magnetic field is rotated reversely, the capsule reversely rotates the sampling needle 4 to withdraw, and part of the tissue remains in the sampling needle 4, thereby completing the sampling operation.
If the drug release operation is performed, the magnetic field is required to rotate reversely. The capsule is reversed onto the nearby tissue wall and the micro-piercing 13 at the bottom of the capsule pierces the tissue, securing the housing 1. The magnetic field is then caused to continue to rotate in opposite directions, the plunger 3 inside the capsule being screwed in towards the bottom. Due to the incompressibility of the liquid in the drug storage cavity 5 the cartridge 2 will be pushed out first, the second radial holes 51 on the cartridge 2 being aligned with the first radial holes 14 on the housing 1. Then, the plunger 3 continues to be screwed into the bottom to slowly push the liquid medicine in the medicine storage chamber 55 out of the capsule, thereby completing the medicine release.
Example 2:
referring to fig. 2, an embodiment of the present application further provides a drivable drug delivery and sampling integrated capsule. The working environment is intestinal environment. Example 2 differs from the example only in that: in example 2, the sampling needle 4 was replaced with a sampling forceps 6. Specifically, the head of plunger 3 is equipped with actuating lever 7, and the head of shell 1 is equipped with stop collar 8, and actuating lever 7 stretches out behind the stop collar 8 and connects sampling clamp 6 away from the one end of plunger 3, and when plunger 3 axial motion, drive actuating lever 7, and then drive sampling clamp 6 closure completion sample. In order to reduce the number of components, the stop collar 8 is integrally formed with the housing 1.
The working principle of the embodiment 2 of the application is as follows:
the embodiment of the application can drive the drug-releasing and sampling integrated capsule to be controlled by an external magnetic drive system. The driving principle and the drug release principle are the same as those of example 1, and will not be described in detail here.
When tissue sampling is carried out, an external magnetic drive system is controlled to adjust the rotation direction of a magnetic field, so that the sampling forceps 6 are opened and fully embedded into the tissue, at the moment, the inside of the sampling forceps 6 contains tissue blocks, the outside of the sampling forceps 6 is wrapped by the tissue, then the magnetic field is reversely rotated, the traction force transmitted to the sampling forceps 6 by the plunger 3 can enable the sampling forceps 6 to be closed first, then, the capsule is continuously reversely driven due to the reduction of the resistance between the sampling forceps 6 and the tissue, and the sampling forceps 6 can be separated from the tissue, so that the sampling process is completed.
The present application is not limited to the above embodiments, and any changes or substitutions within the technical scope of the present application should be covered by the scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims (10)

1. A drivable drug-releasing and sampling integrated capsule, which is characterized by comprising a shell; the outer side wall of the shell is provided with a first external thread, and the inner side wall of the shell is provided with an internal thread; the rotation directions of the first external thread and the internal thread are the same; the tail part of the shell is provided with a first medicine outlet, and the head part of the shell is provided with a sampling needle; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end; the sleeve is in sliding connection with the shell; the plunger comprises a threaded section and an optical axis section; the second external thread matched with the internal thread is arranged on the thread section, the optical axis section stretches into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the first external thread and the second external thread are both magnetic.
2. The drivable drug delivery and sampling integrated capsule of claim 1, wherein the first drug outlet is a plurality of first radial holes disposed at the bottom of the side wall of the housing; the plurality of first radial holes are uniformly distributed along the circumferential direction of the shell; the second medicine outlet is a plurality of second radial holes arranged on the side wall of the sleeve; the second radial holes are in one-to-one correspondence with the positions of the first radial holes when the sleeve is run to the bottom of the housing.
3. The drivable drug release and sampling integrated capsule according to claim 1, wherein the outer side wall of the sleeve is provided with a rib extending along the axial direction, and the inner side wall of the housing is provided with a chute matched with the rib.
4. The drivable drug release and sampling integrated capsule of claim 1, wherein the tail end face of the housing is provided with a micropuncture.
5. The drivable drug release and sampling integrated capsule according to claim 1, wherein the inner side wall of the housing is further provided with a ring groove, the head of the sleeve is provided with a boss adapted to the ring groove, and the boss can slide along the axial direction of the ring groove.
6. A drivable drug-releasing and sampling integrated capsule, which is characterized by comprising a shell; the outer side wall of the shell is provided with a first external thread, and the inner side wall of the shell is provided with an internal thread; the rotation directions of the first external thread and the internal thread are the same; the tail part of the shell is provided with a first medicine outlet; a sleeve and a plunger are arranged in the shell; the sleeve is a cylinder with an opening at one end; the sleeve is in sliding connection with the shell; the plunger comprises a threaded section and an optical axis section; the second external thread matched with the internal thread is arranged on the thread section, the optical axis section stretches into the sleeve and can slide along the axial direction of the sleeve, and the bottom surface of the optical axis section, the bottom surface of the sleeve and the inner side wall of the sleeve enclose Chu Yaoqiang; a second medicine outlet is arranged on the side wall of the medicine storage cavity; the plunger can push the sleeve to move along the axial direction of the shell; when the sleeve moves to the bottom of the shell, the first medicine outlet is communicated with the second medicine outlet; the head of the plunger is provided with a driving rod; the head of the shell is provided with a limit sleeve; one end of the driving rod, which is far away from the plunger, extends out of the limit sleeve and is then connected with the sampling forceps; the first external thread and the second external thread are both magnetic.
7. The drivable drug delivery and sampling integrated capsule of claim 6, wherein the first drug outlet is a plurality of first radial holes disposed at the bottom of the side wall of the housing; the plurality of first radial holes are uniformly distributed along the circumferential direction of the shell; the second medicine outlet is a plurality of second radial holes arranged on the side wall of the sleeve; the second radial holes are in one-to-one correspondence with the positions of the first radial holes when the sleeve is run to the bottom of the housing.
8. The drivable drug release and sampling integrated capsule according to claim 6, wherein the outer side wall of the sleeve is provided with a rib extending along the axial direction, and the inner side wall of the housing is provided with a chute adapted to the rib.
9. The drivable drug release and sampling integrated capsule of claim 6, wherein the tail end face of the housing is provided with a micropuncture.
10. The drivable drug release and sampling integrated capsule of claim 6, wherein the inner side wall of the housing is further provided with a ring groove, the head of the sleeve is provided with a boss matched with the ring groove, and the boss can slide along the axial direction of the ring groove.
CN202310715548.3A 2023-06-16 2023-06-16 Drivable medicine-releasing and sampling integrated capsule Pending CN116688335A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310715548.3A CN116688335A (en) 2023-06-16 2023-06-16 Drivable medicine-releasing and sampling integrated capsule

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310715548.3A CN116688335A (en) 2023-06-16 2023-06-16 Drivable medicine-releasing and sampling integrated capsule

Publications (1)

Publication Number Publication Date
CN116688335A true CN116688335A (en) 2023-09-05

Family

ID=87827328

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310715548.3A Pending CN116688335A (en) 2023-06-16 2023-06-16 Drivable medicine-releasing and sampling integrated capsule

Country Status (1)

Country Link
CN (1) CN116688335A (en)

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