KR20140137308A - Intracerebral drug injection device, the assembly for installing the injection device, and a method for delivering cerebropathy treatment drugs into the human brain - Google Patents

Abstract

An intracerebral drug injecting device according to the present invention comprises: a chamber (103) having an open surface, a concave internal space (135), and a projection (138) formed on the bottom surface (131a) thereof; a catheter (140) which is a member having a thin and long tube shape and has a distal end (142) inserted in the projection (138) of the chamber (130); a catheter fixing cap (150) coupled with the projection (138) of the chamber (130) to fix the distal end (142) of the catheter (140) to the projection (138) of the chamber (130); a blocking disc (170) inserted in the internal space (135) of the chamber (130) to block the open surface of the chamber (130); and a top cap (160) inserted in the internal space (135) of the chamber (130) and disposed at the top of the blocking disc (170). The intracerebral drug injecting device can be used in administrating stem cell or cerebropathy treating drugs to the overall cerebral part.

Description

Technical Field [0001] The present invention relates to an intra-cerebral drug infusion device, an assembly for installing a drug infusion device in a brain, and a method for administering a cerebral disease therapeutic drug,

[0001] The present invention relates to a drug injecting device, an assembly for installing a drug injector in a brain, and a method of administering a drug for treating a brain disease. More particularly, the present invention relates to a drug injecting device for injecting a brain drug into a brain of a patient suffering from Alzheimer ' An intracerebral drug injection device and an intravenous drug injection device assembly for allowing a user to easily and repeatedly administer stem cells in the future when the device is to be administered for a long period of time, and an intravenous drug injection device The present invention relates to a method of administering a stem cell or a therapeutic drug to the brain of a patient having brain disease such as Alzheimer ' s Dementia.

Alzheimer's disease is the most common degenerative brain disease that causes dementia and was first reported in 1907 by Dr. Alois Alzheimer, a German psychiatrist. Alzheimer's disease is a disease in which brain tissue declines in functioning of the brain in the course of aging, and its mental function declines gradually. The characteristic of this disease is that it causes severe disturbances in memory and emotion. In modern medicine, S disease '.

Patients with Alzheimer's disease initially show problems in their memory of recent work, and with the onset of illness, they are accompanied by other abnormalities of cognitive function such as language function and judgment, and eventually they lose all their daily life functions.

Alzheimer's type dementia is one of the major causes of dementia in the elderly, and its histologic features include general atrophy of the brain, enlargement of the ventricles, multiple lesions of the nerve fibers and hyperchromatic spots.

In the United States, about 3% of the population aged 65 to 74, about 19% of the population aged 75 to 84, and 50% of the population aged 85 or older are suffering from this disease. In recent years, About 21% of people aged 60 years or older in the rural area have dementia, and 63% of them are reported to be Alzheimer-type dementia. Along with the rapid increase in the elderly population due to the aging society, the number of patients with Alzheimer's disease is expected to increase further.

The research team of the present inventors is studying a method of treating stem cells in a patient's brain by injecting the stem cells into a brain for treatment of such a severe Alzheimer's type dementia patient. In March 2011, ) And the world's first direct injection of stem cells into the patient's brain. As a result, "Stability and Potential Therapeutic Effectiveness of Neurosemide-AD (Human Umbilical Cord Blood Derived Stem Cells) in Alzheimer's Disease Patients Has been completed for the first phase of Phase I clinical trials. The safety of stem cells (neurostem-AD) has already been demonstrated through Phase I clinical trials in a single institute, and stem cells (neuroses) have been shown to have a sustained in- Have been reported to have.

In order to maximize the therapeutic effect of Alzheimer's dementia using stem cells, it is most important to repeatedly administer the stem cells to the precise position in the patient's brain. However, until now, there have been no apparatuses capable of administering stem cells into the brain and treatment of Alzheimer's disease using the same. Therefore, there have been many difficulties in the method of administering stem cells into the brain of a patient.

In addition, the delivery device used for the administration of stem cells at present has a risk that the accuracy of the procedure may be lowered because the guide is bent and it can not be put in the correct position even if it is applied to the navigation system for brain surgery. This problem is also applied to the case of repeated administration. Especially, in case of repeated administration to the same site, accuracy of the guide and re-operation greatly influence the patient's satisfaction and expectation of the performance at the time of surgery.

The inventor of the present invention has recognized such problems and has developed a stem cell injector capable of directly and precisely microinjecting a lesion in the brain without immune rejection of the brain in a state of being implanted in the brain for a long period (about 6 months) We will develop a device and use it to construct a procedure that is highly compatible with biotransplantation so as to eliminate the need for additional repeat surgery. In particular, we intend to develop a drug dispensing device that can be used widely for cell delivery and transplantation for brain cell reconstruction, and deliver the drug directly to the lesion.

For this reason, there has been a need to develop a new type of stem cell or brain disease therapeutic drug injection device that can help repetitively and easily administer stem cell and other brain disease treatment drugs to the precise location of the lesion in the brain.

In order to solve the above problems, the present invention provides a stem cell or brain disease therapeutic drug injecting device having a catheter extending to a brain lesion in a skull of a patient suffering from a brain disease such as Alzheimer's dementia, It is an object of the present invention to provide an intra-cerebral drug-injecting device capable of easily and repeatedly administering a stem cell or a cerebral disease therapeutic drug whenever a disease-treating drug is to be administered.

It is another object of the present invention to provide an assembly for installing an intra-cerebral drug infusion device in which a position of a catheter can be precisely positioned at a lesion in a patient's brain by making it possible to precisely adjust the position by movement of a hand of a doctor, .

According to the present invention, a drug injector is installed on a head of a patient by using an assembly for injecting a device for injecting a drug into the brain, firstly administering a drug for treating a stem cell or a brain disease, Which is capable of maximizing the therapeutic effect of brain diseases such as Alzheimer ' s dementia by repeatedly administering the drug to the brain.

In order to achieve the above object, a drug injection device for a brain provided by the present invention includes a chamber 130 having a hollow surface 135 and a protrusion 138 formed on a bottom surface 131a; A catheter 140 having an elongate tubular member, the distal end 142 of the catheter fitting into a projection 138 of the chamber 130; A catheter securing cap 150 coupled to the projection 138 of the chamber 130 to secure the distal end 142 of the catheter 140 to the protrusion 138 of the chamber 130; A blocking disk (170) inserted into the inner space (135) of the chamber (130) to block the open surface of the chamber (130); And an upper cap 160 fitted in the inner space 135 of the chamber 130 and positioned above the blocking disc 170. The upper cap 160 may be used to treat all of the parenchyma regions, ≪ / RTI >

In order to achieve the above object, an 'assembly for injecting a drug into the brain' for repeated administration of a drug for treatment of a stem cell or a brain disease provided by the present invention has an internal space 135 of one side open and a concave shape A chamber 130 having a projection 138 on a bottom surface 131a; A catheter 140 having an elongate tubular member, the distal end 142 of the catheter fitting into a projection 138 of the chamber 130; A catheter securing cap 150 that engages a protrusion 138 of the chamber 130 to secure the distal end 142 of the catheter 140 to the protrusion 138 of the chamber 130; And a grip part 112 extending from a distal side of the body part 111. The guide part 115 is formed through the guide part 115 along a central axis of the body part 111 And a guide 120 having a guiding hub 110 and one end inserted and fixed in the guide coupling hole 115 of the guiding hub 110.

In order to achieve the above object, the present invention provides a method of administering a stem cell or brain disease treating drug for treating Alzheimer's dementia, which comprises the steps of: (a) administering to a patient (P) having a brain degenerative disease including Alzheimer's disease, A first step of drilling a hole of the skull 10b of the body 10a; (b) inserting the 'intraocular drug-injecting device mounting assembly' 100 into the parenchyma 15 of the patient P through the hole to allow the proximal end of the catheter 140 to reach the lesion 12 of the patient P And then fixing the chamber 130 of the assembly 100 to the patient's skull 10b; (c) separating and removing the guiding hub 110 from the chamber 130, thereby removing the guide 120 as well; (d) By inserting the needle 181 of the syringe 180 containing the stem cell 185 or the cerebral disease therapeutic drug into the chamber 130, the syringe needle 181 is inserted into the inside of the catheter 140 To reach the lesion (12) through a fourth step; (e) activating the syringe 180 to administer the stem cell 185 or a drug for treating brain diseases to the lesion 12, and then removing the syringe 180; And (f) placing a silicon blocking disc 170 in the chamber 130 and then coupling the upper cap 160 to the chamber 130, wherein the ' The assembly 100 includes a chamber 130 having a hollow interior surface 135 with an open surface and a protrusion 138 formed on the bottom surface 131a and an elongate tubular member having a distal end 142, A distal end 142 of the catheter 140 may be coupled to the chamber 130 by being coupled to a protrusion 138 of the chamber 130. The catheter 140 may include a catheter 140, And a grip portion 112 extending from the distal portion of the body portion 111. The catheter fixing cap 150 is fixed to the protrusion 138 of the body portion 111, A guiding hub 110 having a guide coupling hole 115 formed through its central axis, And a guide 120 inserted and fixed to the guide coupling hole 115 of the guiding hub 110.

Since the catheter is directly connected to the brain lesion site by long-term implantation into the skull of a patient suffering from Alzheimer's dementia or brain disease, the drug injecting apparatus according to the present invention can be used for repeatedly injecting a stem cell or brain disease- There is an advantage that the administration operation can be performed very easily and safely. In particular, in order to administer stem cell or brain disease treatment drug, general anesthesia is not necessary to the patient, and only the skin of the head part is slightly incised, so that stem cell or brain disease treatment drug can be administered through a drug injection device in the brain, And the patient's physical pain and economic burden can be greatly reduced.

In addition, 'the assembly for injecting a drug injecting device according to the present invention' is installed on the head of a patient in a state where the position is accurately detected in real time using a navigation system for brain surgery sensed by a three dimensional ultrasonic method, So that it is possible to precisely perform the installation.

Meanwhile, a method of administering a stem cell or a therapeutic drug for treating brain diseases including Alzheimer's disease, including dementia according to the present invention, is not limited to the precise installation of the first intracerebral drug injection device, The therapeutic effect of Alzheimer's dementia using stem cells and the effect of treating brain diseases using drugs for treating brain diseases can be maximized by making it possible to inject drugs for treating stem cells or brain diseases in a simple manner. The present invention eliminates the need for a large surgical operation to repeatedly administer a stem cell or brain disease treating drug to the brain after the drug injection device is installed in the brain once, thereby alleviating the physical pain of the patient It has the advantage of lowering the cost of surgery.

The present invention realizes next-generation stem cell therapy for reconstructing brain cells by transplanting a minute amount of intermittently repeated cells directly into a lesion, maximizing therapeutic effect and constructing a cell delivery implantable system to brain tissue, It will be possible to preempt the international technology competitiveness. In addition, the novel injection device of the present invention has an effect of making a clinical approach to a method of intermittently and repeatedly directly implanting stem cells into a brain tumor for the purpose of brain cell reconstruction and healing of a brain disease patient such as Alzheimer's dementia, The present invention has the effect of enabling a therapeutic method of administering therapeutic drugs directly into a patient's brain for the treatment of various other brain diseases.

The present invention relates to a device for repeatedly administering a stem cell to a parenchyma region of a patient suffering from Alzheimer's disease, and has high biocompatibility for long-term implantation, so that intermittent repeated or continuous micro-quantitative injection into a direct lesion in the brain can be performed. Further, it may be used to administer stem cells to patients suffering from degenerative brain diseases other than Alzheimer's disease and patients suffering from trauma other than brain diseases. The intracerebral drug injection device and the method of the present invention can be applied to the early patients of degenerative brain diseases such as dementia to show the effect of prevention and it is expected to expand into a new industrial field such as stem cell transplantation do.

FIG. 1 shows a procedure for installing a drug injection device in the brain according to the present invention by using a navigation system for brain surgery (1) in a head of a patient with Alzheimer's disease (P).
FIG. 2 is a block diagram illustrating a procedure for installing a drug injector in a brain by using a navigation system for brain surgery 1 of FIG. 1 on a head of a patient with Alzheimer's disease.
FIG. 3 is a top view showing the position of a lesion to be treated with a stem cell using an intra-cerebral drug injection device according to the present invention on an MRI image of a patient's head.
FIGS. 4 and 5 are exploded views of 'an assembly for installing a drug injection device in a brain' 100 for repeated administration in the brain of a stem cell or a brain disease treating drug according to the present invention, wherein FIG. 4 is an exploded perspective view And Fig. 5 is shown in the exploded sectional view.
FIG. 6 is a degradation-binding diagram of an intracerebral drug injector 101 for repeated administration in the brain of a stem cell or brain disease treating drug according to the present invention.
FIG. 7 illustrates a coupling relation between a guiding hub 110 and a guide 120 in the 'intraocular drug-injecting device mounting assembly 100' shown in FIG.
8 is a detailed view of the configuration of a chamber 130 in the 'intraocular drug-injecting device mounting assembly 100' shown in FIG. 4. FIG. 8 (a) is a side view of the chamber 130 And FIG. 8 (b) is a side sectional view of the chamber 130.
9 is a detailed view of the configuration of the catheter fixing cap 150 among the 'intraocular drug-injecting device mounting assembly 100' shown in FIG. 4. FIG. 9 (a) And Fig. 9 (b) is a side sectional view of the catheter fixing cap 150. Fig.
10 is a perspective view of the upper cap 160 of the drug intramuscular injection device 101 shown in FIG.
FIG. 11 shows a state in which 'an assembly for installing a drug injection device in a brain' 100 according to the present invention is assembled and then mounted on the surgical equipment 20.
12 shows a state in which 'an assembly for installing a drug injection device in a brain' 100 according to the present invention is installed on a head 10 of a demented Alzheimer's patient.
FIG. 13 is an enlarged view of the 'intravenous drug injection device mounting assembly' 100 shown in FIG.
14 to 16, the guiding hub 110 and the guide 120 are removed from the 'intraocular drug injection device mounting assembly 100' installed on the patient's skull 10b (Fig. 14), and then the syringe needle 181 (FIG. 15 and FIG. 16). FIG. 15 and FIG. 16 show the process of injecting the stem cells 185 into the catheter 140.
17 shows a state in which the barrier disc 170 and the upper cap 160 are filled in the chamber 130 after the primary stem cell administration is completed in the patient's brain and FIG. The skin 13 is completely covered with the drug infusion device 101 in the brain.
19 shows a process of inserting a syringe needle 181 into an intra-cerebral drug injector 101 installed in a head of a patient when the stem cells are repeatedly administered to the brain of a patient with Alzheimer's dementia, The stem cells 185 in the syringe 180 are administered to the lesion in the patient's brain.
21 and 22 show a navigation system for brain surgery displaying the position of the guide 120 in real time on the image data of a magnetic resonance imaging (MRI) apparatus 120 ', wherein FIG. FIG. 22 is an image when the guide 120 is inserted into the upper wedge lobe 12c of the patient's brain.
23 and 24 show a modification of the coupling structure of the guiding hub 110 and the guide 120 according to the second embodiment of the present invention. 23 is a perspective view of the guiding hub 110 and the guide 120, and FIG. 24 is a cross-sectional view of the guiding hub 110 and the guide 120 in a combined state.
25 is an exploded perspective view showing the structure of the chamber 200 used in the third embodiment of the present invention.
26 is an assembled perspective view of the chamber 200 shown in Fig.
27 is a cross-sectional view of the chamber 200 shown in Fig.
28 is a sectional view of the cover member 241 shown in Fig.
29 is a sectional view of the chamber main body 231 shown in Fig.
Fig. 30 is a view showing the state in which the chamber 200 shown in Fig. 26 is coupled with the catheter 140. Fig.
31 shows a state in which the needle 181 of the syringe 180 is inserted into the needle guide tube 250 while the needle guide tube 250 is inserted into the inner space 135 of the chamber 200 Fig.
32 shows a state in which one end of the needle guide tube 250 is inserted into the inner space 135 of the chamber 200 while the needle 181 of the syringe 180 is inserted into the needle guide tube 250 And the like.

Hereinafter, the structure and effect of the intra-cerebral drug injection device, the assembly for injecting the drug injector in the brain, and the intravenous administration method of the cerebral disease therapeutic drug according to the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 shows a procedure for installing a drug injection device in the brain according to the present invention by using a navigation system for brain surgery (1) in a head of a patient with Alzheimer's disease (P). Referring to FIG. 1, an 'intravenous drug infusion device mounting assembly 100' (see FIG. 4), which will be described later, is coupled to a probe 7 and installed in a head 10 of a patient P, Is detected in real time by the navigation system 1 for brain surgery and displayed on the monitor 3. [ The magnetic resonance imaging (MRI) data is displayed on the monitor 3 of the navigation system for brain surgery 1 and the position of the probe 7 or the catheter 140 is displayed on the magnetic resonance imaging data in real time .

The sensor unit 4 of the navigation system for brain surgery 1 emits ultrasonic waves and senses the ultrasonic waves reflected back from the object. The ultrasonic waves emitted from the sensor unit 4 are transmitted to the head fixing apparatus 9 And reflected by the reflectors 7a and 8 positioned in the reflector. The reflectors 8 fixed to the periphery of the head fixing device 9 maintain a predetermined position together with the head 10 of the patient and serve as a reference point for determining the positional coordinates of the head 10 of the patient And the position of the reflector 7a in the probe 7 is changed along with the probe, so that the current position of the catheter 140 can be grasped by grasping the position of the reflectors 7a.

The scanner 11 scans the head shape of the patient three-dimensionally by shooting the scanning light beam 11a onto the head 10 of the patient P. [ When the data about the head shape of the patient scanned by the scanner 11 matches the image data 6 of the MRI equipment that has been secured in advance, Can be displayed on the MRI image 6 of the monitor 3 in real time. In FIG. 1, the position (120 ') of a guide is displayed on the MRI image (6) in a linear shape, which corresponds to the position of the catheter (140). The practitioner can see the indication of the linear shape displayed on the MRI image 6 and know how the current catheter 140 is positioned in the head of the patient.

In FIG. 1, reference numeral 2 denotes a main body of a navigation system for brain surgery. Reference numeral 3a denotes a support portion supporting the monitor 3 on the main body 2, and 5 denotes a connection support for supporting the sensor portion 4.

FIG. 2 is a block diagram illustrating a procedure for installing a drug injector in a brain by using a navigation system for brain surgery 1 of FIG. 1 on a head of a patient with Alzheimer's disease.

The MRI image data 6 photographed by the MRI apparatus 60 is stored in the navigation system 1 for brain surgery and when the scanner 11 scans the face and head of the patient, Dimensional image is generated. The processor 2a of the navigation system 1 matches the three-dimensional image of the head shape with the MRI image data 6 to generate MRI image data directly associated with the head shape of the patient. When the sensor unit 3 (Fig. 1) of the navigation system detects the probe unit 7 in this state, the position of the probe unit 7 automatically calculated according to the position of the probe unit 7 or the position of the probe unit 7 The position is displayed in real time on the MRI image in a linear form.

FIG. 3 shows the position of a lesion to which stem cells are to be administered using an intra-cerebral drug injection device according to the present invention on an MRI image 10a of a head of a patient. The left hippocampus 12a, the right hippocampus 12b and the right precuneus 12c are displayed on the head MRI image 10a shown in FIG. 3, The location of the lesion in the brain for administering stem cells using the injection device is the left hippocampus 12a, the right hippocampus 12b and the right wedge lobe 12c. In case of Alzheimer's dementia, since the left and right hippocampus 12a and 12b and the right wedge lobe 12c are the first to regenerate nerve cells, the present invention first aims at administering stem cells to these lesion positions Respectively.

In Fig. 3, reference numeral 10b denotes a skull, and 15 denotes a parenchyma.

FIGS. 4 and 5 are exploded views of 'an assembly for installing a drug injection device in a brain' 100 for repeated administration in the brain of a stem cell or a brain disease treating drug according to the present invention, wherein FIG. 4 is an exploded perspective view And Fig. 5 is shown in the exploded sectional view.

The intra-cerebral drug infusion device mounting assembly 100 according to the present invention includes a chamber 130, a catheter 140, a catheter fixing cap 150, a guiding hub 110, and a guide 120 do. The chamber 130 is similar in shape to a bowl and is open on one side and has a concave inner space 135 (FIG. 5). A protrusion 138 is formed on the bottom surface 131a of the chamber 130. The protrusion 138 includes a cylindrical first protrusion 133 and a second protrusion 134 having a cone shape . A male screw portion 133a is formed around the first projection 133 and the male screw portion 133a corresponds to the female screw portion 152 formed on the inner surface of the catheter fixing cap 150. As shown in FIG. An arm portion 132 protruding toward the outer side is formed at a peripheral portion of the chamber 130. A bolt hole 132a is formed in the arm portion 132. [

The catheter 140 is an elongated tubular member whose distal end 142 is fitted to the second projection 134 of the chamber 130 and the remaining portions including the proximal end 141 are connected to a catheter And can be inserted into the through hole 151 of the fixed cap 150. When the catheter securing cap 150 is coupled to the projection 138, the distal end 142 of the catheter 140 is tightly coupled to the chamber 130. The proximal end portion 141 of the catheter 140 refers to the portion of the catheter 140 positioned closer to the lesion when the catheter 140 is inserted into the patient's body and the distal end portion 142 On the contrary, it refers to the part far from the patient's lesion. The proximal end 141 of the catheter 140 is sharpened in a tapered manner so that it can be easily inserted into brain tissue.

The guiding hub 110 is a component that serves to support the guide 120. The guide coupling hole 115 is extended in the longitudinal direction along the center axis CL, A guide 120 is coupled to the hole 115. The guiding hub 110 includes a cylindrical body portion 111 and a grip portion 112. The side surface 113 of the body portion 111 is provided with a hook or a hook having an L- Grooves 111a are formed. The portion of the proximal surface 116 at the position where the latching groove 111a is formed remains as the latching jaw 111b.

The grip portion 112 is a member for holding and handling the assembly in the process of installing 'the intraocular drug-injecting device mounting assembly' 100 on the patient's skull. When the doctor directly inserts the above-described 'intraocular drug-implanting device mounting assembly' 100 into the skull, the user can use the grip 112 with the probe unit 7 (see FIG. 1) In the case of inserting the 'intraocular drug injection device mounting assembly' 100 into the skull using the device 20, the grip part 112 may be coupled to the gripping device part 21 of the treatment device 20 (See FIG. 11)

Meanwhile, the guide 120 is made of a thick material that can be inserted into the internal space of the catheter 140, and must be made of a material having high strength since it should not be bent when inserted into brain tissue. Accordingly, it is preferable that the guide 120 is made of at least one of metal materials including titanium, nitinol, and stainless steel.

The distal end portion 121 corresponding to the 'proximal end portion' of the guide 120 is sharpened at its tip and a threaded portion 122 is formed on the surface of the opposite end ('distal portion'). When the guide 120 is inserted into the guide coupling hole 115 of the guiding hub 110 and rotated, the guide 120 is further inserted into or out of the guide coupling hole 115 according to the rotation direction of the guiding coupling hole 115, It is possible to appropriately set the length of the guide 120 protruding from the guiding hub 110 according to the distance from the proximal surface 116 of the hub 110 to the lesion.

5, a female screw portion 115a is formed in a guide coupling hole 115 formed in the longitudinal direction of the guide 120. The female screw portion 115a is provided with a male screw portion 122 ) Are combined. The guide 120 is inserted into the guide coupling hole 115 of the guiding hub 110 by a length of the thread 122. When the guide 120 is inserted into the catheter 140, The length of the guide 120 protruding out of the guiding hub 110 is adjusted so that the distal end 121 of the guiding hub 110 can be positioned at the proximal end 141 of the catheter 141. [

Figure reference numeral A ₁ eseo 5 is a full length in the longitudinal direction of the guiding hub (110), A ₂ is the length of the gripper (112), A ₃ is the length of the body portion (111), A ₄ is Is the diameter of the body portion 111.

According to the design of the preferred embodiment of the present invention, the specific size specification of the guiding hub 110 is such that the total length A ₁ is 16 mm and the length A ₂ of the grip 112 is 10 mm , was a length (a ₃₎ it is 6㎜ the body portion 111. The diameter A ₅ of the grip portion 112 was 2.80 mm and the diameter A ₄ of the body portion 111 was 10.81 mm.

5, when the distal end portion 142 of the catheter 140 is fitted in the second projection 134 of the chamber 130, the catheter fixing cap 150 is inserted into the first projection 133 The distal end 142 of the catheter 140 is pressed by the inner pressing wall 153 of the catheter securing cap 150 and the position thereof is securely fixed.

4 and 5, the guiding hub 110 and the guide 120 of the intraocular drug-delivery device mounting assembly 100 may be temporarily or permanently used only until the assembly 100 is installed in the skull Once the assembly 100 is installed in the skull, the guiding hub 110 and guide 120 are removed from the chamber 130 and removed. After the guiding hub 110 and the guide 120 are removed from the chamber 130, the blocking disc 170 and the upper cap 160 are coupled to each other in the chamber 130 as shown in FIG. Thereby completing the "intracranial drug injection device" 101 implanted in the patient's skull for a long period of time.

FIG. 6 is a degradation-binding diagram of an intracerebral drug injector 101 for repeated administration in the brain of a stem cell or brain disease treating drug according to the present invention. Comparing the 'intravenous drug injection device' 101 shown in FIG. 6 with the 'intravenous drug injection device installation assembly' 100 shown in FIGS. 4 and 5, the guiding hub 110 and the guide 120 are missing There is a difference in that a blocking disk 170 and an upper cap 160 are added.

The blocking disk 170 is a thin disk made of a silicon material and inserted into the inner space 135 of the chamber 130 to block the open surface of the chamber 130, Is coupled onto the blocking disc (170).

The blocking disk 170 has elasticity that can be restored to its original shape even if a pointed object such as a needle is pierced and then removed.

As in the case of the guiding hub 110 (see Fig. 4), the upper cap 160 is formed with an engagement groove 161a having an L-shape or an L-shape on its side surface 163 , The portion of the proximal surface 162 at the position where the latching groove 161a is formed remains as the latching protrusion 161b. A through hole 165 is formed at the center of the upper cap 160.

FIG. 7 illustrates a coupling relation between a guiding hub 110 and a guide 120 in the 'intraocular drug-injecting device mounting assembly 100' shown in FIG. An overall length (C ₁₎ from the length of the portion of the screw portion 122 formed in the guide 120. Referring now to 7 is as C _3, C ₂ indicates the length of a portion except for the screw portion (122). The guide 120 may be formed in the form of a rod or in the form of a pipe.

8 is a detailed view of the configuration of a chamber 130 in the 'intraocular drug-injecting device mounting assembly 100' shown in FIG. 4. FIG. 8 (a) is a side view of the chamber 130 And FIG. 8 (b) is a side sectional view of the chamber 130.

8A, reference symbol D ₁ denotes a length from the end of one arm 132 of the chamber 130 to the other end of the arm 132, D ₂ denotes a length of the chamber 130 itself excluding the arm 132, D ₃ denotes the thickness (height) of the chamber 130, D ₄ denotes the thickness of the first protrusion 133, and D ₅ denotes the thickness (height) of the second protrusion 134.

The maximum length D _{1 in the} radial direction of the chamber 130 is 21.07 mm and the length of the chamber 130 excluding the arm portion 132 is 21.07 mm. The height D ₃ of the chamber 130 is 3.96 mm and the height D ₄ of the first projection 133 is 1.80 mm and the outer diameter D _{2 of} the first projection 133 is 15.01 mm, (D ₅ ) of the lower electrode 134 was 3.0 mm. The inner diameter D ₆ of the chamber 130 shown in FIG. 8 (b) was 10.80 mm.

The size of the chamber 130 may be important since the chamber 130 is a prominent part when the intramuscular drug injection device of the present invention is fixed to the patient's skull. According to the actual design of the present invention, the chamber 130 of the present invention has a maximum width D ₁ of 21.07 mm and a total thickness D ₃ + D ₄ + D ₅ of about 10 mm, have. Therefore, even if the intravenous drug infusion device of the present invention is installed on the head of a patient, it would not cause great inconvenience to the daily life if the skin is covered.

Inner protrusions 135a protrude from the inner wall surface of the chamber 130 as shown in FIG. 8 (b), and the inner protrusions 135a protrude from the engaging grooves (not shown) of the guiding hub 110 111a and the upper cap 160, respectively. The inner space of the first protrusion 133 of the chamber 130 is an inner space 136 of a cone type and the center of the second protrusion 137 is formed with a first through- (Not shown).

9 is a detailed view of the configuration of the catheter fixing cap 150 among the 'intraocular drug-injecting device mounting assembly 100' shown in FIG. 4. FIG. 9 (a) And Fig. 9 (b) is a side sectional view of the catheter fixing cap 150. Fig.

In FIG. 9A, E ₁ indicates the diameter of the catheter fixing cap 150, E ₃ indicates the height of the catheter fixing cap 150, and E ₂ indicates the diameter of the end portion of the tapered portion 156. In FIG. 9 (b), E ₄ indicates the inner diameter of the through hole 151, and E ₅ indicates the thickness of the portion excluding the female screw portion 152. The internal pressurizing wall surface 153, which is formed in the inner space of the catheter fixing cap 150 and is formed next to the female thread 152, has a smaller diameter in a tapered shape toward the through hole 151. 9 (b), reference numeral 154 denotes an inlet hole of the catheter fixing cap 150.

According to one design the size specification of the catheter fixing cap 150 in accordance with a preferred embodiment of the invention, the diameter (E ₁₎ of the catheter fixing cap 150 has a length 6.82㎜ and (E ₃₎ is 4.0㎜, passed The outer diameter E ₂ of the hole 151 is 2.42 mm and the inner diameter E ₄ is 1.65 mm. And the horizontal length E ₅ of the inner compression wall surface 153 is 2.20 mm.

FIG. 10 is a perspective view of the upper cap 160 in the drug instillation apparatus 101 shown in FIG. 6, and shows the opposite side of the side shown in FIG. Accordingly, the distal surface 166 of the upper cap 160 can be seen. A plurality of the rotating sockets 167 are formed in the distal surface 166 with a predetermined depth. The rotary sockets 167 are made to allow the upper cap 160 to be pivoted when it needs to be coupled to the chamber 130 or rotated to separate it from the chamber 130.

FIG. 11 shows a state in which 'an assembly for installing a drug injection device in a brain' 100 according to the present invention is assembled and then mounted on the surgical equipment 20. Referring to FIG. 11, the 'assembly for installing an intra-cerebral drug injection device' 100 in which the assembly is completed allows the inner protrusion 135a of the chamber 130 to be inserted into the locking groove 111a of the guiding hub 110, And the guide 120 is inserted into the inner space of the catheter 140. When the grasping portion 112 of the guiding hub 110 is coupled to the grasping portion 21 of the surgical instrument 20, the position of the guiding hub 110 is precisely controlled by the surgical instrument 20 As a result, the position of the entire 'intra-cerebral drug infusion device mounting assembly' 100 can be precisely controlled.

12 shows a state in which 'the assembly 100 for installing a drug injection device in the brain' according to the present invention is installed on the head 10 of a patient with Alzheimer's disease. (100) is installed on the skull 10b of the patient. In Figure 12, the end of the catheter 140 directly enters the lesion site 12 in the brain parenchyma 15.

In FIG. 12, reference numeral 13 denotes a skin that has been cut for a procedure.

FIG. 13 is an enlarged view of the 'intravenous drug injection device mounting assembly' 100 shown in FIG. After the chamber 130 is installed in the hole formed by perforating the skull 10b of the patient's head, the fixing bolt 132b is inserted into the bolt hole 132a of the arm portion 132 of the chamber and fixed to the skull 10b.

14 to 16, the guiding hub 110 and the guide 120 are removed from the 'intraocular drug injection device mounting assembly 100' installed on the patient's skull 10b (Fig. 14), and then the syringe needle 181 (FIG. 15 and FIG. 16). FIG. 15 and FIG. 16 show the process of injecting the stem cells 185 into the catheter 140.

14, after the chamber 130 is fixed to the skull 10b by the fixing bolt 132b, the guiding hub 110 is rotated to disengage from the chamber 130, and the chamber 130 ). At this time, the guide 120 is also removed together.

15 and 16, the needle 181 of the syringe 180 is inserted into the chamber 130 and the catheter 140, and then the syringe 180 is operated to move the stem cells 185 into the lesion Lt; / RTI > If the needle 181 of the syringe 180 is immediately pulled out from the catheter 140, there is a risk that the brain tissue is sucked out due to the negative pressure in the brain. Therefore, it is preferable to slowly inject the saline solution while withdrawing the syringe needle. In FIG. 16, reference numeral 182 denotes a saline supply pipe connected to the syringe 180.

17 shows a state in which the barrier disc 170 and the upper cap 160 are filled in the chamber 130 after the primary stem cell administration is completed in the patient's brain and FIG. The skin 13 is completely covered with the drug infusion device 101 in the brain.

15 and 16, it is described that the stem cell 185 is administered while the syringe 180 is inserted immediately after the guiding hub 110 is taken out of the chamber 130. Alternatively, the guiding hub 185 It is also possible to insert the syringe needle 181 after inserting the silicon disc 170 and the upper cap 160 as shown in FIG. Since the silicon dioxide blocking disc 170 can pass through the injection needle and the through hole 165 is formed at the center of the upper cap 160 as well, the upper cap 160 is completely covered, 181) can be inserted. Since the perforated disc 170 of the silicone material is closed again after the syringe needle 181 is removed, the stem cell administration operation is performed after the closure disc 170 and the upper cap 160 are installed as shown in FIG. It is also acceptable.

 19 shows a process of inserting a syringe needle 181 into an intra-cerebral drug injector 101 installed in a head of a patient when the stem cells are repeatedly administered to the brain of a patient with Alzheimer's dementia, The stem cells 185 in the syringe 180 are administered to the lesion in the patient's brain.

Stem cells become less effective after 3 to 6 months after the first administration of stem cells, so it is necessary to repeatedly administer stem cells. If the intra-cerebral drug infusion device 101 is not installed, the patient's head is punctured and the syringe is inserted. However, when the intra-cerebral drug infusion device 101 is installed as in the present invention, Only the skin 13 covering the upper portion of the upper cap 160 is slightly cut and the syringe needle 181 is inserted into the through hole 160 of the upper cap 160. The syringe needle 181 may be inserted into the catheter 140 through the silicone-made barrier disc 170 and may reach the location of the lesion. When the syringe needle 181 is withdrawn immediately after the stem cell 185 is withdrawn, there is a danger that the brain tissue may be sucked out due to the negative pressure in the brain, so that the needle 181 is slowly withdrawn and the saline solution is injected desirable.

21 and 22 show a navigation system for brain surgery displaying the position of the guide 120 in real time on the image data of a magnetic resonance imaging (MRI) apparatus 120 ', wherein FIG. FIG. 22 is an image when the guide 120 is inserted into the upper wedge lobe 12c of the patient's brain.

In the MRI image screen of FIG. 21 (a), the guide 120 is inserted from the back of the patient's head, and the same state is displayed on the MRI image screens of FIG. 21 (b). FIG. 21 (b) is a photograph of the monitor of the navigation system for brain surgery. In FIG. 21, reference numeral 30 denotes an apparatus control unit, and 31 denotes operation buttons.

23 and 24 show a modification of the coupling structure of the guiding hub 110 and the guide 120 according to the second embodiment of the present invention. 23 is a perspective view of the guiding hub 110 and the guide 120, and FIG. 24 is a cross-sectional view of the guiding hub 110 and the guide 120 in a combined state.

23, a bolt fastening hole 117 is formed in the grip 112 of the guiding hub 110. The bolt fastening hole 117 is formed in the guide hole 115 (See FIG. 24). The fastening bolt 117a may be fastened to the bolt fastening hole 117 and the fastening bolt 117a may be fastened to the bolt fastening hole 117 to tighten the guide 120, The position is fixed.

23 and 24, it is not necessary to process the threaded portion on the distal portion 122 'of the guide 120, so that it is possible to prevent the guide 120, There is an advantage that the manufacturing cost of the semiconductor device can be reduced.

As described above, the intra-cerebral drug infusion device and the method of the present invention for injecting a drug into the brain according to the present invention can be applied to an intra-cerebral lesion requiring intermittent repetitive drug administration or cell tissue transplantation, There is an advantage of constructing a system capable of intermittent and repeated microinjection only by long-term maintenance by one operation without repeated operation.

The specific advantages of the present invention will be described. However, it is possible to eliminate the side effect of the patient and the risk of the surgery due to the repetitive brain surgery, and to express the maximal effect by injecting the minimal drug / cell directly into the lesion, There is an advantage that the side effect of the patient can be minimized.

In addition, although many methods are currently being tried to administer drugs or reconstructed cells into the brain, they suffer difficulties in the passage of the brain blood barrier. There is no difficulty in passing through the blood vessel barrier, and there is an advantage that the therapeutic effect can be maximized by directly administering the drug or cell.

In addition, the present invention has an advantage of being able to collect the cell tissue of a brain lesion to which drug and stem cells are administered through accurate clinical progress and monitoring of the lesion.

Meanwhile, FIG. 25 shows the structure of a chamber 200 used in a drug infusion device, which is a third embodiment of the present invention.

Unlike the above-described chamber 130, the chamber 200 is not provided with the catheter fixing cap 150 and the upper cap 160, but has a chamber body 231 and a cover member 241. Since the chamber 200 is similar in some components to the chamber 130, only differences between the chamber 200 and the chamber 130 will be described below.

The chamber body 231 is a member of a circular tube, and both end portions thereof are opened by forming a second through hole 232 and a third through hole 234, respectively.

The chamber body 231 has an internal space 135 that passes from the second through hole 232 to the third through hole 234.

On the inner circumferential surface of the second through hole 232 of the chamber body 231, a female threaded portion 233 is formed.

The chamber body 231 includes an arm portion 132 protruding outwardly from the periphery of the third through-hole 234.

The third through hole 234 is formed with a separation preventing portion 235 for preventing the blocking disk 170 that can be accommodated in the inner space 135 of the chamber body 231 from separating away .

In the present embodiment, the release preventing portion 235 protrudes inward toward the center axis CL of the third through hole 234 by a predetermined length, and the periphery of the third through hole 234 And are formed in a ring shape.

The cover member 241 is a tapered tube member configured to close the second through hole 232 of the chamber body 231. The inner space is an inner space 136 of a cone type.

A third protrusion 245 is formed in the general part of the cover member 241 so that the third protrusion 245 is inserted into the distal end portion 142 of the catheter 140, .

A first through hole 137 communicating with the inner space 135 is formed at a distal end of the third protrusion 245.

At the middle portion of the third protrusion 245, a depression 246 is formed along the periphery.

Between the groove portion 246 and the cover member 241, a locking protrusion 247 protruding in the radial direction of the central axis CL is formed.

The grooves 246 and the locking protrusions 247 may be formed such that the catheter 140 and the third protrusion 245 are not separated from each other when the catheter 140 and the third protrusion 245 are coupled And performs a function of increasing the bonding force.

A circular tubular insertion portion 242 is formed at the other end of the cover member 241 and protruded along a center axis CL by a predetermined length.

A threaded portion 243 is formed on the outer circumferential surface of the insertion portion 242 so as to be detachably engaged with the female threaded portion 233 of the chamber body 231.

Between the cover member 241 and the insertion portion 242, a wing portion 244 is formed along the circumferential direction of the insertion portion 242.

The wing portion 244 is an annular member protruding by a predetermined length in the radial direction of the insertion portion 242. When the cover member 241 is coupled to the chamber body 231, And performs a kind of stopper function for limiting the insertion depth between the main body 231 and the cover member 241. [

The blocking disc 170 is inserted into the inner space 135 of the chamber 200 and blocks the third through-hole 234 of the chamber 200.

In the present embodiment, the intra-cerebral drug infusion device includes a needle guide tube 250, which is a circular tube member having a long elongated shape, and a needle (not shown) of the needle 180 181 can be inserted and has an outer diameter that can be inserted into the catheter 140. [

One end of the needle guide tube 250 is inserted into the inner space 135 of the chambers 130 and 200 through the blocking disk 170 so that the distal end 142 of the catheter 140 Depth.

Since the needle guide tube 250 should not be bent when inserted through the blocking disc 170, it is preferable that the needle guide tube 250 is made of a material having high strength.

An example of a method of using a drug injection device in the brain using the chamber 200 shown in FIG. 25 is as follows.

First, the skull 10b of a patient (P) having a brain degenerative disease including Alzheimer's type dementia is punctured to make a hole. (Step 1)

The catheter 140 having the guide 120 inserted therein is inserted into the parenchyma 15 of the patient P through the hole formed in the skull 10b so that the proximal end 141 of the catheter 140 is inserted into the patient (P) to the lesion 12 (second step)

After the proximal end 141 of the catheter 140 reaches the lesion 12 of the patient P, the guide 120 is pulled out from the catheter 140 to be separated and removed. (Third Step)

The third protrusions 245 of the chamber 200 are then inserted into the inner space of the catheter 140 and connected to one another so that the outer surface of the distal end 142 of the catheter 140, The third protrusion 245 and the catheter 140 are fixed so that they are not separated from each other and the arm 200 is fixed to the patient's skull 10b by using the arm 132. Step 4)

31, one end of the needle guide tube 250 is connected to the inner space 135 of the chamber 200 through the third through-hole 234 formed in the chamber body 231 . At this time, one end of the needle guide pipe 250 is in communication with the inner space 135 of the chamber 200 through the blocking disk 170. One end of the needle guide tube 250 may be positioned in the interior 135 or 136 of the chamber 200 or may be inserted into the distal end 142 of the catheter 140 at a predetermined depth. (Step 5)

The needle 181 of the syringe 180 is inserted into the inner space 135 of the chamber 200 by inserting the needle 181 of the syringe 180 into the other end of the needle guide tube 250. [ ). At this time, the needle 181 of the syringe 180 is preferably not inserted deep enough to reach the lesion 12 through the inside of the catheter 140. (Step 6)

Finally, the operation is completed by operating the syringe 180 to administer the stem cell 185 or a drug for treating a brain disease to the lesion 12, and then withdrawing and removing the syringe 180. (Step 7)

Meanwhile, when the chamber 200 is used to administer the stem cell or brain disease treatment drug to the brain of the patient P again, the above-mentioned fifth step may be repeatedly performed.

The drug infusion device using the chamber 200 described above is opened by forming the second through hole 232 and the third through hole 234 at both ends thereof and the second through hole 232 from the second through hole 232, A chamber main body 231 having an internal space 135 in the form of reaching the third through hole 234 and a member formed to close the second through hole 232 of the chamber main body 231, A cover member (241) detachably coupled to the through hole (232) and having a third protrusion (245) extending in a long direction at one end; And a blocking disk 170 inserted in the inner space 135 of the chamber 200 to block the third through hole 234 of the chamber 200. The chamber body 231 and the cover member 241 are combined with each other, it is easy to mount and replace the blocking disc 170.

Unlike the above-described chamber 130, the drug injection device using the chamber 200 does not include the catheter fixing cap 150 and the upper cap 160, so that the entire structure is simple, And there is an advantage that the operation is easy.

In addition, the in-brain drug infusion device using the chamber 200 includes a cover member 241 having a third protrusion 245 having a long elongated shape at one end, a thin and long tubular member, And a catheter 140 whose distal end 142 is fitted in and engaged with the third projection 245 of the chamber 200 so that the catheter 140 is inserted through the hole in the skull 10b, The catheter 140 may be inserted into the parenchyma 15 of the catheter 140 and then the third projection 245 may be coupled to the distal end 142 of the catheter 140 without using the catheter- There is an advantage.

The intravenous drug infusion device using the chamber 200 is a tubular member into which the needle 181 of the syringe 180 can be inserted and is inserted into the inner space 135 of the chamber 130 or 200 In the process of inserting the needle 181 of the syringe 180 into the interior of the chamber 200 or into the interior of the catheter 140 because the syringe 180 includes a needle guide tube 250, 180 are bent and do not tear or damage the catheter 140.

In addition, a drug insertion device using the chamber 200 is provided with a perforation disc 170 which can be accommodated in the inner space 135 of the chamber body 231 in the third through-hole 234, The blocking discs 170 can be fixed without the upper cap 160. In this case, as shown in FIG.

In the in-brain drug infusion device using the chamber 200, the release preventing portion 235 is protruded inward by a predetermined length toward the center axis CL of the third through hole 234, The perforation disc 170 is uniformly pressurized and can be prevented from being detached from the chamber 200 because the perforated disc 170 is formed in an annular shape along the circumference of the third through hole 234. [

31, after the needle guide tube 250 is inserted into the chamber 200, the needle 181 of the syringe 180 is inserted into the needle guide tube 250 The needle 181 of the syringe 180 is first inserted into the other end of the needle guide tube 250 as shown in Figure 32. In this state, It is also possible to insert one end into the chamber 200.

Until now, there has been no internationally available apparatus for administering stem cells into the brain and for treating Alzheimer's disease using the same. The inventor of the present invention has developed a drug injection apparatus for intracerebral injection for repeated administration of a stem cell or brain disease therapeutic drug in the brain . It is anticipated that the present invention will be the first in the world to establish a new field of stem cell transplantation and microdissection in the treatment of Alzheimer's disease. In particular, repeated administration of stem cells at precise locations in the brain has rarely been reported worldwide, and the present invention has established a method of repeatedly administering stem cells to the correct positions in the brain, And it is expected that it will be able to acquire world-exclusive proprietary technology for stem cell administration system, and it will be an opportunity to secure the treatment and academic development and international status of Alzheimer's disease.

The intra-cerebral drug injection device according to the present invention is basically a device for repeatedly administering a stem cell to a parenchyma region of a subject suffering from Alzheimer's disease. However, it can expand the target disease by variously controlling the parenchyma region , And may also be used as a preventive measure in early disease stages. Further, since the present invention is directed to the brain parenchyma region, it can be used sufficiently as a device for stem cell transplantation even in the case of a disease which is not a disease.

1: Navigation system 2: Main body
2a: Navigator Processor 3: Monitor
3a: Support part 4: Sensor part
5: connection support 6: MRI imaging
7: Probe 7a, 8: Reflector
9: Toe fixation device 10: Tofu (head)
10a: Tofu MRI image 10b: Skull
11: Scanner 11a: Scanning light
12: lesion location 12a: left hippocampus
12b: right hippocampus 12c: right wedge lobe (precuneus)
13: skin 13a: incision
15: Parenchyma 20: Practical equipment
21: gripping unit 30:
31: Operation buttons 60: MRI device
100: assembly for intravenous drug infusion device
101: Brain drug injection device 110: guiding hub
111: body portion 111a:
111b: engagement jaw 112:
113: side surface 115: guide engaging hole
115a: female thread portion 116: proximal face
117: bolt fastening ball 117a: fastening bolt
120: guide 120 ': indication of guide position
121: distal end 122:
122 ': distal portion 130: chamber
131: bottom surface 132: arm portion
132a: Bolt hole 132b: Fixing bolt
133: first protrusion 133a:
134: second protrusion 135: inner space
135a: inner protrusion 136: inner cone type space
137: first through hole 138: protrusion
140: catheter 141: proximal end
142: Distal end 143: Inner space of the catheter
150: catheter fixing cap 151: through hole
152: female thread portion 153: inner pressing wall surface
154: inlet hole 156: tapered portion
160: upper cap 161a:
161b: latching jaw 162: proximal face
163: side 165: through hole
166: Circle surface 167: Socket for rotation
170: Blocking disk 180: Syringe
181: Syringe needle 182: Saline supply tube
185: stem cell 200: chamber
231: chamber body 232: second through hole
233: Female thread portion 234: Third through hole
235: separation preventing portion 241: cover member
242: insertion portion 243: male thread portion
244: wing portion 245: third projection
246: groove portion 247:
250: Needle guide tube CL: Center axis
P: patient

Claims (25)

A chamber 130 having one surface open and a concave internal space 135 and a bottom surface 131a formed with a protrusion 138;
A catheter 140 having an elongate tubular member, the distal end 142 of the catheter fitting into a projection 138 of the chamber 130;
A catheter securing cap 150 coupled to the projection 138 of the chamber 130 to secure the distal end 142 of the catheter 140 to the protrusion 138 of the chamber 130;
A blocking disk (170) inserted into the inner space (135) of the chamber (130) to block the open surface of the chamber (130); And
And an upper cap 160 fitted in the inner space 135 of the chamber 130 and positioned above the blocking disk 170,
Wherein the therapeutic agent can be used for administering at least one of substances including a stem cell and a therapeutic agent for brain diseases to a brain area. The catheter of claim 1, further comprising a syringe (180) containing stem cells (185) or a therapeutic agent for a brain disease, wherein the needle (181) of the syringe (180) Wherein the drug is injected into the brain. [3] The apparatus of claim 1, wherein the protrusion (138) of the chamber (130) comprises: a first protrusion (133) protruding from the bottom surface (131a) in a cylindrical shape; And a second protrusion (134) extending further from the first protrusion (133)
A male screw portion 133a is formed around the first projecting portion 133,
Wherein the second protrusion (134) has a cone shape and a first through hole (137) is formed along a center axis (CL) thereof. The catheter according to claim 1, wherein the catheter securing cap (150)
A female screw portion 152 formed on an inner wall surface;
A through hole 151 having a smaller diameter than the female thread 152; And
And an internal compression wall surface (153) having a diameter gradually narrowed between the female threaded portion (152) and the through hole (151). The apparatus of claim 1, wherein the chamber further includes an arm portion protruding outwardly from the periphery of the open portion, wherein the arm portion includes a bolt hole Wherein the medicament is injected into the brain. [2] The apparatus according to claim 1, wherein a plurality of inner protrusions (135a) protrude from an inner wall surface of the chamber (130)
The upper cap 160 is a coin shaped member having a through hole 165 formed at the center thereof and the inner protrusions 135a of the chamber 130 can be inserted into the side surface 163 of the upper cap 160, Wherein a plurality of latching grooves (161a) are formed. The intravenous drug injection device according to claim 6, wherein the latching grooves (161a) of the upper cap (160) are formed in an L shape when viewed from the side of the upper cap (160). The capsule endoscope according to claim 1 or 6, wherein a plurality of rotating sockets (167) are recessed from the surface of the upper cap (160) on a distal surface (166) of the upper cap (160) Injection device. The intravenous drug injection device according to claim 1, wherein the blocking disk (170) is made of at least one of synthetic resin materials including silicone, and the syringe needle can pass through. A chamber 130 having one surface open and a concave internal space 135 and a bottom surface 131a formed with a protrusion 138;
A catheter 140 having an elongate tubular member, the distal end 142 of the catheter fitting into a projection 138 of the chamber 130;
A catheter securing cap 150 coupled to the projection 138 of the chamber 130 to secure the distal end 142 of the catheter 140 to the protrusion 138 of the chamber 130;
And a grip portion 112 extended from the distal portion of the body portion 111 and inserted into and fixed to the inner space 135 of the chamber, A guiding hub 110 having a through hole 115 formed therethrough; And
And a guide (120) having one end inserted and fixed to the guide coupling hole (115) of the guiding hub (110). 11. The apparatus of claim 10, wherein a plurality of inner protrusions (135a) protrude from an inner wall surface of the chamber (130)
The body 113 of the guiding hub 110 has a cylindrical shape and a plurality of inner protrusions 135a of the chamber 130 are inserted into a side surface 113 of the body 111, (111a) are formed on the outer circumferential surface of the medicament-injecting device. The assembly as claimed in claim 11, wherein the latching grooves (111a) of the guide hub (110) are formed in an L shape when viewed from the side of the body part (111). The guiding hole (115) of the guiding hub (110) is formed with a female threaded portion (115a), and a distal end of the guide (115) 122) is formed on the inner surface of the medicament body. The bolt fastener according to claim 10, wherein a bolt fastening hole (117) is formed in the grip part (112), and the bolt fastening hole (117) is in communication with the guide fastening hole (115) And the fastening bolt (117a) can be fastened. (a) a first step of perforating the skull 10b of a patient P having a brain degenerative disease including Alzheimer's type dementia and piercing it;
(b) inserting the 'intraocular drug-injecting device mounting assembly' 100 into the parenchyma 15 of the patient P through the hole to allow the proximal end of the catheter 140 to reach the lesion 12 of the patient P And then fixing the chamber 130 of the assembly 100 to the patient's skull 10b;
(c) separating and removing the guiding hub 110 from the chamber 130, thereby removing the guide 120 as well;
(d) By inserting the needle 181 of the syringe 180 containing the stem cell 185 or the cerebral disease therapeutic drug into the chamber 130, the syringe needle 181 is inserted into the inside of the catheter 140 To reach the lesion (12) through a fourth step;
(e) activating the syringe 180 to administer the stem cell 185 or a drug for treating brain diseases to the lesion 12, and then removing the syringe 180; And
(f) a sixth step of disposing a blocking disc 170 made of silicon in the chamber 130 and then coupling the upper cap 160 to the chamber 130,
The 'intra-cerebral drug infusion device mounting assembly 100' includes a chamber 130 having an inner space 135 opened on one side and a concave shape and a protrusion 138 formed on a bottom surface 131a, an elongated tubular member A distal end 142 of the catheter 140 is coupled to a projection 138 of the chamber 130 to allow the proximal end 142 of the catheter 140 to fit into the projection 138 of the chamber 130, A catheter fixing cap 150 for fixing the catheter 130 to the protrusion 138 of the chamber 130, a body 111 inserted and fixed in the inner space 135 of the chamber, A guiding hub 110 having a grasping portion 112 formed on the guiding hub 110 and extending along the center axis CL of the guiding hub 110, And a guide (120) inserted into and fixed to the guide coupling hole (115) of the brain disease therapeutic agent Methods of administration. 16. The method according to claim 15, wherein, when the stem cell or the brain disease treating drug is repeatedly administered to the brain of the patient (P)
(g) The needle 181 of the syringe 180 containing the stem cell 185 or the cerebral disease therapeutic drug is inserted into the catheter 140 through the passage hole 165 formed at the center of the upper cap 160. [ The needle 181 of the syringe passes through the blocking disc 170. The needle 181 of the syringe is inserted into the inner space 143 of the syringe so that the needle 181 of the syringe reaches the lesion 12. And
(h) operating the syringe 180 to administer the stem cell 185 or a drug for treating a brain disease to the lesion 12, and then removing the syringe 180. [ Intracerebral administration of a disease treating drug. The second through hole 232 and the third through hole 234 are opened to form an inner space 135 extending from the second through hole 232 to the third through hole 234 And a second through hole 232 of the chamber body 231. The second through hole 232 is detachably coupled to the second through hole 232, And a cover member (241) having a third protrusion (245) of elongated shape;
A blocking disk 170 inserted into the inner space 135 of the chamber 200 to block the third through-hole 234 of the chamber 200;
And a catheter 140 having an elongate tubular member with a distal end 142 of the elongated tubular member fitted into the third projection 245 of the chamber 200,
Wherein the therapeutic agent can be used for administering at least one of substances including a stem cell and a therapeutic agent for brain diseases to a brain area. 18. The method according to claim 17, wherein the blocking disk (170) is made of at least one of synthetic resin materials including silicone, and a pointed object such as a syringe needle can pass through and the pointed object And the drug can be restored to its original shape even if it is removed after it is removed. The syringe according to any one of claims 1 to 17, further comprising a syringe (180) containing stem cells (185) or a cerebral disease therapeutic drug, wherein a tubular member into which the needle (181) And a needle guide tube (250) into which one end of the needle guide tube (250) can be inserted into the inner space (135) of the chamber (130, 200). 18. The apparatus of claim 17, wherein the chamber body (231) further comprises an arm portion (132) protruding outwardly from the periphery of the third through hole (234) Wherein a hole (132a) is formed in the inner wall of the brain. 18. The apparatus according to claim 17, wherein a female screw portion (233) is formed on an inner circumferential surface of the second through hole (232) of the chamber body (231)
And the other end of the cover member (241) is provided with a male threaded portion (243) detachably coupled to the female threaded portion (233). 18. The method of claim 17,
The third through hole 234 is formed with a release preventing portion 235 for preventing the blocking disk 170 that can be accommodated in the inner space 135 of the chamber body 231 from separating away Intra-brain drug injection device characterized. 23. The method of claim 22,
The separation preventing portion 235 is protruded inward by a predetermined length inward toward the center axis CL of the third through hole 234 and is formed in an annular shape along the periphery of the third through hole 234 Wherein the medicament is injected into the brain. 18. The method of claim 17,
And a wing portion 244 formed around the outer circumferential surface of the cover member 241 and protruding from the outer circumferential surface of the cover member 241 by a predetermined length,
Characterized in that the wing portion (244) can limit the coupling depth between the chamber body (231) and the cover member (241) when the cover member (241) is coupled to the chamber body (231) Drug injection device. (a) a first step of perforating the skull 10b of a patient P having a brain degenerative disease including Alzheimer's type dementia and piercing it;
(b) The catheter 140 with the guide 120 inserted through the hole is inserted into the parenchyma 15 of the patient P so that the proximal end of the catheter 140 reaches the lesion 12 of the patient P ;
(c) a third step of withdrawing and removing the guide 120 from the catheter 140;
(d) connecting the chamber 200 with the catheter 140, and then fixing the chamber 200 to the patient's skull 10b;
(e) One end of the needle guide tube 250 is inserted into the inner space 135 of the chamber 200 through the third through-hole 234 formed in the chamber body 231, A fifth step in which one end of the pipe 250 penetrates the blocking disk 170 and communicates with the inner space 135 of the chamber 200;
(f) The needle 181 of the syringe 180 is inserted into the other end of the needle guide tube 250, so that the needle 181 of the syringe 180 and the inner space 135 of the chamber 200 A sixth step of communicating with each other;
(g) a seventh step of operating the syringe 180 to administer the stem cell 185 or a drug for treating a brain disease to the lesion 12, and then removing the syringe 180,
The chamber 200 is opened at both ends by forming a second through hole 232 and a third through hole 234 from the second through hole 232 to the third through hole 234 And a second through hole 232 of the chamber main body 231. The second through hole 232 is detachably attachable to the second through hole 232, And a cover member (241) coupled at one end with a third protrusion (245) of elongated shape; A catheter 140 having an elongate tubular member, the distal end 142 of the elongated member 142 being inserted into the third projection 245 of the chamber 200; A guide 120 that is a long rod member that can be fitted into the internal space of the catheter 140; A blocking disk 170 inserted into the inner space 135 of the chamber 200 to block the third through-hole 234 of the chamber 200; And a needle guide tube 250 into which the needle 181 of the syringe 180 can be inserted and into which one end of the needle can be inserted into the internal space 135 of the chamber 200 Or a pharmaceutically acceptable salt thereof.

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