KR20200086879A - Drug injector for treating dementia - Google Patents

Drug injector for treating dementia Download PDF

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Publication number
KR20200086879A
KR20200086879A KR1020190003209A KR20190003209A KR20200086879A KR 20200086879 A KR20200086879 A KR 20200086879A KR 1020190003209 A KR1020190003209 A KR 1020190003209A KR 20190003209 A KR20190003209 A KR 20190003209A KR 20200086879 A KR20200086879 A KR 20200086879A
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drug injection
main body
diaphragm
treating dementia
drug
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KR1020190003209A
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Korean (ko)
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이부락
성지원
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(주) 서한케어
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/025—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body through bones or teeth, e.g. through the skull
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/027—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body having a particular valve, seal or septum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
    • A61M2039/0294—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body having a specific shape matching the shape of a tool to be inserted therein, e.g. for easy introduction, for sealing purposes, guide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A drug injection device for treating dementia is disclosed. The disclosed drug injection device for treating dementia includes: a main body having an internal drug injection port formed therein and directly fixed to the skull of an animal; a tube positioned on a lower part of the main body and entering the brain and inducing drug injection of an injection needle in a target direction; a drug injection diaphragm which is located inside the main body, is provided to seal the drug injection port of a main body part, and into which a syringe needle for injecting drugs is inserted; and a sealing part positioned on an upper part of the drug injection diaphragm and sealing and fixing the main body.

Description

치매치료용 약물 주입 장치{DRUG INJECTOR FOR TREATING DEMENTIA}DRUG INJECTOR FOR TREATING DEMENTIA

본 발명은 치매치료용 약물 주입 장치에 관한 것으로서, 특히 알츠하이머병을 앓고 있는 중소형 동물 치료를 위한 구조의 단순화 및 소형화가 가능한 치매치료용 약물 주입 장치에 관한 것이다.The present invention relates to a drug injection device for the treatment of dementia, and more particularly, to a drug injection device for the treatment of dementia capable of simplifying and miniaturizing a structure for treating small and medium animals suffering from Alzheimer's disease.

알츠하이머 치매는 다양한 병인기전에 의해 발병하고 있으며 특히 뇌 속에 축척된 베타 아밀로이드 단백질이 신경독성을 유발하여 신경세포사(neuronal cell death)를 유도하므로 결국 뇌가 파괴되고 모든 정신활동이 저하되는 질환이다. 사람뿐만 아니라 동물들에게도 이 질환을 가진 개체수가 급격히 늘어가고 있으나 근본적인 치료약이 없어 많은 동물들이 고통을 겪고 있다. 따라서 최근 세계적으로 인체에서 유래한 다양한 줄기세포를 이용하여 알츠하이머병을 치료하고자 하는 비임상연구 및 임상연구가 활발히 진행되고 있다. Alzheimer's dementia is caused by various etiological mechanisms, and in particular, beta amyloid protein accumulated in the brain induces neurotoxicity and induces neuronal cell death, which eventually destroys the brain and reduces all mental activity. Not only humans but also animals are rapidly increasing the number of people with this disease, but many animals suffer because there is no underlying treatment. Therefore, in recent years, non-clinical and clinical studies have been actively conducted to treat Alzheimer's disease using various stem cells derived from the human body.

그러나 줄기세포를 이용하여 알츠하이머병 치료제를 개발하는 일에 가장 큰 장벽은 투여경로이다. 뇌를 타깃으로 하는 약물은 반드시 뇌혈관장벽(Blood-Brain Barrier, BBB)을 통과해야 하는 어려움이 있다. 줄기세포의 경우도 마찬가지로 뇌로 효과적으로 전달되어야 기능을 발휘할 수 있다. 줄기세포의 전달 효율을 가장 최우선으로 한다면 뇌수술을 통한 줄기세포의 직접이식이 가장 좋은 방법이지만 환자가 신경외과수술을 받아야하는 위험부담이 있고 반복 투여가 요구될 시 현실적으로 한계성이 있다.However, the biggest barrier to the development of treatments for Alzheimer's disease using stem cells is the administration route. Drugs targeted at the brain must pass through the blood-brain barrier (BBB). In the case of stem cells, they must be effectively delivered to the brain to function. If the transfer efficiency of stem cells is the highest priority, direct transplantation of stem cells through brain surgery is the best method, but there is a risk that patients need to undergo neurosurgery surgery and there is a practical limitation when repeated administration is required.

대한민국 공개특허공보 제10-2014-0137308호(2014.12.02.)Republic of Korea Patent Publication No. 10-2014-0137308 (2014.12.02.) 대한민국 등록특허공보 제10-1100526호(2011.12.22.)Republic of Korea Registered Patent Publication No. 10-1100526 (Dec. 22, 2011) 미국 공개특허공보 제2002-0138068호(2014.12.02.)U.S. Patent Publication No. 2002-0138068 (2014.12.02.)

본 발명은 상기한 바와 같은 점을 감안하여 창안된 것으로서, 구조가 단순화 및 소형화된 치매치료용 약물 주입 장치를 제공하는 데 그 목적이 있다. The present invention has been devised in view of the above points, and has an object to provide a drug injection device for the treatment of dementia with a simplified and miniaturized structure.

상기한 목적을 달성하기 위한 본 발명에 따른 치매치료용 약물 주입 장치는 내부 약물주입구인 홀이 형성되어 동물의 두개골에 직접 고정시키기는 본체와; 본체 하부에 위치하고 뇌내로 들어가 타겟방향으로 주사바늘의 약물주입을 유도하는 튜브와; 본체 내부에 위치하고, 본체부의 약물주입구를 밀폐하도록 구비되며, 약물을 주사하기 위한 주사기 바늘이 삽입되는 약물주입격막; 및 약물주입격막 상부에 위치하고, 본체를 밀폐 고정시키는 밀폐부를 포함할 수 있다.The drug injection device for the treatment of dementia according to the present invention for achieving the above object is formed with a hole, which is an internal drug injection port, and is directly fixed to the animal's skull; A tube which is located under the body and enters the brain to induce drug injection of the needle in the target direction; A drug injection diaphragm located inside the main body, provided to seal the drug injection port of the main body, and into which a syringe needle for injecting the drug is inserted; And it is located on the drug injection diaphragm, it may include a sealing portion for sealing and fixing the body.

본 발명에 따른 치매치료용 약물 주입 장치는 구조의 단순화 및 소형화함으로써, 중소형 동물 뇌내에 장기간 이식된 상태에서 반복 투여시 발생되는 부작용을 감소시키는 효과가 있다. The drug injection device for the treatment of dementia according to the present invention has an effect of reducing side effects caused by repeated administration in a state transplanted into a medium-sized animal brain for a long time by simplifying and miniaturizing the structure.

도 1은 본 발명의 실시예에 따른 치매치료용 약물 주입 장치를 개략적으로 보인 사시도.
도 2는 도 1의 실시예에 따른 치매치료용 약물 주입 장치의 정면도.
도 3은 도 1의 실시예에 따른 치매치료용 약물 주입 장치의 좌측면도.
도 4는 도 1의 실시예에 따른 치매치료용 약물 주입 장치의 평면도.
도 5는 도 4의 A-A선 단면도.1 is a perspective view schematically showing a drug injection device for treating dementia according to an embodiment of the present invention.
Figure 2 is a front view of the drug injection device for treating dementia according to the embodiment of Figure 1;
Figure 3 is a left side view of the drug injection device for treating dementia according to the embodiment of Figure 1;
Figure 4 is a plan view of a drug injection device for treating dementia according to the embodiment of Figure 1;
Figure 5 is a cross-sectional view taken along line AA of Figure 4;

이하, 첨부된 도면들을 참조하여 본 발명의 실시예에 따른 치매치료용 약물 주입 장치를 상세하게 설명하기로 한다. 여기서, 첨부된 도면들은 기술의 구성 및 작용에 대한 설명과 이해의 편의 및 명확성을 위해 일부분을 과장하거나 간략화하여 도시한 것으로서, 각 구성요소가 실제의 크기와 정확하게 일치하는 것은 아니다.Hereinafter, a drug injection device for treating dementia according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. Here, the accompanying drawings are exaggerated or simplified for a convenience and clarity of description and understanding of the structure and operation of the technology, and each component does not exactly match the actual size.

도 1 내지 도 5를 참조하면, 치매치료용 약물 주입 장치는 동물의 두개골에 설치된 본체(10), 뇌내로 주입된 튜브(30), 주사바늘이 삽입되는 약물주입격막(50) 및 본체(10) 상부에 덮여져 밀폐하는 밀폐부(70)를 포함할 수 있다.1 to 5, the drug injection device for the treatment of dementia is a body 10 installed in the skull of an animal, a tube 30 injected into the brain, a drug injection diaphragm 50 and a body 10 into which an injection needle is inserted ) It may include a sealing portion 70 that is covered and sealed on the upper portion.

여기서 본체(10)는 본체내부 약물주입구인 홀이 형성되어 동물의 두개골에 직접 고정시킬 수 있다.Here, the main body 10 is formed with a hole, which is a drug injection hole inside the main body, and can be directly fixed to the skull of the animal.

튜브(30)는 본체 하부에 위치하고 뇌내로 들어가 타겟방향으로 주사바늘의 약물주입을 유도할 수 있다. 또한, 금속 및 합성소재로 이루어져 긴 관의 형태를 가질 수 있다.The tube 30 is located under the body and can enter the brain to induce drug injection of the needle in the target direction. In addition, it can be made of metal and synthetic materials to have a long tube shape.

약물주입격막(50)은 실리콘으로 제조되며 본체(10) 내부에 위치하고, 본체(10)의 약물주입구를 밀폐하도록 구비되며, 약물을 주사하기 위한 주사바늘이 삽입될 수 있다.The drug injection diaphragm 50 is made of silicone and is located inside the body 10, and is provided to seal the drug injection port of the body 10, and an injection needle for injecting the drug may be inserted.

밀폐부(70)는 약물주입격막(50) 상부에 위치하고, 상기 본체를 밀폐 고정시킬 수 있다.The sealing part 70 is located above the drug injection diaphragm 50, and the main body can be hermetically fixed.

상기한 실시예들은 예시적인 것에 불과한 것으로, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 사람이라면 이로부터 다양한 변형 및 균등한 타 실시예가 가능하다. 따라서 본 발명의 진정한 기술적 보호범위는 청구범위에 기재된 발명의 기술적 사상에 의해 정해져야만 할 것이다.The above-described embodiments are merely exemplary, and various modifications and equivalent other embodiments are possible from those skilled in the art to which the present invention pertains. Therefore, the true technical protection scope of the present invention should be determined by the technical spirit of the invention described in the claims.

1: 치매치료용 약물 주입 장치
10: 본체 30: 튜브
50: 약물주입격막 70: 밀폐부1: Drug injection device for the treatment of dementia
10: body 30: tube
50: drug injection diaphragm 70: sealing portion

Claims (1)

내부 약물주입구인 홀이 형성되어 동물의 두개골에 직접 고정시키기는 본체와;
상기 본체 하부에 위치하고 뇌내로 들어가 타겟방향으로 주사바늘의 약물주입을 유도하는 튜브와;
상기 본체 내부에 위치하고, 상기 본체부의 약물주입구를 밀폐하도록 구비되며, 약물을 주사하기 위한 주사기 바늘이 삽입되는 약물주입격막; 및
상기 약물주입격막 상부에 위치하고, 상기 본체를 밀폐 고정시키는 밀폐부를 포함하는 치매치료용 약물 주입 장치.A body which is formed with an internal drug injection hole and is directly fixed to the animal's skull;
A tube which is located under the body and enters the brain to induce drug injection of the needle in a target direction;
A drug injection diaphragm located inside the main body, provided to close the drug injection port of the main body, and into which a syringe needle for injecting drugs is inserted; And
A drug injection device for treatment of dementia, which is located on the drug injection diaphragm and includes a sealing part for sealingly fixing the main body.
KR1020190003209A 2019-01-10 2019-01-10 Drug injector for treating dementia KR20200086879A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020138068A1 (en) 2000-12-14 2002-09-26 Watson David A. Implantable refillable and ported controlled release drug delivery device
KR101100526B1 (en) 2009-06-29 2011-12-30 국립암센터 Medicinal fluid injection port
KR20140137308A (en) 2013-05-22 2014-12-02 사회복지법인 삼성생명공익재단 Intracerebral drug injection device, the assembly for installing the injection device, and a method for delivering cerebropathy treatment drugs into the human brain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020138068A1 (en) 2000-12-14 2002-09-26 Watson David A. Implantable refillable and ported controlled release drug delivery device
KR101100526B1 (en) 2009-06-29 2011-12-30 국립암센터 Medicinal fluid injection port
KR20140137308A (en) 2013-05-22 2014-12-02 사회복지법인 삼성생명공익재단 Intracerebral drug injection device, the assembly for installing the injection device, and a method for delivering cerebropathy treatment drugs into the human brain

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