CN116687906A - ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 - Google Patents
ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Microbiology (AREA)
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- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195417P | 2015-07-22 | 2015-07-22 | |
| US62/195,417 | 2015-07-22 | ||
| PCT/IB2016/001158 WO2017013496A1 (en) | 2015-07-22 | 2016-07-19 | Enantiomers of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine (anavex2-73) and use thereof in the treatment of alzheimer's disease and other disorders modulated by the sigma 1 receptor |
| CN201680033151.4A CN107708687A (zh) | 2015-07-22 | 2016-07-19 | 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680033151.4A Division CN107708687A (zh) | 2015-07-22 | 2016-07-19 | 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
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| CN116687906A true CN116687906A (zh) | 2023-09-05 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310897135.1A Pending CN116687906A (zh) | 2015-07-22 | 2016-07-19 | ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
| CN201680033151.4A Pending CN107708687A (zh) | 2015-07-22 | 2016-07-19 | 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201680033151.4A Pending CN107708687A (zh) | 2015-07-22 | 2016-07-19 | 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11617734B2 (enExample) |
| EP (2) | EP3324956B1 (enExample) |
| JP (4) | JP7429942B2 (enExample) |
| CN (2) | CN116687906A (enExample) |
| CA (1) | CA2986345A1 (enExample) |
| HK (1) | HK1247847A1 (enExample) |
| WO (1) | WO2017013496A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017013498A2 (en) | 2015-07-22 | 2017-01-26 | Anavex Life Sciences Corp. | Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions |
| US11622955B2 (en) * | 2017-11-28 | 2023-04-11 | Anavex Life Sciences Corp. | Sigma-1 receptor agonist systolic blood pressure therapy |
| EP3773531A4 (en) | 2018-04-12 | 2021-06-23 | Anavex Life Sciences Corp. | A2-73 CRYSTALLINE POLYMORPHIC COMPOSITIONS AND METHOD OF USING THEREOF |
| AU2019269739A1 (en) | 2018-05-18 | 2020-12-10 | Anavex Life Sciences Corp. | Optimized sigma-1 agonist method of responder selection and treatment |
| US12473268B2 (en) | 2020-02-04 | 2025-11-18 | Assia Chemical Industries, Ltd. | Solid state forms of Blarcamesine salts |
| WO2025117826A1 (en) * | 2023-11-30 | 2025-06-05 | Anavex Life Sciences Corp. | Methods of using surrogate biomarkers in sigma-1 receptor therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2636625B1 (fr) | 1988-09-01 | 1990-11-09 | Jouveinal Sa | Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese |
| GR1002616B (el) | 1996-02-21 | 1997-02-20 | Συνθεση και μεθοδος συνθεσης μοριου: τετραυδρο-ν,ν-διμεθυλο-2,2-διφαινυλο-3-φουρανομεθαναμινης (αε 37), αντισπασμωδικης, αντικαταθλιπτικης και νοοτροπικης δρασης. | |
| US20110206780A1 (en) | 2010-01-06 | 2011-08-25 | Auspex Pharmaceuticals, Inc. | Morphinan modulators of nmda receptors, sigma1 receptors, sigma2 receptors, and/or a3b4 nicotinic receptors |
| GR1007686B (el) | 2011-07-08 | 2012-09-12 | Αλεξανδρος Δημητριου Βαμβακιδης | Συνθεση των (+) και (-) 1-(5,5-διφαινυλοτετραϋδροφουραν-3-υλ)-ν,ν-διμεθυλομεθυλαμινης, (+) και (-) 1-(2,2-διφαινυλοτετραϋδροφουραν-3-υλ)-ν,ν-διμεθυλομεθυλαμινης και (+) και (-) 1-(2,2-διφαινυλοτετραϋδροφουραν-3-υλ)-ν-μεθυλομεθυλαμινης |
| RU2014111078A (ru) * | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
| FR2983732B1 (fr) * | 2011-12-09 | 2013-11-22 | Servier Lab | Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent |
| GR1008233B (el) | 2013-03-28 | 2014-06-23 | Αλεξανδρος Δημητριου Βαμβακιδης | Βελτιωση και θεραπευτικη αξιοποιηση της συμπτωματικης αντιμετωπισης της ασθενειας του alzheimer με rivastigmine, galantamine ή donepezil, δια επιλεγμενων αμινοτετραϋδροφουρανιων που δρουν σαν μικτοι σιγμα-1/ μουσκαρινικοι προσδετες |
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2016
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- 2016-07-19 CN CN202310897135.1A patent/CN116687906A/zh active Pending
- 2016-07-19 US US15/579,696 patent/US11617734B2/en active Active
- 2016-07-19 CN CN201680033151.4A patent/CN107708687A/zh active Pending
- 2016-07-19 JP JP2017564725A patent/JP7429942B2/ja active Active
- 2016-07-19 EP EP16827322.5A patent/EP3324956B1/en active Active
- 2016-07-19 EP EP24213545.7A patent/EP4484953A3/en active Pending
- 2016-07-19 HK HK18107442.9A patent/HK1247847A1/zh unknown
- 2016-07-19 CA CA2986345A patent/CA2986345A1/en active Pending
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2025061540A (ja) | 2025-04-10 |
| EP3324956A1 (en) | 2018-05-30 |
| JP7429942B2 (ja) | 2024-02-09 |
| HK1247847A1 (zh) | 2018-10-05 |
| US12208079B2 (en) | 2025-01-28 |
| JP2023073373A (ja) | 2023-05-25 |
| JP7627963B2 (ja) | 2025-02-07 |
| EP4484953A3 (en) | 2025-03-12 |
| US11617734B2 (en) | 2023-04-04 |
| WO2017013496A1 (en) | 2017-01-26 |
| US20180169059A1 (en) | 2018-06-21 |
| US20250120938A1 (en) | 2025-04-17 |
| CN107708687A (zh) | 2018-02-16 |
| JP2018524306A (ja) | 2018-08-30 |
| EP4484953A2 (en) | 2025-01-01 |
| EP3324956B1 (en) | 2024-11-20 |
| CA2986345A1 (en) | 2017-01-26 |
| US20230044710A1 (en) | 2023-02-09 |
| JP2021152077A (ja) | 2021-09-30 |
| EP3324956A4 (en) | 2019-02-20 |
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