CN116687906A - ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 - Google Patents

ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 Download PDF

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Publication number
CN116687906A
CN116687906A CN202310897135.1A CN202310897135A CN116687906A CN 116687906 A CN116687906 A CN 116687906A CN 202310897135 A CN202310897135 A CN 202310897135A CN 116687906 A CN116687906 A CN 116687906A
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sigma
receptor
anavex2
treatment
alzheimer
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Chinese (zh)
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G·內利阿
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Anavex Life Sciences Corp
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Anavex Life Sciences Corp
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Application filed by Anavex Life Sciences Corp filed Critical Anavex Life Sciences Corp
Publication of CN116687906A publication Critical patent/CN116687906A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
CN202310897135.1A 2015-07-22 2016-07-19 ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 Pending CN116687906A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562195417P 2015-07-22 2015-07-22
US62/195,417 2015-07-22
PCT/IB2016/001158 WO2017013496A1 (en) 2015-07-22 2016-07-19 Enantiomers of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine (anavex2-73) and use thereof in the treatment of alzheimer's disease and other disorders modulated by the sigma 1 receptor
CN201680033151.4A CN107708687A (zh) 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680033151.4A Division CN107708687A (zh) 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

Publications (1)

Publication Number Publication Date
CN116687906A true CN116687906A (zh) 2023-09-05

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CN202310897135.1A Pending CN116687906A (zh) 2015-07-22 2016-07-19 ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途
CN201680033151.4A Pending CN107708687A (zh) 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

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CN201680033151.4A Pending CN107708687A (zh) 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

Country Status (7)

Country Link
US (3) US11617734B2 (enExample)
EP (2) EP4484953A3 (enExample)
JP (4) JP7429942B2 (enExample)
CN (2) CN116687906A (enExample)
CA (1) CA2986345A1 (enExample)
HK (1) HK1247847A1 (enExample)
WO (1) WO2017013496A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11617734B2 (en) * 2015-07-22 2023-04-04 Anavex Life Sciences Corp. Enantiomers of A2-73, analogues, and sigma agonist activity
US10413519B2 (en) 2015-07-22 2019-09-17 Anavex Life Sciences Corp. Crystal forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions
CA3083770A1 (en) * 2017-11-28 2019-06-06 Anavex Life Sciences Corp. Sigma-1 receptor agonist systolic blood pressure therapy
WO2019200345A1 (en) 2018-04-12 2019-10-17 Anavex Life Sciences Corp. A2-73 crystalline polymorph compositions of matter and methods of use thereof
JP7582869B2 (ja) 2018-05-18 2024-11-13 アナベックス ライフ サイエンス コーポレイション レスポンダ選択および治療の最適化されたｓｉｇｍａ－１アゴニスト方法
WO2021158586A1 (en) 2020-02-04 2021-08-12 Teva Pharmaceuticals International Gmbh Solid state forms of blarcamesine salts
WO2025117826A1 (en) * 2023-11-30 2025-06-05 Anavex Life Sciences Corp. Methods of using surrogate biomarkers in sigma-1 receptor therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
WO2014155138A1 (en) * 2013-03-28 2014-10-02 Alexandre Vamvakides Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrahydrofurans acting as mixed sigma-1 / muscarinic ligands
CN107708687A (zh) * 2015-07-22 2018-02-16 阿纳韦克斯生命科学公司 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636625B1 (fr) 1988-09-01 1990-11-09 Jouveinal Sa Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese
GR1002616B (el) 1996-02-21 1997-02-20 Συνθεση και μεθοδος συνθεσης μοριου: τετραυδρο-ν,ν-διμεθυλο-2,2-διφαινυλο-3-φουρανομεθαναμινης (αε 37), αντισπασμωδικης, αντικαταθλιπτικης και νοοτροπικης δρασης.
US20110206780A1 (en) 2010-01-06 2011-08-25 Auspex Pharmaceuticals, Inc. Morphinan modulators of nmda receptors, sigma1 receptors, sigma2 receptors, and/or a3b4 nicotinic receptors
AU2012298617B2 (en) 2011-08-25 2016-07-14 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
FR2983732B1 (fr) * 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
WO2014155138A1 (en) * 2013-03-28 2014-10-02 Alexandre Vamvakides Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrahydrofurans acting as mixed sigma-1 / muscarinic ligands
CN107708687A (zh) * 2015-07-22 2018-02-16 阿纳韦克斯生命科学公司 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

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Publication number Publication date
EP3324956A1 (en) 2018-05-30
EP4484953A2 (en) 2025-01-01
US12208079B2 (en) 2025-01-28
HK1247847A1 (zh) 2018-10-05
EP3324956B1 (en) 2024-11-20
US20180169059A1 (en) 2018-06-21
JP2025061540A (ja) 2025-04-10
JP7627963B2 (ja) 2025-02-07
JP2021152077A (ja) 2021-09-30
US11617734B2 (en) 2023-04-04
WO2017013496A1 (en) 2017-01-26
JP2023073373A (ja) 2023-05-25
CA2986345A1 (en) 2017-01-26
JP2018524306A (ja) 2018-08-30
CN107708687A (zh) 2018-02-16
EP4484953A3 (en) 2025-03-12
US20250120938A1 (en) 2025-04-17
JP7429942B2 (ja) 2024-02-09
EP3324956A4 (en) 2019-02-20
US20230044710A1 (en) 2023-02-09

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