CN116686997A - Bifidobacterium adolescentis preparation with sleep quality improving function - Google Patents
Bifidobacterium adolescentis preparation with sleep quality improving function Download PDFInfo
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- CN116686997A CN116686997A CN202310710639.8A CN202310710639A CN116686997A CN 116686997 A CN116686997 A CN 116686997A CN 202310710639 A CN202310710639 A CN 202310710639A CN 116686997 A CN116686997 A CN 116686997A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 241000186018 Bifidobacterium adolescentis Species 0.000 title claims abstract description 38
- 230000003860 sleep quality Effects 0.000 title claims abstract description 23
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000000843 powder Substances 0.000 claims abstract description 33
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 23
- 239000004310 lactic acid Substances 0.000 claims abstract description 23
- 239000011248 coating agent Substances 0.000 claims abstract description 22
- 239000000341 volatile oil Substances 0.000 claims abstract description 22
- 241000208152 Geranium Species 0.000 claims abstract description 11
- 244000178870 Lavandula angustifolia Species 0.000 claims abstract description 11
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims abstract description 11
- 239000001102 lavandula vera Substances 0.000 claims abstract description 11
- 235000018219 lavender Nutrition 0.000 claims abstract description 11
- 241000186605 Lactobacillus paracasei Species 0.000 claims abstract description 10
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 10
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims abstract description 10
- 241000234435 Lilium Species 0.000 claims abstract description 10
- 241000237502 Ostreidae Species 0.000 claims abstract description 10
- 229940072205 lactobacillus plantarum Drugs 0.000 claims abstract description 10
- 235000020636 oyster Nutrition 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims description 62
- 238000001035 drying Methods 0.000 claims description 50
- 238000000227 grinding Methods 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 20
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000010298 pulverizing process Methods 0.000 claims description 11
- 241000186000 Bifidobacterium Species 0.000 claims description 10
- 238000009423 ventilation Methods 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 abstract description 3
- 208000019901 Anxiety disease Diseases 0.000 abstract description 2
- 230000036506 anxiety Effects 0.000 abstract description 2
- 230000008451 emotion Effects 0.000 abstract description 2
- 230000000813 microbial effect Effects 0.000 abstract description 2
- 230000003750 conditioning effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000008681 Phellinus linteus extract Substances 0.000 description 2
- 241000001727 Tropicoporus linteus Species 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 244000236521 Bupleurum rotundifolium Species 0.000 description 1
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000123107 Phellinus Species 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 240000008866 Ziziphus nummularia Species 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 230000036578 sleeping time Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K35/66—Microorganisms or materials therefrom
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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Abstract
The invention discloses a bifidobacterium adolescentis preparation with sleep quality improving function, and relates to the technical field of microbial preparations; in order to ensure the efficacy of the preparation; the components of the composition in parts by weight are as follows: 1000-2000 parts of a component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder; 80-140 parts of a component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily; 50-80 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent. According to the invention, by adding the lavender essential oil and the geranium essential oil, the pressure can be relieved, anxiety and depression can be calmed, depression can be resisted, the tranquilization and mind tranquilization can be realized, the emotion can be stabilized, and the sleep can be effectively improved.
Description
Technical Field
The invention relates to the technical field of microbial preparations, in particular to a bifidobacterium adolescentis preparation with sleep quality improving function.
Background
Sleep disorder, that is to say, the patient has problems in sleeping, and may have symptoms such as excessive sleeping, too little sleeping, difficulty in falling asleep, short sleeping time and the like; sleep disorders are a multiple symptom that most of the reasons for the appearance of such symptoms are due to problems with the health of the patient; conditioning by diet, health care products or medicines is required, and thus, there is a need for a bifidobacterium adolescentis preparation having improved sleep quality.
Through searching, the patent with the Chinese patent application number of CN202110245983.5 discloses a preparation for improving sleep by utilizing Phellinus, which comprises the following components: 2000-3000 g of Phellinus linteus extract, 63-5 g of vitamin B, 280-320 g of lactose and 90-110 g of coating agent. The Phellinus linteus extract is prepared by the following method: pulverizing Phellinus linteus, adding water, and leaching; repeating the extraction for 1 time, combining the two leaching solutions, cooling to room temperature, concentrating under reduced pressure, adding 95% ethanol solution, standing, centrifuging, and collecting precipitate; re-dissolving the precipitate with water, and spray drying. The formulations in the above patents suffer from the following disadvantages: the sleep is conditioned only by the Phellinus linteus component, the efficacy is relatively single, and the conditioning function of human bodies is still to be improved.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a bifidobacterium adolescentis preparation with the function of improving sleep quality.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a bifidobacterium adolescentis preparation with sleep quality improving function comprises the following components in parts by weight:
1000-2000 parts of a component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
80-140 parts of a component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
50-80 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
5 to 16 parts of component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil;
wherein the bifidobacterium adolescentis powder adopts bifidobacterium adolescentis with the strain number of BQ-G66.
Preferably: the preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: and packaging after the detection is qualified.
Further: in the step S3, the concrete mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature at 42-56 ℃ during the grinding process;
s33: sieving with 120-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
Further preferred is: in the step S2, the drying treatment adopts circulating ventilation type drying treatment, and the drying temperature is controlled to be 45-60 ℃.
As a preferred embodiment of the present invention: in the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 10-20 min;
s52: adding lactic acid, and continuously mixing for 5-10 min;
s53: adding the adhesive, and controlling the constant speed of 10-20 min;
s54: continuously mixing for 5-10 min.
Further preferred as the present invention is: the drying temperature in S6 is controlled to be: 38-58 ℃; the thickness of the flattened material is controlled within 8 mm.
As still further aspects of the invention: the components of the composition in parts by weight are as follows:
1400-1600 parts of component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
100-120 parts of component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
65-70 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
10-12 parts of a component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
Based on the scheme: in the step S3, the concrete mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature between 46 and 50 ℃ during the grinding process;
s33: sieving with 200-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
Preferred on the basis of the foregoing scheme: in the step S2, the drying treatment adopts circulating ventilation type drying treatment, and the drying temperature is controlled to be 50-55 ℃; the drying temperature in S6 is controlled to be: 44-48 ℃; the thickness of the flattened material is controlled within 8 mm.
Further preferred on the basis of the foregoing scheme is: in the step S2, the drying treatment adopts circulation ventilation type drying treatment, and the drying temperature is controlled to be 50-55 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 12-15 min;
s52: adding lactic acid, and continuously mixing for 6-8 min;
s53: adding the adhesive, and controlling the constant speed of 12-15 min;
s54: continuously mixing for 6-8 min.
The beneficial effects of the invention are as follows:
1. according to the invention, by adding the lavender essential oil and the geranium essential oil, the pressure can be relieved, anxiety and depression can be calmed, depression can be resisted, the tranquilization and mind tranquilization can be realized, the emotion can be stabilized, and the sleep can be effectively improved.
2. The invention further improves the sleep-aiding effect by adding components such as the seeds of the Chinese thorowax, the dried oysters, the wild jujube, the platycladi seeds, the lily and the like to cooperate with the lavender essential oil and the geranium essential oil.
3. According to the invention, the bifidobacterium adolescentis powder, the lactobacillus paracasei powder and the lactobacillus plantarum powder are added, so that the aim of conditioning a human body can be achieved, and the efficacy and quality of a product are improved.
Drawings
Fig. 1 is a graph showing the comparison of efficacy of bifidobacterium adolescentis preparation with sleep quality improvement according to various embodiments.
Detailed Description
The technical scheme of the patent is further described in detail below with reference to the specific embodiments.
Example 1:
a bifidobacterium adolescentis preparation with sleep quality improving function comprises the following components in parts by weight:
1000-2000 parts of a component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
80-140 parts of a component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
50-80 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
5 to 16 parts of component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
Wherein the bifidobacterium adolescentis powder adopts bifidobacterium adolescentis with the strain number of BQ-G66.
The preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: and packaging after the detection is qualified.
In the step S3, the specific mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature at 42-56 ℃ during the grinding process;
s33: sieving with 120-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
In the step S2, the drying treatment adopts circulation ventilation type drying treatment, and the drying temperature is controlled to be 45-60 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 10-20 min;
s52: adding lactic acid, and continuously mixing for 5-10 min;
s53: adding the adhesive, and controlling the constant speed of 10-20 min;
s54: continuously mixing for 5-10 min.
Wherein, the drying treatment temperature in the step S6 is controlled as follows: 38-58 ℃; the thickness of the flattened material is controlled within 8 mm.
Example 2:
a bifidobacterium adolescentis preparation with sleep quality improving function, which comprises the following components in parts by weight:
1200-1400 parts of component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
120-130 parts of component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
60-70 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
8-10 parts of a component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
The preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: and packaging after the detection is qualified.
In the step S3, the specific mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature between 46 and 50 ℃ during the grinding process;
s33: sieving with 140-160 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
In the step S2, the drying treatment adopts circulation ventilation type drying treatment, and the drying temperature is controlled to be 48-50 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 10-12 min;
s52: adding lactic acid, and continuously mixing for 8-10 min;
s53: adding the adhesive, and controlling the constant speed of 12-14 min;
s54: continuously mixing for 6-7 min.
Wherein, the drying treatment temperature in the step S6 is controlled as follows: 40-45 ℃; the thickness of the flattened material is controlled within 8 mm.
Example 3:
a bifidobacterium adolescentis preparation with sleep quality improving function comprises the following components in parts by weight:
1800-2000 parts of component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
80-100 parts of component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
60-70 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
12-16 parts of a component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
The preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: and packaging after the detection is qualified.
In the step S3, the specific mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature to be 48-52 ℃ during the grinding process;
s33: sieving with 140-160 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
In the step S2, the drying treatment adopts circulation ventilation type drying treatment, and the drying temperature is controlled at 52-58 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 18-20 min;
s52: adding lactic acid, and continuously mixing for 8-10 min;
s53: adding the adhesive, and controlling the constant speed of 18-20 min;
s54: continuously mixing for 8-10 min.
Wherein, the drying treatment temperature in the step S6 is controlled as follows: 52-58 ℃; the thickness of the flattened material is controlled within 8 mm.
Example 4:
a bifidobacterium adolescentis preparation with sleep quality improving function comprises the following components in parts by weight:
1400-1600 parts of component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
100-120 parts of component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
65-70 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
10-12 parts of a component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
The preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: and packaging after the detection is qualified.
In the step S3, the specific mode of the grinding treatment is as follows:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature between 46 and 50 ℃ during the grinding process;
s33: sieving with 200-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
In the step S2, the drying treatment adopts circulation ventilation type drying treatment, and the drying temperature is controlled to be 50-55 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 12-15 min;
s52: adding lactic acid, and continuously mixing for 6-8 min;
s53: adding the adhesive, and controlling the constant speed of 12-15 min;
s54: continuously mixing for 6-8 min.
Wherein, the drying treatment temperature in the step S6 is controlled as follows: 44-48 ℃; the thickness of the flattened material is controlled within 8 mm.
Experiment one:
in order to verify the efficacy of the bifidobacterium preparation of the present invention, the preparation of the bifidobacterium is processed in the manner of example 2-example 4, the preparation of the bifidobacterium is evaluated, three groups of testees with irregular work and poor sleep quality are selected, the products prepared in example 2, example 3 and example 4 are taken respectively, and the test is carried out continuously for one week, based on the feedback of the testees, the following conclusion is obtained:
| scheme for the production of a semiconductor device | Sleep-aiding effect | Anti-fatigue effect | Effect of relieving fatigue |
| Example 2 | 91 | 88 | 90 |
| Example 3 | 89 | 93 | 91 |
| Example 4 | 96 | 92 | 95 |
From the above, it was found that the bifidobacterium preparation prepared by the procedure of example 4 had the best efficacy, and therefore, it was prepared according to the procedure of example 4.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (10)
1. A bifidobacterium adolescentis preparation with sleep quality improving function, which is characterized by comprising the following components in parts by weight:
1000-2000 parts of a component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
80-140 parts of a component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
50-80 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
5 to 16 parts of component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
2. A bifidobacterium adolescentis preparation with improved sleep quality as claimed in claim 1, characterised in that the preparation method of the bifidobacterium preparation comprises the following steps:
s1: taking the raw materials in parts by weight for standby;
s2: taking the component B, cleaning, drying, and controlling the water content below 10%;
s3: grinding the dried component B, and mixing to obtain mixed powder;
s4: mixing the mixed powder with the component A to obtain a solid mixed material;
s5: adding component D and lactic acid, mixing again, and gradually adding adhesive during the mixing;
s6: after mixing, drying the materials, and coating by a coating agent;
s7: granulating in a granulator;
s8: packaging after the detection is qualified;
wherein the bifidobacterium adolescentis powder adopts bifidobacterium adolescentis with the strain number of BQ-G66.
3. The bifidobacterium adolescentis preparation with sleep quality improving effect according to claim 2, wherein in step S3, the specific manner of the pulverizing treatment is:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature at 42-56 ℃ during the grinding process;
s33: sieving with 120-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
4. The bifidobacterium adolescentis preparation with improved sleep quality as claimed in claim 2, wherein in step S2, the drying treatment is a circulation ventilation type drying treatment, and the drying temperature is controlled to be 45-60 ℃.
5. The bifidobacterium adolescentis preparation with sleep quality improving effect according to claim 2, wherein in step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 10-20 min;
s52: adding lactic acid, and continuously mixing for 5-10 min;
s53: adding the adhesive, and controlling the constant speed of 10-20 min;
s54: continuously mixing for 5-10 min.
6. A bifidobacterium adolescentis preparation with improved sleep quality as claimed in claim 2, in which the drying treatment temperature in S6 is controlled at: 38-58 ℃; the thickness of the flattened material is controlled within 8 mm.
7. A bifidobacterium adolescentis preparation with improved sleep quality as claimed in any of claims 1-6, characterised in that it comprises the following components in parts by weight:
1400-1600 parts of component A, wherein the component A comprises: 50-70% of bifidobacterium adolescentis powder, 20-40% of lactobacillus paracasei powder and 10-20% of lactobacillus plantarum powder;
100-120 parts of component B, wherein the component B comprises the following components in parts by weight: 30-40% of semen zizaniae, 20-30% of dried oyster, 15-25% of spina date seed, 10-20% of platycladi seed and 10-20% of lily;
65-70 parts of component C, wherein the component C comprises the following components in parts by weight: 30-40% of lactic acid and 60-80% of coating agent;
10-12 parts of a component D, wherein the component D comprises: 50-70% of lavender essential oil and 30-50% of geranium essential oil.
8. The bifidobacterium adolescentis preparation with sleep quality improving effect according to claim 2, wherein in step S3, the specific manner of the pulverizing treatment is:
s31: placing one of the components in the dried component B into a pulverizer for pulverizing;
s32: controlling the temperature between 46 and 50 ℃ during the grinding process;
s33: sieving with 200-240 mesh sieve;
s34: repeating the steps S31-S33 until the grinding treatment of all the components of the component B is finished.
9. The bifidobacterium adolescentis preparation with improved sleep quality according to claim 2, wherein in step S2, the drying treatment is a circulation ventilation type drying treatment, and the drying temperature is controlled to be 50-55 ℃; the drying temperature in S6 is controlled to be: 44-48 ℃; the thickness of the flattened material is controlled within 8 mm.
10. The bifidobacterium adolescentis preparation with improved sleep quality as claimed in claim 2, wherein in step S2, the drying treatment is a circulation ventilation type drying treatment, and the drying temperature is controlled to be 50-55 ℃.
In the step S5, the specific operation mode is as follows:
s51: adding the component D into a mixing device, and mixing for 12-15 min;
s52: adding lactic acid, and continuously mixing for 6-8 min;
s53: adding the adhesive, and controlling the constant speed of 12-15 min;
s54: continuously mixing for 6-8 min.
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