CN116672291A - Private care solution containing nano gold and preparation method thereof - Google Patents
Private care solution containing nano gold and preparation method thereof Download PDFInfo
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- CN116672291A CN116672291A CN202310735055.6A CN202310735055A CN116672291A CN 116672291 A CN116672291 A CN 116672291A CN 202310735055 A CN202310735055 A CN 202310735055A CN 116672291 A CN116672291 A CN 116672291A
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- 239000010931 gold Substances 0.000 title claims abstract description 154
- 229910052737 gold Inorganic materials 0.000 title claims abstract description 154
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims abstract description 103
- 238000002360 preparation method Methods 0.000 title abstract description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
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- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- 241000682855 Aegerita Species 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application relates to the technical field of female care products, and particularly discloses a private care solution containing nano-gold and a preparation method thereof. The private care solution containing the nano gold comprises the following components in percentage by mass: 0.4% -0.6% of nano gold; 4% -6% of 2, 3-butanediol; carbomer 0.1% -0.3%; 0.03% -0.05% of PEG-40 hydrogenated castor oil; 0.1% -0.3% of neutralizer; 0.01% -0.03% of chelating agent; 2% -4% of humectant; 0.4% -2.0% of skin conditioner; the balance of water. The preparation method of the private care solution containing the nano-gold is characterized in that after the components are mixed and stirred uniformly, the private care solution containing the nano-gold is obtained. The private care solution containing the nano-gold prepared by the application has extremely low irritation to vaginal mucosa, has unexpected mild antibacterial effect, and can be used for a long time.
Description
Technical Field
The application relates to the technical field of female care products, in particular to a private care solution containing nano-gold and a preparation method thereof.
Background
The female vagina has a unique physiological structure, is easily infected by harmful bacteria and causes inflammation. Pathogenic bacteria causing female vaginal inflammation are various, and among them, candida albicans, escherichia coli and staphylococcus aureus are the most representative.
With the rise of the personal care concept, more and more women use the private care solution for a long time in life, and they consider that the private care solution is a good sanitary habit, can inhibit pathogenic bacteria and keep the vagina clean. However, in fact, most of the private care solutions sold in the market at present can effectively inhibit candida albicans, escherichia coli, staphylococcus aureus and the like, but all the private care solutions have certain irritation and are not suitable for long-term use. As is well known, the vaginal mucosa is very fragile, if such a private care solution is frequently used, the vaginal mucosa may be damaged, so that the vaginal mucosa is damaged for a long time, and the vagina is more prone to inflammation.
Based on the above-mentioned related art, the applicant believes that there is an urgent need for a low-irritation, personal care solution that can be used for a long period of time for female consumers. Thus, the private care solution has room for further improvement.
Disclosure of Invention
The application provides a private care solution containing nano gold and a preparation method thereof in order to obtain the private care solution with low irritation. The application has good effect of inhibiting the growth of candida albicans, escherichia coli and staphylococcus aureus by matching the nano gold with the 2, 3-butanediol, completely meets the vaginal bacteriostasis requirement, and has unexpected mild bacteriostasis effect due to extremely low irritation to vaginal mucosa by matching the nano gold with the 2, 3-butanediol.
The private care solution containing nano gold provided by the application adopts the following technical scheme:
the private care solution containing the nano gold comprises the following components in percentage by mass:
the balance of water.
In the technical scheme, the nano gold is nano-scale tiny gold particles, the nano gold has high specific surface area due to the tiny particle size, the number of surface active sites of the nano gold is large, and under certain conditions, bacteria and fungi can be unbalanced in metabolism to generate more active oxygen free radicals, so that the effect of destroying thalli of the bacteria and the fungi is achieved, and therefore, the nano gold has certain antibacterial property. However, since the nano gold has certain sensitivity to normal cells and tissues, the nano gold may promote the cells or tissues to generate oxidative stress, so that the nano gold has a certain damage effect to the normal cells and tissues.
According to the application, the nano gold and the 2, 3-butanediol are added into the private care solution containing the nano gold, so that the effect of destroying the thalli of candida albicans, escherichia coli and staphylococcus aureus with good specificity is achieved, and the growth of candida albicans, escherichia coli and staphylococcus aureus can be obviously inhibited. In addition, the cooperation of the nano gold and the 2, 3-butanediol can also effectively reduce the irritation of the nano gold to vaginal mucosa, so that the technical effect of reducing the irritation of the nano gold to normal cells and tissues is achieved, and the mild antibacterial effect of the private care solution containing the nano gold is realized.
According to the application, carbomer and PEG-40 hydrogenated castor oil are further added on the basis of nano-gold and 2, 3-butanediol, so that the private care solution containing nano-gold has good fluidity and a more stable system, each component in the private care solution containing nano-gold can be uniformly dispersed, and the nano-gold can be stably dispersed and suspended in the private care solution containing nano-gold. The private care solution containing the nano-gold has good fluidity and stability, so that the private care solution containing the nano-gold has good use experience.
Preferably, the skin conditioner comprises one or more of a vegetable extract of Etawnia, lemon, passion fruit, and Holly fruit.
In the technical scheme, the vegetable Etawny fruit extract, the lemon fruit extract, the passion fruit extract and the smooth golden tiger fruit extract have good compatibility with the nanometer gold fitting of the private care solution containing the nanometer gold. The skin conditioner is one or more of a vegetable Etawny fruit extract, a lemon fruit extract, a passion fruit extract and a smooth golden tiger fruit extract, and can further promote the nourishing effect of the skin conditioner on vagina on the basis of not affecting the bacteriostasis of the nano gold.
Preferably, the skin conditioner consists of a vegetable extract of Etaya palm fruit, a lemon fruit, an extract of passion fruit and an extract of Holly's tail fruit;
wherein, the mass percentage of the vegetable and edible elaeis henryi fruit extract in the private care solution containing nano gold is 0.1-0.5%; the mass percentage of the lemon fruit extract in the private care solution containing nano gold is 0.1-0.5%;
the mass percentage of the passion fruit extract in the private care solution containing nano gold is 0.1-0.5%;
the mass percentage of the smooth sansevieria trifasciata extract in the private care solution containing the nano-gold is 0.1-0.5%.
According to the technical scheme, the skin conditioner compounded by the vegetable and edible elaeagnus angustifolia fruit extract, the lemon fruit extract, the passion fruit extract and the smooth golden tiger fruit extract has good compatibility with the nanometer hardware fitting, can balance the bacteriostasis of the private care solution containing the nanometer gold, and maintains the normal microenvironment of the female vagina. After the private care solution containing the nano gold, which is added with the skin conditioner, is used for a long time, the reproduction of harmful microorganisms can be reduced to a certain extent, the personal protection effect is achieved, the normal pH value of the vagina can be maintained, the acid-base balance of the vagina is truly regulated, and the vagina has the natural protection capability of better preventing invasion of external pathogens.
Preferably, the private care solution containing nano gold comprises the following components in percentage by mass:
the balance of water.
According to the technical scheme, the skin conditioner compounded by the vegetable and edible elaeagnus angustifolia fruit extract, the lemon fruit extract, the passion fruit extract and the smooth golden tiger fruit extract and the nano gold have better compatibility, and the antibacterial effect of the private care solution containing the nano gold on the growth inhibition effect of candida albicans, escherichia coli and staphylococcus aureus is promoted by cooperation and synergy, so that the environment in the vagina can be further regulated, the natural defensive capability of the vagina to pathogens is improved, and the use feeling of the private care solution containing the nano gold is further improved.
Preferably, the neutralizing agent is triethanolamine.
According to the technical scheme, the triethanolamine is selected as the neutralizer, so that the system stability of the private care solution containing the nano-gold can be further improved, the pH value of the private care solution containing the nano-gold is stabilized to be suitable for the pH value of the environment in the vagina, the damage of the private care solution containing the nano-gold to beneficial bacteria of the vagina is further reduced, and the use feeling of the private care solution containing the nano-gold is further improved.
Preferably, the chelating agent is disodium edetate.
In the technical scheme, disodium ethylenediamine tetraacetate is selected as the chelating agent, so that the efficacy of each component of the private care solution containing the nano gold can be stimulated to the greatest extent.
Preferably, the particle size of the nano gold is 1-10 nm.
In the technical scheme, the nano gold with the particle size of 1-10 nm is selected, so that 2, 3-butanediol can be better matched, and the effect of specifically destroying the thalli of candida albicans, escherichia coli and staphylococcus aureus can be achieved.
Preferably, the private care solution containing nano gold further comprises 0.01-0.02% of essence.
According to the technical scheme, essence is further added into the private care solution containing the nano-gold, so that the private care solution containing the nano-gold is pleasant in smell, and the use experience of the private care solution containing the nano-gold is further improved.
In a second aspect, the application provides a preparation method of a private care solution containing nano gold, which adopts the following technical scheme: a preparation method of a private care solution containing nano gold comprises the following steps:
step 1: mixing water, 2, 3-butanediol, carbomer, chelating agent and humectant, heating to 80-85 ℃, and stirring uniformly;
step 2: cooling to 40-45 deg.c, adding neutralizing agent and stirring;
step 3: adding nano gold, PEG-40 hydrogenated castor oil and a skin conditioner, and uniformly stirring to obtain the private care solution containing the nano gold.
According to the technical scheme, the emulsified water, the 2, 3-butanediol, the carbomer, the chelating agent and the humectant are mixed, the neutralizing agent is added, and the nano gold, the PEG-40 hydrogenated castor oil and the skin conditioning agent are added, so that the activity of active substances is reserved to the greatest extent while the components are mixed, and the private care solution containing the nano gold has a better use effect.
Preferably, the stirring process condition in the step 1 is 2000-2200 r/min for stirring for 3-5 min;
stirring for 1-2 min under the stirring process condition of 2000-2200 r/min;
the stirring process condition of the step 3 is 2000-2200 r/min for stirring for 2-4 min.
According to the technical scheme, through limiting the stirring process conditions of each step, the full reaction fusion of each component of the private care solution containing the nano gold is ensured, and the components can better cooperate to promote the mild antibacterial effect of the private care solution containing the nano gold.
In a third aspect, the present application provides a method for using a private care solution containing nano gold, which adopts the following technical scheme: the application method of the private care solution containing the nano gold comprises the following steps: cleaning hands, taking a proper amount of private care solution containing nano gold in the palm center, then rubbing and washing the vulva skin for 2-3 min, and then washing with clear water.
In summary, the present application includes at least one of the following beneficial technical effects:
1. according to the application, the nano gold and the 2, 3-butanediol are added into the private care solution containing the nano gold, so that the effect of destroying the thalli of candida albicans, escherichia coli and staphylococcus aureus with good specificity is achieved, and the growth of candida albicans, escherichia coli and staphylococcus aureus can be obviously inhibited. In addition, the cooperation of the nano gold and the 2, 3-butanediol can also effectively reduce the irritation of the nano gold to vaginal mucosa, so that the technical effect of reducing the irritation of the nano gold to normal cells and tissues is achieved, and the mild antibacterial effect of the private care solution containing the nano gold is realized.
2. According to the application, carbomer and PEG-40 hydrogenated castor oil are further added on the basis of nano-gold and 2, 3-butanediol, so that the private care solution containing nano-gold has good fluidity and a more stable system, each component in the private care solution containing nano-gold can be uniformly dispersed, and the nano-gold can be stably dispersed and suspended in the private care solution containing nano-gold. The private care solution containing the nano-gold has good fluidity and stability, so that the private care solution containing the nano-gold has good use experience.
3. According to the application, by adding the vegetable and edible elaeagnus angustifolia fruit extract, the lemon fruit extract, the passion fruit extract and the sansevieria trifasciata fruit extract into the private care solution containing the nano-gold, the antibacterial property of the private care solution containing the nano-gold can be balanced, and the normal microenvironment of female vagina can be maintained. After the private care solution containing the nano gold, which is added with the skin conditioner, is used for a long time, the reproduction of harmful microorganisms can be reduced to a certain extent, the personal protection effect is achieved, the normal pH value of the vagina can be maintained, the acid-base balance of the vagina is truly regulated, and the vagina has the natural protection capability of better preventing invasion of external pathogens.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present application, the present application will be further described with reference to the following specific examples.
The sources of partial raw materials of the application are shown in the following table:
| raw material name | Manufacturer' s |
| Carbomer (carbomer) | Lu Borun Special chemical (Shanghai) Co., ltd |
| Nano gold | Guangdong Guangnalt Fei technology Co., ltd |
| Elaeagnus angustifolia fruit extract | Brazilian ASSESSA |
| Lemon fruit extract | Brazilian ASSESSA |
| Plumeria rubra fruit extract | Brazilian ASSESSA |
| Extract of the fruit of Holly | Brazilian ASSESSA |
| 2, 3-butanediol | GUANGDONG TSINGHUA SMART BIOTECH Co.,Ltd. |
| PEG-40 hydrogenated castor oil | GUILIN LIKAITE ENVIRONMENT PROTECTION INDUSTRY Co.,Ltd. |
| Essence | Hanbit Flavor&Fragrance Co.,Ltd |
Example 1
A private care solution containing nano gold comprises 90.91g of water, 0.4g of nano gold, 6g of 2, 3-butanediol, 0.1g of carbomer, 0.05g of PEG-40 hydrogenated castor oil, 0.1g of neutralizer, 0.03g of chelating agent, 2g of humectant, 0.01g of essence and 0.4g of skin conditioner.
Wherein the grain diameter of the nano gold is 1-10 nm.
Wherein the neutralizing agent is triethanolamine.
Wherein the chelating agent is disodium edetate.
Wherein the humectant is glycerin.
Wherein the skin conditioner is a vegetable Etapalm fruit extract.
The preparation method of the private care solution containing the nano gold comprises the following steps:
step 1: mixing water, 2, 3-butanediol, carbomer, chelating agent and humectant, heating to 85deg.C, and stirring at 2000r/min for 5min;
step 2: cooling to 45deg.C, adding neutralizer, stirring at 2200r/min for 1min;
step 3: adding nano gold, PEG-40 hydrogenated castor oil and skin conditioner, stirring for 2min at 2200r/min to obtain private care solution containing nano gold.
Example 2
A private care solution containing nano-gold, unlike example 1, comprises 89.54g of water, 0.6g of nano-gold, 4g of 2, 3-butanediol, 0.3g of carbomer, 0.03g of PEG-40 hydrogenated castor oil, 0.3g of neutralizer, 0.01g of chelating agent, 4g of humectant, 0.02g of essence and 1.2g of skin conditioner.
The preparation method of the private care solution containing the nano gold comprises the following steps:
step 1: mixing water, 2, 3-butanediol, carbomer, chelating agent and humectant, heating to 80deg.C, stirring at 2200r/min for 3min;
step 2: cooling to 40deg.C, adding neutralizer, and stirring at 2000r/min for 2min;
step 3: adding nano gold, PEG-40 hydrogenated castor oil and skin conditioner, stirring for 4min at 2000r/min to obtain private care solution containing nano gold.
Example 3
A private care solution containing nano-gold, unlike example 1, comprises 89.03g of water, 0.5g of nano-gold, 5g of 2, 3-butanediol, 0.2g of carbomer, 0.04g of PEG-40 hydrogenated castor oil, 0.2g of neutralizer, 0.02g of chelating agent, 3g of humectant, 0.01g of essence and 2g of skin conditioner.
Example 4
Unlike example 3, the skin conditioner consisted of 0.1g of the extract of Eta palm fruit, 0.1g of the extract of lemon fruit, 0.1g of the extract of passion fruit, 0.1g of the extract of smooth passion fruit, and the amount of water was changed to 90.63g.
Example 5
Unlike example 3, the skin conditioner consisted of 0.3g of the extract of Eta palm fruit, 0.3g of the extract of lemon fruit, 0.3g of the extract of passion fruit, 0.3g of the extract of smooth passion fruit, and the amount of water was 89.83g.
Example 6
Unlike example 3, the skin conditioner consisted of 0.5g of the extract of Eta palm fruit, 0.5g of the extract of lemon fruit, 0.5g of the extract of passion fruit, 0.5g of the extract of smooth passion fruit, and the amount of water was 89.03g.
Example 7
Unlike example 6, the private care solution containing nano gold was replaced with blueberry fruit extract in equal amount by the extract of the elaeis aegerita fruit.
Wherein the blueberry fruit extract is commercially available.
Example 8
Unlike example 6, the lemon fruit extract was replaced with lime extract in equal amounts.
Wherein the lime extract is commercially available.
Example 9
A private care solution containing nano-gold is different from example 6 in that the extract of passion fruit is replaced with the extract of calendula officinalis in equal amount.
Wherein the calendula extract is commercially available.
Example 10
A private care solution containing nano gold is different from example 6 in that the extract of the fruit of Saxifraga stolonifera is replaced by the extract of Portulaca oleracea.
Wherein the purslane extract is commercially available.
Comparative example 1
Unlike example 3, the private care solution containing nano gold contained 0.2g of nano gold and 89.33g of water.
Comparative example 2
Unlike example 3, the private care solution containing nano gold contained 0.8g of nano gold and 88.73g of water.
Comparative example 3
Unlike example 3, the private care solution containing nano gold had a 2g content of 2, 3-butanediol and a 92.03g content of water.
Comparative example 4
Unlike example 3, the private care solution containing nano gold had a 2, 3-butanediol content of 8g and a water content of 86.03g.
Comparative example 5
Unlike example 3, the private care solution containing nano gold was prepared by replacing 2, 3-butanediol with 1, 3-butanediol in equal amounts.
Comparative example 6
Unlike example 3, the private care solution containing nano gold was replaced with xanthan gum in equal amount.
Comparative example 7
Unlike example 3, the private care solution containing nano-gold was replaced with PEG-20 hydrogenated castor oil in equal amounts.
Performance detection
And (3) antibacterial effect test:
and evaluating the antibacterial effectiveness by a carrier soaking quantitative sterilization test method according to the 5.2.2 standard in WS/T650-2019.
The private care solutions containing gold nanoparticles of the above examples and comparative examples were evaluated for their antibacterial properties in 17 groups (3 samples each) of candida albicans (ATCC 10231), escherichia coli (ATCC 25922) and staphylococcus aureus (ATCC 6538), respectively. The specific bacteriostasis test results (averaged) are shown in table 1.
Skin irritation test:
the irritation of the private care solution containing the nano gold was evaluated according to the one-time complete skin irritation test of item 2.3.4 of the disinfection technical Specification (2002 edition), and the skin irritation degree of the private care solution containing the nano gold to a common New Zealand white rabbit was detected.
Test animals: 21 New Zealand white rabbits of ordinary grade, weight 2.0-3.0 kg, offered by the professional Cooperation of the gold rabbit industry in Jiashan county (production), approval document: zhejiang syndrome (2019) 05022. The test animals were randomly divided into 7 groups of 3 animals.
Test article: the private care solutions containing nano-gold of example 3 and comparative examples 1 to 5.
Raising test animals under the environment with the temperature of 18-23 ℃ and the relative humidity of 45% -65%, removing hairs at two sides of the spine of the back of the test animals 24 hours before the test to avoid damaging skin, taking 0.5ml of a test object respectively, smearing the test object on two layers of gauze (2.5 cm x 2.5 cm) and directly applying the test object on the skin of a test part at one side, adopting a closed test, removing the dressing after 4 hours, and cleaning the contact part with warm water. The skin erythema and edema responses were observed 1, 24, 48 hours after removal of the test subjects, respectively, and the integral was performed according to the scoring criteria of the skin irritation response, and the average of the integral of the skin irritation response at each set of different time points was obtained and recorded in table 2.
The highest skin irritation response integral mean for each group was selected as the skin irritation index, and the irritation was evaluated and recorded in table 2. Wherein the skin irritation index is 0 to <0.5, representing no irritation, 0.5 to <2.0, representing light irritation, 2.0 to <6.0, representing medium irritation, 6.0 to <8.0, representing strong irritation,
freeze thawing cycle stability test:
after the sample is placed in an environment of minus 20+/-5 ℃ for 24 hours and then placed in an environment of 25+/-5 ℃ for 24 hours, the composition is continuously circulated for five times, and the composition state is observed each time, if layering, precipitation or aggregation phenomenon still exists after five times of circulation, the freeze-thawing circulation stability is qualified, and the test result is shown in Table 3.
Consumer testing:
170 female volunteers from different areas with ages of 30-35 are selected, and the volunteers are divided into 17 groups of 10 persons, and each group uses the private care solution containing nano gold in each of the examples and the comparative examples.
1. The test required continuous use of the private care solution containing nanogold for 1 week in each volunteer, followed by pH measurement of vaginal secretions using a Lei Ci PHS-3E precision pH meter, respectively, and recorded (averaged per group) in table 3. It should be noted that the normal pH of female vaginal secretions generally ranges from 3.5 to 4.5, with greater pH values exceeding 4.5 being indicative of greater environmental disorders within the vagina.
2. Volunteers rated satisfaction with private care solutions containing nanogold, from mild effects, cleaning effects, care effects, and recorded (averaged per group) in table 3.
The mild effect scoring criteria are as follows:
0 to 59 minutes: the first time of use has a slight tingling pain;
60-79 minutes: the product has slight heat sensation after first use;
80-100 minutes: no discomfort is felt after the first use.
The cleaning performance scoring criteria were as follows:
0 to 59 minutes: after continuous use for one week, the vulva still has peculiar smell and is easy to feel itching;
60-79 minutes: the vulva is easy to have peculiar smell after being continuously used for a week;
80-100 minutes: the vulva can keep a state without peculiar smell for a whole day after continuously using for a week.
The care effect scoring criteria are as follows:
0 to 59 minutes: the vulva skin is tight after continuous use for a week;
60-79 minutes: the vulva skin is not tight after continuous use for a week;
80-100 minutes: after continuous use for one week, the vulva skin is not tight, and the skin becomes finer.
Table 1:
table 2:
table 3:
by combining example 3, comparative example 5 and tables 1 to 3, it can be obtained that the addition of nanogold and 2, 3-butanediol simultaneously to the nanogold-containing private care solution has good effect of inhibiting the growth of candida albicans, escherichia coli and staphylococcus aureus. Specific analysis shows that the compounding of the nano gold and the 2, 3-butanediol has specificity, and the 2, 3-butanediol plays a vital role in inhibiting the antibacterial effect of the private care solution containing the nano gold, and only the compounding of the nano gold and the 2, 3-butanediol has good role in inhibiting the growth of candida albicans, escherichia coli and staphylococcus aureus.
By combining example 3, comparative examples 1-4 and tables 1-3, it can be obtained that the private care solution containing nano gold is added with 0.4% -0.6% of nano gold and 4% -6% of 2, 3-butanediol at the same time, and has good mild antibacterial effect. Specific analysis shows that the addition amount of 0.4-0.6% of the nano gold and the addition amount of 4-6% of the 2, 3-butanediol have specificity, and the nano gold and the 2, 3-butanediol can well balance the antibacterial effect and the mild effect of the private care solution containing the nano gold only within the range of values, so that the mild antibacterial effect of the private care solution containing the nano gold can be realized.
By combining example 3, comparative examples 6-7 and Table 3, it can be obtained that carbomer and PEG-40 hydrogenated castor oil are further added into the private care solution containing nano-gold, so that the stability of the private care solution containing nano-gold can be improved, the components in the private care solution containing nano-gold can be uniformly dispersed, the nano-gold can be stably dispersed and suspended in the private care solution containing nano-gold, and the private care solution containing nano-gold has good use experience.
By combining the embodiment 3, the embodiment 4-6, the embodiment 7-10, the table 1 and the table 3, the effect of maintaining the normal vaginal pH value is good by adding the Elsholtzia serrata fruit extract, the lemon fruit extract, the passion fruit extract and the sansevieria trifasciata fruit extract into the private care solution containing the nano gold. The specific analysis shows that the combination of the vegetable and edible elaeagnus angustifolia extract, the lemon fruit extract, the passion fruit extract and the glabrous greenbrier rhizome extract has specificity, can balance the bacteriostasis of the private care solution containing the nano gold, condition and maintain the normal pH value of the vagina of a female, can reduce the invasion of harmful microorganisms to the vagina after long-term use, and can regulate the environment in the vagina, so that the vagina has the natural protection capability of better preventing the invasion of external pathogens.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (9)
1. The private care solution containing the nano gold is characterized by comprising the following components in percentage by mass:
nano gold: 0.4% -0.6%;
2, 3-butanediol: 4% -6%;
carbomer: 0.1% -0.3%;
PEG-40 hydrogenated castor oil: 0.03% -0.05%;
neutralizing agent: 0.1% -0.3%;
chelating agent: 0.01% -0.03%;
humectant: 2% -4%;
skin conditioning agent: 0.4% -2.0%;
the balance of water.
2. The private gold-containing care solution according to claim 1, wherein the skin conditioning agent comprises one or more of extracts of eriophyllum decastes, lemon fruit, passion fruit, and sansevieria glabra.
3. The private care solution containing nano-gold according to claim 2, wherein the skin conditioner is composed of extracts of erigeron breviscapus, lemon fruit, passion fruit, and sansevieria trifasciata;
wherein, the mass percentage of the vegetable and edible elaeis henryi fruit extract in the private care solution containing nano gold is 0.1% -0.5%;
the mass percentage of the lemon fruit extract in the private care solution containing nano gold is 0.1% -0.5%;
the mass percentage of the passion fruit extract in the private care solution containing nano gold is 0.1% -0.5%;
the mass percentage of the smooth golden tiger fruit extract in the private care solution containing the nano gold is 0.1% -0.5%.
4. The private care solution containing nano-gold according to claim 3, wherein the private care solution containing nano-gold comprises the following components in percentage by mass:
nano gold: 0.4% -0.6%;
2, 3-butanediol: 4% -6%;
carbomer: 0.1% -0.3%;
PEG-40 hydrogenated castor oil: 0.03% -0.05%;
neutralizing agent: 0.1% -0.3%;
chelating agent: 0.01% -0.03%;
humectant: 2% -4%;
the extract of the Eta palm fruit is used for vegetable food: 0.3% -0.5%;
lemon fruit extract: 0.3% -0.5%;
passion fruit extract: 0.3% -0.5%;
extract of the fruit of the sansevieria trifasciata: 0.3% -0.5%;
the balance of water.
5. The private care solution containing nano-gold according to claim 1, wherein the neutralizing agent is triethanolamine.
6. The private care solution containing nano-gold according to claim 1, wherein the chelating agent is disodium edetate.
7. The private care solution containing nano-gold according to claim 1, wherein the particle size of the nano-gold is 1-10 nm.
8. A method for preparing the private care solution containing nano-gold according to any one of claims 1 to 7, comprising the following steps:
step 1: mixing water, 2, 3-butanediol, carbomer, a chelating agent and a humectant, heating to 80-85 ℃, and uniformly stirring;
step 2: cooling to 40-45 ℃, adding a neutralizing agent, and uniformly stirring;
step 3: adding nano gold, PEG-40 hydrogenated castor oil and a skin conditioner, and uniformly stirring to obtain the private care solution containing the nano gold.
9. The method for preparing the private care solution containing nano-gold according to claim 8, wherein the stirring process condition in the step 1 is 2000-2200 r/min for stirring for 3-5 min;
stirring for 1-2 min under the stirring process condition of 2000-2200r/min;
and (3) stirring for 2-4 min under the stirring process condition of 2000-2200r/min.
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| CN110123687A (en) * | 2019-04-26 | 2019-08-16 | 广州科恩生物技术有限公司 | One kind is releived remediation composition and preparation method thereof |
| CN111801108A (en) * | 2018-01-02 | 2020-10-20 | 斯金基克有限责任公司 | Topical skin care compositions |
| CN115006325A (en) * | 2022-06-16 | 2022-09-06 | 问舒(宁波)科技有限公司 | Anti-aging cosmetic emulsion containing nanogold and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170056148A (en) * | 2015-11-13 | 2017-05-23 | 성훈경 | Mask pack composition for skin beauty and mask pack for skin beauty comprising the same |
| CN111801108A (en) * | 2018-01-02 | 2020-10-20 | 斯金基克有限责任公司 | Topical skin care compositions |
| CN110123687A (en) * | 2019-04-26 | 2019-08-16 | 广州科恩生物技术有限公司 | One kind is releived remediation composition and preparation method thereof |
| CN115006325A (en) * | 2022-06-16 | 2022-09-06 | 问舒(宁波)科技有限公司 | Anti-aging cosmetic emulsion containing nanogold and preparation method thereof |
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