CN116617331A - Bagged seasoning tea for treating gout - Google Patents
Bagged seasoning tea for treating gout Download PDFInfo
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- CN116617331A CN116617331A CN202310582267.5A CN202310582267A CN116617331A CN 116617331 A CN116617331 A CN 116617331A CN 202310582267 A CN202310582267 A CN 202310582267A CN 116617331 A CN116617331 A CN 116617331A
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Classifications
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- A23F3/00—Tea; Tea substitutes; Preparations thereof
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention provides bagged seasoning tea for treating gout, and belongs to the technical field of seasoning tea. The bagged seasoning tea disclosed by the invention is a medicinal and edible product, has a scientific formula, is mainly used for strengthening vital qi, nourishing kidney and liver, has excellent compatibility of monarch and minister materials, can block gout attack, has no toxic or side effect, can comprehensively correct uric acid metabolism, thoroughly eliminates uric acid precipitation, is not easy to relapse after treatment, is thorough in treatment and convenient to take, does not damage spleen and stomach, can well protect liver and kidney, and has a wide application prospect.
Description
Technical Field
The invention relates to the technical field of seasoning tea, in particular to bagged seasoning tea for treating gout.
Background
Gout is a disease that results in tissue damage due to long-term purine metabolic dysfunction, elevated blood uric acid. Clinical statistics show that gout can cause a plurality of serious complications such as coronary heart disease, uremia, renal failure, nausea, tumor and the like. The persistent hyperuricemia of gout patients can cause excessive urate crystals to precipitate in coronary arteries, and the coagulation of platelets and bad cholesterol can easily form atherosclerosis to cause coronary heart disease. In addition, prolonged hyperuricemia can cause excessive urate crystals to precipitate in the kidneys, resulting in gouty nephropathy, leading to kidney stones, uremia and renal failure. Half of gout patients develop renal hypertension due to renal dysfunction. Furthermore, accumulation of a large amount of toxins may cause canceration of the body. Gout has been a high risk factor for cancer onset in many countries in europe and america.
At present, western medicine has no radical cure method for pain and wind, and only symptomatic treatment is carried out. Colchicine is generally used clinically to relieve acute episodes of gout, or to relieve pain, pain-relieving and inflammation-diminishing phenylbutazone, and to relieve pain. Once the tophus is formed and large, it can only be removed by surgery. And the long-term excessive taking of western medicines such as colchicine and the like has great harm to the liver and the kidney. It is counted that nearly 1/4 of patients eventually develop uremia, renal failure, etc. In addition, the traditional western medicine treatment can not radically cure and repeatedly attack, and is also easy to cause gastrointestinal irritation, rash, drug heat and the like.
Disclosure of Invention
The invention aims to provide the bagged seasoning tea for treating gout, which is a medicinal and edible product, has a scientific formula, mainly strengthens healthy qi, nourishes kidney and liver, has excellent compatibility of monarch and minister materials, can block gout attack, has no toxic or side effect, can comprehensively correct uric acid metabolism, thoroughly eliminates uric acid precipitation, is not easy to relapse after treatment, is thorough in treatment and convenient to take, does not damage spleen and stomach, can well protect liver and kidney, and has wide application prospect.
The technical scheme of the invention is realized as follows:
the invention provides a bagged seasoning tea for treating gout, which comprises the following raw materials: black tea, hawthorn, poria cocos, chinese yam, dried orange peel, lotus leaf and lily.
As a further improvement of the invention, the invention is prepared from the following raw materials in weight g: 10-15g of black tea, 3-5g of hawthorn, 5-7g of poria cocos, 4-6g of Chinese yam, 2-3g of dried orange peel, 1-3g of lotus leaf and 3-5g of lily.
As a further improvement of the invention, the invention is prepared from the following raw materials in weight g: 12g of black tea, 4g of hawthorn, 6g of poria cocos, 5g of Chinese yam, 2.5g of dried orange peel, 2g of lotus leaf and 4g of lily.
The invention further provides a preparation method of the bagged seasoned tea for treating gout, which comprises the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, heating, boiling, extracting, filtering and drying to obtain an extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's medium, and performing activation culture to obtain strain seed liquid;
s4, adding the filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid and complex enzyme obtained in the step S3, fermenting and culturing, filtering, and freeze-drying to obtain a fermentation product;
s5, uniformly mixing the extract prepared in the step S2 and the fermentation product prepared in the step S4 to prepare the bagged seasoned tea for treating gout.
As a further improvement of the present invention, the solid-to-liquid ratio of the mixed powder and water in step S2 is 1:5-10g/mL, wherein the extraction time is 2-3h.
As a further improvement of the invention, the condition of the activation culture in the step S3 is 36-38 ℃,50-70r/min, the activation culture is carried out for 18-24 hours, and the bacterial seed liquid contains 10 percent of bacteria 8 -10 9 cfu/mL。
As a further improvement of the invention, the inoculation amount of the lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid in the step S4 is 2-3% and 1-2% respectively, the compound enzyme is at least one of cellulase, pectase, papain, ficin, neutral protease, trypsin and amylase, the addition amount of the compound enzyme is 1-2wt% of the total mass of the system, the fermentation culture condition is 36-38 ℃,50-70r/min, and the fermentation culture is 36-48h.
As a further improvement of the invention, the complex enzyme comprises cellulase and ficin with a mass ratio of 5-7:2.
As a further improvement of the present invention, the mass ratio of the extract to the fermentation product in step S5 is 5-7:10-12.
As a further improvement of the present invention, the method specifically comprises the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, wherein the solid-liquid ratio of the mixed powder to the water is 1: extracting at 5-10g/mL under boiling for 2-3 hr, filtering, and drying to obtain extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's culture medium, and performing activation culture for 18-24 hours at 36-38 ℃ and 50-70r/min to obtain strain seed liquid with the bacterial content of 10 8 -10 9 cfu/mL;
S4, adding filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid obtained in the step S3, wherein the inoculum size is 2-3% and 1-2% of the total mass of the system, adding 1-2% of complex enzyme by weight, fermenting and culturing at 36-38 ℃ for 36-48 hours at 50-70r/min, filtering, and freeze-drying to obtain a fermentation product;
the compound enzyme comprises cellulase and ficin with the mass ratio of 5-7:2;
s5, uniformly mixing 5-7g of the extract prepared in the step S2 and 10-12 g of the fermentation product prepared in the step S4 to prepare the bagged seasoned tea for treating gout.
The invention has the following beneficial effects: the bagged seasoning tea disclosed by the invention is a medicinal and edible product, has a scientific formula, is mainly used for strengthening vital qi, nourishing kidney and liver, has excellent compatibility of monarch and minister materials, can block gout attack, has no toxic or side effect, can comprehensively correct uric acid metabolism, thoroughly eliminates uric acid precipitation, is not easy to relapse after treatment, is thorough in treatment and convenient to take, does not damage spleen and stomach, can well protect liver and kidney, and has a wide application prospect.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a bagged seasoned tea for treating gout.
Raw material composition (weight g): 10g of black tea, 3g of hawthorn, 5g of poria cocos, 4g of Chinese yam, 2g of dried orange peel, 1g of lotus leaf and 3g of lily.
The preparation method specifically comprises the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, wherein the solid-liquid ratio of the mixed powder to the water is 1: extracting with boiling water for 2 hr at 5g/mL, filtering, and drying to obtain extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's culture medium, and performing activation culture for 18 hours at 36 ℃ and 50 r/min to obtain strain seed liquid with the bacterial content of 10 8 cfu/mL;
S4, adding filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid obtained in the step S3, wherein the inoculum size is 2% and 1% respectively, then adding 1wt% of complex enzyme of the total mass of the system, fermenting and culturing at 36 ℃ for 36 hours at 50 r/min, filtering, and freeze-drying to obtain a fermentation product;
the compound enzyme comprises cellulase and ficin with a mass ratio of 5:2;
s5, uniformly mixing 5g of the extract prepared in the step S2 and 10g of the fermentation product prepared in the step S4, and preparing the bagged seasoned tea for treating gout.
Example 2
The embodiment provides a bagged seasoned tea for treating gout.
Raw material composition (weight g): 15g of black tea, 5g of hawthorn, 7g of poria cocos, 6g of Chinese yam, 3g of dried orange peel, 3g of lotus leaf and 5g of lily.
The preparation method specifically comprises the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, wherein the solid-liquid ratio of the mixed powder to the water is 1: heating and boiling 10g/mL for 3h, filtering, and drying to obtain extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's culture medium, and performing activation culture for 24 hours at 38 ℃ and 70r/min to obtain strain seed liquid with the bacterial content of 10 9 cfu/mL;
S4, adding filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid obtained in the step S3, wherein the inoculum size is 3% and 2% respectively, then adding 2wt% of complex enzyme of the total mass of the system, fermenting and culturing at 38 ℃ for 48 hours at 70r/min, filtering, and freeze-drying to obtain a fermentation product;
the compound enzyme comprises cellulase and ficin with the mass ratio of 7:2;
s5, uniformly mixing 7g of the extract prepared in the step S2 and 12g of the fermentation product prepared in the step S4 to prepare the bagged seasoned tea for treating gout.
Example 3
The embodiment provides a bagged seasoned tea for treating gout.
Raw material composition (weight g): 12g of black tea, 4g of hawthorn, 6g of poria cocos, 5g of Chinese yam, 2.5g of dried orange peel, 2g of lotus leaf and 4g of lily.
The preparation method specifically comprises the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, wherein the solid-liquid ratio of the mixed powder to the water is 1:7g/mL, heating and boiling for 2.5h, filtering, and drying to obtain extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's culture medium, and performing activation culture for 21 hours at 37 ℃ and 60 r/min to obtainTo strain seed liquid with a bacterial content of 10 9 cfu/mL;
S4, adding filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid obtained in the step S3, wherein the inoculum size is 2.5% and 1.5% respectively, then adding 1.5% by weight of complex enzyme of the total mass of the system, fermenting and culturing at 37 ℃ for 42h at 60 r/min, filtering, and freeze-drying to obtain a fermentation product;
the compound enzyme comprises cellulase and ficin with the mass ratio of 6:2;
s5, uniformly mixing 6g of the extract prepared in the step S2 and 11 g of the fermentation product prepared in the step S4, and preparing the bagged seasoned tea for treating gout.
Test example 1
120 cases of gouty arthritis patients. The random groups were four. Examples 1-3, 30 for each group, 30 for the control group.
Inclusion criteria:
(1) Meets the diagnosis standard in the diagnosis and treatment guide of primary gout formulated by the college of rheumatology of China medical society in 2011, meets the diagnosis standard of phlegm-dampness collateral obstruction type gout formulated by the Chinese medicine science of Zhou Zhong Ji, and the blood uric acid is more than or equal to 420 mu mo L/L after diet control;
(2) Age 22-65 years old;
(3) Voluntary test and sign informed consent.
Exclusion criteria:
(1) Combining severe cardiovascular and cerebrovascular diseases, liver and kidney insufficiency, severe gastrointestinal diseases and blood system diseases;
(2) Those who have affected uric acid by recent administration;
(3) Pregnant and lactating women;
(4) Serious joint deformity;
(5) Poor dietary control and therapeutic compliance.
In this study, the two groups were compared in terms of age, sex, body mass index, course of disease, etc., and the differences were not statistically significant (P > 0.05), and were comparable.
Basic treatment of treatment method: proper rest, avoiding tiredness and catching cold, avoiding high purine diet (such as seafood, animal viscera, bean products, etc.), prohibiting smoking and drinking, and drinking white boiled water of more than 2000mL each day. Control group: allopurinol tablet is orally taken half an hour after meals, 3 times/day, 100 mg/time (Shang Xin Yi Wan Xiang Chemie Co., ltd.). Examples 1-3 groups: a bag of seasoning tea for treating gout is prepared by soaking 3 times per day and 20g per time.
And (3) observing the indexes:
the Chinese medicine syndromes are integrated: the integration of the Chinese medicine symptoms of the two groups of patients is calculated respectively before treatment, 6 weeks after treatment and 12 weeks after treatment, and the evaluation standard of the 2002 edition of Chinese medicine clinical study guidelines is referred to, wherein the evaluation of the symptoms of joint pain, joint swelling, listlessness, aversion to cold, cold limbs, head and body heaviness, epigastric fullness and tophus 7 is carried out, and the symptoms of no symptom, mild symptom, moderate symptom and severe symptom are respectively 0, 2, 4 and 6 minutes, and then average division is calculated.
And (3) judging curative effect: clinical efficacy assessment is performed 12 weeks after treatment by referring to 2002 edition of "guidelines for clinical research on New Chinese medicine". The effect is shown: UA is reduced to less than or equal to 380 mu mo L/L after treatment, and is reduced by more than or equal to 30% compared with the UA before treatment; the method is effective: UA drops to less than or equal to 440 mu mo L/L after treatment, but more than 380 mu mo L/L, or drops by more than or equal to 15% but less than 30% compared with the prior treatment; invalidation: UA > 440 mu mo L/L after treatment, or decrease < 15% or even increase compared to pre-treatment. Total effective rate= (effective + effective) number of cases/total number of cases x 100%.
The results are shown in tables 1 and 2.
TABLE 1
Group of | 0 week | For 6 weeks | For 12 weeks |
Example 1 | 3.11±1.02 | 2.10±1.22 | 0.87±0.78 |
Example 2 | 3.09±1.11 | 2.08±1.17 | 0.84±0.82 |
Example 3 | 3.02±1.08 | 2.04±0.98 | 0.82±0.85 |
Control group | 3.20±0.98 | 2.32±1.28 | 1.72±1.14 |
TABLE 2
Group of | Has obvious effect | Effective and effective | Invalidation of |
Example 1 | 12 | 17 | 1 |
Example 2 | 13 | 16 | 1 |
Example 3 | 14 | 16 | 0 |
Control group | 6 | 18 | 6 |
From the above table, the bagged seasoning tea for treating gout prepared in the embodiments 1-3 has good effect of treating gouty arthritis.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (10)
1. The bagged seasoning tea for treating gout is characterized by comprising the following raw materials: black tea, hawthorn, poria cocos, chinese yam, dried orange peel, lotus leaf and lily.
2. The bagged seasoned tea for treating gout according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10-15g of black tea, 3-5g of hawthorn, 5-7g of poria cocos, 4-6g of Chinese yam, 2-3g of dried orange peel, 1-3g of lotus leaf and 3-5g of lily.
3. The bagged seasoned tea for treating gout according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 12g of black tea, 4g of hawthorn, 6g of poria cocos, 5g of Chinese yam, 2.5g of dried orange peel, 2g of lotus leaf and 4g of lily.
4. A method of preparing a teabag for the treatment of gout according to any of claims 1 to 3 comprising the steps of:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, heating, boiling, extracting, filtering and drying to obtain an extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's medium, and performing activation culture to obtain strain seed liquid;
s4, adding the filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid and complex enzyme obtained in the step S3, fermenting and culturing, filtering, and freeze-drying to obtain a fermentation product;
s5, uniformly mixing the extract prepared in the step S2 and the fermentation product prepared in the step S4 to prepare the bagged seasoned tea for treating gout.
5. The method according to claim 4, wherein the solid-to-liquid ratio of the mixed powder and water in step S2 is 1:5-10g/mL, wherein the extraction time is 2-3h.
6. The method according to claim 4, wherein the condition of the activation culture in the step S3 is 36-38deg.C, 50-70r/min, and the culture is activated for 18-24 hours, and the bacterial seed solution has a bacterial content of 10 8 -10 9 cfu/mL。
7. The preparation method of claim 4, wherein the seed solution of Lactobacillus plantarum and Bifidobacterium adolescentis in the step S4 is inoculated in an amount of 2-3% and 1-2% respectively, the compound enzyme is at least one of cellulase, pectase, papain, ficin, neutral protease, trypsin and amylase, the adding amount of the compound enzyme is 1-2wt% of the total mass of the system, the condition of fermentation culture is 36-38 ℃,50-70r/min, and the fermentation culture is 36-48h.
8. The preparation method according to claim 7, wherein the complex enzyme comprises cellulase and ficin in a mass ratio of 5-7:2.
9. The process according to claim 4, wherein the mass ratio of the extract to the fermentation product in step S5 is 5-7:10-12.
10. The preparation method according to claim 4, comprising the following steps:
s1, weighing the raw materials according to a proportion, cleaning, drying and crushing to obtain mixed powder;
s2, adding the mixed powder prepared in the step S1 into water, wherein the solid-liquid ratio of the mixed powder to the water is 1: extracting at 5-10g/mL under boiling for 2-3 hr, filtering, and drying to obtain extract;
s3, respectively inoculating lactobacillus plantarum and bifidobacterium adolescentis into a Gao's culture medium, and performing activation culture for 18-24 hours at 36-38 ℃ and 50-70r/min to obtain strain seed liquid with the bacterial content of 10 8 -10 9 cfu/mL;
S4, adding filter residues obtained in the step S2 into sterile water, sterilizing, inoculating lactobacillus plantarum and bifidobacterium adolescentis strain seed liquid obtained in the step S3, wherein the inoculum size is 2-3% and 1-2% respectively, then adding 1-2% of complex enzyme by weight of the total mass of the system, fermenting and culturing at 36-38 ℃ for 36-48h at 50-70r/min, filtering, and freeze-drying to obtain a fermentation product;
the compound enzyme comprises cellulase and ficin with the mass ratio of 5-7:2;
s5, uniformly mixing 5-7g of the extract prepared in the step S2 and 10-12 g of the fermentation product prepared in the step S4 to prepare the bagged seasoned tea for treating gout.
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