CN116617297A - Traditional Chinese medicine foot-bath preparation and preparation method and application thereof - Google Patents
Traditional Chinese medicine foot-bath preparation and preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The application discloses a traditional Chinese medicine foot-bath preparation and a preparation method and application thereof. Provides a proper treatment method for the AR infants between 3 and 6 years old, adopts various natural Chinese herbal medicines as raw materials for differentiation of symptoms, can warm and tonify lung and kidney, dispel cold and dispel evil, improves the constitution of the infants due to lung deficiency and cold, and is safe and free from toxic and side effects.
Description
Technical Field
The application belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine foot-bath preparation and a preparation method and application thereof.
Background
Allergic rhinitis (allergic rhinitis, AR) in children is a common allergic disease mediated by IgE in childhood, mainly including runny nose, itching nose, nasal obstruction and sneeze, with the prevalence of AR in children in our country being 16% and increasing year by year. The repeated attack of the AR of the children can induce a plurality of complications, such as nasosinusitis, tympanitis and the like, and the long-term nasal obstruction and the need of opening mouth and breathing influence the development of jawbone and intelligence, thus seriously endangering the health of the children. The conventional clinical treatment methods of AR at present mainly comprise drug treatment, immunotherapy, surgical treatment, traditional Chinese medicine treatment and the like.
According to the suggestion of the diagnosis and treatment guidelines (2022, revised edition) of allergic rhinitis of children, the current western medicine uses antihistamine drugs, intranasal glucocorticoids and anti-leukotriene drugs as the main drugs for the drug treatment of children AR, and improves symptoms through local and systemic treatment, and the short-term curative effect is positive, but the control symptoms obviously depend on the drugs too much, the drug is easy to relapse after stopping, the curative effect of patients with longer course is poor, and adverse reactions are more, so that the parents of many children inevitably generate worry and conflict of drug administration. In recent years, the traditional Chinese medicine for treating children AR has the characteristics of obvious recent curative effect, stable long-term curative effect, less adverse reaction and the like, and is popular with parents of children. However, the traditional Chinese medicine decoction is time-consuming and has poor taste for most of children, especially for children before 3-6 years of school age, and the compliance is poor, so that the treatment method which can select effective prescription according to the constitution of the children and can overcome the difficulty of taking traditional Chinese medicines for children is an urgent problem.
Disclosure of Invention
This section is intended to outline some aspects of embodiments of the application and to briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section as well as in the description of the application and in the title of the application, which may not be used to limit the scope of the application.
The present application has been made in view of the above and/or problems occurring in the prior art.
Therefore, the application aims to overcome the defects in the prior art and provide a traditional Chinese medicine foot-bath preparation.
In order to solve the technical problems, the application provides the following technical scheme: a traditional Chinese medicine foot-bath preparation comprises the following components: ephedra, aconite root and asarum herb, according to mass percent, ephedra: radix Aconiti lateralis Preparata: asarum = 3-5:3-5:1-2.
The application further aims at providing a preparation method of the traditional Chinese medicine foot-bath preparation.
In order to solve the technical problems, the application provides the following technical scheme, namely a preparation method of a traditional Chinese medicine foot-bath preparation, which comprises the following steps: a preparation method of a traditional Chinese medicine foot-bath preparation comprises the following steps:
preparing raw materials: the preparation method comprises the following steps of: herba Ephedrae: radix Aconiti lateralis Preparata: herba asari;
crushing: pulverizing herba Ephedrae, radix Aconiti lateralis Preparata, and herba asari;
mixing: mixing the crushed raw materials and uniformly stirring to obtain a raw material of the foot-bath preparation;
and (3) packaging: and packaging the raw materials of the footbath preparation according to the proportion to prepare a finished product of the footbath preparation.
As a preferable scheme of the preparation method of the traditional Chinese medicine foot-bath preparation, the preparation method comprises the following steps: in the preparation raw materials, ephedra is prepared by mass: radix Aconiti lateralis Preparata: asarum = 3-5:3-5:1-2.
As a preferable scheme of the preparation method of the traditional Chinese medicine foot-bath preparation, the preparation method comprises the following steps: in the pulverizing, herba Ephedrae, radix Aconiti lateralis Preparata, and herba asari are pulverized to 100 mesh.
As a preferable scheme of the preparation method of the traditional Chinese medicine foot-bath preparation, the preparation method comprises the following steps: packaging to 10 g.
As a preferable scheme of the preparation method of the traditional Chinese medicine foot-bath preparation, the preparation method comprises the following steps: in the preparation raw materials, ephedra is prepared by mass: radix Aconiti lateralis Preparata: asarum = 4:4:1.
Another object of the application is to provide a reference to a traditional Chinese medicine foot-bath preparation.
In order to solve the technical problems, the application provides the following technical scheme, and the application of the traditional Chinese medicine foot-bath preparation comprises the following steps: the traditional Chinese medicine foot-bathing preparation is prepared by mixing boiling water uniformly and then adjusting the water temperature to 40 ℃.
As a preferable scheme of the application of the traditional Chinese medicine foot-bath preparation, the traditional Chinese medicine foot-bath preparation comprises the following components: the foot bath is to perform foot bath for 10 to 15 minutes after the water temperature is regulated to 40 ℃.
As a preferable scheme of the application of the traditional Chinese medicine foot-bath preparation, the traditional Chinese medicine foot-bath preparation comprises the following components: the foot massage is matched with the foot massage during the foot massage process.
The application has the beneficial effects that:
the application provides traditional Chinese medicine foot-bath powder for treating children allergic rhinitis, lung and kidney deficiency and cold syndrome and a use method thereof, and provides a proper treatment method for children suffering from AR of 3-6 years old.
Detailed Description
In order that the above-recited objects, features and advantages of the present application will become more apparent, a more particular description of the application will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application, but the present application may be practiced in other ways other than those described herein, and persons skilled in the art will readily appreciate that the present application is not limited to the specific embodiments disclosed below.
Further, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic can be included in at least one implementation of the application. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
In the embodiment of the application, the data processing is performed in the following manner: manually checking and recording each data, processing the data by using SPSS 18.0 statistical software package, wherein the metering data is expressed by (+/-s), and comparing the data among groups by using t-test; the counting data are expressed in terms of rate, the comparison among groups is analyzed by using chi-square test, and the difference of P < 0.05 is statistically significant.
Example 1
The embodiment is used for providing the preparation of the traditional Chinese medicine foot-bath preparation:
the raw materials are prepared according to the following weight ratio: herba Ephedrae: radix Aconiti lateralis Preparata: asarum is 4:4:1, a step of;
crushing: pulverizing herba Ephedrae, radix Aconiti lateralis Preparata, and herba asari to 100 mesh;
mixing: mixing the crushed raw materials and uniformly stirring to obtain a raw material of the foot-bathing preparation;
and (3) packaging: and subpackaging the footbath preparation according to the amount to obtain a finished footbath preparation.
Example 2
This example illustrates how to use the finished footbath formulation:
the footbath powder prepared in the example 1 is used in the following manner, and meanwhile, the same amount of clear water is used for comparison, when the footbath powder is used, a packaging bag is opened, 10g of the footbath powder is taken, the 10g of the footbath powder is added into 1-1.5 kg of boiling water, the mixture is stirred for 3-5 minutes, 3-4 kg of warm water is added to adjust the temperature to about 40 ℃, the footbath is carried out for 10-15 minutes, and parents can massage the soles of feet once a day during footbath.
The Western diagnosis standard is formulated with reference to the recommended diagnosis standard in the diagnosis and treatment guide for allergic rhinitis (2015, tianjin) formulated by the division of otorhinolaryngology of the Chinese medical society.
Dialectical standard of traditional Chinese medicine [2]: the differentiation standard of lung-kidney deficiency cold type refers to the formulation of the Chinese medicine treatment method and prescription.
The main symptoms are itching nose, frequent or sudden sneeze, clear nasal discharge, continuous nasal obstruction;
secondary symptoms, such as cold limbs, pale complexion, aversion to cold, preference for warmth and warmth, or body curling; clear urine or loose stool; pale tongue with white and moist coating or smooth tongue, or fat and tender tongue; the deep, slow and weak pulse or the deep, weak pulse.
The disease can be judged by having more than 2 main symptoms and secondary symptoms.
Treating autoimmune diseases such as congenital lupus erythematosus, ankylosing spondylitis, etc.; (2) patients with serious primary diseases such as heart, brain, lung, liver, hematopoietic system, etc.; (3) patients with severe skin allergy or severe skin crumple; (4) the child patient with poor compliance is excluded from the sample;
94 cases of children suffering from lung-kidney deficiency cold type allergic rhinitis are selected from 6 months 2020 to 2022, 51 cases of women and 43 cases of men; the ages are 3-6 years old, the average age is 4.3 years old, the treatment groups and the control groups are randomly divided according to a random digital table method, 47 cases of treatment groups and control groups are respectively, and the comparison difference of general data such as gender, age, disease course and the like of the two groups has no statistical significance (P is more than 0.05), so that the treatment groups and the control groups are comparable;
the observed group of infants was treated for footbath as in example 4, and the control group was treated orally with montelukast sodium chewable tablet alone. If the infant rhinitis is acute during the observation period, the western medicine is given with conventional medicine treatment. All children had an observation period of 3 months.
The oral treatment of the montelukast sodium chewable tablet is to take the montelukast sodium, and the specific usage is that the montelukast sodium particles are taken orally, 4mg each time, and 1 time a day.
Western medicine conventional medicine treatment adopted during polar onset of rhinitis is used for spraying the mometasone furoate nasal spray, the nose is sprayed 1 time a day in the morning, each time each nostril is sprayed 1 time, and the continuous use time is not more than 4 weeks; the loratadine syrup is administered orally, 5mg each time, 1 time a day, for a period of no more than 2 weeks.
For the two groups of patients, blood is drawn before and after treatment, serum is separated, the IFN-gamma and IL-4 levels of the serum are measured by ELISA, and the kit is purchased from Wohan valley biological medicine Co.
TABLE 1 serum IFN-gamma, IL-4 levels and IFN-gamma/IL-4 ratios in infants before and after treatment
As can be seen from Table 1, (1) serum IL-4 levels were significantly reduced (P < 0.05) in both the treated and control groups, and significantly reduced (P < 0.05) in the treated group as compared to the control group. (2) Serum IFN-gamma levels were increased (P < 0.05) in both the treated and control groups compared to the pre-treatment groups, with no significant difference (P > 0.05) between the two groups. (3) The IFN-gamma/IL-4 ratio is compared, the treatment group and the control group are obviously improved (P is less than 0.05) after treatment compared with the treatment before treatment, and the treatment group is obviously improved (P is less than 0.05) compared with the control group.
Table 1 shows that the finished footbath preparation provided in example 1 can actually improve the immunity level of cellular immunity and humoral immunity, so that the autoimmune level of the infant can be improved, and the treatment effect on the allergic rhinitis of the infant can be finally achieved.
Subjective evaluation comparison was performed according to the above treatments, and subjective evaluation comparison was performed before and after treatment at the end of 3 months after treatment, and the obtained data are shown in table 2.
The curative effect evaluation method comprises the following steps: efficacy assessment criteria: (refer to "diagnosis and treatment principle of allergic rhinitis and recommended protocol (2004, lan.))", the efficacy is evaluated according to symptom score, scoring method: (pre-treatment integral-post-treatment integral)/pre-treatment integral multiplied by 100%, more than or equal to 66% is effective, 26-65% is effective, less than or equal to 25% is ineffective.
Table 2 comparison of subjective and objective assessments before and after treatment
Note that: the comparison between the two groups adopts paired t test, and the comparison between the groups adopts rank sum test.
In table 2, at the end of 3 months after treatment, the rhinitis symptoms of both groups of patients are obviously improved compared with those before treatment, the difference has significance (P is less than 0.05), the treatment between the two groups is compared with that before and after treatment, Z= -2.648, P=0.012 is less than 0.05, and the treatment effect of the treatment group is better than that of the control group.
Table 2 shows that whether or not the footbath preparation provided in my application is used for footbath has a remarkable effect of improving rhinitis, and the experimenter using the footbath preparation provided in my application has more experience of improving rhinitis.
Allergic rhinitis (allergic rhinitis, AR) in children is a common allergic disease mediated by IgE in childhood, mainly including runny nose, itching nose, nasal obstruction and sneeze, is a common disease and frequently-occurring disease of paediatrics and otorhinolaryngology, and belongs to the category of 'allergic rhinitis' in traditional Chinese medicine.
The Chinese medicine considers that the allergic rhinitis patients are caused by specific intrinsic properties, viscera deficiency and qi accompanied by exogenous pathogenic factors. The pathogenesis of the cold type children's allergic rhinitis is kidney yang deficiency and cold sensation in lung channel, and the deficiency of kidney qi, qi failing to take hold of body fluids, kidney yang deficiency, qi failing to control, cold water invading nose, so that sneeze is continuous, nasal discharge is clear, lung qi deficiency cold causes abnormal dispersing and descending, body fluids are distributed and dysfunction, body fluids stop at nose, and nasal obstruction is manifested. Yang qi deficiency is in the interior and qi deficiency and exterior-defense are not firm, which is consistent with the feeble and feeble sensation of the Ma Huang Fu Xiao Tang.
The Mahuang Fuzi Manchurian wildginger decoction is from Zhang Zhongjing (Shang Han Lun) and consists of Mahuang, fuzi and Manchurian wildginger. Herba Ephedrae in the recipe has the effects of pungent and warm, inducing sweat, entering lung and bladder meridian, dispersing lung qi for dispelling cold and opening nasal orifices, and the lung qi is clear and smooth to promote body fluid circulation, so that symptoms and signs such as nasal discharge, mucous membrane swelling, turbinate swelling and the like can be relieved. The nasal position is the location where blood vessels gather and the location where clear yang meets, as in Ling-Pi-Xie visceral disease form: twelve main meridians, three hundred and sixty five collaterals, all of which are on the face and run out of the orifices … … and the pectoral qi is stinky from the nose. The lung qi is smooth and the qi of the lung is smooth, the meridians are smooth, and the nose can know the smell. Radix Aconiti lateralis Preparata has effects of warming kidney, supporting yang, and eliminating pathogenic factors. The kidney yang is abundant in the kidney, viscera, body and orifices can be warmed up, nutrient and defensive coordination is realized, invasion of exogenous evil is difficult, the kidney yang is sufficient, the opening and the closing are proper, and the symptom such as clear nasal discharge is eliminated when the water metabolism is normal. Asarum herb, herba asari, with its nature and flavor moving, enters lung and kidney meridians, and helps ephedra herb to relieve exterior syndrome, and helps aconite root to warm yang. The three medicines are combined together to warm yang and dispel cold, defend against the body heat and dispel evil, and achieve the curative effects of warming yang and dispelling haze. Modern medical researches also show that ephedra has the functions of regulating immunity and resisting allergy, and the cold dispelling effect of aconite can be understood as being related to the effects of enhancing immune system, easing pain, increasing blood oxygen and the like, and asarum has the functions of resisting histamine and allergic reaction.
The traditional Chinese medicine theory is that: the foot is the starting point of the three yin meridians and the ending point of the three yang meridians. The foot sole has more than 300 acupoints and 67 reflecting areas, which is a reduction of human body. Qi flowing out of the zang-fu organs and the combination of the interior and exterior should be an important part of the treatment of diseases. The lung is in the chest, and is externally combined with the fur, defending qi and consolidating superficial resistance, and is related to connective tissues through the lung meridian of hand taiyin. The sole of the foot is the mother-child relationship with the lung meridian (Jin Shuixiang) where the kidney meridian passes. According to the theory of meridians, the meridians are a multi-layered, multi-functional, multi-modal system of regulation and control, and the acupoints of the meridians have the sensitivity, amplification, storage and overall regulation to drugs. The traditional Chinese medicine foot bath is characterized in that the traditional Chinese medicine foot bath utilizes the principle of external treatment of internal diseases, combines the treatment and health care, baths the foot through liquid medicine with certain temperature, benign stimulation of nerve endings, sends feedback information through central nervous system regulation, promotes the operation of air and blood, warms viscera, dissipates cold and relieves exterior syndrome, and has the characteristics of convenience and effectiveness.
It should be noted that the above embodiments are only for illustrating the technical solution of the present application and not for limiting the same, and although the present application has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present application may be modified or substituted without departing from the spirit and scope of the technical solution of the present application, which is intended to be covered in the scope of the claims of the present application.
Claims (9)
1. A traditional Chinese medicine foot-bath preparation is characterized in that: comprises the following components: ephedra, aconite root and asarum herb, according to mass percent, ephedra: radix Aconiti lateralis Preparata: asarum = 3-5:3-5:1-2.
2. A preparation method of a traditional Chinese medicine foot-bath preparation is characterized by comprising the following steps: the method comprises the following steps:
preparing raw materials: the preparation method comprises the following steps of: herba Ephedrae: radix Aconiti lateralis Preparata: herba asari;
crushing: pulverizing herba Ephedrae, radix Aconiti lateralis Preparata, and herba asari;
mixing: mixing the crushed raw materials and uniformly stirring to obtain a raw material of the foot-bath preparation;
and (3) packaging: and packaging the raw materials of the footbath preparation according to the proportion to prepare a finished product of the footbath preparation.
3. The method for preparing the traditional Chinese medicine foot-bath preparation according to claim 2, which is characterized in that: the preparation raw materials comprise, by mass, ephedra: radix Aconiti lateralis Preparata: asarum = 3-5:3-5:1-2.
4. The method for preparing the traditional Chinese medicine foot-bath preparation according to claim 2, which is characterized in that: in the crushing, ephedra, aconite and asarum are crushed to 100 meshes.
5. The method for preparing the traditional Chinese medicine foot-bath preparation according to claims 2-4, which is characterized in that: the package was 10 g.
6. The method for preparing the traditional Chinese medicine foot-bath preparation according to claims 2-4, which is characterized in that: the preparation raw materials comprise, by mass, ephedra: radix Aconiti lateralis Preparata: asarum = 4:4:1.
7. An application of a traditional Chinese medicine foot-bath preparation is characterized in that: the traditional Chinese medicine foot-bath preparation is prepared by uniformly mixing boiling water and then adjusting the water temperature to 40 ℃.
8. The use of a traditional Chinese medicine footbath preparation according to claim 6, wherein: the footbath is performed for 10-15 min after the water temperature is regulated to 40 ℃.
9. The use of a traditional Chinese medicine footbath preparation according to claim, wherein: the foot massage process is matched with foot massage.
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Non-Patent Citations (2)
| Title |
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| 王树鹏: "麻黄细辛附子汤对变应性鼻炎T淋巴细胞亚群的影响", 辽宁中医杂志, vol. 29, no. 09, pages 562 - 563 * |
| 稼轩 桐君: "用泡脚、药浴等方法治小儿感冒咳嗽", pages 1 - 4, Retrieved from the Internet <URL:https://mp.weixin.qq.com/s?__biz=MzA5Mjk1NDE1Ng==&mid=2651409497&idx=1&sn=cd6bef3e5bcbf1afca7c2e88baa701f6&chksm=8b98a71abcef2e0ca69d037896f0bb2053bcb9ebd20853f31cee051d73268d54e59bd642da5e&scene=27> * |
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