CN102049033A - Medicament for intervention treatment of chronic obstructive pulmonary disease and preparation method thereof - Google Patents
Medicament for intervention treatment of chronic obstructive pulmonary disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an improved mustard plaster applied on an acupuncture point for intervention treatment of a chronic obstructive pulmonary disease and a preparation method and an application thereof, belonging to the technical field of treatment through combination of traditional Chinese medicine and Western medicine. The medicament for intervention treatment of the chronic obstructive pulmonary disease is characterized by comprising the following raw materials in parts by weight: 1-2 parts of manchurian wildginger, 1-1.5 parts of white mustard seed, 1-1.5 parts of gansui root, 0.5-1.5 parts of rhizoma corydalis, 0.2-0.6 part of cassia bark, 0.2-0.6 part of flos caryophyllata, 0.1-0.3 part of Szechuan pepper, 0.1-0.2 part of borneol, 0.003-0.005 part of anisodamine, 0.003-0.005 part of chlorpheniramine and 3-5 parts of fresh ginger juice. Compared with the prior art, the medicament provided by the invention has the following advantages: combining the traditional Chinese medicine with the Western medicine, respectively playing the effects, treating both manifestation and root cause of the disease, being convenient for administration, being fast in onset of action and having small side effects. The medicament can effectively reduce airway hyperresponsiveness, control occurrence and development of the condition of the disease and alleviate clinical symptoms.
Description
Technical field
The point application that the present invention relates to a kind of therapeutic intervention chronic obstructive pulmonary disease improves hot mustard cream and its production and application, belongs to the therapy of combining Chinese and Western medicine technical field.
Background technology
Chronic obstructive pulmonary disease (COPD) number of patients is many, the mortality rate height, and social economy's burden is heavy, has become an important public health problem.Since this disease more than the middle age with sequela, along with the development of social senilization, the COPD preventing and controlling also have been subjected to the attention of countries in the world.In the world, COPD occupies the 4th of the current cause of death.According to the research that the World Bank and World Health Organization (WHO) deliver, will become the 5th of world's disease financial burden to the year two thousand twenty COPD.In China, COPD is the important chronic respiratory system diseases of serious harm people health equally, according to recently to China the north and rural area, middle part (Liaoning, Hubei, Beijing) 102230 census of population that grow up, COPD accounts for 3% of population more than 15 years old, the Beijing area is up to 4.5%, COPD patient estimates have 2,500 ten thousand approximately among the whole nation 15 years old and the above crowd, breathe the rural area is the 1st that sick mortality rate accounts for the various causes of the death, the annual number because of COPD death in the whole nation reaches 1,000,000, the number that disables reaches 500-1000 ten thousand, occupies the 1st of China's disease burden sequence.The mankind enter 21st century, and along with China's arriving in aged epoch, COPD will become the one of the main reasons of person in middle and old age's death and disability.Just sent the call of " actively preventing and treating chronic bronchitis " we Premier Zhou Enlai that loves and respects in 1971, and proposed " will catch the end to the work one that prevents and treats chronic bronchitis ".The Chinese government early classifies this research as " eight or five ", " 95 " key research projects.Since the seventies, though China has obtained very great achievement to the control of chronic bronchitis inflammation, the result is still unsatisfactory, and a crucial reason is not catch at all, for a long time the emphasis of research mainly is placed in the control of pulmonary heart disease, and the early prevention and treatment of COPD is lacked enough understanding.In case tangible symptom appears in the patient, treat just now when developing into III level COPD (pulmonary heart disease), late.Many of clinicians are satisfied with COPD acute exacerbation phase patient are treated, and to the control of stable phase with instruct the treatment of patient's self-rehabilitation to lack necessary attention.Because how III level COPD patient loses self care ability to some extent, need nursing for a long time and look after, so also bring out immeasurable family and social problem.Therefore the control of actively developing COPD has great importance.In April, 1998, The World Health Organization (WHO) and U.S.'s cardiopulmonary Blood Research Institute (NHLBI) just propose COPD in the global strategy special topic investigation work report of diagnosis, treatment and the prevention of implementing summary COPD study on prevention emphasis will be placed on early discovery, the early prevention and treatment.
COPD is to be feature with the incomplete reversibility flow limitation of air flue, and is gradual disease, is the reaction of pulmonary to the unusual inflammation of deleterious particle or gas.COPD more than the middle age with sequela, reason be human immune system's function with advancing age and weak, hypoadrenocorticism after the middle age especially, larynx hyporeflexia, lung are inhaled the road defense function and are gone down, caused should disease generation; Smoking can make the bronchiolar epithelium cilium shorten, irregular, ciliary movement generation obstacle weakens the engulfing of alveolar phagocyte, sterilization functions, causes bronchospasm, increases airway resistance; Some chemical substance, organic dust and irritated proper energy increase airway reactivity, also stimulate bronchial mucosa, make air flue remove the function sustain damage, for bacterial invasion creates conditions.Respiratory tract infection is the major reason of COPD morbidity and aggravation.
Primary disease belongs to sick categories such as cough, the syndrome of dyspnea, phlegm retention in motherland's medical science.As " element is asked. declare five gas opinion " and cloud: " disorder of the lung giving rise to cough "; One piece of " element is asked " special train " coughing opinion " has proposed the famous argument of " vital organs of the human body all make us coughing, and not merely lung also ".In conjunction with clinical characters, the traditional Chinese medical science is divided into standard card and assertive evidence with primary disease, this is observed case and all selects the COPD stable phase, this phase, patient was based on assertive evidence, and most patient has lung spleen kidney yang QI-insufficiency sign in various degree (even patient does not have special clinical manifestation, certain adrenal cortex function deficiency to be arranged also, be potential suffering from a deficiency of the kidney), have phlegm-damp concurrently not to the greatest extent, medication focuses on strengthening the body resistance, the double surplus heresy of dispelling.
The diagnosis of COPD is summed up in enforcement according to NHLBI/WHO, the global strategy of treatment and prevention, and effectively the COPD processing target is the progress that wards off disease, relief of symptoms improves motor capacity and health status, prevents and treats complication and acute exacerbation, the reduction mortality rate.Therefore, in control, except giving up smoking, reduce the state of an illness and show effect repeatedly, improve patient's resistance against diseases, the outstanding phase prevents that in cold season autumn and winter that the state of an illness is sent out well the pulmonary respiration road from infecting, and the infringement that alleviates pulmonary function is particularly important.In recent years; what our research summary went out chronic obstructive pulmonary disease in practice prevents and treats style and characteristic; in chronic obstructive pulmonary disease; doctor trained in Western medicine and therapy of combining Chinese and Western medicine present situation; studied the clinical treatment progress that chronic obstructive pulmonary disease is prevented and treated rule and curative effect from multi-angle; on this basis; to the chronic obstructive pulmonary disease stable phase 0 grade has been proposed; I level and II A level (being called the chronic bronchitis catabasis in the past) patient carry out the clinical intervention treatment; mainly be to carry out " treating winter disease in summer " according to the Therapeutic Principle that motherland's medical science " is taken stopgap measures in (lung) when sending out; (kidney) at ordinary times effects a permanent cure "; its purpose is exactly that the control of COPD is focused in early days; as before a large amount of manpower and materials are not placed on one's body the patients with cor pulmonale; target is exactly a premorbid in the winter time; improve patient's body's immunity; strengthen resistance against diseases, prevent or alleviate increasing the weight of of the state of an illness, adequately protect pulmonary function; improve the patient health state, reduce complication and mortality rate.Walk one " road of chronic obstructive pulmonary disease control with Chinese characteristics ".And according at random the contrast principle observe, obtained clinical effectiveness preferably.
Summary of the invention
Technical problem to be solved by this invention is the new method of developing and designing at the chronic obstructive pulmonary disease therapeutic intervention, provide medicine of a kind of eutherapeutic combination of Chinese and Western medicine therapeutic intervention chronic obstructive pulmonary disease and preparation method thereof for Patients with Chronic Obstructive Pulmonary Disease, the new visual field of broadening treatment chronic obstructive pulmonary disease.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is as follows:
A kind of medicine of therapeutic intervention chronic obstructive pulmonary disease, its special character is: described medicine comprises the raw material of following weight portion:
Herba Asari 1-2 part, Semen Sinapis Albae 1-1.5 part, Radix Kansui 1-1.5 part, Rhizoma Corydalis 0.5-1.5 part, Cortex Cinnamomi 0.2-0.6 part, Flos Caryophylli 0.2-0.6 part, Fructus Zanthoxyli 0.1-0.3 part, Borneolum Syntheticum 0.1-0.2 part, Anisodamine 0.003-0.005 part, the quick 0.003-0.005 part of Piao Er, fresh ginger juice 3-5 part.
Manufacturing method for above mentioned medicine, its special character is may further comprise the steps:
A, get various raw materials according to described weight portion;
B, Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum are carried out dried, be ground into 200 purpose medicated powder, described medicine is become powder with 200 mesh sieve powder;
C, Anisodamine and Piao Ermin are ground not;
D, to get fresh ginger juice standby.
E, the powder that Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum sieve powder are become mix with the powder that Anisodamine and Piao Ermin are ground into, and stir, and use fresh ginger juice furnishing thick paste shape then, are the hot mustard cream of improvement.
Improve hot mustard cream point application in dog days method, be the traditional medical theory that reaches " preventing diseases instead for the treatment of diseases " according to Huangdi's Internal Classics " taking good care of YANG in spring and summer; taking good care of YIN in autumn and winter ", " midnight-noon and ebb-flow doctrine; open the cave " and " correspondence between man and universe theory " " people and day coherent are also; also corresponding with life " in good time, think to be the most vigorous time of yang-energy in 1 year in dog days of the lunar calendar especially in summer, the yang-energy of taking good care of the people at this moment with prevent from easily to fall ill in the winter time, increase the weight of the syndrome of dyspnea and winter flu, be the best opportunity.Be excess of YIN leading to deficiency of YANG winter, and the physiological function of human body changes, and winter climate cold is shunk human vas in addition, and blood flow is slack-off, and immunologic function degression can bring out COPD and fall ill winter; Summer, men outnumbered women, and immune function of human body improves, the cough with asthma remission.Improve hot mustard cream point application in dog days, therapeutic intervention cough with asthma card in advance to alleviate or to eliminate the symptom and the state of an illness when showing effect in the winter time, promotes the rehabilitation that cough with asthma is demonstrate,proved.The yang-energy in 1 year is spring and summer, and the yang-energy of spring and summer is heat " dog days ", " dog days " yang-energy period of great prosperity, medicine among the hot sun of selection temperature compensation, select the positive cave (three sun unifications) of conception vessel and governor vessel in addition, carry out " treating winter disease in summer ", be intended to excite yang-energy,, make the body yang-energy fill Sheng through gas, YIN and YANG in a relative equilibrium, strengthening vital QI to eliminate pathogenic factors, treatment must aim at the pathogenesis of disease, thus reach the purpose that control cough with asthma card recurs." coldest days of winter " adopt QI invigorating tonifying YANG, the damp eliminating medicine that reduces phlegm, and stick in lung spleen kidney three on Yu cave, pass by skin, meridians and annotate, and make medicine directly affact retained phlegm (old complaint) part of hiding, and it is dispeled, and reach the purpose of " treatment must aim at the pathogenesis of disease ".But using modified hot mustard cream dog days carry out point application (bilateral fei shu, Hsinshu (acupoint), GEYU acupoint) summer stimulating acupoint generation effect, medicine is penetrated in the subcutaneous tissue cell, impel local skin vasodilation, blood circulation promoting has expelling pathogenic wind from the body surface, cold expelling, warming the lung, dissipating fluid-retention, cough-relieving, relievings asthma, leads to effects such as QI and blood regulating, strengthening spleen, tonifying kidney.Selected medicine focuses on Xin Wen and goes into lung meridian, Semen Sinapis master cold relieving expectorant, warming the lung promoting the circulation of QI in the side; The hot temperature of loosing of its property of Rhizoma Corydalis is logical, and the merit of blood-activating and qi-promoting is arranged; The hot warm expelling wind and cold of Herba Asari, warming the lung to resolve fluid-retention can be dispelled in the heresy of table, again can temperatureization at the cold-phlegm of lining; Though the Radix Kansui abnormal smells from the patient is bitter and sweet cold, its non-its medicine of function that rushes down chest and diaphragm knot water can substitute; Cortex Cinnamomi, the Fructus Zanthoxyli warming middle-JIAO is supporing yang; Flos Caryophylli, Borneolum Syntheticum promoting the circulation of QI are had one's ideas straightened out; Its slightly warm in nature of Rhizoma Zingiberis Recens, acrid in the mouth, function warming the lung for resolving phlegm sending down the abnormal ascending QI, though get its juice, flavor efficacy does not lose and all medicines and play the merit of calming down cough with asthma.Modern medicine study confirms, quick property and enlarge-effect outside the cave has medicine, channel system is low-resistance operation path, medicine sticks in zones such as special acupuncture points, can produce stronger drug influence at corresponding histoorgan rapidly, plays single-phase or the two-phase regulating action, improve the immunologic function of human body, enhance metabolism, can make the body desensitization, improve pulmonary function and physical condition.After medicine is absorbed by blood vessel, lymphatic vessel through skin, can activate body immune system, the enhancing body defence capability, make it produce some specific antibody or start some active substance on lung surface and bring into play the effect of curing the disease, measure IgA, IgG in the serum, IgM after the medication and raise, IgE and eosinophilic granulocyte all reduce.Blood plasma cortisol has the raising of highly significant, illustrates that this law can make the HPA systemic-function improve.On the basis of traditional remedies, add with Anisodamine and Piao Ermin and make the hot mustard cream of improvement, to increase curative effect of medication.This had both inherited the characteristic of successive dynasties Chinese medicines, had brought into play the advantage and the effect of modern medicine again.The expansible local skin blood vessel of Anisodamine is easy to drug absorption, and the bronchospasm of releasing function is arranged; Chlorphenamine can reduce the local excitation of Chinese medicine medicine, and plays the effect of desensitization and cough-relieving.Point application also can be played therapeutical effect during morbidity, is used for the cold-phlegm standard card more.Clinical practice proves, this side constantly can relief of symptoms, and can improve the ability of body disease-resistant, and this therapy is a kind ofly both to take stopgap measures the Therapeutic Method that effects a permanent cure again.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: the combination of Chinese and Western medicine, respectively execute its effect, and treating both the principal and secondary aspects of a disease, medication is convenient, instant effect, side effect is little.Can effectively reduce the high response of air flue, clinical symptoms is alleviated in the generation of disease controlling and development.
The specific embodiment
Below provide the specific embodiment of the present invention, be used for that the present invention is further illustrated.
Embodiment 1
A kind of medicine of therapeutic intervention chronic obstructive pulmonary disease, raw material comprises: 1 jin of Herba Asari, 1 jin of Semen Sinapis Albae, 1 jin of Radix Kansui, 0.5 jin of Rhizoma Corydalis, 0.2 jin of Cortex Cinnamomi, 0.2 jin of Flos Caryophylli, 0.1 jin of Fructus Zanthoxyli, 0.1 jin of Borneolum Syntheticum, 0.003 jin of Anisodamine, quick 0.003 jin of Piao Er, 3 jin of fresh ginger juice.
Embodiment 2
A kind of medicine of therapeutic intervention chronic obstructive pulmonary disease, raw material comprises: Herba Asari 1.5g, Semen Sinapis Albae 1.2g, Radix Kansui 1.2g, Rhizoma Corydalis 1g, Cortex Cinnamomi 0.4g, Flos Caryophylli 0.4g, Fructus Zanthoxyli 0.2g, Borneolum Syntheticum 0.15g, Anisodamine 0.004g, the quick 0.004g of Piao Er, fresh ginger juice 4g.
Embodiment 3
A kind of medicine of therapeutic intervention chronic obstructive pulmonary disease, raw material comprises: 2 parts of Herba Asaris, 1.5 parts of Semen Sinapis Albaes, 1.5 parts of Radix Kansuis, 1.5 parts of Rhizoma Corydalis, 0.6 part of Cortex Cinnamomi, 0.6 part of Flos Caryophylli, 0.3 part of Fructus Zanthoxyli, 0.2 part of Borneolum Syntheticum, 0.005 part of Anisodamine, quick 0.005 part of Piao Er, 5 parts of fresh ginger juice.
The medicine of the foregoing description prepares according to following steps:
A, get various raw materials according to described weight portion;
B, Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum are carried out dried, be ground into 200 purpose medicated powder, described medicine is become powder with 200 mesh sieve powder;
C, Anisodamine and Piao Ermin are ground not;
D, to get fresh ginger juice standby.
E, the powder that Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum sieve powder are become mix with the powder that Anisodamine and Piao Ermin are ground into, and stir, and use fresh ginger juice furnishing thick paste shape then, are the hot mustard cream of improvement.
More than the using method of three prepared medicines of embodiment:
The patient rides backwards on chair, two handss are filled the span of a man's arms and are put on the chair back, expose the back, get the hot mustard cream of improvement directly through the medicine cake of 1.5cm, thick 0.5cm size, be applied to both sides, back fei shu, Hsinshu (acupoint), ke shu six caves, fix it, removed in 5-10 hour (deciding) according to individual physique, skin with SHANGSHI ZHITONG GAO (Tianjin Tongrentang Pharmaceutical Factory's product), at the beginning of annual summer, in, volt does not respectively paste continuous 3 years 1 time.Paste that the back is local rubescently itches or play a red little rash and need not handle, indivedual case skins bubble, and available Gentian Violet liquid medicine is coated with it.The viewing duration person that has the acute exacerbation, its treatment is identical with matched group.
All carry out clinical indices observation and lab index observation before receiving treatment and after finishing the course of treatment.
Clinical indices is observed: before and after the each patient treats all to coughing, expectorant, breathing heavily with the degree and the flu situation of wheezing sound and observe.
Lab index is observed: all suck before the each patient treats and carry out pulmonary function test (pft) 3 times after ventolin inhaler 200ug (GlaxoSmithKline PLC company) had a rest 15 minutes, get its meansigma methods, as the lung function index before the treatment; Treatment finishes the back, and to carry out the pulmonary function test (pft) method annual winter the same, gets 2 annual averages and be treatment back pulmonary function.The pulmonary function test (pft) of this research has been used the FGC-A spirometer that peace microelectronics Science Institute produces.Statistical observation is carried out in variation to index.
Relatively adopt t check between statistical procedures four sample averages, rate relatively adopts X in each group and between group
2Check, there is statistical significance P＜0.05.
Efficacy assessment standard: the efficacy assessment standard of this research observation group and matched group is all evaluated according to the curative effect judging standard of national chronic bronchitis clinical speciality in 1979 meeting (Guangzhou) revision.
1. clinical cure: stop using and suit the medicine to the illness the medicine treatment after 2 years, cough, expectorant, asthma shape takes a turn for the better more than ninety percent, or clinical symptoms and all not enough slightly person of pulmonary's wheezing sound.2. produce effects: cough, expectorant, asthma shape passs on more than sixty percent well, or symptom and pulmonary's wheezing sound be clearly better (+++→+).3. take a turn for the better: cough, expectorant, asthma shape takes a turn for the better more than three one-tenth, or symptom and pulmonary's wheezing sound take a favorable turn (+++→ ++ or ++ →+).4. invalid: stable disease is simple or see the person of increasing the weight of through two Winter-Springs treatment state of an illness is counter.
Contrast test: 0 grade of 400 example of this research, I level and II A level COPD stable phase patient (this phase of the traditional Chinese medical science is based on assertive evidence), its diagnosis all meets the diagnosis and the grade scale of " global strategy of the diagnosis of chronic obstructive pulmonary disease, treatment and prevention is implemented to sum up " that U.S.'s cardiopulmonary Blood Research Institute and World Health Organization (WHO) work out in April, 1998 meeting.0 grade: FEV
1＞80%, FEV
1/ FVC＞70% has chronic sympton (cough, expectoration) I level: FEV
1〉=80%, FEV
1Chronic sympton (cough, expectoration) is accompanied or do not accompanied to/FVC＜70%; IIA level: FEV
1/ FVC＜70%, 50%≤FEV
1Chronic sympton (cough, expectoration, dyspnea) is accompanied or do not accompanied to＜80% predicted value.
With 400 routine Patients with Chronic Obstructive Pulmonary Disease, select 100 examples at random as observation group 1, select 100 examples at random as observation group 2, select 100 examples at random as observation group 3, other 100 examples are organized in contrast.
100 routine patients in the observation group 1, male 52 examples, women 48 examples; Age 31-63 year; Course of disease 2-12.Use the embodiment of the invention 1 prepared medicine and treat according to above Therapeutic Method.
100 routine patients in the observation group 2, male 47 examples, women 53 examples; Age 33-67 year; Course of disease 3-13.Use the embodiment of the invention 2 prepared medicines and treat according to above Therapeutic Method;
100 routine patients in the observation group 3, male 55 examples, women 45 examples; Age 31-65 year; Course of disease 2-10.Use the embodiment of the invention 3 prepared medicines and treat according to above Therapeutic Method.
100 routine patients in the matched group 4, male 46 examples, women 54 examples; Age 29-67 year; Course of disease 3-11.Matched group is in symptomatic treatment methods such as acute exacerbation phase reasonable application of antibiotics, beta 2 receptor agonist, anticholinergic agents, theophylline class medicine, oxygen uptake, suction expectorant.Stable phase need not any medicine.
All carry out pulmonary function test (pft) before four groups of clinical data treatments, with the objective indicator of following three indexs of lung function tests as COPD classification and observation of curative effect.Promptly the 1st second forced expiratory volume (FEV
1) measured value/predicted value percentage ratio, forced vital capacity (FVC) and 1 second rate (FEV
1/ FVC).All data are with mean ± standard deviation (X ± S) expression, relatively adopt the t check between mean, learn by statistics and handle zero difference (P＞0.05), four groups of patients are basic identical in sex, age, the COPD course of disease, male's smoking index (every day average number of smoking * smoking year number) and each basic lung function parameter, have comparability.See Table 1.
Data comparison before four groups of cases treatments of table 1 (X ± S)
Annotate: four groups of every indexs compare zero difference (P＞0.05).
Use the observation on pulmonary function of above medicine to the results are shown in Table 2-4:
FEV before and after four groups of treatments of table 2
1The variation of % predicted value (X ± S)
Annotate: FEV before and after (1) 0 grade of patient treatment
1Decline matched group and observation group be (P＜0.05) obviously.
(2) I level patient treatment cross-reference group FEV
1Decline is than observation group obvious (P＜0.05).
(3) compare matched group FEV before and after the IIA level patient treatment
1% descends, and there were significant differences (P＜0.05) than observation group.
FVC (L) variation before and after four groups of treatments of table 3 (X ± S)
Annotate: matched group FVC descends than observation group obvious (P＜0.05) among (1) 0 grade of patient.
(2) compare before and after observation group and the treatment of control group among the I level patient, matched group FVC descends than observation group obvious (P＜0.05).
(3) compare before and after observation group and the treatment of control group among the IIA level patient,, matched group FVC descends than observation group obvious (P＜0.05).
FEV before and after four groups of treatments of table 4
1/ FVC (%) variation (X ± S)
Annotate: the 1 second rate decline matched group in treatment front and back is than observation group obvious (P＜0.05) among (1) 0 grade of patient.
(2) the change observation group and the matched group of the 1 second rate in treatment front and back relatively do not have significant difference (P＞0.05) among the I level patient.
(3) the change observation group and the matched group of the 1 second rate in treatment front and back relatively do not have significant difference (P＞0.05) among the IIA level patient.
From above three tables of data as can be seen, FEV before and after observation group and treatment of control group
1The % predicted value, FVC, FEV
1The result of/FVC shows, the FEV of observation group in 0 grade, I level and II A level COPD patient
1Change before and after % predicted value and the FVC treatment is compared with the change before and after the above-mentioned every index treatment of matched group, and there were significant differences, illustrates that observation group can improve pulmonary ventilation effectively; The FEV of observation group and matched group in I level and II A level COPD patient
1The change no significant difference that/FVC changes, and FEV among 0 grade of COPD patient
1The decline of/FVC, observation group is obvious than matched group, and early intervention treatment more is described, the easy more control of the state of an illness, effect is good more.
Use above clinical drug sings and symptoms observed result to see Table 5:
Four groups of curative effects of table 5 relatively
Annotate: observation group and matched group be P＜0.05 relatively.
From above three tables of data as can be seen:
In the 100 routine cases of observation group 1, clinical cure 20%, produce effects 50% takes a turn for the better 23%, and is invalid 7%, total effective rate 93%; From the relation of classification and curative effect, the curative effect of 0 grade of sufferer of the embodiment of the invention 1 prepared Drug therapy is better than the I level, and I level curative effect is better than 0 grade of patient of II A level totally 35 examples, all obtains good efficacy, clinical cure 17 examples wherein, produce effects 17 examples; Clinical symptoms has all obtained basic controlling, and positive effect is arranged.
In the 100 routine cases of observation group 2, clinical cure 22%, produce effects 48% takes a turn for the better 22%, and is invalid 8%, total effective rate 92%; From the relation of classification and curative effect, the curative effect of 0 grade of sufferer of the embodiment of the invention 2 prepared Drug therapys is better than the I level, and I level curative effect is better than II A level; 0 grade of patient is totally 35 examples, all obtains good efficacy, clinical cure 18 examples wherein, produce effects 17 examples; Clinical symptoms has all obtained basic controlling, and positive effect is arranged.
In the 100 routine cases of observation group 3, clinical cure 20%, produce effects 48% takes a turn for the better 24%, and is invalid 8%, total effective rate 92%; From the relation of classification and curative effect, the curative effect of 0 grade of sufferer of the embodiment of the invention 3 prepared Drug therapys is better than the I level, and I level curative effect is better than II A level; 0 grade of patient is totally 32 examples, all obtains good efficacy, clinical cure 16 examples wherein, produce effects 15 examples; Clinical symptoms has all obtained basic controlling, and positive effect is arranged.
Observation group and matched group are after treatment, and observation group's total effective rate is 92.33%, and the matched group total effective rate is 61%, and observation group obviously is better than matched group, and curative effect is learned to handle more by statistics significant difference.Therefore, use drug therapy systems scleroderma that the embodiment of the invention makes curative effect effectively preferably.
COPD stable phase (I level and II level A) is many based on assertive evidence, and general many employing treatments by Chinese herbs are main or use bronchodilator as required and suck glucocorticoid that with the warming the lung strengthening spleen, tonifying kidney, human body immunity improving power is improved pulmonary ventilation, prevents the outbreak of COPD.The point application of the hot mustard cream of this utilization improvement, COPD stable phase " treating winter disease in summer " clinical intervention is treated, pulmonary function test (pft) shows also can improve pulmonary ventilation effectively, obviously reduce times of common cold and alleviate cold symptoms, explanation is carried out " treating winter disease in summer " to COPD stable phase patient, can effectively prevent outbreak and relief of symptoms.Especially to 0 grade of high-risk period patient clinical cure rate height; remission is obvious; pulmonary function test (pft) pulmonary ventilation fall is few; can effectively protect pulmonary ventilation function; and I level patient's curative effect is lower than 0 grade; II level A patient's curative effect is lower than the I level, illustrates should catch early stage this crucial opportunity to the control of COPD.When carrying out " treating winter disease in summer ",, should note following problem to bringing out factors such as this onste:
1, strengthen labour protection is improved environmental sanitation, and eliminates the stimulation of harmful gass such as harmful smog, dust to respiratory tract, has smoking hobby person to give up smoking.
2, strengthen physical training disease resistance enhancemen.As adhere to running, take a walk, practise taijiquan or practise the qigong; Carry out cold resistant training.
3, in time pathogenic QI in the body such as treatment flu is waited and is turned cold and the flu of suffering from cold is the basic inducement that causes acute attack, so treatment is in time caught a cold and to effect a radical cure upper respiratory tract infection such as rhinitis, pharyngolaryngitis, chronic tonsillitis significant to preventing this onste.
4, preventing cold generation primary disease deficiency of both the splenic and pulmonary QI, a little less than the resistance against diseases, the flu of very easily suffering from cold, so essential factor time increase and decrease clothing, careful anti-exopathogen is invaded; Indoor often maintaining the circulation of air and solar radiation; Do not eat irritable food usually, avoid fatigue or sexual life especially too; Often massage tsu san li, Yingxiang, the sun, Baihui acupoint gently.Can control the generation of flu effectively.
Although 5, education patient education itself can not improve motor capacity or pulmonary function, it is dealt with in improvement has certain effect aspect ability, skill and the health status of disease, and as smoking cessation, self management's technical ability helps to alleviate dyspneic strategy etc.
Case 1, patient, the woman, 33 years old, ictal cough, expectoration 4 years, annual morbidity in winter is often brought out because of flu and is increased the weight of.Treatments such as normal oral antibiotic, antitussive and aminophylline, but symptom increases the weight of year by year, attack times is more and more, begins to accept this therapy in May, 2007, follow-up observation after 3 years, and patient's symptom is recurrence more, and times of common cold obviously reduces.
Case 2, patient, the man, 36 years old, smoking history is arranged, suffered from chronic obstructive pulmonary disease 8 years, cough, expectoration during outbreak, breathe hard, evening is heavier, be difficult to flat crouch sleeping, dizziness on daytime, feeling of fullness in the head, listless, it is limited to work.By smoking cessation, begin to accept 1 course of treatment of this therapy, cough, expectoration obviously alleviate, and attack times obviously reduces, and symptom is obviously lighter during outbreak, and symptom is controlled substantially, can be competent at all work.Quality of life improves.
Case 3, patient, the woman 49 years old, suffered from chronic obstructive pulmonary disease 11 years.Accepted this therapy for treating 3 years, cough, expectoration still arranged, but cough, expectoration, uncomfortable in chest, breathe hard and all take a favorable turn, lighter before the symptom ratio was received treatment when the follow-up observation patient stated outbreak, times of common cold also reduces, attack times also reduces, and can be engaged in general housework.Need to cooperate antibiotic and preventing phlegm from forming and stopping coughing medicine to help to keep treatment at ordinary times.
Claims (2)
1. the medicine of a therapeutic intervention chronic obstructive pulmonary disease, it is characterized in that: described medicine comprises the raw material of following weight portion:
Herba Asari 1-2 part, Semen Sinapis Albae 1-1.5 part, Radix Kansui 1-1.5 part, Rhizoma Corydalis 0.5-1.5 part, Cortex Cinnamomi 0.2-0.6 part, Flos Caryophylli 0.2-0.6 part, Fructus Zanthoxyli 0.1-0.3 part, Borneolum Syntheticum 0.1-0.2 part, Anisodamine 0.003-0.005 part, the quick 0.003-0.005 part of Piao Er, fresh ginger juice 3-5 part.
2. manufacturing method for above mentioned medicine is characterized in that may further comprise the steps:
A, get various raw materials according to described weight portion;
B, Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum are carried out dried, be ground into 200 purpose medicated powder, described medicine is become powder with 200 mesh sieve powder;
C, Anisodamine and Piao Ermin are ground not;
D, to get fresh ginger juice standby.
E, the powder that Herba Asari, Semen Sinapis Albae, Radix Kansui, Rhizoma Corydalis, Cortex Cinnamomi, Flos Caryophylli, Fructus Zanthoxyli, Borneolum Syntheticum sieve powder are become mix with the powder that Anisodamine and Piao Ermin are ground into, and stir, and use fresh ginger juice furnishing thick paste shape then, are the hot mustard cream of improvement.
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|---|---|---|---|---|
| CN103110702A (en) * | 2013-03-08 | 2013-05-22 | 刘清池 | Navel-warming paste capable of warming spleen and stomach for dispelling cold and preparation method thereof |
| CN103830703A (en) * | 2014-03-07 | 2014-06-04 | 河南中医学院 | Acupoint patch for treating cold pain |
| CN104906207A (en) * | 2015-07-02 | 2015-09-16 | 昆明市中医医院 | External treatment drug for preventing chronic obstructive pulmonary disease from attacking and preparation method of external treatment drug |
| CN114209804A (en) * | 2021-11-29 | 2022-03-22 | 德阳市中西医结合医院 | Navel patch for treating chronic obstructive pulmonary disease |
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2010
- 2010-12-11 CN CN 201010600836 patent/CN102049033A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 《中国农村医学》 19830430 余贤传 穴位贴敷治疗小儿咳喘 第11页 1-2 , 第2期 2 * |
| 《中国民间特色疗法》 20061231 谭兴贵等 11 消喘膏 湖南科学技术出版社 第417页 2 , 1 * |
| 《中国民间特色疗法》 20061231 谭兴贵等 11 消喘膏，13 咳喘膏 湖南科学技术出版社 第417-418页11 消喘膏项下，13 咳喘膏项下 1-2 , 1 * |
| 《针灸名师临床笔记丛书.肺系病证卷》 20080930 孔立红等 莨菪消喘膏敷贴贝俞穴 中国医药科技出版社 第59页 1-2 , 1 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110702A (en) * | 2013-03-08 | 2013-05-22 | 刘清池 | Navel-warming paste capable of warming spleen and stomach for dispelling cold and preparation method thereof |
| CN103830703A (en) * | 2014-03-07 | 2014-06-04 | 河南中医学院 | Acupoint patch for treating cold pain |
| CN104906207A (en) * | 2015-07-02 | 2015-09-16 | 昆明市中医医院 | External treatment drug for preventing chronic obstructive pulmonary disease from attacking and preparation method of external treatment drug |
| CN104906207B (en) * | 2015-07-02 | 2018-09-14 | 昆明市中医医院 | It is a kind of prevent Chronic Obstructive Pulmonary Disease breaking-out outer control drug and preparation method thereof |
| CN114209804A (en) * | 2021-11-29 | 2022-03-22 | 德阳市中西医结合医院 | Navel patch for treating chronic obstructive pulmonary disease |
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Open date: 20110511 |