CN116616291A - 一种用于内镜消毒的过氧乙酸消毒液及应用 - Google Patents

一种用于内镜消毒的过氧乙酸消毒液及应用 Download PDF

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CN116616291A
CN116616291A CN202310613096.8A CN202310613096A CN116616291A CN 116616291 A CN116616291 A CN 116616291A CN 202310613096 A CN202310613096 A CN 202310613096A CN 116616291 A CN116616291 A CN 116616291A
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peracetic acid
component
endoscope
triazole
disinfectant
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王均胜
刘淑芳
赵怀华
赵可龙
徐胤珂
田友昊
宋存雪
徐玥琳
程明胜
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Shinva Medical Instrument Co Ltd
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Abstract

本发明提供了一种用于内镜消毒的过氧乙酸消毒液，本发明中的消毒剂与常规的消毒剂不同，在充分考虑内镜洗消环境、过氧乙酸特性及人性化使用等因素下，采用过氧乙酸和缓蚀剂搭配的形式，在确保内镜高水平消毒或灭菌合格的前提下，有效缓解过氧乙酸腐蚀性，且使用过程中两者直接混合，无需活化等待，也不需额外添加纯化水，大大提高了医院使用方便性及工作效率。本发明还提供了一种过氧乙酸消毒液在内镜消毒中的应用。

Description

一种用于内镜消毒的过氧乙酸消毒液及应用
技术领域
本发明属于医用消毒技术领域，尤其涉及一种用于内镜消毒的过氧乙酸消毒液及应用。
背景技术
根据国家对于软式内镜清洗消毒的规范，要求所有软式内镜每次使用后均应进行彻底清洗和高水平消毒或灭菌。规范同时指出软式内镜及重复使用的附件、诊疗用品分类处理应遵循的原则。进入人体无菌组织、器官、或接触破损皮肤、破损粘膜的软式内镜及附件应进行灭菌；与完整黏膜接触，而不进入人体无菌组织、器官，也不接触破损皮肤、破损黏膜的软式内镜及附属物品、器具，应进行高水平消毒。
目前用于内镜高水平消毒或灭菌的主要消毒剂为戊二醛、邻苯二甲醛或传统过氧乙酸等，这些消毒剂中有些难以达到灭菌水平，如邻苯二甲醛；有些消毒灭菌时间过长，如戊二醛；有些对内镜存在较大腐蚀或使用不方便，如传统过氧乙酸。目前现有的过氧乙酸消毒剂多采用过氧乙酸稀释后直接使用的方式进行软式内镜高水平消毒或灭菌，这种方式存在腐蚀性大，用户使用麻烦等问题。
发明内容
本发明的目的在于提供一种用于内镜消毒的过氧乙酸消毒液及应用，本发明中的过氧乙酸消毒液能够有效减缓过氧乙酸腐蚀性，并且使用方便，无需活化等待或者额外纯化水，提高了医院使用方便性和工作效率。
本发明提供一种用于内镜消毒的过氧乙酸消毒液，包括组分A和组分B；
组分A包括0.1～35wt％的过氧化氢，0.3～20wt％的过氧乙酸、0.001～0.1wt％的稳定剂和余量的水；
组分B包括0.005～0.1wt％的缓蚀剂、0.001～0.1wt％的表面活性剂、4～10wt％的pH调节剂和余量的水；
所述缓蚀剂为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种。
优选的，所述稳定剂为羟基乙叉二磷酸和/或三聚磷酸钠。
优选的，所述表面活性剂为十二烷基苯磺酸钠。
优选的，所述pH调节剂为磷酸二氢钠和/或磷酸二氢钾。
优选的，组分A和组分B的混合液中，过氧乙酸的质量浓度为0.2～0.4％。
本发明提供如上文所述的用于内镜消毒的过氧乙酸消毒液在内镜消毒中的应用。
优选的，使用时将组分A和组分B按比例混合后直接使用。
本发明提供了一种用于内镜消毒的过氧乙酸消毒液，包括组分A和组分B；组分A包括0.1～35wt％的过氧化氢，0.3～20wt％的过氧乙酸、0.001～0.1wt％的稳定剂和余量的水；组分B包括0.005～0.1wt％的缓蚀剂、0.001～0.1wt％的表面活性剂、4～10wt％的pH调节剂和余量的水；所述缓蚀剂为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种。本发明中的消毒剂与常规的消毒剂不同，在充分考虑内镜洗消环境、过氧乙酸特性及人性化使用等因素下，采用过氧乙酸和缓蚀剂搭配的形式，在确保内镜高水平消毒或灭菌合格的前提下，有效缓解过氧乙酸腐蚀性，且使用过程中两者直接混合，无需活化等待，也不需额外添加纯化水，大大提高了医院使用方便性及工作效率。
具体实施方式
本发明提供了一种用于内镜消毒的过氧乙酸消毒液，包括组分A和组分B；
组分A包括0.1～35wt％的过氧化氢，0.3～20wt％的过氧乙酸、0.001～0.1wt％的稳定剂和余量的水；
组分B包括0.005～0.1wt％的缓蚀剂、0.001～0.1wt％的表面活性剂、4～10wt％的pH调节剂和余量的水；
所述缓蚀剂为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种。
在本发明中，组分A中，过氧化氢的质量分数优选为0.1～35％，更优选为1～30％，如0.1％，0.5％，1％，2％，3％，4％，5％，10％，15％，20％，25％，30％，35％，优选为以上述任意数值为上限或下限的范围值；过氧乙酸的质量分数优选为0.3～20％，更优选为1～15％，如0.3％，0.5％，1％，2％，3％，4％，5％，10％，15％，20％，优选为以上述任意数值为上限或下限的范围值。
所述稳定剂优选为羟基乙叉二磷酸和/或三聚磷酸钠，所述稳定剂的质量分数优选为0.001～0.1％，更优选为0.01～0.08％，如0.001％，0.01％，0.02％，0.03％，0.04％，0.05％，0.06％，0.07％，0.08％，0.09％，0.1％，优选为以上述任意数值为上限或下限的范围值。
在本发明中，所述组分B中，所述缓蚀剂优选为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种；缓蚀剂的质量分数优选为0.005～0.1％，更优选为0.01～0.08％，如0.005％，0.01％，0.02％，0.03％，0.04％，0.05％，0.06％，0.07％，0.08％，0.09％，0.1％，优选为以上述任意数值为上限或下限的范围值。
所述表面活性剂优选为十二烷基苯磺酸钠，所述表面活性剂的质量分数优选为0.001～0.1％，更优选为0.01～0.08％，如0.001％，0.01％，0.02％，0.03％，0.04％，0.05％，0.06％，0.07％，0.08％，0.09％，0.1％，优选为以上述任意数值为上限或下限的范围值。
所述pH调节剂优选为磷酸二氢钠和/或磷酸二氢钾，所述pH调节剂的质量分数优选为4～10％，更优选为5～8％，如4％，5％，6％，7％，8％，9％，10％，优选为以上述任意数值为上限或下限的范围值。
在本发明中，组分A和组分B的混合液中，过氧乙酸的质量浓度优选为0.2～0.4％，更优选为0.3～0.35％。
本发明对所述组分A和组分B的制备方法没有特殊的要求，将相应的成分与水混合即可得到。
本发明还提供了一种上文所述的用于内镜消毒的过氧乙酸消毒液在内镜消毒中的应用。
本发明中的消毒液使用更加方便，直接将组分A和组分B混合后即可使用，无需活化等待，也无需额外添加纯化水，提高了医院使用的方便性和工作效率。
本发明提供了一种用于内镜消毒的过氧乙酸消毒液，包括组分A和组分B；组分A包括0.1～35wt％的过氧化氢，0.3～20wt％的过氧乙酸、0.001～0.1wt％的稳定剂和余量的水；组分B包括0.005～0.1wt％的缓蚀剂、0.001～0.1wt％的表面活性剂、4～10wt％的pH调节剂和余量的水；所述缓蚀剂为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种。本发明中的消毒剂与常规的消毒剂不同，在充分考虑内镜洗消环境、过氧乙酸特性及人性化使用等因素下，采用过氧乙酸和缓蚀剂搭配的形式，在确保内镜高水平消毒或灭菌合格的前提下，有效缓解过氧乙酸腐蚀性，且使用过程中两者直接混合，无需活化等待，也不需额外添加纯化水，大大提高了医院使用方便性及工作效率。
为了进一步说明本发明，以下结合实施例对本发明提供的一种用于内镜消毒的过氧乙酸消毒液及应用进行详细描述，但不能将其理解为对本发明保护范围的限定。
实施例1
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
实施例2
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由1-对甲苯基-1H-1，2，3-三唑-4-甲醇0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
实施例3
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
实施例4
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇0.1wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
实施例5
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇0.05wt％，5-甲基-1H-苯并三唑0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
实施例6
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由1-对甲苯基-1H-1，2，3-三唑-4-甲醇0.05wt％，5-甲基-1H-苯并三唑0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
对比例1
A剂过氧化氢12wt％，过氧乙酸7wt％，羟基乙叉二磷酸0.05wt％，余量为水；
B剂由苯并三氮唑0.05wt％，十二烷基苯磺酸钠0.01wt％，磷酸二氢钠4wt％，余量为水。
A剂与B剂混合后，过氧乙酸浓度为0.3％
使用实施例1～6和对比例1中的消毒液进行金属腐蚀性测试条件
检测环境：温度：20℃，湿度：52％RH；
检验依据：《消毒技术规范》(2002年版)2.2.4
表1实施例和对比例中消毒液的腐蚀速率(mm/a)
实施例1 实施例2 实施例3 实施例4 实施例5 实施例6 对比例1
不锈钢 0.0048 0.0076 0.0093 0.0084 0.0037 0.0044 0.0157
碳钢 0.0789 0.1004 0.0974 0.0896 0.0598 0.0879 1.9872
铝 0.0509 0.0967 0.0567 0.0254 0.0079 0.0096 0.8254
铜 0.1688 0.1979 0.1989 0.1845 0.0988 0.1378 1.2638
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (7)

1.一种用于内镜消毒的过氧乙酸消毒液，包括组分A和组分B；
组分A包括0.1～35wt％的过氧化氢，0.3～20wt％的过氧乙酸、0.001～0.1wt％的稳定剂和余量的水；
组分B包括0.005～0.1wt％的缓蚀剂、0.001～0.1wt％的表面活性剂、4～10wt％的pH调节剂和余量的水；
所述缓蚀剂为2-[1-甲苯-4-磺酰基)-1H-[1，2，3]三唑-4-基]-丙醇，5-甲基-1H-苯并三唑，1-(4-碘苄基)-4-苯氧基甲基-1H-1，2，3-三氮唑，1-(4-基甲基吡啶)-1H-1，2，3-三氮唑-4-甲醇和1-对甲苯基-1H-1，2，3-三唑-4-甲醇中的一种或几种。
2.根据权利要求1所述的用于内镜消毒的过氧乙酸消毒液，其特征在于，所述稳定剂为羟基乙叉二磷酸和/或三聚磷酸钠。
3.根据权利要求1所述的用于内镜消毒的过氧乙酸消毒液，其特征在于，所述表面活性剂为十二烷基苯磺酸钠。
4.根据权利要求1所述的用于内镜消毒的过氧乙酸消毒液，其特征在于，所述pH调节剂为磷酸二氢钠和/或磷酸二氢钾。
5.根据权利要求1所述的用于内镜消毒的过氧乙酸消毒液，其特征在于，组分A和组分B的混合液中，过氧乙酸的质量浓度为0.2～0.4％。
6.如权利要求1～5任意一项所述的用于内镜消毒的过氧乙酸消毒液在内镜消毒中的应用。
7.根据权利要求5所述的应用，其特征在于，使用时将组分A和组分B按比例混合后直接使用。
CN202310613096.8A 2023-05-26 2023-05-26 一种用于内镜消毒的过氧乙酸消毒液及应用 Pending CN116616291A (zh)

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