CN116606226A - Creatine magnesium and preparation method thereof - Google Patents
Creatine magnesium and preparation method thereof Download PDFInfo
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- CN116606226A CN116606226A CN202310608445.7A CN202310608445A CN116606226A CN 116606226 A CN116606226 A CN 116606226A CN 202310608445 A CN202310608445 A CN 202310608445A CN 116606226 A CN116606226 A CN 116606226A
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- magnesium
- creatine
- sarcosinate
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- cyanamide
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- 239000011777 magnesium Substances 0.000 title claims abstract description 59
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 58
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 229960003624 creatine Drugs 0.000 title claims abstract description 27
- 239000006046 creatine Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- BJCXCBUSSZQGPW-UHFFFAOYSA-L magnesium 2-(methylamino)acetate Chemical compound [Mg++].CNCC([O-])=O.CNCC([O-])=O BJCXCBUSSZQGPW-UHFFFAOYSA-L 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 239000013078 crystal Substances 0.000 claims abstract description 9
- 239000008213 purified water Substances 0.000 claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 8
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000012452 mother liquor Substances 0.000 claims abstract description 6
- 238000002425 crystallisation Methods 0.000 claims abstract description 5
- 230000008025 crystallization Effects 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 claims abstract description 4
- 108010077895 Sarcosine Proteins 0.000 claims abstract description 3
- 229940043230 sarcosine Drugs 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 8
- MEJYXFHCRXAUIL-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;hydrate Chemical compound O.NC(=N)N(C)CC(O)=O MEJYXFHCRXAUIL-UHFFFAOYSA-N 0.000 abstract description 6
- 229960004826 creatine monohydrate Drugs 0.000 abstract description 6
- 235000016709 nutrition Nutrition 0.000 abstract description 6
- 230000035764 nutrition Effects 0.000 abstract description 5
- 239000013589 supplement Substances 0.000 abstract description 4
- 238000003786 synthesis reaction Methods 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract description 2
- 230000009977 dual effect Effects 0.000 abstract 1
- 229940091250 magnesium supplement Drugs 0.000 description 47
- 239000011573 trace mineral Substances 0.000 description 6
- 235000013619 trace mineral Nutrition 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229940004916 magnesium glycinate Drugs 0.000 description 2
- AACACXATQSKRQG-UHFFFAOYSA-L magnesium;2-aminoacetate Chemical compound [Mg+2].NCC([O-])=O.NCC([O-])=O AACACXATQSKRQG-UHFFFAOYSA-L 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940069978 calcium supplement Drugs 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000002060 circadian Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 235000014268 sports nutrition Nutrition 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The application belongs to the technical field of chemical synthesis, and relates to creatine magnesium and a preparation method thereof. The creatine magnesium is prepared from sarcosine magnesium and cyanamide; firstly, adding purified water and magnesium sarcosinate in sequence, stirring and heating until the purified water and magnesium sarcosinate are completely dissolved; 2. controlling the reaction temperature at 70-80 ℃ and dropwise adding Shan Qingan; 3. preserving heat for a certain time, cooling to 5-10 ℃ and stirring for crystallization; 4. solid-liquid separation is carried out to obtain a crystal and mother liquor; 5. drying the crystal until the water content is less than 0.5%, and obtaining the creatine magnesium. The creatine magnesium product has the dual functions of creatine monohydrate and magnesium element, and can be used as a nutrition for sports, body building and physical labor strengthening people and can supplement trace magnesium element; the preparation method has the advantages of simple process, safe and reliable process conditions, no generation of three wastes, economy and environmental protection.
Description
Technical Field
The application belongs to the technical field of chemical synthesis, and relates to creatine magnesium and a preparation method thereof.
Background
The trace element magnesium has very small content in human body, but has strong biological effect. The total amount of magnesium element in a normal human body is about 25 g, wherein 60% of the magnesium element exists in bones, 39% of the magnesium element exists in muscles, and the magnesium element in blood only accounts for 1% of the total magnesium element in the human body. The magnesium element is not only unevenly distributed in the body, but also has a circadian variation. The uneven distribution of magnesium in the body, organs and blood is related to its function.
Magnesium is essential trace element for human body, and has effects of preventing diseases and maintaining nutrient balance of human body with zinc, calcium, etc.; zinc can promote protein synthesis and muscle growth, magnesium can support protein synthesis and strengthen muscle strength, and magnesium can improve insulin synthesis and metabolism.
Magnesium is an extremely important trace element involved in the enzymatic catalysis of the main metabolic process in the body. It has effects in balancing calcium absorption and metabolism, preventing calculus caused by calcium deposition, protecting nervous system, and relieving migraine and menstrual syndrome. In view of the sedative effect of magnesium on central nerves, it can improve sleep quality, relieve muscle fatigue, and simultaneously contribute to improving body immunity.
Summarizing, the trace element magnesium not only can activate the activities of various enzymes in the body, but also can regulate the nerve function, maintain the stability of the nucleic acid structure, participate in the synthesis of protein, regulate the body temperature, improve the sleep and regulate the emotion of people.
Magnesium is involved in almost all metabolism of the human body; comprising the following steps: anxiety, heart disease, muscle spasms, asthma, allergies, inattention, etc., all are associated with the deficiency of elemental magnesium. The American nutrition specialist considers that at least 350mg of magnesium element is required to be taken by adults every day, 450mg of pregnant women and women in lactation period are required to be taken by the adults, and 500-600mg of sports people such as athletes, strong physical workers and the like are required to be taken by the adults. The recommended amount of dietary magnesium for Chinese residents is 330mg per day for adults, which is basically the same as that of international nutritional experts. According to the related data of the U.S. market research institutes, the sales increase rate of magnesium has exceeded the increase rate of calcium, becoming one of the ten most commonly used dietary supplements for U.S. consumers.
At present, magnesium glycinate which is popular in the market accounts for a large proportion in the whole magnesium preparation, and no related report exists on the preparation method and application of the product aiming at creatine with double functions of creatine monohydrate and magnesium element.
Disclosure of Invention
The application aims to provide creatine magnesium which has the double functions of creatine monohydrate and magnesium element, can be used as a nutrition product and can also supplement trace magnesium element.
The application also aims to provide a preparation method of the creatine magnesium, which has the advantages of simple process, safe and reliable process conditions, no three wastes, economy and environmental protection.
The technical scheme for solving the technical problems is as follows.
A creatine magnesium, which has a chemical structural formula:
a preparation method of creatine magnesium adopts raw materials of sarcosine magnesium and cyanamide.
Further, the preparation method of the creatine magnesium comprises the following steps:
(1) Adding purified water into a reaction kettle, starting stirring, adding magnesium sarcosinate, stirring and heating until the magnesium sarcosinate is completely dissolved; wherein the mol ratio of the magnesium sarcosinate to the cyanamide is 1:1-1.1; the consumption of the purified water is 1.5 to 2.5 times of the feeding amount of the magnesium sarcosinate;
(2) Controlling the reaction temperature at 70-80 ℃ and dropwise adding Shan Qingan; wherein the dropping time of the cyanamide is 5-7 hours;
(3) After the addition of the cyanamide is finished, firstly preserving heat for a certain time, then cooling to 5-10 ℃ and stirring for crystallization; wherein the heat preservation time is 0.5-1.5 hours, and the stirring crystallization time is 0.3-1 hour;
(4) Solid-liquid separation is carried out to obtain a crystal and mother liquor; wherein, the obtained mother liquor can be returned to the step (1) for recycling;
(5) Drying the crystal until the water content is less than 0.5%, and obtaining the creatine magnesium; wherein the drying temperature is 75-85 ℃.
The chemical reaction equation of the preparation method of the creatine magnesium is as follows.
The creatine magnesium and the preparation method thereof have the beneficial effects that the creatine magnesium product has the double functions of creatine monohydrate and magnesium element, and can supplement trace magnesium element when being used as a nutrition for sports, body building and physical labor strengthening people; the creatine magnesium has the characteristics of good solubility, high absorption and utilization rate and the like, and particularly has more obvious absorption and utilization effects and energy supplementing advantages compared with the magnesium glycinate; the preparation method of the creatine magnesium has simple process, safe and reliable process conditions and no three wastes, and is an economic and environment-friendly preparation method; the creatine magnesium product effectively fills the blank of trace element magnesium supplements at home and abroad, and has wide application prospect.
Detailed Description
Example 1
A creatine magnesium, which has a chemical structural formula:
the molecular formula is as follows: c (C) 8 H 16 N 6 O 4 Mg; the molecular weight is as follows: 284.586.
the physical and chemical properties are as follows: white crystals or crystalline powder, odorless, hygroscopic; is soluble in water, and its aqueous solution is alkaline and is insoluble in alcohol, ether, ethyl acetate and acetone.
The application of the method is as follows: as a downstream product of sports nutrition creatine monohydrate, is mainly used as a functional nutrition enhancer and a supplement of trace element magnesium, is a sports nutritional supplement of a creatine monohydrate upgrade, is a functional food additive expected to exceed a calcium supplement, and has wide application prospect.
Example 2
The preparation method of the creatine magnesium in the embodiment 1 adopts raw materials of sarcosinate magnesium and cyanamide; specifically, the molar ratio of magnesium sarcosinate to cyanamide is 1:1.02. In addition, the magnesium sarcosinate used in the application is magnesium sarcosinate prepared in CN202210904253.6, a preparation method of magnesium sarcosinate chelate.
The preparation method of the creatine magnesium comprises the following steps:
(1) Accurately metering purified water with the dosage of 2 times of magnesium sarcosinate, putting the purified water into a reaction kettle, starting stirring, putting the magnesium sarcosinate with the technological dosage, continuously stirring and heating until the magnesium sarcosinate is completely dissolved;
(2) Controlling the reaction temperature at 70-80 ℃, dropwise adding the process amount of cyanamide, and keeping uniform dropwise adding after the dropwise adding is completed for about 6 hours;
(3) After the addition of the cyanamide is finished, preserving the heat for 1 hour at the temperature of 70-80 ℃, cooling to 5-10 ℃ by cold water, and stirring and crystallizing for 30 minutes at the temperature;
(4) Carrying out solid-liquid separation on the reaction liquid containing the product obtained in the step (3) to obtain a crystal and a mother liquid; the mother liquor can be returned to the step (1) to replace purified water for recycling;
(5) Drying the crystal in the step (4) at 80 ℃ until the moisture is less than 0.5%, and obtaining the creatine magnesium product.
Claims (10)
1. The creatine magnesium is characterized by having a chemical structural formula:
2. a preparation method of creatine magnesium is characterized in that the adopted raw materials are sarcosine magnesium and cyanamide.
3. The method of manufacturing as claimed in claim 2, comprising the steps of:
(1) Adding purified water into a reaction kettle, starting stirring, adding magnesium sarcosinate, stirring and heating until the magnesium sarcosinate is completely dissolved;
(2) Controlling the reaction temperature at 70-80 ℃ and dropwise adding Shan Qingan;
(3) After the addition of the cyanamide is finished, firstly preserving heat for a certain time, then cooling to 5-10 ℃ and stirring for crystallization;
(4) Solid-liquid separation is carried out to obtain a crystal and mother liquor;
(5) Drying the crystal until the water content is less than 0.5%, and obtaining the creatine magnesium.
4. The process according to claim 3, wherein in the step (1), the molar ratio of magnesium sarcosinate to cyanamide is 1:1 to 1.1.
5. The method according to claim 3, wherein the purified water is used in an amount of 1.5 to 2.5 times the amount of magnesium sarcosinate fed in step (1).
6. The process according to claim 3, wherein the dropping time of the cyanamide in the step (2) is 5 to 7 hours.
7. The method according to claim 3, wherein in the step (3), the time for heat preservation is 0.5 to 1.5 hours.
8. The process according to claim 3, wherein in the step (3), the time for stirring crystallization is 0.3 to 1 hour.
9. The process according to claim 3, wherein in the step (5), the drying temperature is 75℃to 85 ℃.
10. The method according to claim 3, wherein the mother liquor obtained in the step (4) is returned to the step (1) for recycling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310608445.7A CN116606226A (en) | 2023-05-27 | 2023-05-27 | Creatine magnesium and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310608445.7A CN116606226A (en) | 2023-05-27 | 2023-05-27 | Creatine magnesium and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116606226A true CN116606226A (en) | 2023-08-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310608445.7A Pending CN116606226A (en) | 2023-05-27 | 2023-05-27 | Creatine magnesium and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116606226A (en) |
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2023
- 2023-05-27 CN CN202310608445.7A patent/CN116606226A/en active Pending
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