CN116583601A - 十足目甲壳类的生长调节方法 - Google Patents
十足目甲壳类的生长调节方法 Download PDFInfo
- Publication number
- CN116583601A CN116583601A CN202180073418.3A CN202180073418A CN116583601A CN 116583601 A CN116583601 A CN 116583601A CN 202180073418 A CN202180073418 A CN 202180073418A CN 116583601 A CN116583601 A CN 116583601A
- Authority
- CN
- China
- Prior art keywords
- growth
- gene
- molting
- related gene
- function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000012010 growth Effects 0.000 title claims abstract description 147
- 238000000034 method Methods 0.000 title claims abstract description 131
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 38
- 241000238424 Crustacea Species 0.000 title abstract description 20
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 368
- 241001465754 Metazoa Species 0.000 claims abstract description 92
- 230000026267 regulation of growth Effects 0.000 claims abstract description 83
- 108091008611 Protein Kinase B Proteins 0.000 claims abstract description 57
- 230000037361 pathway Effects 0.000 claims abstract description 51
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 42
- 238000013519 translation Methods 0.000 claims abstract description 40
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims abstract description 34
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims abstract description 34
- 238000013518 transcription Methods 0.000 claims abstract description 28
- 230000035897 transcription Effects 0.000 claims abstract description 28
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 16
- 230000014509 gene expression Effects 0.000 claims description 65
- 101000795659 Homo sapiens Tuberin Proteins 0.000 claims description 56
- 102100031638 Tuberin Human genes 0.000 claims description 54
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims description 45
- 102100031561 Hamartin Human genes 0.000 claims description 43
- 230000005764 inhibitory process Effects 0.000 claims description 35
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims description 34
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims description 34
- 230000009368 gene silencing by RNA Effects 0.000 claims description 28
- 101001059929 Caenorhabditis elegans Forkhead box protein O Proteins 0.000 claims description 27
- 101100463130 Arabidopsis thaliana PDK gene Proteins 0.000 claims description 24
- 101150063097 ppdK gene Proteins 0.000 claims description 24
- 230000002708 enhancing effect Effects 0.000 claims description 21
- 108091030071 RNAI Proteins 0.000 claims description 20
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 18
- 101100510416 Drosophila melanogaster Kr-h1 gene Proteins 0.000 claims description 16
- 108050008367 Transmembrane emp24 domain-containing protein 7 Proteins 0.000 claims description 16
- 101150020518 RHEB gene Proteins 0.000 claims description 15
- 102000046951 Ras Homolog Enriched in Brain Human genes 0.000 claims description 15
- 108700019578 Ras Homolog Enriched in Brain Proteins 0.000 claims description 15
- 230000033228 biological regulation Effects 0.000 claims description 14
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims description 13
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims description 13
- 102100024908 Ribosomal protein S6 kinase beta-1 Human genes 0.000 claims description 13
- 101710108924 Ribosomal protein S6 kinase beta-1 Proteins 0.000 claims description 13
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 12
- 101000891627 Homo sapiens TBC1 domain family member 7 Proteins 0.000 claims description 12
- 102100040254 TBC1 domain family member 7 Human genes 0.000 claims description 12
- 239000013598 vector Substances 0.000 claims description 12
- 238000010362 genome editing Methods 0.000 claims description 10
- 239000003112 inhibitor Substances 0.000 claims description 9
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims description 8
- 210000000349 chromosome Anatomy 0.000 claims description 7
- 230000000692 anti-sense effect Effects 0.000 claims description 6
- 230000007849 functional defect Effects 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 108700026220 vif Genes Proteins 0.000 claims description 2
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 claims 4
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 claims 4
- 101000928788 Drosophila melanogaster Death-associated inhibitor of apoptosis 2 Proteins 0.000 claims 2
- 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 claims 2
- 101000804865 Homo sapiens E3 ubiquitin-protein ligase XIAP Proteins 0.000 claims 2
- 241000238557 Decapoda Species 0.000 abstract description 40
- 230000001737 promoting effect Effects 0.000 abstract description 18
- 230000006870 function Effects 0.000 description 86
- 108020004414 DNA Proteins 0.000 description 54
- 230000000694 effects Effects 0.000 description 39
- 108010011376 AMP-Activated Protein Kinases Proteins 0.000 description 34
- 102000014156 AMP-Activated Protein Kinases Human genes 0.000 description 32
- 102000004169 proteins and genes Human genes 0.000 description 28
- 241001425786 Procambarus virginalis Species 0.000 description 26
- 101710102814 Molt-inhibiting hormone Proteins 0.000 description 23
- 230000002441 reversible effect Effects 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 15
- 102100028588 Protein ZNRD2 Human genes 0.000 description 14
- 101710190529 Insulin-like peptide Proteins 0.000 description 13
- 108091023037 Aptamer Proteins 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 230000008859 change Effects 0.000 description 8
- 238000007796 conventional method Methods 0.000 description 8
- 230000002596 correlated effect Effects 0.000 description 8
- 235000013601 eggs Nutrition 0.000 description 8
- -1 fatty acid ester Chemical class 0.000 description 8
- 238000003197 gene knockdown Methods 0.000 description 8
- 238000000513 principal component analysis Methods 0.000 description 8
- 238000003753 real-time PCR Methods 0.000 description 8
- 239000000556 agonist Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 238000009313 farming Methods 0.000 description 7
- 230000009036 growth inhibition Effects 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 108020004459 Small interfering RNA Proteins 0.000 description 6
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 239000003623 enhancer Substances 0.000 description 6
- 230000007613 environmental effect Effects 0.000 description 6
- 239000013604 expression vector Substances 0.000 description 6
- 230000019491 signal transduction Effects 0.000 description 6
- 241000238017 Astacoidea Species 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 230000009454 functional inhibition Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000000692 Student's t-test Methods 0.000 description 4
- 230000006866 deterioration Effects 0.000 description 4
- 210000002257 embryonic structure Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 101000690268 Homo sapiens Proline-rich AKT1 substrate 1 Proteins 0.000 description 3
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 description 3
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 description 3
- 102100024091 Proline-rich AKT1 substrate 1 Human genes 0.000 description 3
- 102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 3
- 108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 3
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 description 3
- 238000001772 Wald test Methods 0.000 description 3
- 238000001790 Welch's t-test Methods 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000004520 electroporation Methods 0.000 description 3
- 238000010195 expression analysis Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 230000031586 molting cycle Effects 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000238553 Litopenaeus vannamei Species 0.000 description 2
- 102000038030 PI3Ks Human genes 0.000 description 2
- 108091007960 PI3Ks Proteins 0.000 description 2
- 241000238552 Penaeus monodon Species 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 108091027967 Small hairpin RNA Proteins 0.000 description 2
- 208000026911 Tuberous sclerosis complex Diseases 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000012353 t test Methods 0.000 description 2
- 230000002463 transducing effect Effects 0.000 description 2
- 238000010361 transduction Methods 0.000 description 2
- 230000026683 transduction Effects 0.000 description 2
- WZHKXNSOCOQYQX-FUAFALNISA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 WZHKXNSOCOQYQX-FUAFALNISA-N 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 108091033409 CRISPR Proteins 0.000 description 1
- 241001529572 Chaceon affinis Species 0.000 description 1
- 101150066002 GFP gene Proteins 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 101000827703 Homo sapiens Polyphosphoinositide phosphatase Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 241001124325 Marsupenaeus japonicus Species 0.000 description 1
- 239000012807 PCR reagent Substances 0.000 description 1
- 241000238127 Pagurus Species 0.000 description 1
- 241000241034 Palaemon pugio Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 101150072313 Pdk gene Proteins 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 102100023591 Polyphosphoinositide phosphatase Human genes 0.000 description 1
- 241000238147 Portunidae Species 0.000 description 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 description 1
- 108091027544 Subgenomic mRNA Proteins 0.000 description 1
- 238000010459 TALEN Methods 0.000 description 1
- 108091028113 Trans-activating crRNA Proteins 0.000 description 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000013501 data transformation Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 108010015153 growth hormone releasing hexapeptide Proteins 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/60—New or modified breeds of invertebrates
- A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
- A01K67/65—Genetically modified arthropods
- A01K67/67—Genetically modified crustaceans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020-179947 | 2020-10-27 | ||
| JP2020179947 | 2020-10-27 | ||
| PCT/JP2021/039717 WO2022092170A1 (ja) | 2020-10-27 | 2021-10-27 | 十脚目甲殻類の成長調節方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116583601A true CN116583601A (zh) | 2023-08-11 |
Family
ID=81382658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180073418.3A Pending CN116583601A (zh) | 2020-10-27 | 2021-10-27 | 十足目甲壳类的生长调节方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230397582A1 (https=) |
| JP (1) | JP7636756B2 (https=) |
| CN (1) | CN116583601A (https=) |
| WO (1) | WO2022092170A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119177296A (zh) * | 2024-10-31 | 2024-12-24 | 广西壮族自治区水产科学研究院(广西壮族自治区渔业病害防治环境监测和质量检验中心、广西壮族自治区水生野生动物救护中心) | 一种南美白对虾Raptor基因SNP分子标记及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5754681B2 (ja) | 2008-05-14 | 2015-07-29 | 国立研究開発法人農業生物資源研究所 | 幼若ホルモン応答エレメント |
| JP6789513B2 (ja) | 2016-11-01 | 2020-11-25 | 国立研究開発法人国際農林水産業研究センター | 有用エビ類の卵成熟抑制を解除する方法 |
-
2021
- 2021-10-27 JP JP2022559212A patent/JP7636756B2/ja active Active
- 2021-10-27 US US18/033,987 patent/US20230397582A1/en active Pending
- 2021-10-27 WO PCT/JP2021/039717 patent/WO2022092170A1/ja not_active Ceased
- 2021-10-27 CN CN202180073418.3A patent/CN116583601A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119177296A (zh) * | 2024-10-31 | 2024-12-24 | 广西壮族自治区水产科学研究院(广西壮族自治区渔业病害防治环境监测和质量检验中心、广西壮族自治区水生野生动物救护中心) | 一种南美白对虾Raptor基因SNP分子标记及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2022092170A1 (https=) | 2022-05-05 |
| JP7636756B2 (ja) | 2025-02-27 |
| WO2022092170A1 (ja) | 2022-05-05 |
| US20230397582A1 (en) | 2023-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huo et al. | Comparison of muscle fiber characteristics and glycolytic potential between slow-and fast-growing broilers | |
| Li et al. | Plant MIR156 regulates intestinal growth in mammals by targeting the Wnt/β-catenin pathway | |
| Lee et al. | Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish | |
| Panserat et al. | New insights on intermediary metabolism for a better understanding of nutrition in teleosts | |
| Shibata et al. | Knocking out histone methyltransferase PRMT1 leads to stalled tadpole development and lethality in Xenopus tropicalis | |
| Shen et al. | MyoG-enhanced circGPD2 regulates chicken skeletal muscle development by targeting miR-203a | |
| Huang et al. | mTOR signaling pathway regulates embryonic development and rapid growth of triploid crucian carp | |
| Bian et al. | Transcriptome analysis of gene expression patterns during embryonic development in golden cuttlefish (Sepia esculenta) | |
| CN118252124B (zh) | 草鱼pi4kb为靶标分子在制备抗出血病和/或速生草鱼中的应用 | |
| Yalcin et al. | Effect of egg storage duration and brooding temperatures on chick growth, intestine morphology and nutrient transporters | |
| Huang et al. | Identification and expression analysis of cobia (Rachycentron canadum) liver-related miRNAs under hypoxia stress | |
| CN102077797A (zh) | 一种通过罗非鱼控制对虾病害的生物防控方法 | |
| Zhu et al. | Fatter or stronger: resource allocation strategy and the underlying metabolic mechanisms in amphibian tadpoles | |
| CN116583601A (zh) | 十足目甲壳类的生长调节方法 | |
| Zhong et al. | Low expression of miR-19a-5p is associated with high mRNA expression of diacylglycerol O-acyltransferase 2 (DGAT2) in hybrid tilapia | |
| Tao et al. | Silencing the fatty acid elongase gene elovl6 induces reprogramming of nutrient metabolism in male Oreochromis niloticus | |
| CN102041257B (zh) | 抑制鸡肌肉生成抑制素基因表达的siRNA及其应用 | |
| Cao et al. | Branched‐Chain Amino Acids Target miR‐203a/fosb Axis to Promote Skeletal Muscle Growth in Common Carp (Cyprinus carpio) | |
| CN112375759B (zh) | 一种与鸡肝脏脂质沉积相关的miRNA及其应用 | |
| Wang et al. | Transcriptome analysis of testis in response to silencing of Piwi2 sheds light on spermatogenesis in the mud crab Scylla paramamosain | |
| JP5522435B2 (ja) | Ｍｘｄ３遺伝子の発現阻害による肥満の抑制 | |
| CN104232643B (zh) | RNAi干扰片段、干扰载体、制备方法及其应用 | |
| Wu et al. | The analysis of growth performance and expression of growth-related genes in natural gynogenic blunt snout bream muscle derived from the blunt snout bream (Megalobrama amblycephala,♀)× Chinese perch (Siniperca chuatsi,♂) | |
| CN110506676A (zh) | Elovl1基因及其应用 | |
| CN115992216A (zh) | 几种Eif1a基因及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |