CN116574132A - 用作抗生素的Korormicin衍生物 - Google Patents
用作抗生素的Korormicin衍生物 Download PDFInfo
- Publication number
- CN116574132A CN116574132A CN202310483500.4A CN202310483500A CN116574132A CN 116574132 A CN116574132 A CN 116574132A CN 202310483500 A CN202310483500 A CN 202310483500A CN 116574132 A CN116574132 A CN 116574132A
- Authority
- CN
- China
- Prior art keywords
- compound
- peg
- carbon atoms
- independently selected
- korormicin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151902P | 2015-04-23 | 2015-04-23 | |
| US62/151,902 | 2015-04-23 | ||
| CN201680033925.3A CN107708689A (zh) | 2015-04-23 | 2016-04-22 | 用作抗生素的Korormicin衍生物 |
| PCT/CA2016/050470 WO2016168938A1 (en) | 2015-04-23 | 2016-04-22 | Derivatives of korormicin useful as antibiotics |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680033925.3A Division CN107708689A (zh) | 2015-04-23 | 2016-04-22 | 用作抗生素的Korormicin衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116574132A true CN116574132A (zh) | 2023-08-11 |
Family
ID=57142747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310483500.4A Pending CN116574132A (zh) | 2015-04-23 | 2016-04-22 | 用作抗生素的Korormicin衍生物 |
| CN201680033925.3A Pending CN107708689A (zh) | 2015-04-23 | 2016-04-22 | 用作抗生素的Korormicin衍生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680033925.3A Pending CN107708689A (zh) | 2015-04-23 | 2016-04-22 | 用作抗生素的Korormicin衍生物 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10166213B2 (https=) |
| EP (1) | EP3285762A4 (https=) |
| JP (3) | JP6842089B2 (https=) |
| CN (2) | CN116574132A (https=) |
| AU (4) | AU2016253429B2 (https=) |
| CA (1) | CA2983460A1 (https=) |
| IL (2) | IL255182B2 (https=) |
| WO (1) | WO2016168938A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116574132A (zh) * | 2015-04-23 | 2023-08-11 | 维奥提卡生命科学股份有限公司 | 用作抗生素的Korormicin衍生物 |
| CN116617231B (zh) * | 2023-06-12 | 2024-11-15 | 沈阳药科大学 | 2-氨基萘嵌间二氮杂苯氢溴化物增强对革兰氏阴性菌杀菌作用的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2315489A (en) * | 1996-07-17 | 1998-02-04 | Merck & Co Inc | Antifungal agent |
| JP3905604B2 (ja) | 1997-03-04 | 2007-04-18 | 株式会社海洋バイオテクノロジー研究所 | 新規化学物質コロールミシン |
| JP2000281670A (ja) | 1999-03-26 | 2000-10-10 | Marine Biotechnol Inst Co Ltd | 新規コロールミシン合成中間体及び製造法 |
| JP2000336088A (ja) * | 1999-05-27 | 2000-12-05 | Marine Biotechnol Inst Co Ltd | 新規化学物質Ｆ４２０ｍ類縁体 |
| JP2001010908A (ja) * | 1999-06-28 | 2001-01-16 | Marine Biotechnol Inst Co Ltd | 防汚剤 |
| JP2003061645A (ja) | 2001-08-23 | 2003-03-04 | Marine Biotechnol Inst Co Ltd | 海洋細菌の選択培地 |
| EP2136800A4 (en) * | 2007-03-19 | 2011-10-05 | Wisconsin Alumni Res Found | MODULATION OF BACTERIAL QUORUM DETECTION WITH SYNTHETIC LIGANDS |
| EP2448930B1 (en) * | 2009-07-03 | 2017-02-15 | The National Institute for Biotechnology in the Negev Ltd. | N-((S)-2-Oxo-tetrahydro-furan-3-yl)-amide derivatives as inhibitors of the bacterial quorum sensing for treating plant or animal diseases and for preventing the formation of biofilms on medical devices |
| CN116574132A (zh) * | 2015-04-23 | 2023-08-11 | 维奥提卡生命科学股份有限公司 | 用作抗生素的Korormicin衍生物 |
-
2016
- 2016-04-22 CN CN202310483500.4A patent/CN116574132A/zh active Pending
- 2016-04-22 AU AU2016253429A patent/AU2016253429B2/en not_active Ceased
- 2016-04-22 CA CA2983460A patent/CA2983460A1/en active Pending
- 2016-04-22 WO PCT/CA2016/050470 patent/WO2016168938A1/en not_active Ceased
- 2016-04-22 IL IL255182A patent/IL255182B2/en unknown
- 2016-04-22 US US15/500,006 patent/US10166213B2/en active Active
- 2016-04-22 EP EP16782435.8A patent/EP3285762A4/en not_active Ceased
- 2016-04-22 JP JP2017555587A patent/JP6842089B2/ja active Active
- 2016-04-22 CN CN201680033925.3A patent/CN107708689A/zh active Pending
- 2016-04-22 IL IL310102A patent/IL310102A/en unknown
-
2018
- 2018-11-15 US US16/192,117 patent/US10744111B2/en active Active
-
2019
- 2019-04-02 AU AU2019202254A patent/AU2019202254B2/en not_active Ceased
-
2020
- 2020-07-15 US US16/930,178 patent/US11324716B2/en active Active
- 2020-11-11 AU AU2020267205A patent/AU2020267205B2/en not_active Ceased
-
2021
- 2021-02-03 JP JP2021015712A patent/JP7121225B2/ja active Active
-
2022
- 2022-03-02 JP JP2022032136A patent/JP2022122857A/ja active Pending
- 2022-04-27 US US17/660,886 patent/US12029716B2/en active Active
- 2022-07-08 AU AU2022204906A patent/AU2022204906B2/en not_active Ceased
-
2024
- 2024-07-08 US US18/766,386 patent/US20240358670A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019202254A1 (en) | 2019-05-02 |
| JP7121225B2 (ja) | 2022-08-18 |
| US20240358670A1 (en) | 2024-10-31 |
| JP2022122857A (ja) | 2022-08-23 |
| JP2018513194A (ja) | 2018-05-24 |
| AU2022204906A1 (en) | 2022-07-28 |
| AU2020267205B2 (en) | 2022-04-14 |
| EP3285762A1 (en) | 2018-02-28 |
| IL310102A (en) | 2024-03-01 |
| IL255182B1 (en) | 2024-02-01 |
| CN107708689A (zh) | 2018-02-16 |
| CA2983460A1 (en) | 2016-10-27 |
| AU2020267205A1 (en) | 2020-12-10 |
| JP2021073278A (ja) | 2021-05-13 |
| US20180064680A1 (en) | 2018-03-08 |
| AU2016253429B2 (en) | 2019-01-03 |
| AU2022204906B2 (en) | 2024-03-28 |
| EP3285762A4 (en) | 2019-02-06 |
| AU2016253429A1 (en) | 2017-12-07 |
| US10744111B2 (en) | 2020-08-18 |
| US12029716B2 (en) | 2024-07-09 |
| IL255182A0 (en) | 2017-12-31 |
| US10166213B2 (en) | 2019-01-01 |
| US20220257555A1 (en) | 2022-08-18 |
| JP6842089B2 (ja) | 2021-03-17 |
| IL255182B2 (en) | 2024-06-01 |
| US20200345682A1 (en) | 2020-11-05 |
| AU2019202254B2 (en) | 2020-08-13 |
| US20190083450A1 (en) | 2019-03-21 |
| US11324716B2 (en) | 2022-05-10 |
| WO2016168938A1 (en) | 2016-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Denis et al. | Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease | |
| Oliveira et al. | Menthol-based deep eutectic systems as antimicrobial and anti-inflammatory agents for wound healing | |
| Li et al. | Lactobacillus rhamnosus GR-1 prevents Escherichia coli-induced apoptosis through PINK1/Parkin-mediated mitophagy in bovine mastitis | |
| US20240358670A1 (en) | Derivatives of korormicin useful as antibiotics | |
| US20150273025A1 (en) | Apyrase treatments | |
| JP2013523111A (ja) | 転写因子デコイ | |
| Liu et al. | Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo | |
| Pandey et al. | Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-α independent pathway in mouse peritoneal macrophages in vitro | |
| AU2013237576A1 (en) | Use of amphoteric surfactants for the prevention and treatment of pathogenic vaginal biofilms in vaginal infections | |
| Wang et al. | Proguanil and chlorhexidine augment the antibacterial activities of clarithromycin and rifampicin against Acinetobacter baumannii | |
| TW202328169A (zh) | 治療細菌性陰道炎的方法和組合物 | |
| WO2015181084A1 (en) | Use of a nanoemulsion of cinnamaldehyde and/or a metabolite thereof, possibly in association with eugenol and/or carvacrol, to prevent resistance to antibiotics | |
| Pointon | Copper homeostasis and Salmonella pathogenicity: Interplay with resistance to nitrosative stress | |
| Palma et al. | Anti-virulence activity and immunomodulation of Oreoch-1 against enteroinvasive Escherichia coli infection | |
| Weawsiangsang et al. | Investigating antibacterial mechanisms of hydroquinine against Pseudomonas aeruginosa and its application as preventive contact lens solution | |
| WO2024229525A1 (en) | Dysregulation of planktonic bacterial metabolism | |
| Dibrov | Searching for New Antimicrobial Targets: Na+ Cycle in Energetics of Bacterial Pathogens |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |