CN116570636A - 一种解热镇痛的贴膏剂及其制备方法 - Google Patents
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Abstract
本发明公开了一种解热镇痛的贴膏剂及其制备方法，按重量份计，包括以下原料：川芎120‑160份、透骨草120‑160份、热熔胶粘剂600‑800份、薄荷脑40‑50份、桉油20‑30份、氧化锌1份。本发明的解热镇痛的贴膏剂具有活血行气，祛风除湿，通脉止痛保健功效，亦可用于因外感风邪所致发热、咽喉肿痛、头痛等不适，产品功能和使用对象明确。本发明为外用贴膏剂，免于口服用药引起的肝脏损伤，依赖性等副作用。
Description
技术领域
本发明属于中药技术领域，具体来说涉及一种解热镇痛的贴膏剂，同时还涉及其制备方法。
背景技术
疼痛分为急性疼痛和慢性疼痛，急性疼痛多具有突发性，需要及时由医疗人员予以对症治疗。而说到慢性疼痛，由于其致病原因多样，因此在日常生活中尤为常见，常给疼痛患者带来持续性的困扰，不易携带，储存，加之西药止痛类药物若作为日常止痛手段长期服用，有会给患者带来肝肾损伤、依赖性等多种副作用，使患者产生一定的顾虑。
发明内容
本发明的目的在于提供一种疗效好、无毒副作用、制备方法简单的解热镇痛的贴膏剂。
本发明的另一目的在于提供该解热镇痛的贴膏剂的制备方法。
本声明的一种解热镇痛的贴膏剂，按重量份计，包括以下原料：
川芎120-160份、透骨草120-160份、热熔胶粘剂600-800份、薄荷脑40-50份、桉油20-30份、氧化锌1份。
上述的一种解热镇痛的贴膏剂，包括下述重量份的原料：
川芎140份、透骨草140份、热熔胶粘剂700份、薄荷脑45份、桉油25份、氧化锌1份。
上述的解热镇痛的贴膏剂的制备方法，包括以下步骤：
(1)药材提取：取药材川芎120-160份、透骨草120-160份、70％乙醇回流提取两次，第一次6倍量乙醇，回流提取1.5h，第二次4倍量乙醇，回流提取1h，滤过，滤液80℃旋转蒸发浓缩至相对密度为1.15-1.25，得浓缩清膏备用。
(2)热熔胶粘剂熔融：取热熔胶粘剂600-800份，加热熔融保温；
(3)将浓缩清膏1份，薄荷脑40-50份、冰片40-50份、桉油20-30份，氧化锌1份，加入加热熔融的热熔胶中，搅拌均匀，涂布，成型，即得。
本发明与现有技术相比，具有明显的有益效果，从以上技术方案可知：本发明依据中医外治用药原理，遵循中医祛邪通络以止痛的基本原则组方，川芎、透骨香共为方中君药，川芎为治疗血瘀气滞所致疼痛要药，透骨香可对疼痛病因风湿之邪发挥通痹止痛作用，臣以薄荷脑，辅助君药提高“通则不痛”的功效，冰片为佐使之药，取其辛香走窜力强的药性特点，外用透达开窍引药透达肌肤而起效，全方诸药相伍，针对引致疼痛的风寒湿邪、气滞血瘀等病因，共奏活血行气，祛风除湿，通脉止痛保健功效，亦可用于因外感风邪所致发热、咽喉肿痛、头痛等不适，产品功能和使用对象明确。本发明为外用贴膏剂，免于口服用药引起的肝脏损伤，依赖性等副作用。临床共30例使用，总有效率为93.3％。
具体实施方式
以下通过试验例来进一步阐述本发明所述药物的有益效果。
试验例：本发明药物的临床观察
1、临床资料：
治疗病例30例，其中：年龄30-68周岁，男18例，女12例。
2、诊断标准：
《中医病症诊断疗效标准》。
3、治疗方法：
取本发明实施例所得药物，清洁肌肤后，撕开包装贴于不适处，四周按压平整，1贴/天，连续7天使用为1疗程。
注：治疗期间均停用其它治疗药物。
4、疗效判定标准
显效：症状消失；
有效：症状明显缓解；
无效：症状无明显改善。
5、治疗结果：
30例患者使用本发明药物，显效6例，有效22例，无效2例，总有效率93.3％。
通过以下实施例来阐明本药物的制备方法。
实施例1
一种解热镇痛的贴膏剂的制备方法，包括以下步骤：
(1)药材提取：取药材川芎120g、透骨草160g、70％乙醇回流提取两次，第一次6倍量乙醇，回流提取1.5h，第二次4倍量乙醇，回流提取1h，滤过，滤液80℃旋转蒸发浓缩至相对密度为1.15-1.25，得浓缩清膏备用。
(2)热熔胶粘剂熔融：取热熔胶粘剂600g，加热熔融保温；
(3)将浓缩清膏1g，薄荷脑50g、冰片40g、桉油30g，氧化锌1g，加入加热熔融的热熔胶中，搅拌均匀，涂布，成型，即得。
实施例2
一种解热镇痛的贴膏剂的制备方法，包括以下步骤：
(1)药材提取：取药材川芎140g、透骨草140g、70％乙醇回流提取两次，第一次6倍量乙醇，回流提取1.5h，第二次4倍量乙醇，回流提取1h，滤过，滤液80℃旋转蒸发浓缩至相对密度为1.15-1.25，得浓缩清膏备用。
(2)热熔胶粘剂熔融：取热熔胶粘剂700g，加热熔融保温；
(3)将浓缩清膏1g，薄荷脑45g、冰片45g、桉油25g，氧化锌1g，加入加热熔融的热熔胶中，搅拌均匀，涂布，成型，即得。
实施例3
一种解热镇痛的贴膏剂的制备方法，包括以下步骤：
(1)药材提取：取药材川芎160g、透骨草120g、70％乙醇回流提取两次，第一次6倍量乙醇，回流提取1.5h，第二次4倍量乙醇，回流提取1h，滤过，滤液80℃旋转蒸发浓缩至相对密度为1.15-1.25，得浓缩清膏备用。
(2)热熔胶粘剂熔融：取热熔胶粘剂800g，加热熔融保温；
(3)将浓缩清膏1g，薄荷脑40g、冰片50g、桉油20g，氧化锌1g，加入加热熔融的热熔胶中，搅拌均匀，涂布，成型，即得。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，任何未脱离本发明技术方案内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰，均仍属于本发明技术方案的范围内。
Claims (3)
1.一种解热镇痛的贴膏剂，按重量份计，包括以下原料：
川芎120-160份、透骨草120-160份、热熔胶粘剂600-800份、薄荷脑40-50份、桉油20-30份、氧化锌1份。
2.如权利要求1所述的一种解热镇痛的贴膏剂，包括下述重量份的原料：
川芎140份、透骨草140份、热熔胶粘剂700份、薄荷脑45份、桉油25份、氧化锌1份。
3.如权利要求1所述的一种解热镇痛的贴膏剂的制备方法，包括以下步骤：
(1)药材提取：取药材川芎120-160份、透骨草120-160份、70％乙醇回流提取两次，第一次6倍量乙醇，回流提取1.5h，第二次4倍量乙醇，回流提取1h，滤过，滤液80℃旋转蒸发浓缩至相对密度为1.15-1.25，得浓缩清膏备用。
(2)热熔胶粘剂熔融：取热熔胶粘剂600-800份，加热熔融保温；
(3)将浓缩清膏1份，薄荷脑40-50份、冰片40-50份、桉油20-30份，氧化锌1份，加入加热熔融的热熔胶中，搅拌均匀，涂布，成型，即得。
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