CN116500288A - Full-automatic miniature sample transmission detecting system - Google Patents

Abstract

The invention belongs to the technical field of sample detection, and particularly relates to a full-automatic miniature sample transmission detection system, which comprises the following components: the device comprises a base, a support frame body fixedly arranged at the top of the base, a tray rotatably arranged at the outer side of the top of the support frame body, a plurality of sample grooves which are formed in the periphery of the top of the tray and are used for fixing samples, a sample feeding mechanism which is arranged at the side of the tray and is used for pushing single samples into one of the sample grooves, a sample discharging mechanism which is connected with the sample feeding mechanism and is used for pushing detected samples out of the sample grooves, a driving mechanism which is connected with the sample feeding mechanism and can drive the sample feeding mechanism and the sample discharging mechanism to synchronously move, and a detection mechanism which is arranged at the side of the tray and is used for aligning the stationary sample grooves to carry out optical detection and analysis of the samples, wherein the detection mechanism at the side of the tray can be aligned with the sample grooves after the tray is stationary; the sample feeding mechanism and the sample discharging mechanism can feed or push a single sample into or out of the sample tank.

Description

Full-automatic miniature sample transmission detecting system

Technical Field

The invention belongs to the technical field of sample detection, and particularly relates to a full-automatic miniature sample transmission detection system.

Background

Chemical, electrochemical and optical biosensor systems are currently the most commonly used sample analysis platforms in laboratory environments, and these systems rely on the detection of biomolecules (e.g., proteins or enzymes) to provide information about the sample being analyzed; however, the use of these platforms typically requires trained professionals to perform the operations, with expertise to manually prepare, load and analyze the sample, which is time consuming and prone to error, and in addition, in the laboratory, if large transport detection equipment is employed, expensive issues are faced.

Therefore, in some sample detection, manual detection is usually adopted, but the traditional manual detection is time-consuming and labor-consuming, and large errors are easy to be introduced while the detection efficiency is low; in the actual experimental operation process, the requirement of sample batch detection exists, so that the research of a miniature sample transmission detection system capable of fully automatically performing biological optical sensing is necessary.

Disclosure of Invention

The invention aims to provide a full-automatic miniature sample transmission detection system which can be used for carrying out automatic transmission detection analysis on samples, improving detection efficiency, reducing tedious operations of staff and meeting the requirement of batch detection.

The invention is realized in such a way that a fully automatic miniature sample transmission detection system comprises: the device comprises a base, a support frame body fixedly arranged at the top of the base, a tray rotatably arranged at the outer side of the top of the support frame body, a plurality of sample grooves which are formed in the periphery of the top of the tray and are used for fixing samples, a sample feeding mechanism which is arranged at the side of the tray and is used for pushing single samples into one of the sample grooves, a sample discharging mechanism which is connected with the sample feeding mechanism and is used for pushing the detected samples out of the sample grooves, a driving mechanism which is connected with the sample feeding mechanism and can drive the sample feeding mechanism and the sample discharging mechanism to synchronously move, and a detection mechanism which is arranged at the side of the tray and is used for aligning the stationary sample grooves to carry out optical testing of the samples.

According to the full-automatic miniature sample transmission detection system, the supporting frame body is utilized to rotatably mount the supporting tray, and samples are fixed through the plurality of sample grooves formed in the top of the supporting tray, so that the samples positioned in the sample grooves can rotate along with the supporting tray; the detection mechanism positioned beside the bearing tray can be aligned to the sample groove after the bearing tray is static, and the optical detection analysis is carried out on the sample in the sample groove; the sample feeding mechanism and the sample discharging mechanism can feed or push a single sample into or out of the sample groove; because actuating mechanism links to each other simultaneously with sampling mechanism and play prototype, consequently can drive sampling mechanism and play prototype simultaneous movement in order to realize the business turn over sample in the same time of different position sample grooves, and actuating mechanism still can drive the fixed angle rotation of support tray after accomplishing business turn over appearance action and realize the position switching in different sample grooves, and carry out the detection of different sample inslot samples through detection mechanism, consequently realized the automatic transmission of support tray sample, with detection mechanism cooperation can realize the automatic transmission detection analysis of sample, the loaded down with trivial details operation of staff has also been alleviateed when promoting detection efficiency, can satisfy the demand of batch detection.

Preferably, the system further comprises a housing having a hollow interior, the base is fixed to an inner bottom surface of the housing, the top surfaces of the supporting frame and the tray are both beyond the top surface of the housing, and the sample feeding mechanism comprises: the sample injection device comprises a shell, a sample injection guide piece, a sample injection notch and a sample injection assembly, wherein the sample injection guide piece is fixedly arranged on the top surface of the shell and is internally provided with an inclined channel for accommodating a sample, the sample injection notch is formed in the lower end of the sample injection guide piece and can be opposite to the sample groove, and the sample injection assembly is opposite to the sample injection notch and is used for intermittently pushing the sample in the inclined channel into the sample groove.

Preferably, the sample injection assembly includes: the sample injection device comprises a sample injection limiting piece fixedly arranged on the outer side of the sample injection notch, a sample injection push rod connected with the sample injection limiting piece in a sliding mode, and a sample injection unit connected with the sample injection push rod and used for driving the sample injection push rod to reciprocate along the direction perpendicular to the sample injection notch so as to realize intermittent sample injection.

Preferably, the sample injection unit includes: the rotary sampling rotary table comprises a sampling rotary shaft, a sampling rotary table, a sampling cylinder and a sleeve piece, wherein the sampling rotary shaft is rotationally connected to the top of the base, the sampling rotary table is fixedly arranged at the top end of the sampling rotary shaft, the lower bottom surface of the sampling rotary table exceeds the upper top surface of the shell, the sampling cylinder is fixedly arranged at the eccentric position of the top of the sampling rotary table, and the sleeve piece is connected with one end, far away from the sampling notch, of the sampling push rod and is sleeved on the outer side of the sampling cylinder.

Preferably, the support frame body includes: the lower column body, the middle column body and the upper column body which are sequentially and fixedly connected and are hollow are arranged in the lower column body and the upper column body, the lower column body is fixedly installed at the top of the base, the outer diameter of the middle column body is smaller than that of the lower column body and that of the upper column body, the lower bottom surface of the upper column body exceeds the upper top surface of the shell, the support disc is rotationally sleeved on the outer sides of the upper column body and the middle column body, and a through hole for accommodating the sample discharging mechanism is formed in the upper column body in a penetrating mode.

Preferably, the sampling mechanism includes: the rotation install in the base top just is located the internal appearance pivot of going out of support, set firmly in go out appearance pivot upper end and hold and establish go out appearance carousel, set firmly in go out appearance cylinder, one end of appearance carousel top surface eccentric position department go out appearance cylinder rotate connect in go out first appearance bull stick of appearance cylinder, rotate connect in first go out second appearance bull stick of appearance cylinder one end keep away from go out appearance locating part, set firmly in last cylinder top surface and with second appearance bull stick sliding connection's appearance locating part and set firmly in the play appearance guide of casing top surface, go out appearance guide be located the bearing dish outside and inside seted up with the relative play appearance passageway of second appearance bull stick, the opening has been seted up to one side of lower cylinder, go out appearance pivot through pass open-ended band pulley group with advance appearance pivot links to each other in order to realize synchronous rotation.

Preferably, the support tray comprises: the sample tank is arranged at the periphery of the top of the tray body.

Preferably, the sample grooves are formed in an annular array at the top of the tray body and extend inwards from the outer wall of the tray body along the radial direction for a certain distance, the sample grooves are uniformly distributed along the circumferential direction of the tray body, and elastic pieces for fixing samples are mounted on the inner walls of the two sides of each sample groove.

Preferably, the driving mechanism includes: the device comprises a base, a driving motor, a driving shaft, a sample injection intermittent gear, a rotary disc intermittent gear, a sample injection rotating shaft, a rotary disc gear and a rotary disc gear, wherein the driving motor is fixedly arranged inside the base, the driving shaft is connected with the output end of the driving motor, the sample injection intermittent gear and the rotary disc intermittent gear are sequentially and fixedly sleeved on the driving shaft along the axial direction, the sample injection rotating shaft is fixedly sleeved on the sample injection intermittent gear meshed with the sample injection intermittent gear, the rotary disc gear is fixedly sleeved on the outer side of the disc body and meshed with the rotary disc intermittent gear, the sample injection intermittent gear and the rotary disc intermittent gear are incomplete gears and are distributed in dislocation of gear teeth of the incomplete gears, and a bearing which is rotatably sleeved on the middle cylinder body and is propped against the top surface of the lower cylinder is fixedly connected with the rotary disc gear.

Preferably, the detection mechanism includes: the two supporting pieces are respectively arranged at the top of the supporting frame body and the top surface of the machine shell and are positioned at two sides of the sample groove, each supporting piece is provided with an optical fiber port, one optical fiber port is connected with a light source through an optical fiber, the other optical fiber port is connected with an optical analysis instrument through an optical fiber, and the sample groove is positioned between the two optical fiber ports and can be aligned with connecting lines of the two optical fiber ports so as to collect sample information.

Compared with the prior art, the invention has the beneficial effects that:

1. the detection mechanism positioned beside the bearing tray can be aligned to the sample groove after the bearing tray is static, and the optical detection analysis is carried out on the sample in the sample groove; the sample feeding mechanism and the sample discharging mechanism can feed or push a single sample into or out of the sample groove; the driving mechanism is connected with the sample feeding mechanism and the sample discharging mechanism simultaneously, so that the sample feeding mechanism and the sample discharging mechanism can be driven to synchronously move to realize simultaneous sample feeding and discharging of sample grooves at different positions, the driving mechanism can also drive the tray to rotate at a fixed angle to realize position switching of the different sample grooves after sample feeding and discharging actions are completed, and the detection mechanism is used for detecting samples in the different sample grooves, so that automatic transmission of the samples on the tray is realized, automatic transmission detection analysis of the samples can be realized by matching the detection mechanism, complicated operation of staff is reduced while the detection efficiency is improved, and the requirement of batch detection can be met;

2. the device only adopts one driving motor, and drives other mechanisms to move together in a coordinated manner by utilizing the transmission of the gears and the belt wheels, so that high automation is realized, and the tedious operation of researchers in the process of detecting samples is reduced;

3. the device can also realize the requirement of detecting a plurality of samples at the same time by increasing the relation between the optical fiber port and the gear teeth number and the transmission ratio, thereby achieving the requirement of high flux.

Drawings

FIG. 1 is a perspective view of a fully automatic miniature sample transmission detection system provided by the invention;

FIG. 2 is a top view of a fully automated micro sample transfer inspection system according to the present invention;

FIG. 3 is a perspective view of the full-automatic miniature sample transmission detection system provided by the invention with the casing removed;

FIG. 4 is a front elevational view of FIG. 3;

FIG. 5 is a perspective view of a support frame and sample injection assembly of a fully automatic miniature sample transmission detection system according to the present invention;

FIG. 6 is an enlarged view of a portion of FIG. 1 at A;

FIG. 7 is a top view of the connection between the sample injection intermittent gear and the sample injection gear of the full-automatic miniature sample transmission detection system;

fig. 8 is a top view of the connection between the turntable intermittent gear and the turntable gear of the full-automatic miniature sample transmission detection system.

In the accompanying drawings: 1 base, 2 support frame, 21 lower column, 22 middle column, 23 upper column, 3 bearing tray, 31 guide column, 32 disk, 33 elastic piece, 4 sample introduction mechanism, 41 sample introduction guide piece, 42 sample introduction notch, 43 sample introduction assembly, 431 sample introduction limiting piece, 432 sample introduction push rod, 433 sample introduction unit, 4331 sample introduction rotating shaft, 4332 sample introduction rotating disc, 4333 sample introduction cylinder, 4334 sleeve piece, 5 sample introduction mechanism, 51 sample introduction rotating shaft, 52 sample introduction rotating disc, 53 sample introduction cylinder, 54 first sample introduction rotating rod, 55 second sample introduction rotating rod, 56 sample introduction limiting piece, 57 sample introduction guide piece, 6 driving mechanism, 61 bearing, 62 driving shaft, 63 sample introduction intermittent gear, 64 rotating disc intermittent gear, 65 sample introduction gear, 66 rotating disc gear, 7 detection mechanism, 71 support piece, 8 sample introduction groove and 9 shell.

Detailed Description

For the purposes, technical solutions and advantages of the embodiments of the present application to be more apparent, the specific technical solutions of the present application will be described in further detail below with reference to the accompanying drawings in the embodiments of the present application. The following examples are illustrative of the present application, but are not intended to limit the scope of the present application.

In the present embodiments, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the embodiments of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.

Furthermore, in the embodiments of the present application, the terms "upper," "lower," "left," and "right," etc., are defined with respect to the orientation in which the components in the drawings are schematically disposed, and it should be understood that these directional terms are relative terms, which are used for descriptive and clarity with respect to each other, and which may vary accordingly with respect to the orientation in which the components in the drawings are disposed.

In the embodiments herein, unless explicitly specified and limited otherwise, the term "connected" is to be construed broadly, and for example, "connected" may be either a fixed connection, a removable connection, or an integral body; can be directly connected or indirectly connected through an intermediate medium.

In the present embodiments, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.

In the embodiments of the present application, words such as "exemplary" or "such as" are used to mean serving as examples, illustrations, or descriptions. Any embodiment or design described herein as "exemplary" or "for example" should not be construed as preferred or advantageous over other embodiments or designs. Rather, the use of words such as "exemplary" or "such as" is intended to present related concepts in a concrete fashion.

Example 1

As shown in fig. 1 to 6, the structure diagram of the full-automatic miniature sample transmission detection system provided by the invention comprises: the device comprises a base 1, a supporting frame body 2 fixedly arranged at the top of the base 1, a supporting disc 3 rotatably arranged at the outer side of the top of the supporting frame body 2, a plurality of sample grooves 8 formed in the periphery of the top of the supporting disc 3 and used for fixing samples, a sample feeding mechanism 4 arranged at the side of the supporting disc 3 and used for pushing single samples into one of the sample grooves 8, a sample discharging mechanism 5 connected with the sample feeding mechanism 4 and used for pushing the detected samples out of the sample grooves 8, a driving mechanism 6 connected with the sample feeding mechanism 4 and capable of driving the sample feeding mechanism 4 and the sample discharging mechanism 5 to synchronously move, and a detection mechanism 7 arranged at the side of the supporting disc 3 and used for aligning the stationary sample grooves 8 to perform optical testing of the samples, wherein the driving mechanism 6 can also drive the supporting disc 3 to rotate at fixed angles to realize position switching of different sample grooves 8 after sample feeding and discharging actions are completed, and the sample feeding mechanism 4, the detection mechanism 7 and the sample discharging mechanism 5 are sequentially distributed along the rotation direction of the supporting disc 3.

In practical application, the supporting bracket body 2 is utilized to rotationally mount the supporting tray 3, and samples are fixed through the plurality of sample grooves 8 formed in the top of the supporting tray 3, so that the samples positioned in the sample grooves 8 can rotate along with the supporting tray 3; the detection mechanism 7 positioned beside the bearing tray 3 can be aligned to the sample tank 8 after the bearing tray 3 is static, and can perform optical detection analysis on the sample in the sample tank 8; the sample feeding mechanism 4 and the sample discharging mechanism 5 can feed or push a single sample into or out of the sample groove 8; because actuating mechanism 6 links to each other simultaneously with sampling mechanism 4 and play appearance mechanism 5, consequently can drive sampling mechanism 4 and play appearance mechanism 5 synchronous motion in order to realize the simultaneous business turn over sample of different position sample grooves 8, and actuating mechanism 6 can also drive the position switching of carrying tray 3 fixed angle rotation realization different sample grooves 8 after accomplishing business turn over appearance action, and carry out the detection of different sample inslot 8 sample through detection mechanism 7, consequently realized carrying the automatic transmission of sample on the dish 3, with detection mechanism 7 cooperation can realize the automatic transmission detection analysis of sample, also alleviateed staff's loaded down with trivial details operation when promoting detection efficiency, can satisfy the demand of batch detection.

Specifically, the system further includes a hollow casing 9, the base 1 is fixed on the bottom surface in the casing 9, the top surfaces of the supporting frame 2 and the supporting tray 3 both exceed the top surface of the casing 9, and the sample feeding mechanism 4 includes: the sample injection device comprises a sample injection guide 41 fixedly arranged on the top surface of the shell 9 and internally provided with an inclined channel for accommodating samples, a sample injection notch 42 which is arranged at the lower end of the sample injection guide 41 and can be opposite to the sample tank 8, and a sample injection assembly 43 which is opposite to the sample injection notch 42 and is used for intermittently pushing samples in the inclined channel into the sample tank 8.

It will be appreciated that by providing an inclined channel within the sample introduction guide 41 for receiving a sample, an initial potential energy can be imparted to the sample, and the sample within the inclined channel can be driven to be intermittently pushed into the sample well 8 by the alignment of the sample introduction assembly 43 with the sample introduction slot 42.

It should be noted that, in the actual operation process, the sample introduction guide 41 may be connected with an external conveying device, so that the sample to be detected is firstly conveyed into the inclined channel for being stored in advance, and a plurality of samples to be detected may be placed into the inclined channel in a manual manner, so as to cooperate with the sample introduction assembly 43 to realize sample introduction.

In addition, in the transmission detection system of the present application, in actual operation, a sample to be subjected to optical testing is generally placed inside a cuvette, and then finally conveyed to the inside of the sample tank 8 via the sample introduction guide 41 and the sample introduction assembly 43, and after the support tray 3 rotates to a proper position, the sample after detection is pushed out from the inside of the sample tank 8 by the sample ejection mechanism 5.

Further, the sample injection assembly 43 includes: the device comprises a sample injection limiting part 431 fixedly arranged on the outer side of the sample injection notch 42, a sample injection push rod 432 connected to the sample injection limiting part 431 in a sliding manner, and a sample injection unit 433 connected with the sample injection push rod 432 and used for driving the sample injection push rod 432 to reciprocate along the direction perpendicular to the sample injection notch 42 so as to realize intermittent sample injection.

It can be known that the sample injection push rod 432 is conveniently and slidably installed through the sample injection limiting member 431, so that under the action of the sample injection unit 433, the sample injection push rod 432 is driven to reciprocate along the direction perpendicular to the sample injection notch 42, so that a sample placed obliquely is pushed into the sample groove 8 at the periphery of the support plate 3 which is in a static state and opposite to the sample injection notch 42, and intermittent feeding is realized.

Further, the sample injection unit 433 includes: the rotary sampling rotary shaft 4331 is rotatably connected to the top of the base 1, a sampling rotary disc 4332 fixedly arranged at the top end of the sampling rotary shaft 4331 and the lower bottom surface of the rotary shaft exceeds the upper top surface of the casing 9, a sampling cylinder 4333 fixedly arranged at the eccentric position of the top of the sampling rotary disc 4332, and a sleeve connection part 4334 connected with one end of the sampling push rod 432 far away from the sampling notch 42 and sleeved outside the sampling cylinder 4333.

In practical application, the sample injection rotary table 4332 is driven to rotate by the rotating shaft, so as to drive the sample injection cylinder 4333 located at the eccentric position of the sample injection rotary table 4332 to rotate, and the sample injection push rod 432 is slidably connected with the sample injection limiting member 431, and the sleeve connection member 4334 connected with the sample injection push rod 432 is sleeved outside the sample injection cylinder 4333, so that the sample injection push rod 432 can be driven to slide along the sample injection limiting member 431 and push the sample to be transmitted into the sample tank 8.

The sample injection limiting member 431 may be a limiting plate fixed on the outer side of the sample injection notch 42, and a limiting groove opposite to the sample injection notch 42 is formed in the sample injection limiting member 431, so that the sample injection push rod 432 is slidably connected inside the limiting groove in a penetrating manner, and functions of guiding and limiting are performed; the socket 4334 may be an annular sleeve sleeved outside the sample injection cylinder 4333, so that the sample injection push rod 432, the socket 4334 and the sample injection cylinder 4333 form a scotch yoke mechanism, so as to realize the reciprocating linear motion of the sample injection push rod 432 along the limit groove inside the sample injection limit part 431.

It should be noted that, in addition to the eccentric rotary disc mechanism in the present application, the sample injection unit 433 may also use other reciprocating mechanisms, such as a telescopic cylinder or a screw-nut mechanism, so long as the reciprocating sample injection can be implemented, and the sample injection unit 433 of the present embodiment is not limited thereto.

In one case of the present embodiment, the sample introduction guide member 41 includes: the device comprises a bottom plate fixedly arranged on the upper top surface of the shell 9 and obliquely arranged, two side plates fixedly arranged on the top of the bottom plate and arranged at intervals in parallel, and a baffle fixedly arranged on the lower end of the top of the bottom plate, wherein a sample introduction notch 42 is formed in the lower ends of the two side plates, and inclined channels are formed between the inner walls of the side plates on two sides of the sample introduction guide 41 and the top surface of the bottom plate.

It can be known that the inclined channel is formed by the bottom plate and the side plate together, so that the initial potential energy of the sample is conveniently given, the lower sample is limited by the baffle plate, and the sample feeding assembly 43 is conveniently matched with the sample feeding assembly to finish the transmission of the detection sample.

In one case of the present embodiment, the detection mechanism 7 includes: the two supporting members 71 are respectively arranged at the top of the supporting frame body 2 and the top surface of the casing 9 and are positioned at two sides of the sample slot 8, each supporting member 71 is provided with an optical fiber port, one optical fiber port is connected with a light source through an optical fiber, the other optical fiber port is connected with an optical analysis instrument through an optical fiber, the sample slot 8 is positioned between the two optical fiber ports and can be aligned with the connecting lines of the two optical fiber ports so as to collect sample data, the sample introduction guide member 41, the detection member and the sample discharge guide member 57 are sequentially arranged along the rotation direction of the supporting disc 3, and the detection mechanism 7 is arranged between the sample introduction guide member 41 and the sample discharge guide member 57.

It can be known that the two supporting members 71 are distributed on both sides of the sample tank 8 by using the supporting members 71 fixed on the top surfaces of the supporting frame body 2 and the casing 9, wherein one of the optical fiber ports is connected with a light source through an optical fiber, and the other optical fiber port is connected with an optical analysis instrument through an optical fiber, so that light suitable for different sample experiments can be emitted by using the light source, transmitted to one of the optical fiber ports positioned beside the sample tank 8 through the optical fiber, reflected by the rear part of the sample and returned to the probe sampler position on the other optical fiber port, so that the optical analysis instrument can acquire a scattering spectrum with different frequency from the incident light, and analyze the scattering spectrum to obtain information about molecular vibration and rotation.

It should be noted that, because the tray 3 is rotatably installed at the outer side of the top of the supporting frame 2, the sample groove 8 is formed in the outer periphery of the top of the tray 3, two optical fiber ports respectively formed at the tops of the tray 3 and the casing 9 are distributed at two sides of the sample groove 8, and the sample is generally placed in the cuvette, so that the height of the cuvette needs to be set to be higher than the depth of the sample groove 8, and in actual operation, the depth of the sample groove 8 is generally set to be half of the height of the cuvette, thereby realizing detection requirements.

In one example of the invention, the support 71 may be two support plates fixed to the top of the support frame and the cabinet 9, respectively, and provided laterally with interfaces for threading optical fibers; the optical analysis instrument may be a portable raman spectrometer, the light source may be a halogen lamp, a deuterium tungsten lamp, or a mercury argon lamp, or may be a gas laser or a semiconductor laser, which is mainly selected according to the experimental requirements of different samples, and the embodiment is not limited specifically herein. A step of

Example 2

As shown in fig. 5, on the basis of embodiment 1, the supporting frame body 2 includes: the lower column body 21, the middle column body 22 and the upper column body 23 which are sequentially and fixedly connected and are hollow are arranged in the lower column body and the upper column body, the lower column body 21 is fixedly installed at the top of the base 1, the outer diameter of the middle column body 22 is smaller than that of the lower column body 21 and the outer diameter of the upper column body 23, the lower bottom surface of the upper column body 23 exceeds the upper top surface of the shell 9, the supporting disc 3 is rotationally sleeved outside the upper column body 23 and the middle column body 22 in part, and a through hole for accommodating the sample discharging mechanism 5 is formed in the upper column body 23 in a penetrating mode.

In practical application, the upper column 23 is arranged to facilitate the installation of the bearing plate 3, and the lower bottom surface of the upper column 23 exceeds the upper top surface of the casing 9, so that the bearing plate 3 can be arranged above the casing 9, and the sample feeding mechanism 4 and the sample discharging mechanism 5 can be arranged inside the casing 9, thereby avoiding the influence of leakage on the detection process of samples.

Further, the sample ejection mechanism 5 includes: the sample discharging rotary shaft 51 is rotatably installed at the top of the base 1 and located in the support frame body 2, the sample discharging rotary disc 52 is fixedly arranged at the upper end of the sample discharging rotary shaft 51 and is contained in the through hole, the sample discharging rotary disc 53 is fixedly arranged at the eccentric position of the top surface of the sample discharging rotary disc 52, one end of the sample discharging rotary disc is rotatably connected with the first sample discharging rotary rod 54 of the sample discharging rotary disc 53, the second sample discharging rotary rod 55 is rotatably connected with one end of the first sample discharging rotary rod 54 far away from the sample discharging rotary rod 53, the sample discharging limiting part 56 is fixedly arranged at the top surface of the upper cylinder 23 and is in sliding connection with the second sample discharging rotary rod 55, and the sample discharging guide part 57 is fixedly arranged at the top surface of the shell 9, the sample discharging guide part 57 is located at the outer side of the support disc 3 and is internally provided with a sample discharging channel opposite to the second sample discharging rotary rod 55, one side of the lower cylinder 21 is provided with an opening, and the sample discharging rotary shaft 51 is connected with the sample discharging rotary shaft 4331 through a belt wheel set passing through the opening to realize synchronous rotation.

In the embodiment, during actual operation, the sample discharging rotary shaft 51 is utilized to rotate to drive the sample discharging cylinder 53 to rotate, so as to drive the first transmission rotary rod to rotate, and drive the second sample discharging rotary rod 55 to reciprocate along the sample discharging limiting piece 56 to send the detected sample inside the sample tank 8 into the sample discharging channel of the sample discharging guide piece 57, so that the sample discharging process is completed, and since the opening is formed on one side of the lower cylinder 21, the sample discharging process can be completed by connecting the belt wheel set with the sample feeding rotary shaft 4331 to realize synchronous rotation, and synchronous sample feeding and synchronous sample discharging actions are completed.

In one aspect of this embodiment, the pulley set includes: the sample feeding device comprises a sample feeding belt wheel fixedly sleeved on the sample feeding rotating shaft 4331, a sample discharging belt wheel fixedly sleeved on the sample discharging rotating shaft 51 and positioned in the lower column 21, and a belt connected between the sample feeding belt wheel and the sample discharging belt wheel and penetrating out of the opening.

It can be known that the pulley set is used to connect the sample feeding shaft 4331 and the sample discharging shaft 51 together, so that the two shafts are synchronously rotated under the drive of the driving mechanism 6.

In this embodiment, during actual operation, the sample discharging turntable 52 is disposed inside the through hole, and its diameter may be slightly smaller than the inner diameter of the through hole, and the first sample discharging rotating rod 54, the second sample discharging rotating rod 55, the sample discharging turntable 52 and the sample discharging limiting member 56 together form a crank slider mechanism, so that the sample inside the sample tank 8 is pushed into the sample discharging guide 57.

The sample-discharging limiting member 56 may be a limiting member fixed on the top of the upper cylinder 23, and a groove for slidably penetrating the second sample-discharging rotating rod 55 is formed in the sample-discharging limiting member, the second sample-discharging rotating rod 55 is constrained by the groove, and only one degree of freedom moves, so that the detected sample is aligned to the sample-discharging guiding member 57, the sample-discharging guiding member 57 may be similar to the sample-feeding guiding member 41 in structure, two ends of the sample-discharging guiding member are penetrated, and a planar channel is formed in the sample-discharging guiding member, so that the sample-discharging guiding member can be matched with other conveying devices to realize the transmission and guiding of the sample.

Specifically, sample reservoirs corresponding to the sample introduction guide member 41 and the sample discharge guide member 57 may be disposed beside the sample introduction guide member 41 and the sample discharge guide member 57, so as to store the sample to be detected and the sample after detection.

Example 3

As shown in fig. 3 to 8, on the basis of embodiment 1 and embodiment 2, the support tray 3 includes: the lower and upper parts are sequentially connected with the guide post 31 and the tray body 32, the guide post 31 is hollow and rotationally sleeved outside the middle column 22, the tray body 32 is rotationally sleeved outside the upper column 23 and the top surface is flush with the top surface of the upper column 23, and the sample groove 8 is formed in the periphery of the top of the tray body 32.

Specifically, the supporting disc 3 is arranged to be the guide pillar 31 and the disc 32, so that the sample groove 8 is conveniently formed by using the disc 32, the whole supporting disc 3 is connected with the middle column 22 through the guide pillar 31 to rotate by being connected with the driving mechanism 6, the top surface of the disc 32 is flush with the top surface of the upper column 23, the second sample discharging rotating rod 55 can be conveniently aligned with the sample groove 8, and the cuvette in the sample groove 8 can be pushed out by using the second sample discharging rotating rod 55 because the height of the cuvette for placing the sample is larger than that of the sample groove 8.

Further, the sample grooves 8 are formed in an annular array at the top of the tray body 32 and extend radially inward from the outer wall of the tray body 32 for a certain distance, the sample grooves 8 are uniformly distributed along the circumferential direction of the tray body 32, and elastic pieces 33 for fixing samples are mounted on the inner walls of two sides of each sample groove 8.

It can be known that, since the sample grooves 8 are formed in the annular array at the top of the tray body 32 and are uniformly distributed along the axial direction of the tray body 32, the sample grooves can be matched with the sample feeding mechanism 4 and the sample discharging mechanism 5 to realize intermittent sample feeding and sample discharging of the corresponding sample grooves 8, and the sample feeding grooves extend a certain distance from the outer wall of the tray body 32 along the radial inward direction, so that the sample grooves 8 have enough space for accommodating samples, the elastic pieces 33 for fixing the samples are mounted on the inner walls of the two sides of each sample groove 8, the samples entering the sample grooves 8 can be simply fixed, and the samples are prevented from falling out from the sample grooves 8 in the rotation process of the supporting tray 3.

Still further, the driving mechanism 6 includes: the device comprises a driving motor fixedly arranged in a base 1, a driving shaft 62 connected with the output end of the driving motor, a sample injection intermittent gear 63 and a rotary disc intermittent gear 64 which are sequentially and fixedly sleeved on the driving shaft 62 along the axial direction, a sample injection gear 65 fixedly sleeved on a sample injection rotating shaft 4331 and meshed with the sample injection intermittent gear 63, and a rotary disc gear 66 fixedly sleeved on the outer side of a disc body 32 and meshed with the rotary disc intermittent gear 64, wherein the sample injection intermittent gear 63 and the rotary disc intermittent gear 64 are incomplete gears and are arranged in a staggered mode, and a bearing 61 which is rotatably sleeved on the middle column 22 and is propped against the top surface of the lower column 21 is fixedly connected below the rotary disc gear 66.

In the embodiment, during actual operation, the driving shaft 62 is driven by the driving motor to rotate, so that the sample feeding intermittent gear 63 and the rotary disc intermittent gear 64 are driven to rotate, and the sample feeding gear 65 and the rotary disc gear 66 can be driven to rotate successively because the sample feeding rotary shaft 4331 and the sample discharging rotary shaft 51 are connected by the belt pulley group, so that sample feeding and discharging actions are performed simultaneously, and the rotary disc gear 66 of the sample feeding gear 65 rotates successively, so that after sample feeding and discharging actions are completed, the driving shaft 62 can also drive the rotary disc gear 66 to rotate through the rotary disc intermittent gear 64, and further drive the tray 3 to rotate so as to realize the position switching of the sample groove 8; the sample feeding mechanism 4, the detection mechanism 7 and the sample discharging mechanism 5 are sequentially distributed along the rotation direction of the supporting plate 3, so that samples entering the sample tank 8 can be ensured to be tested by the detection mechanism 7 and then conveyed out by the sample discharging mechanism 5.

It should be noted that, the driving mechanism 6 of the application adopts a driving motor to realize the simultaneous sample inlet and outlet actions and the subsequent switching actions of the sample tank 8, the transmission process is more reliable, and each mechanism moves in a coordinated manner, so that the high automation of the sample transmission process is realized, and the tedious operation of researchers in the sample detection process is reduced.

The elastic member 33 may be a spring piece or a compression spring fixed on the inner walls of the two sides of the sample tank 8, and the driving motor may be a stepper motor or a servo motor, preferably a stepper motor; the sample feeding intermittent gear 63 and the turntable intermittent gear 64 are fixed on the driving shaft 62 by adopting a pin structure.

In one case of this embodiment, the number of sample slots 8 on the support tray 3 may be set to 16, and if the number of the sample slots 8 is 1 at the position of the sample slot 42 on the sample guide 41, the sample slots 8 are numbered from small to large in anticlockwise direction, then the support members 71 are installed on the inner and outer sides of the 8 th sample slot 8, and the optical fiber ports are provided, and the sample guide 57 is fixedly installed on the casing 9 outside the 13 th sample slot 8, and the sample stop member 56 is fixedly installed on the support frame 2 inside the sample slot 8, so as to implement the sample transmission function; of course, the number of the sample wells 8 may be selected as needed, and the present embodiment is not particularly limited herein.

In another case of this embodiment, the original teeth numbers of the turntable intermittent gear 64 and the turntable gear 66 are 16 teeth, but for the purpose of intermittent motion, the turntable intermittent gear 645 needs to remove 15 teeth and becomes a 1-tooth gear; the sample feeding intermittent gear 63 and the sample feeding gear 65 are all gears with the modulus of 3; the number of teeth of the sample injection gear 6511 is 10, and the teeth are uniformly distributed on the periphery of the sample injection gear 6511; the number of teeth of the sample intermittent gear 636 is 30, but for intermittent purposes, 20 teeth are removed and changed into 10 teeth gears, and the number of teeth of each gear in this embodiment is not limited as long as the intermittent transmission function can be satisfied.

In actual operation, the invention can also realize the requirement of detecting a plurality of samples at the same time by increasing the relation between the optical fiber port and the gear teeth number and the transmission ratio, thereby achieving the requirement of high flux.

In the above embodiment of the present invention, a fully automatic miniature sample transmission detection system is provided, in which a supporting bracket body 2 is used to rotatably mount a supporting tray 3, and samples are fixed by a plurality of sample grooves 8 formed on the top of the supporting tray 3, so that samples located in the sample grooves 8 can rotate along with the supporting tray 3; the detection mechanism 7 positioned beside the bearing tray 3 can be aligned to the sample tank 8 after the bearing tray 3 is static, and can perform optical detection analysis on the sample in the sample tank 8; the sample feeding mechanism 4 and the sample discharging mechanism 5 can feed or push a single sample into or out of the sample groove 8; because actuating mechanism 6 links to each other simultaneously with sampling mechanism 4 and play appearance mechanism 5, consequently can drive sampling mechanism 4 and play appearance mechanism 5 synchronous motion in order to realize the simultaneous business turn over sample of different position sample grooves 8, and actuating mechanism 6 can also drive the position switching of carrying tray 3 fixed angle rotation realization different sample grooves 8 after accomplishing business turn over appearance action, and carry out the detection of different sample inslot 8 sample through detection mechanism 7, consequently realized carrying the automatic transmission of sample on the dish 3, with detection mechanism 7 cooperation can realize the automatic transmission detection analysis of sample, also alleviateed staff's loaded down with trivial details operation when promoting detection efficiency, can satisfy the demand of batch detection.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

Claims (10)

1. A fully automatic miniature sample transmission detection system, comprising: base (1), set firmly in support body (2) at base (1) top, rotate install in support body (2) top outside supporting disk (3), set up in supporting disk (3) top periphery and be used for a plurality of sample grooves (8) of fixed sample, locate supporting disk (3) side just are used for carrying out sample mechanism (4) inside one of them sample groove (8) with single sample propelling movement, with sample mechanism (4) link to each other and be used for pushing out sample after detecting sample mechanism (5) of sample groove (8), with sample mechanism (4) link to each other and can drive sample mechanism (4) and sample mechanism (5) synchronous motion's actuating mechanism (6), and locate supporting disk (3) side just are used for aligning detection mechanism (7) of sample groove (8) after stationary in order to carry out sample optical test, actuating mechanism (6) still can drive supporting disk (3) and decide the angle rotation in order to realize the switching of the position of different sample grooves (8), detection mechanism (4), detection mechanism (7) and supporting disk (3) are followed sample mechanism (5) and sample mechanism (3) rotate in proper order and are followed and are rotated in the direction.

2. The fully automatic miniature sample transmission detection system according to claim 1, further comprising a housing (9) having a hollow interior, wherein the base (1) is fixed to an inner bottom surface of the housing (9), the top surfaces of the support frame (2) and the support tray (3) both exceed the top surface of the housing (9), and the sample feeding mechanism (4) comprises: the sample injection device comprises a sample injection guide (41) fixedly arranged on the top surface of a shell (9) and internally provided with an inclined channel for accommodating samples, a sample injection notch (42) which is arranged at the lower end of the sample injection guide (41) and can be opposite to the sample tank (8), and a sample injection assembly (43) which is opposite to the sample injection notch (42) and is used for intermittently pushing samples in the inclined channel into the sample tank (8).

3. The fully automated miniature sample transmission detection system of claim 2, wherein the sample introduction assembly (43) comprises: the sampling device comprises a sampling limiting part (431) fixedly arranged on the outer side of the sampling notch (42), a sampling push rod (432) connected with the sampling limiting part (431) in a sliding mode, and a sampling unit (433) connected with the sampling push rod (432) and used for driving the sampling push rod (432) to reciprocate along the direction perpendicular to the sampling notch (42) so as to realize intermittent sampling.

4. A fully automated micro sample transfer inspection system according to claim 3, wherein the sample introduction unit (433) comprises: the rotary sampling rotary table comprises a sampling rotary shaft (4331) rotatably connected to the top of the base (1), a sampling rotary table (4332) fixedly arranged at the top end of the sampling rotary shaft (4331) and the lower bottom surface of the sampling rotary shaft exceeds the upper top surface of the shell (9), a sampling cylinder (4333) fixedly arranged at the eccentric position of the top of the sampling rotary table (4332), and a sleeve joint piece (4334) connected with one end of a sampling push rod (432) away from the sampling notch (42) and sleeved outside the sampling cylinder (4333).

5. A fully automatic miniature sample transmission detection system according to claim 4, characterized in that the support frame (2) comprises: lower cylinder (21), well cylinder (22) and last cylinder (23) by lower and last fixed connection in proper order and inside all cavity setting, lower cylinder (21) fixed mounting in base (1) top, the external diameter of well cylinder (22) is less than the external diameter of lower cylinder (21) and last cylinder (23), go up the bottom surface under cylinder (23) and surpass the last top surface of casing (9), bearing dish (3) rotate the cover and establish in last cylinder (23) and the part cylinder (22) outside, go up cylinder (23) inside and run through and offer and be used for holding go out the through-hole of appearance mechanism (5).

6. A fully automatic miniature sample transmission detection system according to claim 5, wherein said sample ejection mechanism (5) comprises: the sample discharging rotary shaft (51) arranged at the top of the base (1) and positioned in the support frame body (2), the sample discharging rotary shaft (51) is fixedly arranged at the upper end of the sample discharging rotary shaft (51) and is fixedly arranged in a sample discharging rotary disc (52) in the through hole, a sample discharging rotary shaft (53) arranged at the eccentric position of the top surface of the sample discharging rotary disc (52), a first sample discharging rotary rod (54) with one end rotationally connected with the sample discharging rotary shaft (53), a second sample discharging rotary rod (55) rotationally connected with the first sample discharging rotary rod (54) and far away from one end of the sample discharging rotary shaft (53), a sample discharging limiting part (56) fixedly arranged at the top surface of the upper cylinder (23) and in sliding connection with the second sample discharging rotary rod (55), and a sample discharging guide part (57) fixedly arranged at the top surface of the shell (9), wherein one side of the lower cylinder (21) is provided with an opening, and the sample discharging rotary shaft (51) is connected with the sample discharging rotary shaft (4331) in a synchronous mode.

7. A fully automated miniature sample transfer inspection system according to claim 5, wherein said holding tray (3) comprises: the device comprises a guide pillar (31) and a tray body (32) which are sequentially connected from bottom to top, wherein the guide pillar (31) is hollow and rotationally sleeved outside the middle column body (22), the tray body (32) is rotationally sleeved outside the upper column body (23) and the top surface of the tray body is flush with the top surface of the upper column body (23), and the sample groove (8) is formed in the periphery of the top of the tray body (32).

8. The full-automatic miniature sample transmission detection system according to claim 7, wherein the sample grooves (8) are formed in an annular array on the top of the tray body (32) and extend inward from the outer wall of the tray body (32) along the radial direction for a certain distance, the sample grooves (8) are uniformly distributed along the circumferential direction of the tray body (32), and elastic pieces (33) for fixing samples are mounted on the inner walls of two sides of each sample groove (8).

9. A fully automated micro sample transfer inspection system according to claim 7, wherein the drive mechanism (6) comprises: the device comprises a driving motor, a driving shaft (62), a sampling intermittent gear (63) and a rotary disc intermittent gear (64), a sampling gear (65) and a rotary disc gear (66), wherein the driving motor is fixedly arranged inside a base (1), the driving shaft (62) is connected with the output end of the driving motor, the sampling intermittent gear (63) and the rotary disc intermittent gear (64) are sequentially and fixedly sleeved on the driving shaft (62) along the axial direction, the sampling gear (65) is fixedly sleeved on a sampling rotating shaft (4331) and meshed with the sampling intermittent gear (63), the rotary disc gear (66) is fixedly sleeved on the outer side of a disc body (32) and meshed with the rotary disc intermittent gear (64), the sampling intermittent gear (63) and the rotary disc intermittent gear (64) are incomplete gears and are distributed in gear teeth dislocation, and a bearing (61) which is fixedly connected with the rotary sleeve below the rotary disc gear (66) and is arranged on the middle cylinder (22) and is abutted against the top surface of the lower cylinder (21).

10. A fully automated micro sample transfer assay system according to any one of claims 2-9, wherein the assay mechanism (7) comprises: two support pieces (71) which are respectively arranged at the top of the support frame body (2) and the top surface of the shell (9) and are positioned at two sides of the sample groove (8), and each support piece (71) is provided with an optical fiber port, one optical fiber port is connected with a light source through an optical fiber, the other optical fiber port is connected with an optical analysis instrument through an optical fiber, and the sample groove (8) is positioned between the two optical fiber ports and can be aligned with the two optical fiber ports through a connecting line so as to realize the acquisition of sample information.