CN116492268A - Hand washing disinfection effervescent tablet and preparation method thereof - Google Patents
Hand washing disinfection effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN116492268A CN116492268A CN202310742782.5A CN202310742782A CN116492268A CN 116492268 A CN116492268 A CN 116492268A CN 202310742782 A CN202310742782 A CN 202310742782A CN 116492268 A CN116492268 A CN 116492268A
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- China
- Prior art keywords
- attapulgite
- effervescent tablet
- parts
- washing
- hand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000005406 washing Methods 0.000 title claims abstract description 56
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 13
- 229960000892 attapulgite Drugs 0.000 claims abstract description 70
- 229910052625 palygorskite Inorganic materials 0.000 claims abstract description 70
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 26
- 230000000249 desinfective effect Effects 0.000 claims abstract description 24
- 229920001690 polydopamine Polymers 0.000 claims abstract description 21
- 102000016943 Muramidase Human genes 0.000 claims abstract description 16
- 108010014251 Muramidase Proteins 0.000 claims abstract description 16
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 16
- 239000004325 lysozyme Substances 0.000 claims abstract description 16
- 229960000274 lysozyme Drugs 0.000 claims abstract description 16
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 16
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 13
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 13
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 claims abstract description 12
- 229940075468 lauramidopropyl betaine Drugs 0.000 claims abstract description 12
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims abstract description 12
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 8
- 239000000419 plant extract Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 17
- 239000012065 filter cake Substances 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 239000003607 modifier Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000001914 filtration Methods 0.000 claims description 11
- NSDWMQZDGGQRLM-UHFFFAOYSA-N 4-chlorobutan-1-amine;hydrochloride Chemical compound Cl.NCCCCCl NSDWMQZDGGQRLM-UHFFFAOYSA-N 0.000 claims description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 10
- WUPVYJJCKYSGCR-UHFFFAOYSA-M sodium;3-oxoisoindol-1-olate Chemical compound [Na+].C1=CC=C2C(=O)[N-]C(=O)C2=C1 WUPVYJJCKYSGCR-UHFFFAOYSA-M 0.000 claims description 10
- CTENFNNZBMHDDG-UHFFFAOYSA-N Dopamine hydrochloride Chemical compound Cl.NCCC1=CC=C(O)C(O)=C1 CTENFNNZBMHDDG-UHFFFAOYSA-N 0.000 claims description 9
- 229940119217 chamomile extract Drugs 0.000 claims description 9
- 235000020221 chamomile extract Nutrition 0.000 claims description 9
- 229960001149 dopamine hydrochloride Drugs 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 239000003826 tablet Substances 0.000 claims description 9
- 239000007983 Tris buffer Substances 0.000 claims description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 6
- 239000012747 synergistic agent Substances 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 239000004166 Lanolin Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 229940039717 lanolin Drugs 0.000 claims description 2
- 235000019388 lanolin Nutrition 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005202 decontamination Methods 0.000 abstract description 8
- 230000003588 decontaminative effect Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- -1 synergist Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000000645 desinfectant Substances 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 229940069521 aloe extract Drugs 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000001816 cooling Methods 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 239000004927 clay Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000010705 motor oil Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000007547 defect Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- AVBJHQDHVYGQLS-AWEZNQCLSA-N (2s)-2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-AWEZNQCLSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention provides a hand washing and disinfecting effervescent tablet and a preparation method thereof, wherein the hand washing and disinfecting effervescent tablet comprises the following components: plant extract, lysozyme, humectant, sodium cocoyl glycinate, lauramidopropyl betaine, synergist, sodium bicarbonate and citric acid. The synergist is modified attapulgite modified by polydopamine, a three-dimensional network structure can be formed on the surface of skin, the affinity of the attapulgite to the skin is obviously improved, the adhesion of the skin to the attapulgite is promoted, the utilization rate of the attapulgite is improved, the adsorption of a system to dirt is further improved, and the decontamination effect is further improved.
Description
Technical Field
The invention relates to the technical field of hand washing products, in particular to a hand washing and disinfecting effervescent tablet and a preparation method thereof.
Background
The hand cleanser is a skin care cleaning liquid for cleaning hands, and comprises specific components which can perform the functions of disinfection and sterilization by using mechanical friction and the function of a surfactant, and water flow or water is not needed to remove dirt and attached bacteria on the hands, wherein the hand cleanser comprises common hand cleanser, foam hand cleanser, common/foam antibacterial hand cleanser and the like, mainly comprises water-based hand cleanser with the surfactant, and bubbles can be generated in the cleaning process; there is another type of leave-on liquid which is mainly a gel leave-on liquid consisting of 75% alcohol, without foam during cleaning.
Most of the hand sanitizer products in the current market are liquid heterogeneous systems, and have the defects of large volume, inconvenient carrying, transportation and storage, easy leakage, poor physical stability and the like.
The effervescent tablet is taken as a mature pharmaceutical dosage form, takes the reaction of organic acid and basic (hydrogen) carbonate as an effervescent disintegrating agent, is put into water, immediately generates effervescent reaction, generates and releases a large amount of carbon dioxide gas, and has the advantages of rapid disintegration, convenient storage, transportation and use, simple preparation process and the like.
CN110755271a discloses a hand sanitizer effervescent tablet and a preparation method thereof, and the hand sanitizer effervescent tablet comprises the following components: 10 to 30 parts of fumaric acid, 25 to 75 parts of ammonium bicarbonate, 5 to 15 parts of polyethylene glycol, 4 to 12 parts of sodium dodecyl sulfate, 3 to 9 parts of fatty alcohol polyvinyl ether sodium sulfate, 2.5 to 7.5 parts of lauroyl glutamic acid and 0.5 to 1.5 parts of essential oil, firstly, mixing baking soda, polyethylene glycol and coconut oil into a high-speed granulator with the rotating speed of 500 to 3000 revolutions for 20 to 40 minutes uniformly; then adding the components simultaneously to prepare particles with 20-60 meshes; then pressing into a wafer with the diameter of 2 cm and the thickness of 1cm by using a die; finally, adjusting the temperature to 40-60 ℃ for drying; and (5) drying and packaging the finished product. According to the invention, the traditional liquid hand sanitizer is prepared into the solid effervescent tablet, so that the situation of pouring and leakage of the traditional liquid hand sanitizer is avoided, and meanwhile, the solid liquid hand sanitizer effervescent tablet can be rapidly dissolved in water through the components of the effervescent tablet, and is convenient to carry and use. However, the decontamination effect of the decontamination component used in the patent is poor, and stains such as sludge, oil stains, paint and the like in some special industries are difficult to remove.
Disclosure of Invention
In view of the above, the invention provides a hand washing and disinfecting effervescent tablet with strong detergency and a preparation method thereof.
The technical scheme of the invention is realized as follows:
in one aspect, the invention provides a hand washing and disinfecting effervescent tablet, which comprises the following components: plant extract, lysozyme, humectant, sodium cocoyl glycinate, lauramidopropyl betaine, synergist, sodium bicarbonate and citric acid.
On the basis of the technical scheme, the hand washing and disinfecting effervescent tablet preferably comprises the following components in parts by weight: 1-5 parts of plant extract, 1-3 parts of lysozyme, 1-3 parts of humectant, 5-10 parts of sodium cocoyl glycinate, 5-10 parts of lauramidopropyl betaine, 3-5 parts of synergist, 5-15 parts of sodium bicarbonate and 5-15 parts of citric acid.
On the basis of the technical scheme, preferably, the mass ratio of the plant extract is 2-3:1-2 and chamomile extract.
On the basis of the technical scheme, preferably, the humectant is one or a mixture of more of glycerin, 1, 3-propylene glycol, lanolin, vaseline and hyaluronic acid.
On the basis of the technical scheme, preferably, the synergistic agent is modified attapulgite, and the preparation method comprises the following steps:
x1, grinding and sieving attapulgite, and then placing the attapulgite in a phosphoric acid aqueous solution for soaking, washing and roasting to obtain pretreated attapulgite;
x2, mixing 4-chlorobutylamine hydrochloride, phthalimide sodium salt and water for reaction to obtain a modifier;
and X3, mixing the modifier, the pretreated attapulgite and the N, N-dimethylformamide for reaction, filtering after the reaction is finished, collecting a filter cake, washing, and mixing the filter cake, protocatechuic acid and ethanol for reaction to obtain the modified attapulgite.
Based on the technical scheme, it is further preferable that the dosage ratio of the attapulgite to the phosphoric acid aqueous solution in the step X1 is 2-3g:30-50mL, and the concentration of the phosphoric acid aqueous solution is 10-30wt%.
Based on the technical scheme, it is further preferable that the dosage ratio of the 4-chlorobutylamine hydrochloride, the phthalimide sodium salt and the water in the step X2 is 3-8g to 1g to 10-20mL.
Based on the technical scheme, it is further preferable that the dosage ratio of the modifier, the pretreated attapulgite, the N, N-dimethylformamide, the protocatechuic acid and the absolute ethyl alcohol in the step X3 is 5-15g:3-8g:50-150mL:2-3g:200-300mL.
On the basis of the technical scheme, it is further preferable that the modified attapulgite is polydopamine modified attapulgite, and the preparation method comprises the following steps:
preparing dopamine hydrochloride aqueous solution by X4, and adding Tris buffer solution for heating reaction to obtain polydopamine;
and X5, adding the modified attapulgite into absolute ethyl alcohol, uniformly stirring, and adding polydopamine for heating reaction to obtain polydopamine modified attapulgite.
On the basis of the technical scheme, preferably, the concentration of the dopamine hydrochloride solution in the X4 step is 20-30wt%, and the dosage ratio of the dopamine hydrochloride solution to the Tris buffer solution is 2-4:1-3.
On the basis of the technical scheme, preferably, the dosage ratio of the modified attapulgite, the absolute ethyl alcohol and the polydopamine in the X5 step is 5-10g:50-100mL:1-2g.
In a second aspect, the invention also provides a preparation method of the hand washing and disinfecting effervescent tablet, which comprises the following steps:
s1, weighing the components according to a formula, and placing a humectant, sodium cocoyl glycinate and lauramidopropyl betaine into a mixer to be mixed and stirred for 10-20min at 10-40 ℃;
s2, adding the plant extract, the lysozyme and the synergistic agent into a mixer, and continuously stirring for 10-20min at the temperature of 10-40 ℃;
s3, adding sodium bicarbonate and citric acid into the mixer, and stirring for 5-10min at 10-40 ℃ to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting to obtain the hand-washing disinfection effervescent tablet.
In a third aspect, the invention also provides a using method of the hand washing and disinfecting effervescent tablet: dissolving 1-2 tablets of the hand washing and disinfecting effervescent tablet in 500-1000mL of water to obtain disinfectant, then taking 2-3mL of disinfectant to be placed in the palm center, rubbing the hands with each other to form foam, enabling the foam to be uniformly coated on each part of the hands, rubbing for 1-2min, and then washing with clear water.
Compared with the prior art, the hand washing and disinfecting effervescent tablet and the preparation method thereof have the following beneficial effects:
(1) The modifier prepared from 4-chlorobutylamine hydrochloride and phthalimide sodium salt is inserted into the interlayer of the attapulgite for modification, so that the defect that the attapulgite is easy to agglomerate is avoided, and the dispersion of the attapulgite in a system is promoted; the protocatechuic acid is grafted on the surface, so that the solubility is improved, and lysozyme can be better loaded, so that the bacteria can be better inhibited, and meanwhile, the functionalized attapulgite can be further penetrated into the texture of the skin surface to adsorb dirt in the kneading process, so that the decontamination effect is improved;
(2) The modified attapulgite is modified by polydopamine, so that a three-dimensional network structure can be formed on the surface of the skin, the affinity between the attapulgite and the skin is remarkably improved, the adhesion of the skin to the attapulgite is promoted, the utilization rate of the attapulgite is improved, the adsorption of a system to dirt is further improved, and the decontamination effect is further improved.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a perspective view of the hand washing and disinfecting effervescent tablet of the present invention.
Detailed Description
The following description of the embodiments of the present invention will clearly and fully describe the technical aspects of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, are intended to fall within the scope of the present invention.
The sources of part of raw materials used in the invention are as follows:
the aloe extract is an aqueous extract, 80 meshes, specification of 10:1, and is available from Sian Biotechnology Co., ltd.
Chamomile extract is water extract, 80 mesh, specification 10:1, shaanxi Xintian field biotechnology Co.
Lysozyme, the enzyme activity value is 200 ten thousand U/mg, shandong Siyang Biotechnology Co.
Example 1
A preparation method of a hand washing and disinfecting effervescent tablet comprises the following steps:
s1, placing 200g of glycerol, 800g of sodium cocoyl glycinate and 800g of lauramidopropyl betaine into a mixer, and mixing and stirring for 15min at 25 ℃;
s2, adding 187.5g of aloe extract, 112.5g of chamomile extract, 200g of lysozyme and 400g of synergist into a mixer, and continuously stirring for 15min at 25 ℃;
s3, adding 1000g of sodium bicarbonate and 1000g of citric acid into the mixer, and stirring at 25 ℃ for 7.5min to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting at 50 ℃ for 6 hours to obtain the hand-washing disinfection effervescent tablet; the size of the effervescent tablet is 2.6cm multiplied by 1cm.
The synergist is polydopamine modified attapulgite, and the preparation method comprises the following steps:
x1, grinding 100g of attapulgite, sieving with a 100-mesh sieve, soaking in a 20wt% phosphoric acid aqueous solution for 1h, filtering, collecting filter residues, washing the filter residues with water until the pH value is 7, and roasting at 300 ℃ for 2h to obtain pretreated attapulgite;
x2, mixing 50g of 4-chlorobutylamine hydrochloride, 10g of phthalimide sodium salt and 150mL of water, heating to 100 ℃ for reaction for 2-4h, cooling to room temperature after the reaction is finished, filtering, collecting a filter cake, washing the filter cake with water for 3 times, and drying at 50 ℃ for 8h to obtain a modifier;
x3, mixing 10g of modifier, 5g of pretreated attapulgite and 100mL of N, N-dimethylformamide, heating to 110 ℃ for reaction for 4-6 hours, cooling to room temperature after the reaction is finished, filtering, collecting a filter cake, washing the filter cake with tetrahydrofuran for 3 times, drying at 60 ℃ for 6 hours, mixing the filter cake, 3g of protocatechuic acid and 250mL of absolute ethyl alcohol, stirring at room temperature for reaction for 2 hours, filtering, collecting filter residues, washing the filter residues with water for 3 times, and drying at 60 ℃ for 8 hours to obtain modified attapulgite;
x4 is prepared into 200mL of 30wt% dopamine hydrochloride aqueous solution, and 150mL of Tris buffer solution is added for heating
Reacting at 40 ℃ for 2 hours, centrifuging at 2000rpm for 2 minutes, collecting solid matters, washing the solid matters with water for 3 times, and freeze-drying at-40 ℃ for 24 hours to obtain polydopamine;
x5, adding 7.5g of the modified attapulgite obtained in the step S3 into 75mL of absolute ethyl alcohol, uniformly stirring, adding 1.5g of polydopamine, heating to 90 ℃ for reaction for 12 hours, cooling to room temperature, filtering, collecting a filter cake, and drying the filter cake at 70 ℃ for 8 hours to obtain the polydopamine modified attapulgite.
Example 2
A preparation method of a hand washing and disinfecting effervescent tablet comprises the following steps:
s1, placing 200g of glycerol, 800g of sodium cocoyl glycinate and 800g of lauramidopropyl betaine into a mixer, and mixing and stirring for 15min at 25 ℃;
s2, adding 187.5g of aloe extract, 112.5g of chamomile extract, 200g of lysozyme and 400g of synergist into a mixer, and continuously stirring for 15min at 25 ℃;
s3, adding 1000g of sodium bicarbonate and 1000g of citric acid into the mixer, and stirring at 25 ℃ for 7.5min to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting at 50 ℃ for 6 hours to obtain the hand-washing disinfection effervescent tablet; the size of the effervescent tablet is 2.6cm multiplied by 1cm.
The synergistic agent is modified attapulgite, and the preparation method comprises the following steps:
x1, grinding 100g of attapulgite, sieving with a 100-mesh sieve, soaking in a 20wt% phosphoric acid aqueous solution for 1h, filtering, collecting filter residues, washing the filter residues with water until the pH value is 7, and roasting at 300 ℃ for 2h to obtain pretreated attapulgite;
x2, mixing 50g of 4-chlorobutylamine hydrochloride, 10g of phthalimide sodium salt and 150mL of water, heating to 100 ℃ for reaction for 2-4h, cooling to room temperature after the reaction is finished, filtering, collecting a filter cake, washing the filter cake with water for 3 times, and drying at 50 ℃ for 8h to obtain a modifier;
x3, mixing 10g of modifier, 5g of pretreated attapulgite and 100mL of N, N-dimethylformamide, heating to 110 ℃ for reaction for 4-6 hours, cooling to room temperature after the reaction is finished, filtering, collecting a filter cake, washing the filter cake with tetrahydrofuran for 3 times, drying at 60 ℃ for 6 hours, mixing the filter cake, 3g of protocatechuic acid and 250mL of absolute ethyl alcohol, stirring at room temperature for reaction for 2 hours, filtering, collecting filter residues, washing the filter residues with water for 3 times, and drying at 60 ℃ for 8 hours to obtain the modified attapulgite.
Example 3
A preparation method of the hand washing disinfection effervescent tablet is the same as that of example 1, and is characterized in that the dosage of glycerin is 100g, the dosage of sodium cocoyl glycinate is 500g, the dosage of lauramidopropyl betaine is 500g, the dosage of aloe extract is 67g, the dosage of chamomile extract is 33g, the dosage of lysozyme is 100g, the dosage of synergist is 300g, the dosage of sodium bicarbonate is 500g, the dosage of citric acid is 500g, the mixing temperature in step S1 is 10 ℃, the mixing and stirring are carried out for 10min, the mixing temperature in step S2 is 10 ℃, the mixing and stirring are carried out for 10min, the mixing temperature in step S3 is 10 ℃, the mixing and stirring are carried out for 5min, the dosage ratio of attapulgite to phosphoric acid aqueous solution in step X1 is 2g to 30mL, and the concentration of phosphoric acid aqueous solution is 10wt%; in the step X2, the dosage ratio of 4-chlorobutylamine hydrochloride, phthalimide sodium salt and water is 3g to 1g to 10mL; in the step X3, the dosage ratio of the modifier to the pretreated attapulgite to the N, N-dimethylformamide to the protocatechuic acid to the absolute ethyl alcohol is 5g to 3g to 50mL to 2g to 200mL; in the X4 step, the concentration of the dopamine hydrochloride aqueous solution is 20 weight percent, and the dosage ratio of the dopamine hydrochloride aqueous solution to the Tris buffer solution is 2:1, a step of; in the X5 step, the dosage ratio of the modified attapulgite to the absolute ethyl alcohol to the polydopamine is 5g:50mL:1g.
Example 4
A preparation method of the hand washing and disinfecting effervescent tablet is the same as in example 1, except that the dosage of glycerin is 300g, the dosage of sodium cocoyl glycinate is 1000g, the dosage of lauramidopropyl betaine is 1000g, the dosage of aloe extract is 300g, the dosage of chamomile extract is 200g, the dosage of lysozyme is 300g, the dosage of synergist is 500g, the dosage of sodium bicarbonate is 1500g, the dosage of citric acid is 1500g, the mixing temperature in step S1 is 40 ℃, mixing and stirring are carried out for 20min, the mixing temperature in step S2 is 40 ℃, mixing and stirring are carried out for 20min, the mixing temperature in step S3 is 40 ℃, and mixing and stirring are carried out for 10min; in the step X1, the dosage ratio of the attapulgite to the phosphoric acid aqueous solution is 3g to 50mL, and the concentration of the phosphoric acid aqueous solution is 30wt%; in the step X2, the dosage ratio of 4-chlorobutylamine hydrochloride, phthalimide sodium salt and water is 8g to 1g to 20mL; in the step X3, the dosage ratio of the modifier to the pretreated attapulgite to the N, N-dimethylformamide to the protocatechuic acid to the absolute ethyl alcohol is 15g:8g:150mL:3g:300mL; in the X4 step, the concentration of the dopamine hydrochloride aqueous solution is 30 weight percent, and the dosage ratio of the dopamine hydrochloride aqueous solution to the Tris buffer solution is 4:3, a step of; in the X5 step, the dosage ratio of the modified attapulgite to the absolute ethyl alcohol to the polydopamine is 10g:100mL:2g.
Comparative example 1
A preparation method of a hand washing and disinfecting effervescent tablet comprises the following steps:
s1, placing 200g of glycerol, 800g of sodium cocoyl glycinate and 800g of lauramidopropyl betaine into a mixer, and mixing and stirring for 15min at 25 ℃;
s2, adding 187.5g of aloe extract, 112.5g of chamomile extract, 200g of lysozyme and 400g of attapulgite into a mixer, and continuously stirring for 15min at 25 ℃;
s3, adding 1000g of sodium bicarbonate and 1000g of citric acid into the mixer, and stirring at 25 ℃ for 7.5min to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting at 50 ℃ for 6 hours to obtain the hand-washing disinfection effervescent tablet; the size of the effervescent tablet is 2.6cm multiplied by 1cm.
Comparative example 2
A preparation method of a hand washing and disinfecting effervescent tablet comprises the following steps:
s1, placing 200g of glycerol, 800g of sodium cocoyl glycinate and 800g of lauramidopropyl betaine into a mixer, and mixing and stirring for 15min at 25 ℃;
s2, adding 187.5g of aloe extract, 112.5g of chamomile extract and 200g of lysozyme into a mixer, and continuously stirring for 15min at 25 ℃;
s3, adding 1000g of sodium bicarbonate and 1000g of citric acid into the mixer, and stirring at 25 ℃ for 7.5min to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting at 50 ℃ for 6 hours to obtain the hand-washing disinfection effervescent tablet; the size of the effervescent tablet is 2.6cm multiplied by 1cm.
Test example 1
Detergency test: the test objects are the hand washing and disinfecting effervescent tablets prepared in the examples 1-4 and the comparative examples 1-2, 1 tablet of each hand washing and disinfecting effervescent tablet prepared in the examples 1-4 and the comparative examples 1-2 is taken before testing, and is dissolved by 500mL of water respectively, so that the hand washing and disinfecting liquid is obtained, and the method for measuring the detergency is as follows: respectively taking 10g of the hand washing disinfectant, dropwise adding pure engine oil into the hand washing disinfectant, oscillating, dropwise adding until one drop of engine oil is insoluble, recording the mass of the hand washing disinfectant for dissolving the engine oil, and using the mass of the dissolved engine oil to characterize the detergency of the hand washing disinfectant, wherein the test result is shown in table 1:
table 1 detergency test results table
| Detergency (g) | |
| Example 1 | 3.8 |
| Example 2 | 2.6 |
| Example 3 | 3.6 |
| Example 4 | 3.5 |
| Comparative example 1 | 1.9 |
| Comparative example 2 | 1.4 |
As can be seen from the experimental results in Table 1, the hand washing and disinfecting effervescent tablet prepared in example 1 has the best decontamination performance, while the difference between example 1 and example 2 and comparative examples 1-2 is that polydopamine modified attapulgite is added, and the possible reason for this phenomenon is that on one hand, a modifier prepared from 4-chlorobutylamine hydrochloride and phthalimide sodium salt is inserted into the interlayer of the attapulgite for modification, so that the defect that the attapulgite is easy to agglomerate is avoided, the dispersion of the attapulgite in the system is promoted, the solubility of the attapulgite is improved by grafting protocatechuic acid on the surface, and meanwhile, the functionalized attapulgite can also penetrate into the texture of the skin surface in the kneading process to adsorb dirt, thereby improving the decontamination effect; on the other hand, the modified attapulgite is modified by polydopamine, so that a three-dimensional network structure can be formed on the surface of the skin, the affinity between the attapulgite and the skin is remarkably improved, the adhesion of the skin to the attapulgite is promoted, the utilization rate of the attapulgite is improved, the adsorption of a system to dirt is further improved, and the decontamination effect of the system is further improved.
Test example 2
Antibacterial property measurement: the test objects are hand-washing disinfection effervescent tablets prepared in examples 1-4 and comparative examples 1-2, 1 tablet of the hand-washing disinfection effervescent tablets prepared in examples 1-4 and comparative examples 1-2 is taken before testing, and dissolved with 500mL of water respectively to obtain hand-washing disinfectant, the determination of the antibacterial performance of the hand-washing disinfectant is detected by a method specified by an annex C4 antibacterial performance test method of dissolution antibacterial products in GB/T15979-2002 hygienic standards of disposable hygienic products, wherein the strains to be tested are staphylococcus aureus (ATCC 6538), escherichia coli (ATCC 25922) and candida albicans (ATCC 10231), the detection concentration is 1:100, the action time is 20min, and the test results are shown in Table 2:
table 2 antibacterial property test results table
| Staphylococcus aureus (%) | Coli (%) | Candida albicans (%) | |
| Example 1 | 99.9 | 99.8 | 99.6 |
| Example 2 | 95.3 | 94.7 | 95.4 |
| Example 3 | 99.6 | 99.5 | 99.3 |
| Example 4 | 99.4 | 99.2 | 99.1 |
| Comparative example 1 | 86.1 | 88.4 | 89.5 |
| Comparative example 2 | 75.2 | 73.8 | 69.7 |
From the experimental results in table 2, it can be seen that the hand washing and disinfecting effervescent tablet prepared in example 1 has the best antibacterial performance, probably because the polydopamine modified attapulgite clay has the best affinity with skin and can form a three-dimensional network structure on the surface of skin, the affinity of the attapulgite clay to the skin is remarkably improved, the adhesion of the skin to the attapulgite clay is promoted, and the attapulgite clay is used as a carrier of a bacteriostatic agent and lysozyme, so that the bacteriostatic agent and lysozyme are better dispersed in a system, and the antibacterial effect of the hand washing and disinfecting effervescent tablet is further improved.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (9)
1. The effervescent tablet for washing hands and disinfecting is characterized by comprising the following components in parts by weight: 1-5 parts of plant extract, 1-3 parts of lysozyme, 1-3 parts of humectant, 5-10 parts of sodium cocoyl glycinate, 5-10 parts of lauramidopropyl betaine, 3-5 parts of synergist, 5-15 parts of sodium bicarbonate and 5-15 parts of citric acid.
2. The hand sanitizer effervescent tablet of claim 1, wherein: the mass ratio of the plant extract is 2-3:1-2 and chamomile extract.
3. The hand sanitizer effervescent tablet of claim 1, wherein: the humectant is one or more of glycerol, 1, 3-propylene glycol, lanolin, vaseline and hyaluronic acid.
4. The hand washing and disinfecting effervescent tablet as claimed in claim 1, characterized in that the synergistic agent is modified attapulgite, and the preparation method thereof comprises the following steps:
x1, grinding and sieving attapulgite, and then placing the attapulgite in a phosphoric acid aqueous solution for soaking, washing and roasting to obtain pretreated attapulgite;
x2, mixing 4-chlorobutylamine hydrochloride, phthalimide sodium salt and water for reaction to obtain a modifier;
and X3, mixing the modifier, the pretreated attapulgite and the N, N-dimethylformamide for reaction, filtering after the reaction is finished, collecting a filter cake, washing, and mixing the filter cake, protocatechuic acid and ethanol for reaction to obtain the modified attapulgite.
5. The hand sanitizer effervescent tablet of claim 4, wherein: the dosage ratio of the 4-chlorobutylamine hydrochloride to the phthalimide sodium salt to the water in the step X2 is 3-8g to 1g to 10-20mL.
6. The hand sanitizer effervescent tablet of claim 4, wherein: in the step X3, the dosage ratio of the modifier to the pretreated attapulgite to the N, N-dimethylformamide to the protocatechuic acid to the absolute ethyl alcohol is 5-15 g/3-8 g/50-150 mL/2-3 g/200-300 mL.
7. The hand sanitizer effervescent tablet of claim 4, wherein the modified attapulgite is polydopamine modified attapulgite, and the preparation method comprises the following steps:
preparing dopamine hydrochloride aqueous solution by X4, and adding Tris buffer solution for heating reaction to obtain polydopamine;
x5, adding the modified attapulgite into absolute ethyl alcohol, uniformly stirring, and adding polydopamine
And thermally reacting to obtain the polydopamine modified attapulgite.
8. The hand sanitizer effervescent tablet of claim 7, wherein: in the step X5, the dosage ratio of the modified attapulgite, the absolute ethyl alcohol and the polydopamine is 5-10g:50-100mL:1-2g.
9. A process for preparing a hand sanitizer effervescent tablet as claimed in any one of claims 1 to 8, comprising the steps of:
s1, weighing the components according to a formula, and placing a humectant, sodium cocoyl glycinate and lauramidopropyl betaine into a mixer to be mixed and stirred for 10-20min at 10-40 ℃;
s2, adding the plant extract, the lysozyme and the synergistic agent into a mixer, and continuously stirring for 10-20min at the temperature of 10-40 ℃;
s3, adding sodium bicarbonate and citric acid into the mixer, and stirring for 5-10min at 10-40 ℃ to obtain a mixture;
s4, transferring the mixture into a tablet press for tabletting, and drying the tabletting to obtain the hand-washing disinfection effervescent tablet.
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