CN116473896A - Cosmetic composition using nanoliposomes - Google Patents
Cosmetic composition using nanoliposomes Download PDFInfo
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- CN116473896A CN116473896A CN202210735891.XA CN202210735891A CN116473896A CN 116473896 A CN116473896 A CN 116473896A CN 202210735891 A CN202210735891 A CN 202210735891A CN 116473896 A CN116473896 A CN 116473896A
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- extract
- palm
- cosmetic composition
- nanoliposomes
- medicinal
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Abstract
Cosmetic compositions utilizing nanoliposomes. The present invention relates to cosmetic compositions utilizing nanoliposomes containing peach blossom extracts, lactobacillus fermentation lysates, medicinal dandelion leaf extracts, palm-derived fractions. The present invention provides a cosmetic composition stabilized by nanoliposomes, which comprises 0.1 to 20 wt% nanoliposomes based on the total weight of the cosmetic composition, wherein the nanoliposomes comprise peach blossom extract, lactobacillus fermentation lysate, medicinal dandelion leaf extract and palm-derived fraction extracted by supercritical and ultrasonic extraction as active ingredients. The invention can further improve the effect of improving skin wrinkles, moisturizing and improving skin elasticity.
Description
Technical Field
The present invention relates to a cosmetic composition, and more particularly, to a cosmetic composition using nanoliposomes containing peach blossom extract, lactobacillus fermentation lysate, dandelion extract, palm-derived fraction, wherein the nanoliposomes contain peach blossom extract that maximizes the content of catechin components by supercritical and ultrasonic extraction, and also contain dandelion extract and lactobacillus fermentation lysate, thereby further improving skin wrinkle improving effects and inhibiting skin allergy and inflammation.
Background
Recently, with increasing demands for the functions of cosmetics, functional products having not only cleansing and cosmetic functions as basic functions of cosmetics but also whitening effects of whitening skin, improving and suppressing skin wrinkles, and the like, particularly wrinkle-improving products, are being favored by many women who want to keep youth, and for this reason, attempts to improve skin wrinkles have been continuously made.
The mechanism of skin aging is not a theory to explain. Based on the findings or ongoing findings, it is almost impossible to regenerate skin in which the growth phase is stopped by reconstruction of the skin structure in a vigorous state, but it is found that more positive improvement of the generated wrinkles is still possible, and thus more elastic and smooth skin can be still be dressed.
Typically, active oxygen is a superoxide anion radical (superoxide anion radical) in which oxygen molecules reduce 1 electron, hydrogen peroxide (hydrogen peroxide) in which it reduces again, hydroxyl radical (hydroxyl radical). And, singlet oxygen (singet oxy gen) is generated not by electron movement but by energy movement. The narrow definition of active oxygen is 4 above, but broadly includes their oxidation products, nitrogen peroxide and nitric oxide (nitroshi masaki et al, fargarace j, 19-20 (2000)).
On the other hand, U.S. Pat. No. 5340568 (patent document 1) describes that a composition comprising 2-Deoxy-2-halogenohydrolysophosphatidic acid (2-Deoxy-2-halo-lysophosphatidic acid) having a function similar to that of a growth factor and inducing cell proliferation also inhibits the formation of skin wrinkles, and WO94/04184 shows that a composition for stabilizing a protein growth factor prevents aging phenomena such as skin wrinkles and skin sagging. The protein growth factors used in this description are epidermal growth factor (Epidermal growth factor: EGF), insulin-like growth factor (Insulin-like growth factor: IGF), platelet-derived growth factor (Platelet-derived growth factor: PDGF), fibroblast growth factor (Fibroblast growth factor: FGF), and the like.
However, since some of the above-described skin wrinkle-improving active ingredients cannot be used as cosmetic raw materials or are very unstable and are not easily transferred to the skin, special stabilization systems and transfer systems are required, and the effect of improving skin wrinkles has problems such as being invisible, and recently, a skin protectant containing retinoid has been attracting attention, and retinoid is now used as a means for solving aging phenomena such as wrinkles, thickening of the skin, sagging, and reduction of elasticity as a result of accumulation of sunlight. However, such retinoids are very unstable compounds, are sensitive to light (ultraviolet), moisture, heat, air (oxygen), and have problems of being liable to chemical changes, so there are reported cases of solving these problems.
Substances having a high wrinkle-improving effect such as retinol and retinoic acid have the above problems, and are difficult to use as raw materials for cosmetics due to chemical instability, difficulty in use, complexity of formulation technology, skin irritation, etc., and retinol palmitate or retinol acetate such as retinol acetate Huang Chunzhi and β -carotene, which is a vitamin a precursor, have a low wrinkle-improving effect, but are widely used as raw materials for cosmetics due to ease of use and stability.
Vitamin C is identified as a powerful antioxidant in association with the aging phenomenon of the human body. However, it is difficult to apply the composition to cosmetics due to the stability thereof. In the cosmetic industry, there is a lot of effort to use vitamin C itself, but it is not always possible to overcome the unstable nature, and only various derivatives other than vitamin C itself can be used to reduce the effect. The most important thing related to skin aging is collagen. It is seen from many studies by many researchers that aging is performed and recovered by various complex substances such as collagen and elastin.
The applicant of the present invention has applied for and has been issued "cosmetic compositions using nanoliposomes containing peach flower extracts" (korean patent publication No. 10-2058445, patent document 2) in order to solve the problems occurring in the prior art.
The above patent document 2 maximizes the content of catechin components by supercritical and ultrasonic extraction and includes the content in nanoliposomes, which has excellent moisturizing and elastic effects, whitening effects, and improved stability and transmittance.
On the other hand, a microbiome is a synthesis of a microbiota representing a microbiota and a genome representing a genetic body. In contrast to microbiome, microbiota is a term focused on the microbial strain itself, meaning a microorganism that has a symbiotic relationship with its habitat in the human body, and microbiome refers to studies and techniques of interactions with microbial bonds by genomics-based host organisms that have been separated from existing individual microbiological assays. However, recently, microbiota representing microorganisms are commonly used with microbiota. Microbiome this term is further known as intestinal microbiome, where the potential of lactic acid bacteria to dilate the intestine by ingestion of lactic acid bacteria inhibits harmful bacteria, both of which belong to the microbiome.
Recently, one of the reasons for the focus of microbiota has been from the greatly expanding application functionality associated with human health and disease problems. After the in vivo association of microorganisms with metabolic diseases such as obesity and diabetes, the association with cancers, infections, immunological and mental diseases and the like are found, so that the therapeutic agents based on microbiome are gradually raised as one of innovative therapeutic technologies. The effects of maintaining microbiome balance on human function are well known, and as studies on microbiome and obesity in vivo have been published, there is increasing interest in microbiome studies.
Recently, research on application of such microbiome to skin has been actively conducted, and the related art is made of "cosmetic composition for skin improvement comprising extract of dandelion leaves for medical use" (korean patent publication No. 10-2121006, patent document 3).
After separating lactic acid bacteria from skin, patent document 3 mentioned above prepares a medicinal dandelion leaf extract, cultures the medicinal dandelion leaf extract in microorganisms, dilutes the culture solution, and confirms the increase of probiotics and the decrease of harmful bacteria by counting the colonies of microorganisms.
However, patent document 3 only includes an examination of skin stability, skin oil content, moisture content, and change in microbial distribution.
Prior art literature
Patent literature
Patent document 1: US 5340568 (1994, 08, 23)
Patent document 2: KR 10-2058445 (2019 12, 17)
Patent document 3: KR 10-2121006 (2020, 06, 03)
Disclosure of Invention
The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide a cosmetic composition for further improving skin wrinkle improvement effect and suppressing skin allergy and inflammation by using nanoliposomes containing peach blossom extract and mixing the medicinal dandelion leaf extract, lactobacillus lysate and palm-derived fraction described in patent document 3 in a proper ratio, in accordance with the basic technical idea of patent document 2 filed and granted by the applicant of the present invention.
In order to solve the above problems, the present invention is characterized by comprising 0.1 to 20 weight percent of nanoliposome based on the total weight of the cosmetic, wherein the nanoliposome comprises peach blossom extract, lactobacillus fermentation lysate, dandelion extract and palm-derived fraction extracted by supercritical and ultrasonic extraction method as effective components.
The invention is characterized in that in the composition, the effective components account for 10 to 40 weight percent of the total weight of the nano liposome, and the weight ratio of the peach blossom extract, the lactobacillus fermentation lysate, the medicinal dandelion leaf extract and the palm-derived fractionation is 1:1.5 to 2.5:1 to 2:0.1 to 0.4.
The present invention is characterized in that, in the above constitution, the peach blossom extract and the medicinal dandelion leaf extract are mixed extracts obtained by mixing peach blossom powder and medicinal dandelion leaf powder and extracting by supercritical and ultrasonic extraction.
The present invention is characterized in that in the above constitution, a fermentation liquid obtained by fermenting color-changing jasmine flowers is further added in an amount of 0.4 to 1.2 weight percent to the active ingredient of the nanoliposome.
The invention is characterized in that in the above constitution, the color-changing jasmine flower fermentation liquid is a supernatant obtained by mixing color-changing jasmine flower, salt and vinegar in a weight ratio of 1:2:3, fermenting for 3 months, and separating solid substances.
The present invention provides a cosmetic composition having a skin elasticity improving effect and further improving moisturizing effect and skin wrinkle improving effect.
Detailed Description
In order to achieve the above object, the cosmetic composition comprising peach blossom extract of the present invention is a cosmetic composition stabilized by nanoliposomes, characterized in that it comprises 0.1 to 20 weight percent nanoliposomes comprising peach blossom extract, lactobacillus fermentation lysate, dandelion extract and palm-derived fraction extracted by supercritical and ultrasonic extraction as active ingredients, based on the total weight of the cosmetic.
The invention is characterized in that in the composition, the effective components account for 10 to 40 weight percent of the total weight of the nano liposome, and the weight ratio of the peach blossom extract, the lactobacillus fermentation lysate, the medicinal dandelion leaf extract and the palm-derived fractionation is 1:1.5 to 2.5:1 to 2:0.1 to 0.4.
The present invention is characterized in that, in the above constitution, the peach blossom extract and the medicinal dandelion leaf extract are mixed extracts obtained by mixing peach blossom powder and medicinal dandelion leaf powder and extracting by supercritical and ultrasonic extraction.
The present invention is characterized in that in the above constitution, a fermentation liquid obtained by fermenting color-changing jasmine flowers is further added in an amount of 0.4 to 1.2 weight percent to the active ingredient of the nanoliposome.
The invention is characterized in that in the above constitution, the color-changing jasmine flower fermentation liquid is a supernatant obtained by mixing color-changing jasmine flower, salt and vinegar in a weight ratio of 1:2:3, fermenting for 3 months, and separating solid substances.
The present invention will be described in detail with reference to examples thereof. These examples are merely for more specifically explaining the present invention, and it is obvious to those skilled in the art that the scope of the present invention is not limited to these examples according to the gist of the present invention.
Example 1
First, 1, 3-butanediol (1,3BG,Butylene Glycol) and ethanol were mixed at the same mass ratio and stirred until a single phase was formed, and this was used as a latent solvent in an extraction step using supercritical carbon dioxide.
Drying flos persicae and medicinal herba Taraxaci leaves respectively until no weight change occurs, and pulverizing into size below 0.3cm with pulverizer. Mixing flos persicae and medicinal herba Taraxaci leaf with the latent solvent at a mass ratio of 1:2, stirring for 30 min, and performing ultrasonic extraction at 60deg.C for about 3 hr.
After placing the latent solvent mixture into a supercritical extraction tank having an internal volume of 1.5L and sealing, carbon dioxide was supplied by a high-pressure gas pump to increase the pressure.
Raising the temperature in the extraction tank to 40deg.C at a rate of 0.5 deg.C/min, maintaining for 50 min, discharging the extract while supplying carbon dioxide again, and reducing the pressure to normal pressure to separate carbon dioxide from the extract, discharging carbon dioxide into the atmosphere, and recovering flos persicae extract and medicinal herba Taraxaci leaf extract respectively.
Next, "Lactobacillus plantarum RD-02" was prepared as lactic acid bacteria, and the prepared strain was applied to MRS solid medium, cultured at 37℃for 24 hours, and after culturing the isolated colonies in MRA liquid medium, the colonies were mixed with 20% (v/v) glycerol (glycerol) at a ratio of 1:1 and stored in an ultra-low temperature refrigerator. Then, after the strain is cultured in a medium for fermentation, a sterilizer is used for sterilization, and a filter with the size of 0.1-0.3 μm is used for filtering impurities to obtain lactobacillus fermentation lysate.
Palm-derived fractions were prepared by mixing 4.55 weight percent hydrogenated palm kernel oil, 81.8 weight percent hydrogenated palm kernel hard ester, 4.55 weight percent hydrogenated palm kernel olein, and 4.55 weight percent stearic acid as an adjuvant and 4.55 weight percent ethylene glycol monostearate followed by stirring at 45℃at a stirring speed of 100 rpm.
The thus-prepared palm-derived fraction had a content of caprylic acid (C8) of 0.82% by weight and capric acid (C10) of 7.75% by weight.
Octanoic acid and decanoic acid are known to have potent antibacterial and antiviral properties.
Then, the prepared peach blossom extract, medicinal dandelion leaf extract and lactobacillus fermentation lysate are utilized to prepare the nano liposome.
The nanoliposome was prepared by passing liposome composed of lecithin, palm-derived fraction, glutathione, polysorbate 20, ethanol through a high-pressure emulsifying device 7 times to make its size smaller. First, nano-liposomes of a locked bilayer structure were prepared by high-pressure emulsification of lecithin, palm-derived fractions, glutathione, 95% denatured ethanol, glycerol, polysorbate 20.
The materials of phase a in table 1 were heated to 95 ℃ to be uniformly mixed and dissolved.
After cooling to 40 ℃, phase B material was added to mix.
Then, nanoliposomes were obtained by stabilizing the extract obtained in example 1 and the fermentation lysate by passing through a high-pressure emulsifying device (microfluidizer M210EH, microfluidics Inc., U.S.A.) 7 times under the conditions of a pressure of 1200bar and a flow rate of 500M/s.
The nanoliposome obtained after 1 pass was about 130nm in size, but by 7 th pass, about 71nm in size.
TABLE 1
Next, cosmetic materials containing nanoliposomes were prepared as essences according to a general cosmetic preparation method using the raw materials shown in table 2.
TABLE 2
Example 2
The process was carried out in the same manner as in example 1, and after mixing the peach blossom and the dandelion leaf powder, the extract was prepared by supercritical and ultrasonic extraction in the same manner as in example 1.
Examples 3 to 11
The procedure was carried out in the same manner as in example 1, except that the content of the active ingredient shown in Table 3 was used.
TABLE 3 Table 3
(unit: weight percent)
Examples 12 to 14
Prepared in the same manner as in example 2, except that a color-changing jasmine fermentation broth was added.
Color-changing jasmine (Brunfelcia uniflora) is a evergreen shrub of the Solanaceae family, native to Brazil, beautiful in flowers and pleasant in fragrance, also called Ma Naka or Paraguay jasmine, etc.
The color-changing jasmine contains benzene, terpene, alkaloid, lactone, etc., especially coumarin, alkaloid, lignan, etc.
The color-changing jasmine inhibition has the effects of relieving pain, promoting urination and the like.
There has been no case of using such color-changing jasmine as a raw material for cosmetics.
The color-changing jasmine flower fermentation liquid is supernatant obtained by mixing color-changing jasmine flower, salt and vinegar in the weight ratio of 1:2:3, fermenting for 3 months, and separating solid substances.
The composition of nanoliposome using color-changing jasmine flower fermentation broth is shown in table 4 below.
TABLE 4 Table 4
(unit: weight percent)
Preparation of comparative examples
The liposome content was 2 weight percent in the same manner as in example 1, which was referred to as comparative example 1.
The liposome content was 11 weight percent in the same manner as in example 1, which was referred to as comparative example 2.
The same procedure as in example 1 was conducted except that lactobacillus fermentation lysate and dandelion extract for medicinal use were used, which was designated as comparative example 3.
The same procedure as in example 1 was conducted except that the Lactobacillus fermentum lysate was removed, which was designated as comparative example 4.
The same procedure as in example 1 was conducted except that the fermentation lysate of dandelion leaves for medicinal use was removed, which was designated as comparative example 5.
Experimental examples concerning the above examples and comparative examples will be described below.
Experimental example 1 measurement of skin moisture content
The cosmetic compositions of the above examples and comparative examples were used to measure the skin moisture content.
The chambers in which no air flowed at 22℃to 24℃and a relative humidity of 55% were each divided into 8 groups of 10 women (average age of 29.5 years) were each treated with 80 women. The cosmetics of examples and comparative examples were applied to the entire face centering around the eyes for 6 weeks, respectively, twice a day per group. The moisture content of the cheek parts before and after application was measured by Skicon-200 (IBS Co., ltd., japan) to measure the duration of the moisturizing effect.
The results are shown as the average value of each group in table 4 below.
The improvement degree was calculated according to the following equation 3, and the results are shown in table 5.
Mathematical formula 3
TABLE 5
| Before the test | After 6 weeks of application | Degree of improvement (%) | |
| Example 1 | 630 | 780 | 23.81 |
| Example 2 | 625 | 870 | 39.2 |
| Example 3 | 630 | 890 | 41.27 |
| Example 4 | 628 | 752 | 19.75 |
| Example 5 | 631 | 785 | 24.41 |
| Example 6 | 630 | 690 | 9.52 |
| Example 7 | 626 | 663 | 5.91 |
| Example 8 | 631 | 667 | 5.71 |
| Example 9 | 632 | 672 | 6.33 |
| Example 10 | 629 | 676 | 7.47 |
| Example 11 | 630 | 669 | 6.19 |
| Example 12 | 628 | 721 | 14.81 |
| Example 13 | 631 | 892 | 41.36 |
| Example 14 | 632 | 733 | 15.98 |
| Comparative example 1 | 630 | 635 | 0.79 |
| Comparative example 2 | 632 | 643 | 1.74 |
| Comparative example 3 | 625 | 632 | 1.12 |
| Comparative example 4 | 628 | 641 | 2.07 |
| Comparative example 5 | 632 | 648 | 2.53 |
As shown in the above table, the comparative example shows a very small degree of improvement, but the example shows a superior degree of improvement to the comparative example.
In particular, examples 1 to 5 are significantly more excellent than comparative examples.
Experimental example 2 skin elasticity Effect experiment
The skin elasticity effect was tested in the experimental example. The cosmetic compositions of examples and comparative examples were applied to the entire face around the eyes for 12 weeks (2 times/day) under conditions of 22 to 24 ℃ and a relative humidity of 55% by dividing 60 women over 20 years (average age 29.5 years), and skin elasticity was measured by a skin elasticity tester (Cutometer SEM 575,C+K Electronic Co, germany). In table 5 below, the results are shown as average Δr5 values (R5 (12 weeks) -R5 (0 weeks)) of each test group detected by the skin elasticity detector cupometer SEM 575, and the closer to 1, the more excellent the elasticity is shown as the R5 value is a value showing the actual elasticity coefficient.
The improvement degree was calculated by the following equation 4, and the results are shown in the following table 6.
Mathematics 4
Improvement (%) = (Δr5/before coating) ×100
TABLE 6
Skin elasticity test result (12 weeks)
| Differentiation of | Before coating | After coating | Skin elasticity enhancing effect (DeltaR 5) | Degree of improvement (%) |
| Example 1 | 0.74 | 1.12 | 0.38 | 51.35135 |
| Example 2 | 0.72 | 1.21 | 0.49 | 68.05556 |
| Example 3 | 0.73 | 1.12 | 0.39 | 53.42466 |
| Example 4 | 0.75 | 1.16 | 0.41 | 54.66667 |
| Example 5 | 0.74 | 1.22 | 0.48 | 64.86486 |
| Example 6 | 0.74 | 1.05 | 0.31 | 41.89189 |
| Example 7 | 0.75 | 1.02 | 0.27 | 36 |
| Example 8 | 0.73 | 1.03 | 0.3 | 41.09589 |
| Example 9 | 0.75 | 1 | 0.25 | 33.33333 |
| Example 10 | 0.74 | 1.02 | 0.28 | 37.83784 |
| Example 11 | 0.73 | 1.03 | 0.3 | 41.09589 |
| Example 12 | 0.73 | 1.03 | 0.3 | 41.09 |
| Example 13 | 0.72 | 1.29 | 0.57 | 79.17 |
| Example 14 | 0.75 | 1.02 | 0.27 | 36 |
| Comparative example 1 | 0.74 | 0.79 | 0.05 | 6.756757 |
| Comparative example 2 | 0.72 | 0.76 | 0.04 | 5.555556 |
| Comparative example 3 | 0.75 | 0.77 | 0.02 | 2.666667 |
| Comparative example 4 | 0.74 | 0.78 | 0.04 | 5.405405 |
| Comparative example 5 | 0.74 | 0.81 | 0.07 | 9.459459 |
From the above Table 6, it is clear that the examples are all effective in improving skin elasticity as compared with the comparative example.
Experimental example 3 wrinkle improvement Effect experiment
Experiments on whether or not the cosmetic compositions of examples and comparative examples had immediate wrinkle-improving effects were performed.
For this, 30 women aged 40 to 60 years were used as subjects, and after cleansing, the skin around the eyes was applied once, and the wrinkle depth was measured.
The camera mounted to the wrinkle depth measurement device was focused on the skin around the cleaned eyes and photographed, the value measured by the image analysis software was set to the depth of the initial wrinkles, and after applying the cosmetic water at the set measurement position, the wrinkle reduction rate was measured after 10 minutes.
In this case, the initial wrinkle depth was positioned at "0", the wrinkle depth reduction rate (%) was measured as an evaluation criterion, and the average value of the measurement object was calculated to be shown.
TABLE 7
| Differentiation of | Wrinkle depth reduction Rate (%) |
| Example 1 | 13.5 |
| Example 2 | 14.1 |
| Example 3 | 12.7 |
| Example 4 | 13.2 |
| Example 5 | 13.6 |
| Example 6 | 8.5 |
| Example 7 | 7.7 |
| Example 8 | 8.2 |
| Example 9 | 7.9 |
| Example 10 | 8.0 |
| Example 11 | 7.7 |
| Example 12 | 12.3 |
| Example 13 | 20.1 |
| Example 14 | 13.1 |
| Comparative example 1 | 2.1 |
| Comparative example 2 | 1.6 |
| Comparative example 3 | 0.5 |
| Comparative example 4 | 1.6 |
| Comparative example 5 | 2.1 |
As shown in table 7, it is found that the example has an immediate wrinkle depth improvement effect compared with the comparative example, and the effect of example 13 is more excellent.
Claims (4)
1. A cosmetic composition comprising nanoliposome containing flos persicae extract, lactobacillus fermentation lysate, medicinal herba Taraxaci leaf extract, and palm-derived fraction, characterized in that,
the nano liposome comprises peach blossom extract, lactobacillus fermentation lysate, medicinal dandelion leaf extract and palm source fraction extracted by supercritical and ultrasonic extraction method as effective components, wherein the nano liposome comprises 0.1-20 weight percent of nano liposome relative to the total weight of the cosmetic,
the active ingredients account for 10 to 40 weight percent of the total weight of the nano liposome,
the weight ratio of the peach blossom extract, the lactobacillus fermentation lysate, the medicinal dandelion leaf extract and the palm source fraction is 1:1.5-2.5:1-2:0.1-0.4.
2. The cosmetic composition according to claim 1, wherein the peach flower extract and the dandelion leaf extract are mixed extracts obtained by mixing peach flower powder and dandelion leaf powder and extracting them by supercritical and ultrasonic extraction.
3. The cosmetic composition according to claim 1, wherein the nanoliposome comprises peach blossom extract, lactobacillus fermentation lysate, dandelion leaf extract, palm-derived fraction, and fermentation broth obtained by fermenting color-changing jasmine flower is added to the nanoliposome as an active ingredient in an amount of 0.4 to 1.2 weight percent.
4. The cosmetic composition according to claim 3, wherein the color-changing jasmine flower fermentation liquid is a supernatant obtained by mixing color-changing jasmine flower, salt and vinegar in a weight ratio of 1:2:3, fermenting for 3 months, and separating solid matters.
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| KR20240051475A (en) | 2022-10-13 | 2024-04-22 | 주식회사 휴앤코스메틱 | Cosmetics composition with palm oil fraction |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5340568A (en) | 1992-07-01 | 1994-08-23 | The Procter & Gamble Company | Topical composition and method containing deoxy and halo derivatives of lysophosphatidic acids for regulating skin wrinkles |
| KR100762287B1 (en) * | 2006-02-28 | 2007-10-04 | 주식회사 워터비스 | Cosmetic composition with high amount of minerals comprising deep sea water and extract of peach blossom |
| KR102058445B1 (en) | 2018-11-23 | 2019-12-23 | 주식회사 지웨이코스메틱 | Cosmetics composition with Extract of Sparassis crispa Wulf. ex Fr. |
| KR102065607B1 (en) * | 2019-09-27 | 2020-01-13 | 주식회사 지웨이코스메틱 | cosmetic composition for skin moisturizing and skin elasticity using palm oil fraction |
| KR102121006B1 (en) | 2019-11-11 | 2020-06-09 | 주식회사 래디안 | Cosmetic composition for improvement of skin with Taraxacum officinale |
| KR102270709B1 (en) * | 2021-04-15 | 2021-06-28 | 경호빈 | Cosmetic composition for skin improvement containing complex ceramide and natural extracts |
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