CN116440831A - Industrial production equipment and method for polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use - Google Patents
Industrial production equipment and method for polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use Download PDFInfo
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 178
- 229920000036 polyvinylpyrrolidone Polymers 0.000 title claims abstract description 101
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 title claims abstract description 101
- 239000001267 polyvinylpyrrolidone Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 19
- 230000005180 public health Effects 0.000 title claims abstract description 15
- 238000009776 industrial production Methods 0.000 title claims description 4
- 229910052709 silver Inorganic materials 0.000 claims abstract description 87
- 239000004332 silver Substances 0.000 claims abstract description 87
- 238000004519 manufacturing process Methods 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims description 55
- 238000001556 precipitation Methods 0.000 claims description 49
- 239000002994 raw material Substances 0.000 claims description 35
- 238000003860 storage Methods 0.000 claims description 31
- 238000001514 detection method Methods 0.000 claims description 16
- 230000007306 turnover Effects 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 12
- 239000004973 liquid crystal related substance Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 2
- 239000011810 insulating material Substances 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 230000009471 action Effects 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract description 3
- 150000003951 lactams Chemical group 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 230000005611 electricity Effects 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 11
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- 238000005259 measurement Methods 0.000 description 6
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- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 241000588747 Klebsiella pneumoniae Species 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
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- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
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- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/087—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electric or magnetic energy
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
- B01F35/32—Driving arrangements
- B01F35/32005—Type of drive
- B01F35/3204—Motor driven, i.e. by means of an electric or IC motor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
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Abstract
The invention provides industrialized production equipment and a method for polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use, wherein the equipment comprises: the equipment and the method for forming the polyvinyl pyrrolidone PVP nano silver-carrying material by applying electricity to the polyvinyl pyrrolidone PVP aqueous solution under the intermittent action of ultrasonic waves by using the pure silver electrode to enable the precipitated silver nano particles to be quickly embedded into a cavity formed by PVP molecular hydrocarbon chains and lactam groups can realize industrialized production of the polyvinyl pyrrolidone PVP nano silver-carrying material with wide antibacterial spectrum, high efficiency, stability, no toxicity, no stimulation and no drug resistance, and the whole production process has low energy consumption and no harmful substance emission, overcomes the defects of long production period, low automation level and inapplicability to industrialized production in the prior art, and lays a foundation for the application of the nano silver to the medicine and public health fields.
Description
Technical Field
The invention belongs to the technical field of nano materials, and particularly relates to industrialized production equipment and method for polyvinylpyrrolidone PVP nano silver-loaded materials for medical and public health applications.
Background
"nanosilver" is a short or commonly called "silver nanoparticle" and refers to particles composed of silver atoms, the particle size of which is typically in the range of 1-100 nm. (from Baidu encyclopedia "silver nanoparticles")
In the 21 st century, nano silver has been applied to public health fields, for example, nano silver disinfectant, nano silver antibacterial spray, nano silver antibacterial gel for women and the like have been recorded in 2019-2022 national disinfection product system for nano silver "disinfectant size".
The nano silver has the advantages of ultra-wide antibacterial spectrum, extremely low antibacterial dose (recent research experiments prove that the nano silver can effectively cope with multi-drug resistant bacteria, such as related papers, namely, the antibacterial effect research of nano silver on multi-drug resistant bacteria in the 7 th period of the practical preventive medicine 2020, the inhibition effect of colloid nano silver on Klebsiella pneumoniae producing ultra-wide spectrum beta-lactamase in the 8 th period of the Chinese micro-ecological journal 2020, the inhibition effect of novel nano silver colloid solution in the 2017 rd period on methicillin-resistant staphylococcus aureus in vitro, the inhibition effect of novel nano silver on Klebsiella pneumoniae producing ESS in the 22 nd period of the Chinese new medicine, and the like, but the application of nano silver in medical treatment is still very limited, such as the nano silver product of the Chinese micro-ecological journal 2020, and the nano silver product of the Chinese micro-ecological journal has the nano silver standard 20163140190, the nano silver standard medical dressing of the 20163140177, the nano-grade medical dressing of the Chinese medical standard for medical use, and the like; the main reason for the situation is that the safety and stability of the nano silver are considered, as the silver salt adopted in the prior art is used as a silver source, and a plurality of nano silver materials prepared by a chemical reduction method necessarily contain acid radicals and reactants thereof, so that the biological safety is poor and the nano silver materials cannot be used for quasi-drug products; the method and the equipment are characterized in that a method and a device for producing a nano silver colloid solution with higher concentration and no compound residue by combining a microcomputer-controlled silver electrode-electric steady flow and a membrane separation technology by taking a pure metal silver electrode as a silver source are provided, wherein the pure nano silver is prepared by other physical methods except a chemical method, like production equipment and method of nano silver colloid of China (patent number: 2008100867073); the nano silver colloid prepared by the technology is in a metastable state, nano silver is converged and precipitated, and the biocompatibility is poor, so that the nano silver colloid is difficult to apply to quasi-drug products; the inventor of the invention aims to overcome the problems, and in 2011, the invention of a nano silver antibacterial antiviral combination solution, a preparation method and a product thereof (patent number: 2011103337460) is provided: the nano silver colloid solution produced by the technology of the production equipment and the method of nano silver colloid is added with polyvinylpyrrolidone PVP until the polyvinylpyrrolidone PVP is fully dissolved, and then the mixture is sealed and kept away from light for thirty days at normal temperature, so that the nano silver is autonomously embedded into the molecular structure of the polyvinylpyrrolidone PVP to form the polyvinylpyrrolidone PVP carrying nano silver; the nano silver material improves the biocompatibility of nano silver and solves the coagulation problem of nano silver colloid, a sample is preserved at normal temperature and in a dark place for 10 years practically without nano silver coagulation phenomenon, and the antibacterial effect is as early as possible, and the antibacterial effect is detected by a third party, and the antibacterial rate of the sample for 5 minutes under the nano silver content of 12.5ppm (about twelve parts per million of the weight ratio of nano silver to polyvinylpyrrolidone PVP aqueous solution) is more than 99.9 percent, and particularly the result that the sample is actually nontoxic, nonirritating and metabolizable is obtained by a third party animal experiment under the condition that the nano silver content of the detection sample is improved by ten times; the detection and experiment prove that the polyvinylpyrrolidone PVP loaded nano silver is a nano silver material very suitable for medical and public health applications, but the technology has the defects of long production period, low automation level and inapplicability to industrial production.
Disclosure of Invention
In order to make nano silver widely applied to the fields of medicine and public health, and particularly play a role in resisting drug-resistant bacteria, the invention provides industrialized production equipment and method for polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use, and aims to overcome the defects of long production period, low automation level and inapplicability to industrialized production in the prior art.
Production equipment of polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use: comprises a nano silver precipitation loading device, a raw material storage and supply device, a product collection and storage device and a microcomputer control system, wherein,
the nano silver precipitation loading device comprises a nano silver precipitation loading container 201, a nano silver precipitation loading container cover 202, a pure silver electrode pair group 211, a silver precipitation driving power supply group 208, an ultrasonic transducer group 212, an ultrasonic driving power supply group 215, wiring terminal rows 206 and 213, flat cables 207, 209, 214 and 216 and a stirrer 205, wherein the input end of the silver precipitation driving power supply group 208 is connected with the wiring terminal row 206 through the flat cables 207, the output end of the silver precipitation driving power supply group 208 is connected with the pure silver electrode pair group 211 through the flat cables 209, the pure silver electrode pair group 211 consists of one to more pure silver electrode pairs 210, the pure silver electrode pair group 211 and the stirrer 205 are fixed on the silver precipitation loading container cover 202 and extend downwards into the silver precipitation container 201, the input end of the ultrasonic driving power supply group 215 is connected with the wiring terminal row 213 through the flat cables 214, the output end of the ultrasonic driving power supply group 215 is connected with the ultrasonic transducer group 212, the ultrasonic transducer group 212 consists of one to a plurality of ultrasonic transducers 217, and the ultrasonic transducer group 212 is adhered to the outer side of the bottom of the silver precipitation container 201;
the raw material storage and supply device comprises a raw material storage and supply container 110, a raw material turnover container 103, liquid level sensors 101 and 117, self-sucking pumps 106 and 113, check valves 108 and 115, filters 104 and 111, pipelines 105, 107, 109, 112, 114 and 116, wherein the raw material storage and supply container 110 is in one-way communication with the raw material turnover container 103 through the pipeline 105 of the self-sucking pump 106 and the pipeline 105 of the self-sucking pump 106, when the self-sucking pump 106 works, liquid in the raw material turnover container 103 can be pumped into the raw material storage and supply container 110, the raw material storage and supply container 110 is also in one-way communication with the silver deposit loading container 201 through the pipeline 116 of the self-sucking pump 113 and the pipeline 114 of the self-sucking pump 113, and when the self-sucking pump 113 works, the liquid in the raw material storage container 110 can be pumped into the silver deposit loading container 201;
the product collecting and storing device comprises a product collecting and storing container 307, a product circulating container 314, liquid level sensors 317 and 315, self-sucking pumps 303 and 310, check valves 305 and 312, filters 301 and 308, pipelines 302 and 304, 306 and 309, 311 and 313, wherein the product collecting and storing container 307 is in one-way communication with the silver deposit and loading container 201 through the pipeline 302 and the check valve 305 and the pipeline 304 of the self-sucking pump 303, when the self-sucking pump 303 works, liquid in the silver deposit and loading container 201 can be pumped into the product collecting and storing container 307, the product collecting and storing container 307 is also in communication with the product circulating container 314 through the pipeline 311 and the check valve 312 and the pipeline 313 of the self-sucking pump 310 and the product circulating container 307 of the filter 308, and when the self-sucking pump 310 works, the liquid in the product collecting and storing container 307 can be pumped into the product circulating container 314;
the microcomputer control system is composed of a microcomputer 001, a liquid crystal touch display 002, a detection buffer circuit 003, a drive buffer circuit 004, a first liquid level sensor 101, a second liquid level sensor 117, a third liquid level sensor 203, a fourth liquid level sensor 317, a fifth liquid level sensor 315, a concentration sensor 218, signal lines 102, 118, 204, 318, 316, 219, signal lines 012, 021, 031, 014, wires 041, 042, 044, 045, 047, wiring terminal rows 206, 213, and wiring 046, 043,
the input interface of the microcomputer 001 is connected with the output end of the liquid crystal touch display screen 002 and the output end of the detection buffer circuit 003 respectively through signal lines 021 and 031,
the input end of the detection buffer circuit 003 is connected with the first liquid level sensor 101, the second liquid level sensor 117, the third liquid level sensor 203, the fourth liquid level sensor 317, the fifth liquid level sensor 315 and the concentration sensor 218 through signal lines 102, 118, 204, 318, 316 and 219 respectively,
the output interface of the microcomputer 001 is connected with the input end of the liquid crystal touch display screen 002 and the input end of the driving buffer circuit 004 respectively through signal lines 012 and 014,
the output end of the driving buffer circuit 004 is respectively and sequentially connected with the self-priming pumps 106, 113, 303, 310 and the stirrer 205 through leads 041, 042, 044, 045 and 047,
one end of the wiring terminal block 206 is connected with the output end of the drive buffer circuit 004 through a wiring 046, the other end is connected with the input end of the silver precipitation drive power supply group 208 through a wiring 207,
one end of the connection terminal block 213 is connected to the output end of the drive buffer circuit 004 through a flat cable 043, and the other end is connected to the input end of the ultrasonic drive power supply unit 215 through a flat cable 214.
A method for producing polyvinyl pyrrolidone PVP carrying nano silver for medical and public health uses comprises the following steps: by using the equipment, under the control of a microcomputer control system, the polyvinylpyrrolidone PVP aqueous solution in a raw material storage and supply container is pumped into a nano silver precipitation and loading container, stirring is started, and the pure silver electrode pair immersed in the polyvinylpyrrolidone PVP aqueous solution is electrified, so that silver precipitation occurs on the surface of the pure silver electrode pair and silver nano particles are formed in the polyvinylpyrrolidone PVP aqueous solution, then ultrasonic waves are applied to the solution, due to the action of the ultrasonic waves, the collision probability of polyvinylpyrrolidone PVP molecules and the silver nano particles is increased, the silver nano particles are quickly embedded into a cavity formed by a polyvinylpyrrolidone PVP molecular hydrocarbon chain and a lactam group, so as to form polyvinylpyrrolidone PVP nano silver, meanwhile, the microcomputer control system monitors the concentration of the polyvinylpyrrolidone nano silver loaded in the polyvinylpyrrolidone precipitation container in real time through a concentration sensor, repeatedly executes the work of ' pure silver electrode pair and ' applying ultrasonic waves ' until the concentration sensor reaches a set value, namely, the microcomputer control system stops the concentration sensor is controlled to control the concentration of the pure silver electrode pair to be added into the polyvinylpyrrolidone PVP aqueous solution until the concentration sensor reaches the set value, and the PVP is repeatedly loaded into the PVP solution container after the PVP has reached the set value.
By adopting the technical scheme, the invention can achieve the following beneficial effects:
the production efficiency of the polyvinylpyrrolidone PVP loaded nano silver for medical and public health uses is obviously improved, and the method is suitable for realizing industrialized production.
The invention is described in further detail below with reference to the attached drawings and detailed description:
drawings
FIG. 1 is a diagram of a microcomputer control system of a preferred embodiment of the present invention;
FIG. 2 is a system diagram of a production facility in accordance with a preferred embodiment of the present invention;
FIG. 3 is a flowchart of a main program of a microcomputer according to a preferred embodiment of the present invention;
reference numerals illustrate:
105. 107, 109, 112, 114, 116, 302, 304, 306, 309, 311, 313 are pipelines, 104, 111, 301, 308 are filters, 108, 115, 305, 312 are check valves, 106, 113, 303, 310 are self-priming pumps, 101, 117, 203, 317, 315 are level sensors, 218 are concentration sensors, 205 are stirrers, 102, 118, 204, 219, 318, 316 and 012, 021, 031, 014 are signal lines, 206, 213 are wiring terminal rows, 207, 209, 216, 214 are flat cables, 208 are silver precipitation driving power supply groups, 210 are pure silver electrode pairs, 211 are pure silver electrode pair groups, 215 are ultrasonic driving power supply groups, 217 are ultrasonic transducers, 212 are ultrasonic transducers groups, 201 are silver precipitation loading containers, 202 are silver precipitation loading container covers, 110 are raw material storage and supply containers, 307 are product collection and storage containers, 103 are raw material containers, and 314 are product turnover containers; 001 is a microcomputer, 002 is a liquid crystal touch display screen, 003 is a detection buffer circuit and 004 is a drive buffer circuit;
t1 is the time or the time for powering up the pure silver electrode pair (the device is controlled by a microcomputer to execute the work for powering up the pure silver electrode pair in the time period T1), T3 is the time or the time for loading ultrasonic waves (the device is controlled by the microcomputer to execute the work for applying ultrasonic waves to the liquid in the nano silver precipitation loading container in the time period T3),t2 is from the working stop of the T1 time period to the working stop of the T3 time periodThe duration or time of the start interval; d is a product set concentration value.
Description of the embodiments
Referring to fig. 1 and 2: the production equipment of the polyvinylpyrrolidone PVP loaded with nano silver for medical and public health uses comprises: nanometer silver separates out loading means, raw materials storage feeding device, product collection storage device, computer control system, wherein:
the nano silver precipitation loading device comprises a nano silver precipitation loading container 201 (volume 100L), a nano silver precipitation loading container cover 202, a pure silver electrode pair group 211, a silver precipitation driving power supply group 208, an ultrasonic transducer group 212, an ultrasonic driving power supply group 215, wiring terminal rows 206 and 213, flat wires 207 and 209, 214 and 216 and a stirrer 205, wherein the input end of the silver precipitation driving power supply group 208 is connected with the wiring terminal row 206 through the flat wires 207, the output end of the silver precipitation driving power supply group 208 is connected with the pure silver electrode pair group 211 through the flat wires 209, the pure silver electrode pair group 211 consists of twelve pairs of pure silver electrodes 210 (the pure silver electrode pair 210 consists of two metal silver electrodes with the purity of 99.99 percent), and the pure silver electrode pair group 211 and the stirrer 205 are fixed on the silver precipitation loading container cover 202 and extend downwards into the silver precipitation container 201; the input end of the ultrasonic driving power supply group 215 is connected with the wiring terminal block 213 through a flat cable 214, the output end of the ultrasonic driving power supply group 215 is connected with the ultrasonic transducer group 212 through a flat cable 216, the ultrasonic transducer group 212 consists of twelve ultrasonic transducers 217, and the ultrasonic transducer group 212 is adhered to the outer side of the bottom of the silver precipitation loading container 201;
the raw material storage and supply device comprises a raw material storage and supply container 110 (volume 1000L), a raw material turnover container 103, liquid level sensors 101 and 117, self-sucking pumps 106 and 113, check valves 108 and 115, filters 104 and 111, pipelines 105 and 107, 109, 112 and 114 and 116, wherein the raw material storage and supply container 110 is in one-way communication with the raw material turnover container 103 through the pipeline 105 of the self-sucking pump 106 and the filter 104 of the pipeline 107 of the self-sucking pump 106, when the self-sucking pump 106 works, liquid in the raw material turnover container 103 can be pumped into the raw material storage and supply container 110, the raw material storage and supply container 110 is also in one-way communication with a silver deposit loading container 201 through the pipeline 115 of the pipeline 112 of the self-sucking pump 113 and the pipeline 116 of the pipeline 114 of the self-sucking pump 113, and when the self-sucking pump 113 works, the liquid in the raw material storage container 110 can be pumped into the silver deposit container 201;
the product collecting and storing device comprises a product collecting and storing container 307 (volume 1000L), a product turnover container 314, liquid level sensors 315 and 317, self-sucking pumps 303 and 310, one-way valves 305 and 312, filters 301 and 308, pipelines 302 and 304, 306 and 309, 311 and 313, wherein the product collecting and storing container 307 is in one-way communication with the silver precipitation loading container 201 through the pipeline 302 and the one-way valve 305, the pipeline 302 and the self-sucking pump 303, the filter 301 and the silver precipitation loading container 201 are in one-way communication, and when the self-sucking pump 303 works, liquid in the silver precipitation loading container 201 can be pumped into the product collecting and storing container 307; the product collecting and storing container 307 is also communicated with the product turnover container 314 through a pipeline 309, a pipeline 311 of the self-priming pump 310 and a pipeline 313 of a one-way valve 312, and when the self-priming pump 310 works, liquid in the product collecting and storing container 307 can be pumped into the product turnover container 314;
the microcomputer control system is composed of a microcomputer 001 (Raspberry Pi), a liquid crystal touch display 002, a detection buffer circuit 003, a drive buffer circuit 004, a first liquid level sensor 101, a second liquid level sensor 117, a third liquid level sensor 203, a fourth liquid level sensor 317, a fifth liquid level sensor 315, a concentration sensor 218, signal lines 102, 118, 204, 318, 316, 219, signal lines 012, 021, 031, 014, wires 041, 042, 044, 045, 047, terminal blocks 206, 213, and bus lines 046, 043,
the input interface of the microcomputer 001 is connected with the output end of the liquid crystal touch display screen 002 and the output end of the detection buffer circuit 003 respectively through signal lines 021 and 031,
the input end of the detection buffer circuit 003 is connected with the first liquid level sensor 101, the second liquid level sensor 117, the third liquid level sensor 203, the fourth liquid level sensor 317, the fifth liquid level sensor 315 and the concentration sensor 218 in sequence through signal lines 102, 118, 204, 318, 316 and 219 respectively, wherein the first liquid level sensor 101 and the fifth liquid level sensor 315 are non-contact liquid level sensors, and the second liquid level sensor 117, the third liquid level sensor 203 and the fourth liquid level sensor 317 are double-floating ball liquid level sensors;
the output interface of the microcomputer 001 is connected with the input end of the liquid crystal touch display screen 002 and the input end of the driving buffer circuit 004 respectively through signal lines 012 and 014,
the output end of the driving buffer circuit 004 is respectively and sequentially connected with the self-priming pumps 106, 113, 303, 310 and the stirrer 205 through leads 041, 042, 044, 045 and 047,
one end of the wiring terminal block 206 is connected with the output end of the drive buffer circuit 004 through a wiring 046, the other end is connected with the input end of the silver precipitation drive power supply group 208 through a wiring 207,
one end of the connection terminal block 213 is connected to the output end of the drive buffer circuit 004 through a flat cable 043, and the other end is connected to the input end of the ultrasonic drive power supply unit 215 through a flat cable 214.
Method for producing polyvinyl pyrrolidone PVP-loaded nanosilver for medical and public health use using the above preferred embodiment apparatus: pumping polyvinylpyrrolidone PVP aqueous solution in a raw material storage and supply container into a nano silver precipitation and loading container under the control of a microcomputer control system of the equipment, starting stirring and powering on a pure silver electrode pair immersed in the polyvinylpyrrolidone PVP aqueous solution for a period of time T1 (for example, 5 minutes), and then applying ultrasonic waves to the polyvinylpyrrolidone PVP aqueous solution for a period of time T3 (for example, 2 minutes) after a period of time T2 (for example, 10 seconds); silver is separated out from the surface of the silver electrode in the T1 time period, silver nano particles are formed under the action of water molecules by the silver separated out in the T2 time period, molecular movement in the PVP water solution is aggravated due to the action of ultrasonic waves in the T3 time period, so that the collision probability of PVP molecules and the silver nano particles is greatly increased, and the silver nano particles are quickly embedded into a cavity formed by hydrocarbon chains of PVP molecules and lactam groups to form PVP-loaded nano silver; after the time T3 is finished, the microcomputer control system can detect whether the concentration of the nano silver carried by the polyvinylpyrrolidone PVP in the nano silver precipitation and loading container reaches a set value D through a concentration sensor according to program setting, and if the concentration does not reach the set value D, the work of T1, T2 and T3 is circularly executed; if the concentration reaches the set value D, the polyvinylpyrrolidone PVP loaded nano silver product in which nano silver is precipitated and loaded in the container is pumped into the product collecting and storing container, and then the equipment repeats the above work under the control of the microcomputer.
The flow of the microcomputer main program of the above apparatus and method is as shown in fig. 3:
the main detection and experimental results of the polyvinylpyrrolidone PVP-loaded nano silver samples produced by the application examples of the equipment and the method are shown in the following tables 1, 2 and 3:
table 1:
| project | Method | Results |
| Toxicology examination of sample with nano silver concentration of 25ppm | J.of health (2002 edition) 2.3.1, 2.3.3.3.2, 2.3.5 Strip | Is practically nontoxic and has no stimulation to damaged skin and mucous membrane |
| Sample with concentration of 12.5ppm of carried nano silver for colibacillus and golden yellow Staphylococcus, candida albicans and 5-minute sterilization experiment | Ministry of health, sterilizing technical Specification (2002 edition) 2.1.11.3.1 | The sterilization rate is 99.98 percent |
Table 2:
| project | Metabolism experiment of mice by oral lavage with 180ppm sample carrying nano silver concentration |
| Method | (1) Experimental animals: balb/C mice, weight 23-25 g, divided into A, B, C groups, A group as blank control group, B group and C group as administration group, each group of 12The male and the female are half, and the male and the female are fed in separate cages; (2) experiment Medicament: polyvinylpyrrolidone PVP carrying nano silver solution with silver content of 180 ppm. (3) The administration mode is as follows: group B and group C mice were orally administered by gastric lavage once daily with each mouse administered in the amount of 0.25ml of silver was daily ingested in total amounts of 0.045ug per mouse. Group B and group C stop simultaneously after continuous administration for 15 days, wherein the group B is obtained by detecting liver and kidney, recording data and comparing the data with the related data of group A, and the group C stops And (5) feeding the medicine for another 15 days in a normal mode, and taking liver and kidney detection, recording data and A, B group related data for comparison. |
| Liver tissue test data (ppb) | Group A: 0.03, 4.33,1.40; group B: 28.86 117.59, 115.58; group C: 2.59 21.41, 10.47; |
| renal tissue test data (ppb) | Group A: 1.16, 19.95, 6.05; group B: 7.64, 37.58, 67.12; group C: 3.04, 6.80, 7.36; |
| results | The liver and kidney cell tissue morphology at each stage is normal through electron microscope observation and analysis; the silver content in the liver and kidney decreased significantly after 2 weeks of drug withdrawal. |
Table 3:
| project | Method | Results |
| Concentration of carried nano silver 100ppm sample to mice Oral gastric lavage metabolism experiment | (1) Experimental animals: balb/c mice (20-22 g) 24, randomly divided into 3 groups, 1 group is 2% PVP water solution control group, group 2 is PVP carried nano silver experiment 2 weeks group (oral gastric lavage 2 weeks stopping drug, and each detection is carried out after stopping drug), group 3 is PVP carries nano silver to prolong the metabolome (oral gastric lavage is carried out for 2 weeks, and various detection is carried out after 2 weeks of drug withdrawal); (2) experiment Medicament: polyvinyl pyrrolidone PVP carrying nano silver solution with silver content of 100 ppm; (3)the administration mode is as follows: oral administration of mice The administration was by gastric lavage, once daily, with each mouse administered at 0.3ml. Mouse serum silver assay (ICP- MS): first measurement: group 1 (2% pvp control) specimen number: 1-2,1-3,1-4; measurement results (ppb): 0.58, 0.49 2.02; group 2 (PVP nanosilver loaded experiment 2 weeks: measured 2 weeks after dosing) with a mark number of 2-1, 2-2,2- 4, a step of; measurement results (ppb): 30.30 30.66, 19.30; second measurement: group 1 (2% pvp control), sample number: 10 13, 14; measurement results (ppb): 2.26,2.28,1.26; group 3 (PVP nano silver loaded experiment extended metabolome: stop) Measured after 2 weeks of administration) label number: 34 35, 36; measurement results (ppb): 4.03 1.78, 6.30; | serum after 2 weeks of drug withdrawal The silver content in the alloy is obvious Descending. |
Claims (5)
1. An industrial production device for polyvinyl pyrrolidone PVP carrying nano silver for medical and public health use, which is characterized in that: the equipment comprises a nano silver precipitation loading device, a raw material storage and supply device, a product collection and storage device and a microcomputer control system, wherein,
the nano silver precipitation loading device is composed of a nano silver precipitation loading container (201), a nano silver precipitation loading container cover (202), a pure silver electrode pair group (211), an ultrasonic wave driving power supply group (208), a connecting terminal row (206) (213) (207) (209) (214) (216) and a stirrer (205), wherein the nano silver precipitation loading container cover (202) is composed of a pure silver electrode pair group (211), an ultrasonic wave driving power supply group (215) and a connecting terminal row (207) (216), the input end of the silver precipitation driving power supply group (208) is connected with the connecting terminal row (206) through the connecting wire (207), the output end of the silver precipitation driving power supply group (208) is connected with the pure silver electrode pair group (211) through the connecting wire (209), the pure silver electrode pair group (211) is composed of one to a plurality of pure silver electrode pairs (210), the pure silver electrode pair group (211) and the stirrer (205) are fixed on the silver precipitation loading container cover (202) and extend downwards into the silver precipitation container (201), the input end of the ultrasonic wave driving power supply group (215) is connected with the connecting terminal row (213) through the connecting wire (214), the output end of the ultrasonic wave driving power supply group (215) is connected with the ultrasonic wave transducer (212) through the connecting wire pair (212), the ultrasonic transducer group (212) is adhered to the outer side of the bottom of the silver precipitation container (201);
the raw material storage and supply device comprises a raw material storage and supply container (110), a liquid level sensor (101) (117) of the raw material circulation container (103), a self-priming pump (106) (113) check valve (108) (115), a filter (104) (111), pipelines (105) (107) (109) (112) (114) (116), the raw material storage and supply container (110) is in one-way communication with the raw material circulation container (103) through the self-priming pump (106) pipeline (104) of the pipeline (108) check valve (107), when the self-priming pump (106) works, liquid in the raw material circulation container (103) can be pumped into the raw material storage and supply container (110), the raw material storage and supply container (110) is also in one-way communication with the silver precipitation container (201) through the filter (111) pipeline (112) self-priming pump (113) pipeline (114) check valve (115), and the liquid in the raw material storage container (110) can be pumped into the silver precipitation container (201) when the self-priming pump (113) works;
the product collecting and storing device is composed of a self-priming pump (303) (310) check valve (305) (312) filter (301) (308) pipeline (302) (304) (309) (313) comprising a product collecting and storing container (307) and a product turnover container (314), a liquid level sensor (317) (315) and a self-priming pump (303) (312) filter (301) (304) (309) (313) are arranged in the product collecting and storing container (307), the product collecting and storing container (307) is in one-way communication with the silver precipitation and loading container (201) through the self-priming pump (303) pipeline (304) filter (301) and the self-priming pump (302), when the self-priming pump (303) works, liquid in the silver precipitation and loading container (201) can be pumped into the product collecting and storing container (307), the product collecting and storing container (307) is also in one-way communication with the product turnover container (314) through the filter (308) pipeline (309) and the self-priming pump (310) pipeline (311) check valve (313) and the product turnover container (314);
the microcomputer control system is composed of a signal line (102) (118) (204) (318) (316) (219) and a signal line (012) (021) (031) (014) lead (041) (042) (044) (045) (047) wiring terminal row (206) (213) wiring (046) (043) including a microcomputer (001) liquid crystal touch display screen (002) detection buffer circuit (003) driving buffer circuit (004) a first liquid level sensor (101) a second liquid level sensor (117), a third liquid level sensor (203), a fourth liquid level sensor (317), a fifth liquid level sensor (315) a concentration sensor (218) signal line (102) (204) (318) (316) (219) and a signal line (012) (021) (014) (044) (046) (043),
an input interface of the microcomputer (001) is respectively connected with an output end of the liquid crystal touch display screen (002) and an output end of the detection buffer circuit (003) in sequence through signal lines (021) (031), an input end of the detection buffer circuit (003) is respectively connected with a concentration sensor (218) of a fifth liquid level sensor (315) of a third liquid level sensor (203) of a fourth liquid level sensor (317) of a third liquid level sensor (117) of a first liquid level sensor (101) in sequence through signal lines (102) (118) (204) (318) (316) (219),
the output interface of the microcomputer (001) is respectively connected with the input end of the liquid crystal touch display screen (002) and the input end of the driving buffer circuit (004) in sequence through signal lines (012) (014),
the output end of the driving buffer circuit (004) is respectively and sequentially connected with the stirrer (205) of the self-priming pump (106) (113) (303) (310) through leads (041) (042) (044) (045) (047),
one end of the wiring terminal row (206) is connected with the output end of the drive buffer circuit (004) through a flat cable (046), the other end is connected with the input end of the silver precipitation drive power supply unit (208) through a flat cable (207),
one end of the wiring terminal strip (213) is connected with the output end of the driving buffer circuit (004) through a flat cable (043), and the other end is connected with the input end of the ultrasonic driving power supply unit (215) through a flat cable (214).
2. The production facility of claim 1, wherein: the pure silver electrode pair (210) is composed of two metallic silver electrodes with purity of 99.99%.
3. The production facility of claim 1, wherein: the silver deposit loading container cover (202) of claim 1, made of an insulating material.
4. A method for producing polyvinylpyrrolidone PVP-loaded nano silver by using the device of any one of claims 1 to 3, which is characterized in that: under the control of the microcomputer control system of the equipment, pumping polyvinylpyrrolidone PVP aqueous solution in a raw material storage supply container into a nano silver precipitation loading container, starting stirring and electrifying a pure silver electrode pair immersed in the polyvinylpyrrolidone PVP aqueous solution, then repeatedly executing the work of 'pure silver electrode pair electrifying' and 'applying ultrasonic wave' until the concentration value does not reach a set value, and controlling the microcomputer control system to stop 'pure silver electrode pair electrifying' and 'applying ultrasonic wave' until the concentration value reaches the set value, namely, stopping the work of 'pure silver electrode pair electrifying' and 'applying ultrasonic wave' until the concentration value reaches the set value, so that the polyvinylpyrrolidone PVP aqueous solution is repeatedly loaded into the polyvinylpyrrolidone storage container, and finally, the microcomputer control system loads the PVP aqueous solution into the nano silver storage container.
5. The method according to claim 4, wherein: the polyvinylpyrrolidone PVP aqueous solution for producing the polyvinylpyrrolidone PVP carrying nano silver for medical use is prepared from medical polyvinylpyrrolidone PVP and medical purified water.
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| CN116966115B (en) * | 2023-08-24 | 2024-02-20 | 佛山市思怡诺生物科技有限公司 | Long-acting antibacterial pet cleaning care agent and preparation method thereof |
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