CN116421774A - Targeted wound biomass repairing dressing and preparation process thereof - Google Patents
Targeted wound biomass repairing dressing and preparation process thereof Download PDFInfo
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- CN116421774A CN116421774A CN202310422349.3A CN202310422349A CN116421774A CN 116421774 A CN116421774 A CN 116421774A CN 202310422349 A CN202310422349 A CN 202310422349A CN 116421774 A CN116421774 A CN 116421774A
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- 239000002028 Biomass Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 38
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 36
- 230000008439 repair process Effects 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000126 substance Substances 0.000 claims abstract description 28
- 229920000642 polymer Polymers 0.000 claims abstract description 25
- 230000008719 thickening Effects 0.000 claims abstract description 25
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 24
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000011575 calcium Substances 0.000 claims abstract description 20
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 20
- 239000004519 grease Substances 0.000 claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 16
- 239000004014 plasticizer Substances 0.000 claims abstract description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 12
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 12
- 239000000741 silica gel Substances 0.000 claims abstract description 12
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 77
- 238000003756 stirring Methods 0.000 claims description 60
- 239000000499 gel Substances 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 18
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 18
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 18
- 239000011259 mixed solution Substances 0.000 claims description 16
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 9
- 241001424341 Tara spinosa Species 0.000 claims description 9
- 229930003427 Vitamin E Natural products 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical group O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 9
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 9
- 125000005456 glyceride group Chemical group 0.000 claims description 9
- 230000002175 menstrual effect Effects 0.000 claims description 9
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 9
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 9
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 9
- 229960002216 methylparaben Drugs 0.000 claims description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 9
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 9
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 9
- 229960003415 propylparaben Drugs 0.000 claims description 9
- 229940083037 simethicone Drugs 0.000 claims description 9
- 235000010413 sodium alginate Nutrition 0.000 claims description 9
- 239000000661 sodium alginate Substances 0.000 claims description 9
- 229940005550 sodium alginate Drugs 0.000 claims description 9
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 9
- 235000010234 sodium benzoate Nutrition 0.000 claims description 9
- 239000004299 sodium benzoate Substances 0.000 claims description 9
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 229940046009 vitamin E Drugs 0.000 claims description 9
- 235000019165 vitamin E Nutrition 0.000 claims description 9
- 239000011709 vitamin E Substances 0.000 claims description 9
- 235000010493 xanthan gum Nutrition 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- 229940082509 xanthan gum Drugs 0.000 claims description 9
- 239000003242 anti bacterial agent Substances 0.000 claims description 8
- 159000000007 calcium salts Chemical class 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 239000012266 salt solution Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 239000000022 bacteriostatic agent Substances 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 36
- 208000027418 Wounds and injury Diseases 0.000 abstract description 36
- 230000006870 function Effects 0.000 abstract description 13
- 230000029663 wound healing Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 abstract description 3
- 230000003467 diminishing effect Effects 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 102000008186 Collagen Human genes 0.000 abstract description 2
- 108010035532 Collagen Proteins 0.000 abstract description 2
- 229920001436 collagen Polymers 0.000 abstract description 2
- 210000002950 fibroblast Anatomy 0.000 abstract description 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229920002643 polyglutamic acid Polymers 0.000 description 12
- 206010070834 Sensitisation Diseases 0.000 description 11
- 230000008313 sensitization Effects 0.000 description 11
- 230000007794 irritation Effects 0.000 description 10
- 206010048038 Wound infection Diseases 0.000 description 8
- 230000007059 acute toxicity Effects 0.000 description 7
- 231100000403 acute toxicity Toxicity 0.000 description 7
- 230000008952 bacterial invasion Effects 0.000 description 7
- 231100001083 no cytotoxicity Toxicity 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a targeted wound biomass repairing dressing and a preparation process thereof, and particularly relates to the technical field of biomedical materials, wherein the targeted wound biomass repairing dressing comprises the following raw materials in parts by weight: 30-40 parts of chitosan, 15-30 parts of calcium polyglutamate, 5-15 parts of hyaluronic acid, 8-20 parts of silica gel, 40-60 parts of high polymer thickening material, 1-5 parts of plasticizer, 3-7 parts of bacteriostat, 1-3 parts of surfactant, 10-20 parts of grease substance and 80-120 parts of water. The biomass repair dressing for the targeted wound and the preparation process thereof have excellent biocompatibility, and the added chitosan enables the product to have the functions of resisting bacteria, sterilizing, diminishing inflammation and the like, so that the bacterial infection probability in the wound healing process is remarkably reduced, the content of the chitosan is controllable, the growth of fibroblasts can be remarkably inhibited, the generation of collagen of the cells is promoted, and the self repair of the targeted wound is ensured.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a targeted wound biomass repairing dressing and a preparation process thereof.
Background
Because pathogens such as staphylococcus aureus, escherichia coli and the like multiply on the wound, wound infection is easy to cause; the infected wound is not easy to heal, body fluid loss is easy to cause various complications, along with the high-speed development of modern science and technology, the research of medical dressing is rapidly developed, various novel medical dressing is continuously developed, the performance is also more and more excellent, the indexes such as skin irritation, cytotoxicity and sensitization characteristics of the preparation are all in accordance with application requirements, in the preparation of gel or paste preparation containing oil substances, a surfactant is often required to be added to play a role of solubilization or emulsification, so that the oil substances stably exist in a preparation system, but excessive surfactant can increase the irritation, sensitization and cytotoxicity of products, and further the application of the oil gel preparation is restricted to a certain extent.
The Chinese patent document CN114917184B discloses a viscous medical dressing and a preparation process thereof, wherein the raw materials comprise 18-35% of polymer thickening material, 3-18% of plasticizer, 0.1-3% of effective substance, 0.05-0.2% of bacteriostat, 0.025-0.5% of surfactant, 2-10% of grease substance and the balance of water, and the preparation steps are as follows: s1, dispersing and homogenizing a polymer thickening material with water, heating and stirring to obtain a material A, and circulating the material A; s2, mixing the grease substances, heating and preserving heat for later use; s3, adding a plasticizer, a bacteriostat and a surfactant into the circulated material A for circulation, and stirring and mixing to obtain a material B; s4, adding oil substances into the material B, homogenizing, stirring, cooling, and adding the effective substances dissolved by water; s5, circulating, stirring and cooling to obtain the product;
in daily use, the patent can be made into a sticky medical dressing, but only has the functions of controlling exudates of a wound, protecting the wound from being polluted by bacteria, dust particles and other external sources, and basically stopping bleeding, has no antibacterial, sterilizing, anti-inflammatory and other functions on the wound, cannot keep the wound moist, delays wound healing, and easily damages new tissues when changing the dressing.
Disclosure of Invention
The invention mainly aims to provide a targeted wound biomass repair dressing and a preparation process thereof, which can effectively solve the problems of delayed wound healing and easy damage to new wound tissues during dressing change.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a targeted wound biomass repairing dressing and a preparation process thereof comprise the following raw materials in parts by weight: 30-40 parts of chitosan, 15-30 parts of calcium polyglutamate, 5-15 parts of hyaluronic acid, 8-20 parts of silica gel, 40-60 parts of high polymer thickening material, 1-5 parts of plasticizer, 3-7 parts of bacteriostat, 1-3 parts of surfactant, 10-20 parts of grease substance and 80-120 parts of water.
Preferably, the polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
Preferably, the grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
Preferably, the bacteriostat comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate and the like.
Preferably, the calcium polyglutamate is prepared by dissolving polyglutamate in deionized water, stirring to fully dissolve and mix the polyglutamate, slowly adding a calcium salt solution, and chelating for 3 hours at 65 ℃.
The invention also discloses a preparation process of the wound-targeting biomass repair dressing, which comprises the following preparation steps:
s1, dispersing a polymer thickening material with water, putting the polymer thickening material into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding a plasticizer, a bacteriostat and a surfactant into the mixture A after cyclic heating, and stirring and mixing to obtain a mixture B;
s3, adding oil and fat substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring chitosan, calcium polyglutamate and hyaluronic acid into water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into the silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in the menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Compared with the prior art, the invention has the following beneficial effects:
1. the prepared biomass repairing dressing has excellent biocompatibility and wound repairing function, and the chitosan is added to enable the product to have the functions of resisting bacteria, sterilizing, diminishing inflammation and the like, reduce the infection probability in the wound healing process, and simultaneously have the function of quickly stopping bleeding, and the content of the chitosan is controllable, so that the growth of fibroblasts can be obviously inhibited, the generation of collagen of the cells is promoted, and the self-repairing of the targeted wound is ensured.
2. The biomass repairing dressing plays a role in resisting bacterial invasion by being applied to the surface of a wound, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, can not adhere to the wound, reduces secondary damage caused by dressing replacement, reduces the workload of staff, and has good medical application prospect.
Detailed Description
The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
Example 1
The embodiment discloses a targeted wound biomass repair dressing, which comprises the following raw materials in parts by weight: 30-40 parts of chitosan, 15-30 parts of calcium polyglutamate, 5-15 parts of hyaluronic acid, 8-20 parts of silica gel, 40-60 parts of high polymer thickening material, 1-5 parts of plasticizer, 3-7 parts of bacteriostat, 1-3 parts of surfactant, 10-20 parts of grease substance and 80-120 parts of water.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
Example two
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 40 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 3 parts of bacteriostat and 1 part of surfactant into the mixture A after cyclic heating, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding oil and fat substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 30 parts of chitosan, 15 parts of calcium polyglutamate, 1 part of plasticizer and 5 parts of hyaluronic acid into 80 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into 8 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Example III
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 44 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 4 parts of bacteriostat and 1 part of surfactant into the mixture A after cyclic heating, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding 12 parts of grease substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 32 parts of chitosan, 18 parts of calcium polyglutamate, 2 parts of plasticizer and 11 parts of hyaluronic acid into 88 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into 7 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Example IV
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 48 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 5 parts of bacteriostat and 2 parts of surfactant into the mixture A after cyclic heating, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding 14 parts of grease substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 34 parts of chitosan, 21 parts of calcium polyglutamate, 3 parts of plasticizer and 14 parts of hyaluronic acid into 96 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into 9 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Example five
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 52 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 5 parts of bacteriostat and 2 parts of surfactant into the mixture A after cyclic heating, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding 16 parts of grease substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 36 parts of chitosan, 24 parts of calcium polyglutamate, 3 parts of plasticizer and 16 parts of hyaluronic acid into 102 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into 11 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Example six
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 56 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 6 parts of bacteriostat and 3 parts of surfactant into the mixture A which is circularly heated, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding 18 parts of grease substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 38 parts of chitosan, 27 parts of calcium polyglutamate, 4 parts of plasticizer and 18 parts of hyaluronic acid into 112 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding 13 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in the menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
Example seven
The embodiment discloses a process for preparing a targeted wound biomass repair dressing in the first embodiment, wherein some materials required in the preparation process need to be prepared in advance, and the preparation method of the calcium polyglutamate comprises the following steps: and (3) dissolving polyglutamic acid in deionized water, stirring to fully dissolve and uniformly mix the polyglutamic acid, slowly adding the dissolved calcium salt solution, and chelating for 3 hours at 65 ℃ to prepare the aqueous solution.
The polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
The grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
The antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
The preparation process of the targeted wound biomass repair dressing comprises the following steps:
s1, dispersing 60 parts of polymer thickening material with water, putting into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding 7 parts of bacteriostat and 3 parts of surfactant into the mixture A which is circularly heated, stirring and mixing to obtain a mixture B, wherein the mixture B has the function of resisting bacterial invasion, can prevent wound infection, has no cytotoxicity and acute toxicity, has no irritation and sensitization to skin, has good histocompatibility, and has good medical application prospect;
s3, adding 20 parts of grease substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring 40 parts of chitosan, 30 parts of calcium polyglutamate, 5 parts of plasticizer and 20 parts of hyaluronic acid into 120 parts of water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into 15 parts of silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
The following table is obtained by measuring chitosan content by high performance liquid chromatography, sensitization by GB/T16886.10-2005 standard, intradermal irritation, and bacteriostasis by GB19489 cells of the biomass repair dressing prepared in example 2 to example 7:
from the table, the fifth embodiment of the wound-targeted biomass repair dressing is the best embodiment, the last three groups have obvious antibacterial effect, and the diameters of the antibacterial rings are increased along with the increase of the concentration of chitosan, and the first three groups have no antibacterial rings, so that a proper amount of chitosan content can effectively kill staphylococcus aureus, achieve the antibacterial effect, have no irritation and sensitization to skin, have the functions of resisting bacteria, diminishing inflammation, reducing infection probability in the wound healing process, stopping bleeding quickly and the like, and can meet the effect of wound-targeted biomass repair.
The invention relates to a targeted wound biomass repair dressing and a preparation process thereof, wherein the preparation method and the use mode of a menstrual blood derived mesenchymal stem cell solution are both the prior art, and the invention is not described in detail.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. The targeted wound biomass repairing dressing is characterized by comprising the following raw materials in parts by weight:
30-40 parts of chitosan, 15-30 parts of calcium polyglutamate, 5-15 parts of hyaluronic acid, 8-20 parts of silica gel, 40-60 parts of high polymer thickening material, 1-5 parts of plasticizer, 3-7 parts of bacteriostat, 1-3 parts of surfactant, 10-20 parts of grease substance and 80-120 parts of water.
2. The wound-targeted biomass repair dressing of claim 1, wherein: the high polymer thickening material is composed of polyvinyl alcohol 1788, sodium polyacrylate, sodium alginate, xanthan gum and Caesalpinia spinosa champ in a weight ratio of 4:3:5:2:6.
3. The wound-targeted biomass repair dressing of claim 1, wherein: the grease substance is simethicone, caprylic/capric glyceride and vitamin E according to the weight ratio of 6:2:4.
4. The wound-targeted biomass repair dressing of claim 1, wherein: the antibacterial agent comprises methylparaben, propylparaben, p-hydroxyacetophenone, sodium benzoate, etc.
5. The wound-targeted biomass repair dressing of claim 1, wherein: the calcium polyglutamate is prepared by dissolving polyglutamate in deionized water, stirring to fully dissolve and mix the polyglutamate, slowly adding a calcium salt solution, and chelating for 3 hours at 65 ℃.
6. A process for preparing a wound-targeted biomass repair dressing according to any one of claims 1 to 5, comprising the steps of:
s1, dispersing a polymer thickening material with water, putting the polymer thickening material into a homogenizer for stirring for 3 hours, then heating to 45 ℃ and stirring for 2 hours to obtain a mixture A, and circularly heating the mixture A;
s2, adding a bacteriostatic agent and a surfactant into the mixture A after cyclic heating, and stirring and mixing to obtain a mixture B;
s3, adding oil and fat substances into the mixture B, and putting the mixture into a homogenizer for stirring for 5 hours;
s4, respectively pouring chitosan, calcium polyglutamate, plasticizer and hyaluronic acid into water, and then mixing and stirring uniformly to obtain a mixed solution;
s5, adding the mixture B into the mixed solution, slowly adding the mixture B into the silica gel, stirring to obtain mixed gel, regulating the pH of the mixed gel to 5.8-6.4, soaking the mixed gel in the menstrual blood derived mesenchymal stem cell solution for 10-20 minutes, and taking out to obtain the biomass repair dressing.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109432490A (en) * | 2018-10-17 | 2019-03-08 | 苏州汇涵医用科技发展有限公司 | A kind of transparent aquagel and its preparation method and application |
| CN110694096A (en) * | 2019-11-20 | 2020-01-17 | 湖北双星药业股份有限公司 | Active wound and facial skin repair dressing and preparation method thereof |
| CN113069591A (en) * | 2021-03-29 | 2021-07-06 | 黄河三角洲京博化工研究院有限公司 | Chitosan-calcium polyglutamate biological dressing and preparation method thereof |
| CN114917184A (en) * | 2022-06-09 | 2022-08-19 | 溃克药业(哈尔滨)有限公司 | Viscous medical dressing and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432490A (en) * | 2018-10-17 | 2019-03-08 | 苏州汇涵医用科技发展有限公司 | A kind of transparent aquagel and its preparation method and application |
| CN110694096A (en) * | 2019-11-20 | 2020-01-17 | 湖北双星药业股份有限公司 | Active wound and facial skin repair dressing and preparation method thereof |
| CN113069591A (en) * | 2021-03-29 | 2021-07-06 | 黄河三角洲京博化工研究院有限公司 | Chitosan-calcium polyglutamate biological dressing and preparation method thereof |
| CN114917184A (en) * | 2022-06-09 | 2022-08-19 | 溃克药业(哈尔滨)有限公司 | Viscous medical dressing and preparation process thereof |
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