CN116407484A - Skin care composition for repairing skin barrier and application thereof - Google Patents
Skin care composition for repairing skin barrier and application thereof Download PDFInfo
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- CN116407484A CN116407484A CN202111638778.1A CN202111638778A CN116407484A CN 116407484 A CN116407484 A CN 116407484A CN 202111638778 A CN202111638778 A CN 202111638778A CN 116407484 A CN116407484 A CN 116407484A
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- skin
- care composition
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a skin care composition for repairing skin barrier and application thereof. The skin care composition comprises an active ingredient combination for repairing a skin barrier comprising a saccharomyces cerevisiae fermentation product lysate, sialic acid, and a pH adjuster, wherein the pH adjuster is used in an amount such that the pH of the resulting skin care composition is not less than 4.5. Compared with the lysate of the fermentation product of the saccharomyces cerevisiae, the invention adopts the combination of the lysate of the fermentation product of the saccharomyces cerevisiae and sialic acid, and can improve the effect of repairing the skin barrier.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a skin care composition for repairing skin barrier and application thereof.
Background
Defective skin barriers can allow more moisture to be lost from the skin and the ingress of external stimuli (e.g., allergens, toxins) to trigger dryness, redness, itching, etc. of the skin. Factors that cause skin to fail in completing the barrier function are various, such as damage to the skin due to ultraviolet rays, or the regeneration of the barrier function of human skin after being stimulated becomes more and more problematic with age.
The barrier function of the skin is mainly represented by the stratum corneum, which is the outermost layer of the skin. The stratum corneum is composed of necrotic keratinocytes and intercellular lipids, and serves as a skin protective film that protects the skin from external stimuli, prevents evaporation of water from the inside, and is responsible for core functions. At the same time, the stratum corneum not only plays a barrier function, but also influences the function, and structure of the cell layers present in the interior, i.e., the epidermis layer or dermis layer.
The lysate of the fermentation product of the saccharomyces cerevisiae, the English name is BIFIDA FERMENT LYSATE, is a generic name of a metabolite, a cytoplasmic fragment, a cell wall component and a polysaccharide complex which are obtained by culturing, inactivating and decomposing bifidobacteria, comprises small molecules such as vitamin B group, mineral substances, amino acids and the like which are beneficial to skin care, and is a high-quality yeast essence which is very suitable for skin care. The lysate of the fermentation product of the saccharomyces cerevisiae can strengthen the metabolism of horny layer, has strong anti-immunosuppression activity, can promote DNA repair, can effectively protect skin from being damaged by ultraviolet rays, and has the effects of enhancing skin immunity and repairing skin barriers.
However, the lysate of the fermentation product of the saccharomyces cerevisiae is difficult to obtain raw materials with high effective content due to factors such as raw material stability, and the like, so that the lysate is high in addition amount during application, and the economic cost cannot be ignored.
Disclosure of Invention
It is an object of the present invention to provide a skin care composition which is capable of repairing the skin barrier, thereby improving the skin moisturization.
In order to achieve the above object, the present invention provides the following technical solutions:
a skin care composition comprising a combination of active ingredients for repairing a skin barrier, the combination of active ingredients comprising a saccharomyces cerevisiae fermentation product lysate, sialic acid, and a pH adjusting agent, wherein the pH adjusting agent is used in an amount such that the pH of the resulting skin care composition is not less than 4.5.
As the known technology, the lysate of the fermentation product of the saccharomyces cerevisiae is also called as lysate of the fermentation product of the saccharomyces cerevisiae, and some cases can be abbreviated as the saccharomyces cerevisiae, which contains vitamin B group, mineral substances, amino acid and other skin-friendly small molecules, can strengthen metabolism of horny layer, has strong anti-immunosuppression activity and can promote DNA repair, thereby having the effects of enhancing skin immunity and repairing skin barrier.
Compared with the method that the yeast fermentation product lysate is used as the active ingredient for repairing the skin barrier, the method has the advantages that the yeast fermentation product lysate is compounded with sialic acid and then used together, the obtained active ingredient combination can obviously improve the effect of repairing the skin barrier, but the yeast fermentation product lysate and the sialic acid are both partial acidic substances, skin injury can be caused when the yeast fermentation product lysate is directly used for normal skin, especially for people with thin horny layer, in order to avoid skin problems such as skin redness and inflammation and poor skin feel problems such as stinging and burning, and the pH regulator is added to balance the skin use feeling. The sialic acid is also called N-acetylneuraminic acid, nidus Collocaliae acid and nidus Collocaliae essence.
The pH regulator is mainly alkaline substances such as arginine, betaine, triethanolamine and the like commonly used in cosmetics, can achieve the aim of the invention, and the dosage of the pH regulator is not excessively limited. However, in one embodiment of the present invention, it is shown that when the basic substance is selected to be arginine, it has a better effect than other pH adjusting agents.
In a preferred embodiment, the mass ratio of lysate to sialic acid of the fermentation product of Saccharomyces cerevisiae is 1 (0.1-3).
In a further preferred embodiment, the mass ratio of lysate of the fermentation product of Saccharomyces cerevisiae, sialic acid is 1 (0.6-1.5).
In the most preferred embodiment, the mass ratio of the lysate of the fermentation product of the Saccharomyces cerevisiae to sialic acid is 1 (0.8-1.2).
Experiments show that in the proportion range, the lysate of the fermentation product of the saccharomyces cerevisiae and sialic acid can improve the effect of repairing the skin barrier more remarkably.
Since the lysate of the fermentation product of the Saccharomyces cerevisiae currently commercially available is mostly an aqueous solution or other mixture, the mass or weight content of the lysate of the fermentation product of the Saccharomyces cerevisiae can be calculated according to the identified effective content.
In a preferred embodiment, the skin care composition comprises:
0.1 to 20% by weight of said active ingredient combination;
wherein each weight% is relative to the total skin care composition.
In the skin care composition, the conventional amount of the active ingredient combination for repairing the skin barrier is 0.1 wt% or more, and when the amount of the active ingredient combination exceeds 20 wt%, harmful irritating side effects may be generated to the human body, so that it is not preferable.
In a preferred embodiment, the skin care composition described above, the skin barrier is characterized by reduced moisture loss from the skin and improved skin moisturization. The stratum corneum, which is the first protective film of the skin, is not only vulnerable to the external environment, but also the skin barrier function of the stratum corneum is not successfully achieved or is damaged if the skin is a dry person. In order to impart moisture retention to dry skin, the problem is generally solved temporarily by applying a moisturizer formulation, but it is difficult to solve the fundamental problem, and further, the skin barrier damaged by ultraviolet rays cannot be improved by simply applying a moisturizer formulation.
In another preferred embodiment, in the above skin care composition, the skin barrier is characterized by inhibiting uv-induced skin damage.
The invention is to prevent skin injury caused by ultraviolet rays, and is understood to be the effect of preventing further deterioration, damage and denaturation of the skin and repairing the occurred photoinjury by the active ingredient combination in the irradiation process of the skin which is damaged or is to be damaged by ultraviolet rays; the meaning of inhibition can be synonymous as slowing down, relieving, alleviating, repairing, treating and the like; skin injury refers to the phenomenon of increased dandruff, desquamation, local hardening, roughness, thickening, dryness and the like on the surface of skin under the toxic action of ultraviolet light, or the phenomenon of various cell swelling, enlargement and the like in the epidermis and dermis of the skin.
Further, the inhibition of skin damage caused by ultraviolet rays is to slow down abnormal keratosis of photoaged skin; or, inhibiting photoaging skin thickening; or, the malondialdehyde content in blood is reduced.
The slowing and repairing of the invention is understood to be that when the active ingredient combination acts on the slightly or severely damaged parts of the skin such as dander, dryness, hardening and the like in the irradiation process of excessive light or daily light, the phenomena such as softness, dander reduction and the like of the damaged skin can be recovered, and the slowing or repairing is synonymous as alleviation, treatment, alleviation, inhibition, repairing and the like.
The abnormal keratosis of the skin refers to the phenomena that the epidermis is obviously thickened, keratinocytes are enlarged, keratinization is excessive and the like after phototoxic skin is formed.
The content of malondialdehyde measured in the invention can reflect the peroxidation degree of body lipid based on the content characteristics of malondialdehyde, and the content can be used as one of indexes for examining the severity of stress on cells.
In a preferred embodiment, the skin care composition is in the form of a facial cleanser, essence, skin lotion, cream, ointment, mask, cosmetic lotion or foundation. Meanwhile, it may appropriately contain components commonly used in cosmetic products or skin external preparations, for example, moisturizers, antioxidants, surfactants, oily components, UV absorbers, emulsifiers, thickeners, aqueous components, water, and various skin application agents, etc., as needed, within a range not impairing the effects of the present invention.
In the present invention, unless otherwise specified:
as used herein, "comprising" is intended to mean "including but not necessarily consisting of … …". In other words, the listed choices are not necessarily exhaustive.
As used herein, "skin care composition" is meant to include compositions for topical application to the skin of a mammal, particularly a human. Such compositions can generally be classified as leave-on or rinse-off, preferably leave-on.
"skin" as used herein is meant to include skin on the face and body (e.g., neck, chest, back, arms, hands, legs, etc.), preferably facial skin.
The beneficial effects obtained by the invention are as follows:
the invention provides a skin care composition which comprises an active ingredient combination for repairing skin barriers, wherein the active ingredient combination adopts the combination of a lysate of a fermentation product of saccharomyces cerevisiae, sialic acid and a pH regulator, so that the effect of repairing the skin barriers can be improved, and the risk of irritation to the skin can be reduced.
Detailed Description
The following examples are illustrative of the invention and are not intended to limit the scope of the invention. The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications.
In the following examples and comparative examples, the Saccharomyces cerevisiae fermentation product lysate was derived from Synsil, U.S. wherein the active ingredient Saccharomyces cerevisiae fermentation product lysate content was 25%, and sialic acid was the sialic acid starting material (content 98%) commercially available to the applicant. In the examples, the mass components of the lysate of the fermentation product of Saccharomyces cerevisiae are converted according to the identified effective content.
The final pH of all examples was adjusted to 5.5±0.2.
Example 1
The present example provides a skin care composition consisting of the following components:
example 2
The present example provides a skin care composition consisting of the following components:
example 3
The present example provides a skin care composition consisting of the following components:
example 4
The present example provides a skin care composition consisting of the following components:
comparative example 1
The comparative example provides a skin care composition consisting of the following components:
comparative example 2
The comparative example provides a skin care composition consisting of the following components:
comparative example 3
The comparative example provides a skin care composition consisting of the following components:
test example 1 irritation test
This test example is directed to the skin care compositions provided in example 1, comparative examples 1-2, for skin irritation and skin feel upon application thereto, and is specifically as follows:
the skin care compositions provided in example 1, comparative example 2 were used by 15 non-pregnant women between 20-40 years of age as subjects, randomized into 3 groups of 5 persons each.
The test method comprises the following steps: the product was subjected to the human skin patch test by referring to the cosmetic safety technical Specification (2015 edition), and the skin closed patch test mode was used for 0.5h, and after the patch tester was removed for 0.5h, the irritation was judged according to Table 1, and the total score was the sum of personal scores/number of people.
TABLE 1 skin response grading Standard for skin seal Patch test
Test results: example 1 scored 0, comparative example 1 scored 0.2, and comparative example 2 scored 0. In addition, 3 of the subjects of comparative example 1 showed a remarkable stimulus sensation, and, taken together, comparative example 1 was not suitable for continuing the subsequent experiments.
Test example 2 skin barrier repair
This test example is directed to the skin barrier repair function of the skin care compositions provided in examples 1-4, comparative example 2, and is specifically as follows:
the skin care compositions provided in examples 1-4 and comparative example 2 were used on a randomized basis in 5 groups of 5 subjects from 25 non-pregnant women between 25 and 40, each of the test months, and were prepared for use during the evening and morning of the day, as no additional stabilizer ingredients were added.
The test method comprises the following steps: after washing in the morning and evening, 0.5mL of the skin care composition was applied to the cheek for 4 weeks, and no additional skin care product was applied to the test area during the test.
The testing method comprises the following steps: the amount of percutaneous water loss TEWL at cheek sites was measured at week 0, week 2 and week 4 respectively using TM300 from CK corporation in germany and averaged (retained to the decimal point later). The test results are shown in Table 2.
TABLE 2TEWL test results
| Week 0 g/m 2 h | Week 2 g/m 2 h | Week 4 g/m 2 h | |
| Example 1 | 19.1 | 16.4 | 15.8 |
| Example 2 | 19.3 | 17.0 | 16.5 |
| Example 3 | 18.9 | 16.8 | 16.2 |
| Example 4 | 19.1 | 17.2 | 16.9 |
| Comparative example 2 | 18.8 | 17.4 | 17.0 |
Test example 3 ultraviolet repair test
This example is directed to the skin care compositions provided in example 1 and comparative examples 2-3 for inhibiting uv-induced skin aging, and the specific procedure is as follows:
1. test materials
1.1 test sample
Skin care compositions provided in example 1 and comparative examples 2-3.
1.2 blank
The blank is purified water.
1.3 laboratory animals
ICR mice, SPF grade, females for the test; weight of: 18-22 g, provided by all of the liability company of the Wuhan biological research.
Feeding conditions: the test animals are kept in cages, and 6-8 animals are kept in each cage. The feed is SPF-grade experimental granular mouse food and can be purchased commercially. The drinking water is sterilized purified water. The cage bottom padding is poplar wood chips, sterilized before use,
the replacement is carried out every two days. The laboratory temperature is 20-22 ℃, the humidity is 55-60%, and the light and shade period is 12 hours.
1.4 reagents
Methoxysarin (8-methoxy psoralea), 1 g/bottle, SLBC0610V, purchased from Sigma-Aldrich. Before use, the extract is dissolved in 95% ethanol and diluted into 1% concentration solution for use in dark place.
Superoxide dismutase (SOD) kit (WST-1 method): commercially available.
Malondialdehyde (MDA) kit: commercially available.
1.5 instruments
The HOPE-MED 8130 skin phototoxicity experiment instrument, the ultraviolet spectrometer UV-A, TU1950 ultraviolet spectrophotometer, the INFINITE M200 fluorescence multifunctional enzyme labeling instrument, the ASP200S full-automatic tissue dehydrator, the EG1150 paraffin embedding machine, the HI1210 tablet spreading machine, the RM2265 full-automatic slicing machine and the DM2500 photomicrograph can be commercially available.
2. Test method
2.1 method of Forming mold
50 ICR female mice were adapted for 1 week. The hair on the back of the mice was removed by the rosin paraffin dehairing method, and the area was 2 cm. Times.3 cm. After dehairing, 40 mice are taken as Sup>A model set, and after 0.1ml of methoxsalen solution is smeared on the exposed part of the back skin for 1 hour, the mice are fixedly arranged in Sup>A skin phototoxicity experiment instrument by Sup>A transparent mouse fixer, and the mice are irradiated at Sup>A position about 15cm away from Sup>A light source (the energy measured by an ultraviolet radiometer UV-A is 2.25 mW/cm) 2 ) The method comprises the steps of carrying out a first treatment on the surface of the Another 10 mice served as normal controls without methoxsalen solution and without irradiation. The mice for making the modules are coated with the methoxsalen solution for 1 hour every day and then irradiated once for 15 minutes each time for 2 weeks continuously; the methoxsalen is not smeared for direct irradiation once every day, and each time lasts for 15 minutes and 3 weeks. All mice were shaved every two days with animals shaved Mao Qiti Mao Yici to shave back bare skin hair.
2.2 grouping and administration of animals
40 mice were successfully modeled (randomly divided into 3 groups according to the degree of back skin photodamage: example 1 group (10), comparative example 2 group (10), comparative example 3 group (10) and model control group (10).
Example 1 and comparative examples 2-3 were prepared by diluting the skin care composition 10 times and then applying 0.2mL, the model control group was given the same volume of purified water, and after 30 minutes, the skin care composition was fixed in a skin phototoxicity tester with a transparent mouse holder and irradiated at a distance of about 15cm from the light source, once a day for 15 minutes each time. The same procedure was continued for 5 weeks. All mice were shaved every two days with animals shaved Mao Qiti Mao Yici to shave back bare skin hair. The normal control group was not irradiated.
2.3 experimental observations and materials
The skin smoothness, color and softness and elasticity of each group of mice were visually observed during the experiment. 24 hours after the last administration irradiation, the administration group and model group mice take blood of about 1.0ml from the orbital venous plexus, centrifuge at 3000rpm for 10min, take serum, remove cervical vertebra and sacrifice, take the whole skin of the back dehairing area, fix in 10% neutral formalin solution, and make histopathological section; serum was used to detect MDA content and SOD activity. Normal control mice were operated in the same manner.
3. Test results
3.1 visual inspection during the test
The back skin of the normal control group mice is smooth, tender and elastic; skin of the mice in the model control group gradually appears dander, dryness and partial desquamation along with the increase of irradiation time, and the skin is dark in color, locally hardened and rough and hypertrophic; after the sample group mice are irradiated and coated with the medicines, skin injury is relieved to different degrees, and the phenomena of light color, reduced dander and the like are caused.
3.2 influence of nidus Collocaliae acid on MDA content in serum of photoaged mice
Table 3 influence of cubilose acid on MDA content of photoaged mouse model
| Group of | Number of animals (n) | MDA content (nmol/l) |
| Normal control group | 10 | 21.16±2.26 |
| Model control group | 10 | 28.21±6.02 △△ |
| Example 1 group | 10 | 22.83±4.04** |
| Comparative example 2 group | 10 | 25.85±2.68** |
| Comparative example 3 group | 10 | 24.15±2.35** |
Note that: delta represents p <0.01 compared to the normal control group; * Represents p <0.01 compared to model control group.
The results in table 3 show that the MDA content in the serum of each group of mice is significantly increased compared with the normal control group, which indicates that the modeling of the skin photoaging model of mice is successful.
Compared with a model control group, the three groups of samples can obviously reduce the MDA content in serum, and have statistical significance, but the effect of adding the lysate of the fermentation product of the saccharomyces cerevisiae and the sialic acid group is more obvious.
3.3 pathological tissue section examination
For each experimental group of mice skin histopathological section, each tissue is selected to have 5 visual fields, the thickness of epidermis and dermis is measured under the microscope with LASV4.0 software, and statistical calculation is performed, and the results are shown in Table 4:
TABLE 4 influence of bird's nest acid on the thickness of epidermis and dermis of photoaged mouse models
Note that: delta represents p <0.01 compared to the normal control group; * Represents p <0.01 compared to model control group.
The three sample groups showed reduced epidermal thickening and keratinization, and reduced dermal fibrosis and thickening compared to the model control group. But the effect of example 1 is more pronounced.
While the invention has been described in detail in the foregoing general description, embodiments and experiments, it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (9)
1. A skin care composition comprising a combination of active ingredients for repairing skin barrier, said combination of active ingredients comprising a saccharomyces cerevisiae fermentation product lysate, sialic acid and a pH adjusting agent, wherein the pH adjusting agent is used in an amount such that the pH of the resulting skin care composition is not lower than 4.5.
2. The skin care composition according to claim 1, wherein the mass ratio of lysate of fermentation product of Saccharomyces cerevisiae to sialic acid is 1 (0.1-3).
3. The skin care composition according to claim 1 or 2, wherein the mass ratio of lysate of fermentation product of Saccharomyces cerevisiae to sialic acid is 1 (0.6-1.5).
4. A skin care composition according to any one of claims 1 to 3 wherein the mass ratio of lysate of the fermentation product of saccharomyces cerevisiae, sialic acid is 1 (0.8-1.2).
5. The skin care composition according to any one of claims 1-4 comprising:
0.1 to 20% by weight of said active ingredient combination;
wherein each weight% is relative to the total skin care composition.
6. The skin care composition of any one of claims 1-5 wherein the skin barrier is characterized by reduced moisture loss from the skin and improved skin moisturization.
7. The skin care composition of any one of claims 1-6 wherein the repair of the skin barrier is characterized by inhibition of uv-induced skin damage.
8. The skin care composition of claim 7 wherein said inhibition of uv-induced skin damage is a reduction in abnormal keratosis of the skin; and/or inhibiting photo-aged skin thickening; and/or reducing malondialdehyde content in blood.
9. A skin care composition according to any one of claims 1 to 8 in the form of a facial cleanser, essence, skin lotion, cream, ointment, mask, cosmetic lotion or foundation.
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