CN116356008A - Congenital heart disease related SETD2 gene new variation site and application thereof - Google Patents

Congenital heart disease related SETD2 gene new variation site and application thereof Download PDF

Info

Publication number
CN116356008A
CN116356008A CN202111631410.2A CN202111631410A CN116356008A CN 116356008 A CN116356008 A CN 116356008A CN 202111631410 A CN202111631410 A CN 202111631410A CN 116356008 A CN116356008 A CN 116356008A
Authority
CN
China
Prior art keywords
seq
site
primer
new
heart disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111631410.2A
Other languages
Chinese (zh)
Inventor
秦胜营
李沫
贺林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Jiaotong University
Original Assignee
Shanghai Jiaotong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Jiaotong University filed Critical Shanghai Jiaotong University
Priority to CN202111631410.2A priority Critical patent/CN116356008A/en
Publication of CN116356008A publication Critical patent/CN116356008A/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/38Pediatrics
    • G01N2800/385Congenital anomalies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to a congenital heart disease related SETD2 gene new variation site and application thereof; the nucleotide sequence of the gene is shown as SEQ ID NO.1, the new mutation site is positioned at 43529 th site, chr3:47120450 is T-A and 79848 th site, and rs769925323 is T-C. The invention relates to a method for detecting the nucleotide variation, which comprises the following steps: step one, collecting three family samples, and typing potential new mutation sites of the sequences; step two, the genetic variation at positions 43529 and 79848 was analyzed using Sanger sequencing. The invention lays a foundation for researching the relation between new variation of the SETD2 gene and congenital heart disease, provides a molecular target for predicting the risk of suffering from congenital heart disease, and simultaneously provides a theoretical basis for early screening of congenital heart disease based on the gene.

Description

Congenital heart disease related SETD2 gene new variation site and application thereof
Technical Field
The invention belongs to the technical field of molecular diagnosis and gene detection, relates to new variation of congenital heart disease candidate genes and correlation of the new variation with congenital heart disease candidate genes, in particular to an identification and application method of new variation of SETD2 genes in the technical field of gene detection, and particularly relates to new variation sites of the related SETD2 genes of congenital heart diseases and application of the new variation sites.
Background
Congenital heart disease (Congenital heart disease, CHD) is a major class of developmental deformities of the heart involving structural and functional defects of the heart, with an incidence of 0.5-1% in live infants. CHD is the most common birth defect in humans, severely jeopardizing infant health, where the bluish violet congenital heart disease is the leading cause of complex deformity and high mortality in infants. More than 10 tens of thousands of congenital heart disease infants born in China are born annually, of which about 80% are simple CHD without syndrome. Although modern genetics and imaging have made great progress in the study of the genetic and molecular mechanisms of CHD, a significant proportion of CHD patients are still unknown in their pathogenesis and are treated primarily by surgical means. Even if CHD patients survive through surgical correction, severe problems such as pulmonary arterial hypertension, heart failure complications and the like still occur in the future, and huge pains and economic burdens are brought to the patients and families thereof. The elucidation of CHD pathogenesis is the basis for improving early intervention, prevention and control and treatment of CHD, and has great scientific value and social significance for improving the health and birth population quality of children in China. Through large-scale complete genome sequencing of the CHD family and combination of clinical gene detection technology, the method is beneficial to perfecting the genomics and clinical data of the CHD in China and further elucidating the pathogenesis of the CHD, provides theoretical basis for molecular diagnosis thereof, and also provides a new idea for researching the etiology of similar diseases.
Factors known to cause CHD are mainly environmental and genetic factors. The environmental factors mainly comprise medicines taken in gestation period, virus infection, environmental pollution, radiation, etc. Compared with complex environmental factors, the genetic factors are easy to quantitatively analyze. Since the first demonstration of CHD induction by heterozygous mutations in the NKX2-5 gene, genetic factors have been increasingly gaining importance in CHD development. To date, tens of genes associated with simple CHD have been found in humans, including transcription and regulatory factor genes during cardiac formation (e.g., NKX2-5, tbx1 and GATA 4), developmental signaling pathway molecular genes (e.g., NOTCH2 and JAG 1), cardiac structural genes (e.g., ELN and MYH 6), and the like. Both loss of function (LOF) mutations and gain of function (GOF) mutations of related genes can lead to CHD. However, currently known single-gene variation can only explain 3-5% of simple CHD, and the discovery and identification of new CHD related genes are scientific problems to be solved urgently.
CHD is complex in etiology and has a variety of clinical phenotypes. For example: fallotetraia (Tetralogy of Fallot, TOF), pulmonary arterial occlusion/ventricular septal defect (Pulmonary atresia/ventricular septal defect, PA/VSD), perpetuating arterial trunk (Permanent truncus arteriosus, PTA), aortic arch dissection (interrupted aortic arch, IAA), aortic transposition (Transposition of the great arteries, TGA), right ventricular double outlet (Double outlet right ventricle, DORV), and the like. Elucidating the genetic characteristics and pathogenesis of different types of CHD will greatly promote the research of CHD etiology and provide theoretical support for molecular diagnosis and early intervention thereof. Because of the complex mechanism of onset of the congenital heart disease, it is particularly important to select a suitable sample in the family and to take a suitable strategy for research. The collection of the congenital heart disease families not only provides a favorable guarantee for exploring the occurrence mechanism of the congenital heart disease, but also can discover new disease phenotypes, reveal new functions of pathogenic genes and provide a direction for research of the pathogenic genes.
In recent years, the development of high-throughput sequencing technology brings new opportunities for research on genetic etiology of complex diseases such as CHD. Analysis of the full exome data of the largest scale CHD cohort (2871 pre-evidence, of which 2645 core families) to date showed that new variations of about 440 genes are associated with CHD, with new autosomal dominant genetic variations and autosomal recessive genetic variations accounting for 8% and 2%, respectively; page et al found that pathogenic variation significantly aggregated in NOTCH1 and FLT4 in 829 Fabry-Perot quadruple (TOF) patients by whole-exome sequencing technique, and that variation of these 2 genes could explain 6.9% of TOF cases enrolled by the study; liu et al, through sequencing studies of the complete exome of the aortic translocated infant and core family (trio), found that pathogenic mutations are enriched in cilia-related genes, and that some cases show either oligogenic or polygenic genetic patterns. However, current research into genetic causative factors of CHD has been focused mainly on the protein-encoding gene, and there are a large number of non-coding regions, which are closely related to the embryonic heart development process and are also key factors for CHD. The clinical samples can be analyzed by whole genome sequencing, so that common variation and rare variation can be detected, and variation information of a protein coding region and a non-coding region can be obtained simultaneously, thereby being a necessary path for comprehensively revealing the genetic etiology of CHD.
The SETD2 gene expresses an H3K36me3 specific methyltransferase, H3K36me3 being a specific marker of epigenetic transcriptional activation. The protein plays a role in chromatin structure regulation by coordinating the recruitment of the FACT complex and the interaction with hyperphosphorylated POLR 2A. The protein also contains a novel transcriptional activation domain and has been found to be associated with hyperphosphorylated RNA polymerase II. Deletion of the SETD2 gene results in a wide variety of oocyte epigenoids which in turn control embryo development. Although there have been many reports of the correlation of various types of variation on genes with congenital heart disease, there are no reports of the correlation of the SETD2 gene with congenital heart disease, and there are no reports of the correlation of the new variation with congenital heart disease. Therefore, the invention provides the application value of the SETD2 gene in screening congenital heart diseases for the first time, which not only has great significance for early intervention of congenital heart diseases, but also provides an important clue for exploring pathogenesis of congenital heart diseases.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a detection method for new variation of SETD2 genes. The invention lays a foundation for researching the relation between new variation of SETD2 gene and congenital heart disease, provides a theoretical basis for early intervention of congenital heart disease, and also provides an important clue for exploring pathogenesis of congenital heart disease.
The invention is realized by the following technical proposal,
in a first aspect, the invention provides an isolated nucleotide containing a novel mutation site, the sequence of the nucleotide is shown as SEQ ID NO.1, the novel mutation site is located at position 43529, chr3:47120450 is T-A and position rs769925323 at position 79848 is T-C.
In a second aspect, the invention provides an isolated nucleotide having a sequence as set forth in SEQ ID NO:1, and 43529 is T while 79848 is T.
In a third aspect, the invention provides the use of the isolated nucleotide containing a new mutation site as a molecular marker of congenital heart disease, or in the preparation of a reagent or kit for assisting in screening or detecting congenital heart disease.
As one embodiment of the invention, the reagent comprises a primer, a probe, a chip or an antibody.
As an embodiment of the invention, the kit contains one or more reagents selected from the group consisting of:
(a) Specific primers for detecting one or both of said novel mutation sites;
(b) A specific probe for detecting one or both of said novel mutation sites;
(c) A chip for detecting one or two of the new variation sites;
(d) And the specific antibody is used for detecting the mutation of one or two amino acids corresponding to the new mutation sites.
As one embodiment of the invention, the new mutation site is located at 43529 th site, chr3:47120450 is T.fwdarw.A, and the primer is:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the new mutation site is positioned at 79848 th site, rs769925323 is T-C, and the primer is:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
the reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
In a fourth aspect, the invention provides a kit for aiding in the screening or detection of congenital heart disease, said kit comprising: according to the sequence set forth in SEQ ID NO:1, and primer pairs designed by new mutation sites chr3:47120450 and rs769925323 of the sequence shown in the specification.
As one embodiment of the invention, the primer pair of the novel mutation site chr3:47120450 is as follows:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the primer pair of the new mutation site rs769925323 is as follows:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
the reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
In a fifth aspect, the present invention provides a method of using the kit for non-diagnostic purposes, the method comprising the steps of:
s1, extracting DNA of three family samples;
s2, amplifying by using the primer pair to obtain an amplified product;
s3, detecting whether new mutation sites chr3:47120450 and rs769925323 shown in SEQ ID NO.1 exist in the family child sample by adopting a Sanger sequencing method.
As an embodiment of the present invention, step S3 includes the steps of: the taken samples were typed at positions chr3:47120450 and rs769925323 using an ABI 3730XL PCR instrument to detect the presence of genetic variation at positions 43529 and 79848.
As one embodiment of the present invention, the amplification product in step S2 has a length of 50 to 150bp.
As one embodiment of the present invention, the length of the primer in step S2 is 15-25bp.
As one embodiment of the present invention, the total volume of the amplification reaction system in step S2 is 50. Mu.l, wherein,
Figure BDA0003440300120000041
as one embodiment of the invention, the amplified PCR reaction conditions: 94 ℃ for 2mins;40× (94 ℃ 30s;58 ℃ 30s,72 ℃ 30 s); and at 72℃for 10mins.
In a sixth aspect, the invention provides a special primer pair for detecting SNP loci containing new variation loci, the sequence of the nucleotides is shown as SEQ ID NO.1,
the new mutation site is positioned at 43529 th site, chr3:47120450 is T-A, and the primer pair is:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the new mutation site is positioned at 79848 th site, rs769925323 is T-C, and the primer pair is:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
the reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
In a seventh aspect, the invention also provides an isolated SETD2 amino acid sequence having one or more mutations selected from the group consisting of: amino acid Asn (N) →Lys (K) at position 1396, amino acid Ile (I) →Val (V) at position 1884.
Compared with the prior art, the invention has the following beneficial effects:
the invention lays a foundation for researching the relation between new variation of the SETD2 gene and congenital heart disease, provides a molecular target for predicting the risk of suffering from congenital heart disease, and simultaneously provides a theoretical basis for early screening of congenital heart disease based on the gene.
Detailed Description
The invention will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. The experimental procedure, which does not address specific conditions in the following examples, is generally followed by conventional conditions, such as molecular cloning by Sambrook et al: conditions described in the laboratory Manual (New York: cold Spring Harbor Laboratory Press, 1989) or as recommended by the manufacturer.
Example 1
The invention relates to a screening and obtaining method of new mutation at 43529 th and 79848 th positions of SETD2 gene, and also relates to a detection method and related separated nucleotide and primer. According to the invention, through family analysis of whole genome sequencing, SNP chr3:47120450 and rs769925323 on an exon region of the SETD2 gene can be used as molecular markers of congenital heart disease, and specific information of the gene is SETD2 gene LOCUS NG_032091, and the total length is 147570bp.
Specifically, the experiment used Illumina TruSeq Nano DNA library prep kit to construct a whole genome sequencing library and sequenced on the Illumina NovaSeq platform. The high quality sequencing data was analyzed by quality assessment and processing of the off-the-shelf data followed by the read recommended bwa+gatk analysis procedure. The method comprises the following specific steps:
a) Family genetic analysis: and analyzing different family genetic modes through sequencing variation data, and rescreening genes carrying new single nucleotide variation of a plurality of coding regions in a plurality of families, namely finding SETD2 candidate genes.
B) SETD2 gene mutation frequency and toxicity analysis: the frequency and harmfulness of the observed novel mutation in the SETD2 gene was evaluated by the GnomAD database and CADD software (Table 1, typically CADD >20 is highly harmful).
C) Comparison analysis of new mutation data: by comparing the new variation information provided by the Gene4denovo database, the new variation of the SETD2 Gene was compared (table 2).
The invention adopts Sanger sequencing technology to detect the new SNP locus variation of the exon region of the SETD2 gene, and discovers the missense mutation of T-A at 43529 th site of the SETD2 gene, namely the 1396 th amino acid Asn (N) -Lys (K) in the protein sequence (NP-054878.5) encoded by the missense mutation; and a T.fwdarw.C missense mutation at position 79848, namely an amino acid Ile (I). Fwdarw.Val (V) at position 1884 in the protein sequence (NP-054878.5) encoded by the mutant. The SETD2 gene is located at the chromosome position: homo sapiens Chromosome, GRCH38.p13 (47016431.. 47164113), SNP chr3:47120450 variation at chromosomal position Chromosome 3:47120450,SNP rs769925323 at chromosomal position Chromosome 3:47084130. The specific nucleotide fragment sequence of the SETD2 gene is shown as SEQ ID NO.1, wherein the new mutation sites are positioned at 43529 th and 79848 th positions of the sequence.
The invention designs a related primer pair aiming at the SNP chr3:47120450 and the SNP rs769925323.
Specifically, primers are designed at the upstream and downstream of SNP chr3:47120450 and SNP rs769925323 of the exon region of the SETD2 gene, and the length of an amplified product is 50-150bp. And then typing the SNP loci chr3:47120450 and rs769925323 of the SETD2 gene of the obtained family samples by using an ABI 3730XL PCR instrument. It was found by analysis that the variation of chr3:47120450 resulted in amino acid Asn (N) to Lys (K) at position 1396 in the protein sequence (NP-054878.5), whereas SNP rs769925323 resulted in amino acid Ile (I) to Val (V) at position 1884 in the protein sequence (NP-054878.5). Since this is a substitution of amino acids of different nature, it results in a severe change in the activity of the protein encoded by the SETD2 gene.
The invention has a great number of analysis techniques for detecting whether new variations exist at the sites in the SETD2 gene exon. These techniques include (but are not limited to): DNA sequencing and hybridization sequencing; enzymatic mismatch cleavage, heteroduplex analysis, dot hybridization, oligonucleotide arrays (DNA chips), mini-sequencing, molecular beacons, and the like, denaturing High Performance Liquid Chromatography (DHPLC). In another aspect, the detection method of the invention is used to assess the relationship of the exon region SNP chr3:47120450 and SNP rs769925323 of the neonatal SETD2 gene to the occurrence of congenital heart disease. The test sample used in the present invention is not particularly limited, and for detecting SNP, DNA or mRNA extracted from a sample such as blood, tissue or the like may be used. For the activity of the exon region of the SETD2 gene, any sample containing the exon region of the SETD2 gene may be used, such as blood.
By "isolated or purified" is meant that at the genomic DNA level, the gene sequence of each new mutation site is amplified using a primer pair and the amplified product is purified using a purification kit.
The following is a specific implementation procedure of the scheme of the invention:
samples used in this example were taken from 290 congenital heart disease patients (age 0-6 years, table 3) and from a parent blood sample from the Shanghai pediatric medical center, all participants were signed by family members in a formal informed consent form. The genomic sequence of SETD2 to which this example relates is obtained from GenBank and is set forth in SEQ ID NO:1.
primer design: primers were designed using Primer-BLAST software and synthesized by Invitrogen corporation using the sequence of the GenBank database SETD2 gene (ID: 29072) as a template.
Primer information:
amplification of DNA sequence primer information of SNP chr3:47120450 locus of SETD2 gene:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' (SEQ ID NO: 2)
Reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' (SEQ ID NO: 3).
DNA sequence primer information of SNP rs769925323 locus of SETD2 gene is amplified:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' (SEQ ID NO: 4)
Reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' (SEQ ID NO: 5).
PCR amplification conditions: (reagents for the system are supplied by ABI, also available from published sources), the total volume of the reaction system is 50. Mu.l, where:
Figure BDA0003440300120000071
PCR reaction conditions: 94 ℃ for 2mins;40× (94 ℃ 30s;58 ℃ 30s,72 ℃ 30 s); and at 72℃for 10mins.
The PCR reaction is carried out in a 96-well plate, and is placed in an ABI 3730XL PCR instrument, the mutation conditions of SNP loci chr3:47120450 and rs769925323 of the SETD2 genes in each sample are read, and the experimental results show that new mutation occurs in two families, as shown in Table 4.
It was found by analysis that SNP chr3:47120450 results in amino acid Asn (N) to Lys (K) at position 1396 in the protein sequence (NP-054878.5), whereas SNP rs769925323 results in amino acid Ile (I) to Val (V) at position 1884 in the protein sequence (NP-054878.5). Since this is a substitution of amino acids of different nature, it results in a severe change in the activity of the protein encoded by the SETD2 gene.
TABLE 1
SNP Base frequency number Total number of bases Homozygote Base frequency CADD
chr3:47120450 0 152312 0 0 23.2
rs769925323 1 152228 0 0.000006569 24.5
TABLE 2
Figure BDA0003440300120000081
TABLE 3 Table 3
Major diagnostics Number of examples
Aortic stenosis, occlusion 3
Common arterial trunk 5
Atrial/ventricular septal defect 12
Pulmonary valve occlusion 18
Right ventricle dual outlet 22
Complete aortic translocation 26
Fallotetrad disease 195
Others 9
TABLE 4 Table 4
Figure BDA0003440300120000082
Figure BDA0003440300120000091
In conclusion, the invention lays a foundation for researching the relationship between the new variation of the SETD2 gene and the congenital heart disease, provides a molecular target for predicting the risk of suffering from the congenital heart disease, and simultaneously provides a theoretical basis for early screening of the congenital heart disease based on the gene.
The foregoing describes specific embodiments of the present invention. It is to be understood that the invention is not limited to the particular embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the claims without affecting the spirit of the invention.
Sequence listing
<110> Shanghai university of transportation
<120> congenital heart disease related SETD2 gene new variation site and application thereof
<130> DD17827
<141> 2021-12-24
<160> 5
<170> SIPOSequenceListing 1.0
<210> 2
<211> 147570
<212> DNA
<213> Homo sapiens
<400> 2
gcgtcgccct gctgcgggga gggggctcgc gtcgccgtct ccagccgctc ccgatgaagc 60
agctgcagcc gcagccgcct ccgaagatgg gggatttcta cgacccggag cacccgaccc 120
ctgagtaagt atcagctccg cggccccccg ctgctgtcgg ccgccttatc cccagccgag 180
ggcggcgcgt cctgacgggt ggcggcgcgg gccggcgcga ggagtaacag gcccacggtg 240
gcctcgcgcg gtcggtgtcg ggagcaggcc cgcgccgcca cttcgagccg cttggccggg 300
gccgcagcag gcccgcggtt gggcccggcg ttggcgccgc tgctcgtgtc gcggcggcgg 360
ttgggccggg ccggtggggg aggggcggcc acggtcccta cggttaccgc cgtgtccgca 420
ccgacccggc catcccgggg ctcggcggtc ctctcgggct cctcgtggct cgtccgggcc 480
ccgctgctag ccaaagggca gagtcggagg agctgccggt gccgggcccg gcaagagggc 540
gccggtgagg gtaggccgcg aatccccggg ctcgggtgga agctcgaccc gtcgcccgac 600
ctccccgcga cggcggcgcc tcggaccgga agggcctagc gcgggttgcc tggcccccgg 660
gccgtggagg ggcccgcgct gcactcctga gtttgatttt ttcctcctgg gaactcgatc 720
ctggccttgc agtgcttccg gattcacatt gtgcaccttt ggcacttggg ttttgtaatg 780
gcgaggtttg tgtggtcccg ttgttgaggt gacaccgggt ttgtttttcc gcttgaaaat 840
gaaagcctcc tgagggacat acattttctt gcaggttgtg agattttcac actttcggac 900
acaattttct tggtaacagg aatctcttac cctaaacgga tgactttcta tttcttgtga 960
agacttggtt aaaaaccaag aatcgtttga ggattctcta aagaagacaa tgttgtggaa 1020
aaccgacaca cagttttgcc caatagtaat ttttcagtct aggacacctt tacatttctc 1080
ttgaggtctg aatctgctgc tgtatctgct atctcagaaa gcctggagtc acttctttcc 1140
ctgaaccctc acgagaccat tgttttgaaa agccgttctt aaacaccgtt tgctggtgtt 1200
agacctagga atatactatt gatttaaaac ttatcggttg ataggggttt cacatgaaac 1260
tgtcaaactt ttatgaccag gatgattcca agagctttgc tgttttgaca cattttacct 1320
taggtttgct ctggctcgtt tttgaatccc ttgccacatc ttctcacatt ggtccagaaa 1380
tgtctggatc ttaattgata gttttgattg caacacaaac ggattctgtt gaggtgttgg 1440
tcatttctgc acaacaagat aaatcattat tttgcttttc taaaaaccca actcttactt 1500
gcaatagtaa gttaacatgg ctttttcctt tcatgggttc ttggccattg gttaacatta 1560
ccttaattag attggtcttt ttgttttgct actggcaggg tcagttaggt aagattgttt 1620
tgatttactg caccatcagt ccaattacaa agctcatgtt ataggttttt agtttgaaaa 1680
acctcaaaaa aaattttata tcacgattca ataaatgctt atatagcact tgctctgtac 1740
aaagtaacat gctaacccct gaataggcta agtgcctgct ttcacttcct tttaccaggt 1800
tgtttggtga agtccggaag ctttaaggat cacatcctta cacttcttgg ggaaaaacaa 1860
tttttcataa tatgtgggaa aatggactca gaagtgcatc tttggtagac ctgagtgggg 1920
aaggaatcaa gaatgtttta tggttttaca tgttttggag tttttatttt tattgcttta 1980
atgtagtaga aatccactgc tttggatttc taacagtgat tatatatttt taaattctcg 2040
tgtatttttt cctttttttt ttttttagag gcagggtccc actctgtcac ccaggctgga 2100
gtgcagtggt gtcatcatgg ctcattgcat ccttgaacct ctgggcttaa gcagtcctcc 2160
tgcctcagcc tcctgggttg ggactatagg catgtgtcac cacacccagc taattaaaaa 2220
aaaataaatt acgttactgg ttttgaatcc ctggcctcaa gtgagcctcc tgccttggcc 2280
tcccaaagtg ctgggattgc aggcatgagc cattgtgcca ggcctcttct tgtgtattaa 2340
cctgtatgga gtaaagaatt gtaacatgtt ttttgttgtt gttgttttgt ttttcctttt 2400
tttcataata ctataaagac tggaggggat catggtaggt atcctgagca atatcacctg 2460
tttggcatat gaagaaaatg aaggctagag aagtgaagtg acagcaaact cttgagatag 2520
taagctagtt agtgtttata atgctagaga gaggagagag aaaggcagta tagggtttaa 2580
aaaacctgga tttcagagtc agacctgaat ctgaacacta ttttaacctt ggacgatgac 2640
ttcatctctc tgaacttggg ttttctcatc ttttatatag gtattataat ggttaacaac 2700
ttactggggc tttttgggag gattgaatga gataatgcat gaagagcact tggcgcagaa 2760
tgtggcacgt gtaagtgctt ctagttgggg tcatcaggga aaagttaaaa ggtaggattt 2820
aagttgagga tgaaaagact aggtgggcaa catggctcag gggagaaatg accaagtgcc 2880
ctttttagac tttggatggt ttgaaatggt acttagacat atgaagaaat tgaggcaaaa 2940
atgtaaattc agtttgactg aagtaacact tagcgtctga tgttctgggt ttgtcttgta 3000
cccatgcttt taatcagaca cagctgcaag atgtcttttt tattcagcag catagaggac 3060
attgtgtttc aggtgaaaat ggctgtaatc acttgagtat ctgtgcagtg ggtgtccatt 3120
atggggcagg cccagggaca ggtgttgagg acacggcaaa gtagatccag ttagtcttta 3180
aggaactctt ttaatgaagg agataggcaa gtactttaca gtgatagagg tgcaggtctt 3240
tgaacatatg catgtctgtt gtatgccaaa cataggcaca ctaagggtaa ttggtgtaca 3300
aaacaaaatt ttgcccttgt ggagtttaca tcctaatagg ggtgataata aatgatatag 3360
aatgttctgg ccaagtgggg tggctttcat cggtaatccc agcacttttg gaggccgagg 3420
tgggtggatc acctgaggtc agtggttgga gaccagcctg gccaagatgg tgaaacctcg 3480
tctctactaa aaatacaaaa aaaaaaaaaa ttagtctggt gtggtggcag gcgcctgtaa 3540
tcccagctac tcgggaggct gaggcaggag aattgcttga acctggaggc ggaggttgcc 3600
gtgagctgag attgtgccac tgcactccag cctgggggac agaaggagat tccatctcga 3660
aaaaaaaata ataaaattaa ataaataatg tagagtgttc aaaggtaagt gctttggaaa 3720
gtggaataga gtaaggggga ttcagaattg ttgaggaaga ggttgcaatt taaagtgagg 3780
tatactgggt gagtatcctt gagagagtga tatttaggaa agatttaaag gagaagtagc 3840
catgttaata actggggtga aggcatttca ataagaggga atagtttcaa ggtgttgagg 3900
cagacctgtg agttttgccc attatggcta gaatggaatg agcaagaagg tgtaataata 3960
aactgggtta gggtgagatg gggtttagct tttttttttt tttggaatgg agtctcactc 4020
tgtcccccag gctggagtgc agtggtgtga tctcggctca ctgcaacctc tgccccctgg 4080
ctttaagcga ttctcctgct tcagcctcct gaatagctgg gattacaggc gcctgccact 4140
gtgcctggct aatttttgtg tttttggtag agatggggtt tcaccttctt ggccacgctg 4200
gtcttgaact cctgacctca tgatccacct gccttggcct cccaaagtgc tgggattaca 4260
ggtgtgagcc actgctctcg gctgaggttt agctttttta cagtcttgta aagccattct 4320
aagaactttg ccaagagttt tgaacagaag agtgacatag tctgctttca gtttcaaagg 4380
atcatttgaa ttgcaaaggg aacaacagtg gaagcctgga gactagtaag gaagctagta 4440
atccagaaaa gagatgctgc cagtaccaag atggtaatat aagagtagtg agaaatggat 4500
ggatactgga tatgttttga agatggaact aatatgacat gtgagagagg aaccaaggat 4560
gattccaggg tttctggtct cagcgttaga aagttgccat caacaaagac agtgatgact 4620
aaaaggagca aatttgagga ctagattagg aggagttcaa ttttaggcat agtaagtttg 4680
agattgcctg ttagatattg agttgatttg ataaccaagt ctgaagttca ggggaaaggt 4740
ctggaatgga gataaatttt gttttcacca gtttaggtat tattcaagcc atgaagctgg 4800
atgagattac cagagaatcc ttggtagaaa gagagaaggg ccaaggattg gtctttttat 4860
ttttttttta agatggaatc ttacattttc cccaggctgg tcttcagcct gggctcaagc 4920
cattctccca cctcagcctc ctgagtagct ggaactatag atgtgtacca ccacacttgg 4980
cttgattggt tttttaaatg cctgtgttaa gagaactgtt ttagtgtgca gtttgaggtt 5040
ttaacatgga tgacatctgt gaacttggga aaattacctc ttcggtaacc tctgactaga 5100
agttagcatt tctttcaatt actaatataa ataacaaact acagtagtat taattgtgat 5160
ttgtgtagaa atcagatatt ttaataataa aatatgcagg tgactcttga tcaaacatgg 5220
gagttagaag taccaatctg caacacagtc aaaaatgtgc atataacttt tgtctccctc 5280
aaaacttaac tgctactagg atactgttga ctttactgag aacatagtct actaacacat 5340
actttgttgt atgttatgtg tattatatac tgtattctta caagaaagta agctagagaa 5400
aagaaaatgt tattaagaaa atcataagga agtgaaaata tattattcat taagtggaag 5460
tggatcatca taaaggtctt catccttgta gtcttcacac tgagtaggct gaggaggaag 5520
aagaggaggg ggttttagtc ttgctgtctt gagtgacaga ggtggaggag gtagaactgg 5580
aggcaggcac aaggtgtgta acttttattg aaaaaaatct gtgtataagt ggacctggac 5640
agttccagcc catgttgttc aaaggcaaac tgtattgtgg tttttataga atcttgaaat 5700
atgtttatca ttatatcaaa atccactaga ttgagaagca catactaagc aatatgacac 5760
attggttttt ttcccctcaa tataattgtc ttcctttgca atcatatgta ttttatctta 5820
tgcattaaaa aatattagac tgagaaggaa tccacaagct tcattagatt gccaaaatgg 5880
tatagggcac aaaaaaagtt aaatccctgg gctctggaga cagaactcct ggtttagaat 5940
ctcatctctt ttacttaatt gctttgtgaa cctaggcaag tttcttaatt actccttacc 6000
tataaagtgg ggatcatggt agtatcatct gcaaagggtt ttatgagaat ttaagaatta 6060
ggacagtgtt agtttctttt ttttttcttt tctttttttt ttttgagatg gagttttgct 6120
cttgttgccc aggctggggt acagtggcgt gatctgggct cactacaacc tctgccccct 6180
gggtttaagc agttctcttg cctcagcctc ccgagtagct gggattacag gcatgcgcca 6240
ccatgcctgt ctacttttgt atttttagta gagatggggt ttctccatgt tggtcaggct 6300
ggtctcgaac tcctgacctc aggtgatcca cccacctggg cttcccaaag tgctgggatt 6360
acaggcatga gccaccacgc ccctggtcag ttcttttatt gttagtattg aatggaacaa 6420
gtcagctaga aagaacggta cttatgaggc gccatgatgt gaaagtatgg caaatttggt 6480
caaaagaaag tttaactggg aaagaatatt tcagcatgtt caaatgagat acaaagcagt 6540
caggatagtc agattctata ttaatttttt atttttaggg acttgttctg ttgtccaggt 6600
tagagtacag tggcaagatt atagctcact gtaactgaac tcctgggctc aagtgattgt 6660
cccatgtatc taggactgca aatgtgcacc accactcctg gctaattttt ttgttttgag 6720
acagggtttc gctcttgccc aggctggagt gcagtggcgc gatgatggct cactgtagcc 6780
tcaacttccc aggctcaggt gattctctca cttcagcctt ctgagtagcg gggactgtgg 6840
gcacatgcca ccatgcccaa ctaattttgt ttgtagagat ggggtttcac catgttgccc 6900
aggctggtct caaactccta agcccaagtg atcttcctgc ttcggcttcc caaaagtgct 6960
gggattatag tcgtgagcca ctgcacctgg ccctggctaa ttttttattt tttatagaga 7020
cagggttttg gtgtgttgcc caggctggtc tcgaactcct gtccttggcc tcccaaagtg 7080
ctgggattac agatgtgagc caccgtgccc agcaagtcaa attcttataa ttcatgttag 7140
aatggagaag atagagatac cttaggaagc caactgagag aaagtatcat gtggttacca 7200
gatttcatat ataatctgga cctttagtag ctttatagac agttgaatcc atttttctga 7260
tgagagagag agctttgtag tgatggaggt atggtgctac aggccaggtt accttctttg 7320
ggctactgag atgcacagga ggccagtata gtacttggag ggtttgctgg taagtatgga 7380
aagcctgttg aactatccta gtgcttaggc tagggtatac ctctttaata ttcatgtccc 7440
tctttgccat ttgcttttgc tacattttag gcataccatt ctccttttat tgacacatta 7500
tgtctttaga aaagtatcaa gcaactgttg atacaactgt gttttcctaa gaattgtctc 7560
tagttgccaa gccgtatttt atacatacaa gattatctat cagtcatact ttcctagttt 7620
ccttagcagg actttggtgt ttccagatct tctcagtcat ttttcactgt agtgactcgt 7680
tgatttaatt tattcactta aaaattttgt ttaatacatt acagtttatt ctgtaataga 7740
tatttgtaat aaattttctc aaccctaata ttcattgttc catgagcatt gtcaggtttt 7800
ggatggaagc aggatggcca gcctgggttt gagaatcaaa agttgaccag cttctctgtc 7860
cataaatcta ttacgtggct ctgctggagc ctctctgaac ctatcctggt taagaggctg 7920
ctcaatttgc taattgttct ttgctcagtt tcttaaaaaa gttgactagc ttcatttctg 7980
ttaattcttc caagagtacc gtagagtact tgattttgta atacactaag aactattatt 8040
gtaaaaccct gagagatagt ttatattgga aactaagcca tttacaccta agtcactgaa 8100
atcaggttag aatgtttttc tgacagaaaa aaaaaacaac aaaaacaaaa aaacactttt 8160
ttatgtgtgt gtgagacagg gtctcactct gtcacccagg ctggagtgca gtggcacaat 8220
cttggctcac tgcaacctct gcctctgagg ctcaagcgat cctcccacct cagtgtcctg 8280
agtagatagg actacaggtg cacactacca cacccggcta atttttgtat tttttgaaga 8340
gatggggttt gccatgctgc ccaggctggt tttctgacct caagtgatcc acccacctca 8400
gtctcccaaa gtgctgggat tacaggtgtg agccactgcg cctgtcagaa aacacttttt 8460
attttgaaaa aattttaaac tttcaggaaa gttgcaagaa tagcacagtg aattcccata 8520
atgtactttt aacctagatt aaccagtaat tggaattttg ccacgtttgt attacctttc 8580
tatattttaa aaaaagtttt atttactttt ggcagaacct tttgagagta aattgcaggc 8640
atcatgatct ttctttccta aatatctgat agtgttacct aagaacaagt attgtcttag 8700
ataatcaata tacagtaatc aaattcagac attttaacat ttgtaaccct actattacct 8760
gatatgtaat ttatacattt tgccagttgt cccaaagatg tctttttttt tcaatctagt 8820
attacacatt gcatttaatt gtcatgtctc ttagtctttt tcaatctctg aggataactt 8880
taaatttgtt ttggaagtac tttattacta tgtactaacc atgaatgtga tattttaaaa 8940
acaataacag ggtctgatag tatgtttaag attttttttt ttttgagatg gagtcttgct 9000
ctgtcgccca ggctggagtg cggtggtgcg atctcggctc actgcaagct ccgcctcctg 9060
ggctcacgcc attctcctgc ctcagcctcc ggagtagctg ggactacagg cgcccgccac 9120
cacgcccagc taattttttg tattttttta gtagagatgg gtttcaccat gttagccagg 9180
atggtctcga tctcctgacc ttgtgatccg tccgtctcag cctcccaaag tgttgggatt 9240
acaggcctga gccaccgcgc ccggccaatg ttttgttttt ttaattacca caacaataaa 9300
tgcttattgc aaaagggtca gacaatacaa atgtttatag aagaaaaagt aaaaatcctc 9360
cctgagtatc tcttctctgc tccacctctc caaataccat atccaagaac ttaatgtatt 9420
tttcgagatc ttttcctttt tttggttttt atttttttac acaaatggag tcatattact 9480
gtatgtattt ttctgccttt ttcctacatt ctgtatttgt ttccatttac atataagata 9540
tgcttatctt tctttctttc tttctttttg atatggagtc tcgctctctt gcccaggctg 9600
gagtgcagtg gcacaatctc ggctcactgc aacctttgcc tcctggattc aagcgattct 9660
cctgcctcag cctcccaagt agctgggact acaggcgcgc accaccacgc ccagctaatt 9720
tttatatttt tagtagagac ggggtttcac catgttggcc aggatggtct ccattttttg 9780
acctcatgat ccgccctcct tggcctccca aagtgctggg ataacaggtg tgagccatcg 9840
cgcctggcca agacgtgctt atttttttaa atagttgaac aatattctgt agtatggatg 9900
taccatgtta agttgtttga ttttcttaag atgtctggtt agtatattag gcagtttaaa 9960
agagccttag ggcatattgt gctacgtgga aggtgtctct ttccaaatgt atttctccac 10020
agagtgagtt tttctggtta tgatggtgtt tgggggattt tgtttagagt tttttaaaaa 10080
atctgtactt atttctattt gtatatggta ctgatggatt aagcagataa tttttattcc 10140
tgccttactt tgattagtta cttgtttctt ttaaaaagga aactgaaggc atttaagtgg 10200
gatctctttt tttttttttc ttttttggat cagggcctcc cttgtcacct aggctggagt 10260
gcagtggtat gatcccagtt cactgtagcc tcgaactctt gggctcaagc aatcctcctg 10320
cctcagcctc ccaagtagct gggacaacag gcatgcgcca ccacacctag ctaattttta 10380
aatttttttt gtagagatag gagtcttact atgttgccca agctggtctc aaactcctgg 10440
cttcaaggaa tcctcccacc tcggcctccc aaagcactgg aattacagtg ctgggcaccc 10500
ctgtgcctgg ccttaagtgg ggagtctctt gaaaatggtt ggtttgaggc tggccaacag 10560
agctaagaca aaatttgata ggtttgttgt tgtcattttt ccatagttgg acttatacag 10620
tatttggaag tctctcattc aaatgaaagg caattacctt gtataatttt tggttaatta 10680
ccttgtataa tttttggtta ataaaaattg tgtaataaaa tgttgtattt gagtctctta 10740
gctttggaat ttgtgtaaat ttactttgtt taatttggta gtctttgctt tttaattttt 10800
taattttaaa aattagataa tcacttcact gggtctcacc tcactgccca ggctggtctt 10860
gaactcttgg tctcaagtga tcctcctgcc tcagctttcc aaagtgctgg gattacaggc 10920
gtgagccacc atgcctgttt tttgtgtttt tggtcaagct aatggttact tcagtctttt 10980
ttccagctga gcaaacatat tgtcatttca atggaggttt aagataggtc tgaattccca 11040
tagttgcttt ttattttaga atgctttttc tgtcaaatgc taacatcttg caagtgaaaa 11100
tatccttggg atgatgtggg tgttgataag actgcaattg tgctggcagg cttctgggag 11160
gtctgcttac tgggagcact gctctgggct tgcaagaacc tagagcaagt ggtggtttcc 11220
aattgtagtt cttcctgtgg cccacttccc tgccaagtgt ggttggaccc tctctttggg 11280
gaggactatt atcgtaatca acactatttg cttcatggtt agctctttgt gaatccgtgg 11340
tctaacttgt gttttgaggc ttttgtctga tatttggcct catgatgaat agttattaat 11400
tacatactct atttgaagaa gcagaagatg ctaggtttaa agtttaaatt ttttatgagt 11460
tttgtgtgaa tgtaaagtgg agcaaatact gtttttcaca aattatatta aatgactgta 11520
aaaactcttt ctatagaaat ccatttattc tggccttgag cacacacaga cctggttgaa 11580
aatacatctg gttaaaaatt gcctggttaa aaatacgact cttccattaa tttatcaata 11640
cttgattgga gtatcaactc taaaacataa gctacacatt ttatggtact ggttctgtgc 11700
tgaaaatgta gttaagaatt atctgtagta aaggcaaatt tctttgaggt acaatacaac 11760
attttagaaa ttggtgaaaa tctcttcaag tttgcctcaa ggtaaccata ataggtatat 11820
tttcaagctt aagcttacca tgtctattga ggaacaaaaa caaaacaact tttgttgtac 11880
aattattcag gaaaccagtt gtcacaatta tgaaaagtat agtatacttt ttggcagatt 11940
agcagtttgt gtaaggaagt agtgttacta gctgatatga acaccttgaa cacattcaaa 12000
ccgtagtgat tgaatataaa aagactgttc ccccaattat agtattgctc atatgaatta 12060
gggagatgat gagatttgca agaagtattt ggtgctcttc cttctttgac tacctatttt 12120
ctttccaaac tttttttttt tttttttttt gagacaagag tcttggtctc tctcccaggc 12180
tggagtgcag tggtgcgatc ttggctctct gcaacctccg cttcccgggt tcaagtaatt 12240
ctcctgcctc agcctcccaa gtaggtggga ttacaggcgc gtaccaccac gcccggctaa 12300
tttttgtgtt ttagcagaga tggagtttca ctatgttggc taggctggtc tcgaactccc 12360
gatctcaggt gatccacccg ccttggcctc cccacatgct gggattatag acatgagcca 12420
ctgtacgcgg catgctctta gagaagatca tgatggtgtc aggatatgaa actgggagca 12480
ggagttagaa tctgtgatag gacttttttt ccagttgtgc gtatgtgtgc tgcacaattt 12540
ttttgttagc tgtgtgcttt tttgaaatgt accgattgct taagcttttt tattttcatc 12600
gatgctattt tttcatataa gtttttaaaa gatatgtttt tatatatgta tttttataat 12660
tctgtaattt ttaagatgtt ttggttgatt attaatacga agtttcaaga aaggctaaca 12720
tttcattgaa gcctggctat cttagcattc atctattctc attagacctg tttggttttg 12780
ttgctaggac ctaagggatt ttgtagatct atgtatcaga aaattcaaga cccatgatga 12840
atatattata gaatatgttc ttctctttta atggaggaat cctagtaact agtagttggg 12900
tacatggtag tacatgctta gtaaatgttt gaattgacct gattctttgt aacgatcatt 12960
attctaattt gattaccagc agcattgtta ataattgctg acctctatta taatacatgc 13020
ttttcttttt tctttttctt tctttttttt tttttttaaa gatagggtct ttctctgtca 13080
ctcaggctga aatgtagtgg cacgatcacg gctcactgca gcctcaacct cccaggctca 13140
agaaatcctc ccactacgcc taattttatt tatttatttt ttgtagcgac agggtctcga 13200
actcctggac tcaggcagtc tccctacctc agcttcccaa agtgctggga ttacaggcgt 13260
gagacaccgt gcccagccta ttaccagaca ttcttaaata actataagat taggacagag 13320
gtcagggaat tgagtggtat gtgttgggct aatggcagtg acttggtgct catagcactt 13380
tttatgcttc ttctgttggt atgctagacc acttttttct cccagccttt tcagttgttt 13440
tgtacttgtg tattttccag gatgggtaat ccttaaacta agggtaagct gcactttacc 13500
cttgttctgt tgactttcta tccaaatttc tcagatcagt aatctcattt atctctttat 13560
aaatattatg ggcaaaatat tacgggcaaa aaggaagtga ggaacctcag atgcagtggt 13620
aaatcaaacg atatttttga ggccgcgcac ggtggctcat tcttgtaatc ccagcacttt 13680
gggaggccga ggcgggcgaa tcacaaggtc aggagatcga gaccatcctg gccaacgtgg 13740
tgaaacccca tctctactaa aatacaaaag ataaattaaa attagccggg cgtggtggca 13800
ggtgcctgga gtcccagcta ctcaggaggc tgaggcaggg gaattgcttg aacccaggag 13860
gcagaggttg tagtgagccg agattgcgcc actgcactcc agcctggcaa cagagcgaga 13920
ctctgtctca aaaaaaaaaa aaaaaaaaag tatttttgga tatgccaaaa gacactgaaa 13980
aatgatagaa aatttagtac tccaaaaata gaggcttttg ttcttctcta gggtagctga 14040
tactttttat acctagcata caaaaaaatt cagttttcta aagtctgtca gtttctaact 14100
gtatgaggca attaaaaacg ttatatttaa actcttttca ttatatcgag ccttttaacc 14160
taatgtttag aacaactagc tgagattgaa ctcttgaact cttgacaatt tattcagcta 14220
acatttgttg aatgccagac ctgtgctaag gatacagaag taagcacaat gtgctatggc 14280
agggatatct gacttctact gggatgggga tcaggtgggc aatcagggag ggcagcccag 14340
aagaatacct gaacttagcc ttgaagagta ggacttaggc aaaaatggag taggcagatg 14400
gtagaggatg ttgtagggct acattatggg ggaggataca gagagaggat gaaccctatg 14460
cccatttccc cttcagtttt taaccaagtg taaattgctg agtgctataa gaggtgtcta 14520
gtgtagggag tccttctact atatctaata attcctcatt tctgtggctc ccaacttttt 14580
ttttttcccc tttagcttgc tcattgtgac ttgccatgag tgtgatttta aaagggcaag 14640
gggagctagt gcctctaatt ttataaaggg aagaaaagga agtccaaaga catacaggtt 14700
gtgctcacta gctagtttag tggcatatca gaacttgggt aatattcatt taccagtttg 14760
tccaaaactg actttttaat gatgttaagg aataacattt agaatagctg ccattcataa 14820
acaactggat ttctgtattg agttacttgt tttcctaaag gtcttcagaa ttgaccttga 14880
tgtacttata attgttcaat ttggagggtg caggtgattc tgtatttgaa ttggttcttt 14940
cctctgactt tgcaaatgta tatgctggag gattatgggt atgaatatca ttcagcaaaa 15000
ggtaaactgg atatggggat cattcagatc tgcccgtttt tctgtccagg tgccttaagt 15060
agtctgaaat ctttactgga aatgagctta atcccgtatg aaactcaagc cttcattcac 15120
cattattcca tgtagtgatc ctcccgcctc agcctcccaa agtgctggga ttacaggcgt 15180
gagccaccgt gcctggccta tggccacttt taaaaaagaa acttgtatgt aagtcgattg 15240
gatgtctata aagtttttcc tactggaaaa tggggttttt attattctaa cctcagttct 15300
aagtcaaaca tcattaattt aagaccctaa ttaatgattg tctgattcag aaatgtgcat 15360
ttatttgaag ttcatttaaa aaccagtgct cattttagaa tagtatagag gtagaaagaa 15420
ggtataaaaa attggagaat acttgaacac agattgtact ttgaaatttc cctgtttttg 15480
tattttttgt cttcattaaa agaaagtttg aggggagtaa cattgttctg tttcaataaa 15540
gtttcagggc caggcacagt ggctcatgtc tgtaatccga gcactttggg aggctgaggt 15600
gggcggatcc cctgaggtca ggagtttggg accagcctgg gcaacatggc aaaaccctgt 15660
ctctactaaa aatacaaaaa ttagcccggc gtggcagtgg gtgcctgtaa tcccaactac 15720
ttgggaggct gaggcaggag aattgtttga acccaggagg cagaggttgc agtgagctga 15780
gatcgcgcca ctgcaatcca gcctgggtga cagaacgaga cgctttatca aaaacaacaa 15840
caacaacaac aacaacaaca acaacaaaac acaaccaaaa aaacaagttt cagttggtta 15900
tgttatagtt gaagcctagg tttactaaaa tatattttta gcccaccaat gagtataata 15960
ctttaatttt gtaagagggt tctaagcata cctttatgaa caagagtgca gaaagtatag 16020
gagctgaaag aaaatatctt tttttttttt tttttttttt gagacagagt cttgctctgt 16080
cgcccaggct ggcgtgcagt ggtgtttgct cactgcaagc tccgcctccc gggttcatgc 16140
cattctcctg cttcagcctc ccaagtagct gggactacag gcgcccacca ccttgcccgg 16200
ctaatttttt ttgtattttt agtagagaca gggtttcact gtgttagcca ggatggtctc 16260
gatctcctga ccgtaatctg cccgccttgg cctcccaaag tgctgggatt acaggagtga 16320
gccaccgcgc ccggcctaga aactatctta aaaaatgaca tgctggctgg gcacagtggc 16380
tcacacctgt aatcccagca ctttgggagg ctgaggcagg tggatcacct gacatcagga 16440
gttccagacc agcctggtga aaccctgtct ctactaaaaa tacaacaatt agctgggcgt 16500
ggtggtgcat gcctgtagtc ccagctagtc gggcggctga ggcaggagaa tcgttcgaac 16560
cgaggaggca gaggttgtag tgagccaaga tcacgtcact gcactccatc ctgggcgaca 16620
gggtgagact atgtctcaaa aaaaaaaaaa aaaatgacat gcagtggcta ggcttggtgg 16680
ctcacgcctg taatcccagc actttgggag gctgaggagg gcagatcacc tgaggtcagg 16740
aattcgagac cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaaaa 16800
attagcgggt gtggtggcga gttcctgtaa tcccagctac ttgggaggct gaggcaggag 16860
aattgcttga acctgggagg cagaggttgc agtgagctga gattgcacca ctgcacttca 16920
gcctgggcaa cagagtgaga ccctgtctca aacaaacaaa aacaaatatg ttacagctct 16980
catttattga gtataaactc tctgccaggc actatatgaa ggaatttttt tttttttttg 17040
aagacagggt ctcactctgt cacctagagt ggactagtaa tgcaaacctg gctcactgca 17100
gttttgactt cctggactct caagtgattc tcctgtctca gcctcccaag cagctgggac 17160
cacaggcaaa cgccagtata cctggataat tctaaaattt ttttgtagag gcaagatctc 17220
tccatgttgc ccgggctggt tttgaactcc tggcttcaag cagtcatctc gccttggcct 17280
cttagaatgc tgggattaca ggcatgtgcc atcatgcctg gcctatatga aggaattttt 17340
tttttttttt ttagacggag tctcactgtg tcgcccaggt tggagagtag tggcatgacc 17400
tcggcttact gcaacctctg cctctggatt caagcgattc tcctgcctca gcctcccgag 17460
tagctggtat tagaggcgac taccactatg actggttaat ttttgtattt ttagtagaga 17520
cggggtttcg ctatgttggc caggctggtc ttgaactcct gacctcaggt gatccgcctg 17580
cctcggcctc ccaaagtgtg ggaattacag gcgtgagcca ccacacccgg ctatatgaag 17640
gattttaaat agacactcgt tctcttttta aagtaaatat agtactattt cagttttata 17700
gctagcttct ttggcctcca tttcttttag taacttaggt taaaaaactt tggagtcagt 17760
attcaaattc aggttgactg aatataagag cttttgctcc taatatattg tactgtgggt 17820
ggtacctctc cagctgacat tttgagagta caagatggga gataagagca agtgggatat 17880
gctttctgga cagaggcact agaaagacca tagcagacaa tttaggctgt atagcttttt 17940
tttttttttt tttttttttt ttgagacagg gtctcgctct gtcacccagg ctgaagtgca 18000
gtggcaccat catagctcac tgtagcctta gactcctggg ctcaactgat cctcctgcct 18060
cagcctcttg agtatctggg actatagatg taagccacta tacccagcta attttttatt 18120
ttttgtagag acagagcctc gctatgttgt ccaggccagt ctcaaattcc tggccttaag 18180
cactcctcct gttgggggcc tcccaaagtg ctgagactac aggcatgagc caccacacct 18240
gttcagctgc atagttcctt ttaggttata tagttcttaa actgtataca ggcctcagct 18300
gaatccaaaa atgtgaaatc tgaaatgctc caaaagttaa aactttttta atgctgacat 18360
gatgccacag tgggaaattt tacacatgac ctgatgtgag gggctgcagt caaaacacag 18420
ccaagctggg catggtggca tgcacctgta gtcccttcag gagcctgagg taggaggatc 18480
atttgagtcc aggagttcaa ggctgcagca agctgggatt gtactactgt acttgctcca 18540
gcctgggcaa caaagcaaga ccccgtctct taaaaacaaa aacaaaacac aggcatacaa 18600
cacagtttat tccatgtccc aaaattatta aaaaatattg tataaaatta ccttcaggcc 18660
atgtgtataa ggggtatatg aaacataaac aaatttggtg tgtagacttg ggtccaagat 18720
atctggcccc aagatatctc gtgtatatgc agatattcca gaatctgaaa aagttggaca 18780
tacttactgt cccaagtgtt ttcagtaagc gttactcaac ctgcagtttt tttcatcatt 18840
ctagttatgt ttacacattg tcagttttga tttttcagtg ttctcacctc tgtagatgta 18900
ggcatgaaaa ccagctgcgt actttaactt ttggatataa tattgtctac tatttaattc 18960
caagccatat tctgttattt ttaaaatatt tatttattgt ttgtttgttt gattgattga 19020
ttgtttttga gacagagtct cacttgtcgc ccaggctgga gtgcagtggt gtgatctcag 19080
ctcactgcag cctcagcttc ccgggttcaa gcgattctcg tacctcagcc tcccgagtag 19140
ctgggattac gggtgtgtgc ccatctaatt tttgtatttt ttgtagacat ggggttttaa 19200
ccacgttggc atgaactact ggcctcaagt gatccacccg cctcgacctc ccaaagtgct 19260
gggattacag gtgtgggcca ccgtgcctgg ccttatttct ttttctggac ttacttattt 19320
tttattttta tattttgaga cggagtctcg ctctgtcacc aggctggagt gcagtggtgc 19380
gaactcggct cagtgcaacc tctgactccc tggttcaagc gattctcctg cctcagtttc 19440
ccaagtggct gagactggga ctataggcat gcaccaccac gcctagctaa tttttgtatt 19500
tttagcagag acggggtttc accatgttgg ccaggatggt ctcgctctct tgacctcgtg 19560
attcgcctgc ctcggtctcc caaagtgctg ggattacagg catgagccac tgcacccggc 19620
tggacttatt tatttttata atttttttta gagacagggt ctcacagtgc tgcccaggct 19680
ggtcttgaac tcctgggctc aagtgatcct cctgccttgg cctcccaaaa tgttgggatt 19740
acaggtgtga gtcactgcac ctggcttctg atattttgcc ctgtgttgtt tctgtgaggt 19800
atacatttac tttgtcagct tggagtagtt ctttgtcata gagcataaga tttggcctcc 19860
tcaagtgagc tgtttatagc acttaagttt tgtctctgat taagtggcta gaaacttgac 19920
agctagagct gtgggacaac tgcattttct taagttctgg tgtaatgtgg ccgggcgcag 19980
tggctcatgc ctgtaatccc ggcactttgg gaggccgagg cgggcagatc acgaggtcag 20040
gagatcggga ccatcctggc taacacggtg aaaccccgtc tctactaaaa gtacaaaaaa 20100
ttagccgggt gtggtggtgg gtgtctgtag tcccagctac tcgggaggct gaggcaggag 20160
aatggcatga acccgggagg tggaggttgc agtgagccga gatcgcgcca ctgcactcca 20220
gcctgggcga cagcgagact ccgtctcaaa ataaaaaaaa aaagttctgg tataatgtaa 20280
cttgacattt gagatataaa accaatggga taaagttctg ataaaagttt gttttataga 20340
tcaactagct ttattatatg aatatgcagt tatatactgt tagtatttaa taatgagcaa 20400
cttacagaaa ttaaaaagat cagtagacta gatagcaatt ctaatctgca aaatgatgtt 20460
caaaaatact cttatttttc tgtttacctt aagagcacaa aagatatttt ttgcaggaaa 20520
tgaaaattta gcactgtagt gccttatcct aaaagattac agataggtgg aaagtggatt 20580
taaatatttg gaatattagt gtttctctcc ttgaacacag cagaatttta tgtctacttt 20640
tgttaaggtt ttttccccaa taaagttttt ttgttttgtt ttttgagacg gggtcttgct 20700
ctgttgctca cggtggaatg cagtggtgag atcgtagctc actgcatcct tgacgtcctg 20760
ggctcaagca gtggtcctgc ctcatcctgc tgagtacctg ggactacagg catgcatcac 20820
caacgcctgg ctaattttta aattttttgt agaaatgggc tctcactatg ttgcccagac 20880
tagtcttgag ctccttgggc tcaagtgatc ctccagcatc agcctcccaa agtgctggga 20940
ttacaggtgt gacccaccat gcccagcccc aactttcatt tttccatttt gaaaataaga 21000
agccaatgag ccaggcgcag tggctcacgc ctgtaatccc agcactttgg gaggctgagg 21060
tggggcagat cacctgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc 21120
atctctgcta aaaatacaaa aaatcagttg ggcgtggtgg caggctcctg taatcccagc 21180
tactcagaag gctgaggcag gagaattgct tgaacctggg aggcggaggt tgcagtgagc 21240
gagattgcgc cattgcactc cagcctggcc gacaagggca aaactccatc tcaaaaaaaa 21300
aaaaaaagac aatgtatata tggtattccc cttccccacc tccccccacc acgaagtagc 21360
atactaaatt tactgttttg tttcttgctt tttttcctta acagtacatt ccggagcagt 21420
atacagagat cttcattatg accttttatt ttaattaaat taattaatta acttagattc 21480
ttgctctgtc acccaggctg gagtgcagtg gcaccatgtc atctcactgc acccttggcc 21540
tctggggctc aagcagtctt ctcacctcag cctcctgagt agctgggact acaggcgcac 21600
accatcacac ctggctaatt ttgcttattt tttgtagagg cgaggtctca ctatgttgct 21660
caggatggtc tcgaactcct agcctcaaac aaccctactg cctcagcctc ccaaagtgct 21720
gggattacag atgggggagc taccacgtcc agcccattat tatgatcttt tagatcaaag 21780
ttcgtaatta gaactttttg aagctgcata ctaccacatt gaacggatgt accagggtta 21840
ttcagtcact gttacaacct tttactagca cacagatagc cttttgcagt ttattttaac 21900
ctttttctgt atgaaatgat ggatagtggt gcattcagtg cattgtaatt cacaatcatc 21960
ctatattatc atttggcttt gccttgtaag aatatgtgtt tcaagtgttt tttttaaggt 22020
atggatagct tttaccctac ttgtagttgt gttagttgac ttgaaacctt ttccttctat 22080
acctcagaca ttaattacaa tgaaaaaaaa atgcttaaac tctttaccaa aaccagaaaa 22140
taaacaatgg ctatttttat tgcatttaag cttttgttcc gtaagagtac tgaattgttt 22200
tttaatgtgt tttgattttg gtcgggtggt aacttatgct agaaactttt tgaattgttg 22260
tacttggtat gtttctaaaa tagaaagcag cccacacatt tttttatttt ttctttataa 22320
caaaagaaaa cttacttgtg aaacatgaaa taataaaatt attttcagaa gcatttttag 22380
tattaagatg aaagtaagca gttatttatg atggaaagag atctgaaata tgtataaaaa 22440
gagagacctt gtctttctca tgtctttcca tttaatcaca tcacaggttt tatttctgtg 22500
tttttattta gaaggtgggt ttttcagagc taatttgcat gaaaggctgt aacttgaaag 22560
agctgttttt gtattctcat ttaatgtggt taagcaagag taggacagga aggctgacat 22620
aagtacttag tctggtacaa tacaagatag gtacagttta aacattaacc aactgggtgc 22680
agtggctcat gcttgtaatc ccagcacttt gggaggctga ggcaggcaga tcgcttgagc 22740
ccaggagttt gagaccagcc tgggcaacat ggtgaaaccc catccctact aaaaattcaa 22800
aaattagcca ggcatggtgg tgtgtgccta taatcctagc tacttgggag gctgaggtgg 22860
gaggatcact agaatggggc gggggtgggt ggtgtgaggt tgcagtgaac caagatcatg 22920
acactgcact ccagcctggg tgagggcagt gagatcctgt ctcacaaaaa aacaatatta 22980
accaagcgag cttagagtct acagtctaat tataatagtc taattataac aagccatctc 23040
cctcagaaac ctatctcatg tctttcttcg tattcgatac ttagaatttt taattttaat 23100
tttaattttt tatttgagac agagtctcgc tgtgtcaccc aggctggagt gcaatggcgc 23160
aatctcagct cactgcaacc tccaccccac tgggattcaa gtaattcttg tgccttagcc 23220
tcccgagtag ctgggattac agatgactgc caccatgcct ggctaatttt tgtattttta 23280
gtagagacag gatttcacca tgttggccag gctgatcttg aactcctgac ctcaagtgat 23340
ccacccgcct tggcctccca aagtgctgag attacaggcg tgagccactg cacctggcca 23400
gtcaactctt tctgtgtgat tcactggctt gtactaaaga tgaatttcag catttatgca 23460
tatttatctt ttgaggctta tttggtattg gaggttttcc tctctcactt tttgctaatg 23520
aggaaaacaa atggataatt gaaaagatta actcagagta atgagtaaaa ttactggaat 23580
tcaattgaat acaatagtct tcaacactgg gctctaaaat gttcaggtta ggtcacccaa 23640
cgttccaact tatgggtttt ggaaaaagca gatggcttta acaggtgaat atcattcact 23700
ttaggtaggt attcttgtgt atctatttgg cagacaagta gagaaacatt tcaggcataa 23760
atacagttgt taacatttgg gattatagtc ttaacctttc ctcactgatt agaattccgt 23820
agtgacacat ttgagattag ctttttaaca aagtcacttc ttgttagaag tgactttttt 23880
aaagaaaata agttagcttt actcacttgt gtagtaattc cacattaaaa taaagtttca 23940
gctatttttg gggtgtaaga atagttggtg agtatgatca agttattttt ttctagattt 24000
agtcggtata tattgatcaa taggattctt tgtatgtttg agatactata ccagttgaag 24060
atgtggactt aaacaagtga gaaggagtgc ttgtatatca agtctactca tgctagttca 24120
ggttagcata cttactccaa agtgctttac ctgaaatttc aatgtctttg ataaagcagt 24180
gtatcactca tagctttatt gaccacataa ataacgtata tttttcatca gtgttttttt 24240
ttaattcact tgtcttcacg tgtccttgtt cttagatgag aatgcggcaa atttcataaa 24300
ttttatggcc tatatatctt gctttttcta catgtcagtt ttgagatgtt tccctctttt 24360
cctttaagaa ttgcttgaag tgaggaagct aaaaactagt actgttgtta aggagtttct 24420
ttgattcaaa aagtaacgag aatgtatgat aggaacggga atgttaggcc caggggagat 24480
tatataataa ggacaagatg ttgcctttgt ctctttgaaa tttaaactct atatggggag 24540
acaagaacaa taaatgcaag tcaaggctgt atgtgattgt cagattgtaa agtatatgct 24600
gtaggagttg aatttagtag tagtatctgg aaaggtaaga aaaggatagg aaaaggcata 24660
atagtgctga gtacctacta gacattcaga taattgtcaa aggaaggaaa ggctttagtg 24720
gtccctgagt ggattaaggt agatatgggg gtgatgtggt atgtgtgtag tgtggaggct 24780
gagagggagg aaggtgatga aacgagcaat acaaaaaata atttgagagc ttgggcaaga 24840
taagtgagcc cgtctctata aaaagttaaa gaaaattagc cagctgagga gacttgggag 24900
ggaggattgc ttgaacccag gagttcgagg ctgcaatgag ctatgatcgt gccatagcac 24960
tccagcctag actctgggtg acagtgggta acagagcaag accctgtcaa aaaaaagaaa 25020
agaaagaaag acgttgaaca agactgatct agatttgaac ttaaaagaga ccaccatagc 25080
tattgagatt ccttctgggg agtagtgtaa aagcagctta actaggtagg aaaatgataa 25140
tcccagcact ttgggaggct gaggtgggca gatcacttga gaccaggaat ttgagaccag 25200
cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc caggcttgac 25260
tgggcgcggt ggctcacgcc tgtaatccta gcactttggg aggccaaggt gggtgaatca 25320
ccagagtttg ggagttcaag accagcctga ccaacatgga gaaacctcat ctctactaaa 25380
aatacaaaat tagccaggct tgatggtaca tgcctgtaat cccagctagt tgggaggctg 25440
aggcaggaga atcacttgaa cctgggaggt ggaggttgtg gtgagccgag atcatgccat 25500
tgcacttcag cctgggcaac aagagtgaaa tttcatctca aaatataata ataataataa 25560
cacctgtaat cccagctata catgggaggc tgaggcagga gattcgcttg aacccaggag 25620
gtggaggttg cagtgagctg agatcgcgcc actgtactcc agcctgggcg acagagtgag 25680
acttggtttc aaaaaaaaag aaagtgggcc gggcgcggtg gctcacgcct gtaatcccag 25740
cactttggga ggctgaggcg ggcggatcac gaggtcagga gatcgagacc atcctggctg 25800
acacggtgaa accccgtctc tactgaaaat acaaaaaaat tagccaggcg tggcggcggg 25860
cgcctgtagt cccagctact cgggaggctg aggcaggaga atggcgtgaa cccgggaggc 25920
ggagcttgca gtgagccgag atcgcgccac tgcactccag cctgggcgac agagcgagac 25980
tccgtctcaa aaaaaaaaga aagtgataat actgtaatcc cagtactttg ggacactgag 26040
gcgggtggat cacctgaggt caggagttcg agaccagcct ggtcaacttg gcaaaacccc 26100
atctctacta aaaaaaaaat aaaattagct gggtgtggtg gcgggtgcct gtaatctcag 26160
ttacttggga ggatgaggca ggagaattgc ttgaacctgg gaggcagagg ttgcagtgag 26220
ccaagatcgc actattgcac tccagcctgg gcgacagcaa gattctgtct cagaaaaaaa 26280
gaaaaattta taataatgtc agatatttat tgagtgctcc atatcttcta agtggtgttt 26340
ttggcagtta aatgcagctg taaacaagat aaaaccaaat ctctgtccta aagaagcttg 26400
tatgctagtg ggaggaaatg ggcattacat aaaatattta taaataaaaa ataaacaacc 26460
aactcttata gtaataaata ctaggaaggc tgggcgcggt ggctcacacc tacaatccca 26520
gcactttggg tggctgaggt gggtggatca caaggtcaag agatcgagac catcctggcc 26580
aacatggtga aaccccatct ctactaaaaa tacaaaaatt agctgggtgt ggtggtgctt 26640
gcctgtagtc tcagctactc gggaagctga ggcaggagaa tcgcttgaac ccaggaagtg 26700
gagtttgcag tgagtcgaga tcacgctact gcaatccagc ctggcgacag agtaagaccc 26760
catctcaaaa ataaaaataa aataaaataa aaataataat aaatgctagg aataaaataa 26820
ggtactataa tatagaatga tgggagaatc tcaaaggaaa taacatttga ggtgtcatct 26880
ttttaaaaaa attattttag attcaaaggg tacatgtgca tgtttgttac acgtgtatgt 26940
tgcatgttgg tggggattgg gcttctagtg tgcccattac ccaaatagta gtgaacattg 27000
tactcactag gtaatccttt tttttagatg gattcttgct ctgttgccca ggctggagtg 27060
cagtggcgtc atctcggcac actgcaacct ctgcctcccg ggttcaagtg attcttctgc 27120
ctcagcctcc caagtaggtg ggattacagg cacccgctat catgcccagc taatttttgt 27180
atttttggta gagacggggt tttgacatgt tggccaggct ggtctggaac tcctgacctc 27240
aggtgatcca cctatcttgg cctcccaaag tgctgggatt acaagcgtga gccacggcac 27300
ccagccccca ttaggtaatt tttcaaccca ctgccctatc ttttggagcc ccaagtgtta 27360
attatttcct tctttatgtc catgtgtacc cattgtttag ctcccactta caagtgagaa 27420
catttagtat ttggtctttt gtttctgagt tagttcacta aggataatgg cctccagctc 27480
catacatgtt gctgcaaaca acatgatttc attcattttt atggctgtgt gagatgtcat 27540
tttattatcg agaagcagca gtctggtgaa gatctggagg gaatggtatt ccaagaagga 27600
acaagcaggt gaaagggctg tgagccagaa attatcttgg aatgtatgag ggacagagag 27660
aaggctaatg tggctaaaac ctagagaatg aggaggaggg actatggaaa gaggtaaggt 27720
cagaaagagg ataagcaggt atgtggagtg ggctgtgagt ggagagagaa aaattaagga 27780
caaatgaggt ttgatctgag caattgggta gatggtagta ttactgtcat aggaacgact 27840
tgggggagga ctgaattagg tatatgggat aatcgtcatc agttcaattt tgaccatgct 27900
atatttgaga tgtaggaggt atccaagtag tacctattag ttggatgggt gggaggagcc 27960
aacaaatgag attaaggagg agtagcagtg aggggaggag gaaaaactga agaatgtggt 28020
ctgtgaaagc ctaggaaaga aattgatcac tagctttaag atgctggtct agtaacttac 28080
taaaagctgt ttggctaatg agaatgaata gagaggaaag agagagagac tgatgataga 28140
ggagaggaaa taaatagaaa atggaagtcc ttgaggcaag aggataggac actgagcaaa 28200
gtggtgggat cgtcaattga gagtggtcat ggagatcatg gtgatagaga tttggggtag 28260
gggaatgtgt gaaataggca tctaggagag taagggaaca gagtggcaca agccatagag 28320
ttaataaatg gcagggatag gattctgacc taggtatcaa gtttgatttt ttttctgtat 28380
taaattgcca cccctaggcc aggcgtgcct gtactggctc atgcctgtaa tcccaacact 28440
tgggaggcca aggcggacag attgtttgag cttaggagtt ctgagaccag cctgggcaac 28500
atggtgaaac cctgtctcta caaaaaatat aaaaattagc tggacgtaag tggcgtgtgc 28560
ctctagtccc agctactcag gaggctgaag tgggaggaca gcttgagccc gggaggcaga 28620
ggttgcagtg agccaagatt gtgccactgc ctccagcctg ggtgacagcc aggtcctgtc 28680
tcaaatttaa aaagccaccc taacaagcaa agtaataaat actaaaggtg tgttttcata 28740
gagaatcaga aaaattgaga ccaggtgagc ccaaaagtga agcttaaaag aaagcacctt 28800
actggctttt ctactcatgg caattattat ttgttacctt gtattatagt tatttgatgt 28860
acctctgtgc catgttactt caagtaagta tgaaattcct ggtggggtag agactgtgaa 28920
ctgacatttt gcctttacag acctagcact gcttttacaa ggtggatcct taaataatta 28980
ttgaacaaat agcctctgat tgatatgaga ggtgatattt atagttaagt gttacctttc 29040
taaaatgtca ttcaggccgg gtgtggtggt ttacacctat aatcccagca ctttgggaga 29100
ccgaggtggg ttgatcacta gaggtcagga attcaagacc agcctggccg acatggtgaa 29160
accctgtctc tactaaaaat acaaaaatca gccatgtgtg gcggcacatg cctataatcc 29220
cagctactcc agtggctgag ggaggagaat cacttgggag gcggagattg cagtgagcca 29280
agatcgtgcc attgcactcc agtctgggca ccagagtgag actctgtctc aaaaaaaaaa 29340
aaagtcattg agcagtccat cagcatggtt gtgtgctact gagatacgtt ctgatgtagt 29400
tttcacattt gccataagcc cagctcactc ttggtagtta gctaggacat ccattcccta 29460
ccaaaactct agcctacaga aggattggct cagtgtgttt agaagaggtt tgcaaatgtg 29520
tatgaccata gtccaagcag agagctaggt aggtgtgacc ttttgtgata aaagttttaa 29580
ttttgaagat ttctgcctga tgcatatttc tagatcagtg aagattggag gaagtttaac 29640
tcttgaatat ataacgccat aggtgcttaa atgtataaat gtcaaaacat gcatgacttt 29700
aactcattcg ttccaaactt ttccccccca caacagaggc ttccacctgt acttgctggg 29760
aagcggatca aggatttaga atcctaaaat taaaacaaaa catgaggtat agtgtaggat 29820
ggggcagcag gagcaatgaa attcctggtt tcctaatggt gaaggtaatc acttagtaat 29880
tgagaagagt tccctgccaa tatttctgtt tctgtcttgc tttgggcagg ggacaacaag 29940
cacctttctt ctaggaagtt aagggtactg ctatcctacc tctgggctag gatatgttaa 30000
aagcaatatt atgaaatact ctttgatttg taattggtgg cttcctttct tttgttatca 30060
gttttcctgt ctttgagttt tctcttcaca gtatcgttac ccctgtaatc tcatactcca 30120
gagtctagtt tttatgtagc ttatttttat cagtgcttac cagaatataa atttaggaag 30180
atttgaggta atgtttttcc agctgaggct ctaggatttc caagggtcca catactcttt 30240
tttttgagac agggtctcac tctgtggccc agactggagt acagtggcgt gatgttggct 30300
cactgcaacc tctgcctcct gggttcaagc gaatctcatg cctcagcctc ctgagtagct 30360
gggattacag gcatgtgcca ccacgcctgg ctaatttttg tatttttagt agagatgggg 30420
tttcaccatg ttggccaggc tggtctccaa ctcctggact catgtgatct gcctgccaca 30480
acctcccaaa gtgaaccacc acgcctggcc cacatattct taagggttgg gggggattct 30540
gtgagaattt ttaacaactt ttcatatttg attatcttta agtttaaaaa ataattacag 30600
aatggtttaa aaaatagaga tttccactgg gtacagttgc tcatgcctgt aatcccagca 30660
ctttgggagg ctaaggcggg aggatcgttt gagctcagga gttcgagacc aacctggacc 30720
acatagaccc ctgtctctac aaaaaatatg tattaaaata tattttttta aaacacagag 30780
atttcctata tacccttcac ccagattccc gagataagaa cattttacca catttgtttt 30840
gtcattcttt gtttatatac atatatgtat acatcattac ttttttcctg gaatgctgga 30900
aatttgcaga catgatgcct ctttactcct atatcctcaa atatgtattt cctaaaaaca 30960
acattacaat gatcaaattc aggaaattaa cactgataca atattatttt ctaacctata 31020
gaccttaaaa attattttga caagttttaa gtttaaaatt ctctgcaatg acagttttca 31080
aatgaaataa attttaatag gctaattttt gttttctgtc agaaatcttg aactgtgatc 31140
tattcttata tgtctgacag tttttttctt taaatgaggc ctatactaca ctcaagtgta 31200
agaaacactg tattttagtt ttagtaagaa atctttaggt aggagtgaat ttttgaagtc 31260
tttgcttatt aaaatcaagg taaagtaaaa agctatttct gatttgtagt tacgaaattc 31320
agtagaaggt ctggagtgag acctaggacc tcacttttgg ctgtccacct tgaggacagg 31380
aatattcttt gtcttatctt agttaagttc ttatccagat tcttaaacat ttttgatgtc 31440
aaggaatctt aagtgtcctg tacagtgaca catctagttt tgtttttgtt tgagacagag 31500
tctccctcta tcttctaggc tggagtgcag tggcacaatc tctgctcact gtaacttcca 31560
cctcctgggc tcaagggatc ctcctgcctc agcctcccaa gtagctgcga ctataggcat 31620
gtaccaccac acctggctag tttttgtagt tttgtagtag actttgtctc aaaaaatatt 31680
agcccggtgc agtggctcac acctgtagtc ccagctactc aggaggctga agcagaaaaa 31740
tcacttgagt ttggaaggtt gaggcatcag tgagccaaga ttgcgccact ggactccagc 31800
ctggaagaca gaatgagatc ctgtctcaaa aaaaaaaaaa aaaaaagata tgtgtatgtt 31860
catatatgca cacaaagttt tcgaataaga atatgcaaac taggccaggc acagtggctc 31920
acgtctgtaa tcccagcact ttgggaggct gaggtgggca gatcacgagg tcaggagttc 31980
aagaccagcc tggccagcat ggtgaaaccc tgtctctact aaaaatacaa aaattagctg 32040
ggcacggtgg ctcgcgcctg tagtcccagc tactcgcgag gctgaggcag gagaattgct 32100
tgaacccagg aggtggaggt tgcagtgagc tgaggtcacg cctctgtact gcagcctggg 32160
tgacagagtg agactctgtc tcaaaaaata agtaaattaa aaaaaaaaaa aaagaatatg 32220
caaacttaac aatagttgct ctggggagag tgatttgttt ttagttgtat atctctttgt 32280
attataaaat ttcccgcagc tacatatagt actttttcaa ataaagaaaa ttaatttggc 32340
caggtgcagt ggctcacgcc tgtaatccca gcactttggg aggccgaggc aggcggatca 32400
cgaggtcgag atcgagacca tcctggctaa cacggtgaag ccccgtttct actaaaaatg 32460
caaaaaatta gccgggtgtg gtggtgggcg cctgtagtcc cagctactcg ggaggctgag 32520
gcaggagaat ggcgtgaacc tgggaggcgg agcttgcagt gagctgagat cgcgccactg 32580
cactccagcc tgggcgacag agcgatactc tgtctcaaag aaaaaaaatt aatttaaaat 32640
gtactaaaaa tgagctaaaa gctgtcattc tgtaacttct atttgttggt cacagttctg 32700
actttcagaa ttgcacaaaa taagattatt tcatcttcta aactttctgg tagtttgaaa 32760
taaactacta tggtcctgta aatctttttt cttctaaggt agataaaaat acttctattt 32820
agctttaacc atttcttgtg tgacatggta tccagaatag atttctttac tatccaactt 32880
gtttatattt attaatgcgc ttgatagggc caaattgctc tcatttatag ggcttccctt 32940
tgtaaacctt acttctaatg tcctagcctg agagattggt tggttggttt tttttaagtc 33000
atgtcattct ttggttcctt gagcttgcca tgactaaaac tcttaactaa gtctttttct 33060
atatatacca tgtgacctaa tagagattta tcttcgtgtt gatatggatt ctttaaatat 33120
ataattccat cagcaagctg cagatttgcc cacttcacta tttttttgac agataactgg 33180
ctaacatatt cttttttttt tctctgtagt agttttttga aagaagaaat aggctattct 33240
agcatgatct catcctgtgg agttaaatac ttgttttcac atgcctcctt attttttatg 33300
gtagggagta caggaagttt aatactctta acttcttgtt tctataccct tgtttcatca 33360
acctttcttc aaaaactctc ttctttgctc ttgatattat ttaccgaaac aagtgttctt 33420
atgttaaaaa catttgtagc taattcttgc tgttaattgt ggtctcacaa ttgtattaat 33480
ttcttcaaaa aggtcctgcc ttcttattgc tgcagcagtc tactcttcct ggccgtacct 33540
aggtctccta cccaagaaga ctctcctgga aatgtacttc aactctaaaa taatactctg 33600
accataattt ccagttcttc caccttattg acccttctac ctctcttcct ggtttccacc 33660
aaatccactc tttaaagccc ccaatatctt gtccctaccc tattgagttt atgagcttcc 33720
ttcagatttc actccctgtc tattatctag ggatctttag gtcagttatt ttaatatttt 33780
tgagaaatca gttctctcaa cttcttgcct tctacccctc ttgtcccgcc aatcttgctg 33840
gattaattca ctagctgtta cctctgatgg cttaatccct tcaacaaaaa tagaataagt 33900
atgctaatga gctcaattat aaattggtaa tgtccaactt tgggcagcaa cattgaggat 33960
tacagtctac ttccacttct gttgcctaac gcttgaattt tctttgtctt ttaccctgtc 34020
tcttccccca gctttcaact aattatgtca gaaaagtaga gaccaatttt ttcttttctt 34080
ttttcttttt tttttttttg aggcggagtc tcattctgtc gcccaggcta gagtgcaatg 34140
gcgtgatctc actgcaacct ccgcttcccg gttcaagcga ttctcctgcc tcagcctccc 34200
aagtagctgg gattacaggc acttgccatc atgcctggct aatttttgta tttttgtaga 34260
gatggggttt ccccacgttg ggcagggtgg tcttgaactc ctaacctcag gtgatccacc 34320
cgccttgacc tcccaaagtg ctgggattac aggcgtgagc cactgcgccc agcctgtatc 34380
tccttctctt gagatcactt cctcaatcta atttggtgat tccatacttt ttctgtgatc 34440
taaacaactt gtctgctcac cagctctatc atgagggagg gaagcaagat acagaatggc 34500
ttgtatgttt ttaaaaagaa aaacaatgat ctctgtttaa aaaccacact caagtgcatg 34560
cacaaacgag tgcagaaagc tctgtagatc aaagtgttaa cagtagttgt ctctggaaag 34620
ttggattgtg gacttttctt ttgcttgttt gtaatttgat ttttatctat taacactaaa 34680
tgcttttaat gatgagaaaa tttccctcca aatttctgat tgtgcttata ttcttttatt 34740
ataaacattt tattttatca agttctggga aatgtcattt cttttctttt cttttttaaa 34800
cacttccccc tcctgtcttg tcatttctgt caaacaattc tttgatttct aaaatggacc 34860
ttcattatgc ccccttccct cccaactcca caaatttaca atataacctg agcctatttt 34920
catcatattt tgtcaggatt attcttttca tctgcctgtc caaaatagaa ctgctgaggc 34980
ttaagaaagt gttctggtca cttttgtatt tctagcattt cgtatgtgtg cgtactatgc 35040
agataagcct tggttggaca tctcctggta ccttctgtct tgaaaaaatt tcaaatggta 35100
ctaatttaaa tcaaattgaa tataccatag gttctaatat gccatcgatt gtaagaaaat 35160
gattatttta tgaacgttga gacgtgaaaa aaattttcag ttaaaactat tataccattg 35220
atagcatgca tcctgtgggc aaaatgtaca tcatagaatt gatgaagtac agtagtgcta 35280
acatcacatt tatgaggttt ttagtggttt tggagtagaa aaaaatggtt aattttggca 35340
ctgcttcaga tctcattcat gtattatcag cttactgccc cctctccccc tgtcattact 35400
tggttttgta tggctaccac agacactggc gaatggaatg aattatgatg aagttaggcc 35460
tacatttggg gaaaagggtt ttatatgttt cctttcagga acattgaaaa cagattgttg 35520
tattccagtc ttgccacata gtccaatgag tgactagctg aaaatacaaa tctcgctgtc 35580
atgtcctttt gtagcttcct tttctccaag tagacagtcc ctcagtatgc gttggtgtgc 35640
tagtgtacac tagacttgtg gcttttgatt gctcttagtc agtgtggtta cctttgttag 35700
aacataaccc agagagctgc gcattgtgtt atggagcaga tgcactgtaa tgtggaatag 35760
tcttgccttt ggaactgttg aacagatacc aaaaacgatt gagaagcatt gatccataag 35820
atgaaatatg attcttctca tgagaaacct gaccactgcc tcctactcca tcttattgtt 35880
ggcttctttc tgccttacac cttatattca ggtaatattg aactgtttat agatacttta 35940
cacatattat tctatgttat tttgtgtgtg tgtgtgtgtg tgtgagagag agagacaggt 36000
tttcactcag ttgctcagac tggagtgcag tggcatgatc ttggctcagt gcaatttctg 36060
tctcccaggc tcaagcaatc ctcccaactt agccttcctt ttaaaaatta tttttcattt 36120
tttgagatgg agttttgctc ttgttgccca ggctggagtg caatggcacg actttggctc 36180
actgcaacct ccacctcccg ggttcaagtg attctcagcc tcccgagtag ctgggattac 36240
aggcacgcac caccatgctc ggctaatttt gtatttttag tagagatggg gtttcaccat 36300
gttggccagg ctggtctcga gctcctgacc tcaggtggtc tgcccacctc ggcctcccaa 36360
agtgctggga ttacaggcgt gagccaccgc acctggccta aaaattattt ttaagagaga 36420
tgaggttttg ctatgttacc cagggtggtc tcgaactcct gaactcaagt gatcctccca 36480
atttagcctc ttaaagtgtt gggattacaa gtgtgggcca ctacacccag ccttatttta 36540
tgtgttaatc tctgactctg cctgggatct tctcacaaat gtattcttca aaaacgaatc 36600
gtctcttcag gatttttttt ttttttttaa agacagccat caccacagct ggagtgcagt 36660
ggtgtgatca tggctacctg cagcctcgac ctcctgggct caggtgatcc tcccacctca 36720
gcctcccagg tagctgggac tataagtgca cgccaccatg tctggctatt tttttgtatt 36780
ttttatagag acagggtttc accatgttgc ccagtgtagt ctcaatcccc tgggctcaag 36840
ccatcagccg gcctcagcct cccaaagtgc tgggattaca ggtgtgaacc accacaccta 36900
ggcaggaaaa attctttgca ttcctatttt cccactaaac tgagttgctt atcgtcctct 36960
ttgctgcctt actatatata tttctattct tatatttact ccattatgtt ggtattactt 37020
ttgttacaaa tttctttttt gtgacttaca ggaagctgag ctttttgagg gcagggatgc 37080
tgctttattc aaatttggtc tccagccctt agcacagtat gtgacactat cttgagtaaa 37140
tatttgttaa actaaatgta actgagtgtg aaggaatgga caatccatat agaatatacc 37200
tgtaggtagt aagtatccca agttttaata caaataacta ttatttcaat cgtttttaag 37260
tatttatgat ttctttttat tcttttgcat gttttcttgg ctgaatggaa atagagaaga 37320
agaaaatgag gtaagtataa tttaactagt cattcaatga ttatgagatg gaccactaaa 37380
cacattttag aaattgggta aaagctgaaa acactcaaaa tgtagctatc attttgaatg 37440
tgaaatgaag taatagtttt taattttgtt tttagagcca tggtaactta tcccagtgag 37500
ggatgttgtg tatctcagaa aaatggtttt taaactttag agcttcaaga gatttaggaa 37560
aggtagagaa agttggaagt tctaaaaata tcttttactt gttttttatg tattgagctt 37620
ccatttaaga tttaacttga aaagtggatt ctgtttctta aaagtatttg gctcatgcct 37680
gtaatcccag cactttggga agctgaggca ggtggatcac ttgaggtcag gagtttgaga 37740
ccagcctggc caacatggtg aaaccccatc tctactaaaa ataagaaaat taggcagaca 37800
tggtggctta gtcccagcta ctcaggagac tgaggcagga gaattgcttg agctggggag 37860
gaggaggttg cagtgagcca agatggtgcc cctgcacttc agcctgggca acagagcaag 37920
actctgtctc aaaaaaataa agtatttgga attcactgct ccatgataat atatgtgaaa 37980
gtatttactt tccaacttga atgactacta tgtaattttg aaaactgatt tcagatttta 38040
ctgtgttgaa agggaagtta ctctcttaaa tagccaaagt ggattaaaga acattaatta 38100
gaagaatttt gcatatgaga agtataccac catctttaat ttaggattga gtttgttgct 38160
gtagattttt ctgatgctct ttgtacaacc tacgttatgc cttgaacttc caaggctaac 38220
catttccttt ggtgatttgg caaacatgga agaaaagtag tcttcttagg tttatacttt 38280
gtaactgttg cttatacagc agtattatta cttgagggtg gggggcccag gcagagacag 38340
tgatatgtgc caaggcagag tactctccag gaaggcagaa ggcctggtcc tcatttggtt 38400
acctcatctg taaaacaagt aaggtgggaa gttcctctgt atcagtggtt tcccaaacct 38460
gggacattga ttagaattgc ctatgtaatg cttttttgtt tgtttgtttt ttttaaaaac 38520
caaaacctca aaacacccca aaaaacaaac cctttcctca tcttagagct caatagctcg 38580
ttgatatttg atatttccta gagtgtggat cacagatgag tatgtttttt tttttaattt 38640
ttaaattttt tatttttttg agacagaggc tcgctctgtt gcccaggttg gagttctgtg 38700
gtgccatctt ggctcactgc aacctctgcc tccggggttc cagtgattct cccacctcag 38760
cctcccaagt agctggggtt acaggtgcat gctgccacac cctgctaatt tttgtatttt 38820
tagtagagat gggttttcat tatgttggcc aggctggtct cgaactcctg acctcaagtg 38880
atcctcccgc ctcggcctcc caaggtgctg ggattacagg tgtgagccac tgtgctcgac 38940
ccagatgagt atttttactg tgcactccat gtgatgccag gagaccactg gtcttgatga 39000
cctctgattt ttcatctctg atagaacaca agaacaaacc atattgagta ctgagatgtt 39060
agatattgcc ctttatacaa atgtctttca aacatatgtc aggtttttaa aaaattcttt 39120
ttaaaaaatg ctacctggaa aatagttata aaactgaaaa aagttattta tgtacgagaa 39180
agtaagaatg gggaaaatag gtaattgttg aagcttggag tggatactta gggatttatt 39240
ataccatttt ctatactttt gactgtgttt gaaaattttc ataataaaga tatatatagc 39300
ttagtgaaat tcatactatt tgttattaaa aagggctttt catttctcca gtaaacattt 39360
taaactgtgc agtccatttg aaagtaacta tttattgtag tagtaattgc ttattttgtt 39420
catttgtagg caaagattga aaatgtgcag aaaacaggtt tcatcaaagg accaatgttc 39480
aaaggtgttg cttctagtcg atttttgccc aaaggcacca aaacaaaagt taatttggaa 39540
gaacagggac gacagaaggt gtcattcagc ttcagcctta caaagaaaac tttgcagaat 39600
aggtttctca ctgcacttgg caatgaaaag caaagtgata ctccaaaccc tccagctgta 39660
cctcttcagg tagactcgac tcctaaaatg aaaatggaaa ttggtgatac cttatctact 39720
gcagaagaat cttccccacc aaagtcaagg gtggaattgg gcaaaattca ttttaagaaa 39780
catctgcttc atgtaacatc caggccactg ctggctacta ccacagcagt agcatctcca 39840
cctactcatg cagcaccatt accagcagtg atagcagaat caacaactgt agactcaccg 39900
ccctcatctc cgcctccacc gcctccacct gcccaagcca caacactctc atcaccagca 39960
ccagtaacag agccagtggc cttgccacat acaccaataa cagttctaat ggcagcacca 40020
gtacccttac cagtagatgt agcagttaga tctctgaaag aaccaccaat tataattgta 40080
ccagaatctt tagaagcaga tactaagcag gacactatat ctaatagttt agaagaacac 40140
gtaactcaaa tattgaatga gcaagcagat atttcctcaa aaaaagaaga ttcccatatt 40200
gggaaggatg aagaaattcc agatagttct aagattagtc tgagctgtaa aaaaacaggt 40260
tctaagaaga aatcctcaca atctgaaggc atctttcttg gttcagaatc tgatgaagat 40320
tctgtacgga cttcttcaag tcaaagatca catgatttaa aattttcagc aagcattgaa 40380
aaggaaagag attttaaaaa gagctcagca cctttaaaaa gtgaggatct agggaaacct 40440
tcacgatcta aaacagacag agatgataaa tattttagct attcaaaact tgaaagagat 40500
actcggtatg tatcttcccg atgtagatca gaaagagagc gacggcggag cagatctcac 40560
tctaggtctg agagaggctc tagaactaat ttatcctatt ccaggtcaga acgatctcat 40620
tattatgact ctgatcgtcg ctaccatagg agctcccctt atcgagagag gacgcgctat 40680
tctcggccat acacagataa cagagcacga gagagttctg actcagaaga agagtataag 40740
aagacatact caaggcgtac ctcatctcat tcctcttctt acagagacct aaggacatca 40800
tcctattcta aatctgatcg ggactgtaaa actgagacct cttacttaga gatggaaaga 40860
agaggcaagt attcttcaaa actagaaaga gaatctaaaa ggacttcaga aaatgaagca 40920
attaaaagat gttgttctcc ccctaatgaa ctgggattcc gacgagggtc atcatattct 40980
aagcatgaca gtagtgcttc ccgttataaa tctacccttt caaaacctat acccaagtct 41040
gataaattta aaaattcttt ctgttgtaca gaattaaatg aagaaatcaa acagtctcat 41100
tcttttagtt tacagacacc ttgttcaaaa ggtagtgaat taagaatgat taataaaaat 41160
cctgaaagag aaaaggctgg gtctccagct ccatcaaatc gattaaatga ttcacctact 41220
ttaaaaaagc tagatgaatt gcctattttt aagtccgaat ttataacaca tgatagccat 41280
gatagtatta aggaattaga ctctttatct aaagtgaaga atgatcaatt aagaagtttt 41340
tgtcccatag aattaaatat aaatggatct cctggggcag aatctgattt ggcaacattt 41400
tgcacttcta aaactgatgc tgttttaatg acttctgatg atagtgtgac tggatcggaa 41460
ttatcccctt tggtcaaagc atgcatgctt tcatcaaatg gatttcagaa tattagtagg 41520
tgcaaagaaa aagacttgga tgatacctgc atgctgcata agaagtcaga aagcccattt 41580
agagaaacag aacctctggt gtcaccacac caagataaac tcatgtctat gccagttatg 41640
actgtggatt attccaaaac agtagttaaa gaaccagttg atacgagggt ttcttgctgc 41700
aaaaccaaag attcagacat atactgtact ttgaacgata gcaacccttc tttgtgtaac 41760
tctgaagctg aaaatattga gccttcagtt atgaagattt cttcaaatag ctttatgaat 41820
gtgcatttgg aatcaaaacc agttatatgt gatagtagaa atttgacaga tcactcaaaa 41880
tttgcatgtg aagaatataa gcagagcatc ggtagcacta gttcagcttc tgttaatcat 41940
tttgatgatt tatatcaacc tattgggagt tcaggtattg cttcatctct tcagagtctt 42000
ccaccaggaa taaaggtgga cagtctaact ctcttgaaat gcggagagaa cacatctcca 42060
gttctggatg cagtgctaaa gagtaaaaaa agttcagagt ttttaaagca tgcagggaaa 42120
gaaacaatag tagaagtagg tagtgacctt cctgattcag gaaagggatt tgcttccagg 42180
gagaacaggc gtaataatgg gttatctggg aaatgtttgc aagaggctca agaagaaggg 42240
aattccatat tgcctgaaag aagaggaaga ccagaaatct ctttagatga aagaggagaa 42300
ggaggacatg tgcatacttc tgatgactca gaagttgtat tttcttcttg tgatttgaat 42360
ttaaccatgg aagacagtga tggtgtaact tatgcattaa agtgtgacag tagtggtcat 42420
gccccagaaa ttgtgtctac agttcatgaa gattattctg gctcttctga aagttcaaat 42480
gatgaaagtg attcagaaga tacagattcg gatgatagca gtattccaag aaaccgtctc 42540
cagtctgttg tggttgtgcc aaagaattct actttgccca tggaagaaac aagtccttgt 42600
tcttctcgga gcagtcaaag ttatagacac tattctgacc attgggaaga tgagagattg 42660
gagtcaagga gacatttgta tgaggaaaaa tttgaaagta tagcaagtaa agcctgtcct 42720
caaactgata agtttttcct tcataaagga acagagaaga atccggaaat ttcttttaca 42780
cagtccagta gaaaacaaat agataatcgc ctgcctgaac tttctcatcc tcagagtgat 42840
ggggttgata gtacaagtca tacagatgtg aaatctgacc ctctgggtca cccaaattca 42900
gaggaaaccg tgaaagccaa aataccttct aggcagcaag aagagctgcc aatttattct 42960
tctgattttg aagatgtccc aaataagtct tggcaacaga ccactttcca aaacaggcca 43020
gatagtagac tgggaaaaac agaattgagt ttttcttcct cttgtgagat accacatgtg 43080
gatggcttgc actcatcaga agagctcaga aacttaggtt gggacttctc tcaagaaaag 43140
ccttctacca cgtatcagca acctgacagt agctatggag cttgtggtgg acacaagtat 43200
cagcaaaatg cagaacagta tggtgggaca cgtgattact ggcaaggcaa tggttactgg 43260
gatccaagat caggtagacc tcctggaact ggggttgtgt atgatcgaac tcaaggacaa 43320
gtaccagatt ccctaacaga tgatcgtgaa gaagaggaga attgggatca acaggatgga 43380
tcccattttt cagaccagtc cgataaattt cttctatccc ttcagaaaga caaggggtca 43440
gtgcaagcac ctgaaataag cagcaattcc attaaggaca ctttagctgt gaatgaaaag 43500
aaagattttt caaaaaactt agaaaaaaat gatatcaaag atagagggcc tcttaaaaaa 43560
aggaggcagg aaatagagag tgattctgaa agtgatggtg agcttcagga cagaaagaaa 43620
gttagagtgg aggtagagca gggagagaca tcagtgcccc caggttcagc actggttggg 43680
ccctcctgtg tcatggatga cttcagggac ccacagcgat ggaaggaatg tgccaagcaa 43740
gggaaaatgc catgttactt tgatcttatt gaagaaaatg tttatttaac agaaaggtaa 43800
gtctaattaa tacttgtttg acaaatttta actctttttt tgttgttaga aaaagccttt 43860
aaacaattca gactgtatga gattaaacac atgaaagagt tgtgggataa agtaaattta 43920
aaagtctaaa aaagtgtttt tacctattta gatttgatag tatagattcc tttccccatt 43980
ccccccgccg ccccatcccc aggaaaggag atgtctattt ttttctttca ttacttgttt 44040
ggttttcaag gtacaattta ggctagccca gtatttctgt aattcctttt acatgtgaaa 44100
gtctgaccaa aaaaacagaa taaaacccca gcaaaataat ctgtacttag agaagaaaaa 44160
agtggttact ttggatttta ttttcaaaaa tgtgcagaat gaagtatctt tgggtactgt 44220
attagtccgt tttcatgctg ctgataaaga catacccgag actgggaaga aaaagaggtt 44280
taattggact tgcagttcca catggctggg gaggcctcag aattgcggca ggaggcaaaa 44340
ggcacttctt acatggtggt ggcaagagaa aaagaggaag aagcaaaagt gaaaaccctt 44400
gataaaccca tcagatcttg tgtgacttaa tcaccatcac aagaataaca cgagaaaggc 44460
cggcccccat gattcagtta cctcctcaag ttgagtttgg gtggggaaac agccaaacca 44520
tatcaggtac ttataaagtt agaactagac tagaacataa ttttcttctc tcattttttt 44580
ttagactatt gttaatagat taaatctggc aatagtgtaa taaatatttt agaaatgata 44640
aagtggttta tcaaaaaatc cctaacatga aacaaattat aatgagaata agagtaatga 44700
aaacatagtc ctctagagca gggcttctca gtctgtttta actttaaccc ctccttgata 44760
attttctcat tttcctgatg taaatttata ttgattgtgc ttaaaaaacc aaaacaaaaa 44820
gtatcctgcc cccttactct ccttttttgg aagttttcct gctagttgag aatcaaccta 44880
gccattgtat ctttaaggat caaaatgtta ttaaatcaaa ttttcctctg tgtataaggt 44940
aaaagactta attttaaagg taggtcctac cagaaatttt tttctattac aaaataacct 45000
tttaacagag agccttttac agctattttc atttatatct agttataaat taagtttaca 45060
tttaaaatat tcaatatttt aagtagtacc ctttaggaat tgtgtgagta gactaatgga 45120
acttacaaga tctttgtaaa agaatataaa taaaactaat cagtccaatt ctctgacttt 45180
tctttagcat tgagaatcag atatatatat ataaaactgt gcacatagat ttggttagtg 45240
gaggcataag agggcttcca ccactttgca gtgggaagga tttatatata tttaactttt 45300
tttttttttt tttgagacag agtctcactt tgtctcccag ggtggagtgc agtggcgtga 45360
tctcagctca ctgcaacctc tgccgggtgc caccacgccc agctaatttt tgtattttta 45420
gtagagatgg gtttcaccat gttggccagg ctggtctcga actcctgacc tcaggtgatc 45480
cgcccgtctc agcctcccaa agtactggga ttacaggcgt gagctaccac gcctggccta 45540
tatattcaaa attttgaagt gcctgttata tgctaggcat ttaggagcca ctaagaagac 45600
aaactcttat aaaaaataat atgaatataa tgaaaacatt tttcttatgt ttaatggaaa 45660
agggcttacc tgccaaaatc tatgcccatt cgtcctattc cagccttcta gagcaataca 45720
aaataaagct gctgctgatt cttcaaaatt gtagctaagt acttctaaat agataatttc 45780
gtttagtcat cttcaggcta agcatattca tatactcatt aacgaattgt gtctttaatc 45840
aagaggaatc attcttttca cctaaactta gttaaaacta tcataacact cttgaggcac 45900
ttcataaaat tggcactaga atagaacata tgttgaagat caaagcagat tagaggtagg 45960
agattagata accatttaga gcagctatgc tgtttcctgt ttgatagtca aagagtgagt 46020
tatagttctt atagttccct aatcttaaac ataacagatc ttttttgacc atctttggtt 46080
gttttgtttt gtttttagac cagggtaaaa gactagttca tcagcaaaaa ggccaataaa 46140
taatcacatt ttcacttttg ctttgcacac tctggcatgg cttattatga acgcaatcaa 46200
attttagcag tttatgttct tctccaaaat aaatctgtct gcatggagaa agttgagccc 46260
tcttaaacat ttacctgatt attctgtaat tacacttcat ttaaaaaatt cagtctgctt 46320
ttaaacaaaa tttatgcaga tgtgatgtta ctgaaagatt ctctaaaata ttggattgag 46380
ttagaactca ctcttatttt tttagaaacc ccttttctcc ctcaatctta tatctcaact 46440
attatttgct catccatgag gtctgattct taaacttaac tttaaccagc tatgtcacta 46500
tttgaaatgc atgagttttc ctatttttcc tagaacctag tatgacttta acacttgaaa 46560
ctgttctgaa tccaaggctt agctgacctg gagtaggaaa taagggctga gttccagaat 46620
gagtagtctt gaactcatct catcttcccc atttgccaag gttaaggttg cccttctcat 46680
gttttttttt ttgtttgttt tttttttttt ttttttggta atgcaggtct taggattttc 46740
agtctcacaa gtactaataa ttagatgttt tattttgaat ggttgactta caggaatcat 46800
taaatgtgaa tctagccagg cgtagtggat catgcctgcg attgcagcac tttgggaagt 46860
ggaggcaggg gaatttcttg agcccaggag ttcaagacca gcttgagtaa catagagaga 46920
ccctgtctct acagaatatt aaagaacaaa caaacaacaa caataacaaa aaccaagcgt 46980
ggtggcatga gctgtggtcc cagctattca ggaggtggaa gtgggagggt catttgaatc 47040
caggaggttg aggctgcagt gagccatgat cgcatcactg caccctggcc tgggtgacag 47100
aacaagaccc tgtttaaaaa aacccaaaag aatctaatga gatttggcac atatttgatt 47160
atatatgtta tatctttacc aggaaattta tttaatcagt ttttatgaaa ttttacccaa 47220
tagaaagaag aataaatctc atcgagatat taagcgaatg cagtgtgagt gtacacctct 47280
ttctaaagat gaaagagctc aaggtgaaat agcatgtggg gaagattgtc ttaatcgtct 47340
tctcatgatt gaatggtaag taaattagaa tactcggctt ttgctcaaca cttctattaa 47400
atgtctctaa atattgaatt atcaatgaag aataaaattt aacctttctc ctacctatgg 47460
atgactacaa gcaaaaaagt atagtagaca ctttgatgta tagtagaaaa catattaata 47520
gggaaacaaa tatcccttgc attgtgcatt agattacagt acccaccatg ttttaagtgc 47580
ttggtaaagt agtcctataa tattaatttc tattcagtac ttttttatct tttataatat 47640
ttatgtccta gaggtaaatg ttggtatttt ttagctttca ctataaagtg aaataaaacc 47700
ctaacatttc agaaatgcat aaagtgaatg tcttctccca aacatcagtc ccattgtttt 47760
gtcatttttc cagaaaactt ttaatgccta tgctagcata ggtagatgtt ttcctctttt 47820
tatgtataca gataaaatct tattctatat acttgcttgg atttgctaat cagacctaat 47880
cagagctctg tgtacagacc tgcctaaatc tttctcttga ctgcattatg tattctattc 47940
atagttagcc ggtaattagt ctgttgacag acatttgctt ctgtattgtt cttataaata 48000
gtaaatatct ttacattaaa aaatttaatt ttggccaggc gtagtggctc atgcctgtaa 48060
tcccagctat ttgggaggct gaggcgggca gatcacttga ggccaggagt ttaggatcag 48120
cctggccaac atggtgaaac cccatctcta ctaaaaaata caaaaattag ccaggcatga 48180
tgacacacac ctgtaatccc agctactctg gaggctgagg caggagaagc acttgaaccc 48240
aggaggtgga gcttgcagtg agctgtcatt ccactatact ccagcctggg tgacagagcg 48300
agatgttgtc tcaaaaaaat ttttttaacc aatctgattg atgaaaaata tattcttgtc 48360
ttttacatgg aaagagtata ccttattttt gatgttagtg aaggtttttt ttccccaaag 48420
ctcagttttt ggttttgctc atgttatagt gttgcaaaaa taaaatatat ataccttgaa 48480
aaaataaaga gaaaggattt ttggtattct tttatccaaa ctagagagag agatgacagt 48540
acagatgtaa gaagagaaga catagagtta gcattattct aacttcatat tgttgcccta 48600
gtcattcttc tgggttttcc tgccaacctt gtgaagcata catgaagaaa aatatttctt 48660
catattattc acacacttaa gcttttggta gttctcggtt gttctcatga ttaggttcaa 48720
acttagcctt gtattcagag cccttggtag catatcatca gcctgtcttt tcatcctcca 48780
gcaactcacc tttcttatca gttatcttta gttgtttcat ttctctttgt ccaaacaggg 48840
attgttttcc tatttctgca cacagacagg gacagttgta tctccagctt tctttatgca 48900
tatcctatgt atcattagag attctgcctt aaattctctt ccctcctgaa agctttcctt 48960
tatactgcct cactctagag caaatccttc atcctttgac cattgctaaa aatgttattt 49020
gctgctgggt gggcaataaa taataatata ttcaaaatga ttggtaattt ccagtggtct 49080
tttttttttt tttttttttt tgagacagtc tccctctgtc gcccaggcta gagtgcagtg 49140
gcacaatctt gactcactac aacctctgcc tcctgggttc aaacaattct cctgcctcag 49200
cctcccaagt agctgggatt acaggcgtgc accatcatgc ccggctaatt tttgtatttt 49260
tcagagagac aggatttcac tatgttggcg agggtggtct tgaattcctg acctcaagtg 49320
atccacctgc cttggcctcc caaagtgctg ggattacagg catgaatcac cgtactcagc 49380
cccctctggt gtagttttaa tcatcgttaa aacctttata tctatcacat attaagaagt 49440
caatcagtgt tcgattttat catttttact ctaggatcca tgggagaaga gccatgccat 49500
gttattctgt ttactctgaa caaggatata tttaataatg actttagatt ttctcaattg 49560
tagatcaagt agttagctgc attcaaaaaa tgaaattaaa agtgattaga gtagaaggaa 49620
gggaaggtgc acttacagaa tataagttct gcagagttgt caatgtactg aaagcttaca 49680
tgcagcctga aaatgtattc tagacaccta gggagtggta gatatttctg tgatgaccag 49740
atatcaaggc tgtattgtgg gtatgatctg tttaagtaac aatgtagata ctcagttcta 49800
aggaatccct ttgtgatgga aggaaaggaa gacttagttg ggggttagtc atacatatgc 49860
taattatacc ataaaagtat gtatatatgt agttatacta acacattttt tcaaagttac 49920
tttggttctt ttgctgcttt aaagaattaa atttcctcct tttctcattt cagttcttct 49980
cggtgtccaa atggggatta ttgttccaat agacggtttc agagaaaaca gcatgcagat 50040
gtggaagtca tactcacaga aaagaaaggc tggggcttga gagctgccaa agaccttcct 50100
tcgtaagttc ttttttaatt acctttcact tccttttttg agacaaggtc tcactctttc 50160
acccagactg gagtgcagtg gcacgatctt ggctcactgg aacctctacc tcccggattc 50220
aagcaattct cctgccttag cctctcaagt agctggaact acaggctcat gccaccatgc 50280
ccagctaatt ttttttgtat ttttttggta gagacgttgt ttcaccatgt tggccaggct 50340
ggtttcgaac tctgaccgca agttttccgc ccaccttggc atcccaaagt gctgggatta 50400
caggtgtgag ccgtcgcgcc tgggcttcac ttcatttttg tgttgttgaa cttagatgtt 50460
tttgtaggga aacaatttct ttattacact gaggtttaat gatgattatt atgtagaatg 50520
accacttggt agctagtttg ttgttaaaaa atcttttttt cttttttggt aattatgttt 50580
tctttaattc caagcaacta ccaagtgttt actgtggacc cccagaatct ctatgaagct 50640
atataaaaag aagttgggac agaatccatt agtatacata aaattgagtt gggataagag 50700
tagaagagaa ggccaggtgc agtggctcat gcttgtaatc tcagcgctat gggaagctaa 50760
gtgggaggac tgcttgagcc tgggagttca aggttacagt gagctgtgat cacgccactg 50820
cattctagcc tggatggcag tgatctcttg tctcttaaag aaaaaaaaaa agagtagaag 50880
agaatacctg agcatatcaa ggttaagaat taaaacatac ttgatagata atcattaaac 50940
atttcttgaa tgaataaatg ttgctttcca tgtaactgat gtaagttttt aatgtaatac 51000
agcaaaaggt tcactttatt ttctaccata ttcagtattt cctggaaatg tttaattttc 51060
ttatatatag catatttaaa gtattcttgg ccgggcatgg tgactcatgc ttgtaatccc 51120
agcactttgg gaagccaagg tgagtggatc acctgaagtc gggagttcga gaccagcctg 51180
gccaacatgg cgaaaccccg tctctactaa aaatacaaaa attagatggg tgtggtggcg 51240
cacgcctata atcccagcta cctgggaggc tgaggtagga gaatcgcttg aacttgggag 51300
gtggaggttg cagtgagccg agatcatgcc actgccctct agcctgggag acagagcaag 51360
actccatctc gaaaacaaac aaaaaaccca aaattacgct ggacgtggtg gttcacgcct 51420
gtaatcccag cactttggga ggccgaggtg ggcagatcac ctgaggtcag gagttcaaga 51480
ccagcctggc caatgtggtg aaaccctgtc actactaaaa atacaaaaat tagctggatg 51540
tggtggcagg caccaataat cccagttact tgaggggctg aggcaggaga atctcttgaa 51600
ccggggaagc gaaggttgca gtgagccgag attgcgccat tgtactccat cctgggtgac 51660
aagagtgaaa ctctgtctca aaaaacaaaa caaaaattag ccaggcatga tggcgcacag 51720
ctgtaatccc agctactcgg gaggctgagg cagaagaatt tgcttgaacc cacgaggagg 51780
aggttgcagt gagccgagat catggcactg cattccagcc tgggggacag agcgagactg 51840
tctccaaaaa aaaaaaaaaa aagtattctt aatgaaggtc aagtgcctct ttgaagttaa 51900
atataaacag attacatgtg tttatggttg aaacatttaa aaaatatata aaagaaaaaa 51960
tggaaggaaa taaaacattt gctggattct agtaacttag acataactat tctttcagaa 52020
ccctctgagc atatggccac agttggatgg gagttggagt tggggcagga cttggtgggg 52080
tttaatctgt ttattgtggg aattcaaaac acaggtaata aagacaataa tttttttttc 52140
tcactgtttt ccccttggca ataatttagt tttatgacag gaatcctcat atatcttttg 52200
ataagcaaat tgttcttttt ttttttttcc tttgaagata agaaatgatg ttgatattaa 52260
tctatccttt tgggaaccaa tcagaaagca acatgttttg ttacacaaaa agggggctag 52320
taggaacctc atagatttct cttctcctct aagttttgta aaaacacacc ctggctcata 52380
actggttttt attgtttttt atttttttga gacagggtct tgccctgtca ccctcgctgg 52440
agtatcctgg cgcaatcata gctcactgca gtgtcgacct cccaggctca atttatcctc 52500
ctgcctcagc cttctgagta gctgagacta taagtgtgag ccagtatgcc cagctacttt 52560
atttttctat tttttgtaga gatggggtcc tcactatgtt gcctaggctt ctcataactg 52620
gtttttaatt gtttatttga agcaaatatc ccacagaatt gtcatatgcc ccatatccat 52680
tcattggatt ctttataata ttttaaacaa ataattggtt acacttcctt tgaacactgt 52740
tgatacagaa ctcaatacct ctcaaagcag cccattgaat ttccaaaatc actagttcta 52800
gtccagacgc acattttcaa agatgccttc tttcattctg ccctagccag ccaggccttc 52860
ttgagatttt tttttttttt tttttttttt ttttttttaa aggaaccaca gtttggacac 52920
aagcctctct tacagggaca atagtggatg agctgtctgg atgctggtct tttgtggtat 52980
ctgcagtaaa acacatagct tcaaacctga tctaaattct gttacttgca acagacactc 53040
tttgatagct cagtgctctt ctcatattaa ggggaaagga gactggggaa gggaggaaag 53100
gatatatggc tccagtttat aagccaggtt aaaatttcct aaagctcttc cgttttcttc 53160
agctattcac agagaaccct gctttggtaa aatatactag gacttaatgt ttccatgttt 53220
cccatacctt cctactccta taactgccac atgatgatgt gtaataccaa tagtttatga 53280
atttcataaa ctagtcaaaa ctcttgcgtt gtttactggt agagtattac catttaataa 53340
ggacagattg tcagagctac acaggatgag aaattatttg gagctaagtt actagttagt 53400
gttaaagtgc catggcagac cccaccaaaa aagcaggtta ttaccaaaac ccctgtagtt 53460
ttaggaaatc tcccagttgt aggaagagaa ggcagtccag gttgacttaa tgtaattgga 53520
taccagatag ggttttaatt gaggtaaaat tcacataata taatattgac cattttaaag 53580
tttacaattc agtaccattt agtgcattca taatcttgtg caactgccac ttttgtctgt 53640
gtccaaaaca ttttcatcat ctgaaaaggg aactaactct gcctgttaag cagaatcttc 53700
tcatacctgc ctcctcccag gcctggcagc cactaatttg ctgtctgttt ctgtgggttg 53760
atctattctc ggtatttcgt ataaatgaaa ttatacaata tgtggccttt tgtgtctggc 53820
ttctttcact tagcattatg tttttgaggt ttcatctgta ttgcagcatg tgtcagcact 53880
taattcctat ttatggctga ataatactct cttgtatggg tatacgatat tttgtatatc 53940
cttttgttag ttgatggaca tttgggcaaa tgaggctttt tttttttttt ttgagatgga 54000
gtcttgctct gtcactcagg ctggagcaca gtggcacgat cacggctcac tgcaacctct 54060
gcttcccggg ttcaagtgat tctcctgcct cagcctcctg agtagctggg attacaggtg 54120
tgcgccacca tgcccagcta atttttctat ttttagtaga gagggggttt caccatgttg 54180
gcccagctgg tctcgaactc ctgactacag gtgatccgcc tggcttggct tcccaaagtg 54240
ctgtaattac aggggtaagc caccgtggct ggccgaaatg aggctttttt agaagccatc 54300
tttcccctcc acattttttt gttgttttcc gacacagggt ctcactgtgt tgcccaggct 54360
tgaatgcagt ggcgcgatca cagcttactg ctgcctcaac ctcctgggct caggtgatcc 54420
cccaacctta gcctcctcag tagctgggac tacaggtgta cactaccata ctctgctaat 54480
ttttttgtat ttttagtaga gacagggttt tgccgtgttg cccaggttgg tctcgaactc 54540
ctaagctcca gtgatcctct caccttggct ttccaaagtt ctggtattac aggcgtgagc 54600
caccacccct ggcccgtttt attaataaaa agtttcaaac ttacagaaaa gttgaaagag 54660
ttgaacagtt agtgtccatg taagcaccac ttaggtttta tagttattaa cattttgttc 54720
tgtttgcttt attttacatt ctctgtctgc ccgtctcttt tttatctatc agtctttttt 54780
tgatgaagct taaagggagt tgcagacgtt acccttaacc cctaaacctt ccatagcttt 54840
gcagtgacag tgacaatttc tgtccccacc cacctgccat agtagagccc tgttgccctg 54900
aacaggcttt aaggagaagg agttcaatga agtgacccta ttcagccagg agcaaatttc 54960
aggcttagaa aaagattaat aagaatcata agaatcacac ttctcattgc ctttgccttc 55020
atgggattta gtcactgcat gccaggcaat atgatgtttt ctgctttgtt tttgttttta 55080
ttttggtttt taattgagac acgtagcttc tctaagaaac ctaaatctta gagttttaag 55140
gactgcatga tagactttta cactggcctc atttagtttt ttggaggtca ggcagctgga 55200
gggtctagcc actcttccta cattccccaa attcctgagg actttgagat gcttctctca 55260
gctgcttcct caagctcaaa ctgttagatc catgtgtgtt ggtatatcct tccaacttcc 55320
tgatgtgggg tctctactct gagtgattta ctggctggtc aggctctgat atttaagaac 55380
tttttctaaa taaggtgatt tgagagtaat atcattagaa ttgaatattt tagtaaaatt 55440
caagaaagca tctttataat ataatgaggt aaatagttat ttaggtggag tttgaatccc 55500
aggctgtaat tgagctttat gaagttggat agatcaccta cattatccaa actctgtctt 55560
atttgtcaaa tgggcataat atcgatgcca gatgacatca atatgcttta tttttatttt 55620
tcatactacc tttcaaaagc aggtaatcaa gccttaaatg agtaagttta gggaagatag 55680
atttttggca gaagagggat tggaaatatt ttttatgtgt gcagttccag atcctggata 55740
atatatgttt tgtagtcacc acatttaatt cacaaggcag tccatgatgt catttttctt 55800
tttctctctt ttttaagttt ttaaaaaatg ttttaaaaca ttttttaaaa tttatttatt 55860
ttggtagaga cgggatttca ccatgttgcc cagctggtcg gaaactccca ggcttaagtg 55920
atctacccac ctcggcctcc caaagtgctg gaattacaga cttgagccac tgtgcccagc 55980
ttttttttct tttttaatgc aatggggtct tgctctgtca cctagcctgg agtgcagtaa 56040
tgtgattgta gctcattgta gattcaaact cagggctcaa gcaattctcc tgccccaggc 56100
tttcaactgg tgtagtggac tataggcaca taataccatg gccggctaat tttttaattt 56160
tttattgttt gtcaagatga ggtcttcctg tgtttttcag gctggtcttg aactcctggg 56220
ccaaagcaat cctgccaccc cccccccacc cccccccgcc acccaaagtg acttttcttt 56280
ttcttgaggg agggcactaa tcctggaagt ggagagtcca acattgtagg acctcaaatt 56340
ttgtcatcat tttaaattat ttgcaagatg ataagcttct ggggttagaa aggacatttc 56400
aaatattggt tatagaggta ataatttgac tttctaggtt tacccatgaa taatcagatt 56460
tttattattg agacctaaat gtgtttgtga tggactacta tataaatata tatatacatc 56520
cactataaac ttctccaatc ctgtttttga gctctgcttt ttaatatatg tgttcttttc 56580
tcatttgttt ttaattgctt tattttttaa agtaaaagga tttaattttt ttcagttggc 56640
gaagttaact cctttaataa gtacattgat tatgccagta tgttgtaaac aaatacaaaa 56700
gatttacatt aaaaaaattt ctttcattag aattagggta tgtttatttt gaggggataa 56760
gaaaagactt tcaggcaggc cattttatgt cagaacttca gagtaaaaca tagtataaca 56820
tttgtctaca tagaactaat agttgaagtc attggttaga atgagctttt agagaattaa 56880
gagaagggga aaagactgat aatttaatat cttcagttca gaataaatag gtaaataatc 56940
aagaaaagaa cattcaaaga taaagggtaa ctgaaagatg ccaaagaaga agataaataa 57000
caattactga taacattcta aagagacgtc aaagagaatg tcattacata aagggaatta 57060
gatttgatct ttaacatttt tagagacctt tgagagtaaa gacagcagaa gggctgctat 57120
atttaagttg ccttcttctt tttctttttc cttttttttt ttttttgaga cggagtctca 57180
ctctcttgcc caggctggag tgcagtggcg cgatctcggc tcactgcaac ttctgcctcc 57240
caggttcaag caattctcct gtctcagcct cccaagtagc tgggactaca ggtgcatgcc 57300
accacacctg gctaattttt gtatttttag tagagatggg gtttcaccat attggtcagg 57360
ctggtctcga acttgtgacc tcaggtgatc cacccgcctc tacctcccaa agtgctggga 57420
ttataggcat gagcctctgc gcccggctgc cttttttttt tttttttttt tttttttttt 57480
ttttagagca aaaatcctct aacttttcag tgtctcttga tttcttcaga gctgttttcc 57540
agctgttaat aacttttttt gatattgtaa gccagacttg aatgatttag tatctagtta 57600
aaggatatat attttggtag taggtataaa ttataaaagc atcttagaat caacattctt 57660
tgaaaagtac tgtgaaggag aaaagtaacc ttggttagaa gctagatact tgacatgtgt 57720
ttgaaattta ttttgtgtaa taactgaatt tatccacatt gcagtattta tttaaattcc 57780
ttatttttgc ctgagcatat atgttttccc tactgctcct aggtaggaag tgctattttt 57840
ttccttttgg tttgcaggaa cacctttgtc ctagaatatt gtggagaggt actcgatcat 57900
aaagagttta aagctcgagt gaaggagtat gcacgaaaca aaaacatcca ttactatttc 57960
atggccctga agaatgatga ggtaagcagc ttggatatgt ttgccttgaa acagatctgt 58020
taggtttgaa ggagccattg atactgattt gatttttttt tttttttttt ttttggagac 58080
ggagtctcgc tctatcgccc aggctggagt gcagtggcaa gatctcggct cactgcaacc 58140
cctgcctcct gggttcaaga gattctcctg cctcagcttc ctgagtagct gggattacag 58200
gcgcccgcca ccacgccttg ctaatttttg tatttttagt agagacgggg tttcaccacg 58260
ttggccaggc tggtctcgat ctcctgacct caccaaagca ttgagattac aggcatgagc 58320
caccgtgtcc tgccgactga tttctaaaat atattaagcg acaaaaatga ggggcagagc 58380
agtataaata gcgtctattt gttttcaaaa agcgtggaag ttactgttgc atgacaaggt 58440
agaaaataaa aacatggaag agagaggaat ttacatatat atatgtaaag ataaacgtag 58500
tgtgttttag attacaactc ttagaaatta ttgatgaccc ccagagtgcc tttttttttt 58560
tttttttaga gatagtgtct tgctatatta cctgggctgg agtgcagtgg tgccatcttg 58620
gctcattgca acctctgcct cccgggttca agcgattctt gtgcctcagt cttctgagta 58680
gctgggacta caggcacaca ccatcatgcc cagctaattt ttgtattttt agtagagacg 58740
gggttttgcc atgttggcca ggctggtctt gaactcctgg cctcaagcaa tccatgtgcc 58800
tcagcctccc aaagtactgg tattataggt gtgagccacc gtgcctggcc ccaaagtgct 58860
tttgcttata taggttatgt gggttataat tacttatact taatcatatt aaaaatcaca 58920
actgagaaat ttagaatgtc tgtttaaaac cacattaggg ccaagtggga gaatcatttg 58980
aagccaaagg aggccagcct gggcaacata gtgagacctc atctctacaa aaacaaaaaa 59040
aaattaaccg ggcatggttt tgcatgcatc tagttacagc tgctccaagg gctcagaccg 59100
aaggctaaaa cagagaatca cttgagtgtt ggcccagatt ggcctcccag agcgttggga 59160
ttacaggcat gaaccactac acccagccca tcttggtctt tatttagaag tttgttgatg 59220
ttttgtggcc agaaatctgc cataggaact taactattgt ttagtatcag ttagcctatg 59280
gtaaaattgg tttccttgta tgttgttttg cttttgtaag ttgcagtttc aaagaacctg 59340
ttgatgactt taagtgagga cttaactgta acaatagtaa gcccattact tattgataaa 59400
aataacatgg tattatgaaa aataactttt ttttttttga gtcagggtct tgctctgttg 59460
cccagcctgg ggtgcagtgg catgatgata gcttacagca gccttgaact gctgggctca 59520
agcagtcctc ccacctcagt ctcctgaggt gctggaacta caggcacatg ccaccatgcc 59580
tggcttattt ttaaattttt tgtagagaca gggtcttgct gtgttgccca ggctggtctc 59640
acttctgacc tgaagcaatc ctcctgcctc aacttcccaa agcactggga ttacagacat 59700
aaaccactgt gcctggcctt ggaaaatgat tatttaaatt tttttttttt ttttagtgaa 59760
aagagttgca tcgctttaca tttttataaa tctctttaat gtctggctta ataaaattca 59820
gttcaattct catatatctg cctctgtatt cagtgtggaa atgtaaattc tagggaccta 59880
accccagagc tgtttagttt aaccctaggg atgggttcag caagttttaa caaactctcc 59940
atgggatttg gatacacact caaggttgag acctatggca ttgtgacata gcccacactt 60000
taaagtgaag tattatacca tgcagtgaga ttaggatgta atagaatata agaaatggct 60060
aaggataaat gggagagaca ctgataaaga taattttgcc tatgggcaaa agttaataat 60120
tagcagatct tccaaaagca tcagttaggt atttgttgct ttgaagtggg aagcagtgtg 60180
acagttctct gaagcaaggg caaagtgggg ataagggagt gtgtgtgtgt gtgcgtgcgt 60240
gtgcattgca tgtatcttac atttgtctta atgcttttcc tttgtaaaat gtgtaaattt 60300
tttttgattg ggttaattta attcacagtg tcatctgtct tcagttagaa ataatggaaa 60360
ctgagccatt gtttacagtg gaaaaacttt gaagctggta gtcaggaggc ctcactgccc 60420
taccttaact ggttaggttt cgcagcacaa tctttttttt aattgatgca taagagatgt 60480
atgtagtttt gcaggtaatt gcatgaatat ttaaggtatt attttttaat tcttaaatga 60540
tcctcttctc ccagataata gatgccactc aaaaaggaaa ttgctctcgt ttcatgaatc 60600
acagctgtga accaaattgt gaaacccaaa aagtaagttg aggtggattt agagtttgag 60660
gtatttgttc acgattgctg ttctgaccat taattttaga tcccatatct aaggtactca 60720
tgaatttttt agtccctttt tcctattcta ctttattatt taagatttta tttggaaata 60780
ggtttagatt tataggaatg ttagaaaaat agtattgact acacccatat atcagtcttc 60840
acctagcttt ccccatgtta acatcatata taaccataat aaaaggatca gatccagaga 60900
atgctattaa gtaatatgaa gaccgtattc caattttgac agctgttgtt tttctggtcc 60960
aagatccaat ccaggaactc acattgcatt tagttgtcac ctctccttcc ttgcccataa 61020
ttattttgta tattatttta atggtgccaa aatacaaaac taaattttaa ttttgaaagt 61080
tcagtgtgta tttggattct ttattaggtc ttatctaggt gcaacatttg acttttaata 61140
acactgatga gggactgaag gactaacatt gagagggatt gtatcttttt tttttttttt 61200
tttttgccca ggctggagcg cagtgacatg atctcggctc actgcaacct ccgcctcctg 61260
gattcatgcg attctcctgc ctcagcctcc caagtagctg ggattacacg tgcgtgccat 61320
cacgtccagc taattttttt agtattttta gtagagacgg ggttttgcca tgttggccag 61380
gctggtctcg aactcctggc ctcaagcgat ccacccccgt cagcctccca aagtgctaag 61440
attataggcg tgagcctccg cacccagctg ggattgtaac tttttaaggt taaagctatg 61500
aacccgctct gcaaatgtat atcattgatt tcctctcatg ttgaaatagc acttttgagt 61560
ctggatattt tttgcccttt gaactataca ctaatagatt ttatgcatgg ctcttccaag 61620
agccaagttg tataacaaaa aggagaacct actgtggaat cattcaacct aggttttggt 61680
tatagttctg ccagagctgg tggccacatg tctagctgtg agactctcac tgtacagtgt 61740
cccttaatct ctgcaagtcc agagttttca ttagtaacat gtgcaaattg tctggatcag 61800
agctcctcag tccttgactt gcttacatgt tttggaacta aaagatctgc ctaacatgta 61860
tctgccccca ttttaattct tgagtcttat gcatctgttc tgatgtccct ttcactatac 61920
tcagccagat gaccaccact tcatggaatt aaacttttgg gatcagtgtt tcctagtttc 61980
tatatctcat cttatcttac aacatggtta cttttaacat atgttaatat agacttgcct 62040
ttgatactca gtgacacaag catcctctgt ttgccaattt ttagtacaag tgaatcttta 62100
ctgtatggaa atgttaagat aaattaaaat agcagttact tttttttctt ttttttagca 62160
gttactttta ttagagacga attagagata tatgcaatct ggtagtccat taaatgagag 62220
ttacacttaa atattttagt tcttttaaag aaaaaagtct ccatgtgcta tttgggaaaa 62280
ccttcattgc ctaaagaccc acttgcataa ttaaggcaga tgatgatgat ctttatatat 62340
gcgcacacac acacacacac acacacacac acacacacac taataagtta ctaatttctt 62400
ttgttttcaa acatcatctc agtggactgt gaacggacaa ctgagggttg ggttttttac 62460
caccaaactg gttccttcag gctcagagtt aacgtttgac tatcagttcc agagatatgg 62520
gtaagtattg tttctactaa ttttgctgct tctgatgggg aaataggctg ttcagatata 62580
aggatataaa actttaatat aaattactta aaagttatat ttactcttaa ctcttatcta 62640
taagatattg ttttggtttt gtgtgttttt ctactgtatg acacttctga cccttaaggg 62700
atgttgtaca ggaactgtat aattttctcc tcaacttcat atggtctact tgtataatta 62760
tatttcttat gtaattctga aaaactttag acatgccaac tctttttgtg tctgaagaga 62820
atagtacagt attataaatt cctctgtatc cgttattcag cattaacagt tagcataact 62880
cataaccagt ctatttcatc tgtaccattt tgtactctta aatataattg gttacctagt 62940
tctttttttt tttttttttt ttttttttga gatggactct tgctctgtcg cccaggctag 63000
agtgcagtgg cgtgatcttg gctcactgca agctccgcct cccaggttca tgccgttctc 63060
ctgcctcagc ctcctgagca gctggtacta caggcgcccg ccaccacgcc cagctaattt 63120
tttgtatttt tagtagagac agggtttcac cgtgttagcc aggatggtct tgatctcctg 63180
accttgtgat ccgcccgcct ctgcctccca aagtgctggg attacaggct tgagccactg 63240
cgcccggcct ggttacctag ttctgtttcc taaaaacagt aaccgatgca atagcaaaga 63300
ctgcctaagc aaaaagtgtg agagttctta ttaacactga agcattaata aagatactga 63360
ggaggtttga agcacattat gtaaaatccc tgtgttctaa tgactactta aaaataaaac 63420
tacaggctgg ttgcagtggg tcacgcctgt aatctcagca ttttgggagg ctgaggcggg 63480
cagatcatga ggtcaggagt ttgagcctgg ccaacatggt gaaaccccgt ccatactaaa 63540
aatataaaaa ttagctgggc gtggtggcgc acgcctgtaa tcccagctac tctggaggct 63600
gaggcaggag aatagcttga acctgggagg cggaggttgc agtgagctga aatcgtgctg 63660
ttgcactcca gcctgggtga cagagggact ccatctaaaa aaaataaaaa gcaaacgaac 63720
aaaaaactac gcctgggagg ctgggtgcgg tggctcatgc ctgtaatctc agcactttga 63780
gaggccaagg tgggcagatc acgaggtcaa gagttcgaga tcagcctggt cacatggtga 63840
aaccccgtct ctactaagaa tacaaaaaat agccaggtgg ggtggcacat gcctgtaatc 63900
ctagctactc cggaggctga ggcaggagaa tcacttgaga tcgtgctact gcactccagc 63960
ctgggcacag agaaagactc tgtctcgaaa aaaacaaaac aaaaacaaaa aagcaaaaaa 64020
aaaaaaaggt atattagtca accaattcat gactttgaag actagtttaa aaataaaaaa 64080
ggaaaaaaat taagcattta aacatttatt ctgcctttct caagtgactt ctgctttagg 64140
ttaaaccaaa tagttgatga gaagaagttt ttctttgtac aagtcttcca gttaataaat 64200
gtagtagtag gtgagtggtg catgcttata gtcccagcta ctcaggaggg tgaggtggga 64260
ggatcacttg agcctaggac attgaggctg cagggaggca tgaccttgct actacagtcc 64320
agcctgggcc atagcacaag accctgtctc agaaaacaaa aagataaaac taaattaagt 64380
agtaaaaata tcaccatttt gcaacactta gtaaggtatg ggtcctaaac agtggtcatt 64440
agtggccgct aatatcagaa aaagacaact aatgtgtgcc tcataatgaa agaacacaac 64500
attacccgtg aaacagtcta tcttctttgg gtctttagga ccagtgacct atgcaagata 64560
ctttctgatt attaagaaac cagtacaatt aaaatattgg aaaatttaag taagatacaa 64620
aaccctaaaa gtttttattt tatttttttc agattatacc tatatcaatt agtagctttt 64680
ggtgtttatg ctagaaaagc acacagctgc agagtttcct gaatatttta attcttttaa 64740
tgctaccata tgatgaggtt ttaattcctg tactctgttc agtctggtga cagttaccag 64800
acttctggca atgaaggtct tttacatact ccttcacatt gtttcataca tgcttcatgt 64860
cttaaacata gtgaactctg aaactgatga tctgattata atctaggaca aatgccagat 64920
ggttgtttcc gattctgtct gcttctcttg tcagatattc agggcatgaa tgcagaccag 64980
gttctgtgtc gggctccatt tttttgcctc tgtgcttgta ttgtcctctc tgagggaaag 65040
aaaagtggaa atcaagtgct gtttgggaat tcctgctcta cttattgaac aatttatttt 65100
tatccctcta attgccacta tcatatccta agtccaccag tttactatta gaatactcaa 65160
ttattattat tattattttt ttgagacaga gtcttactct gtcacccagg ctggagtgcg 65220
gtggtgcaat ctcggctcac tgcaacctct gcctcctgga ttcaaacaat tctcatgcct 65280
cagcctcttg agtagctggg attacaggtg tgtgccacca tgcccagcta atttttgtat 65340
ttttaataga aatggggttt caccatgttg gccaggctgg tctcaaactc ctggcctccc 65400
aaagtgctga cattacagtc gtgagccact gtgcccagcc agtcttttaa taatcaaatg 65460
tttcctttta agtatcctgt attaatcatt ttatgtctgc ttatactaat gcatgtttgt 65520
ttgttctatg tgccaattaa acatttacat ataagtaata gttctctgaa ctatttaagc 65580
aattttattc ttaatccaaa catgtatatg atctcttatt ttcatattac taggtattct 65640
cataaaatgg aagaattgtt tatttcttgg ctagttttgt ctcccaaaga aagatgattg 65700
gaaaaataat gaatattttt aaagagcagt tttcagacat ttctattagt aatagcagac 65760
ttgttggaat ctcttcaagt tatggttttt gtttgtttga ttttgtttag actggtatga 65820
cttttgtgtg tattgccaac agttttgtat ggtttacttc cacatagctg acttctttcc 65880
tatgctcttt gaacagaaaa gaagcccaga aatgtttctg cggatcagcc aattgccggg 65940
gttacctggg aggagaaaac agagtcagca tcagagcagc aggagggaaa atgaagaagg 66000
aacgatctcg taagaaggat tcagtaagtt tgcatttttc tttcaacttt cacaataaaa 66060
aatttaaaaa gcgaggtggc ttttctgatt gaaggttata aagtcatact actgccacca 66120
gagaaatcca agatcagatg agttgttacc agaaaagaga tgcaattgct atttttattt 66180
cagattcata gagattggaa ttgggtactg agaactatta aagtattatt gaaaacacct 66240
ggactaatag tttttcagat tctttaaaac tcctaagtac aagtaaaaca tatcttttct 66300
ccctgatagc tcactatgtc tgctgtacgt ttctaatctc ttgttattgg tttgtctttg 66360
tttggtactc taaactttga gtgttcttca aatctctgaa aatcctcttt tgagtgtgag 66420
aaaagttttg agaggaagta ggtaacctaa gaccaacagg agtagtcaca gatgctcttt 66480
ttatttaatg aaacagcagt tgatagcctc attttgtacc ctgtcttgcc tgagttactc 66540
ctgggatggg gatgggattg ttggtgggga atatcctgtt actaaaggga ctatcaattg 66600
caaaaaggac tttgtgttta aaaaaatatt ctcctccctt ttttgaggat ccctttgcta 66660
gagcactgtt tttcaaaaat gtgatccttg gatcactttc tttagaacca gctggctgga 66720
tccatagtaa aaatgcacat ttttgggcta ctctctagac ctgtgaatct tagtggaagg 66780
gctgagggtt taccggtgtt agtcagcaaa ttcccctgtg attcttttgc agttagctca 66840
ttcctggact tttcaggaac ttaatactca taagaactat agatgacagc aatttttctg 66900
tttagatggg gagatagaaa aagacatgag ggaggtgatg agagtataat ggttaaaagg 66960
taacatcaat tgagcacaaa ttaatttgag ggaattaagt attaagaatc tgaattctgt 67020
aagaagattc agttaaaaaa agttaaaaaa agcattggaa aggtccgtta aaaaaagcag 67080
aaaaggacag tttatataac aaacacctgt atttccacca cccaacatga acaaatgcat 67140
tggaatgtca tgtgttcttt agctctttct ttctctctct ctcttttaaa aaatgtatat 67200
attttcaaat ggtttggctt tgtttttttt tgagacaacg tctcgcactg ttccacaggc 67260
cagagtacag tagagtgatc acagctcact gcagccttga actcctggct caagtgatcc 67320
tctcaccttg gcctcccaaa gtgctgggat tacaggcatg agccacagtg cccagccccc 67380
cttttttttt tttttttttt ttttttgagg caaaatctca ttctgttgct taggctggaa 67440
ttcagtgatg cattcatagc tcactgcagc ttcaaactcc tgggctcaag tgatcctctc 67500
gccttggcct cccaaagtgc tgggattaca ggcatgagct accacaccca gccttcagcc 67560
ctctttttag atagcatata tagtgtaact ttatgccaag cacttttcta agcacttgat 67620
gtattagctc atttaattct cacaataagc tcataaatta ggtaatgatc tttccttttt 67680
tacagttaag aacacactaa ggcacagaga gattatagtg tcacccaaat aggtggtgga 67740
aataagctcc aatccagcat cttgtctctg ctcttaacca ttgtgttaaa ctacagttaa 67800
actgtagagt ggagtcccct cctacctttg aggcaactat ggccataaca atagatgttt 67860
ctgcatttta gaacatattg ttttgtgtgg cattttaaaa gtttttagaa atggtaaaat 67920
atagctgggc gtggtggctc ttgcttataa tcccagcact ttgggaggcc aaggcgggag 67980
gatagcttga gcccaggagt gcaagaccat cctaggcaat atagtgagac ctcatctcta 68040
ttaaaaaaga aaaagaaatg agataatata gatgtatttg tgtgcatttt ttactcttat 68100
ttttgaattt gatctgtatt catatatgta gatgaacatt tatttctaat tgctgtaatt 68160
tttttctttt tttttctcaa cttctgcatg atggtcattt gaaagttttt cttttttttt 68220
ttcatcatgt aacagtttat tgacatattt tcctactgat ggatacttat gtttccaatt 68280
tttgctatta atttcaaagt tagtatcttt gcacatgtct cttttgcaca tgtttcttta 68340
agatttatct atggaagtgt agtcactggg tcatacctag tctgttagct ttcttcactt 68400
gactaccgga catttttctt taaactccat tagattgctt ttgttgttaa ctcttgtttc 68460
atataattca tggtttacca gagcaaccac aaagtagtta ttaaacatgt tgacctaaac 68520
tagtatctcc ataaaaactt tccaggccag gcacggtggc tcacgcctgt aatctcagcc 68580
ctttgggagg ctgaggcagg cagatcacga ggttaggagt tcaagaccag cctggccaac 68640
atggtgaaac cctgtctcta ctaaaaatac aaaaatttgc tgggcgtggt ggcgggtacc 68700
tgtaatctca gctactccgg aggctgaggc aggagaattg cttgaaccca ggaggcagag 68760
cttgcagtga gccgagatgg caccactgca ctccagccta ggctacagag caaaactcca 68820
tctaaaaaaa taacaaaaag aaaaacttcc caatggctgt ttcctatttt caaaacttac 68880
agaataaaca catttttaaa actaatttat tgatgagaag tgaccttact atggattaag 68940
aggtggcatt atatctgtat catacctcca ttaggtggct ttttaccttt ctgagaagat 69000
ttaaggataa ctctgaagaa ctaaggacta gatatttctg tcattggttg gttggttgta 69060
ttcaggtaat agtgtgccaa tttcaggata ggtcttagtg cctttggact gaattagatg 69120
taacttgtat ccagtcattc cataggctac agtcatcggt tgctccagat atgaatttga 69180
agttattccg gaacaatgat gttttatatg aaactttgcc cagatagagg aatatcccag 69240
aatgaaccta ggttcctaga atgatgtgaa agatcatttg cccttgactc taatgcagag 69300
gttaattgta ctttaatttt acttggatta tctgctgcag aaatttcttt tttgcatgcc 69360
tggattctga gttttggtca gttacagttg agcagaatca cagaagcaga atcacagaat 69420
tcaactgttt gaactcacaa ggttgagcct tgggaatttc ttgggtaaag gatgccatgg 69480
aaaggacaag atagctagca gttcagaatg cagttttgca tgtataaact gttgacaaga 69540
agatgttaat aatgattgca ctataatcca catccctcat gttacccctt gattgctaaa 69600
cattttttat ccttgttctt atgattgcat ctgtatacag cttctttcct taaccaaact 69660
ataagctctt ccaggacagg tgattatctt tggctatgtc acacactggg tacttaagta 69720
cttacttact tgatggaagt ataatatgtc cctactatga cctgatgtta tttgtagttt 69780
atggtacgaa cagaaaataa tctgaaactt cccttagtct ctattgtttg agtttttgaa 69840
acaaatcaat aataatttat gtaataaaga gggtgaaaac ccacctgagt gagaagaaat 69900
acttaacttt caactcataa caaatgaata ctactatcca gaatatgcat aatgagtgta 69960
actagtatcc tattaataag aaaagaacag ccagcacaaa agaaaaatag acaacttcca 70020
gagacacttt actaattgaa atagccaata aacgtggaaa gctgttcaac tttattagta 70080
attggggagt gcaaattaaa attactatta gatgttattt acactctcac cagattgata 70140
aaaattaagt tccatggtac ataagaacaa cagatctcat acactgttgg tgaggggtgt 70200
aaatgaggga caaccacttt tgaaaatact ttgacattat ttactgaagt gaaagaacat 70260
ataccatatg agccagcagt tcctgggtgt ataagcagag aggctagcta taatgtatat 70320
cagaagtcac aacagcattg cttatgatat cagaaaaagt agaaataact caaatattta 70380
ttaacataag aatgggccag gcgcagtggc tcatgcctat aatcccagca ctttgggagg 70440
ccgaggtggg cagatcacct gaggtcagga gttcgagacc agcctggcca acatgatgaa 70500
accctgtctc tactaaaaat acaaaaatta gccaagtgta atggtgggtg cctgtaatct 70560
cagctacttg ggaggctgag gcaagagaat tgcttgaacc caggagatgg aggttgcagt 70620
gagctgacat gatgccactg cactcctacc tgggcgacag agtgaagctc agtctcaaaa 70680
aaaaaaaaaa aaaggatgga taaattataa aagaaatagt catgaaaata aactggctgc 70740
atacagtaac atggataact cttaaaatgt aaggttgagt gaaagaagca tgacaaaata 70800
ttttgtccag tatgatttca tttccataaa gatagacaaa attttatata cctatgtaac 70860
aaacctgcat gttcttgcac atgtatccca gaacttaaag taaaattaaa gtaattaggg 70920
agcaaggaca agagtgaacc tttcatttct aataaagtta gcttccatca cttaaaaaaa 70980
attaatattt aggaatttgc atatggatag taaacctata aagaaaattg aagacctatt 71040
tcttaaaatg ttaggataag ttatctccaa agcataggaa gggttgctgt tataaccagg 71100
aaggggtagg tacatggggc actacaggaa tgctagcagt attctgtttt ttaaacttac 71160
ctggatggtg gctgtatggg tgttgctcac ctgtttatta aacctattta ctaattgttt 71220
ttatatattt ctgtctatat gtgtattctg catactgtat gttgtattcc atcaagaagt 71280
atttaaaatg ctacttagac cccttagtgc cacaaatatt caagtattaa aaaatagtat 71340
cttgcaatga ttaggtactt aatacatttt caagtactat agaattgtgc atatatatgc 71400
actatatata gtaaatatat actatctata aattacagat aaatatataa tgtataaata 71460
tatatttaat atatataaat tttcagttta tcaataattt aaaaatacac cctaatcatt 71520
cttacattta tgtttacttt tagttactta cctcatattc ttggatgatg ttgacccata 71580
cataaaatct aagactttta ataaatgtaa tttaattgaa aggaagggag acaaactcag 71640
tcttcccacc tctgtctccc aggtacccta aaagttattg cacaattgat tgctatgctt 71700
gagcacccaa aattagggaa gctgtattat caccactgga attggcatgc atttatgtgt 71760
atgtgtgtta cagtataacc gctgaggaat gttcaagggt tattcatctt tattttgttt 71820
gcaaaactta atttatactg cagtttctgc atttttacgg tttatttttc tttagttaga 71880
acgtgatttt ctttatatcc tggaaatgcc ttacacaata tctattcaat aaatgttatt 71940
gaatgaatgt aaataacata atttagagtt tttaaacagt cataacatgc ctaattttaa 72000
aaagaaaata cctctttttt tttgtttgtt tttaagagag tattttgctc tgtcacccag 72060
gctggagtgc tgtggcatga tcttagctca ttgcaacctc cgcctcccaa gttcaagtga 72120
ttctcctgcc tcagccatca gagtagctgg gattacagat gtgcatcacc acacctggct 72180
aatttttatt ttattttatt tatttattta tttttgagac agagtcttgc tctgtcgccc 72240
aggctagagt acagtggcac gatcttggct cactgtaacc tccgcctccc gcgctgaagt 72300
gattctcctg ccacagcctc ctgagtagct gtgattttag gcacctgcca tcatgcccgg 72360
ctaatttttg tatttttagt agagactggg tttcaccgtg ttggccaggc tggtcttgaa 72420
ctcctgacct taggtgatcc acccaccttg gcctcccaaa gtgctgggat tacaggcgtg 72480
agccaccgtg cctggcctaa tttttgtatt tttagtagaa atggggtttt accatgtttg 72540
ccaggctggt cccgaactcc tggcctcagg tgatctgtcc gccttggcct ctcaagtgct 72600
gggattacag gtgtgagcca ctgtgtctgg ctgaaaatat ctcatttttt agccctgtga 72660
atattttcgt ctcaaaaatc tgtcaaaagc agtattctgg ctgttacagt tgagggggaa 72720
agtagaattt taaagccctt gaactcatct aataccgtag aatttgggac acaggaaggc 72780
ttacatttag gatatgcaag gaaaagatat ctttaatgaa attgtctttc ttggattaag 72840
acaactttaa attggttttt ctgttcatgt atttactcaa aaacttaagt ggtattggaa 72900
atgaaaaaga atgagcctta aatgtacatt ttagaaagaa aaatgggttt gagtttctac 72960
aacctctctc aggcagcact ttattttttc tcatttattc ttgttcttta ccagaatgtg 73020
aatttttggg tacaatatga aataaaaatg ttcagtgcct tgcctgaaat tatattaagg 73080
gataaatagc tagttaagta aaagaaaaaa gtaatagaaa attttcttaa gattctttcc 73140
ttttagcttg cttttctctg aatcatttca ttctagactt tcatcatttc ctgctaagtt 73200
gtaatgttac ctgtcttctc cttagtctct agcttatctg aattttattc tgttattgcc 73260
gcacaaatta ttatcaagtt ccactttggg ctgggcgcag tggctcacgg ctataatcct 73320
agcactttgg gaggctgagg cgggcagatc acaagatcag gagatcgaga ccatcctggc 73380
taacatggtg aaaccctgtc tctactaaaa atacaaaaaa ttagctggat atggtggcac 73440
gggcctgtag tcccagctag tcaggaggct gaggcaggag aatcacttga acctgggagg 73500
tggaggttgc ggtgagctga gatccgcgcc actgcactcc agtctgggcg acagagcgaa 73560
actccatctc aaaaaaataa aaaataaaaa aataataatc cattttgatc atatatattc 73620
ccttgttcag gattctgttc aggttttatc aaattcaagt tattttatgt taaattgaga 73680
tcttctaatc taacaccagt cttttatttg tttgtttgtt tgtttgtttt tgagaaggag 73740
tctcactctg tcgctcaggc tagagtacag tggcacaatc ttggttcact gcaacctcca 73800
cctcgtgggt tcaagctatt ctcctgcctc agcctcccga tagctggtac tacaggctcc 73860
cgccacgatg cccggctaat ttttgtattt ttattagaga cagggtttca ccatgttggc 73920
caggctcgtc ttgaactcct gacctcaggt gatccgcctg tcttggcctt tcagagttct 73980
gggattgtag acatgagcca ctgcatctgg cccagtcttt tatttggtat ggtttttctc 74040
agtccgtcac catgccttac ctgtttgagc tttgttgacc taagcactgt catgatttct 74100
tattttcctt tgttcacact tttccccact actttgctta ccctttcctc ttgtctttat 74160
cttacctatt tctaatctta tttcagtgac tcattctaat tactccctta tgtaggcctc 74220
ttagttctat gtaacatttg cagttaatgc ttccttgttt ggtttcatat gaattaattt 74280
aatctcaccc ataataaatt ctttgaaaga atctttatgt cctgtaactg ccataatgca 74340
gggctggaaa taacctttgg taggttgatt cccacccccc gttatttaca tttaatattt 74400
aaaatactta aagaatatat atgttacaaa gcataattat aaaatccttg ttagtgcttc 74460
tctgcttcct tctccctacc tagaggttac cactgttgta cattttgggt cttacttcct 74520
tgcctttttt tgagacagga tttcactgtg tcacccaggc tggagtgcag tggcaaaatt 74580
ataactcact gtagcctcaa tttcccaggc tcaggtgatc cttctgcctc agcctcctga 74640
atagctgaga ctatagacac atgctaccac acctggctaa tttttttgat ttttagtaga 74700
gatgaagtct ggctgtgttg cccaggctgg tcttaaactc ctgagctcaa gtcatcttcc 74760
tgcctcagcc tttcaaagtg ctgagattac aagtgtgagc caccatgccc ggtcatcctt 74820
gcctgtttaa aagcagtttt tcacatatgt atcactaaaa agttcagctt tgaggtgcat 74880
aaaaatggat tcatatagca tgtaattctt tggaacttgc tttttcttaa tgacatattt 74940
ttaagattga tggatgttgt tgcatttggc tgtacttgat tcctttcact gtagtattat 75000
atttcattga gtgaacatgg ccgtttatcc aacttgtaca gatatttggg ttgttggcaa 75060
ttttttgcta ttataaatat tgcttcaatg aacattctta tgaatctcca ggtacacatg 75120
tgcagaattt ctctacagtt tattctgata agtagaattt ctgtgcatgg ggatacaact 75180
attttatttt tcaggctaat gctttatttt tttctgaagc acccggcccc tatcagctgg 75240
gtcattcata tgctgacatc ataaaaaggt cattatatat tataacatat aaattatata 75300
agtttgaagg agatatatct cacacagcag cgtgaaaacc cattcatcat atttatgaac 75360
cataaaggat ctctgaagtc cttttggttt aatgtaattt gttcatggtc tcccataagg 75420
gcaggttttt ctgttttggc tcattgcaga tctccaccta gaattatact tgactcatat 75480
aagttcttgc tacgtatttg atgagtgaat gaaatgcatt tcaaatgtat tataccactt 75540
tatactttca tcaacagtag acttgttatt atcagccttc ttaacttttt cccccagtct 75600
agtactttcc cagtttggtc ttcatttgtg ttttcctgat aattgataag gttgagcaac 75660
tttttgggtt tttggttttt ttttttgttg ttgttgtttt ataaaaaggt atttttattt 75720
gctgtggtag gtggatggag agctagaagc tctgatggaa aatggtgagg gtctctctga 75780
taaaaaccag gtgctcagct tatcccggct aatggttaga attgaaactt tggagcagaa 75840
acttacctgt ctggaactca tacaggtgaa cactttaatg tttgtttttt atttctggtt 75900
ttgtggtggg aatgaatgaa tgaagatgaa tgaagaagga ataattctga taagagttag 75960
tcttatttta tttatttatt tatttgtttg tttgtttgtt tgtttgtttg tttagatggg 76020
gtcttgttct gtcatccagg ctggagtgca gtggtgcagt ctcggttcac tgtaacttct 76080
gtgtcctggg tgcaagcaat tctgcctcag cgtcctgagt agctgggatt acaggcgcca 76140
gccaccacgc ccagctgatt tttgtatttt cttattagag atggggtttc accatgttgg 76200
ccaggctggt gtggaaatcc tgacctcaga tgatccaccc gtctcagcct cccagaatgc 76260
tgggattaca ggcgtgagcc accatggccg gccagtttta ttttttaaat ggatatgtga 76320
gttgtgtatg actttcaaag cttgtaccat attatttaaa atggctaaag agttcagtat 76380
catttaatct attagtacag ggatccccaa tccccaggcc atgggctgat taggaacggg 76440
gccacacagg aggaggtgag tgagcattac tgcctgagct ccacctgctg tcagagtagc 76500
agcggcattc gattctcata ggagcacgaa ccctattgtg aactgcacat gcgagagatc 76560
taggttgtac actccttatg agaatctaat gcctgatgat ttgaggtgga acagtttcat 76620
cctgaatcca tcccccaccc agtttgttga aaaattatct tccctgaaac tggttcctgg 76680
tgccagaaag gttggggacc atggcattat tagacctggt ttgctttctg tctatattca 76740
aagaatgtgg tggctttttt tttttttttg taataattca tcacacttgc catagccttt 76800
taccctccag ttactagcat cccaaagcca tttgtactac gtgatctcca agcacaaaat 76860
tttaacggta ccctttttta caccagttta ttaagtatgc cacaagatgt tagataacac 76920
aaaatgattt tttttttttt ttagggtctt gctttgttgc ccaggctgga acgcagttgt 76980
gcaatcatag cttactgcag ccttggaact cctgggctca agtgatcctc ctgcctcagt 77040
tgcctgagta tctaggacta caggcacaca ccaccacatc cagctaattt ttatatttat 77100
atttttgtag agataagggt cttgctattt tgcccaggct ggttttgaac tcctggcctc 77160
aaccagtccc tccctcttcc accttcgaaa gtgctgagat tgtagttgta agccacagtg 77220
taaaaaaacc atgatgatta aaaaaaaaaa actaacagga aaaagaggtc ttttcaacaa 77280
tcatctgaaa gggagagaag aaagaattat ttaaggacta atttttatgg ttttagcttt 77340
atttaaaaag ttagatgcaa ttttttctta gttcttcaga attttcatta taaatgacct 77400
attaatattc atataatttt ctacgttagt aaaatcccag ttgactggct gtattttgtg 77460
tatcagagaa gattataatc tgtttaaagc atttgttgta gagttctatt taggctaatg 77520
aaaacagagt ttctaggttt tttttgtgaa tgtaagtgaa ccctataatg tgtaacgtat 77580
acatgaactc tcctcgggct ctttgtaata ttctgatatt gcctcccaat gctctgcatc 77640
gtgtctccct tcccccatga aagaacacac actcacagtc ctgcctgaag tcctttctgg 77700
aacgtcatgg gctgtctttg ttgtggatct ggatggcaga gctaggtgac ggccgggaaa 77760
gtaaccagaa gcttcaggaa gaggtcagtt cacatttagc ttgcttgttt cttaaaactg 77820
ttatattgat tgcctcggtt gtggatatgt gataatatca gtaattatga atttagcact 77880
gtatcattgg tattaaataa tcaaataatt ttttcatctc agtatcattc ctttaacgta 77940
tctaaccgta catacacctt gttagtagtt tgtcccatgg ttttcctata gtatcttttt 78000
aaagttggta ctacatagca gggaactaca agagcaagat ataataacaa caacatagtt 78060
aagtgaaaga tccagtttgt tgttaaaacc agagttttaa aaagatggga agtcatataa 78120
aatttgaact gtggggtcta aagaattggt aaagatctga attctgcata acaagagtat 78180
gaacattttg aggaatcttt taaataagtg ttttaaaaga tctaagtaaa ggttcattgg 78240
cagcattatt agtggagtta cgatgtcttt acctttctat gaaattaata aaattttcta 78300
actttctaat ttgtaatata atcccagagt cttttattta ataaaacact tttaaaaaca 78360
aacaaaaagg aatgggcaga taagtacttg ttcttgcctc tgtccttctc ccaggagatt 78420
tggcttgagg aaattgagga agccttgggg tttctgtgga actacattga ggaatacttc 78480
agaaaaaatt cttggatttc aaaatggggg aggttgtcta agaatgagga ggggatctct 78540
ctttgctaga cagctgttta tcaaaagctg aagagatgtc tgcatttttg tgtgtatgac 78600
agacatcatt taaatatgtt gttacatagc tgctaagtgt atatcacaga cacttggtaa 78660
actttttaag aaaagatacc caggattggt ccagtagtgt atatgtttaa aaagctaccc 78720
aggtttagga actactggta gagaatatta atcagtccta tttgatgttg tgattcttgc 78780
tgatcagtct tattaaaagt ttttctttct taaggaaaac aatattatga tttttaaata 78840
tgcttgtgtt tacagagatg tagttcttaa taaagcagta gcaaaactgc actactcttg 78900
cagaaataat ctgagtccca tccagaaatt gaaaaagtca actgtaggcc aggcgctgtg 78960
gctcaatgcc tgtaatccca gcagtttggg aggctgaggc aggtggatca cctaaggtca 79020
ggagttcaag accagcctga ccaacatgga gaaaccccat ctctactaaa aaaaaaaaaa 79080
aaagctgtgc atggtggtgc atccctgtaa tcccagctcc tcgggaggct gaggcaggag 79140
aatcgcttaa accagggagc cagagattgc agtgaccaag atcacatcat tgcactccag 79200
cctgggcaac aagagcgaaa ctccatctca aaaaaaaaac aaaatcaact gtagccaggt 79260
gtggtggctc atgctggtaa tcccagcatt ttgggaggcc gaggtgggtg gatcacttga 79320
ggtcaggagt ttgagaccag cctggccaac atggtgaaac cctgtctcta ctaaaaatac 79380
aaaagattag ccaggcgtgg cagctagcgc ctgtactccc agctacttgg gaggctgaga 79440
caggagaatt gcttgaaccc aggaggcaga ggttgcagtg agccaagatc atgccattgc 79500
attccagcct gggtgacaga gtgagactct gtctcaaaaa aaaaaaaaaa agtcaactgt 79560
acaaagtgat gtaatttttt tttatgttta atcagattat aaagactttg gaacacttgc 79620
ccattcctac taaaaatatg ttggaggaaa gcaaagtact tccaattatt caacgctggt 79680
ctcagactaa gactgctgtc cctccgttga gtgaaggaga tgggtattct agtgagaata 79740
catcgcgtgc tcatacacca ctcaacacac ctgatccttc caccaagctg agcacagaag 79800
ctgacacaga cactcccaag aaactaatgt ttcgcagact gaaaattata agtgaaaata 79860
gcatggacag tgcaatctct gatgcaacca gtgagctaga aggcaaggat ggcaaagagg 79920
atcttgatca attagaaaat gtccctgtag aggaagagga agaattgcag tcacaacagc 79980
tactcccaca acagctgcct gaatgcaaag ttgatagtga aaccaacata gaagctagta 80040
agctacctac atctgaacca gaagctgacg ctgaaataga gcccaaagag agcaacggca 80100
caaaactaga agaacctatt aatgaagaaa caccatccca agatgaagag gagggtgtgt 80160
ctgatgtgga gagtgaaagg agccaagaac agccagataa aacagtggat ataagtgatt 80220
tggccaccaa actcctggac agttggaaag acctaaaggt aaggaagcat cttttgttca 80280
tttcaacttg aattactcag gtttagagtt ctacaaacct aagcaaaatt aactactttt 80340
tttagccatg catatttctg aaaaatggaa tactgtctct cttactgttt tatttataag 80400
tgtctcaaac atcctctaaa ccgtggcaag agtcatatta gccaaactaa tatacaaatg 80460
tcttcttttc tgtcacttag aaaagtacat cacaatagtg agttcagtca tttaagtgct 80520
cttcacatta aaaacaaaaa tcctttgagg agcaaactta ggattctatt tgtaatgaga 80580
aaaaattagt gtttaaattt attggaaatc agttgtatta atggaaaatt aaaaataatt 80640
ggaaaactaa gataatttag cagcttacta aaaatgattg aatgtaaatt tttattttag 80700
aaaaacaact ttatggaact agttcgtatt cacttctatt attgtttctg aaatgggcct 80760
gcttttaaat gcctatttct ttggacaaaa gaggaaaaat agatctggaa ctcttatgcc 80820
tattacatac ataatctctt gttgaagaat gtagcaagat gtgcagggtt tgctttgcag 80880
aaaacccaga ctgagtcttg gataaacaca agaatgaata acaggataaa cctaggagag 80940
gtgtggtaca tttcatttgt aagtgatctg gacttgggat ccacgtcttg aggaccctgt 81000
gggaacaggt tacttaacta gcttctattt ttctgttcct cctttcttct gccggagatg 81060
aagcaaccaa ataaaccagc aatcctgact ctttgcagca agatgaacac ctgaatcctc 81120
cctgccccta attatgatga caaagctcac tccattagat cctgtgattt gacccaatga 81180
aactggcctt aaacactgag caaaatgagt agttggtggt tgtgtactat gcttcctcat 81240
ttgctgtgtt gagacccttc tttaagtatg ttgtggtttc agcttttgtt tacccatttg 81300
agctcttact catgttactt tcatcactta caattcagta taaagtcagc cttattatgt 81360
cttaggaaat caggcctttt tctaaatatg aaaggaagag ttcgtagtaa atttacttat 81420
gaagtcagta tgtgaactgc aggaatcaga attgcagtta attgaaagaa gtgctgggat 81480
agtcacttga tggattttta tttaaggcct gctttgtgac agcacaggag tccctaaaag 81540
gagtccctct tgtgtttgga ggctgctagt ggagcctgta aagaagctca gttaagaagg 81600
tggagatgaa gacaagtaca caaatggaca cagaaaaggc ctttatagct gtacttttat 81660
ggaaggaaga ataagtaggg ttgtagacca gtagtttact tttgccggag aagtctctgg 81720
ttgatgttat tttttaaaac tgctaagaag taatcattgt aaagctatct taaaatctgg 81780
aaaaagtaaa tattcttgtt tcttcgtatg atagtgggtt tctgtaattg tgatggtatg 81840
aattactctc taggatatac ttaacccaat tagatgtaac catggtaatt taaactcaca 81900
ctctggacac acatttgagt cctacaaaat tatttcttcc ccttcttctt atcttcccca 81960
ctcctatctg aaacatcaaa gcaattttat atgtagcttg atgatcctct tgatttgagg 82020
tttaaaactt tatttgtact taaaatatat ccttcttatc cttcatactt tggatttttc 82080
ctgattctta gtgtcaaggg agccgttaag taaaattctc ctctcttctt caaactttag 82140
tttgctctgg aatcattacc catctagaat tgtattactg agaaatgttt ttacttgact 82200
gtgaactgtg atgttttgtt atacattggt gctggggttc ttaattcatc catcattcta 82260
attaacattt actatggctc tgttttcaaa actctgatta tggtggttct taaaaaaacc 82320
agacaaacat agatagcatt taaccagaag tctgaaatca ggaatccata atttgaacat 82380
gttttagaga aacacattga catgatgtga ttactgtata tccatacgat cccggcattg 82440
aaagagttaa ctacttctgt ctgacttcca cctatgtgtt cgagtagaca ttggctgaaa 82500
agaaaatgtc ttattcaacc aacctttatt aggcacctat tgtcaaacac tgtgttagtt 82560
gctgatcttt aattccaaga tcgtactaaa aagcattggt ctaagattgt ggttatgtgg 82620
ttatggccat ttcaagtctc cccagccaac cgggggccac cataacattg gtggacatgt 82680
gttccgcttg gcttttctac acactggatg gagtgaagaa cagaaaggga ttgcttcaga 82740
ttccttaatc ttggttttgc tgtgatggca gactatagga atcatcagta aatgaaagag 82800
ggtgggaggg aagggaatga agcttcatga attactcttt gtcctcccag atctgatgat 82860
gatccccctt gtaacttgaa ccatttccat ctagcttctc agggcagcaa ggagcttgtt 82920
aacatcacca gctgaccatg tgtctccttt tctcaactcc atttccaact tcgtgctgaa 82980
gaaaaacgag aacctagcgt gcattctgtg aagaaacagg aagatggttg ggaagttgga 83040
tgatgcatga aaaatataat aggtgaaaag aggacagagg tggttaactc actggcgccg 83100
gcgttatttt ggtgcgtcca ttgccgacaa tggatgtcgt tccgggaaaa tccctactcc 83160
tggcgagaaa ggattaagtg agctactttt tctataccta tatacacagg accactgcct 83220
tgactccaca aggcttacac attttgactc ctaaagtaga cctcaaccag aaacatcacc 83280
tagcacattg ccacttgtga gcatgtattc attttcatgt gaaaatttac taggctacat 83340
tttcagcagg gatatgtgca tatatttctg tttgcagaag aaattgttgc atatcaccct 83400
tcatgctgaa aatataccct agacttcata gggcaaaaca gctggttacc agtggtgact 83460
aagtgtaact tgactggaat atcttcattc atttggatca taagaagagg aggtaaggtt 83520
cctgtgaact tggcaatttc atttgccatt aaacaccgag agattgtaat ggttagtgat 83580
tccagagcct ctcttataaa cacttagatt ataggatgtg catttctcct tagaatgaag 83640
tctgggtatt tccatttgca tctggattta gatgatttag ggacaaaatt acctacatgt 83700
gataagttga actcttccta atgactattc ttattcttct cttatttcat ctttatctca 83760
agacattatc tttaattcag caaatcaagt atttccctag aaagctatgt attaaaactc 83820
tctatgaaaa gttaaaataa aacatagagt tgcctaaact gagaagtttt gagtcactgt 83880
ttggaatttc actccctcgc taatattgta tgtgaaatct gctgtgcaac atttgaaaat 83940
gaaattatgt ttcctggatt tctgtgataa tttttgaatt cttactagag taagattatt 84000
ctgtatccat aaggattaat attacttatc ctttaacaaa attagaattg cccctaaaga 84060
atgctgtttt agctacagca acattgaaat ttttaaataa atgtctcgtt tggtagaagg 84120
caaaaatggt ctaaaattta ttggtccatt ttttaaccaa atactttcat ctaaatcaag 84180
ggttggccaa atctgcccca ctgtctgttt ttgtaaataa aattttcttt gaaacacagc 84240
catgttcatt catttatgta ctatcatctg tggctgcttt tgtacttcag tggtagagtt 84300
gagtagttgt gagaaagact ggatggctca caaagcctaa aatatttact atcttgtcct 84360
ttacagaaaa agtttgccaa catctgatct aaaagataaa gtgcagaatc tggctgctct 84420
aaacattctg gttttgaatg aagtcatttt cactttactc ttttgggtga gctcttaatt 84480
ctgtttccct aaagacataa tgatcatgtt tctattgctg cccatgaaat tagttttttt 84540
aaaaaagtct tgatgctgtt taggaagtga tttggttgta caactatctt gagaggtggg 84600
agggtgtata cattatagaa tttccaagct agaagtgatc attaaggaat attgttattc 84660
ccttaggact gtgaccaagt cagaaacttg agactgtttt agtatagatg taggcagtat 84720
aatttaagtc ttatagtaac cataatgaaa acacatacat tttccttctt aatactttaa 84780
acttttaatt atgatataat ttcaggctca atgaaaaact gcaagaacag cattctgtac 84840
atattctaca tgttacacac attctagtga cgagtctaga gaaaattcag tgaaaaattc 84900
ctctaaactt ttcactgaga ttccccagtg ttaacatttt accttatttt ttttattgtt 84960
ttctgtttct gaactttaaa aaagtaagtt acagcagagg tgggcagatc atttgagccc 85020
aggagttcaa gaccagcctg ggcaacaaag caaaaccctg tctctacaaa aactaaaaaa 85080
ttagcgaggc atggtggcac atgcctgtag tcccagccac ttgggaggct gaggtgggag 85140
gattgcttga gcccaggagg ttgaggctgc agtgatccat gatggtgtca ctgcactcca 85200
gcctggatga cagagtgaga ctttgtgtaa aaaaaaacaa aacaaaacaa caacaactaa 85260
gttatagata tgatgcccct ggatattgtg tatttcctaa aaccaaggat attcttctgt 85320
gtaactttag tgtacttacc aaaatcagca aatcacagtg ataaaatact atgatctaat 85380
cagcagacct ctttcagatt ttgccagttg ttcacataat ggcctttata gcaaaaaaaa 85440
aaaaaaaaaa aaaaaaaagg ctgagaatct aatatgggag cacacattaa ttgagttgta 85500
tgtctcctta gtatccttta ctctgaaata gttcttcggt ctgcctttat tttttataaa 85560
gttcacattt taaagtattt ttgaattttt gtagaatacc ccgcagttgg gtttgtctga 85620
aactttcctt tgcttggatt caggtataca tttttttggt caggaatatt acagtagtgt 85680
tcttctcatg gtactgaatt gtcccattac tagcattgtc aacttttatc actcgattaa 85740
gcagtagtct gccagacttt tccagtgtaa agttacgatt tttcccttta taattaaaaa 85800
gcatcacata tgagcaactt tggaaatatg taaataccct atttttcata aaatgtatcc 85860
attagattta gcatccagtg atttgcttga attacttact gtggtggttg ccaaatggtg 85920
attttctaat tcattattcc ttttactttg tttattggac attctttttt aagcaagaag 85980
tttacttgtt ctcctatttg ttcattcatt gatttatact attttactca tagattctta 86040
ttttacccaa tagattataa tccattaact tcattattta cttgatgcct tcattgtccc 86100
atatttggcc agtagaagcc ctttcatgtt ggcttttgtg tcattctgac atatctccat 86160
tattttcttt tacctttttg ctacaatatg ctgttccagg ctcatcttgt actgtccctt 86220
ccccagcccc ggaattggtc atttcttcaa gaatctcttg ttcctcgcgt tgggaaatgt 86280
ttttgaaacc aatatctgga ttctagatga agttgtcgat actaggacag tgtttctagg 86340
acccgtcagt agattgtata aaatatatgt gtgtgtgtat caattaacat gtacgtacac 86400
acaatgtact tcaccactct attatctatc atttgtttcc atctgttaat ctgacaccat 86460
accctccttt gaatcttttg agattccttc tgtaactctc agttgttcat tcttcttttg 86520
cctgtccctt aaaaagttgt atttcttggg gtacctgaga tgtattttgt tctacatgtt 86580
aaatagggca cagcaggccg ggcgtggtgg ctcacacttg taatcccagc actttgggag 86640
gccgaggcag gtggatcacc tgaggtcaac agttcaagac cagcctggcc aacatggtga 86700
aaccctgtct ctacaaaaat acaaaaatta gccgggcacg atggcagtgc ctgtaatccc 86760
agctactcgg gaggctgagg agggggaatt gcttgaaccc aggaggtaga ggttgcagtg 86820
agctgagatt gcaccattgc actccagcct gggtgacaca gcgagattct gtctcgaaaa 86880
ataaataagg cacagcatct cttctttgcc acttttaatt caggctcctg ccatttctta 86940
cttacacttt tacaacattt atccttcttg ctctcattct tttccccttt catgtaaccc 87000
ttcattatgc tacagtattt taaaaacata gatgtgatta acaggaacct ctagtaacat 87060
ctcagagact ccattactct aagaacaaag cctttagtgt atgatagaga aagtaattcc 87120
gtatctgtct aaacttcttg cctagcaggc agtttctctt tacacactca gtgcatgagg 87180
cacatcagtc ttctcataca tattcacctc ttcatgtcct tgaacatact gttctcctta 87240
cttggaatac ttttttttct tttgaatgag ttgcagttca tgctttgtcc ttttctgtac 87300
ttctatacaa ctgtaattat cttaaccgat tactaaaact tcttgtgtag atgcttgttt 87360
cccctcacta gaccatggaa ttgctttctt caaaggcatg gacaattttt taatctttgt 87420
agtaagagtt acttttattg tggcatcttg gcagtaatgg ttattataaa ttacttctta 87480
ctaatagtga gtgactacta tgtgccctct ataatctgtg ctacattcag tagctagagc 87540
aatctttcgg aaatataaat ccttcatctc agtttcctat ttaaaatttt taaatggctc 87600
accattacac tgttgaaatt aagttcattt ttcttaacgt ggcttgcatg cctggccatg 87660
gtctggtttc catttatttc tgcagtctcc tctcaagcca ttgtagacag gcagtagacc 87720
tctgctgcta atattcacac acatacattc attcctgaaa actcttttgt tttggatgtc 87780
tcttctcatt taaatttctt ccttttcccc cccggaaagt ctttcctgtt tctccaagat 87840
agagtgtttg ttttgccctt tgtataggct ctcacaacat cttttccaat caaaggcaga 87900
taacatttta tagtggtaca ttgagtgaag gaagagactg cttatgtctt ggtcacttgg 87960
gtcttcccag tgtcctgtga agagcttggt aatgtagttt gacatttcaa aaatatgtga 88020
atgaaaatat gaagaaagtc catctttttc tgtggtaact tcatactttc tttcatactg 88080
cttctcgaat ccctagaaca tattttttat ttgatagatg gtcagaaaat attttcataa 88140
gcacattgtt atcttttcaa ccctgtgaag ttaagtggtg gtgtttttat cagctgtaaa 88200
gtggaatcaa acaggcccat gaggttgtaa cttagctttt aagtgacagc tgacaattga 88260
cttatgtctt ctgatttaaa tactgccttc ttccactcac ttttctggtc caaaaaataa 88320
ctatttctct gtcttttcta ggcagttcat gcaattgtgt ttctttggca aatacttttt 88380
agattcttct tttttttttt tttttttttt tttgagacgg agttttgatt ttgttgccca 88440
ggctggagtg caatggcatg atcttggctc accacaacct ctgcctcctg ggttcaaacg 88500
attctcctgc ttcagcctcc ggagtagctg gaattacagg catgcaccac cacgcccggc 88560
taatttcttt ttgtattttt agtagagatg gggattctcc atgttggtca ggctggtctc 88620
gaactcccga cctcaggtga tctgcccacc tcggcttccc aaagtgctag gattacgggt 88680
gtgagccacc gcgcccagcc tttttagatc attcttaatc tgcttctgat ttagaaacta 88740
taataagtct gaattcattc taatgtcata gaaaccattt tagtgttttg ttcaagtatc 88800
tttttttcct ttaatactgc agagattttt tttttttttt ttaagagacg gagtctcgct 88860
ctgtcgccca ggctggagtg cagtggcgca atctcggctc actgcaagct ccacctcctg 88920
ggttcacgcc attctcctgc cacagcctcc ggagtagctg gaactacagg cacctgccac 88980
cacgcccagc taatttttgt atttttagta gagacggggt ttcaccgtgt tagccaggat 89040
ggtctcaatc tcctgacctc gtgatccacc tgcctcagcc tcccaaagtg ttgggattac 89100
aggcgtgagc caccgttccc ggcctactgc agagattttt aatctgtgat ccataattga 89160
acttcaggag atgtttagaa cctctaaaat tacatgtaag actatagcat ttctggggtg 89220
agggtccata aatataagca atttctctaa caggggcgtg tatatatctg ggttgagaaa 89280
ggaatgaact gtggttcaaa aagtgtttct agatgatttg ggtatcagga gggctcctac 89340
tcttagcttt gtagtgaagg gtgggtaagg ctagaaaaga aggtggttgg gggaccaagt 89400
ttaaatagag gcagtgaact aggaggactt tctaggtatg gcacttactg aagaacaaca 89460
tttacaagtt gccttgtgag tagctatggt ctttaccaag aatacaccca taatgcacaa 89520
gagtctttgg tactatgcct aggacttttt ctgaggtatt ttatcttttc ttcttctttt 89580
ttagttttaa aaacaggcta tttctgcaca tgaggcaaaa tatgaaagac atacagtgaa 89640
atgtttcctc cctacccttg gcttccatct gatttccttg aggcaatcaa gcagtttctt 89700
gtgtagcttt ccagagataa tttatgcata ttatgcatat attttatttt ttaaaataaa 89760
attggcagca ttattcagct cctttttaat agaatgtgaa gattacttga tatcaattta 89820
taaagaattt atttttcaga actgcatatt attttactgt ataggtatgc cataatttat 89880
ttaatcattc tcatagccat ttaggttgat tgctttcttt gccttagcag caagtaattt 89940
tcacctaagt cattgcacac attcacacgt aggaatatgc atgttggcta agttactaaa 90000
aattagtgtt gttgagctac agtctgtgtt gtaattttga taagcattgc caaattgctc 90060
ttcatagtta ttatatcaat tcagctctca ttggcagtgt atatacgtaa gaatgagaat 90120
ttcaccaccc ctggccagca caagtactgt caagttttat cttggtcaga ctgataggca 90180
aaaatggaat attgcagttt tgatttaatt tttctcatat gtattaggta ttgaacatct 90240
ttctgtttgt atttcctact ttaagaactt tgttcatatt cttcacccat ttttcttagt 90300
ggctgaaaac tgcacagatc ttgttacctt tcatttcttc ggagccctgc tattcgaagt 90360
tagagtgttt cttcaggggt ttaaaagcat aaacaaaatt atttcattcc ccttttcctc 90420
ttctccctct cactcttttc ttcctctttc ccacccatgt atgtgatttt tatgaaaccc 90480
tccagacatg tatagtatct tctaatcaaa tctctttgac ctacttgcgc ttcccctcta 90540
ctcaggtgca gacttgctag gtcataatcc ttctgttttc cctttggccc tcttagcctt 90600
attgctcagt agtatttcat atttctttaa ttctggaaaa tttatctgct taattttgta 90660
aaatattttc ttctttccta gaatgccttt tacctgaagt tggcacctga acttctaggc 90720
tccatagctt tgcttttcta ctttcttttt atccattcct actgcgtttt gtctgttctt 90780
ttagctatga aagtgacagt ttactcacag tatttttttt tttttttgag atggaatgtc 90840
actctgttac ccaggctaga gtgcagtggt gctatcttag ctcactggaa cctcaaacct 90900
cctgggctca agagctccac ctgcctcaac ctcctgagtg gctgggacta taggcatggg 90960
ctgccatgcc caggtaattt tttcattttt cctttttttt tttctttctt tctttctttc 91020
tttttttttt tgagatggag tctcgctctg tcacccaggc tggagtgcag tggcaagatc 91080
tcggctcact gcaagctccg cctcccaggg tcacaccatt ctcctgcctc agcctcctga 91140
gtagctgaga ctacagatgc ccgccaccac gcacagctaa tttcttgtat ttttttagta 91200
gagacagggt ttcaccgtgt tagccaggat ggtctgaatc tcctgacctc gtgatctgcc 91260
tgcctcgtcc ttccaaagtg ctgggattac aggcttgagt caccgtgccc ggtcctaatt 91320
ttttcatttt tctagagacg aggtcttgct atattgccca ggctcctggc ctaaagcgat 91380
ctgcctgcct tggcctccca aagtgttggg atcacaggtg tgagccactg cacccaggct 91440
tgcttgcagt ctttttttct ctttctcagt attgctgtca tttaggaaaa tatttaggaa 91500
aaaaggtttg gttggcctat acgagatttg atctgtactt gttaacaagg aataactaaa 91560
tctagtctta gttttcaaaa ataaatctgt tattacagaa cagataatct gatctctata 91620
taacaaaagg tggaaatctt gcgcctgtaa attattttgt tctttttttt gagacagagt 91680
ctcactctgt cgcccaggct gaagtgcagt ggcgtgatct cagctcactg caagctccgc 91740
ctcccggatt catgccattc tcctgcctca gcctccccag tagctgggac tacaggcacc 91800
cgccaccagg cctggctaat tttttgtatt tttggtagag acggggtttc accgtgttag 91860
ccaggatggt ctcgatcttc tgacctcgtg atctgcccgc ctcggcctcc caaagtgctg 91920
ggattacaag cgtgagccac tgcgccccac caattatttt gttcttataa gtgttgttta 91980
gctcaggaac agtctaaacc agtggtaacc tttttcttgt cagaaaaaga tttcttataa 92040
attatttaat aattttgttt taatcctgtt tctacagtat atttttagag tttatttggg 92100
atgtattaat gaagtgctgc attgcttcca atgagtacct tttgagcctg tcataagaaa 92160
acgttgtaaa gtaagccatg tgacctggta gtagtaggta acttgttcaa gtgtttatta 92220
atagaaaaca tactatatgg aacatactat ttcgagttaa agactttcta ccttttactt 92280
ttatttgttt ttttttttct gtatgttttg tgtctgggca atctccagca gtatcactat 92340
atgttattgt ttcttaaatt tccccaaatt gtgatctttt gctttagcct gtttcctgaa 92400
tttcaaatgt atatttatca ctctgaccct ggaaacacaa tgttttgggc tgtaggtgag 92460
gcctttaaac agtagttctt tccagggata aaagcgtagg gtatatgcag tattttgagt 92520
ttatgtagca ctgtgtaggt gatttctata aattagaagt agaatttcac ttgttggtcc 92580
attcagaaag gaattgagtg ttgattatgt gccagacact gttcttggtg ctagagatac 92640
aataaagaat aagacagtat gggcccataa taattatagc ttgagtgtgt atgaattgtg 92700
tgttagttga ggtttgcacc tagacactaa agaaataaga ggacaatatg taaaaagtat 92760
cagatggagt gtggaagcag attcttttag gtctgtctga gggcaagagc agtcctagaa 92820
cctaacttac agaatatcaa acctgccagg catagtggca cgcacctgta ggccagctac 92880
ttgggaagct gaagatcaaa gcatcccttg agcatgggag tttgagggtg cagtgagcta 92940
tgatcacacc actgcactgg acatgatggc ttccagcact tcgggaggct aagacaggag 93000
gatcacttga ggccaggagt ttgagaccag cctgggcaac agagcaagac cccatcgcta 93060
tacacacata tacacacaca atattaaatc ttagaacatc cacagtattg tcttcagtat 93120
tctcttccag taaataacat tttgagacct tatagatctg aaaaatgtcc ttattctatt 93180
ctcccttgtt tggcagatca tataattatc attttgaaat cttctgttat agtatgccag 93240
tctcttgagt ggaatattta acaaagtaag gtgatcttac attaagggtt aacatgaatg 93300
aagccaattt aaacattttc tgtaacagac tctgtggcct atggatgtga cattattcca 93360
gacagactca agtatcactg agactaatac tattattcac aagacagaat gatcttaaga 93420
aatgtcaaag ttatcctcgc gtggctgctt ccttctcagc tttcaatgtt gtgggacttt 93480
ggaaaacttc agttgtattt tcaggacccc attctcttaa tatataaaat aaggaggaga 93540
cagtaggtaa tttgagttgc cagcttaaat tttgtatgta gccttgacta gaaagagaga 93600
ggatcaagtt agcagctcca agtgcttagg tacatattga tagaaattgt ttctcatgtg 93660
attaggcaca cagtaaatag tagctcctgg tcattagtca gtagtaatca ttattttgtg 93720
aacatcaaaa tacattttca acttagtagt tgatctaaac ttttgaacgt aactaagaat 93780
ttatctttga gaagcgtttc tggtggtaca ttaactgccg ctacagagtg ggtccccaac 93840
ttgaggccta tgtaataaat tactttaaat ttttgtaata aatgcttata atgccaagat 93900
attatgcaaa agaaactagg tcaaaattgt gttattctta gtgggaccct caatacacca 93960
attctaagta ccttttgtga atgaacctgc tgtcttttgg agtgcctagg tttacagagt 94020
acctaatgca aatgtcattt ccaagcttct taaaattagc agaatacctt ttttccctta 94080
tagtgtgggt agatggtaat aaatggcgtt cttacttttt cctgtctaat aacccctctg 94140
agaggcagac agaggagtaa gacacacaga actaagagtg ccagcttgct ccttcctgtc 94200
tttattcctg attcagtatt acccacagct agaaattgac aactcagtaa cttcagatgt 94260
ccctcatagt agcagatggg aatgtacccc ctctctaaag gcaaaagcag atcaagagaa 94320
aagagagccc agatgtctct tagctgaggg caggcctacc tagttttttc tcccagattc 94380
tctcttgtgg ggaggggtgg gtgaggataa gaatagccag tagttcagta gttctcagcc 94440
ttctctgtgc atcagaatca tctgaggagc ttctaaaaaa tacgcatgtc tggcatccac 94500
atccagagat ttagattcac tttgtctggg gtggtatttc catgaacgct tcttgggtgg 94560
tttaattgta caaccagggt agagaatcac agctctaatg aaagttcttc tacataggaa 94620
ggagaggtta aggggatgga ggatgtcacc tgcatttgtg cataaatctc agaatggtac 94680
tccttctcaa aataatgttg ttaggcatgt cctgtgtcat ctaatacaga agataaaagt 94740
gctcttgagt tagactgtct ggtagcatca taaccttggg tagattgcta agctttttaa 94800
gtaagtttcc tttttggaaa attgaggtaa tagtacttac ctcatagggt cgttttgaag 94860
ctcaaataag ataatgtatt tgaagggccg ggtgcggtgg ctcacatctg taatcccaga 94920
actttgggag gccaaggtgg gcagatcatg aggtcaggag ttcgagacca gtctggccaa 94980
catgatgaaa ccccatctct actaaaaata caaaaattag ccaagcatgg tggcatgcac 95040
ctgtaatccc agttactggg gaggctaagg agaatcgctt gaacctggga ggtggaggtt 95100
gcaatgagct gagatcgcac cactgcactc cagcctgtgc gacagagacc ccggttcaaa 95160
aaacaaaaca aaacaaaaag ataggccggg cgcagtggct tacgcctgta atcctagcac 95220
tttgggaggc cagggtggga agatcatgag atcaggagtt cgagaccaac ctggctaaca 95280
tggtgaaacc ctgtctttac taaaaataca aaaattagct gggcatggtg gtgtgtgcct 95340
ataatccctg ctactcagga ggctgaggca ggagaattgc ttgaacccag gaggcagagg 95400
ttgcagtaag ctgagattgt gccgctttac cccagcctgg atgacagagc aagactccgt 95460
ctcaaaaaaa aaaaaaaaaa aaaagatagt gtatttgaaa tgttcagcat gatatctggc 95520
acacagtata agtgcacaat taattataat catctttatt aatttgtcag catgcatata 95580
gtattggagg tttaaaaaaa tttttcattt atatagattt ccctggatct gtgcagtcca 95640
tattgatcct ttttaatggc aactgaatat tacatcatga cctttcctca gttgtgtgac 95700
atgtggctta ttatttttca caaatattgt gagaagcaac aattgtggag aggaggccac 95760
aggtgtggtt aatattatga gattcctctg aagggatgat atcaccttat gtactattga 95820
gagtgtgtag gcttgttact gtcccactta agatgactgg ataagaaagt attgtgccca 95880
atagttactc gatggacggt ggaatagtga agagctgtta aagaacaaaa taggttctag 95940
gccttagata acacaagaaa aggtacttaa aagcctttaa aacagttcac atttctcagg 96000
atcaattttg gtacagtgat caagaggagc agtgatctaa tgcttatcct ttatattttt 96060
tattttttat aacaaacaca atgtgaaagt agatattaca ttggccatta gtcatgttgg 96120
ttttgcattt atagaaaaat acactgaata gtaggaattg tctttacaca tacaattttt 96180
ctgaagtgtt tttatataac tgggtagtta ttaacctttt ctttctctaa gtagagatgg 96240
caagtgcaca ttagaattat gaatacttgg ccaggcatgg tggctcacgc ctgtaatccc 96300
agcactttgg gaggctgagt agattgcttg agcccaggag ttcgagacca gcctgggcaa 96360
tgtgataaaa ccccatctct acaaaaatag aaaaaattag cggggcatgg tggcatccac 96420
ctgtggtccc agctacttgg gaggctgggg cagaaggatt gcttgtgcct gggaggcaga 96480
ggttgcagtg agccgagatc atgccactgc ccttcagcct gggtgacaga gcaagacctt 96540
gtctcaaaaa aaaaaaaaaa aaaaaaaaaa agatgctcag gaagcgtatc cttgcccagt 96600
catttagtat gctgctttgc tagtgagatc gtacaagctt gatagatgta aatatatgta 96660
tttctgctat atattttttc ttgtttttaa ggggccagga tatattctta tttaaagccc 96720
agatataagt caaattttag agaataagta ccagcttgtt actttccatt tctttattgt 96780
catgtgaaaa cagtcagttt caaagcaatc accatttcca ccctcactaa taaccctccc 96840
tctggtttat tttttgcagg aggtatatcg aattccaaag aaaagtcaaa ctgaaaagga 96900
aaacacaagt aggtattcag agatactctg tgttgatggc tttacaaata ttcttttgtt 96960
atgtgcagag gtaactgata agaacttaag cgtttttgtt tttgaaacta gagaatatat 97020
aactaggtaa atgaaatatt tggtgtaaaa gtttggaaac ttgtgctttt attcttaatg 97080
cattttgcca aaggaaatgt ctcttacact gttttgttgt cgctttcctt gaactcagtc 97140
tttactagct ttttttctat tcgtttgtcc tctagagcag acattcttta ttttttttat 97200
ttagtctttt tttcttttat tattgtgatt ttgatttttt ttttccttcg caccagatag 97260
agcagacatt cttaaaccta tacttctaga tgtctttggg agggtcttta cctcaagata 97320
tttatatgca gctgggcagg gtggctcaca cctgtaatcc tagcactttg ggaagttgaa 97380
gcaggtggat tgcttgagcc caagagtttg agaccagcct gggaaacatg gtgaaaccct 97440
gtctctacaa aaaatacaaa aatattagct aagtgtggtg gtgtgtgcct ataatcctaa 97500
ttaccaggag gctgaggtag gaggatcacc tgagcctagg agattgaggc tgcagtgagc 97560
catgatcgtg ccactgtact ccagcctgag caacaaagtg aggccctgtc tctaaaagga 97620
aaaaagatgt ttacatgtaa aattctgtat gtacacagtt gacccttgaa caacatagga 97680
gatacagata ccctgtgcgt cgaaattcca cataactttt gactcctcat attatgtatg 97740
ttatgtgtat tatgtaactg tattcttaaa ataaagtaag ctagataaaa atgttattaa 97800
gaaaatcata agagaaaata tatttactct tcattaagtg gaaatagatc atcatagagg 97860
tcttcatcct tatcttcacc ttgagcagac tgacgaggaa gaagagggat tagtcttgct 97920
gtcttgggtg gcacagttag aagaaaatcc acatataagt ggactttcat ccagttcaaa 97980
ctcatgttgt tcaagggttg actgtattta cttttctgag gcaagttcaa aactttgatc 98040
agattctcag tcacccctga aaaagttaga atcattgttt cagaatggat agcagggagg 98100
ccatgggaat ctggtttctg gactttacca cttagttaca tttccaacaa acttatttat 98160
tgatttattt tttagagaca gtgtcttatt ctgtcatgca ggctgagcac agtgacacca 98220
tcatagctct cactgcagcc ttgaactcct gggctcaggc aatcctcttg cctcagcctc 98280
ttgagtagct gagactatag gtgtgtgcca ccatgcctgg ttatttattt atttatttat 98340
tttttgtaga gacagagtct cgctatgtta cccaggctag gcttgaactc ttgtccttaa 98400
gtgctcctgt ttccacctcc caaagtgctg ggatcacaga tgtaagccac tatgcccagc 98460
cttaagaatt tccttccttt cttccagcac acttacttag agattcaagg aatagggtca 98520
cttatggtgg ttattggttt catgagtacc tccaccactg acccactaaa agtagaatga 98580
agaagccagt gtgatttttt ttttttgtct ttttattttt ggtgtgcata actttttata 98640
taatcttagt cttattggtt aaagacctgt gagataacct ttgcaccatt gtttgtcttt 98700
cgaatatttt tagttccact ctctggttta gtctcttcat agcctcacat tctacttagg 98760
gctgcaaata actcttccta taaaaaagaa ggcaggactg ggcaatagtg gttggcaaaa 98820
ccagtggcac cactataggg ttgattatca gaagctagct ttctgggatc actgagttaa 98880
aactattagt agcacacaag caaagcttaa atacctatga gcgtttctcc ataatatttt 98940
gtaaatatct agtctggtgt ggctagatat ttgcaaatta ttgtggagaa atattttgca 99000
tccatgagat gcagaggatg atctgtaatg aacaactata tcttttcagg gagtagcctc 99060
ttttctgccg accttagtct ctctttcaca tgtagaaccc ttcatctcag tctcaggttt 99120
ctaaaataag aaaatgctta taatatataa tgcttataat tattttatat ttttatatat 99180
tatattattt tatatatttt atatatattt acatatatat aatatatata agcctggttt 99240
ccatttctta atgtcaaaca aagcatagaa cctttaaaat ttggaaggat tgtgaaacac 99300
ttcaggaaat acgtagtcta actttaccct catttttata atattaggaa atcagcctga 99360
ataaatggaa tgacttgtct gcctcacata ttctaaggtg cagagtcaga atatgaactg 99420
ttggtatgat tccttttttg ttttatcagg gtatagtgaa gaaatagtca cattttaagg 99480
aaatttatac taggtaagaa acctgggttt gcaggaggaa gcaagataga cgtgggtaga 99540
tccagatgca actggataat ggtacctcat aaaaggatat agtgctaata ccttgtgaac 99600
tggagcactt aatttaatta tactgcattt tctacccgga tgtggtacaa atgagttctg 99660
ttagcttctt gttgacgaat gctcatacct ggctgtagtt tagtaaccat gttgcaaata 99720
cttggggttt tgggccacct aaaagaactg tgagaaatgc ttatgaaacc taactcggtt 99780
gctgagggag taaaacaacc catagaacat ttttatgaga tgagaaaaag aaaaagcagt 99840
aaatgtttat tgagactctt ccttgtccta tgagagaaat tctcaataag agagcaatac 99900
taacatacac aaagcaacag catattatgc cagtcaattg atactgaaat gtttagtggt 99960
gagatttagt agttgttgtt tttttttttc ctcccgagat ggagtctagc tctgtcgccc 100020
aggctggaat gcagtggcgc gatctcggct cactgcaact tctgcctccc gggttcaagc 100080
cattctcctg cctcagcctc ccaaatagct aggattacag gcacctgcca ccgtgcccag 100140
ctaatttttg tatttttagt agaggagagt ttttactgtg ttggccaggc tggtctcaaa 100200
ctcctaacct cataatctgc ccgccttggc ctcccaaagt gctgggatta caagcgtgag 100260
ccacagtgcc cggccgagat tgacttctta aggagatgag aaactaggag gtgtgatcag 100320
tgaaaagtag tacttaggac agctttggag agcactggaa tggaattggg taagtgaaaa 100380
cagtgagatt aagaacgatt ctaggtaaag agagacactg taaattaaga aggttattaa 100440
taccatcttt gaataggaag ctggcattct gattttttgg tttgtcggtt tgttttttta 100500
agagacagga tcttgctctg ttgcccaggc tgaagcgcag tggtgtaaac agagctcatt 100560
gcagcctaga atgcctgggc tgaagcagtc ttcctgcctc agcctcttgc aagtagctgg 100620
gactacaagt gtgtgccact atgctcagcc tggtattatg tttttttaag atgtagctct 100680
ctggctttga tgacttccaa agttatcacc tgggtttgat atattttcct tttatattta 100740
tacctttgac tcttgaacaa cacaggtttg aactgcacaa gtccacacat acagtggatt 100800
tttttgtcaa ccaaatctac atagaaaata tagtattcat aagatatgaa accagcctat 100860
aaggaggggc aactttttgt atatgtgggt tccgtgaggt ggattgtggg acttgagtat 100920
gcacagattt tggtatggag agaagggggt tcctggaacc agtcccccat ttataccaag 100980
agataactgt agttcattaa aatgttgcct gataagccac ttttttaatt ttaagagatg 101040
gggtcttgct tcgtttgccc aggctggact gcagtggtgc aatcatagct cactgctgcc 101100
ttgaactcct gggcttaagc aatcctccca gctcagcctc ctaagtagct gggactacag 101160
ccaccatgcg tacctttaaa aaaaaaaata aacttttctc attgaggttc ttatgcttag 101220
cacatcaggc tgcttttcta tagattataa atatgaagag ttatagggta gttgaaggct 101280
tttacatttt tgaactggca agtaaactgc cttgctaaat gtaatgggaa tatcttgcat 101340
gcatgtgctc acagaactta ttatagaaat gttaacggct tagactgagt ctttggaggg 101400
aaagaggaga aaagggcatt tgtgaaagag acttttagtg agtagagtga acacagacat 101460
aagaccttgt atctctttca aattcagaac tgggtagatg acggaggagt ccatagatac 101520
atttgttgga tagaagtttt attatacagt tgatacattg tcatgatgga gaaaagtcca 101580
ccaaataaac ttaaaaaaaa aaaaaacaaa caaaccaccc ttttccctta gcaactgaac 101640
gaggaaggga tgctgttggc ttcagagatc aaacacctgc cccgaagact cctaataggt 101700
caagagagag agacccagac aagcaaactc aaaataaaga gaaaaggaaa cgaagaagct 101760
ccctctcacc accctcttct gcctatgagc ggggaacaaa aaggccagat gacaggtaag 101820
tggcctgtgt gagttttttt gtttttgttt ttgttttgag caagttaaaa agtacccaag 101880
tcatatactt ctgattgtga acatcaaggg cttttggaat tagtatttgc attttgatga 101940
gtgagtatac aactttactg ataatcttaa gacagattct ctgttgacag tagtagtagc 102000
tgtgaagatt aataggtttt gattcttgaa tggctcctat ttgataatat ttaaatgtcg 102060
ttttgggagc caaagatttg ttctttcgag cgcaatgggg gttggtggga gataagtctt 102120
caaagataat ggttattctt taaaagctag aactttgttt tcttatgagt tttgtgccat 102180
actaattaaa atgctgattt ttaataaatc tagtcagaag ctctcttgtt atgctggtag 102240
aaaaacaaac catgtaatcg tttactggag gctagaaaac atttatccca gacaagttct 102300
ttttaaatta aatttgcttt ttaaaaaatt gagataaagc atttatatac tgcatttggc 102360
agaatttttt agttttaaag tatctcggta tgtaatgtga tttttatttg cattccccta 102420
attactaaat agattgaaca tcgtgtcatg tatttattgt ccatttcttt ctttggcatg 102480
tagttaccca gttttctcag caccatttat tgaaaatgtg ctgtcctttc cctactgtaa 102540
ggtgctgtcc ttgaaaaggt gctgtccttt ccctactgta agttcttggt gcctttgttg 102600
aagttgagtt ggtttataaa cgggtggatt tatatctgca ttctctattc tgttctgttg 102660
gtctatgtgt ctgtttttat gccagtacca tgttgttttg gttactatag gtttgtattg 102720
gccatttctg tttcctgttc tgtgaagtat cttttttttt gagacagagc cttgctctgt 102780
tgcccaggct ggagtgcagt ggcatgatct cggctcactg caagctccgc ctcccgggtt 102840
cacgccattc tcctgcctca gcctcctgag tagctggaac tacaggtgcc cgccaccatg 102900
cccggctaat ttgttgtatt tttagtagag atggggtttc accattttag ccaggatggt 102960
ctcgatctcc tgacctcgta atctgcctca gcctcccaaa gtgcgggatt acaggcatga 103020
gccactgcgc ctggctgttc tgtgaagtat cttatatgtg ttgttcattc attgaattat 103080
ttgtcttttt tagttttatg tgtcctttat attctaaata taattttgtc ttggtgataa 103140
ttgttgcaaa tatcttctcc cagtttacgg cttgtatttt gacacttttt gtaccttttg 103200
atacatggaa tttattaatt atggtttagc tgaatgtgtc atatatggta tgttttcttt 103260
atggtttttt aaattgtgtt tttagaaatc ctcccttgag gaggtgattt tttttgtatt 103320
ttaagagaat taaatcctta atccatttgc aattaatttt tgtatatatt ataagggagg 103380
gattcagttt tatttaatac ccaattgtcc cagcaccatt tacttgaaaa cccatccttt 103440
tcacttgtct gcagtggtgc ctctctccca caaattttca tatatgggaa gatctctttc 103500
tggggctcat gatgactgta gcttctatta ggtcttggta gcaaatcact actgccttct 103560
tggttttcct ctgggaaatc ttgtcttttc tcagactttt actcttcttt aaaatctgct 103620
tccttagaac cctacccacc aaagagatga ttctgtagcg acttgacatt gatacaattt 103680
tgagtatgct tatctctgtc taatgaggtc tctgttgaga cagggtctta ctctgttgcc 103740
caagctggag tgcagtggca tgatcatggc tcactgcagc cttgctttac ctgcaccagc 103800
tcaggcagtc ctcccacttc agcacccatc cagtagatgg gactacaagg aagtgccacg 103860
atgcccggtt tttttgttgg tttttttgta gagacggagt ttctccattt tgcccaggct 103920
ggtcttgaat tcctgggtct cgaggctggt ggatcaccta aggtcaggag ttcaagacta 103980
gcctggtcaa catggtgaaa ccccgtcttt attaaaaata caaaaaatta gctgggcatg 104040
gtggctcatg cctgtaatcc cagctacttg agaggctgag gcatgagaat cacttgaacc 104100
caggaggcag aggttgcagt gaggtgagaa cacaccatgc actccagcct gggtgacaga 104160
gaaagactgt ctgaaaaaat aaataaataa aatgcataca gttttgtaac caccaccaca 104220
atcatgatac agagcacttc catcacctta aaaaattccc agccaggcgt ggtggcttgt 104280
gcctgtaatc ccagcacttt gggaggccga ggcgagtgga tcatgaggtc aggagtttga 104340
gaccagtctg gccaatatgg tgaaacccca tctctactaa aaatacaaag attacccggg 104400
tgtggtggca catgattgta gtcccagcta ctcgggagac tgaggcagga gaattgtttg 104460
aacccgggag gcagaggttg cagtgagctg agattacgcc actgcactcc agcctgggtg 104520
acagagcaag actccgtctc aaaaaaaaaa caaaaaattt gcggccgagc gcagtggctc 104580
acgcctataa tcccagcact ttgggaggct gaggcgggcg gatcacttga ggtcaggagt 104640
ttgagaccaa cctgaccaac atggtgaaac ctgtctctac taagaataca aaaattagcc 104700
aggcatggtg atgcacccct gtaatcccag ttactgggga gactaaggca ggagaagcac 104760
ttgaacccgg gaggtggagg ttgcagtgag ctgatatcac accattgcac accagtctgg 104820
gtgacaagaa tgagacaacc tctcaaaaaa aaaaaaaaaa aaaaaaaaag gccaggcgtg 104880
gtggctcaca cctgtaatcc cagcactttg ggaggttgaa gcaggcggat cacgaggtca 104940
ggagatcaag accaacctgg caaacactgt gaaaccctgt ctctactaaa aatacaacaa 105000
caacaacaac aacaaattag ccaggcatgg tggcgggcac ctatagtccc agctactctg 105060
gaggctgagg cagaagaatg gcatgaaccc ggggggtgga gcttgcagtg aacagagatc 105120
gcgccactgc actccagtct gggcaacaga gtgagactcc atctcaaaaa aaaaaaaatt 105180
cccctgtgcc cctttgtagt cagtcccttc cacatcccta actcctggca accactgatc 105240
tgctttctga ccctctggtt ttgtcttctc cataatgtca aaaaagtgat atatagtata 105300
tagcatttga atttgccttc tttcacttgt cgtattgcat tttagattca ttcatctatg 105360
ttattttgtg tctcggtagg ttttttttta attgctgagt agtccattgt attcatgtac 105420
catagtttat aaattcatca tttcagagac atttggctat tgtgaatgtt gctgctatgt 105480
acaagtctta tgtgaatatt ctccctcttt gtgttttttt tttttttttt tttttttgag 105540
acggtgtctt gccctgttgc ccaggctgga gtgcagtggc gtagtctcag ctcactccca 105600
cctctgcctc ctgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac 105660
aggcacacac caccaggccc agctaattgt atttgtagta gagatgggta tttcacaatg 105720
ttggccaggc tggtcttgaa ctcctgacct caggtgatct gcctgcctca tcatgcctgg 105780
cctctccctc atttttgaaa ggaagttttt ttggggaaat agtttctctc aacattctga 105840
ctctatttat tcttcagttt tctggcttcc cttaactggt tttgtgagac ttggtctaat 105900
tttcatcctt ctttaatcgg gcttttctct tggtctgctt ttaagaggct ctctttgtat 105960
atgtctttct gctgtatgtt tttatgagga tttctttttc ttttcccagt tggaattcat 106020
tggacttttg aatttgaagg ttatttttca actatttctc ttcatatcta atctcctgct 106080
taaccgtact gtggaattta gggacaataa attggattga gtattggatt atttcttggt 106140
ttatgacact tattttgttt tttattttaa ttttagaatt tgtgattata gaaatgtccc 106200
cagctataaa gaataggatg ctgtatctat ctttaatctt aaaattctag aaactaaggg 106260
tagagatgaa attagagatg aaattatttt catctctttg tcaattcctt gggattctgt 106320
tctgtgtgca agacaagctg agtaattttg agtatagttg taaaccagtg ccaaataggg 106380
tttgatgtgg ttagtggttt agtcatgagt gacataatac ttattagtgc tttgattgtg 106440
tctatgattt agggagcaac tttttgtggt ccttattttc tttctagata tgatacacca 106500
acttctaaaa agaaagtacg aattaaagac cgcaataaac tttctacaga ggaacgccgg 106560
aagttgtttg agcaagaggt ggctcaacgg gaggctcaga aacaacagca acagatgcag 106620
aacctgggaa tgacatcacc actgccctat gactctcttg gttataatgc cccgcatcat 106680
ccctttgctg gttacccacc aggttatccc atgcaggcct atgtggatcc cagcaaccct 106740
aatgctggaa aggtgctcct gcccacaccc agcatggacc cagtgtgttc tcctgctcct 106800
tatgatcatg ctcagccctt ggtgggacat tctacagaac ccctttctgc ccctccacca 106860
gtaccagtgg tgccacatgt ggcagctcct gtggaagttt ccagttccca gtatgtggcc 106920
cagagtgatg gtgtagtaca ccaagactcc agcgttgctg tcttgccagt gccggccccc 106980
ggcccagttc agggacagaa ttatagtgtt tgggattcaa accaacagtc tgtcagtgta 107040
cagcagcagt actctcctgc acagtctcaa gcaaccatat attatcaagg acagacatgt 107100
ccaacagtct atggtgtgac atcaccttat tcacagacaa ctccaccaat tgtacaggta 107160
actaattctg aaacttttct tttctgcttt atggtctgtt catgggatgt tagttaaatc 107220
tggtataggg gaggaagtct taccatggac tacttgtata tattgatcaa ctttatatgt 107280
attggttatc tattgtgtga aatattgcca gaacttgtca gcttaagaca ataagtaact 107340
cagaagcagc ttagcagggt ggatctggct cagggttttc catgaaatta cagtcaagct 107400
gttggccatg gctgcagtca tctgaaggct gaactagata tagagattca ctttccaacc 107460
tactcacatt gttgttagca ggcctccatt tctcccaagg gagaaccctt catcatggta 107520
atatttttgt gttttctaaa aatcatggtc aggccaggcg tggtagctca cacctgtaat 107580
cccagcactt tgggaggccg aggtggacgg atcacctgaa gtcaggagtt tgagatcagc 107640
cgggccaaca tggtgaaacc ccatctctac taaaaaataa aaaaaattag ccggccatgg 107700
tggctcatgc ctgtaatccc agctacttgg taggctgagg caggagaatc gcttgaaccc 107760
aggaggcaga ggttacagtg agctgagata gcgtcactgt accccagcct ggacaacagg 107820
gcaagatgcc atctcaaaat aaataaataa ataaataaat aaataaataa ataaataaat 107880
aaaaatcatg ttttcttttc tttttttttt tttttagatt atacaaggca gaactttttt 107940
tttttttttt tttttttttt tttttgagac ggagtctcgc tctgtccccc aggctggagt 108000
gcagtggcgc gatctcggtt cactgcaagc tccgcctccc gggttcacgc cattctcctg 108060
cctcaggctc ccgagtagct tggactacag gcgcccacca ccacgcctgg ctaatttttt 108120
tgtattttta gtagagacgg ggtttcgccg tgttagccag gatggtctca atctcctgac 108180
ctcgtgatcc acccacctcg gcctcccaaa gtgctggtgg gattactgac gtgagccacc 108240
gtgcctggcc ggcagaactt ttttttattt tttattttat tttaagagat taggtcttgc 108300
tctgccaccc gggctggagt acagtgatgc gatcatagct cactacagcc ttaaactcct 108360
gggctcaagt gatcttccca cctcccaaat agctgggact acaggtgtgc atcactgtac 108420
cctgctaatt tttttaagag atgcggtctc actgtgttgc ccaggctggt cttgaactcc 108480
tggcctcaag cagttctcct gccttggccc tcccaaagtg ttgagattac agacgtgagc 108540
cactgtgcct ggccagcagt acatttaaag ctttgaaaaa aaaatgttca aagcattatc 108600
atcaccacat ttctgtctct ctcccagcac tcctcattac cccttaaaaa tgaattattg 108660
tggatgttga agactcccaa caatgtttcc tgcacataat acttagtatt aaacagtaat 108720
ttttacttct gttcatattt tcataatgaa gctgtattaa aacatttgtt aaaatggcca 108780
tgacaaggta tcctgtttta attactaaaa ccctaactgt attaactact ttcatttttt 108840
atgatccttt aaagcaagtt ttatgtattt tatatatttg tcttgacttg aagtttttta 108900
tcccatgttt tcctacttaa aatgattttt ttttaagata gtaagtcaga ctttatttaa 108960
gaggagccag tggggataag tatggggacc actgtgatgg gatcttggag taggggaaag 109020
agatttgact caattcctta aaatgatttg taaccacttt ttcaaattat ttactattat 109080
actatatgtg tgtgtgtaca tatacatata catacataaa tgttttaatg ggtataatac 109140
cctatttgct tatatagtca tccattttac tgggggtagt catttaaatg aaaagttatt 109200
tttcataatt ataaatagca ttccattaaa catgcttata gtttttttct gctttttgtt 109260
tgctgtttgg tttaaaatga ctgttgttac agaaggctag taaaaatgtg ggcattattg 109320
gtcatcaggt gtgaattgtt tgtgtgtgtg tgtagggaga gagtatgttt cattctccct 109380
cctacagaat gttttgggtt ttggttttgg ttttgtttta ctgtcagttt gacttgggta 109440
tgagccatat tctttcttgg accaagccat tagttttgag tttttcccta aaaatatgta 109500
tcagggatac agtaaaaatg gtttatgtct atccccattc ctattcctga aataggtccc 109560
atctcagtac tagagcctaa gcaacagcaa tgaaagatat ccattaaaga ctcctcagta 109620
aagagctccc tggtcatatg atttttctta taaaataaaa tccatttatt ccttcccaat 109680
gagaaaaaaa gattctcttg gttttattca ttagccctaa gagccaagca tcacaattta 109740
cttgcttcta gtctttcatt ctgtccctat caagaagtac ttactgattc cctaatctac 109800
tttgtgtgta cttaagtagt aggtaaatgg gctgtggtgg ttcaactatc cttccgttcc 109860
ccactgtgtg agattaattg atcagatgat actgggcttt gggggtattg agaaacatag 109920
aatatattgt tagtatgtgt tttgagtcct ggtttatcat ttactgtgca tcctagaaac 109980
aggcattaat attcttgagt ctttgttttc tcatctataa aatgagcaga atgcctcaga 110040
atggtttgat ttgcattaag ataagggata ttaataatga tagattcaaa gcaccatata 110100
ccttgatggt tacttacaca aatagttacc ttaatagtat tcaggggaga ttattgacat 110160
taatgggctg tgaagtaaca tctggtcatg ttcatccatc tgttgtctag ccctaaaaat 110220
ctgacctcta ggagccttga agtttgtgtt gttgaagccc agtgttaacc atacaacatg 110280
gctactcaga gtttgcaagc tgtgataacc ttggcggtga agtaatatgt aacatgatat 110340
aatatacatt tacgtctgtg tatctacata ttcagtatct ttaatatttg gagcaaatgt 110400
gttatcagag gtgactgatt tttttacaca actgcatact aaacataaaa gctcaatttt 110460
aacagaggtc acgtaatttg tagtggtctt gtgacactaa taagtgactt actctcacaa 110520
agttatacaa aattacatct caagagtttg agtgcttaga ctataatttt tcattttagg 110580
ttggtgcaaa agtagtcatg gcttttgctg ttaaaaatgg tgaaaactac ttttgcactg 110640
acatagtata aagtgaagtg atccagatat aaagtaataa tgatttttta ttattctaga 110700
ggtggtaaca gaaaaattgt atttttctct ctataaccta ttggaccttc tcacatttct 110760
tctgtaattc ccattagaaa tcacatttta ggccgggcat ggtggctcac tcctgtaatc 110820
ccagcacgtt tggaggccaa ggtgggcaga tcacctgaag tcaggagttc gagaccagtc 110880
tggccaacat ggtgaaaccc atctctacaa aaatacaaaa attagctggg catgatggtg 110940
ggtgcctgta ataccagcta ctggggaggc tgaggcagga gaatcatttg aacccaggag 111000
gtggaggttg tggtgagcca agattgcgcc attgcactct agcctgggag acagagcgag 111060
actctgtctc aaaaaataaa aaaaagtcac agtttaaaga tacttctagt gggtatatat 111120
ttgagaaact agcattcgtg taacaatttt tttttatttt tggagacaga gtctggcttt 111180
atcacccagg ctagagtgca gtggtgcaat ctcgactcat tgcaacctct gcctcccagg 111240
ttcgagattc tcctgcctca gcctcactag tagctgggat tacaggtgtg caccaccatt 111300
cctagctaat tttttgtatt tttagtagag acagggtttc gccatgttgg tcaggctggt 111360
ctcgaactcc tgacctcagg tgatccacct gcctcggcct cccaaagtgc tgggattaca 111420
ggcttgaacc accatgcctg gccacatttg tgtaatttta agtcatttga atgagtgggc 111480
tctttaaatg tgatacaggt ttttcagccg ggcgtggtgg ctcacatctg taatcccagc 111540
actttgagag gctgaagcag gaagatcact tgaacccagg agtttgaaac cagcttgggc 111600
aacatagtga gaccctgttt ctacaaaaag taaacaaaat tagccgagtg tggtggcaca 111660
tgcctgtggt cccagctatt tgggagagct gaggtgggaa gattgcttaa atccaggagg 111720
ttgaggctgc agtaagccga gattgtgcca ccgcactcca gcctgggtac aaaaaaacga 111780
acattcatgt ttttctgtga tacagaaaaa acaaaaatct cgtataggtt tttccttagc 111840
aaatagaaaa gtcacatgat atatgtacat gtgtcaacaa acgtgtatat cttctgcatt 111900
attccagtca aactggttta tagaaaccaa attaatactg ttaaaagcct agaagtctag 111960
gcttttaaca taagtagata ctgctgttgt tatctcccag ccaacatttg gaagtgttct 112020
tctaaaccac agctttattc catatgaatc aaatactagt gtctgcataa tgagccttac 112080
ttaaacatcc ggtcttgtca gaaaaattct tcatgaacat attgtcactg atggccaaag 112140
aaattttgtc ttccaaaata ttagcagttt tctattgtac atttggatga ttgacttcct 112200
ggtcactcta gaaataacat gttttaccct ggtgattttt tttttttcaa aactagaatt 112260
cgaactagct tttttattat tttataaaat caatatcaga atattaaatg ttcacactca 112320
aaatatgtta ggtaattatg aaacccattc tattccaaat aagtgaagat accagtagta 112380
ggaaatgaag tcaaagaagt tacaataggg tcttaggggg agctttaaaa ggatttttgg 112440
ttgttagact gagtaatgtg gaaatccact ggagcagtta gaattgaata gcgtgatctg 112500
acatattttg agaggatcac tggctgctct gggtaaaaga gattgcagga gtcaagggca 112560
aaagtaggag actggccagg catggtggct catgcctgta atctaagcac tttgggaggc 112620
tgaggtggga ggatcgcttg agcctagtag tttgagatca gcttggttaa catggcgaaa 112680
cctcatcttt acaaaaaata caaaaattag ttggatgtgg tggcatgctc ctgtagtccc 112740
agctactcgg gaggctgagg caggaggatc atctgagccc aggaggtcaa ggctgctgtg 112800
agccttgatg gcaccactgc gttccagcct gggtaacaga gtgagacctt gtctcagaaa 112860
aaaaaaaatg tagggagaca aataatggtc atggcaagag aatatggtca cttgcacatg 112920
gtatgagtag agggataaga aaataggcca ggtgcggtgg ctcacatcta taatcccagc 112980
actttgggaa gccgaggtgt ggggatcact tgaggtcagg agttcaagac cagcctggcc 113040
aacatggtga aaccttgttt ctactaaaaa tacaaaaaaa ttagctgggc ttggtggcgc 113100
acgcctataa tcccagctac tcaggagact gaggcaggag aattgcttga acacaggcag 113160
cagaggttgc aatgagctga gattgcgcca ctgcacttcc gcctgggtga cagagtgaga 113220
ctctgtctca aaaaaaaaaa aaaaaaaaaa aaaagagaga ggaaatgtat acaggttgag 113280
tatcccttat ctgtaatgct tgggacctga agtgttttgt atttcggatt tttttcagat 113340
ttgggaatat ttacgttata tatacttagt ggtagagcat ccctaagtca aaatccaaaa 113400
tattccagcg agtatttcct ttgagcacca tgtggacgct caaaaagttt catattttgt 113460
agcatttggg atttctgatt agggaaatca gaaatgttta tgctcagcct gtacataaat 113520
acaatcatgt gccatgcaat ggcgttttgg tcaacaacag atggcattta tgacagtgat 113580
cctcgtaaga ttattatgga ggtgaaaaat tcttctggcc ttctgacatc ttgatgatcc 113640
tgactccgtg taagcctagg ctagtgtgtg tgtttatatc ttagtttttg tttttttatg 113700
ttgatacata ataggtgtac atattttcag ggtacatgtg ataatttaat atattcatat 113760
aatttgtaaa aatcagtgta ttgagatatc catcaccata aatatttgtc ttttctttat 113820
gctagaaaca ttcaattatt ctcttctagc tattttgaaa tatacaataa gattattcta 113880
aaatatagat accttactga tctatgaaat acttggtcat gtttcctcta tcaaaatgta 113940
tgtttttccc atatatatat atgtttatat atataagaaa cataaattta tatatataag 114000
aaaaacatat aaatatatgt acaaatatat aaacttatag aataagttta tatataatat 114060
ataaattcag aataagttta tatatataat atatactata aactcagaat aaatttatat 114120
attatatata atataaactc agaataagtt tatatatata atatatataa tataaactca 114180
gaataagttt atatataata atataaactc atagaataag tttatatata taatatataa 114240
tataaactca gaataagttt atatatttaa tatataatat aaactcatag aataagttta 114300
tatataggcc aggcgcggtg gctcacacct gtaatcccag cactttggga ggctgaggcg 114360
ggcggatcac aaggtcagga gatcgaggcc atcctggcta acaaggtgaa accccatctc 114420
tactaaaaat acaaaaaatt agccaggtgt ggtggtgggc acctgtagtc ccagctactc 114480
gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg gagcttgcag tgagccgagg 114540
tcgtgccact gcactccagc ctgggcgaca gagccagact ctgtctcaaa aaaaaaaaaa 114600
aaagaataag tttatatata taagaataca tatatatata tatatatata tatatatata 114660
tatatatata tatttagaaa acttattcta taaaaaactt atagaataag aataaggata 114720
taaaaaaaat atttggccca gtgtgttgtc tcacatctgt aatcccagca atctgggagg 114780
ccaaggcagg agaatcactc aaacacaaga gttcaagact agcctagaca acatagcgaa 114840
accctgtctc tacaaatttg tttttaatta gctgggcgtg gtggcacata ctcgggaggc 114900
tgagatggga ggattgcttc agtccaggag ttcaaggcta cagtaagcta tgatcacact 114960
actgcattcc agcctgggtg acagaatgag actctttttt aaaaaaaata taggccaggc 115020
acggtggctc acacctgtaa tcccagcact ttgggaggct gaggtgggca gatcacaagg 115080
ttaggagatg gagaccatcc tggccaacat ggtgaaaccc cgtctctgct aaaataaaaa 115140
aaattagcca ggcgtggtgg cacgcacctg tagtcccagg tactcgggag gctgaggcag 115200
gagaattgct tgaacccggg aggtggaggt tgcagtgagc ccagatcgca ccactgctct 115260
ccaccctggc gaggaggagg gaggagggtt gtttatacag ctgtagaatg tgtttgtatt 115320
ttaagataag tgttataaaa gagttaaaaa gttgaaaaaa tttgtttata aagtaaaaaa 115380
gttatagtaa gttacagtta atttattaaa aaaatgttaa taaacttagt gtagcccaag 115440
tgtttatagt ctacagtagt gtacagtaat gtcctaggcc ttcatattca ctcactcacc 115500
actcacttac tcaaagcaac ttccagtcct gcaagctttg tttatagtta gttccctata 115560
caggtgtacc atttaaattt tgtttttttg agacggcatc tcgctctgtt gcccaggctg 115620
gagtgcagtg gtgccatctc ggttcactgc aacctctacc tcctgggttc aagcgattct 115680
tctgcctcag cctcctgagt ggctgggact acaggtgcat gccaccatgc ctggctaatt 115740
ttttgtattt ttagtagaga tgggatttca ccgtgttagc caggatggtc tcgatctcct 115800
gacctcgtga tccgcccact ttggcctccc aaagtgctcg ggttgcaggt gtgagccacc 115860
gtgccccggc ctaaaaaatt tttatactgt atttttactg taacttttcc atgtttagat 115920
acacagatac tgttaagtta tagttgctta caagtcttta ttacagaaac atgctgtaca 115980
ggtttgtagc ctaggaacaa cagactatac catatagcct aggtatctaa tagatttgtg 116040
aagtacactg tatgatgtgt aagtacctca tacacttagt aggtttgtga aagtacatta 116100
tatgatgtta ccacaacaat gaaatctcct aacaatgcat ttctcagaat gtacccccct 116160
tgttaagcaa tacatgactg tacattttcc tctcaggctt tgtgatacta ttctgatggt 116220
aattctgcct taacaattaa tgtttttcag tctggtttat tatccaagta gattaagctg 116280
atccagaata ccaaattaag tgttcttttc ctttttcctg tgtcctgtca gtaattattc 116340
attcagaaac ctgctagata gctgcattgc ctattcagac tacttgagtt tttactggtg 116400
tcatttggaa ttatattttg tattttgagt acttagcatt tgatgtttct gtaatcattt 116460
tacctgctag aatctcagtc cataggagca aaatctctcc ttaagcacag gatacatgtc 116520
tattcaattc cttaacagtc accacctctt aggacagcaa ggctattttt cagtcttctt 116580
atcacctctt cttatttaag cagattttct atgcttgaga aataattaca gagtaggttt 116640
aagccctagc atagtactta tttcttatga aactccaggc atgggcagta cctggttttg 116700
atggtggtca gcactaaatg agatgatgta tgttaagggg cttcttgcat catagaacac 116760
tgtataaatt ggtgtgttgt gagaatttca gatgcattga ttctgctttc tgccaagggg 116820
ttttatcata gaagactaca aaaagctaaa acaaaaggta gcttaaaatt tgatcatctt 116880
atttactatg attcacaccc tttgaccttt tctgatccaa acaacctgtt tgttattaca 116940
agttggtagc aaaagccttc ctgaaaagag cagcgtggca ttgtttcttg gatatcccag 117000
gagcagcact tcattggttt ttgcttatag aaactgtcca cctgtttaat tttcaatgtc 117060
attccaatgt cattgaaagc taaacagttg gagaatttct atgaccaaaa aaaaaaaagc 117120
ttttattttc ttatgataaa gtaaaatcaa agtaagtaaa tgaataggga attagtaaaa 117180
aaagaaactt tggggtttga aacaaaaaat tgttttgcac atttatgtcc aaatatataa 117240
acaaaaaatt ttaaaatgtt atgggtatat ctttaagatt gtgccaactt ggaagtcagt 117300
ctgtttatta aagtgacaaa agcttaaatt attgatttct tcattttatc ttttagagtt 117360
atgcccagcc aagtcttcag tatatccagg ggcaacagat tttcacagct catccacaag 117420
gagtggtggt acagccagcc gcagcagtga ctacaatagt tgcaccaggg cagcctcagc 117480
ccttgcagcc agtaagaaat gtttcagttg ttaaaactca ttggctgtct actttgtctt 117540
tggaaggttt tctttttggt ttggatttgt tttgggtttt atttttgggt ttttttttca 117600
cgtgttcttt gttttatttt attttatttt attttttttt tgagacagag tctcgctctg 117660
tcacccaggc tggagtgcag cggcacaatc ttggctcact gcaacctcca cctcctggtt 117720
taaagcgatt ctcctgcctc agccacctga gtagctggga ttacaggtgt gtgccaccac 117780
gcctggctaa ttttgtattt ttagtagaga cggagtttcc ccatgttgac caggctcgtc 117840
ttgacctcat gacctcaggt gatccacccg cctcagcctc ccaaagtgct gggattattt 117900
ataggcatga gccaccacgc ccggcccgtt tttaaatttg tgtagccacc aaattcacct 117960
gagccaccct gagggcgtga actcaaccat tttgtaaaaa aaaaattttt ttaattctgt 118020
ggaatttata gttccgttaa tacatatttt gctccgcacc tgtagtccca gctactcagg 118080
aggctgagac aggagaatgg cgtgaacctg ggaggcggag cttgcagtga gctaagatcg 118140
cgccactgca ctccagccca ggtgacagag caagactcca tctcaaaaaa aaaaaaaatg 118200
ctcctaggat cctttttatt tgttgtttac cctgaccttg tatttttata ttttactatg 118260
aatttttgaa gtaataattt tttttttttt ttaactctgt cacctaggct ggagtgcagt 118320
gacacgatct tggctcactg caacctccac ttcctgggtt cgagtgattc tcctgtctca 118380
gcctcctgag tagctgggac tacaggtgtg catcactgca cccagctaat ttttgtattt 118440
tttttttttt ttttttttaa gagatggagt cttgctctgt cgcccaggct ggagtgcagt 118500
ggcatgatct cggctcactg caagctccgc ctcctgggtt ctcaccattc tccggcctca 118560
gcctcctgag tagctgggac tacaggcgcc cgccaccacg cctggctaat ttttgtattt 118620
ttagtagaga cggggtttcg ctgtgttagc cacgatggtc tcaatctcct gacctcgtga 118680
tctacccgcc ttggcctccc aaagttctgg gattacaggg atgagccact gtgcccaacc 118740
ttaatttttg tatttttaga tacggggttt caccatgttg gccaggctgg tcttgaactc 118800
ctgacctcat gatccgcccg cttcagcctc ccaaagtgtt gggattacag gcgtgagcca 118860
ccacacctgg ccgaagtaac aatttcctag accagctatc tatcagtatt taccgcgtac 118920
aggttgagta tcccttatct gagcttcacg ggaccagaag tatttcacat ttcagaattt 118980
tatggattct ggaatatctg cactataatt accacttgag catctctaat ttgaaaatgt 119040
atagcttgaa atattccaat aagcatttcc tttgaacatg gcctttgagt gtcatgtcag 119100
cactcaaaat gttttgtatt tttgtattag ggctgcttaa cctgtactag aatatgatac 119160
tgtactagtc accatggact aggcatgtag aattgtgtga tatacttcac tatacatgtt 119220
gtacaatgtt taaaaaaagt tttttatatg atgtttaata ttaagataag cttttggtat 119280
tctgcaacat atgtaggagg atatggtgaa atctcaaagt gttgttgttt ttggataaag 119340
tggaaaataa gaggttggca tgggaaacaa ctgaaaaaac taaacagaat agcatggtca 119400
aatcagcact ttagaacacc tacagttctg gagaaagctc ttgcagcaat ccagcaattg 119460
atgatgactt tagacaggac agttagtgaa gatggactaa aaatactata tgtgaaataa 119520
caggataata agataatgtg tacttagagc agatgtttga gtgcttgtta cgagttgagc 119580
ccttctaggc cttttttttt tttttttttt tttttttttt tttttttttt tttgagatga 119640
agtcttgctt tgttgcccag cctggagtac agtggtttga tctcgcggct cactgcaacc 119700
tccgcctccc aggttcaagc agttctcctg cctcagcctc ctgagtagct gggattacaa 119760
gtgcacacca ccacacctgg ctaatacttt tgtattttta gtagagacag ggtttcacta 119820
tgttggccag gctggtctca aactcctgac ctcgtgatcc acctgcctcg gccttccaaa 119880
gtgctgggat tacaggcatg agccactgtg cttggccgac taggcatttt taatacaaac 119940
ataaataagt ttccatttgt attcttaaaa gctgatcttt caaataagag agatgatgat 120000
cacaagagaa agatggtgac tacactaaaa ataaagtttt gtgttgggaa taagtactga 120060
atggtttgga atatatattt tttctttttt gccttaaact attaagagat aaatggtttg 120120
gaatattaag ggacacagaa gcttggggaa aagaggtcac tttataagct aaaggatagg 120180
gtaatggagg aattgaaact taagctgggc cagaaaaccc cagctgggtg aaataagaga 120240
taaaaaagag tatacacaaa gcaagaatgc tcaaagaccc gtgtttgctt aaaagtgaac 120300
acattttatc tgagcctggg gtcttcaggt tcctctttaa ctgtgcaagc aaaggtaaag 120360
gtaaaaaatg tattcttcat taataggctt gaaagaagga acaagtatat atccttgtgg 120420
tgattactag tctgctaggg ctgcggtaac aaaataccac agactgagtg gattaaataa 120480
cagaaatttt ctcacagttc ttgaggctgg aagtccaaga tcaaggtgtc agcagtgttg 120540
gtttctcctg aggcctctct ccttggcttg caaatggctg ccttcttgct gtatatacct 120600
tttctctgtg agtgtcctct ggtgtcagtt ctcttttaat aaggacacca tcctattaga 120660
taaaaagtcc tcactctttt gacttcatta atcttaatta gctctttaca ggccctgtgt 120720
cccagtaaca gtcacagcag gattagagct tcaacataca tgttttgggg aaacaaaaat 120780
cagtccataa gtgattatga ggtttttatg tttttcagaa tgtggcacta atattttata 120840
gttttgaggt ttcaagtacg gaaaaaatat aatggataat gttaacattc tgtcatattt 120900
gcttctcagg gggttttttg gtttttcttt tttttttttt ttaaagataa agatatttct 120960
gtatcccatt tagttaattg gtatcctgca gttgatatgc cttagaattg gtgttttaaa 121020
gttgaaaaat gctgctctat atgataaact atatggtatc ttggatggta aacttagagc 121080
caactgtcaa ttttctgata gctctgtaaa cctctttata tatactgtcc cttatttccc 121140
agactgtacc tttcctttat ccttttttta agaggaggta gatgtacatt tttacatatt 121200
taagtgggct attttgtcct attcagccag attaagagag agatcactga tcaaaaatgt 121260
gtgtgttttc tttgtagtct gaaatggttg tgacaaataa tctcttggat ctgccgcccc 121320
cctctcctcc caaaccaaaa accattgtct tacctcccaa ctggaagaca gctcgagatc 121380
cagaagggaa gatttattac taccatgtga tcacaaggta agaggagctg tatgggcgtt 121440
cccatgtctg cttttactta atcaaagaag ttgccactat aaggggagtt ttacagttgt 121500
aaacttcttg tcattagctt ttcactgtgc ttgaaggctg ctggatttcc agaatcacat 121560
cttaagtgta ttttagacgt tagactttgg ttctttttgt atttgttttg gtgtattttt 121620
attttattta ttttgtcacc caggctggag tacagtggtg tgatctcaac tcactgcaac 121680
cttctgctcc catgttcaag tgattctcgt gcctcagcct ccccagtagc tgggattaca 121740
ggcatgtacc acaatgcctg gctaattttt gtgtttttag tggagacggg gtttcaccat 121800
gtatgttggt caggctggtc tcgaactcct gacctcaggt gatctgccct gcccgccttg 121860
gcctcccaaa gtgctgggat tgagcccctg cacctggcag ttttggtgta tttctaatct 121920
gcaagactct tggagaaagc tgaggagatt ttttaaatgc tccttcatct aatattgtat 121980
aagtatcagg ggtcatagac agatcttttc tgtaaaaggc cagaaaataa acattttagg 122040
ttttgccagc caagcagtct atatcatagc tactcaactc tgctgttcaa ttttttttac 122100
ggacagcgct tttctatttc caaattaaat agctagattg tttatccttg acacacatta 122160
tttatgctta ctgtagaaag caaatatagt agaaaagtac taaaaaagga agtataattc 122220
ctggaactgc cactactcag agataactca tttaatgttt ttaaaaaata ccgtttagac 122280
agatagcttt atgtgggtat atgtactttg tgtgtgtgtg tctctgtgtg tgtgtgtgtg 122340
tatatataca cccatctata taatcttacg taaattgtta agatagatgt ttttgtagtc 122400
tgctttattt actaatctat ttcatagagc tttatcaatt aacatagaac tatggaattt 122460
tttctttaaa attttttttt tctttttttt gtagagacag agtctttctt tgttgcccag 122520
actgatctgc acgaactcct ggcttcaagc gatcctccca cctaagcctc ccaaaatgct 122580
gggatgacag gcgtgaggca ccacacccag ctacaactgt tagttttagt aattgtttat 122640
actttgctgc agggctggca aactatgccc acaggccact tgttttggca aataaagttt 122700
tattggagca caaccatgca catttgctta caaattgtct atggttgctt tcacactaca 122760
atgacagagt agttgtgata gaaaccattt ggcccacagg tcaaaatatt tatcatctaa 122820
tcatttacag agaaagtttg ccaacccctg ctctattgta tagctatatc aaattgtatt 122880
taactcactc tcattgatag gtcttcacta ttttatatct aactataacc ttgggcatcc 122940
ttagggacac taatcttact acttcttcga gagggtactt agaagtggaa ttgttgggca 123000
aaacaggtac acattttaaa ttgagaaata ttgtcagctt accattaaac aatagtttgt 123060
atcaatttgg actctcacaa aaagaagtat gtataagttc cttttagcca tgtacagcag 123120
ctcatgccta taatcctaat gctttgggag gctggggcag gaggatcgct tgaggccagg 123180
agtttgagac cagcttgggc accatagtga aaccccatct ctacaaaaaa tacaaaatta 123240
gcttggcatg gtggtgtgca cctgtagtca caactagttg ggaggctgag gcgagaggat 123300
cacttgagac aggaggtcag atctgtagtg agccatgatt gcgccactgc attccggcct 123360
gggtgacaga gcaagacctt gtctccaaaa aaaaaaaaaa aaaaaaaatc cttttccctc 123420
atgtcatcta ttttaacctt gcaagtctaa caggtgggaa atatttttat tttcagttat 123480
tttactattg agatgggatg tcttcattcg attgttggtc atttgtatct tttgtgagtt 123540
acttgtgtgg gccatctacc cattttctgt ccagtgttag atttctttat caagagtttt 123600
gtttctgata tcttgtgaca taaagaagct taaaattttc atatattttc cctttctgct 123660
tagaagggcc ttccttactc gcattaaaat gcttctatag gctgggtgca gtggctcaca 123720
cctgtaatcc cagcactttg ggaggccaag atgggcagat cacctgattt caggagttca 123780
agaccagcct ggccaacatg atgaaacccc gtctctactc cagatacaaa aattagttgg 123840
gcttggtggc aggtgcctgt aatccttcct acttgggaag ccgagaggcg ggagaattac 123900
ttgaaccctg gaggcagagg ttgcagttag ctgagatcgc gctactgcac tccagcctgg 123960
gtgacagagt gagactctat ctcaaaaaac aaaaaggctt ttataaaatg agtcctcatt 124020
atgttgctaa ttgaatgtgt aatgatttta aaaaccacgt gtggtttaac cagaactttt 124080
tttttttttt tttgagacag agttttcact tttgttgccc acgctggagt gcagtggcgt 124140
gatctcggct cactgcaacc tctgcctcca gggttcaagt aattctcctg cctctcagct 124200
tcctgactag cagggattac aggcacctgc caccatgccc aactaatttt tttttttttt 124260
ttttttgtat tttcggtaga gacagggttt aaccgtgttg gccaggctgg tctcaaactc 124320
ctgacctcag gtgatccacc tgcctcggcc tcccaaagtg ctgggattac aggtgtgagc 124380
caccacacct ggccagaact ttgtttttta acaccaaaac aaattttaaa tattctatca 124440
atcttccaaa aataaaaaaa gtttgggccg gacatggtgg cttacgcctg tagtcccagc 124500
actttgggag gctgaggtgg gcggatcatg aggtcaggag tttgaaacca gcctgaccaa 124560
catggtgaaa cctcacctat actaaaaata caaaaattag ctgggcgtgg tgacacgcac 124620
ctgtaatccc agctactcag gaggctgagg caggagaatc acttgaaccc aggaggcaga 124680
ggttgcagtg agctgagatc acgccattgc actccagcct gggtcacaga gcgagactcc 124740
atatcagaat aaaaaaaaaa aaaagtttgt atttcttatt tatatgtgta cctttcccat 124800
cttttctagg ttttctttat ctggtagcta agaacagaca tgtatatatt tgttcagttt 124860
ctataataac atccttagct gcttgtggtt cttttattat ggtagaaatc ttgagccttt 124920
taaaataaat gagttccata ggtcagaggt aagcctattt ttacaatagt ctatatatat 124980
gtatatacac tgatttatat caagtgtctt taatgttgtt atgttgttga ctgaagattg 125040
atgtggtggt aaagcagaag actgtagtga caagactgac ctgccagatt tgttagatcc 125100
tttgaggctt ttgacatttt aagtcactgt cctcataaca ttctctgtta cagctggctt 125160
cagactcctg aacgtgaata tccttacttc cactttttat cctacagatc ttttttaaaa 125220
aagaaaaatc tttgcttgct tattttcaaa atgactgtaa acatttaaag ggttaacatg 125280
gccgaaacct tctttttgca gtcggtcggg aatattttta gcagagggta caagtttttg 125340
tttttttttt tgtttgtttt ttaagacaga gtttcactct tgttgcccag gctggagtgc 125400
aatggcacga tcttggctca ctgcaacctc cgcctcccag gttgaagtta ttctactgac 125460
tcagcctcct gagtagctgg gattacaggc gcccgccacc acgactggca aattttttgt 125520
atttatagta gagatggggt ttcaccgtgt tggccaggct ggtctcgaac tcctgacctc 125580
aggtgatcca cctgcctcag cctcccaaag tgctgggagt acaggcatga gccaccatgc 125640
ctggccaggg gtacaagttt ttaacctgta cgtatttttc ttgtcagtca ttaaaccaga 125700
ggggcagaac tattaaaaag aaaactccta aagcaaggga taattttctc acgtggtcaa 125760
ggactgtgag aggtgttaca tgatttattt tgctccattt atatgctagg tacagtcact 125820
gtttacctct tcatctacag aggggtgaca taggcaggga cctatttcct gtacatttta 125880
ggctttgccc agtcttattt gcatgacatt aagagtcagg tgagagacag acaggatgtt 125940
tgggtttact gctctctttg acacccagtc agtgttgcca catcattgcc cacagaaata 126000
cagtcattga agaggggcat atctctgtgc tagaatcatt gctgttagga agatagaaaa 126060
agtttgtctt taactcatgg agctgactta ttctatgtct tattgtatgt tgtattttat 126120
gtatgtatga gcagtgatgt ttatgtcagg attctctgtt tcctagccct gacagcatgg 126180
ctgtttttgt ctctttctag gcagactcag tgggatcctc ctacttggga aagcccagga 126240
gatgatgcca gccttgagca tgaagctgag atggacctgg gaactccaac atatgatgaa 126300
aaccccatga aggtgagtgt ggcttacaca tgtatttcct gatcatttgg gagtccgtcc 126360
aagaccatcc cgcatggtct tgggattctt ttttctttat tctgaaaaat aagtgagtga 126420
ctatgcatgt atcaaggtgt agagatgaag tcagggagaa agaatggcct ttttacatat 126480
acaccatgga atactatgca gccataaaaa atgatgagtt catgtccttt gtagggacat 126540
ggatgaaact ggaaatcatc attctcagca aactatcgca aggacaaaaa accaaacacc 126600
gcacgttctc actcataggt gggaattgaa caacgagaac acatggacac aggaagggga 126660
acatcacact ctggggactg ttgtggggtg ggggggaggg gggagggata gcattaggag 126720
atatacctaa tgctaaatga cgagttaatg ggtgcagtac accaacatgg cacatgtata 126780
catatgtaac aaacctgcac gttgtgcaca tctaccctaa aacttaaagt ataataataa 126840
taaaataaaa aaatataaaa aataatccca ttacaaccct gaatcccttt tcaaaaaaaa 126900
aaaaaaaaaa aaaaaaaaga atggcctttt ttagacattg agagactcag atgcatacta 126960
actacttact catttgaggg agatatatgg ccaagaattg tgatgggtgt tcaaaacacc 127020
cattactatg atcgcttcag ggcctctctt gttctctttg cctttttttt ttaaatgaga 127080
cggagtctca ctctgttgcc cgggctggag tgcagtggta caatctcggc tcactgtaac 127140
ctctgcctcc tgggttcaag caattctcct gccttagcct cccgagtagc tgggactaca 127200
gatgtgcact ccacgcccgg ctaatttttg tatttgtagt agagacaggg tttcaccatg 127260
ttggccaggc tggttttgaa ctcctgacca caggtgatct gcctgccttg gcctcctgaa 127320
gtgctgggat tatagatgtg agccaccacg cccggcctct ctttgcattc tgttgttagt 127380
gcccataaca tatgctttcg tgattggtct gttcaaaacc aataggaggg gtgggttttg 127440
ttgttgtgtt ttttgttttt tttggtgtga tcttggctca ctgcaacctc tgcctcctgg 127500
gcttcagcag ttctcatgtc tcaaccaccc aagtagctgg gattataggt gtgcgccacc 127560
atgcctggct aatgtttgta tttttagtag agatgaggtt ttatcgtgtt gcccaggctg 127620
gccttgaact cctgacctca agcaatctgg ctgcttcagc ctcccaaagt gttgggatta 127680
caggcatgag ccaccacagc tgaccgtatg aagtgtcttg aatgaaatca gatatcatat 127740
ttttatgttc taaaacctga ctaatatttt tttaattttg aaaagaatta agtacttcag 127800
tggttaaatt attgggaata ggtggaagaa ggaagaggga agaaaaggag ctggagtgag 127860
aagggattaa agtagaaatg aattcattct tgtttatatt ttattcactt ttggaggaaa 127920
tattttcctc ttttcacatg tgtttggcat ttgcaaaaag atacacactt acgttcaatc 127980
catgtggagt ttgctaaatt tcaaatgaat cacataaatc acttagccac ttcactccag 128040
ctgttgtgct gtcttgtttt cctgaatcat ttaggaatat gcccaagact gctaggcact 128100
tgacatttaa attatatgta agcttaaata caaacaaaaa tcacaactcc catttccaga 128160
cttctgtact gtgttagtta tatcttttga aaaataaaca aagggattaa gataagatct 128220
ggtgcagcaa tacagctgag ttctggggcc aagtttataa agcatgttgg aggccttacc 128280
cttcttaaaa gcccaagttc atgggcaccg taactattaa tcttgattca gtcttttggt 128340
ctagtatatg catattaaat taggcctttc aaagcgaatg aggaatgggc atgaagttca 128400
ctgttgctta tttaatgctc aaggaattgc ctttcttata tgaagacctg tgttaggaaa 128460
tccaggtcat caaactagcc aagcacaaag taggagctga gaagtagggg ccaagtaaaa 128520
gggcagctta tgtgccatgc tacacaatta gacgttcatt ctctggctag ctggtgagaa 128580
agggaaacct ttaaagtgat ttgatcagta acatttgcct tttacaaggc tctctgctgg 128640
agatggactg gaggggttga ccatggagct ggcgccttca caatgagctt attgtagtag 128700
ttaggtctgc tcagcaccca agagcaccag gcaccacctg ttaaaaatgc agagtctcac 128760
tccctgtccc agacctgcta gatcagaatc tgaagtgata caaggtccca aggtaattac 128820
acattcaagt ctaaataatt ggcagtattg tctgtgatca actgtaagag aagtatgatc 128880
ataaaacctt actatatcca accacccaga gtgagtatat ttgtcaggtt atgtttgatc 128940
tttactcctc tgttaccata ggtgcatgtg tgcctgggga gtaggctctt gaaagtatta 129000
tatccaaaag gcaatgcctg aattataatc tactagcttg gaactttgga tctctaaata 129060
cacattttaa atacacacag atctgaactt catctcactc tttcacattt tggttattta 129120
tcagacattt gagttcctat tcagcacaaa tgccatgccc agacctgggg gtacaaaaac 129180
agtataaggc aaggctattg ctcccagggg tcataggaag gtaaggtttg aaaatgtacg 129240
gtattatatg ttaagtggta aactgaggga tttatttatt ttgtcatttg atttgctttg 129300
ctttgttttt agaggcaggg tctccctcac tctgtagccc aggctggagt acagtggtgc 129360
aagcatagct taccgtaacc tcgaactctc aggctcaagt aatcctttcg tctcagcctc 129420
ctgagtggct aggactatag gtacatgcca ccatgcctgg ctaattgtta aaaattgttg 129480
tagagacaac aaacaaggac tttagaggcc tgcaaaagaa aatatagtct atcctaggaa 129540
ggaaaagagc actaaactaa atctaacact taattcacaa ttaattctga tatattgata 129600
tgctcatgtg tgttggggga ggtacatgta taaaaacgaa agggaacggg agattataaa 129660
gagaaaacat tcctcctaat actagctctt aactgcctcg gggggttata gagtagtagt 129720
tccaatggag attcaaaggt atcagcttca ctcagttgtt agagaagatt ggagaggcac 129780
ttttattctt ttctgccatt gtatgtatac ataaataaat ccgcaaataa taatgagagt 129840
gcagaaagaa ttaagctgcc aaatgtattt cctgttgtga acaaataaag gtagaggtct 129900
tctctcccaa aaagaataat cataggctag gcacggcagc ctactttggg aggctgaggt 129960
ggcccgatca cttgaggcca ggagttcaag actagcctag ccaacatggt gaaaccctgt 130020
ggctcaagcc tgtaatccta gcactttggg aggcccaggc aggtggatca cctgaggtca 130080
ggagtttgag accagcctgg ccaacatggt gaaacactgt ctctactaaa aatagaaaaa 130140
ttagctgggc atggtggcac atgcctgagc acatggtaat cccagctgct tgaaaggctg 130200
aggcaagaga atcgcttgaa cccgggagac gggggttgca gtgagccaag attgcaccac 130260
tgcactccaa cctggacaac aagagcgaga ctctgtctca aaaaaaaaaa aaaaaaaaaa 130320
aaaaatcaaa ccatgacagg gcttataact ttagttactt gagtgcaagt gttaagattt 130380
ggtcttggtt ttcagtcaga aattcacata tacaatcaat cagattaact tctctatact 130440
caagagctga gtccccctca gttcttagga gatacacaca ttcccctagg cttcaagcca 130500
gcctccttct agattacttc tccttcaagc ctgtccctgc ctacactggc agtcctgcac 130560
catgtgcttc ctcagcatgg tacaaatggt tgcttatagc tctgttatgc tttttcatcc 130620
tgggagcata gaagaaactc aaccagagaa agttaggagg actttgtgag aaagtggcat 130680
ttgagcttta aaggatgagg aatttttcag taagcaaaga taggctaaaa ggaaagctgg 130740
agcaaaggca gggaaggaag ggagtgttcg ggatatgttt ggggaatagc tctgtttact 130800
tgtatgggaa cataggcatc ataaaacttg taatccagca tgaggttgga agggcattgt 130860
tggggataga tcttggggat ttgaaaatgt aaaagaatat gaacctttgt atggtgggaa 130920
acctttgaat ttttttttag taaaatttat ctcaaggctt atgtttatag gccctaaaat 130980
tcagaaatga tactgtaaat aaaggaattg acaagtactt gtggaaagca attcagtctt 131040
taaggatggc tttttttttt tcatctctga gacagtctag ttctgttgcc caggctgggg 131100
tgcagtggtg cgatctcggc tcattgcaac ttctgcctcc cgggttcaaa cgattctcat 131160
gcctcagcct actgagtagc tgggattaca ggcacctgcc accacgcctg gctgattttt 131220
gtatttggag tagagacagg gtttcaccat gttggccagg ctggtctcga actcctgacc 131280
tcaggtgatc cacttgtctc ggcctcctaa agtgccggga ttataggtgt gagccaccgt 131340
gcccagcttt attatttgtt tttaaatttt tatttgtctt tgctttcttt tggattgatt 131400
tagaatttat ttcaagtatt ctggtttttt tttgtttttg tttttcctat tggcttagcc 131460
atacctcttt attttctttt attttttatt tttttgagcc atggttcact ctgtttccca 131520
ggctggagtg cagtggcacc atcagggttc actgtagtct ccacctacca ggctcagatg 131580
atcctcccgt cttagccacc caagtagcta agttttgtac atttttgtag agacagggtc 131640
tggtggtgtt ggtgaccagg ctggtctcaa acttctggtg tcaagcaatt ttcctgttgt 131700
ggcctcccaa agtgctggga ttataggtgt gagccaccac acctggcctg ctttacttct 131760
tggtggtggt tttaagacag tggttctcaa agtttggtgt ggggacctct aggttcctaa 131820
gactctttca agggagccac aaggtcaaag ctgttttaat aataatatga aaacattaca 131880
tgcctctgtc acatttggta cattcacaaa tataccatgg aattttccag ggggcacatg 131940
acatatttga atgcagaagg caatgagact tcagctgtat tctaagcgag atgtttaaag 132000
agatttccaa aatgtaaaac tgccactctt aactgaattg ctttagtttt ggaaaacagt 132060
tacttttcac aaaaaattat attattgtta tatgtattgt tatataatag atttgctaat 132120
gttattttaa aataatgctt tattttttct cagtttaact taatttctaa tatgaaaaat 132180
tttgatagct ataacccata cgaataaaag ctctttgcgg tcctcagtgt tttaagaata 132240
taaagggata tttatactct ttgtacctac acatttgaaa aaacagtgtt gtaaggttta 132300
cagtatgcat atttatctta tcacaatcta ccattaagtc ctatatttac ccacatattt 132360
accatttcca gcactcttca ttctctcatg tagatttgaa tttccatctg gaatcatttt 132420
cctttagcct aaagaatttc ctttaacatt tctagtattt cagatctact gttgatgcat 132480
tttgtcagct tttgtttgtc tgaagaaagg tatttatctt accacttttt aaaaagtagt 132540
ctttattttt aaagcaattt tagttctgtt ttggcatagc aaaattgaac aggaagtacg 132600
gagagtttcc atataccccc tgtcactaca cacgcacaag cttccctttc tgtcaacatc 132660
aaagcacaag agtggtactt tgttacaatt gatgaatcta ctatgacaca ttattaccac 132720
ccaaagtcca taatttacat tagggttcat tcttggtatt gtacatttgt gggttttaac 132780
aaaggtatcg tgtcatctat atagcatcat agtaacgtac agaatagttt cactgcccta 132840
aaaatcattt gagctgctgc ttactcatca tgccttctct cctcatccct cttccccagt 132900
tcctggtaac cactgatctt tttacagtct tcatagtttt gctttttcca gaatgtcata 132960
tagttagcta cagtaggtag ccttttcaga tcggcttcat tcacttagca atatgcattg 133020
aggcttccac catgtctttt catggcctga tagctcattt cgttttagca ctgaatgtct 133080
gagtgcgccg cagtttgttt atcattcact tactgaagga catcttggtt gcttccaact 133140
tttggcaatt ataaataaag ctactaaaaa catccatgta caggtttatt atgacagata 133200
ctctcactgg atatggaatt ctaaatttat attttcttcc tttcaacact taaaagatgt 133260
ttccattttt taataatagt ttctaataaa aatataatta tctttttccc ccatatgtct 133320
tgattttgcc ttttataaac agtttttagc ggtttgtggt ataccttggt tttgttttct 133380
ttgtgtttaa tctgcttgtg attcttgtac attttagatc catgattggt agttttcatc 133440
aaatatggaa attttttcaa atatatcttt ttataccatt gtcccttttc ctgggactcc 133500
aattacatac atgttattaa accgcttgat actgtctcac agagcaccac atctctgtca 133560
aatttttttc agctcttttc tccctgtgct tcagtttgcg tggtttctgt tggcctctat 133620
ttaaagttca ctgatttacc ttctgctgta ttgaattagc taagctcatc cattgattca 133680
ttttaaaatt tcagttatat ttttctgctc tcaaatttta atttgcatat tttttaatag 133740
ttttaatttc ttttttattt ttaacagtgc tgataaatac ctttcacttc attgtatttt 133800
tcatatttta ttttatttta ttttttttca agacagggtc tcactctgtt gcccaggctg 133860
gagttcggtg gtgcgatctc ggctcactgc aacctccgct tcccaggttt aagtgattct 133920
cctgccttag cctcccaagt agctgggatt acaggtgcct gctaccacgc ccagctaatt 133980
tttgtatttt tatggggttt tgccctgttg gccaggctgg tctcaaactc ctgacctcaa 134040
gtgatctgcc catctgggct tcccaaagtg ctgggattac aggtgtgagt cgtcgtgccc 134100
agccattttt acttcattta aatgtccgct ttttgtagtc aagtcccaga ataaaatgct 134160
atttttagga atatgtttaa ctgaaaaact gcatttaagt gttggcagtt aagcaaacta 134220
actttgcatg ataaagcccc tatcaagtat ctcatactta agcaaatacc cccaaatcat 134280
agtttgtagc tttattgtag cttttttcaa aatacatttt ataccatgtg ttccccagga 134340
aatccctgat atcttcctgt caggtcaaag aaacaagaaa cacaatagga cagtgattat 134400
atttttaagt attaaggggg ttagagtccc aggtattcta tatgcagacc actatactta 134460
tatttgtgtg ttttttattt tgtttttttt ttttgctttt tatttgtgtg ttttaataag 134520
tttctgatcc ataggcttac atttttatag aagctacagt ttgagttcca tgaccagata 134580
aagacagggc agccctgtga tctacaagat tgaagggtgg cttgacgcag tggctcacac 134640
ctgtataatc ctagcacttt gggatgccaa agcaggtgga tccctcaagc ccaggagttt 134700
gagaccagac tgagcaacat ggcaaaacca ttaaaaaatg caaaaaaaaa aattaggcat 134760
gttggtgcac atgtgtagtc ccagctactt ggagggctta ggtgggagga tcacctaagc 134820
cccagaggtc gaggctgcag tgagccaaga tcatgccact gcactccagc ctggtgacag 134880
agtgagacct cgtctcaaaa aaaaaaaaaa aattaaaagt ttgggggtgt ttgatagttc 134940
agggttagga ccatttgttg gtgacattga gatggtcgag ctagtctaca acaaatctat 135000
gtgaggggaa cttggaagtg ttggctgtct tcatggcctc aaaggcctct gccctgtgca 135060
ctacagtgta gcctactcct gccctgtggt caggtagggc atgctcagcc agtagtggtt 135120
ctccagatga ccaatctact gccaccagga atgctactgt ggttggggag gacagtcagg 135180
aacatgatgc cacctgtgct tctcaggagt ctgtcccttt ggcccagtag ttttaatttc 135240
ttcactgtgt tcatgttttc tttcataact gtgagcattt ataatagctt tttaatagtt 135300
gcctgctatt ttcagttgaa cactggacat tgtgaccatt acattgttga gtttcagaat 135360
tttgttactt tccattaaga atgttgagct ttgttctgat agccagtcaa gttacttgtg 135420
gatcaccttg attttttaga ggctgttctt aatctttgtc gggttgagtc cagagtaatt 135480
ttttctctag ggtatctcct aaggcatcac ctgtctggga tctccactga atgccacagg 135540
ttatctaatg gatatctctt cactttagct gatggaagct cacatgtttc ccagcctttt 135600
gtgagctctg agaattgtta gcttatagtt tatctcagat actctaaatt ccaatccttg 135660
tctccttagc tcactgagaa ctccatgctg tgcgtgggtt ttcctctctg ccccagagtc 135720
tggtaaattt ctccacgcag aaaagccaag gtaatcatag ggcttacctc attttgtccc 135780
ttgtctcagg atcatagttt agtgctgctt aatgtccagt gtgtgcaaac tgcctttttc 135840
atgtattttg tctagttttc cagtttttaa ctctgagagg gctaattcat ttaacagtta 135900
atctgtcatg accagaagca caagtctgga caagcttttt aaaaacaaaa caaaacaaaa 135960
aaaccagcat cctggctaac acagtgaaac cccaattcta ctaaaaaaaa tacaaaaaat 136020
tagtcaggtg tgcggggggg cgcctgtagt cctagctact cgggaggctg aggcaggaga 136080
atggcgtgaa cccgggaggc ggaggttgca gtgagccgag atcgcgccac tgcactccag 136140
cctgggcaac agcgagactc catctcaaaa aaaaaaacaa aaacaaaaaa aaaaaccagc 136200
agcagcagca actttattga ggtataataa acctagtata aaatctagtc gctttagatt 136260
tacaatttaa tagcttttag taatttacca aattatgcag ccattaccat aatctggttt 136320
tagaacattt tcctcctccc aataagacct ctcataccca tttgcagtga cttcctagcc 136380
caggcactaa tccatttttt tttaaatttt attattatta tactttaagt tttagggtac 136440
atgtgcacaa tgtgcaggtt tgttacatat gtatacacgt gccatgttgg tgtgctgcac 136500
ccattaactt gtcatttagc attaggtata tctcctaatg ctatccctcc cacttcaacc 136560
caccccacaa cagtccctgg tgtgtgatgt tccccttcct gtgtccatgt gttctctttt 136620
tttttttttt tttttttttt tgagatggag tctcgctctg tcgcccaggc tggagtgcag 136680
tggtgcgatc tcagcttact gcaagctccg cctctcgggt catgccattc tcctgcctca 136740
gcctcctgag tagctgggac tacaggcgcc cgccaccacg catggctaat tttttaaata 136800
ttttttagta gagatggggt ttcaccgtgt tagccagaat gatctcgatc tcctgacctt 136860
gtgatctgcc cacctcagct tcccaaagtg ctgggattac aggcatgagc caatccattt 136920
tctttcttga tagatctgcc tcttgtgggc attttatgta aatgaaataa tacaatatat 136980
ggccttttgt gattggctta ttttatttat ttattttata tatatatact ttaagttctg 137040
gggtacatgt gcagaacgtg cagttttgtt atataggtat acacgtgcca tggtggtttg 137100
ctgcacccat caacccatca cctacatgag gtttttctca taatgccatc cctcccctag 137160
tcccctaccc cctgacaggc cccagtgtgt gatgttcccc ttcctgtatc catgtgttct 137220
cattgttcaa ctcccactta tgagtaagaa cgtgtggtgt ttggttttgt gttctcttgt 137280
gttattttgc tgagaatgat ggtctccagc tttatccatg tccctgcaaa agacatgaac 137340
tcatcctttt ttatggctgc atagtgttcc atggtgtata tatgccacct tttctttatc 137400
cagtctatag ttgatggaca tttgggttgg ttccaagtct ttgctatttt gaagagtgct 137460
gcaataaaaa tatgtgtgca tgtgtcttta cagtagaatg atttataatc cttgtggtat 137520
atacccagta atgggattgc tgggtcaaat ggtatttctg gttctagatc cttgaggaat 137580
tgccgcactg tcttccacaa tggttgaact aatttacact cccaccaaca atgtaaaagc 137640
attcctattt tccacaacct ctccggtgtc tgttgtttcc caacttttta gtgattgcca 137700
ttctaactgg cgtgagatgg tatctcattg tggtttttat ttgcatttct ctaatgacca 137760
gtgatgatga tcattttttc atatgtttgt tggctgcata aatatctttt tttgagaagt 137820
gtctgttcat atccatgccc acgttttgat ggagttgttt gtttttttct tgtaaatttg 137880
tttaagttct ttgtagattc tggatattag ccctttgtca gatggaaaga ttgcaaaaat 137940
tttctcccat tctgtaggtt gcctgttcac tctgatagta gtttcttttg ctgtgcagaa 138000
gctctttagt ttaattagat cccatttgtc aattttggct tttgttgcca ttgcttttgg 138060
tgttttagac atgaagtctt tgcccatgcc tatgtcctga atggtattgc ctaggttttc 138120
ttctaggctt tttatggttt taggtcttat gtttaagttt ataaagcaag aatacagtgg 138180
ggtaattgct atagtagaag aaagtatgaa atgctttggg aacagagaga tacatggttt 138240
gagatgtata ggagtacagt ttcacctata ggtaaccagg actgagtatg ctaggtagat 138300
aaggtgattt tttgcaaagg cttaagaaag aacaagccag tatatatagg agactgaaaa 138360
ataatttggt ttggtgagag tttggatgca tatagggaag ttagcaagac aaagatatgg 138420
aaaagtaggt tagatttaaa ttgtctgaag tcttagtgct ttgctagtat ggttaatgta 138480
atgttgtata ataggtactt gggagtcaat aaatggtttt aatgcaaggg agtcagacag 138540
tcaaatgtgt gtccttctag tgaaatgggc tcattaataa aggtgagatc agtaatagtg 138600
aaatcaaatt ggagagtgtt aatagttagg caaagttagg aactacgact ggagatgctg 138660
gggaatcttg ccaagactga aaagcaggat tgagggttta gcaaacaagt gagtaaggga 138720
gtcatggatg gcctgcaccc tcattcttag cttgggtgga taagatccca tcattcagcc 138780
tagggaatga aagaaagagg aggaggaggt gtggagatta agttcattgt ggagtttgag 138840
ctccctgcag tggctgctag gcaggcaaat ctgggtttga gtcatcagta aattggtgct 138900
tgttggagac agagctgtat ggagtgacat agggaaggca tataatggtc agataattct 138960
ttgaagagtg ctgtctggta gtaaaagctt ttgatgatga gactaaacat tgtgagactg 139020
ttccttttct cttttccatc cattgttgtt cccttcattg tcttgtactc accatcaaga 139080
taagtgtaag tggtggtaag tgtaaagtgt aaagtcaggt cttccctttg agcacctctg 139140
acctgaatta ttactacttg cacaattgag gcagcagttt atttactgct gcctcctggc 139200
ttttaattaa cagtcataag gtataataga tctcctctaa ctatgttatg ttaaaatagt 139260
agttttagag tatttgttgc attgagggag ttgcagagag gtggcatcaa gagccaatgt 139320
atttttcaaa cggggtcttg ctctgtcgcc caggctggag tgcagtggtg tgatctggtc 139380
tcactgcaac ctttgcctcc caggttcaag tggttcttgt gcctcagcct ccgaattagc 139440
tgggattaca ggcatgcacc accaggccca gctaatttgt ttgtttgttt gtttatttgt 139500
ttatttgaga cggagtctca ctctgtcgcc caggctggag tgcaatggtg tgatcttggc 139560
tcactgcacc ctctgcctcc caggttatag caattctcct gcctcagcct cccaagtagc 139620
tgggattaca ggcgcctgcc accacgcctg gctaattttt cgtattttta gtagagacag 139680
tgtttcacct cgttagccag gctggtctcg atctcctgac ctcgtgatcc acccgcctca 139740
gcctcccaaa gtgctgggat tacaggcgtg agtcaccacg cctggccttt ttgtattttt 139800
aatagagatg gggttttgct tttttggcca ggctgatctc aaactcctgg cctcaagtga 139860
tctgctcgcc tcggcctccc aaagtgctgg gattataggc ctgagccacc acatccaggc 139920
tatataaaat ttgtttaaga aataaataat gttgaaaatt tcccatcttg agagagggaa 139980
ataggcatac ggattcatga agcctaaagg atcccaagta aaatcaacca aaagaagaat 140040
accttgagac acattacagt tgtcactctg tatccatagg ggattgattt caagacaccc 140100
tatcatggat gccaaagtct aaagatgctc aagtccctta tatacaaggg cgtagtgttt 140160
gtatgtcacc tacgcacata ctcccatatg ctgtaaatca cctctgtgtt gcgtataata 140220
cccaatacaa tgtaaatgct atataaatag tggttatact gcattggggt tttttaaaat 140280
tggttcttat ttgtattatt tttattgtat tttttttcaa tattttctat ccatggctgg 140340
cctacagatg cagaacacca gctgtactaa gtttttatta ttttcaatga tcttaacctt 140400
ttaaaaattg acatgtacag gttcatgtgc tgcagagctt aggttgaatt gtgtggatag 140460
tgtttatgat ggctcagctt ctcctcctgc ttctggattc atgctgccac aaaagatgta 140520
gttcctcact gaatgattta cattttatgt tctaaacagt attttttttt tcttttttga 140580
gacagagtct cgctctgtca cccaggctgc agtgcagtgg cacgatctca gctcactgca 140640
gactccacct cccgggttca agcagttctc ctgcctcagc ctcccgagta gctgggatta 140700
caggtgcacg ccgccgcgcc tgactaattt ttgtattttt tagtagagac ggggtttcac 140760
catcttggcc aggctggtct cgaactcctg acctcatgat ccacccgcct cagcctccca 140820
aagtgctagg attacaggca tgagccaccg tgcccagccc tctaatcagt atttaattaa 140880
atacagggag agagaagtat tagctgggta tgtcctgctc tgcctttgtc aggactcatt 140940
tctgtaactc aagccatacc ctcttggttc caagtcacat gggctttgtg acatagtcat 141000
gtcaatattt ataataaagg gtgattctgt tgtgttacac agcctgtgta tggttaccag 141060
aactgcccaa taagcttaag gccattgcca actaatccag aaggtctcaa gcttcacctt 141120
gggtaatata aaggtactca ggcctgcctt gtcataatca gaacagattt cctaggaatc 141180
caaatgtgcc acaggtgaag gctgacagca gggtcagctt ctaaaggcag taagctctgg 141240
ctttctgcca ggccctttgc ctgctcattt cattgtgtac tcttaactgt ccacggcctc 141300
acatagattt ccaccagaat ctttaattga ctgatactct atataagcca acacagagaa 141360
aaggcaaact gattattgtt tattgctgag gatctggaag cactcgcttt tttatgtatc 141420
agagccccta ccctgttctc tggtggtttc cttaaaagtg ctttttttct ttttggagac 141480
agcatttcac tctgttgccc aggctggagt gcagtagcat gatcacagct cactgcagcc 141540
tcaacctcct aggctcgcgc aactctccaa cctcaacctc ccaagtaact gggaccacag 141600
gcatagccac catgcccagc taatttttca gtttttttat agagatgctg gtctcgaatt 141660
cctgggctca aacaatctcc ccatcttggc ctcccaaagt gctgggatta caggcatgag 141720
tcactgaacc ccacgtgcta aatttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 141780
tgtgacagat tgttgctctg tctcccaggc tggagtgcaa tggcatgatc tcagctcact 141840
gcaacctcca cctctcccgg gttcaaacga ttctcctgcc tcagcctccc aagtagctgg 141900
gactacaggc acaagcgatt ctcctgcctc agcctcccaa gtagctggga ctacaggcac 141960
gcgccaccac gcccagctaa tttttgtatt tttagtagag acgaggtttc accatgttgg 142020
ccaggatggt cttgatctct tgacctcgtg atccgccctc ctccgcctcc caaagtgcta 142080
ggattacagg cgtgagccac cacacccagc cttacctgct aaatttttaa atgggacttt 142140
tttggagtgg ggggtcctaa ggttgttcat gtcaataaca agtgctgtcc tcaactcaga 142200
ctctggttac tttgcctggc attagatttg agtaaatgtt agccagtttc tgaaattatt 142260
tcccatgcca tttgcaaatc acagaccatg aagagagggt ttcatgaatt tcagtactct 142320
caagagtatt ccattttggt tcatgatttc catgatgtaa gtctggggac ccctcatttt 142380
atcatttcct ttctcgatcc caattgctca gcactcagga ggaccaagaa agctcctaga 142440
cagagctcag tggattgtat tctataattg tgtttttaaa ggccaccccc caccaatccc 142500
ccgccaacct catcaagtca gggattaaat tataaatcta ttaaaagtgc tttgggttca 142560
tttagctttg tgagtgcata ccctatccag agtgaaacag gacatttcta tttacatagt 142620
accctcgctg agagcatggc ctcttctata ggacccagat ctttgagata cccagacctg 142680
aaggggcttt ctgtactcat ttctgttgct gctgacttct gagagctaca agagagtagc 142740
tggggatgtg ttgaagtttt cttgacttac tcaaataatt cttgatccct tgctacctaa 142800
ggtcttactg tggagcatac tcataccatc tacaactggg ggaaaaaaaa taacaaaatc 142860
ccaaagcaaa acacttgaaa atagacttaa cttatattat tagcattatt tttgcttagt 142920
tttgttttct taaaaaacaa attggatctt tatattcttt ttactctacc ccctaatctc 142980
cccatacagc tacatgaaga aattggaaaa atagaaaata cgtaaagctt ttatgacaca 143040
gcagagaaag ttgatttgta acagcctaaa gccaagggag tgccaccttt ctctggagct 143100
agtccagctg ctttagaacc agagccttca tactgtttat ggaaatggaa gaagcagaac 143160
caggagatgg gtggggagca ggaaaattat tctaccctgt gcccctaaca aaaaagtgtg 143220
aagtacctat aatatcaact ccagcttcta gatccattat gaagtaactt atatttggag 143280
gggaatgctc ataattatta ttttccgtgg aaaagcacat ttactgggaa ggggcctgat 143340
ggctagtggt gggcaaaggt atggggagat ggcctgcatg acaggtgctc tgaataccaa 143400
agcttccaac tcatcgcctc ctggtgcagt acctagttag agggaacttg gaagcctccc 143460
tctagcagtg ctggaaggga atgttcctgg gtttgtcatt atcttgccag ctggggacat 143520
agagtatctt ctgtgtcatc atctacttat ctgttcactg gctttgatga ccttcatcac 143580
ctccccgtca atatcgtgat acttccttaa tctttctgtt cctaaactga aggtaccaac 143640
ctccaaggag cctctcttgc atactgagac tgtcttctac agtctagcca actccacctt 143700
tggaggaaag gtgatgagta ttcaagagtc ttcagaacag agcatttcgc ctctgtcctg 143760
gaatcctaga gtgtcagagg tgggagagat ggagcttgtt ttgtgccggc cttgcttgat 143820
agttcaggga gctgaaccca gaacagggac atgagtgact ctgaaatgtg tggctatatc 143880
aaagttgtag ctttgactta gggtagagaa ttggaactta acttataaga aggagagcca 143940
aaccatgtaa caggatttga aacataatag ccaagttgac tccaggcctt gtacctgagt 144000
cagggcctct aaacggattc taataccaag aatcaggtat ccctgctagg ggaaagaaag 144060
gagggttctg ggacagtagg gcatcactaa actgacttct catgccagca ccactgtgtt 144120
ttctcctcca tttttaggcc tcgaaaaagc ccaagacagc agaagcagac acctccagtg 144180
aactagcaaa gaaaagcaaa gaagtattca gaaaagaggt aaggtttggt ggatataagc 144240
actaagctcc tcaggcttaa atctgaaccc tttcatttct tgtcctaagt atgtcgaata 144300
tctcctttgc cccaagatag gcaggaacac aaggtgttcc ttgtgtgtat gtcttgctga 144360
agtgcttctt ttagcactga aaactcctca gccatctttt cttggcttga caggagcccc 144420
tctcagacca catttgcttg tttgactgtg ggccttctgt agcatctatg gcaaaagaaa 144480
gctgtctgta gtggtaggct gccttgtctt tgggtattcc tcttgcttct gtgatttgac 144540
ttagttgtta tgtgaatgac acattggtga aagaggtgtg gcctttttca actggttaag 144600
cacttcagta cccattgact cattttgtcc ccacaacagc ccttgaggta ggcaagacag 144660
attgcctttc ctcttattca ggtgaaagaa ctcttaaggt tcagagaagg caagttctag 144720
acaaaagatt tgaactcagg cgttctggct caaagtccag ttctctttct gtaatatctc 144780
atttggtagc tgcctaattc tccagggctt gggagaatgc tgctcctttt tatgctacca 144840
gaagtgtgtc ttaccaacca tcaagacact aaacttgtct gcttcatagc atctaggttc 144900
taaactccaa tcttcattca ctgaaggggc ttgtagtgtt ttggaagaaa cagacctgta 144960
aataagtagc gacagctgtg tgaaaagtat gccatattag ggctgggagc cacaatctgg 145020
gcagtcagga agggcgcttg aatcaggggt aggaattggc cagatggatc agcaggggat 145080
ctaacttata tcaatagaat gtacagaggc aagagagagc atcttccctt ccagggagtt 145140
gtaagtggcc tgatgggcta tagcacaaga tatgggaggg ctgttgaaaa tgaggtggaa 145200
tggtattgtt cttcttcata taggaactat gtgtctgtgg gttatcggga accattgcag 145260
aattttaagc agggggtaat gaaatcccta tctgtgtttg aggggataga ctgaaggaag 145320
agagtttgga ggccaggaaa ccccagaaaa accttgagtt aaaaggctta tgcagggata 145380
aaatttagtt tcttatggtc cctttgtgaa catactggta tttcagctca ttgaaccagc 145440
agctgtttat ttagtgccta ccttgtgata tagccttgtt ctttgaacac ctgaaggctc 145500
actgaatttt agtgatgggt agactttgtt caaagtgctc tctgatgaaa tggctatgac 145560
tggcctcttt attctctttg tcccctatga tcttagcacc acaaatacct ctgaaggtcc 145620
tattcctaga gtgtttggga gcacctgggt aggacagacc atacttagac agcccaggga 145680
ggacatagta agtggtggaa ggaaaaggat tctgcttagg ttttcctttg ctggctgtca 145740
tatcatgctt ccatctgctt cacatgctgt ggtatgacca cttaaagaat ctaagtaccc 145800
ttcaatgaca aaattcctgt ggttcctggg attgctaagc ctcatagaag ctctggaaca 145860
cctgctgtgc tctgccttgc ctccagggcc cagagaaccc agctactgtc tttatgccaa 145920
ggacacaaaa ttcattgact gaaacctggg gctgctgaag gactcagcat tgaagtcatg 145980
ctgttgagtc cctccagcct cctttaaggc ttgcttagtc catccagggg agctctttcc 146040
ctctcaggct gagcccgtat ccttttctca gatcttactg gcttactagt attccactgt 146100
ccaaaccagt taacctgagg gaggaaaagg agaaggattg gctggcttta ctcactacct 146160
tttctagtta tttcctcagt acaactcctt gccctctctg gactgttgag caacgtgttc 146220
tcttttctct gcctgcagat gtcccagttc atcgtccagt gcctgaaccc ttaccggaaa 146280
cctgactgca aagtgggaag aattaccaca actgaagact ttaaacatct ggctcgcaag 146340
gtactcccct tgcttttggt agcccaccag gcaatgttct gggcaaactg tgtaccttct 146400
aagaagccct tttcatcata gaaagtattt ttttttttct tgtcagatgt cagagctggg 146460
gacccaggaa cggggaggga aggtttgggg agggatgcgt accttacatg acagcagtag 146520
ttctctaaga aattttcaga gctcagcttg tcctttctgg tgatcatagc accagcctgc 146580
cccaacatct acccccttat taacttcctg tcttggtgag aagggccctg aagcagcagg 146640
ctggattacc acccctgtcc tccccctcat ataatttctg ctctgattgg tggctgtggt 146700
ctctcttcct gtgccctgga cagctgactc acggtgttat gaataaggag ctgaagtact 146760
gtaagaatcc tgaggacctg gagtgcaatg agaatgtgaa acacaaaacc aaggagtaca 146820
ttaagaagta catgcagaag tttggggctg tttacaaacc caaagaggac actgaattag 146880
agtgactgtt gggccagggt gggaggatgg gtggtcaggt aagacagact ctagggagag 146940
gaaatcctgt gggcctttct gtcccacccc tgtcagcact gtgctactga tgatacatca 147000
ccctggggaa ttcaaccctg cagatgtcaa ctgaaggcca caaaaatgaa ctccatctac 147060
aagtgattac ctagttgtga gctgttggca tgtggttaga agccatcaga ggtgcaaggg 147120
cttagaaaag accctggcca gacctgactc cactcttaaa cctgggtctt ctccttggcg 147180
gtgctgtcag cgcacagacc catgcgcatc cccacccaca accctttacc ctgatgatct 147240
gtattatatt ttaatgtata tgtgaatata ttgaaaataa tttgtttttt cctggttttt 147300
gtttggtttt cgttttgctt ttagcctcta catgctagga tcacaggaag actttgtaag 147360
gacagtttaa gttctcctgc aaggtttaat ttgttatcat gtaaatattc caaagcaggc 147420
tgccttgtgg ttttggccag ccttgtgcta tgttgataag attgatttac tgcttaaaat 147480
cactttactt tatccaattt ttactgaact ttttatgtaa aaaaataaaa tcaattaaag 147540
aacttggcat gtgtgttccc taaaagttaa 147570
<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence
<400> 2
aaggtgggaa gttcctctgt 20
<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence
<400> 3
ggcaattcta atcaatgtcc cagg 24
<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence
<400> 4
aaccaggtgc tcagcttatc c 21
<210> 5
<211> 25
<212> DNA
<213> Artificial Sequence
<400> 5
aacaaacatt aaagtgttca cctgt 25

Claims (10)

1. An isolated nucleotide containing a new mutation site, the sequence of the nucleotide is shown as SEQ ID NO.1, the new mutation site is positioned at 43529 th site, chr3:47120450 is T-A and 79848 th site, and rs769925323 is T-C.
2. Use of the isolated nucleotide containing a new mutation site according to claim 1 as a molecular marker for congenital heart disease or for the preparation of a reagent or kit for assisting in screening or detecting congenital heart disease.
3. The use according to claim 2, wherein the reagent comprises a primer, a probe, a chip or an antibody.
4. The use according to claim 2, wherein the kit contains one or more reagents selected from the group consisting of:
(a) Specific primers for detecting one or both of said novel mutation sites;
(b) A specific probe for detecting one or both of said novel mutation sites;
(c) A chip for detecting one or two of the new variation sites;
(d) And the specific antibody is used for detecting the mutation of one or two amino acids corresponding to the new mutation sites.
5. The use according to claim 3 or 4, wherein the new mutation site is located at position 43529, chr3:47120450 is t→a, and the primer is:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the new mutation site is positioned at 79848 th site, rs769925323 is T-C, and the primer is:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
6. A kit for aiding in the screening or detection of congenital heart disease, said kit comprising: primer pairs designed according to new mutation sites chr3:47120450 and rs769925323 of the sequence shown as SEQ ID No. 1.
7. The kit according to claim 6, wherein,
the new mutation site is positioned at 43529 th site, chr3:47120450 is T-A, and the primer pair is:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the new mutation site is positioned at 79848 th site, rs769925323 is T-C, and the primer pair is:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
8. A method of using the kit of claim 6 or 7 for non-diagnostic purposes, comprising the steps of:
s1, extracting DNA of three family samples;
s2, amplifying by using the primer pair to obtain an amplified product;
s3, detecting whether new mutation sites chr3:47120450 and rs769925323 shown in SEQ ID NO.1 exist in the family child sample by adopting a Sanger sequencing method.
9. The method of claim 8, wherein the total volume of the amplified amplification reaction system is 50. Mu.l, wherein,
Figure FDA0003440300110000021
10. a special primer pair for detecting SNP locus containing new variation locus nucleotide is characterized in that the nucleotide sequence is shown as SEQ ID NO.1,
the new mutation site is positioned at 43529 th site, chr3:47120450 is T-A, and the primer pair is:
forward primer 5'-AAGGTGGGAAGTTCCTCTGT-3' SEQ ID No.2,
reverse primer 5'-GGCAATTCTAATCAATGTCCCAGG-3' SEQ ID No.3;
the new mutation site is positioned at 79848 th site, rs769925323 is T-C, and the primer pair is:
forward primer 5'-AACCAGGTGCTCAGCTTATCC-3' SEQ ID No.4,
reverse primer 5'-AACAAACATTAAAGTGTTCACCTGT-3' SEQ ID No.5.
CN202111631410.2A 2021-12-28 2021-12-28 Congenital heart disease related SETD2 gene new variation site and application thereof Pending CN116356008A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111631410.2A CN116356008A (en) 2021-12-28 2021-12-28 Congenital heart disease related SETD2 gene new variation site and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111631410.2A CN116356008A (en) 2021-12-28 2021-12-28 Congenital heart disease related SETD2 gene new variation site and application thereof

Publications (1)

Publication Number Publication Date
CN116356008A true CN116356008A (en) 2023-06-30

Family

ID=86929263

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111631410.2A Pending CN116356008A (en) 2021-12-28 2021-12-28 Congenital heart disease related SETD2 gene new variation site and application thereof

Country Status (1)

Country Link
CN (1) CN116356008A (en)

Similar Documents

Publication Publication Date Title
CA2886504A1 (en) Wdr12 polymorphisms associated with myocardial infarction, methods of detection and uses thereof
KR102585973B1 (en) Oligonucleotides to regulate tau expression
TW201632629A (en) Methods for cancer diagnosis and prognosis
ES2524643T3 (en) Control genes for the normalization of gene expression analysis data
AU2023202878A1 (en) Methods for targeted insertion of DNA in genes
AU2016381174A1 (en) Methods for reducing Ataxin-2 expression
KR20180049093A (en) New biomarkers and methods of treatment of cancer
KR20130123357A (en) Methods and kits for diagnosing conditions related to hypoxia
US20030235847A1 (en) Association of polymorphisms in the SOST gene region with bone mineral density
KR20090087486A (en) Genetic susceptibility variants of type 2 diabetes mellitus
CN101631876A (en) Genetic susceptibility variants of Type 2 diabetes mellitus
CN108624683B (en) Application of USP48 gene mutation in ACTH-type pituitary adenoma molecular diagnosis
TW202221014A (en) Compounds and methods for reducing app expression
CN117795076A (en) Methods of treating metabolic disorders with inhibitors of mitogen-activated protein kinase 15 (MAP 3K 15)
TWI358456B (en) Method of determining susceptibility of high myopi
CN108770360B (en) Means and methods for staging, typing and treating cancerous diseases
CN116356008A (en) Congenital heart disease related SETD2 gene new variation site and application thereof
US20040138441A1 (en) Novel gene functionally related to dyslexia
KR102647919B1 (en) APP mutant cell and use thereof
CN111278468A (en) Human adipose tissue progenitor cells for lipodystrophy autologous cell therapy
US20030219787A1 (en) Novel human gene functionally related to dyslexia
CN115485394A (en) Solute carrier family 26 member 5 (SLC 26 A5) variants and uses thereof
CN116355923A (en) New mutation site of congenital heart disease related DGKD gene and application thereof
CN115362255A (en) Treatment of ophthalmic disorders with a Sedum kikunmakii 2 (SOS 2) inhibitor
KR20230032737A (en) PSEN1 mutant cell and use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination