CN116350704B - 一种治疗继发性癫痫的中药组合物及其制备方法 - Google Patents

一种治疗继发性癫痫的中药组合物及其制备方法 Download PDF

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CN116350704B
CN116350704B CN202310352733.0A CN202310352733A CN116350704B CN 116350704 B CN116350704 B CN 116350704B CN 202310352733 A CN202310352733 A CN 202310352733A CN 116350704 B CN116350704 B CN 116350704B
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epilepsy
relieving
traditional chinese
liver
chinese medicine
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CN116350704A (zh
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李雪英
李星谕
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Suixi County Traditional Chinese Medicine Hospital
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Suixi County Traditional Chinese Medicine Hospital
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Abstract

本发明公开了一种治疗继发性癫痫的中药组合物及其制备方法,该中药组合物包括以下组分:醋柴胡6~12g、枳实5~10g、白芍6~12g、甘草3~6g、苍术6~12g、神曲10~15g、香附6~12g、山栀子3~9g、姜半夏6~12g、陈皮6~12g、茯苓6~12g、荆芥5~9g、白芥子5~10g、莱菔子6~12g、乌梅6~9g、鸡内金6~12g、焦山楂10~15g、槟榔5~10g、丹参6~15g、全蝎3~6g、蜈蚣1~2条、蝉衣3~6g、僵蚕6~10g、琥珀1~3g。此方具有祛风、化痰止痫、行气活血、疏肝解郁、散结、化积行滞、杀虫、消导、解痉清火、镇惊消除癫痫等作用。

Description

一种治疗继发性癫痫的中药组合物及其制备方法
技术领域
本发明属于中医药技术领域,具体涉及一种治疗继发性癫痫的中药组合物及其制备方法。
背景技术
继发性癫痫发病特殊,病因病机复杂,属于比较棘手的疑难奇症。其病因如风、寒、痰、湿、火、郁、瘀、积、虫、脂浊、糖毒等致病因素太过,皆能损害人的心、肝、胆、脾、肾,多种内外致病因素损害脑神经,继而引起继发性癫痫。该疾病治疗起来相当棘手,难以根除。发病率逐年增多,其临床症状多种多样:如人不慎感受了风寒湿,风痰上蒙清窍则脑神失灵,痰热扰神则神志失灵,寒痰作祟、顽痰出怪症,脑神经也会失灵。肝气不舒郁久化热,热耗津液而成痰,痰火扰心则脑神失灵。气郁化火,肝胆相表里,胆火过旺,肝胆不宁,神不守舍则脑神失灵。饮食失调,如挑食、偏食、多食、食肉类多,导致胃肠积滞,便秘、腹疼、头痛、头晕、呕吐、四肢抽搐、口唇瞤动、吐白沫,发作过后,以如常人。还有年龄偏小的患者,夜间不安、趴着睡、流口水、咬牙、四肢抽动,吃饭时会有腹痛、不欲食、哭闹、烦躁易怒、怒气则症状加剧,有的呕吐黄水、清水、痰涎,迁延日久,反复发作,在发作期间脑电图可发现癫痫电波,可诊断为继发性癫痫。严重影响病人的身心健康和日常生活。
发明内容
基于以上病机认识及通治法则,本发明提供一种治疗继发性癫痫的中药组合物及其制备方法,根据病人多种临床症状和病因,运用中医理论研究分析辨症分型。临床上可暂不分缓急标本,概以调理心、肝、胆、脾、肾为主,针对主要病理要素,直捣病邪巢穴,祛邪方能安正。
本发明是通过以下技术方案实现的:
一种治疗继发性癫痫的中药组合物,包括以下组分:醋柴胡6~12g、枳实5~10g、白芍6~12g、甘草3~6g、苍术6~12g、神曲10~15g、香附6~12g、山栀子3~9g、姜半夏6~12g、陈皮6~12g、茯苓6~12g、荆芥5~9g、白芥子5~10g、莱菔子6~12g、乌梅6~9g、鸡内金6~12g、焦山楂10~15g、槟榔5~10g、丹参6~15g、全蝎3~6g、蜈蚣1~2条、蝉衣3~6g、僵蚕6~10g、琥珀1~3g。
优选地,还包括钩藤10~15g、僵蚕3~10g、地龙5~15g。
优选地,还包括生姜3~5g、竹茹6~10g、川贝母3~9g、石菖蒲6~10g、远志6~10g、胆南星5~10g。
优选地,还包括太子参8~15g、麦冬6~15g、五味子5~10g、酸枣仁7~12g。
优选地,还包括白芷6~9g、川芎6~9g。
优选地,还包括珍珠母20~30g或朱砂1~2g。
优选地,还包括熟地10~15g、当归5~15g、菟丝子10~15g。
优选地,还包括焦麦芽6~15g、元胡6~10g、川楝子6~10g、茵陈6~12g、薄荷6~8g、车前子6~15g、白术6~12g、大黄4~6g。
优选地,将上述中药组合物制成药学上可接受的汤剂。
一种治疗继发性癫痫的中药组合物的制备方法,包括以下步骤:
首先制备醋柴胡,用醋拌柴胡浸透,炒至微黄即可;除琥珀粉、朱砂外,将其余原料药按重量份放进煎药机内,加适量水泡1h后,开启煎药机进行煎熬1h,再去渣过滤,自动包装成袋,规格为100~200mL,即可。
一种治疗继发性癫痫的中药组合物的制备方法,包括以下步骤:
首先制备醋柴胡,用醋拌柴胡浸透,炒至微黄即可;除琥珀粉、朱砂外,将其余原料药放入砂锅内,加水没过原料药2cm,浸泡30min;上炉煎煮,先武火,煮开锅后,然后继续文火煎煮20~30min,滤出药汁,再加水煎,二次滤汁,将两次煎煮所得药汁合并,即可。
本发明各原料药的药物机理分别如下:
醋柴胡:辛、苦、微寒,归心包络,肝、胆、三焦经。功效主治:解表退热疏肝解郁、胸胁苦满、腹痛、头痛头晕、呕吐、治大肠停积、下气消食、治心下痞、胸膈中痛、能疏肠胃之滞气。加工法:用醋拌柴胡透、炒制微黄即可。
枳实:味苦、微寒,归脾、胃、大肠经,功效主治:破气消积,化痰除痞,治食积停滞、腹胀便秘、积滞泻痢。湿痰咳嗽、胸痹、心痛、子宫下垂、胃下垂、脱肛等。
白芍:苦、酸、凉,归肝经、脾经。功效主治:养血柔肝,缓中止痛,敛阴止汗,平肝潜阳。治血虚、胸腹胁肋疼痛、泻痢腹痛、自汗盗汗、肝阳眩晕等。
甘草:甘、平。归心、肺、脾、胃经。功效主治:补脾益气,润肺止咳、缓急止痛、缓和药性。治脾胃虚弱、食少、自汗、脉结代、腹胀便溏、劳倦发热、肺萎咳嗽、心悸。
苍术:辛、苦、温。归脾、胃经。功效主治:燥湿健脾,祛风湿。治湿困脾阳,脘腹胀满、不思饮食、倦怠嗜卧、消化不良、呕吐等。
神曲:甘、辛、温。归脾、胃经。功效主治:消食和胃。治饮食积滞、食不消化、脘腹胀满、嗳气反酸、泻痢,小儿消化不良等。
香附:辛、微苦,平。归肝、三焦经。功效主治:疏肝理气、调经止痛。治肝气郁结,胁肋疼痛,胃脘疼痛、消化不良等。
山栀子:苦、寒。归心、脾、肺、胃、三焦经。功效主治:泻火除烦,清热利湿,凉血解毒。治热病发热、心烦懊恼、黄疸、热淋、消渴、目赤、口疮、吐血、便血等。
姜半夏:辛、温。有毒。归脾、胃、肺经。功效主治:燥湿化痰,降逆止呕,消痞散结。治痰食冷饮、咳喘痰多、呕逆反胃、胸膈胀满等。
陈皮:辛、苦、温。归肺、脾经。功效主治:理气调中,燥湿化痰。治脘腹胀痛,痞闷不食、呕吐呃逆、咳嗽痰多、乳痈等。
茯苓:甘、淡、平。归心、脾、肾、膀胱经。功效主治:利水渗湿,健脾安神。治脾虚水肿、食少便溏、小便不利、痰饮咳嗽、呕哕、泄泻、神疲乏力、心悸失眠、健忘等。
荆芥:辛、微温。归肺、肝经。功效主治:祛风解表,止血。治外感发热、咽喉肿痛、头晕目眩、目赤、口眼歪斜等。
白芥子:辛、温。归肺经。功效主治:温肺祛寒,利气散结,通络止痛。治痰饮咳喘、胸胁胀满疼痛、肢体痹痛麻木、跌打损伤等。
莱菔子:辛、甘、平。归肺、脾、胃经。功效主治:消食化积,降气化痰。治食积气滞、腹胀疼痛、消化不良、气逆痰喘、咳嗽、脘腹胀满等。
乌梅:酸、平。归肝、脾、肺、大肠经。功效主治:敛肺,涩肠,生津,安蛔。治久痢久泻、肺虚久咳、口干烦躁、蛔虫腹痛等。
鸡内金:甘、平。归脾、胃、小肠、膀胱经。功效主治:运脾消食,固精止遗。治饮食积滞、脘腹胀满、反胃吐食。泻痢、疳积、消渴、遗尿等。
焦山楂:甘、酸、温。归脾、胃、肝经。功效主治:消食化积、活血散瘀。治肉食、乳食、面食等积滞、脘腹痞满等。
槟榔:苦、辛、温。归胃、大肠经。功效主治:杀虫、消积、行气、利水。治驱绦虫、姜片虫、蛔虫、血吸虫、脚气浮肿、食积不消、腹痛胀满、腹水、泄泻、痢疾、蛔厥。治疗猪囊虫侵入脑内引起脑神经失常、脑电图发现癫痫电波的囊虫性癫痫病。
丹参:苦,微寒。归心、心包、肝经。功效主治:活血祛瘀,凉血消肿,养血安神。治胸痹心痛、月经不调、症瘕积聚、瘀血腹痛、惊悸失眠等。
全蝎:辛、平。有毒。归肝经。功效主治:熄风止痉,解毒,通络止痛。治惊风抽搐、癫痫、中风、半身不遂、口眼歪斜、风湿痹痛、破伤风等。
蜈蚣:辛、咸,温,有毒。归肝经。功效主治:熄风止痉,解毒散结,通络止痛。治惊痫抽搐、破伤风、口眼歪斜、角弓反张等。
蝉衣:甘、寒。归肺、脾经。功效主治:疏风热,透疹,明目退翳,熄风止痉,止外感风热、头痛、咽喉肿痛、失音、惊风抽搐、破伤风等。
僵蚕:咸、辛、平。归肝、肺经。功效主治:息风止痉、祛风止痛,解毒散结。治急慢惊风、痉挛抽搐、癫痫、头风、喉风、喉痹、失音、乳痈、丹毒等。
琥珀:甘、平。归心、肝、膀胱经。功效主治:定惊安神、活血散瘀、利尿通淋。治惊风癫痫、心悸失眠、闭经、产后腹痛、痈疽疮毒、跌打损伤、血淋、尿血、小便不利等。
钩藤:甘、微寒,归心包经。功效:息风止痉,清热平肝。
地龙:咸、寒,归肝、脾、膀胱经。功效:清热息风,平喘,通络,利尿。
生姜:辛、微温,归肺、脾经。功效:发汗解表,温中止呕,温肺止咳。
竹茹:甘、微寒,归肺、胃、胆经。功效:清热化痰,除烦止呕。
川贝母:苦、甘,微寒,归肺、心经。功效:化痰止咳,清热散结。
石菖蒲:辛、温。归心、胃经。功效:开窍宁神,化痰和胃。
远志:辛、苦,微温,归肺、心经。功效:宁心安神,祛痰开窍,消痈肿。
太子参:甘、微苦,平,归脾、肺经。功效:补气生津。
麦冬:甘、微苦,微寒。归肺、心、胃经。功效:润肺养阴,益胃生津,清心除烦。
五味子:酸、温。归肺、肾、心经。功效:敛肺滋肾,生津敛汗,涩精止泻,宁心安神。
酸枣仁:甘,平。归心、肝经。功效:养血安神,敛汗。
白芷:辛、温。归肺、胃经。功效:解表,祛风燥湿,消肿排脓,止痛。
川芎:辛、温。归肝、胆、心包经。功效:活血行气,祛风止痛。
珍珠母:咸、寒。归肝、心经。功效:平肝潜阳,清肝明目。
当归:甘、辛、温。功效:补血,活血,止痛,润肠。
山萸肉:酸,微温。归肝、肾经。功效:补益肝肾,收敛固涩。
菟丝子:辛、甘、平,归肝、肾经。功效:补阳益阴,固精缩尿,明目止泻。
朱砂:甘、寒。归心经。功效:镇心安神、清热解毒。
焦麦芽:甘、平。归脾、胃、肝经。功效:消食和中。
元胡:辛、苦、温。归心、肝、脾经。功效:活血、行气、止痛。
川楝子:苦、寒,有小毒。归肝、胃、小肠、膀胱经。功效:行气止痛,杀虫,疗癣。
茵陈:苦、微寒。归脾、胃、肝、胆经。功效:清热利湿、退黄。
薄荷:辛、凉。归肝、肺经。功效:疏散风热,清利头目,利咽,透疹。
车前子:甘、寒。归肾、肝、肺经。功效:利尿通淋,止泻,清肝明目,清肺化痰。
白术:苦、甘、温。归脾、胃经。功效:补气健脾,燥湿利水,止汗安胎。
胆南星:苦、辛,温,有毒,归肺、肝、脾经。功效:燥湿化痰,祛风止痉。
明天麻:甘、平。归肝经。功效:息风止痉,平肝潜阳。
大黄:苦、寒。归脾、胃、大肠、肝、心经。功效:泻下攻积,清热泻火,解毒,活血祛瘀。
熟地:甘,微温。归肝、肾经。功效:养血滋阴,补精益髓。
本发明的有益效果如下:
此方具有祛风、化痰止痫、行气活血、疏肝解郁、散结、化积行滞、杀虫、消导、解痉清火、镇惊消除癫痫等作用。此方治愈的患者经多年观察,往往不再复发。本发明原料药来源丰富,成本低廉,制作方法简便易行,使用安全简便,无任何副作用,用于治疗继发性癫痫疗效明显。
具体实施方式
下面结合具体实施例对本发明做进一步详细说明。
实施例1
一种治疗继发性癫痫的中药组合物,方药组成:根据患者的年龄、体质、病情注重量效关系。通治方的具体组分如下:
醋柴胡6~12g(用醋拌柴胡浸透,炒至微黄即可)、枳实5~10g、白芍6~12g、甘草3~6g、苍术6~12g、神曲10~15g、香附6~12g、山栀子3~9g、姜半夏6~12g、陈皮6~12g、茯苓6~12g、荆芥5~9g、白芥子5~10g、莱菔子6~12g、乌梅6~9g、鸡内金6~12g、焦山楂10~15g、槟榔5~10g、丹参6~15g、全蝎3~6g、蜈蚣1~2条、蝉衣3~6g、僵蚕6~10g、琥珀1~3g(分次冲服)。
对于本方的加减法:
(1)如抽搐较甚者,可加钩藤10~15g、僵蚕3~10g、地龙5~15g以止痉。
(2)若痰浊较甚、头目不清、胸闷、呕恶者,可酌加生姜3~5g、竹茹6~10g、川贝母3~9g、石菖蒲6~10g、远志6~10g、胆南星5~10g,以增强降气化痰、开窍之功。
(3)若心神受损、心悸不安、夜寐不宁,可酌加太子参8~15g、麦冬6~15g、五味子5~10g、酸枣仁7~12g,益气养阴安神。
(4)伴有发作后或平时头晕头痛者,可酌加白芷6~9g、川芎6~9g。
(5)若发作前有幻听幻视者,可加珍珠母20~30g(先煎),潜镇安神。
(6)如在急性期癫痫发作频繁,煎服汤剂时,另加朱砂1~2g分次冲服,可增强疗效。
(7)肝肾阴虚证者,可加熟地10~15g、当归5~15g、菟丝子10~15g,养肝益肾。
(8)肝胃不和、脾虚湿阻、食积腹痛、便秘者,可加焦麦芽6~15g、元胡6~10g、川楝子6~10g、茵陈6~12g、薄荷6~8g、车前子6~15g、白术6~12g、大黄4~6g,疏肝和胃、运脾化积、消食导滞、清热化湿、通便。
方剂加工:以上述通治方为基础方,根据患者病情加减药量定方后,再制作汤剂,分为煎药机制备和砂锅煎药两种方式,具体如下:
(1)煎药机制备:除琥珀粉外,将其余原料药按重量份放进煎药机里,加上适量的水泡1h,开始煎熬1h;待煎药机到了提前制定的时间鸣响后,去渣过滤,自动包装成袋,规格为200mL、150mL、100mL,即可。
(2)砂锅煎药:除琥珀粉外,将其余原料药按重量份放入砂锅内,加水超过药二公分,浸泡30min;上炉煎煮,先武火,煮开锅后,再继续文火煎20~30min,滤出药汁,再加水煎,二次滤汁,将两次煎煮所得药汁合并,即可。
实施例2
按照实施例1的方式制备本方汤剂,并结合病机认识及通治法则进行治疗。
治疗原则当尊泻实补虚,泻多于补;调和阴阳,潜多于滋。因此,拟定潜镇息风止痉定痫、消食导滞、消积、化痰理气、活血化瘀通络、开窍醒神、宁心定志、安神定痫之方后,注重治疗原发病因,以巩固疗效,最终达到根除而治愈。治疗经验:根据临床治疗经验总结拟出“通治法与通治方”,临证主张辨病论治和辨证论治相结合,在掌握疾病的中西医病理机制和病证发展变化规律基础上,根据临床治疗“总结经验——重复经验——推广经验”的目标和需求,可拟定“通治法则”,并且遵循通治法则的基本精神,拟定出与之相对的,行之有效的“通治方”。根据多年来对临床诊疗实践的体悟,认为中医“辨病论治”发展过程,就是寻求更切合病证、便于在辨病论治中广泛应用的“通治方”的过程。所谓专病通治方,就是针对某一疾病的若干证型均能通治获效的方剂,前人也有称之为“主方”,此即反映了医者对疾病的认识是逐步深入的。对于癫痫而言,发明人通过长期的临证实践、积累和摸索,认为对该病的中医因证脉治,只要能够抓住主要矛盾,运用通治法则与辨证论治,可以做到并行不悖,甚至是融合互补。
使用方法:成人每次口服200mL,未成年人50—100—150mL,日服二次,早、晚各一次,五日一疗程。需要配服琥珀的,按比例分次冲服。
注意事项:服药期间不怒气,不抽烟,不喝酒,忌吃生凉辛辣、油腻、肉类等食物,避免受惊、恐吓等。
疗效评定标准:治愈:一切病症皆无;显效:略有不适;好转:发作次数减少、程度减轻;无效:病症依旧。
病例总结如下表1所示:
表1病例总结
人数 治愈 显效 好转 无效 有效率
86 65 12 5 4 95.3%
实施例3
临床病例:
陈某某,男,11岁,安徽肖县梧桐人。
初诊:其母代述:患儿五年以来,挑食,啃手指头,偷吃雪糕,喝凉水,夜睡蹬被,开电扇,吃饭时哭闹,体瘦,呕吐痰涎水,有时说头晕头痛。两年前某日夜间突然手足抽搐、双目上视、口唇瞤动、口流白沫、昏不知人,两分钟即发作停止,昏睡五分钟,醒后如常人。后来一日或二、三日发作一次,症状同上。经某医院脑电图检查发现癫痫电波,确诊为癫痫。服用苯巴比妥、苯妥英钠罔效。前来发明人所在中医院门诊就诊。来诊时见:面色萎黄,头发亦黄,体瘦神迷,舌胖淡边齿痕下瘀,脉弦细滑尺弱。
中医诊断:继发性癫痫,寒湿伤及肝脾胃、风痰上蒙清窍型。治宜:祛风温中燥湿、化痰醒脑、解痉定痫。
方药:癫痫通治方加减,荆芥5g、白芥子5g、姜半夏6g、生姜5g、陈皮5g、茯苓6g、苍术6g、神曲8g、鸡内金6g、僵蚕5g、蜈蚣1条、全蝎3g、乌梅4g、炙甘草4g。取10帖,每日1帖,水煎2次,早晚2次分服。
过10天后复诊:上方药后,患儿较前有精神,据家长所述:孩子服此方10天,以上诸症都有所减轻。原方继服,又取10帖。
又过2周后三诊:据家长所述:孩子精神基本上恢复正常,吃饭香甜,不哭不闹,头不晕不痛,不挑食,不啃指头,不再偷吃雪糕,15天癫痫未发作。原方再取20帖,服法同上。
再过1个月后四诊:据家长所述:孩子癫痫30天未发作。上方又取30帖。
之后随访至今未再发作。
实施例4
临床病例:
张某某,女,26岁,住淮北张庄矿。
初诊:主诉:自1995年开始,因受惊恐导致癫痫病,后每遇惊吓,每逢气郁皆易癫痫发作。症状是双目上视、口唇瞤动、发出异常叫声、四肢抽搐、手足抓动,三分钟则停止,止后嗜睡半小时,醒后自觉心跳过快,平素心里有恐惧感,能有个小孩在她跟前,自己才觉得大胆,多则每月27-28号月经快来时或临来时发作。多数都在夜间发作。舌偏红,苔薄黄,脉弦滑数。
诊断:继发性癫痫(惊恐伤肾、怒气伤肝、气机逆乱、冲任失调、心脑失灵使然)。
治宜:养肝益肾、调固冲任、疏肝镇惊、宁心安神、益智定痫。
方药:癫痫通治方加减,醋柴胡12g、枳实10g、熟地15g、当归10g、白芍12g、川芎8g、山萸肉15g、菟丝子15g、石菖蒲12g、远志12g、茯神12g、全蝎4g、蜈蚣2条、琥珀1g冲服、朱砂1g冲服、炙甘草6g。取10帖,水煎二次,早晚分服。
过2周后复诊:上方药后,惊恐已止,月经来时癫痫未再发作。守上方又取10帖,煎服法同上。
又过2周后三诊:上方药后,自己独睡已不再恐惧。守上方取20帖,煎服法同上。
再过3周后四诊:上方药后,不但自己单独或睡觉不恐惧,癫痫也不再发作,为了根除癫痫,上方又取30帖。
之后随访服完药后至今癫痫未再发作。
实施例5
临床病例:
刘某某,男,12岁,濉溪县人。
初诊:其父代述:该患儿从小爱多吃肉、糖食,性急易怒,近日突然发作腹痛,头晕昏不知人,呕吐,大便稀溏,七分钟即止,每天都发作,反复发作不止,夜间磨牙,流口水,胃胀夜卧不安,舌红苔黄腻,脉弦滑。脑电图发现异常电波发放。
病机分析:中医儿科有“要想小儿安,必需三分饥和寒”之言。小儿偏食,多食肉类、糖类,不知饥饱,积食不化,久则伤及脾胃,脾胃积滞则胃胀腹痛、脾壅肝郁,故心烦易怒,呕吐,舌红苔黄腻,脉弦滑,皆是湿热内盛,则脾不升清、胃不降浊,湿热上蒙清窍,故突然头昏不识人,而癫痫发作。
诊断:继发腹痛性癫痫(积滞型)。
治宜:疏肝和胃、运脾化积、消食导滞、清热化湿、醒脑开窍、解痉定痫。
方药:癫痫通治方加减,醋柴胡7g、枳壳8g、赤芍和白芍各10g、连翘10g、焦三仙(焦麦芽、焦山楂、焦神曲)各15g、川芎6g、元胡6g、川楝子6g、茵陈15g、薄荷6g、车前子6g、鸡内金8g、白术10g、姜半夏7g、陈皮6g、石菖蒲6g、全蝎3g、蜈蚣2条、甘草4g。取7帖,每天1帖水煎二次,早晚二次分服。
过3周后复诊:上方药后,每天发作1次,症状减轻,守上方取7帖,煎服法同上。
又过1周后三诊:服药7天只发作1次,症状较前减轻,守上方继服,取10帖,煎服法同上。
再过2周后四诊:服药10天癫痫未发作,守原方取20帖,煎服法同上。
又过1个月后五诊:服药20天癫痫未有发作,原方又取20帖。
再过一年后随访未再发作。
实施例6
临床病例:
曹某某,男,8岁,濉溪县人。
初诊:父母代述:患儿自幼挑食,不断头晕腹痛干呕,心烦易怒,偏肉食,吃零食,大便三日一次,口腔异味,近一年来,不时突然身冷头晕、心跳、胸闷、喘半气、心律加块、出汗、面色苍白、视物成双、斜视,十分钟即止,停后五分钟症状缓和,心律平稳,已如常人。每天发作一次,舌暗淡红,脉弦滑。脑电图:轻度异常电波。彩超:肠系膜淋巴结肿大。
病机分析:患儿自幼偏肉食,吃零食,大便三日一次,日久胃肠积滞(肠系膜淋巴结肿大)、脾胃失和,气机升降失调,心火生脾土(心母脾子)、脾病及心、心脾同病,故表现头晕、干呕、心烦、心跳、胸闷、喘半气、出汗、面色苍白、视力异常等。舌暗红,脉弦滑皆属小儿甘积、肝郁痰阻之像,脑电图、彩超之异常皆属心肝脾同病之征。
诊断:继发特异型癫痫(积滞损及心肝脾使然)。
治宜:化积消食、导滞化痰、疏肝运脾、和胃止呕、醒脑宁心、解痉定痫。
方药:醋柴胡8g、枳壳8g、白芍6g、炒莱菔子10g、焦槟榔10g、胆南星6g、红景天12g、明天麻6g、钩藤3g、姜半夏6g、生姜3g、山楂10g、大黄4g、石菖蒲6g、甘草4g、蜈蚣2条、僵蚕6g。取5帖,每日1帖,水煎2次,早晚分服。
过1周后复诊:上方药后,头不晕,不呕吐,呼吸如常;心律快、出汗、眼视物异常有所减轻。守上方继服,取7帖,煎服法同上。
又过1周后三诊:上方药后,症减拾之七八,守上方取7帖继服巩固之。
再过10天后四诊:上方药服完诸症不再发作,上方取7帖,继续巩固之。
又过10天后五诊:来诊时据父母所述:患儿已痊愈。
再过一年后随访,患儿癫痫未再发作。
应当指出的是,具体实施方式只是本发明比较有代表性的例子,显然本发明的技术方案不限于上述实施例,还可以有很多变形。本领域的普通技术人员,凡在本发明的精神和原则之内,所作的任何修改、替换、改进等,均应包含在本发明的保护范围之内。

Claims (3)

1.一种治疗继发性癫痫的中药组合物,其特征在于,由以下组分制成:醋柴胡6~12 g、枳实5~10 g、白芍6~12 g、甘草3~6 g、苍术6~12 g、神曲10~15 g、香附6~12 g、山栀子3~9g、姜半夏6~12 g、陈皮6~12 g、茯苓6~12 g、荆芥5~9 g、白芥子5~10 g、莱菔子6~12 g、乌梅6~9 g、鸡内金6~12 g、焦山楂10~15 g、槟榔5~10 g、丹参6~15 g、全蝎3~6 g、蜈蚣1~2条、蝉衣3~6 g、僵蚕6~10 g、琥珀1~3 g。
2.权利要求1所述的一种治疗继发性癫痫的中药组合物的制备方法,其特征在于,包括以下步骤:
首先制备醋柴胡,用醋拌柴胡浸透,炒至微黄即可;除琥珀粉外,将其余原料药按重量份放进煎药机内,加适量水㓎泡1 h后,开启煎药机进行煎熬1 h,再去渣过滤,自动包装成袋,规格为100~200 mL,即可。
3.权利要求1所述的一种治疗继发性癫痫的中药组合物的制备方法,其特征在于,包括以下步骤:
首先制备醋柴胡,用醋拌柴胡浸透,炒至微黄即可;除琥珀粉外,将其余原料药放入砂锅内,加水没过原料药2 cm,浸泡30 min;上炉煎煮,先武火,煮开锅后,然后继续文火煎煮20~30 min,滤出药汁,再加水煎,二次滤汁,将两次煎煮所得药汁合并,即可。
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