CN116328070A - Spiral diversion integrated film type oxygenator - Google Patents
Spiral diversion integrated film type oxygenator Download PDFInfo
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- CN116328070A CN116328070A CN202310546603.0A CN202310546603A CN116328070A CN 116328070 A CN116328070 A CN 116328070A CN 202310546603 A CN202310546603 A CN 202310546603A CN 116328070 A CN116328070 A CN 116328070A
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- blood
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- 239000008280 blood Substances 0.000 claims abstract description 128
- 210000004369 blood Anatomy 0.000 claims abstract description 128
- 239000012528 membrane Substances 0.000 claims abstract description 99
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 71
- 239000012510 hollow fiber Substances 0.000 claims abstract description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 22
- 239000001301 oxygen Substances 0.000 claims abstract description 22
- 238000005192 partition Methods 0.000 claims description 120
- 230000000903 blocking effect Effects 0.000 claims description 18
- 238000009792 diffusion process Methods 0.000 claims description 12
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 230000001706 oxygenating effect Effects 0.000 claims 2
- 239000000835 fiber Substances 0.000 abstract description 4
- 230000008859 change Effects 0.000 description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- 125000006850 spacer group Chemical group 0.000 description 10
- 230000017531 blood circulation Effects 0.000 description 9
- 210000004204 blood vessel Anatomy 0.000 description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 239000001569 carbon dioxide Substances 0.000 description 5
- 230000004087 circulation Effects 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W10/00—Technologies for wastewater treatment
- Y02W10/10—Biological treatment of water, waste water, or sewage
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- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
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Abstract
The application relates to a spiral water conservancy diversion integrated form membrane oxygenator, include: a lower cover having an air outlet pipe; an oxygenation part comprising a mandrel structure, an oxygenation shell and an oxygenation silk membrane structure, wherein the oxygenation shell is provided with a blood outlet tube; the upper cover is provided with a blood inlet pipe and an oxygen inlet pipe, and the oxygen inlet pipe and the air outlet pipe are communicated with a space between the mandrel structure and the oxygenation shell; the central spindle structure comprises a central spindle body and an annular flow guide plate, a blood channel is arranged between the first end part and the upper cover, the annular flow guide plate is provided with a plurality of flow guide perforations, and the plurality of flow guide perforations of the annular flow guide plate are distributed on the annular flow guide plate; the oxygenation fiber membrane structure comprises a plurality of hollow fiber layers, each hollow fiber layer is provided with a plurality of hollow fiber pipes, the plurality of hollow fiber pipes incline at an angle relative to the vertical plane, and the inclination direction of the plurality of hollow fiber pipes of each hollow fiber layer is different from the inclination direction of the plurality of hollow fiber pipes of the adjacent hollow fiber layers and mutually intersected. So can promote the utilization ratio and the oxygenation efficiency of silk membrane structure.
Description
The application is a divisional application of a spiral diversion integrated membrane type oxygenator with application date of 2017, 09 and 12, application number of 201710817792.5 and patent name.
Technical Field
The application relates to the technical field of medical instrument products, in particular to a spiral diversion integrated membrane type oxygenator.
Background
The membrane oxygenator is a medical instrument for replacing lungs by cardiac arrest, has the function of regulating the oxygen and carbon dioxide content in blood, is a necessary medical device for cardiovascular surgery, and is also a necessary medical device for treating acute respiratory diseases and waiting for a lung transplantation stage. The membrane oxygenator is based on the principle that venous blood in a body is led out of the body, oxygen and carbon dioxide are exchanged after passing through the membrane oxygenator to become arterial blood, and then arterial system of a patient is returned, so that supply of oxygenated blood of organ tissues of the human body is maintained, lung effect is temporarily replaced in the operation process, and meanwhile, a quiet, bloodless and clear operation environment is provided for doctors, so that the operation is conveniently implemented.
However, the utilization rate of the silk membrane structure in the conventional membrane oxygenator is not high, and mainly because of poor blood diversion and diffusion efficiency, blood is easy to accumulate at a certain position in the membrane oxygenator and only flows through a certain position of the silk membrane structure, and blood cannot flow through other positions of the silk membrane structure.
Disclosure of Invention
Based on the above, it is necessary to provide a spiral diversion integrated membrane oxygenator capable of improving the utilization rate of the silk membrane structure and ensuring the diversion diffusion efficiency of blood aiming at the problem of low utilization rate of the current silk membrane structure.
A spiral-flow-directing integrated membrane oxygenator comprising:
a lower cover having an air outlet pipe;
the oxygenation part is arranged above the lower cover and comprises a mandrel structure, an oxygenation shell and an oxygenation silk membrane structure arranged between the mandrel structure and the oxygenation shell, wherein the oxygenation shell is provided with a blood outlet tube, and the blood outlet tube is close to the lower cover; and
the upper cover is arranged below the oxygenation part and opposite to the lower cover, the upper cover is provided with a blood inlet pipe and an oxygen inlet pipe, and the oxygen inlet pipe and the air outlet pipe are communicated with a space between the mandrel structure and the oxygenation shell;
the central spindle structure comprises a central spindle body and an annular flow guide plate, wherein the central spindle body is provided with a first end part and a second end part connected with the first end part, a blood channel is arranged between the first end part and an upper cover, the annular flow guide plate is sleeved on the central spindle body, the annular flow guide plate is provided with a plurality of flow guide perforations, and the plurality of flow guide perforations of the annular flow guide plate are distributed on the annular flow guide plate;
the oxygenation silk membrane structure comprises a plurality of hollow fiber layers, each hollow fiber layer is provided with a plurality of hollow fiber pipes, the hollow fiber pipes are inclined at an angle relative to a vertical plane, and the inclination direction of the hollow fiber pipes of each hollow fiber layer is different from that of the hollow fiber pipes of the adjacent hollow fiber layers and mutually intersected.
In an embodiment of the present application, the hollow fiber tube of the hollow fiber layer of each layer has an included angle of 15 degrees with the vertical plane.
In an embodiment of the present application, each of the flow guiding perforations of the annular flow guiding plate is a tapered hole, and a hole diameter of the flow guiding perforation located inside the annular flow guiding plate is smaller than a hole diameter of the flow guiding perforation located outside the annular flow guiding plate.
In an embodiment of the present application, the plurality of flow guiding perforations of the annular flow guiding plate includes at least one first flow guiding perforation and at least one second flow guiding perforation, the at least one first flow guiding perforation of the annular flow guiding plate is close to the lower cover, the at least one second flow guiding perforation of the annular flow guiding plate is located above the at least one first flow guiding perforation of the annular flow guiding plate and close to the upper cover, and the aperture of the at least one second flow guiding perforation of the annular flow guiding plate is larger than the aperture of the at least one first flow guiding perforation of the annular flow guiding plate.
In an embodiment of the present application, the inner surface of the annular flow guiding plate has a plurality of spiral flow guiding grooves arranged at intervals, a plurality of flow guiding perforations are located between a plurality of spiral flow guiding grooves, and each spiral flow guiding groove surrounds more than half a circle of the inner surface of the annular flow guiding plate.
In an embodiment of the present application, a horizontal circumferential length from one end to the other end of each of the spiral diversion trenches is greater than a semicircular perimeter of the annular diversion plate, and a vertical distance from one end to the other end of each of the spiral diversion trenches is between one half and two thirds of a height of the annular diversion plate.
In an embodiment of the present application, the spiral diversion integrated membrane oxygenator further includes an annular partition plate, the annular partition plate is disposed between the mandrel structure and the oxygenation housing, and the annular partition plate is provided with a diversion structure for guiding blood to diffuse and flow; the lower cover is provided with a water inlet pipe, the upper cover is provided with a water outlet pipe, and the water inlet pipe and the water outlet pipe are communicated with a space between the annular partition plate and the mandrel structure; the oxygen inlet pipe and the air outlet pipe are communicated with the space between the annular partition plate and the oxygenation shell; the annular partition plate and the mandrel structure are provided with a variable temperature wire film structure, the annular partition plate and the oxygenation shell are provided with an oxygenation wire film structure, and the variable temperature wire film structure is identical to the oxygenation wire film structure.
In an embodiment of the present application, the annular partition plate has a plurality of blood ports arranged in an annular shape as a flow guiding structure, and the plurality of blood ports are close to the lower cover.
In an embodiment of the present application, a plurality of spiral diversion trenches are provided on an outer surface of the annular partition at intervals as a diversion structure, and the spiral diversion trenches are located on one side of the plurality of blood ports of the annular partition.
In an embodiment of the present application, one end of each of the spiral diversion trenches is communicated with the corresponding blood port.
In an embodiment of the present application, the annular partition plate has at least one flow guiding perforation as a flow guiding structure, and the flow guiding perforation is distributed on the corresponding annular partition plate.
In an embodiment of the present application, the spiral water conservancy diversion integrated film oxygenator still includes well annular baffle and outer annular baffle, outer annular baffle set up in the outside of well annular baffle, outer annular baffle is adjacent the oxygenation casing, the diameter of well annular baffle is less than the diameter of outer annular baffle, well annular baffle reaches outer annular baffle has respectively and regard a plurality of blood through openings of annular arrangement as the water conservancy diversion structure, a plurality of well annular baffle the setting position of blood through opening with a plurality of blood through openings of outer annular baffle are relative.
In an embodiment of the present application, the spiral water conservancy diversion integrated film oxygenator still includes well annular baffle and outer annular baffle, outer annular baffle set up in the outside of well annular baffle, outer annular baffle is adjacent the oxygenation casing, well annular baffle and outer annular baffle have a plurality of water conservancy diversion perforation respectively as the water conservancy diversion structure, a plurality of well annular baffle the water conservancy diversion perforated aperture is greater than the dabber structure the a plurality of annular water conservancy diversion perforated aperture of water conservancy diversion baffle, a plurality of outer annular baffle the water conservancy diversion perforated aperture is less than a plurality of well annular baffle the water conservancy diversion perforated aperture.
In an embodiment of the present application, the aperture of the middle annular baffle, the plurality of flow guiding perforations of the outer annular baffle, and the plurality of flow guiding perforations of the annular baffle is greater than 3mm, and the shortest distance between the center of the flow guiding perforation of the outer annular baffle adjacent to the outlet vessel and the center of the blood vessel is greater than 5mm.
In an embodiment of the present application, the inner surface of the middle annular partition plate and the inner surface of the outer annular partition plate are further provided with a plurality of spiral diversion trenches arranged at intervals as a diversion structure, and the middle annular partition plate and the plurality of diversion perforations of the outer annular partition plate are respectively located in the middle annular partition plate and the plurality of spiral diversion trenches of the outer annular partition plate.
In an embodiment of the present application, a horizontal circumferential length from one end to the other end of each spiral flow guiding groove is greater than a semicircular circumference of the middle annular partition plate or the outer annular partition plate, and a vertical distance from one end to the other end of each spiral flow guiding groove is between one half and two thirds of a height of the middle annular partition plate or the outer annular partition plate.
In an embodiment of the present application, the oxygenation portion further includes an upper blocking structure and a lower blocking structure, the lower blocking structure is disposed on the mandrel structure in a penetrating manner and covers the lower cover, the upper blocking structure is disposed on the mandrel structure in a penetrating manner and is disposed below the upper cover, and the upper blocking structure and the lower blocking structure are disposed opposite to each other and are both disposed between the mandrel structure and the oxygenation casing.
The dabber structure of this application has annular guide plate, and annular guide plate is through having the perforated water conservancy diversion structure guide blood flow of water conservancy diversion to do the reposition of redundant personnel to blood, increase the diffusion area of blood, increase the area of contact of blood and silk membrane structure, effectively promote the utilization ratio of silk membrane structure, promote the oxygenation efficiency of diaphragm type oxygenator simultaneously. At the same time, the hollow fiber tubes of each hollow fiber layer can reduce the blood pre-charge. When blood flows into two adjacent hollow fiber layers of the silk membrane structure, the blood can be split into thinner blood membranes, the contact area of the blood and oxygen is increased, and the oxygenation efficiency of the blood and the oxygen is improved.
Drawings
Fig. 1 is a perspective view of a spiral-flow-guided integrated membrane oxygenator according to a first embodiment of the present application.
Fig. 2 is an assembled view of a spiral-flow-guided integrated membrane oxygenator according to a first embodiment of the present application.
Fig. 3 is a cross-sectional view of a spiral-flow-guided integrated membrane oxygenator according to a first embodiment of the present application.
Fig. 4 is an assembly view of a spiral-flow-guided integrated membrane oxygenator according to a second embodiment of the present application.
Fig. 5 is a cross-sectional view of a spiral-flow-guided integrated membrane oxygenator in accordance with a second embodiment of the present application.
Fig. 6 is a schematic view of a mandrel structure according to a third embodiment of the present application.
Fig. 7 is a schematic view of an annular separator according to a fourth embodiment of the present application.
Fig. 8 is a cross-sectional view of a spiral-flow-guided integrated membrane oxygenator in accordance with a fifth embodiment of the present application.
Fig. 9 is a schematic view of an intermediate annular separator according to a sixth embodiment of the present application.
Fig. 10 is a schematic view of an outer annular separator according to a sixth embodiment of the present application.
Fig. 11 is a cross-sectional view of a mandrel structure according to a seventh embodiment of the present application.
Fig. 12 is a schematic view of a silk film structure according to an eighth embodiment of the present application.
Detailed Description
In order to make the above objects, features and advantages of the present application more comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. This application is, however, susceptible of embodiment in many other forms than those described herein and similar modifications can be made by those skilled in the art without departing from the spirit of the application, and therefore the application is not to be limited to the specific embodiments disclosed below.
In the description of the present application, it should be understood that, if there are terms such as "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., these terms refer to the orientation or positional relationship based on the drawings, which are merely for convenience of description and simplification of description, and do not indicate or imply that the apparatus or element referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
Furthermore, the terms "first," "second," and the like, if any, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the terms "plurality" and "a plurality" if any, mean at least two, such as two, three, etc., unless specifically defined otherwise.
In this application, unless explicitly stated and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly. For example, the two parts can be fixedly connected, detachably connected or integrated; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art as the case may be.
In this application, unless expressly stated or limited otherwise, the meaning of a first feature being "on" or "off" a second feature, and the like, is that the first and second features are either in direct contact or in indirect contact through an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
It will be understood that if an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. If an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein, if any, are for descriptive purposes only and do not represent a unique embodiment.
Referring to fig. 1, 2 and 3, a perspective view, an assembled view and a sectional view of a spiral guide integrated membrane oxygenator 1 according to a first embodiment of the present application are shown; as shown in the drawing, the present embodiment provides a spiral-flow-guide integrated membrane oxygenator 1, and the spiral-flow-guide integrated membrane oxygenator 1 includes a lower cover 10, an oxygenation portion 11, and an upper cover 12, wherein the oxygenation portion 11 is disposed between the lower cover 10 and the upper cover 12. The lower cover 10 includes a lower cover housing 101, a first lower annular support piece 102a, a second lower annular support piece 102b, an air outlet pipe 103, and an air inlet pipe 104, and the lower cover housing 101 has a lower surface 1011 and a lower annular side wall 1012 surrounding the lower surface 1011. The first lower annular supporting piece 102a and the second lower annular supporting piece 102b are disposed on the lower surface 1011 of the lower cover housing 101, the second lower annular supporting piece 102b is located outside the first lower annular supporting piece 102a and in the lower annular side wall 1012, the diameter of the first lower annular supporting piece 102a is smaller than that of the second lower annular supporting piece 102b, and the center of the first lower annular supporting piece 102a, the center of the second lower annular supporting piece 102b and the center of the lower cover 10 are located on the same line, that is, the first lower annular supporting piece 102a and the second lower annular supporting piece 102b are concentrically arranged in the lower cover housing 101. The air outlet pipe 103 is provided on the lower surface 1011 of the lower cover case 101 and communicates with the space between the second lower annular supporting piece 102b and the lower annular side wall 1012. The water inlet pipe 104 is disposed on the lower annular sidewall 1012 and penetrates through the lower annular sidewall 1012 and the second lower annular supporting piece 102b, and the water inlet pipe 104 is communicated with the space between the second lower annular supporting piece 102b and the first lower annular supporting piece 102 a.
The oxygenation unit 11 includes a mandrel structure 110, an annular partition 111, an oxygenation housing 112, a lower blocking structure 113, a temperature-changing wire film structure 114, an oxygenation wire film structure 115, and an upper blocking structure 116, where the mandrel structure 110 is disposed on the first lower annular supporting sheet 102a and is located in the first lower annular supporting sheet 102 a. The annular spacer 111 is disposed on the second lower annular support plate 102b and is located outside of the mandrel structure 110. The oxygenation housing 112 is disposed on the lower annular sidewall 1012 of the lower cover housing 101, and has a blood outlet tube 1121 and a circulation exhaust tube 1122, wherein the blood outlet tube 1121 is close to the lower cover 10, the circulation exhaust tube 1122 is located above the blood outlet tube 1121 and is far from the lower cover 10, and the blood outlet tube 1121 and the circulation exhaust tube 1122 are communicated with the space between the mandrel structure 110 and the oxygenation housing 112. The lower blocking structure 113 is disposed on the mandrel structure 110 and covers the lower cover 10, and is located between the mandrel structure 110 and the oxygenation housing 112. The temperature-changing wire film structure 114 is arranged on the mandrel structure 110 in a penetrating manner, is arranged on the lower blocking structure 113 and is positioned between the mandrel structure 110 and the annular partition 111, so that a temperature-changing area is formed between the mandrel structure 110 and the annular partition 111. The oxidized fiber membrane structure 115 is disposed through the mandrel structure 110 and on the lower blocking structure 113 and between the annular partition 111 and the oxidized shell 112, such that an oxidized area is formed between the annular partition 111 and the oxidized shell 112. The upper blocking structure 116 is disposed on the mandrel structure 110, on the temperature-changing wire film structure 114 and the oxidized wire film structure 115, and between the mandrel structure 110 and the oxidized shell 112.
The annular partition 111 of the present embodiment has a plurality of blood ports 1111 arranged in an annular shape, the plurality of blood ports 1111 serving as a flow guide structure, and the plurality of blood ports 1111 being close to the lower cover 10. The annular partition 111 of the present embodiment mainly achieves the supporting function, and extends the blood diffusion path, increases the contact area and diffusion area between the blood and the temperature change wire film structure 114 and the oxidized wire film structure 115, and further increases the utilization rate of the temperature change wire film structure 114 and the oxidized wire film structure 115.
The upper cover 12 includes an upper cover housing 121, a first upper annular supporting piece 122a, a second upper annular supporting piece 122b, a blood inlet tube 124, an oxygen inlet tube 125 and a water outlet tube 126, and the upper cover housing 121 has an upper surface 1211 and an upper annular sidewall 1212 encircling the upper surface 1211. The first upper annular supporting piece 122a and the second upper annular supporting piece 122b are disposed on the upper surface 1211 of the upper cover housing 121, the second upper annular supporting piece 122b is located outside the first upper annular supporting piece 122a, the first upper annular supporting piece 122a and the second upper annular supporting piece 122b are located in the upper annular side wall 1212, and the centers of the first upper annular supporting piece 122a and the second upper annular supporting piece 122b and the center of the upper cover housing 121 are located on the same line. The blood inlet tube 124 is disposed on the upper annular sidewall 1212 of the upper cover housing 121, penetrates through the upper annular sidewall 1212, the second upper annular supporting plate 122b and the first upper annular supporting plate 122a, and is communicated with the space in the first upper annular supporting plate 122 a. The oxygen inlet tube 125 is disposed on the upper annular sidewall 1212 of the upper cover housing 121, penetrates through the upper annular sidewall 1212, and communicates with the space between the upper annular sidewall 1212 and the second upper annular supporting plate 122 b. The water outlet pipe 126 is disposed on the upper annular sidewall 1212 of the upper cover housing 121, penetrates through the upper annular sidewall 1212 and the second upper annular supporting plate 122b, and communicates with a space between the first upper annular supporting plate 122a and the second upper annular supporting plate 122 b.
When the upper cover 12 is disposed on the oxygenation portion 11, the first upper annular supporting piece 122a and the second upper annular supporting piece 122b are concentrically arranged in the upper cover housing 121, the first lower annular supporting piece 102a corresponds to the first upper annular supporting piece 122a, the second lower annular supporting piece 102b corresponds to the second upper annular supporting piece 122b, the upper annular sidewall 1212 of the upper cover housing 121 corresponds to the lower annular sidewall 1012 of the lower cover housing 101, and the upper annular sidewall 1212 of the upper cover housing 121, the second upper annular supporting piece 122b and the first upper annular supporting piece 122a are respectively engaged with the oxygenation housing 112 of the oxygenation portion 11, the annular partition 111 and the annular deflector 1102 of the mandrel structure 110. The centers of the lower cap 10, the oxidized part 11 and the upper cap 12 are located on the same line. The first end 1101a of mandrel body 1101 has a smaller outer diameter than the second end 1101b thereof such that a blood passageway is formed between first end 1101a of mandrel body 1101 and annular baffle 1102, which blood passageway communicates with upper cap 12, and which blood passageway flows outwardly of mandrel structure 110.
The space between the first lower annular supporting piece 102a and the second lower annular supporting piece 102b of the lower cover housing 101 and the space between the first upper annular supporting piece 122a and the second upper annular supporting piece 122b of the upper cover housing 121 correspond to the space between the mandrel structure 110 and the annular partition 111, and the water inlet pipe 104 of the lower cover 10 and the water outlet pipe 126 of the upper cover 12 are communicated with the space between the mandrel structure 110 and the annular partition 111. The space between the lower annular sidewall 1012 of the lower cover housing 101 and the second lower annular supporting piece 102b and the space between the upper annular sidewall 1212 of the upper cover housing 121 and the second upper annular supporting piece 122b correspond to the space between the mandrel structure 110 and the oxygenation housing 112, and the oxygen inlet pipe 125 of the upper cover 12 and the air outlet pipe 103 of the lower cover 10 communicate with the space between the mandrel structure 110 and the oxygenation housing 112.
In use of the spiral-flow-guide integrated-membrane oxygenator 1 of the present embodiment, blood from the extracorporeal blood circuit device enters the blood passageway of the mandrel body 1101 from the blood inlet 124 of the spiral-flow-guide integrated-membrane oxygenator 1. As blood enters the blood passageway, the blood flows down along the outer surface of the shaft 1101. Then, the blood flows from the plurality of flow guiding holes 11021 of the annular flow guiding plate 1102 to the temperature changing wire film structure 114, wherein the plurality of flow guiding holes 11021 shunt the blood, the blood flow in the single flow guiding hole 11021 and the flow velocity thereof are reduced, and the blood flowing out of each flow guiding hole 11021 can be gently contacted with the temperature changing wire film structure 114; in addition, radial flow guiding is achieved through the plurality of flow guiding holes 11021, so that the contact area and the diffusion area of the blood and the temperature changing wire film structure 114 are increased, the utilization rate of the temperature changing wire film structure 114 is improved, and the pressure of the spiral flow guiding integrated film oxygenator 1 is reduced, in other words, the annular flow guiding plate 1102 of the embodiment has a flow guiding structure formed by the plurality of flow guiding holes 11021, so as to achieve the above-mentioned effects.
When blood enters the temperature change wire membrane structure 114, water with a modulated temperature is simultaneously introduced from the water inlet pipe 104 of the lower cover 10, and the water with the modulated temperature flows from one end of the temperature change wire membrane structure 114 close to the lower cover 10 to the other end of the temperature change wire membrane structure 114 close to the upper cover 10, and the temperature of the blood diffused in the temperature change wire membrane structure 114 is adjusted by the temperature of the water. The blood having diffused into the temperature-changing yarn membrane structure 114 and having been subjected to temperature adjustment flows toward the lower cover 10, flows into the plurality of blood ports 1111 of the annular partition 111, and diffuses toward the oxidized yarn membrane structure 115.
When blood flows into the oxygenation filament membrane structure 115, oxygen is fed from the oxygen inlet tube 125 to the space between the second upper annular support piece 122b and the oxygenation housing 112, in other words, the oxygen in the oxygen inlet tube 125 is oxygenated with the blood in the oxygenation filament membrane structure 115 to replace carbon dioxide in the blood, carbon dioxide is generated during the oxygenation process, and the carbon dioxide sinks to the lower cover 10 and is discharged from the air outlet tube 103 of the lower cover 10. Finally, oxygenated blood is expelled from the blood tube 1121 of the oxygenation housing 112.
The temperature-changing filament membrane structure 114 and the oxidized filament membrane structure 115 each include a plurality of hollow fiber layers, the hollow fiber tube of each hollow fiber layer has a circular, square or oval cross section, and the gas generated when the hollow fiber of each layer is broken is discharged from the circulation exhaust pipe 1122 of the oxidized shell 112. The lower barrier structure 113 and the upper barrier structure 116 block blood located within the temperature change wire membrane structure 114 and the oxygenation wire membrane structure 115 from moving toward the lower cover 10 or the upper cover 12.
Please refer to fig. 4 and 5, which are an assembly view and a cross-sectional view of a spiral guide integrated membrane oxygenator 1 according to a second embodiment of the present application; as shown in the drawing, the spiral-flow-guide integrated-type membrane oxygenator 1 of the present embodiment is different from the spiral-flow-guide integrated-type membrane oxygenator of the above embodiment in that the spiral-flow-guide integrated-type membrane oxygenator 1 of the present embodiment omits the installation of the temperature change region, that is, the installation of the water inlet pipe of the lower cover 10, the second lower annular supporting piece of the lower cover 10, the annular partition plate, the second upper annular supporting piece of the upper cover 12, and the water outlet pipe of the upper cover 12. The oxidized fiber membrane structure 115 is directly disposed between the mandrel structure 110 and the oxidized shell 112, and the air outlet pipe 103 of the lower cover 10 and the air inlet pipe 125 of the upper cover 12 are respectively connected to the space between the mandrel structure 110 and the oxidized shell 112, so that the space between the mandrel structure 110 and the oxidized shell 112 forms an oxidized area.
Please refer to fig. 6, which is a schematic diagram of a mandrel structure 110 according to a third embodiment of the present application; as shown in the drawing, the flow guiding structure of the annular flow guiding plate 1102 of the mandrel structure 110 of the present embodiment includes a plurality of first flow guiding holes 11021a and a plurality of second flow guiding holes 11021b, wherein the plurality of first flow guiding holes 11021a are close to the lower cover 10, i.e. are distributed below the annular flow guiding plate 1102; the second flow guiding holes 11021b are distributed above the annular flow guiding plate 1102, that is, above the first flow guiding holes 11021a and close to the upper cover 12, and the apertures of the second flow guiding holes 11021b are larger than those of the first flow guiding holes 11021 a.
Referring to fig. 7, a schematic view of an annular partition 111 according to a fourth embodiment of the present application is shown; as shown in the figure, in the first embodiment, the outer surface of the annular partition 111 has a flow guiding structure, which is a plurality of spiral flow guiding grooves 1112 arranged at intervals, and the plurality of spiral flow guiding grooves 1112 of the annular partition 111 are located at one side of the plurality of blood ports 1111 of the annular partition 111, and even one end of each spiral flow guiding groove 1112 is communicated with the corresponding blood port 1111. The horizontal circumferential length of one end and the other end of each spiral guide groove 1112 is greater than the semicircular circumference of the annular partition 111, in other words, each spiral guide groove 1112 surrounds more than half a turn of the annular partition 111; the vertical distance between the two ends of each spiral guide groove 1112 is between the height of one-half of the annular partition 111 and the height of two-thirds of the annular partition 111. The plurality of spiral guide grooves 1112 of the annular partition 111 guide the blood to flow and are diffused to fill the plurality of spiral guide grooves 1112, so that the diffusion area of the blood is increased to be fully contacted with the oxygenation filament membrane structure, and the contact area between the oxygenation filament membrane structure and the blood and the utilization rate of the oxygenation filament membrane structure are increased. However, one end of each spiral guide groove 1112 is connected to the corresponding blood port 1111, so that blood flows from the plurality of blood ports 1111 and can flow into the plurality of spiral guide grooves 1112 in real time, and the blood fills the whole spiral guide grooves 1112 rapidly.
Referring to fig. 8, a cross-sectional view of a spiral guide integrated membrane oxygenator 1 according to a fifth embodiment of the present disclosure; as shown in the drawing, the number of the annular spacers in this embodiment is two, the two annular spacers are hereinafter referred to as an annular spacer 111a and an annular spacer 111b, the diameter of the annular spacer 111a is smaller than that of the annular spacer 111b, the annular spacer 111a is fixed by the corresponding second lower annular support piece 102b and second upper annular support piece 122b, the annular spacer 111b is fixed by the lower annular sidewall 1012 of the lower cover housing 101 and the upper annular sidewall 1212 of the upper cover housing 121, and the annular spacer 111b surrounds the oxidized wire film structure 115. The middle annular partition plate 111a and the outer annular partition plate 111b of the present embodiment each have a flow guide structure formed of a plurality of blood ports 1111 arranged in an annular shape, and the positions of the plurality of blood ports 1111 of the middle annular partition plate 111a are opposite to the positions of the plurality of blood ports 1111 of the outer annular partition plate 111b, the plurality of blood ports 1111 of the middle annular partition plate 111a of the present embodiment are close to the lower cover 10, and the plurality of blood ports 1111 of the outer annular partition plate 111b are close to the upper cover 12. The spiral diversion integrated membrane oxygenator 1 of the present embodiment increases the number of annular separators, increases the diffusion distance between blood and the temperature change wire membrane structures 114 and the oxygenation wire membrane structures 115, increases the contact area and the diffusion area between the blood and the plurality of temperature change wire membrane structures 114 and the oxygenation wire membrane structures 115, and increases the utilization rate of the temperature change wire membrane structures 114 and the oxygenation wire membrane structures 115. In addition, the plurality of blood ports 1111 of the outer annular partition 111b are distant from the blood vessel 1121, and the blood is prevented from directly flowing into the blood vessel 1121 from the plurality of blood ports 1111 of the outer annular partition 111b, thereby further improving the utilization ratio of the temperature change wire film structure 114 and the oxidized wire film structure 115. The surface of the outer annular partition 111b of the present embodiment is further provided with a filter for removing blood particles and gas micro-emboli.
Referring to fig. 9 and 10, a schematic view of an annular partition 111a and a schematic view of an annular partition 111b according to a sixth embodiment of the present disclosure are shown; as shown in the drawing, in the fifth embodiment, the middle annular partition 111a and the outer annular partition 111b of the present embodiment have a plurality of flow guide perforations 1113 uniformly distributed, and the middle annular partition 111a and the outer annular partition 111b of the present embodiment have a plurality of flow guide perforations 1113, respectively, so that the arrangement of a plurality of blood ports of the middle annular partition 111a and the outer annular partition 111b can be omitted. The aperture of the plurality of flow guiding perforations 1113 of the middle annular partition 111a is larger than the aperture of the plurality of flow guiding perforations of the annular flow guiding plate of the mandrel structure, the aperture of the plurality of flow guiding perforations 1113 of the outer annular partition 111b is smaller than the aperture of the plurality of flow guiding perforations 1113 of the middle annular partition 111a, and the aperture of the plurality of flow guiding perforations 1113 of the middle annular partition 111a and the outer annular partition 111b and the aperture of the plurality of flow guiding perforations of the annular flow guiding plate are larger than 3mm. Of course, the outer annular partition 111b may be omitted, or the outer annular partition 111b may be identical to that of the fifth embodiment, and will not be described again.
The plurality of flow-guiding perforations 1113 of the middle annular partition 111a and the outer annular partition 111b mainly guide the flow of blood and split the flow of blood, and the flow rate and flow rate of blood in the single flow-guiding perforation 1113 are reduced, and the blood flowing out from each flow-guiding perforation 1113 can be gently contacted with the oxidized fiber membrane structure. However, each of the flow guiding holes 1113 of the middle annular partition 111a of the present embodiment is a square hole, so that the blood is collected in the flow guiding holes 1113 of the middle annular partition 111a, and the flow guiding holes 1113 of the square holes can buffer the blood. The position of the outer annular partition 111b of the blood vessel 1121 corresponding to the oxygenation casing 112 is not provided with the diversion perforation 1113, that is, the shortest distance between the center of the diversion perforation 1113 of the outer annular partition 111b adjacent to the blood vessel 1121 and the center of the blood vessel 1121 is greater than 5mm, so that blood is prevented from directly flowing out of the diversion perforation 1113 adjacent to the blood vessel 1121, blood can flow out of the diversion perforation 1113 far from the blood vessel 1121, the utilization rate of the oxygenation wire membrane structure is improved, and the blood can be uniformly diffused.
The inner surfaces of the middle annular partition 111a and the outer annular partition 111b of the present embodiment are further provided with a plurality of spiral diversion trenches (as shown in fig. 11) disposed at intervals, and the plurality of diversion perforations 1113 of the middle annular partition 111a and the outer annular partition 111b are respectively located in the plurality of spiral diversion trenches of the middle annular partition 111a and the outer annular partition 111 b. Each spiral guide groove surrounds the inner surface of the middle annular partition 111a or the outer annular partition 111b by more than half a turn, in other words, the horizontal circumferential length from one end to the other end of each spiral guide groove is greater than the semicircular circumference of the middle annular partition 111a or the outer annular partition 111b, and the vertical distance of one end of each spiral guide groove is between one half of the height of the middle annular partition 111a or the outer annular partition 111b and two thirds of the height of the middle annular partition 111a or the outer annular partition 111 b.
Please refer to fig. 11, which is a cross-sectional view of a mandrel structure 110 according to a seventh embodiment of the present application; as shown in the drawing, the inner surface of the annular deflector 1102 of the mandrel structure 110 of the present embodiment has a plurality of spiral guide grooves 11022 disposed at intervals, a plurality of guide perforations 11021 are located between the plurality of spiral guide grooves 11022, each spiral guide groove 11022 surrounds more than half a circle of the inner surface of the annular deflector 1102, in other words, the horizontal circumferential length from one end of each spiral guide groove 11022 to the other end thereof is greater than the semicircular circumference of the annular deflector 1102, and the vertical distance from one end of each spiral guide groove 11022 to the other end thereof is between the height of one half of the annular deflector 1102 and the height of two thirds of the annular deflector 1102. However, first end 1101a of mandrel body 1101 has a flow guiding arcuate surface 11011, and one end of each spiral flow guiding groove 11022 is connected to flow guiding arcuate surface 11011, in other words, a plurality of spiral flow guiding grooves 11022 are located at one side of first end 1101a of mandrel body 1101 and correspond to second end 1101b of mandrel body 1101. Flow-guiding arcuate surface 11011 of mandrel body 1101 can buffer the flow rate of blood and guide the smooth flow of blood in the blood channel without blood accumulating at first end 1101a of mandrel body 1101. However, the plurality of spiral guide grooves 11022 are directly connected with the guide cambered surface 11011, the guide cambered surface 11011 can directly guide blood to the plurality of spiral guide grooves 11022, the plurality of spiral guide grooves 11022 guide blood to flow out from the plurality of guide perforations 11021 of the annular guide plate 1102, the plurality of guide perforations 11021 of the annular guide plate 1102 can uniformly flow out the blood again, the contact area and the diffusion area of the blood and the temperature changing wire film structure are increased, and the utilization rate of the temperature changing wire film structure is increased.
Please refer to fig. 12, which is a schematic diagram of a silk film structure 13 according to an eighth embodiment of the present application; as shown in the drawing, the filament membrane structure 13 of the present embodiment can be applied to the temperature-changing filament membrane structure and the oxidized filament membrane structure of the above embodiment, which includes a plurality of hollow fiber layers 131, each hollow fiber layer 131 having a plurality of hollow fiber tubes 1311, the plurality of hollow fiber tubes 1311 being inclined at an angle with respect to the vertical plane, the inclination direction of the plurality of hollow fiber tubes 1311 of each hollow fiber layer 131 being different from the inclination direction of the plurality of hollow fiber tubes 1311 of the adjacent hollow fiber layer 131, in other words, in which the plurality of hollow fiber tubes 1311 of one hollow fiber layer 131 and the plurality of hollow fiber tubes 1311 of the other hollow fiber layer 131 intersect each other, the hollow fiber tube 1311 of each hollow fiber layer 131 being inclined at an angle of 15 degrees with respect to the vertical plane. The hollow fiber tube 1311 of the hollow fiber layer 131 of each layer has an elliptical cross section, so that the blood pre-charge amount can be reduced. When blood flows into the space between two adjacent hollow fiber layers 131 of the silk membrane structure 13, the blood can be split into thinner blood membranes, the contact area between the blood and the oxygen is increased, and the oxygenation efficiency of the blood and the oxygen is improved.
The number of the annular baffle, the annular partition, the middle annular partition, the flow guide perforation of the outer annular partition, the blood port or the spiral flow guide groove in the above embodiment is one. In addition, the shortest distance between the center of the flow-guiding perforation of the middle annular barrier 111 adjacent to the outlet vessel and the center of the outlet vessel is greater than 5mm.
In summary, the application provides a spiral water conservancy diversion integrated film oxygenator, the dabber structure has annular guide plate, and annular guide plate is through the water conservancy diversion structure guide blood flow that has water conservancy diversion perforation or/and spiral guiding gutter to shunt blood, increase the diffusion area of blood, increase the area of contact of blood and silk membrane structure, effectively promote the utilization ratio of silk membrane structure, promote the oxygenation efficiency of spiral water conservancy diversion integrated film oxygenator simultaneously. The spiral flow-guiding integrated membrane oxygenator can be provided with at least one annular baffle, the annular baffle can support the spiral flow-guiding integrated membrane oxygenator, and meanwhile, the spiral flow-guiding integrated membrane oxygenator is provided with a flow-guiding structure of a flow-guiding perforation or/and a spiral flow-guiding groove, and the flow-guiding structure of the spiral flow-guiding integrated membrane oxygenator and the flow-guiding structure of the annular flow-guiding plate have the same function. The adjacent two hollow fiber layers of the silk membrane structure have small spacing, and can split the blood, so that the blood forms a thinner blood membrane, and the oxygenation efficiency of the blood and oxygen is improved. The hollow fiber tube of each hollow fiber layer has a circular, square or oval cross section, so that the amount of blood pre-charge can be reduced.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples only represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the claims. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application is to be determined by the claims appended hereto.
Claims (17)
1. A spiral-flow-directing integrated membrane oxygenator, comprising:
a lower cover having an air outlet pipe;
the oxygenation part is arranged above the lower cover and comprises a mandrel structure, an oxygenation shell and an oxygenation silk membrane structure arranged between the mandrel structure and the oxygenation shell, wherein the oxygenation shell is provided with a blood outlet tube, and the blood outlet tube is close to the lower cover; and
The upper cover is arranged below the oxygenation part and opposite to the lower cover, the upper cover is provided with a blood inlet pipe and an oxygen inlet pipe, and the oxygen inlet pipe and the air outlet pipe are communicated with a space between the mandrel structure and the oxygenation shell;
the central spindle structure comprises a central spindle body and an annular flow guide plate, wherein the central spindle body is provided with a first end part and a second end part connected with the first end part, a blood channel is arranged between the first end part and an upper cover, the annular flow guide plate is sleeved on the central spindle body, the annular flow guide plate is provided with a plurality of flow guide perforations, and the plurality of flow guide perforations of the annular flow guide plate are distributed on the annular flow guide plate;
the oxygenation silk membrane structure comprises a plurality of hollow fiber layers, each hollow fiber layer is provided with a plurality of hollow fiber pipes, the hollow fiber pipes are inclined at an angle relative to a vertical plane, and the inclination direction of the hollow fiber pipes of each hollow fiber layer is different from that of the hollow fiber pipes of the adjacent hollow fiber layers and mutually intersected.
2. The spiral-flow-directing integrated-membrane oxygenator as claimed in claim 1, wherein the hollow fiber tubes of the hollow fiber layers of each layer are angled at 15 degrees from the vertical.
3. The spiral-guide integrated membrane oxygenator according to claim 1, wherein each of the guide perforations of the annular guide plate is a tapered hole, and the diameter of the guide perforation located inside the annular guide plate is smaller than the diameter of the guide perforation located outside the annular guide plate.
4. The spiral membrane integrated-type oxygenator according to claim 1, wherein the plurality of flow-guiding perforations of the annular flow-guiding plate comprises at least one first flow-guiding perforation and at least one second flow-guiding perforation, the at least one first flow-guiding perforation of the annular flow-guiding plate is close to the lower cover, the at least one second flow-guiding perforation of the annular flow-guiding plate is located above the at least one first flow-guiding perforation of the annular flow-guiding plate and close to the upper cover, and the aperture of the at least one second flow-guiding perforation of the annular flow-guiding plate is larger than the aperture of the at least one first flow-guiding perforation of the annular flow-guiding plate.
5. The spiral guide integrated membrane oxygenator according to claim 1, wherein the inner surface of the annular guide plate is provided with a plurality of spiral guide grooves arranged at intervals, a plurality of guide perforations are positioned among a plurality of the spiral guide grooves, and each spiral guide groove surrounds more than half a circle of the inner surface of the annular guide plate.
6. The spiral guide integrated membrane oxygenator according to claim 5, wherein a horizontal circumferential length from one end of each of the spiral guide grooves to the other end thereof is greater than a semicircular circumference of the annular guide plate, and a vertical distance from one end of each of the spiral guide grooves to the other end thereof is between one-half and two-thirds of a height of the annular guide plate.
7. The spiral-flow-directing integrated-membrane oxygenator of claim 1 further comprising an annular baffle disposed between the mandrel structure and the oxygenation housing, and wherein the annular baffle is provided with a flow-directing structure for directing blood diffusion flow; the lower cover is provided with a water inlet pipe, the upper cover is provided with a water outlet pipe, and the water inlet pipe and the water outlet pipe are communicated with a space between the annular partition plate and the mandrel structure; the oxygen inlet pipe and the air outlet pipe are communicated with the space between the annular partition plate and the oxygenation shell; the annular partition plate and the mandrel structure are provided with a variable temperature wire film structure, the annular partition plate and the oxygenation shell are provided with an oxygenation wire film structure, and the variable temperature wire film structure is identical to the oxygenation wire film structure.
8. The spiral membrane oxygenator according to claim 7, wherein the annular partition has a plurality of blood ports arranged in an annular shape as a flow guiding structure, the plurality of blood ports being adjacent to the lower cover.
9. The spiral guide integrated membrane oxygenator according to claim 8, wherein a plurality of spiral guide grooves are provided at intervals on an outer surface of the annular partition plate as a guide structure, and the spiral guide grooves are located on one side of a plurality of blood ports of the annular partition plate.
10. The spiral-guide integrated-membrane oxygenator according to claim 9, wherein one end of each of the spiral guide grooves communicates with the corresponding blood port.
11. The spiral membrane integrated-type oxygenator according to claim 7, wherein the annular partition plate has at least one flow guide perforation as a flow guide structure, the flow guide perforation being distributed in the corresponding annular partition plate.
12. The spiral membrane-type oxygenator according to claim 1, further comprising a middle annular partition plate and an outer annular partition plate, wherein the outer annular partition plate is arranged on the outer side of the middle annular partition plate, the outer annular partition plate is adjacent to the oxygenation shell, the diameter of the middle annular partition plate is smaller than that of the outer annular partition plate, the middle annular partition plate and the outer annular partition plate are respectively provided with a plurality of blood through holes which are arranged in an annular mode to serve as a flow guiding structure, and the arrangement positions of the plurality of blood through holes of the middle annular partition plate are opposite to the arrangement positions of the plurality of blood through holes of the outer annular partition plate.
13. The spiral membrane type integrated membrane oxygenator according to claim 1, further comprising a middle annular baffle plate and an outer annular baffle plate, wherein the outer annular baffle plate is arranged on the outer side of the middle annular baffle plate, the outer annular baffle plate is adjacent to the oxygenation shell, the middle annular baffle plate and the outer annular baffle plate are respectively provided with a plurality of flow guide through holes serving as flow guide structures, the aperture of the flow guide through holes of the middle annular baffle plate is larger than the aperture of the flow guide through holes of the annular baffle plate of the mandrel structure, and the aperture of the flow guide through holes of the outer annular baffle plate is smaller than the aperture of the flow guide through holes of the middle annular baffle plate.
14. The spiral membrane integrated-type oxygenator according to claim 13, wherein the apertures of the plurality of flow guide perforations of the middle annular baffle and the outer annular baffle and the plurality of flow guide perforations of the annular baffle are greater than 3mm, and the shortest distance between the center of the flow guide perforation of the outer annular baffle adjacent to the blood outlet tube and the center of the blood outlet tube is greater than 5mm.
15. The spiral membrane type oxygenator according to claim 13, wherein a plurality of spiral diversion trenches are further provided on the inner surfaces of the middle annular partition plate and the outer annular partition plate at intervals as a diversion structure, and the plurality of diversion perforations of the middle annular partition plate and the outer annular partition plate are respectively located in the plurality of spiral diversion trenches of the middle annular partition plate and the outer annular partition plate.
16. The spiral-flow-directing integrated membrane oxygenator according to claim 15, wherein a horizontal circumferential length from one end of each of the spiral-flow-directing grooves to the other end thereof is greater than a semicircular circumference of the middle annular partition or the outer annular partition, and a vertical distance from one end of each of the spiral-flow-directing grooves to the other end thereof is between one half and two thirds of a height of the middle annular partition or the outer annular partition.
17. The spiral guide integrated membrane oxygenator according to claim 15, wherein the oxygenating portion further comprises an upper blocking structure and a lower blocking structure, the lower blocking structure is arranged on the mandrel structure in a penetrating manner and covers the lower cover, the upper blocking structure is arranged on the mandrel structure in a penetrating manner and is arranged below the upper cover, and the upper blocking structure and the lower blocking structure are arranged oppositely and are located between the mandrel structure and the oxygenating shell.
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| CN201710817792.5A CN107362399B (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
| CN202310546603.0A CN116328070A (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
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| CN110575579A (en) * | 2019-09-23 | 2019-12-17 | 中国科学技术大学 | Dialysis-enhanced hemodialyzer capable of improving blood flow |
| CN111037853B (en) * | 2019-12-27 | 2022-09-23 | 东莞科威医疗器械有限公司 | Injection molding mold for spiral flow guide inner core of oxygenator |
| CN111701103B (en) * | 2020-06-29 | 2023-03-03 | 广东省心血管病研究所 | Pump-free artificial membrane lung for ECMO |
| CN111744065B (en) * | 2020-06-29 | 2023-07-18 | 东莞科威医疗器械有限公司 | Oxidized fiber film, oxidized part and oxygenator for ECMO |
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| US5632894A (en) * | 1994-06-24 | 1997-05-27 | Gish Biomedical, Inc. | Arterial blood filter with upwardly inclining delivery inlet conduit |
| US8518259B2 (en) * | 2011-01-27 | 2013-08-27 | Medtronic, Inc. | De-airing oxygenator for treating blood in an extracorporeal blood circuit |
| US10098994B2 (en) * | 2014-01-09 | 2018-10-16 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| CN208893292U (en) * | 2017-09-12 | 2019-05-24 | 东莞科威医疗器械有限公司 | A kind of spiral stream guidance integrated form membrane oxygenator |
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