CN107362399A - A kind of spiral stream guidance integrated form membrane oxygenator - Google Patents
A kind of spiral stream guidance integrated form membrane oxygenator Download PDFInfo
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- CN107362399A CN107362399A CN201710817792.5A CN201710817792A CN107362399A CN 107362399 A CN107362399 A CN 107362399A CN 201710817792 A CN201710817792 A CN 201710817792A CN 107362399 A CN107362399 A CN 107362399A
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- Prior art keywords
- oxygen
- stream guidance
- spiral stream
- water conservancy
- membrane
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- 239000012528 membrane Substances 0.000 title claims abstract description 148
- 239000008280 blood Substances 0.000 claims abstract description 94
- 210000004369 blood Anatomy 0.000 claims abstract description 94
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 93
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 92
- 239000001301 oxygen Substances 0.000 claims abstract description 92
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 92
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 26
- 238000009826 distribution Methods 0.000 claims abstract description 6
- 239000012510 hollow fiber Substances 0.000 claims description 16
- 235000012489 doughnuts Nutrition 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 abstract description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- 230000017531 blood circulation Effects 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 9
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 239000001569 carbon dioxide Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000006213 oxygenation reaction Methods 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 3
- 238000003491 array Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 239000010151 yanghe Substances 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000157 blood function Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000000287 tissue oxygenation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W10/00—Technologies for wastewater treatment
- Y02W10/10—Biological treatment of water, waste water, or sewage
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention relates to a kind of spiral stream guidance integrated form membrane oxygenator, and it, which includes lower cover, oxygen conjunction portion and upper lid, lower cover, has escape pipe；Oxygen conjunction portion is arranged at lower cover and closes housing and oxygen plying membrane structure including core shaft structure, oxygen, and oxygen, which closes housing, has blood vessel, goes out blood vessel close to lower cover；Upper lid is arranged at oxygen conjunction portion, and has into blood vessel and oxygen feeding tube；Wherein core shaft structure includes mandrel body and ring diversion plate, mandrel body has first end and the second end, there is blood channel between first end and upper lid, ring diversion plate is sheathed on mandrel body, there is ring diversion plate at least one water conservancy diversion to perforate, and at least one water conservancy diversion perforation distributions of ring diversion plate are on ring diversion plate.The core shaft structure of the spiral stream guidance integrated form membrane oxygenator of the application has ring diversion plate, ring diversion plate guides blood by the flow-guiding structure perforated with an at least water conservancy diversion and spread, increase blood and the contact area and diffusion area of cortina structure, lift the utilization rate of cortina structure.
Description
Technical field
The present invention relates to a kind of technical field of medical device product, more particularly to a kind of spiral stream guidance integrated form membrane type oxygen
Clutch.
Background technology
Membrane oxygenator is the medicine equipment that cardiac arrest replaces lung, has oxygen and carbon dioxide content in regulation blood
Function, be the indispensable Medical Devices of operation on vessels of heart, and treatment acute respiratory illness and wait the lung transplantation stage indispensable
Medical Devices.Membrane oxygenator principle be will outside internal venous blood lead body, after membrane oxygenator carry out oxygen and
Carbon dioxide exchange becomes arterial blood, then feeds back patient artery system, maintains the supply of human internal organ tissue oxygenation blood, is performing the operation
During temporarily substitute lung effect, while for doctor provide peace and quiet, without blood, clearly surgical environments, in order to implement to perform the operation.
But the utilization rate of the cortina structure in current membrane oxygenator is not high, mainly because of its blood water conservancy diversion diffuser efficiency
Bad, blood is easily piled up in certain in membrane oxygenator, and is only flowed through from certain of cortina structure, and blood will not be from
The other positions of cortina structure flow through.
The content of the invention
For deficiency of the prior art, it is an object of the invention to provide a kind of spiral stream guidance integrated form membrane oxygenator,
It includes：Lower cover, it has escape pipe；Oxygen conjunction portion, it is arranged at the lower cover, and closes housing including core shaft structure, oxygen and set
Be placed in the core shaft structure and oxygen and close oxygen plying membrane structure between housing, the oxygen, which closes housing, has a blood vessel, it is described go out blood vessel
Close to the lower cover；And upper lid, it is arranged at the oxygen conjunction portion, and has into blood vessel and oxygen feeding tube, the oxygen feeding tube and goes out
Tracheae connects the space between core shaft structure and oxygen the conjunction housing；Wherein described core shaft structure includes mandrel body and annular water conservancy diversion
Plate, the mandrel body have the second end of first end and the connection first end, had between the first end and upper lid
There is blood channel, the ring diversion plate is sheathed on the mandrel body, and there is the ring diversion plate at least one water conservancy diversion to perforate,
At least one water conservancy diversion perforation distributions of the ring diversion plate are on the ring diversion plate.
Compared with prior art, the application can be obtained including following technique effect：
The core shaft structure of the application has ring diversion plate, and ring diversion plate with water conservancy diversion perforation and/or spiral by leading
The flow-guiding structure guiding blood flow of chute, and blood is shunted, increase the diffusion area of blood, increase blood and cortina knot
The contact area of structure, effectively lifts the utilization rate of cortina structure, while lifts the oxygenation efficiency of membrane oxygenator.
Brief description of the drawings
Fig. 1 is the stereogram of the spiral stream guidance integrated form membrane oxygenator of the application first embodiment.
Fig. 2 is the assembling figure of the spiral stream guidance integrated form membrane oxygenator of the application first embodiment.
Fig. 3 is the profile of the spiral stream guidance integrated form membrane oxygenator of the application first embodiment.
Fig. 4 is the assembling figure of the spiral stream guidance integrated form membrane oxygenator of the application second embodiment.
Fig. 5 is the profile of the spiral stream guidance integrated form membrane oxygenator of the application second embodiment.
Fig. 6 is the schematic diagram of the core shaft structure of the embodiment of the application the 3rd
Fig. 7 is the schematic diagram of the toroidal membrane of the embodiment of the application the 4th.
Fig. 8 is the profile of the spiral stream guidance integrated form membrane oxygenator of the embodiment of the application the 5th.
Fig. 9 is the schematic diagram of the middle toroidal membrane of the embodiment of the application the 6th.
Figure 10 is the schematic diagram of the outer ring dividing plate of the embodiment of the application the 6th.
Figure 11 is the profile of the core shaft structure of the embodiment of the application the 7th.
Figure 12 is the schematic diagram of the cortina structure of the embodiment of the application the 8th.
Embodiment
Multiple embodiments of the application, as clearly stated, the details in many practices will be disclosed with schema below
It will be explained in the following description.It should be appreciated, however, that the details in these practices is not applied to limit the application.Also
It is to say, in some embodiments of the application, the details in these practices is non-essential.In addition, for the sake of simplifying schema,
Some known usual structures will illustrate it in a manner of simply illustrative in the drawings with component.
On its " first " used herein, " second " etc., the meaning of order or cis-position is not especially censured, also non-use
To limit the application, it is just for the sake of difference with the component of constructed term description or operation.
Fig. 1, Fig. 2 and Fig. 3 are referred to, it is the spiral stream guidance integrated form membrane oxygenator 1 of the application first embodiment
Stereogram, assembling figure and profile；As illustrated, present embodiment provides a kind of spiral stream guidance integrated form membrane oxygenator 1,
Spiral stream guidance integrated form membrane oxygenator 1 includes lower cover 10, oxygen conjunction portion 11 and upper lid 12, oxygen conjunction portion 11 be arranged at lower cover 10 with it is upper
Between lid 12.Lower cover 10 includes lower lid housing 101, first time annular brace piece 102a, second time annular brace piece 102b, escape pipe
103 and water inlet pipe 104, there is lower lid housing 101 lower surface 1011 and ring to set the lower annular sidewall 1012 on surface 1011.First
Lower annular brace piece 102a and second time annular brace piece 102b is arranged at the lower surface 1011 of lower lid housing 101, second time ring
For shape support chip 102b positioned at first time annular brace piece 102a outside, and in lower annular sidewall 1012, first time annular
Support chip 102a diameter is less than second time annular brace piece 102b diameter, first time annular brace piece 102a center, the
Two times annular brace piece 102b center is centrally located on same line with lower cover 10, i.e. first time annular brace piece 102a and the
Two times annular brace piece 102b in lower lid housing 101 in making concentric arrays.Escape pipe 103 is arranged under lower lid housing 101
Surface 1011, and the space between second time annular brace piece 102b and lower annular sidewall 1012 connects.Water inlet pipe 104 is arranged at
Lower annular sidewall 1012, and run through lower annular sidewall 1012 and second time annular brace piece 102b, under the connection of water inlet pipe 104 second
Space between annular brace piece 102b and first time annular brace piece 102a.
Oxygen conjunction portion 11 includes core shaft structure 110, toroidal membrane 111, oxygen and closes housing 112, lower barrier structure 113, alternating temperature silk
Membrane structure 114, oxygen plying membrane structure 115 and upper barrier structure 116, core shaft structure 110 are arranged at first time annular brace piece
102a, and in first time annular brace piece 102a.Toroidal membrane 111 is arranged at second time annular brace piece 102b, and position
In the outside of core shaft structure 110.Oxygen closes housing 112 and is arranged at the lower annular sidewall 1012 of lower lid housing 101, and has blood vessel
1121 and circulating exhaust pipe 1122, go out blood vessel 1121 close to lower cover 10, circulating exhaust pipe 1122 is located at the top of blood vessel 1121, and
Away from lower cover 10, the space gone out between blood vessel 1121 and the connection core shaft structure 110 of circulating exhaust pipe 1122 and oxygen conjunction housing 112.Under
Barrier structure 113 is arranged on core shaft structure 110 and is covered on lower cover 10, and closes housing 112 positioned at core shaft structure 110 and oxygen
Between.Alternating temperature cortina structure 114 is arranged in core shaft structure 110, and is arranged on lower barrier structure 113, and is located at core shaft structure 110
Between toroidal membrane 111, temperature-varying zone is formed between such core shaft structure 110 and toroidal membrane 111.Oxygen plying membrane structure 115 is worn
In core shaft structure 110, and it is arranged on lower barrier structure 113, and between toroidal membrane 111 and oxygen close housing 112, such ring
Shape dividing plate 111 and oxygen form Yang He areas between closing housing 112.Upper barrier structure 116 is arranged on core shaft structure 110, and is arranged at
In alternating temperature cortina structure 114 and oxygen plying membrane structure 115, and between core shaft structure 110 and oxygen close housing 112.
The core shaft structure 110 of present embodiment includes mandrel body 1101 and ring diversion plate 1102, and mandrel body 1101 has
First end 1101a and connection first end 1101a the second end 1101b, the second end 1101b external diameter are more than first end
Portion 1101a external diameter, the second end 1101b are arranged in first time annular brace piece 102a.Ring diversion plate 1102 is arranged in
Mandrel body 1101, and it is arranged at first time annular brace piece 102a of lower cover 10.There are ring diversion plate 1102 multiple water conservancy diversion to wear
Hole 11021, multiple water conservancy diversion perforation 11021 are uniformly distributed in ring diversion plate 1102.Each water conservancy diversion perforation of present embodiment
11021 be bellmouth, is less than positioned at the aperture of the water conservancy diversion perforation 11021 of the inner side of ring diversion plate 1102 and is located at ring diversion plate
The aperture of the water conservancy diversion perforation 11021 in 1102 outsides.The water conservancy diversion perforation 11021 of certain present embodiment or straight hole, in this not
Repeat again.
The toroidal membrane 111 of present embodiment has the multiple blood ports 1111 annularly arranged, multiple blood ports
1111 are used as flow-guiding structure, and multiple blood ports 1111 are close to lower cover 10.The toroidal membrane 111 of present embodiment mainly reaches branch
The effect of support, and extend the path of blood diffusion, increase blood and alternating temperature cortina structure 114 and oxygen plying membrane structure 115 connect
Contacting surface product and diffusion area, more lift the utilization rate of alternating temperature cortina structure 114 and oxygen plying membrane structure 115.
Upper lid 12 includes annular brace piece 122a on shell of top cover body 121, first, annular brace piece 122b on second, enters blood
There is upper surface 1211 and ring to set the upper annular of upper surface 1211 for pipe 124, oxygen feeding tube 125 and outlet pipe 126, shell of top cover body 121
Side wall 1212.Annular brace piece 122b is arranged at the upper surface of shell of top cover body 121 on annular brace piece 122a and second on first
1211, annular brace piece 122b annular brace piece 122a on the outside of annular brace piece 122a on first, first on second
And annular brace piece 122b is located in upper annular sidewall 1212 on second, annular branch on annular brace piece 122a and second on first
Blade 122b center is centrally located on same line with shell of top cover body 121.Enter blood vessel 124 and be arranged at the upper of shell of top cover body 121
Annular sidewall 1212, and the annular brace piece 122a on annular brace piece 122b and first on upper annular sidewall 1212, second,
And the space in connection first in annular brace piece 122a.Oxygen feeding tube 125 is arranged at the upper annular sidewall of shell of top cover body 121
1212, and run through upper annular sidewall 1212, and connect the space of annular brace piece 122b on upper annular sidewall 1212 and second.Go out
Water pipe 126 is arranged at the upper annular sidewall 1212 of shell of top cover body 121, and through annular brace on upper annular sidewall 1212 and second
Piece 122b, and connect the space on first on annular brace piece 122a and second between annular brace piece 122b.
When upper lid 12 is arranged at oxygen conjunction portion 11, on first on annular brace piece 122a and second annular brace piece 122b in
Making concentric arrays in shell of top cover body 121, first time annular brace piece 102a is corresponding with annular brace piece 122a on first, and second
Lower annular brace piece 102b is corresponding with annular brace piece 122b on second, the upper annular sidewall 1212 and lower cover of shell of top cover body 121
The correspondence of lower annular sidewall 1012 of housing 101, annular brace piece 122b on the upper annular sidewall 1212, second of shell of top cover body 121
And annular brace piece 122a is arranged in oxygen conjunction housing 112, toroidal membrane 111 and the core shaft structure in oxygen conjunction portion 11 respectively on first
110 ring diversion plate 1102.Lower cover 10, oxygen conjunction portion 11 and upper lid 12 are centrally located on same line.The of mandrel body 1101
One end 1101a external diameter is less than its second end 1101b external diameter, the first end 1101a and ring of such mandrel body 1101
The blood access toward flowing outside core shaft structure 110 is formed between shape deflector 1102, blood access is connected with upper lid 12.
Space and upper lid between first time annular brace piece 102a of lower lid housing 101 and second time annular brace piece 102b
The corresponding core shaft structure 110 in space on the first of housing 121 between annular brace piece 122a and annular brace piece 122b on second with
Space between toroidal membrane 111, the water inlet pipe 104 of lower cover 10 and the outlet pipe 126 of upper lid 12 connect core shaft structure 110 and annular
Space between dividing plate 111.Space between the lower annular sidewall 1012 of lower lid housing 101 and second time annular brace piece 102b and on
The corresponding core shaft structure 110 in space between the upper annular sidewall 1212 of lid housing 121 and annular brace piece 122b on second closes with oxygen
Space between housing 112, the oxygen feeding tube 125 of upper lid 12 and the escape pipe 103 of lower cover 10 connect core shaft structure 110 and close housing with oxygen
Space between 112.
The spiral stream guidance integrated form membrane oxygenator 1 of present embodiment is in use, the blood of extracorporeal blood circuit device
From the blood channel for entering blood vessel 124 and entering mandrel body 1101 of spiral stream guidance integrated form membrane oxygenator 1.When blood enters blood
During passage, blood flows from top to bottom along the outer surface of mandrel body 1101.Now blood is multiple from ring diversion plate 1102
Water conservancy diversion perforation 11021 flows to alternating temperature cortina structure 114, and plurality of water conservancy diversion perforation 11021 allows blood shunt, and single individual water conservancy diversion is worn
Blood flow in hole 11021 and its flow velocity reduce, from the blood of the outflow of each water conservancy diversion perforation 11021 can ease up and alternating temperature
Cortina structure 114 contacts；In addition, radial direction water conservancy diversion, increase blood and alternating temperature cortina are reached by multiple water conservancy diversion perforation 11021
The contact area and diffusion area of structure 114, the utilization rate of alternating temperature cortina structure 114 is improved, reduce spiral stream guidance integrated membrane
The pressure of formula oxygenator 1, in other words, the ring diversion plate 1102 of present embodiment have by 11021 institutes of multiple water conservancy diversion perforation
The flow-guiding structure of composition, to reach above-mentioned effect.
When blood enters alternating temperature cortina structure 114, while the water inlet pipe 104 of the water of modulated temperature from lower cover 10 is logical
Enter, the water of modulated temperature is from close to the past alternating temperature cortina structure close to upper lid 10 in one end of alternating temperature cortina structure 114 of lower cover 10
114 other ends are flowed, and the blood heat of alternating temperature cortina structure 114 is spread in by the adjustment of its temperature.Diffuse to alternating temperature cortina knot
The structure 114 and blood of adjusted temperature flows toward lower cover 10, then flowed into from multiple blood ports 1111 of toroidal membrane 111, blood
Liquid spreads toward oxygen plying membrane structure 115.
When right blood flows into oxygen plying membrane structure 115, oxygen is inputted to annular brace piece 122b on second from oxygen feeding tube 125
The space between housing 112 is closed with oxygen, in other words, oxygen and the blood in oxygen plying membrane structure 115 of oxygen feeding tube 125 carry out oxygen
Closing, replace out the carbon dioxide in blood, oxygen produces carbon dioxide during closing, and carbon dioxide sinks down into lower cover 10, and under
The escape pipe 103 of lid 10 is discharged.The blood vessel 1121 that goes out for most closing housing 112 from oxygen through the blood that oxygen closes afterwards is discharged.
Above-mentioned alternating temperature cortina structure 114 and oxygen plying membrane structure 115 include multilayer hollow fiber layer respectively, in each layer
The section of the hollow fiber conduit of hollow fiber layer is circular, square or oval, and every layer of doughnut is produced when rupture
Gas from oxygen close housing 112 circulating exhaust pipe 1122 discharge.Lower barrier structure 113 and upper barrier structure 116 barrier is located at
Blood in alternating temperature cortina structure 114 and oxygen plying membrane structure 115 moves toward lower cover 10 or upper lid 12.
Fig. 4 and Fig. 5 is referred to, it is the group of the spiral stream guidance integrated form membrane oxygenator 1 of the application second embodiment
Dress figure and profile；As illustrated, the spiral stream guidance integrated form membrane oxygenator 1 of present embodiment and the spiral shell of above-mentioned embodiment
Rotation water conservancy diversion integrated form membrane oxygenator difference is that the spiral stream guidance integrated form membrane oxygenator 1 of present embodiment omits alternating temperature
The setting in area, that is, omit the water inlet pipe of lower cover 10, second time annular brace piece of lower cover 10, toroidal membrane, the second of upper lid 12
The setting of the outlet pipe of upper annular brace piece and upper lid 12.Oxygen plying membrane structure 115 is directly arranged in core shaft structure 110 and closes shell with oxygen
Between body 112, the escape pipe 103 of lower cover 10 and the oxygen feeding tube 125 of upper lid 12 are respectively communicated with core shaft structure 110 and close housing 112 with oxygen
Between space, the space that such core shaft structure 110 and oxygen are closed between housing 112 forms Yang He areas.
Referring to Fig. 6, it is the schematic diagram of the core shaft structure 110 of the embodiment of the application the 3rd；As illustrated, this implementation
The flow-guiding structure of the ring diversion plate 1102 of the core shaft structure 110 of mode includes multiple first water conservancy diversion perforation 11021a and multiple the
The perforation of two water conservancy diversion 11021b, multiple first water conservancy diversion perforation 11021a are distributed in ring diversion plate 1102 close to lower cover 10, i.e. its
Lower section；Multiple second water conservancy diversion perforation 11021b are distributed in the top of ring diversion plate 1102, i.e., it is located at multiple first water conservancy diversion and worn
Simultaneously perforated close to upper lid 12, multiple second water conservancy diversion perforation 11021b aperture more than multiple first water conservancy diversion hole 11021a top
11021a aperture.
Referring to Fig. 7, it is the schematic diagram of the toroidal membrane 111 of the embodiment of the application the 4th；As illustrated, hold first
Embodiment, the outer surface of the toroidal membrane 111 of present embodiment have flow-guiding structure, and flow-guiding structure is spaced multiple
Spiral stream guidance groove 1112, multiple spiral stream guidance grooves 1112 of toroidal membrane 111 are located at multiple blood ports of toroidal membrane 111
1111 side, or even blood port 1111 corresponding to one end connection of each spiral stream guidance groove 1112.Each spiral is led
One end of chute 1112 is more than the semicircle girth of toroidal membrane 111 with the horizontal circumferential length of its other end, in other words, each
Individual spiral stream guidance groove 1112 is more than the half-turn of toroidal membrane 111；It is vertical between the both ends of each spiral stream guidance groove 1112
Distance is between the height of the toroidal membrane 111 of half and the height of 2/3rds toroidal membrane 111.Toroidal membrane
111 multiple spiral stream guidance grooves 1112 guiding blood flow, and spread and fill up multiple spiral stream guidance grooves 1112, increase the expansion of blood
Area is dissipated, fully to be contacted with oxygen plying membrane structure, increases oxygen plying membrane structure and the contact area and its utilization rate of blood.So
Blood port 1111 corresponding to one end connection of each spiral stream guidance groove 1112, such blood flow from multiple blood ports 1111
Enter and multiple spiral stream guidance grooves 1112 can be flowed into immediately, blood is rapidly full of whole spiral stream guidance groove 1112.
Referring to Fig. 8, it is the profile of the spiral stream guidance integrated form membrane oxygenator 1 of the embodiment of the application the 5th；
As illustrated, the quantity of the toroidal membrane of present embodiment is two, two toroidal membranes call middle toroidal membrane 111a and outer in the following text
Toroidal membrane 111b, middle toroidal membrane 111a diameter are less than outer ring dividing plate 111b diameter, and middle toroidal membrane 111a is by right
Annular brace piece 122b is fixed on the second time annular brace piece 102b answered and second, and outer ring dividing plate 111b is by lower lid housing
101 lower annular sidewall 1012 and the upper annular sidewall 1212 of shell of top cover body 121 are fixed, and outer ring dividing plate 111b is around oxygen plying
Membrane structure 115.Middle toroidal membrane 111a and outer ring the dividing plate 111b of present embodiment has with the multiple of annular arrangement respectively
The flow-guiding structure that blood port 1111 forms, the set location and outer ring of middle toroidal membrane 111a multiple blood ports 1111
The set location of dividing plate 111b multiple blood ports 1111 is relative, the middle toroidal membrane 111a of present embodiment multiple blood
Port 1111 is close to lower cover 10, and outer ring dividing plate 111b multiple blood ports 1111 are close to upper lid 12.The spiral shell of present embodiment
Revolving water conservancy diversion integrated form membrane oxygenator 1 increases the quantity of toroidal membrane, and increase blood is in alternating temperature cortina structure 114 and oxygen plying film
The diffusion length of structure 115, with increase the contact area of blood and multiple alternating temperature cortina structures 114 and oxygen plying membrane structure 115 and
Diffusion area, improve the utilization rate of alternating temperature cortina structure 114 and oxygen plying membrane structure 115.In addition, outer ring dividing plate 111b's is more
Individual blood port 1111 avoids blood straight from outer ring dividing plate 111b multiple blood ports 1111 to connecing away from blood vessel 1121 is gone out
Connect and flow into out blood vessel 1121, so more improve the utilization rate of alternating temperature cortina structure 114 and oxygen plying membrane structure 115.This embodiment party
The outer ring dividing plate 111b of formula surface is further provided with the filter for removing blood particle and gas microembolus.
Fig. 9 and Figure 10 is referred to, it is the middle toroidal membrane 111a of the embodiment of the application the 6th schematic diagram and outer shroud
Shape dividing plate 111b schematic diagram；As illustrated, the 5th embodiment is held, the middle toroidal membrane 111a and outer ring of present embodiment
Dividing plate 111b has equally distributed multiple water conservancy diversion perforation 1113 respectively, because of toroidal membrane 111a and outer shroud in present embodiment
Shape dividing plate 111b has multiple water conservancy diversion perforation 1113, therefore toroidal membrane 111a and outer ring dividing plate 111b in can omitting respectively
Multiple blood ports setting.The aperture of middle toroidal membrane 111a multiple water conservancy diversion perforation 1113 is more than the annular of core shaft structure
Deflector multiple water conservancy diversion perforation aperture, outer ring dividing plate 111b multiple water conservancy diversion perforation 1113 aperture be less than it is middle annular every
The aperture of plate 111a multiple water conservancy diversion perforation 1113, middle toroidal membrane 111a and outer ring dividing plate 111b multiple water conservancy diversion perforation
1113 and ring diversion plate multiple water conservancy diversion perforation aperture be more than 3mm.Certainly outer ring dividing plate 111b setting can be also omitted,
Or outer ring dividing plate 111b is identical with the outer ring dividing plate of the 5th embodiment, is repeated no more in this.
Middle toroidal membrane 111a and outer ring dividing plate 111b multiple water conservancy diversion 1113 main guide blood flows of perforation, and will
Blood shunt, blood flow and its flow velocity in single individual water conservancy diversion perforation 1113 reduce, from the outflow of each water conservancy diversion perforation 1113
Blood contacted with oxygen plying membrane structure with easing up.The middle toroidal membrane 111a of right present embodiment each water conservancy diversion perforation
1113 be square opening, and such blood comes together in middle toroidal membrane 111a multiple water conservancy diversion perforation 1113, is led for the multiple of square opening
Flow through the available buffer blood of hole 1113.The position for the outer ring dividing plate 111b for going out blood vessel 1121 that corresponding oxygen closes housing 112 is not provided with
Water conservancy diversion perforation 1113, that is, it is neighbouring go out blood vessel 1121 outer ring dividing plate 111b water conservancy diversion perforation 1113 center and go out blood vessel
The beeline at 1121 center is more than 5mm, avoids blood directly from close to the stream of multiple water conservancy diversion perforation 1113 for going out blood vessel 1121
Go out, blood is flowed out from away from the multiple water conservancy diversion perforation 1113 for going out blood vessel 1121, improve the utilization rate of oxygen plying membrane structure, and
Blood is set uniformly to spread.
Middle toroidal membrane 111a and outer ring the dividing plate 111b of present embodiment inner surface is further provided with spaced more
Individual spiral stream guidance groove (as shown in figure 11), the middle toroidal membrane 111a and outer ring dividing plate 111b difference of multiple water conservancy diversion perforation 1113
In middle toroidal membrane 111a and outer ring dividing plate 111b multiple spiral stream guidance grooves.Each spiral stream guidance grooved ring is around middle ring
It is more than the half-turn of shape dividing plate 111a or outer ring dividing plate 111b inner surface, in other words, one end of each spiral stream guidance groove
Horizontal circumferential length to its other end is more than middle toroidal membrane 111a or outer ring dividing plate 111b semicircle girth, each spiral shell
Revolve middle toroidal membrane 111a or outer ring dividing plate of the vertical range between half of end With its other end of guiding gutter
111b height and 2/3rds middle toroidal membrane 111a or outer ring dividing plate 111b height.
Figure 11 is referred to, it is the profile of the core shaft structure 110 of the embodiment of the application the 7th；As illustrated, this reality
Applying the inner surface of the ring diversion plate 1102 of the core shaft structure 110 of mode has spaced multiple spiral stream guidance grooves 11022,
Multiple water conservancy diversion perforation 11021 are between multiple spiral stream guidance grooves 11022, and each spiral stream guidance groove 11022 is around annular water conservancy diversion
It is more than the half-turn of the inner surface of plate 1102, in other words, the level of one end of each spiral stream guidance groove 11022 to its other end
Circumferential length is more than the semicircle girth of ring diversion plate 1102, end With its other end of each spiral stream guidance groove 11022
Height and the height of 2/3rds ring diversion plate 1102 of the vertical range between the ring diversion plate 1102 of half.So
The first end 1101a of mandrel body 1101 has water conservancy diversion cambered surface 11011, and one end connection of each spiral stream guidance groove 11022 is led
Cambered surface 11011 is flowed, in other words, multiple spiral stream guidance grooves 11022 are located at the first end 1101a of mandrel body 1101 side,
And the second end 1101b of corresponding mandrel body 1101.The water conservancy diversion cambered surface 11011 of mandrel body 1101 can buffer the flow velocity of blood, and
Guiding blood is swimmingly flowed in blood channel, and blood will not accumulate the first end 1101a in mandrel body 1101.Right multiple spirals
Guiding gutter 11022 is directly connected to water conservancy diversion cambered surface 11011, and water conservancy diversion cambered surface 11011 can directly guide blood to multiple spiral stream guidance grooves
11022, blood quickly fills up multiple spiral stream guidance grooves 11022, and multiple spiral stream guidance grooves 11022 guide blood shunts and from ring
The outflow of multiple water conservancy diversion perforation 11021 of shape deflector 1102, multiple water conservancy diversion perforation 11021 of right ring diversion plate 1102 can be uniform
Ground by blood shunt, increase blood and the contact area and diffusion area of alternating temperature cortina structure, increases alternating temperature cortina structure again
Utilization rate.
Figure 12 is referred to, it is the schematic diagram of the cortina structure 13 of the embodiment of the application the 8th；As illustrated, this implementation
The cortina structure 13 of mode can be applied to the alternating temperature cortina structure and oxygen plying membrane structure of above-mentioned embodiment, and it is included in multilayer
Hollow fiber layer 131, each layer of doughnut layer 131 have multiple hollow fiber conduits 1311, and multiple hollow fiber conduits 1311 are relative
In the angle of vertical plane one, the incline direction of multiple hollow fiber conduits 1311 of each layer of doughnut layer 131 with it is adjacent
The incline direction of multiple hollow fiber conduits 1311 of doughnut layer 131 is different, in other words, wherein one layer of doughnut layer
Multiple hollow fiber conduits 1311 of 131 multiple hollow fiber conduits 1311 and another layer of doughnut layer 131 intersect, often
The hollow fiber conduit 1311 of one layer of doughnut layer 131 and the angle of vertical plane are 15 degree.Each layer of doughnut layer 131
Hollow fiber conduit 1311 section for ellipse, can so reduce blood priming amount.When blood flows into cortina structure 13
During 131, two adjacent doughnut layer, blood can be split into thinner blood film, increase the contact area of blood and oxygen,
Lift the oxygenation efficiency of blood and oxygen.
The ring diversion plate of above-mentioned embodiment, toroidal membrane, water conservancy diversion perforation, the blood of middle toroidal membrane and outer ring dividing plate
The quantity of liquid port or spiral stream guidance groove is one.In addition, the center of the water conservancy diversion perforation adjacent to the middle toroidal membrane 111 for going out blood vessel
The beeline at the center with going out blood vessel is more than 5mm.
In summary, the application provides a kind of spiral stream guidance integrated form membrane oxygenator, and core shaft structure has annular water conservancy diversion
Plate, ring diversion plate guides blood flow by the flow-guiding structure with water conservancy diversion perforation and/or spiral stream guidance groove, and blood is made
Shunting, increase the diffusion area of blood, increase blood and the contact area of cortina structure, effectively lift the utilization of cortina structure
Rate, while lift the oxygenation efficiency of spiral stream guidance integrated form membrane oxygenator.The spiral stream guidance integrated form membrane oxygenation of the application
At least one toroidal membrane can be set in device, and toroidal membrane can support spiral stream guidance integrated form membrane oxygenator, while have thereon
Water conservancy diversion is perforated and/or the flow-guiding structure of spiral stream guidance groove, has identical effect with the flow-guiding structure of ring diversion plate.The application
Cortina structure adjacent two layer doughnut layer spacing it is small, blood can be shunted again, forms blood relatively thin
Blood film, the oxygenation efficiency of blood and oxygen is allowed to be lifted.The section of the hollow fiber conduit of each layer of doughnut layer is circular, side
Shape or ellipse, it can so reduce the priming volume of blood.
The upper only presently filed embodiment, is not limited to the application.For those skilled in the art
For, the application can have various modifications and variations.All any modifications made in spirit herein and principle, it is equal
Replace, improve etc., it all should be included within the scope of claims hereof.
Claims (13)
- A kind of 1. spiral stream guidance integrated form membrane oxygenator, it is characterised in that including：Lower cover, it has escape pipe；Oxygen conjunction portion, it is arranged at the lower cover, and closes housing including core shaft structure, oxygen and be arranged at the core shaft structure and oxygen and close Oxygen plying membrane structure between housing, the oxygen, which closes housing, has a blood vessel, it is described go out blood vessel close to the lower cover；AndUpper lid, it is arranged at the oxygen conjunction portion, and has into blood vessel and oxygen feeding tube, the oxygen feeding tube and escape pipe and connect the core Axle construction and oxygen close the space between housing；Wherein described core shaft structure includes mandrel body and ring diversion plate, and the mandrel body has first end and connection described the The second end of one end, has blood channel between the first end and upper lid, the ring diversion plate is sheathed on the core There is at least one water conservancy diversion to perforate for axis body, the ring diversion plate, at least one water conservancy diversion perforation distributions of the ring diversion plate In on the ring diversion plate.
- 2. spiral stream guidance integrated form membrane oxygenator according to claim 1, it is characterised in that the ring diversion plate At least one water conservancy diversion perforation includes at least one first water conservancy diversion perforation and the perforation of at least one second water conservancy diversion, the ring diversion plate The perforation of at least one first water conservancy diversion close to the lower cover, at least one second water conservancy diversion perforation of the ring diversion plate is located at institute The top of at least one first water conservancy diversion perforation of ring diversion plate is stated, and close to the upper lid, the ring diversion plate is at least The aperture of one the second water conservancy diversion perforation is more than the aperture that at least one first water conservancy diversion of the ring diversion plate is perforated.
- 3. spiral stream guidance integrated form membrane oxygenator according to claim 1, it is characterised in that the ring diversion plate is also Including at least one spiral stream guidance groove, at least one spiral stream guidance groove of the ring diversion plate is arranged at the ring diversion plate Inner surface, the ring diversion plate at least one water conservancy diversion perforation positioned at the ring diversion plate at least one spiral stream guidance In groove, at least one spiral stream guidance groove of the ring diversion plate corresponds to the second end of the mandrel body, its one end connection institute State the first end of mandrel body.
- 4. spiral stream guidance integrated form membrane oxygenator according to claim 1, it is characterised in that the first of the mandrel body End has water conservancy diversion cambered surface.
- 5. spiral stream guidance integrated form membrane oxygenator according to claim 1, it is characterised in that further include at least one ring Shape dividing plate, at least one toroidal membrane are arranged between core shaft structure and oxygen the conjunction housing, and the lower cover has water inlet pipe, The upper lid has outlet pipe, and toroidal membrane and the mandrel into the core shaft structure are leaned in water inlet pipe and the outlet pipe connection Interstructural space；Oxygen feeding tube and the escape pipe connection is leaned on between the toroidal membrane of the core shaft structure and oxygen conjunction housing Space；Alternating temperature cortina structure is provided between the toroidal membrane and the core shaft structure of the core shaft structure, close to the core The toroidal membrane of axle construction and the oxygen are provided with oxygen plying membrane structure between closing housing.
- 6. spiral stream guidance integrated form membrane oxygenator according to claim 5, it is characterised in that the alternating temperature cortina structure And oxygen plying membrane structure includes multilayer hollow fiber layer respectively, each layer of doughnut layer has multiple hollow fiber conduits, each The section of individual hollow fiber conduit is circular, square or oval.
- 7. the spiral stream guidance integrated form membrane oxygenator according to claim 5 or 6, it is characterised in that each annular every There is plate at least one water conservancy diversion to perforate, at least one water conservancy diversion perforation distributions of each toroidal membrane in corresponding annular every Plate.
- 8. spiral stream guidance integrated form membrane oxygenator according to claim 7, it is characterised in that it is described each annular every Plate also includes at least one spiral stream guidance groove, and at least one spiral stream guidance groove of each toroidal membrane is arranged at corresponding ring The inner surface of shape dividing plate, at least one water conservancy diversion perforation of each toroidal membrane are located at the corresponding toroidal membrane extremely In a few spiral stream guidance groove.
- 9. the spiral stream guidance integrated form membrane oxygenator according to claim 5 or 6, it is characterised in that described at least one Toroidal membrane includes middle toroidal membrane and outer ring dividing plate, and the outer ring dividing plate is arranged at the outside of the middle toroidal membrane, The outer ring dividing plate closes housing adjacent to the oxygen, and the middle toroidal membrane and outer ring dividing plate have at least one water conservancy diversion respectively Perforation, at least one water conservancy diversion perforation distributions of the middle toroidal membrane are in the middle toroidal membrane, and the outer ring dividing plate is extremely Few water conservancy diversion perforation distributions are in the outer ring dividing plate.
- 10. spiral stream guidance integrated form membrane oxygenator according to claim 9, it is characterised in that the outer ring dividing plate Surface be provided with filter for removing blood particle and gas microembolus.
- 11. spiral stream guidance integrated form membrane oxygenator according to claim 9, it is characterised in that the middle toroidal membrane And outer ring dividing plate respectively further comprises at least one spiral stream guidance groove, between at least one spiral stream guidance groove of the middle toroidal membrane Every the inner surface for being arranged at the middle toroidal membrane, at least one spiral stream guidance groove of the outer ring dividing plate is arranged at intervals at institute The inner surface of outer ring dividing plate is stated, at least one water conservancy diversion perforation of the middle toroidal membrane and outer ring dividing plate is respectively positioned at described In at least one spiral stream guidance groove of middle toroidal membrane and outer ring dividing plate.
- 12. spiral stream guidance integrated form membrane oxygenator according to claim 9, it is characterised in that go out blood vessel described in neighbouring The middle toroidal membrane and/or the outer ring dividing plate at least one water conservancy diversion perforation center with it is described go out blood vessel center Beeline be more than 5mm.
- 13. the spiral stream guidance integrated form membrane oxygenator according to claim 5 or 6, it is characterised in that each annular every At least one blood port and at least one spiral stream guidance groove of plate including annular arrangement, close to the core shaft structure annular every At least one blood port of plate is arranged at correspondingly close to the lower cover, at least one spiral stream guidance groove of each toroidal membrane Toroidal membrane outer surface, and positioned at least one blood port side.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310546603.0A CN116328070A (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
| CN201710817792.5A CN107362399B (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710817792.5A CN107362399B (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310546603.0A Division CN116328070A (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
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| Publication Number | Publication Date |
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| CN107362399A true CN107362399A (en) | 2017-11-21 |
| CN107362399B CN107362399B (en) | 2023-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202310546603.0A Pending CN116328070A (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
| CN201710817792.5A Active CN107362399B (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202310546603.0A Pending CN116328070A (en) | 2017-09-12 | 2017-09-12 | Spiral diversion integrated film type oxygenator |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110575579A (en) * | 2019-09-23 | 2019-12-17 | 中国科学技术大学 | Dialysis-enhanced hemodialyzer capable of improving blood flow |
| CN111037853A (en) * | 2019-12-27 | 2020-04-21 | 东莞科威医疗器械有限公司 | Injection molding mold for spiral flow guide inner core of oxygenator |
| CN111701103A (en) * | 2020-06-29 | 2020-09-25 | 广东省心血管病研究所 | Pump-free artificial membrane lung for ECMO |
| CN111744065A (en) * | 2020-06-29 | 2020-10-09 | 东莞科威医疗器械有限公司 | Oxycoated silk membrane, oxygenating part and oxygenator for ECMO |
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| US5632894A (en) * | 1994-06-24 | 1997-05-27 | Gish Biomedical, Inc. | Arterial blood filter with upwardly inclining delivery inlet conduit |
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| CN110575579A (en) * | 2019-09-23 | 2019-12-17 | 中国科学技术大学 | Dialysis-enhanced hemodialyzer capable of improving blood flow |
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| CN111701103A (en) * | 2020-06-29 | 2020-09-25 | 广东省心血管病研究所 | Pump-free artificial membrane lung for ECMO |
| CN111744065A (en) * | 2020-06-29 | 2020-10-09 | 东莞科威医疗器械有限公司 | Oxycoated silk membrane, oxygenating part and oxygenator for ECMO |
| CN111701103B (en) * | 2020-06-29 | 2023-03-03 | 广东省心血管病研究所 | Pump-free artificial membrane lung for ECMO |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116328070A (en) | 2023-06-27 |
| CN107362399B (en) | 2023-06-13 |
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