CN116327443A - Stent and valve prosthesis - Google Patents

Abstract

The invention relates to a stent and a valve prosthesis, which comprises at least two first wave rings and second wave rings, wherein the first wave rings are provided with a plurality of first wave crests and a plurality of first wave troughs which are circumferentially arranged at intervals, a first oblique connecting rod is connected between the circumferentially adjacent first wave crests and the first wave troughs, at least two first wave rings are axially connected to form a first grid structure, the second wave rings are provided with a plurality of second wave crests and a plurality of second wave troughs which are circumferentially arranged at intervals, a second oblique connecting rod is connected between the circumferentially adjacent second wave crests and the second wave troughs, the number of the second wave crests of the second wave rings is larger than that of the first wave troughs of the first wave rings, one part of the second wave crests of the second wave rings at the most far end are connected with the first wave troughs of the first wave rings at the most far end, and the other part of the second wave crests of the second wave rings are in a naked state. In the stent and the valve prosthesis, the peak of the bare end is easy to slightly evert, and the anchoring performance can be effectively improved after the stent is implanted into a lesion position, so that the stent is prevented from moving or slipping at the lesion position.

Description

Stent and valve prosthesis

Technical Field

The invention relates to the technical field of medical equipment, in particular to a bracket and a valve prosthesis.

Background

Four valves including an aortic valve, a pulmonary valve, a mitral valve and a tricuspid valve are arranged in the heart of a person, and all of the valves play a role of a one-way valve in the heart, and in the blood circulation process, the heart valve also has rhythmic opening and closing along with rhythmic contraction and relaxation of the heart, so that blood smoothly passes through a valve orifice and is prevented from flowing back, and the blood flows circularly in a certain direction in the body to maintain the normal function of a circulatory system. When heart valves are inflamed, structural damage, fibrosis, adhesion, shortening, myxoma-like degeneration, ischemic necrosis, calcareous precipitation, congenital developmental deformity, etc. can cause valve lesions, influence normal blood circulation, and are medically called heart valve diseases. In elderly people over 65 years old, aortic Stenosis (AS) due to aortic valve degeneration occurs at 10%, with the most common type being calcified aortic stenosis (calcific aortic stenosis, CAS).

The heart valve interventional operation is a medical technology which is rapidly developed in recent years, the principle is that a valve prosthesis is implanted into a primary valve position through a cardiac apex or a blood vessel in a micro-wound mode and replaced, and finally the purpose of treating a patient is achieved. Transcatheter aortic valve implantation (transcatheter aortic valve implantation, TAVI) is a class of heart valve interventional procedures for aortic valve diseases, which are primarily used to treat aortic valve stenosis, aortic valve insufficiency, and valvular heart disease.

Clinical researches show that the release stability of the valve prosthesis is also affected by different calcification degrees of the lesion native valve, the existing valve prosthesis is easy to play or slip in the release process after being implanted to the lesion position, the positioning effect is poor, and the anchoring failure of the valve prosthesis at the lesion position is easy to be caused.

Disclosure of Invention

Based on the above, it is necessary to provide a stent and a valve prosthesis aiming at the problem that the existing valve prosthesis has poor positioning effect in the process of releasing a lesion position.

The invention provides a stent for interventional therapy, the stent comprising:

the first wave rings are provided with a plurality of first wave crests and a plurality of first wave troughs which are circumferentially arranged at intervals, first oblique connecting rods are connected between the circumferentially adjacent first wave crests and the circumferentially adjacent first wave troughs, and the at least two first wave rings are axially connected to form a first grid structure;

the second wave ring is provided with a plurality of second wave crests and a plurality of second wave troughs which are circumferentially arranged at intervals, a second oblique connecting rod is connected between the second wave crests and the second wave troughs which are circumferentially adjacent, the number of the second wave crests of the second wave ring is larger than that of the first wave troughs of the first wave ring, one part of the second wave crests of the farthest end is connected with the first wave troughs of the first wave ring of the nearest end, and the other part of the second wave crests of the second wave ring are in a naked state.

In one embodiment, the number of the first wave troughs of the first wave ring is N, the number of the second wave peaks of the second wave ring is 2N, the N second wave peaks of the second wave ring are connected with the N first wave troughs of the first wave ring, and the other N second wave peaks of the second wave ring are in a bare state.

In one embodiment, the N second wave crests connected to the first wave ring and the N second wave crests in the exposed state are sequentially arranged at intervals along the circumferential direction.

In one embodiment, the first wave crests of the first wave rings which are axially adjacent are connected through a first axial connecting rod; and/or the first wave troughs of the first wave rings which are axially adjacent are connected through a second axial connecting rod.

In one embodiment, the first axial link and/or the second axial link are provided with a fixation portion thereon, the fixation portion being configured for fixing a valve.

In one embodiment, the maximum width of the axial cross-section of the second axial link is greater than the maximum width of the axial cross-section of the first axial link.

In one embodiment, at least a part of the axial section of the inner ring space surrounded by the plurality of first wave rings is an outflow section, at least a part of the axial section of the inner ring space surrounded by the plurality of second wave rings is an inflow section, and the axial length of the outflow section is smaller than the axial length of the inflow section.

In one embodiment, the first oblique connecting rod is any one or any combination of a straight rod, a curve rod and a wave rod; and/or the second oblique connecting rod is any one or any combination of a straight rod, a curve rod and a wave rod.

In one embodiment, two circumferentially adjacent first oblique connecting rods in the first wave ring are symmetrical relative to a first crest or a first trough between the two; and/or two circumferentially adjacent second oblique connecting rods in the second wave ring are symmetrical relative to a second crest or a second trough between the two.

In one embodiment, at least two second wave rings are connected along the axial direction to form a second grid structure.

In one embodiment, the second peaks and second troughs of axially adjacent second wave rings are directly connected; or, the second wave crest and the second wave trough of the second wave ring which are axially adjacent are indirectly connected through a third axial connecting rod.

In one embodiment, the second lattice structure is connected with an extending lattice structure along the axial direction.

The present invention also provides a valve prosthesis comprising:

the support;

at least two valves, at least two valves can be relatively arranged in the bracket in an opening and closing way.

In the stent and the valve prosthesis, the second wave crest which is not used for being connected with the first wave trough on the second wave ring can be in a naked state to form a naked end wave crest, and the naked end wave crest has smaller radial rigidity relative to other structures on the stent because of no connection relation with other structures on the stent, so that corresponding slight eversion or slight indent is formed relative to the stent when external force is applied, for example, the naked end wave crest has preferential expansion capability compared with other sections on the stent under the action of a balloon, slight eversion can be formed, after the naked end wave crest is implanted to a lesion position, if the naked end wave crest everts relative to the stent, other positions on the stent have corresponding indent forms, the anchoring performance can be effectively improved, the stent is prevented from moving or slipping at the lesion position, the positioning effect is improved, and the anchoring failure rate is reduced.

Drawings

FIG. 1 is a perspective view of a stent for interventional therapy provided in one embodiment of the present invention;

FIG. 2 is a schematic view of a partial structure of the stent for interventional therapy shown in FIG. 1;

FIG. 3 is a perspective view of a stent for interventional therapy provided in another embodiment of the present invention;

fig. 4 is a schematic diagram of the stress principle of the parallelogram grid structure according to an embodiment of the present invention.

Reference numerals:

001. an outflow section; 002. an inflow section; 003. an axis;

100. a first wave ring; 200. a second wave ring; 300. a first lattice structure; 400. a second lattice structure;

110. a first peak; 120. a first trough; 130. a first diagonal connecting rod; 140. a first axial link; 150. a second axial link; 160. a fixing part;

210. a second peak; 220. a second trough; 230. a second diagonal connecting rod; 240. and a third axial link.

Detailed Description

In order that the above objects, features and advantages of the invention will be readily understood, a more particular description of the invention will be rendered by reference to the appended drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may be embodied in many other forms than described herein and similarly modified by those skilled in the art without departing from the spirit of the invention, whereby the invention is not limited to the specific embodiments disclosed below.

In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.

In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.

In the present invention, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.

It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.

In this context, "proximal", "lower" or "lower" and "distal", "upper" or "upper" are in reference to the direction of flow of heart blood through the valve holder, and "proximal", "lower" or "lower" and "distal", "upper" or "upper" are not limiting, but "proximal", "lower" or "lower" generally refer to the end proximal to the flow of blood into the valve holder, and "distal", "upper" or "upper" generally refer to the end proximal to the flow of blood out of the valve holder.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

Referring to fig. 1 to 3, an embodiment of the present invention provides a stent for interventional therapy, where the stent includes at least two first wave rings 100 and at least one second wave ring 200, as shown in fig. 1, the stent has an axis 003, a direction of the axis 003 is expressed as an axial direction of the stent, a direction around the axis 003 on the stent is expressed as a circumferential direction of the stent, the first wave rings 100 have a plurality of first wave peaks 110 and a plurality of first wave troughs 120 arranged at intervals in a circumferential direction, first oblique connecting rods 130 are connected between the circumferentially adjacent first wave peaks 110 and first wave troughs 120, at least two first wave rings 100 are connected in an axial direction to form a first grid structure 300, the second wave rings 200 have a plurality of second wave peaks 210 and a plurality of second wave troughs 220 arranged at intervals in a circumferential direction, second oblique connecting rods 230 are connected between the circumferentially adjacent second wave peaks 210 and second wave troughs 220, a number of second wave peaks 210 of the second wave rings 200 is greater than a number of first wave peaks 210 of the first wave rings 100, and a second wave ring 200 is in a state that a second wave ring with a second wave peak 200 at a second wave peak end closest to the first wave ring 100 is connected to the second wave ring.

It should be noted that, the most distal end represents the most distal position of the distal end of the stent, and the most proximal end represents the most proximal position of the proximal end of the stent, that is, when the second wave ring 200 is one, the second wave ring 200 is the second wave ring 200 axially connected to the first wave ring 100, and when the second wave ring 200 is a plurality of second wave rings, the second wave ring 200 located at the most distal end of all the second wave rings 200 and closest to the first wave ring 100 is the second wave ring 200 axially connected to the first wave ring 100. The bare state refers to a state in which the unconnected bare structure is located, and the bare state may be configured as a bare end or a bare area, for example, in the above embodiment, a portion of the second peaks 210 connected to the first valleys 120 is not the bare state, and another portion of the second peaks 210 not connected to the first valleys is the bare state.

The first lattice structure 300 formed by the first wave rings 100 can be located at the distal end of the whole stent, and after at least two first wave rings 100 are axially connected and form the first lattice structure 300, a certain supporting strength can be formed among the plurality of first wave rings 100 by using the first lattice structure 300, so that the stent is ensured to have the capability of expanding a valve under the condition of calcification to a certain extent. Therefore, the second wave ring 200 located at the proximal end of the first wave ring 100 is located at the distal end of the whole stent, and since the number of the second wave peaks 210 of the second wave ring 200 is greater than the number of the first wave troughs 120 of the first wave ring 100, even if all the first wave troughs 120 in the most proximal first wave ring 100 are connected to the second wave peaks 210 of the most distal second wave ring 200, the second wave peaks 210 in the second wave ring 200 are free, so that the second wave peaks 210 on the second wave ring 200 which are not connected to the first wave troughs 120 are exposed, wherein a part of the second wave peaks 210 connected to the first wave troughs 120 are not exposed, and another part of the second wave peaks 210 which are not connected are exposed, which may be called as bare-end wave peaks.

The bare-end peak has smaller radial rigidity relative to other structures on the bracket because the bare-end peak has no connection relation with other structures on the bracket, and is easier to form corresponding slight eversion or slight indent relative to the bracket when being subjected to external force, for example, the bare-end peak has preferential expansion capability compared with other sections on the bracket under the action of a balloon, and can form slight eversion, after being implanted to a lesion position, if the bare-end peak everts relative to the bracket, other positions on the bracket can have corresponding indent forms, which can effectively improve the anchoring performance, prevent the bracket from jumping or slipping at the lesion position, improve the positioning effect and reduce the anchoring failure rate, and at the moment, the first wave ring 100 and the second wave ring 200 can be made of plastic materials, such as cobalt-chromium alloy, stainless steel and the like, or can also be made of memory materials, such as nickel-titanium alloy and the like.

When the second wave crests 210 on the second wave ring 200, which are not connected to the first wave troughs 120, are utilized to form bare end wave crests, the number and arrangement of the bare end wave crests may depend on the respective structural forms of the first wave ring 100 and the second wave ring 200 and the specific form of interconnection between the two, wherein the number of bare end wave crests may be at least one, or may be multiple, and when multiple bare end wave crests are formed, the relative positions of the multiple bare end wave crests may be reasonably arranged to improve the anchoring performance, in one embodiment, the number of the first wave troughs 120 of the first wave ring 100 is N, the number of the second wave crests 210 of the second wave ring 200 is 2N, at this time, the number of the first wave troughs 120 and the second wave crests 210 are in a double relationship, at this time, the N second wave crests 210 of the second wave ring 200 are connected to the N first wave troughs 120 of the first wave ring 100, and then the N second wave crests 210 of the second wave ring 200 are in a bare state, so as to form N bare end wave crests.

When the N second wave crests 210 are connected to the N first wave troughs 120, the specific structures of the first wave ring 100 and the second wave ring 200 may be used to connect in a matching manner in the axial direction, for example, several continuous or discontinuous second wave crests 210 in the N second wave rings 200 may be connected to several wave rings in corresponding positions in the first wave ring 100, so that a plurality of continuous or discontinuous connection points are formed between the N second wave crests 210 and the N first wave rings 100, and likewise, the other N second wave crests 210 in the second wave ring 200 may also have several continuous or discontinuous second wave crests 210 to form a bare state, so that a plurality of continuous or discontinuous bare end wave crests are also formed in the N second wave crests 210 in the N bare state, in one embodiment, the N second wave crests 210 in the second wave ring 200 connected to the first wave ring 100 and the N second wave crests 210 in the bare state are arranged at intervals along the circumferential direction, at the moment, and the upper end wave crests and connection points of the second wave rings 200 are alternately arranged at intervals in the circumferential direction, so as to improve the stability of the bracket in the circumferential direction.

When the axially adjacent first wave rings 100 are connected in the axial direction, the first wave rings 100 may be connected in a matching manner in the axial direction according to a specific structure of the first wave rings 100, for example, the first wave crests 110 in the axially adjacent two first wave rings 100 may be connected to the first wave crests 110, the first wave rings 100 may be connected to the first wave rings 100, the first wave crests 110 and the first wave rings 100 may be connected to each other, or even the first wave crests 110 or the first wave rings 100 may be connected to the first oblique connecting rod 130, and a specific connection form is not limited as long as a grid structure can be formed.

In one embodiment, the first peaks 110 of the first wave rings 100 that are axially adjacent may be connected by a first axial link 140, and the first troughs 120 of the first wave rings 100 that are axially adjacent may be connected by a second axial link 150, so that between two first wave rings 100 that are axially adjacent, two first diagonal links 130 thereof may be in a substantially parallel state, or a standard parallel state, while the first axial link 140 and the second axial link 150 may also be in a substantially parallel state, or a standard parallel state, and thus may be formed substantially as a parallelogram, or directly constitute a standard parallelogram, so that the parallelogram may be formed as a basic structure (or a unit structure) of the first lattice structure 300, and a plurality of parallelograms may be formed into the first lattice structure 300, for example, a plurality of parallelograms circumferentially surrounding a circumference of a bracket may be formed into the first lattice structure 300.

It is found that, by taking a parallelogram as the basic structure of the first lattice structure 300, the lattice stiffness can be improved to a certain extent, assuming that the heights of the brackets are fixed, the heights of the first diagonal connecting rods in the first wave ring 100 or the second diagonal connecting rods in the second wave ring 200 are also determined immediately, as shown in fig. 4, the heights of the diagonal connecting rods in the lattice structure formed by the parallelogram are the same as those of the diagonal connecting rods in the lattice structure formed by the rhombus, assuming that the brackets are anchored in tissues, the extrusion force of the tissues is F0, comparing the parallelogram with the prisms, when acting on the brackets with the same acting force F0, the diagonal connecting rods in the rhombus are subjected to the retractive force f2=f0=sinb, and the angle a > b, and then F1> F2, thereby proving that the diagonal connecting rods in the lattice structure formed by the rhombus are more easily compressed, whereas the diagonal connecting rods in the lattice structure formed by the rhombus are more easily compressed and not easily compressed.

Clinical researches show that the release stability of the valve prosthesis can be affected by different calcification degrees of the lesion native valve, the valve prosthesis can form a conical mouth at the inflow section 002 of the stent in the release process, when the calcification degree of the lesion part is light and the fibrosis degree of the valve is heavy, the stent is not easy to form anchoring immediately after contacting the valve annulus, the slipping of the stent in the release process can be caused, the positioning effect is poor, and if the stiffness of the outflow section 001 of the stent is small, the valve prosthesis can easily play or slip. Therefore, according to the above-mentioned conclusion, the rigidity of the outflow section 001 on the stent can be improved and the anchoring effect can be improved by forming the first lattice structure 300 based on the parallelogram by arranging the first wave ring 100 at the distal end of the stent and enclosing the outflow section 001 at the distal end position of the stent by the first lattice structure 300.

In addition, the outflow section 001 of the stent has higher rigidity, so that the valve orifice can keep better roundness, the valve orifice can be relatively expanded to be larger, the area of the valve orifice is ensured, the hydrodynamic performance is improved, the area of the valve orifice can be ensured to reach the use requirement even in the state that the valve annulus is not fully expanded, the valve can be expanded even if the valve is sutured at the furthest end of the stent based on the higher rigidity of the first grid structure 300, the valve prosthesis can be ensured to have the valve expanding capability even in the severely calcified lesion position, meanwhile, the grid structure taking the parallelogram as the basic structure has larger compression and holding elongation compared with the grid structure taking the diamond as the basic structure, so that the valve is pulled to be axially distributed in the compression and holding process, on one hand, the risk of the membrane clamping caused by valve accumulation can be reduced, and on the other hand, the axial distribution of the valve can further reduce the outline size after the compression and the valve can be placed into a finer blood vessel.

The stent is used as a valve assembly base, the valve can be mounted at a proper position according to the structure of the stent, for example, the first axial connecting rod 140 and the second axial connecting rod 150 can be provided with a fixing part 160, and the fixing part 160 is configured to fix the valve, wherein the fixing part 160 can adopt a hole structure, a convex structure, a concave structure and the like which can realize valve fixing, so as to fix the valve through a proper mode such as binding, clamping and the like, and the valve is not limited herein. In one embodiment, the valve may be secured to the first axial link 140 and the stent may share a portion of the pulling deformation under the pulling action of the valve, thereby increasing the life of the valve.

The first axial link 140 or the second axial link 150 may have a cylindrical shape, a prismatic shape, a plate shape, etc., and the maximum width of the axial section of the second axial link 150 may be set to be larger than the maximum width of the axial section of the first axial link 140, for example, when the structures of the first axial link 140 and the second axial link 150 are cylindrical, the maximum width of the axial section of the first axial link 140 or the second axial link 150, that is, the respective diameter sizes, and when the structures of the first axial link 140 and the second axial link 150 are prismatic, the width of the axial section of the first axial link 140 or the second axial link 150 may be formed into a plurality of values according to the difference of the radial directions, and when the maximum vertical is taken as the respective maximum width, the respective maximum widths may be taken similarly when the structures of the first axial link 140 and the second axial link 150 are other structures.

Since the first axial links 140 are connected between the first peaks 110 of the first wave ring 100 and the second axial links 150 are connected between the first valleys 120 of the first wave ring 100, the position of the circumferential second axial links 150 on the stent is more biased in the proximal direction than the first axial links 140 and is within the outflow section 001, and at this time, the maximum width of the axial cross section of the second axial links 150 is greater than the maximum width of the axial cross section of the first axial links 140, i.e., the structural strength of the second axial links 150 can be made greater than the structural strength of the first axial links 140, so that the rigidity of the outflow section 001 on the stent can be increased in a targeted manner.

For the division of the outflow section 001 and the inflow section 002 on the stent, at least a part of the axial section of the inner ring space surrounded by the plurality of the first wave rings 100 may be the outflow section 001, at least a part of the axial section of the inner ring space surrounded by the plurality of the second wave rings 200 may be the inflow section 002, for example, in one embodiment, the stent may be directly divided into two sections in the axial direction, the distal section on the stent may be the outflow section 001, and the proximal section on the stent may be the inflow section 002, and at this time, the axial length of the outflow section 001 may be set smaller than the axial length of the inflow section 002, and the strength of the outflow section 001 may be increased by controlling the outflow section 001 to have a smaller axial length.

In one embodiment, the first diagonal connecting rod 130 is any one or any combination of a straight rod, a curved rod and a wave rod, the second diagonal connecting rod 230 is any one or any combination of a straight rod, a curved rod and a wave rod, two circumferentially adjacent first diagonal connecting rods 130 in the first wave ring 100 are symmetrical with respect to the first crest 110 or the first trough 120 therebetween, and two circumferentially adjacent second diagonal connecting rods 230 in the second wave ring 200 are symmetrical with respect to the second crest 210 or the second trough 220 therebetween.

The first wave ring 100 may be provided with two, and two first wave rings 100 are connected in the axial direction to form the first grid structure 300 and form the outflow section 001 of the support, the second wave ring 200 may be one or more, in one embodiment, at least two second wave rings 200 are connected in the axial direction to form the second grid structure 400, the first grid structure 300 and the second grid structure 400 are located in different sections of the support in the axial direction, and may be used to meet different functional requirements of different sections in the support, for example, at this time, a prismatic or hexagonal structural shape may be used as a basic structure (or a unit structure) of the second grid structure 400, and a plurality of prismatic or a plurality of hexagonal shapes form the second grid structure 400, for example, a plurality of prismatic or a plurality of hexagonal shapes surrounding the circumference of the support form the second grid structure 400, and compared with the first grid structure 300, the second grid structure 400 may have rigidity smaller than the first grid structure 300 through the structural shape setting.

In one embodiment, the second wave crests 210 and the second wave troughs 220 of the second wave ring 200 that are axially adjacent to each other are directly connected, where two adjacent second wave rings 200 may form a prism, and the prism is used as a base structure of the second grid structure 400, or the second wave crests 210 and the second wave troughs 220 of the second wave ring 200 that are axially adjacent to each other are indirectly connected through a third axial connecting rod 240, where the third axial connecting rod 240 may have a cylindrical structure, a prismatic structure, a plate shape, or the like. Two adjacent second wave rings 200 may form a hexagon and use the hexagon as the basic structure of the second grid structure 400, when two adjacent second wave rings 200 are connected by the second wave crest 210 and the second wave trough 220, the second wave trough 220 in the second wave ring 200 far away from the first wave ring 100 can be in a bare state at the proximal end, for example, in the above embodiment, in the second wave ring 200 far away from the first wave ring 100 (such as the nearest second wave ring 200), the second wave crest 210 forms a connection with the first wave ring 100 or other second wave rings 200, thus is not in a bare state, but the second wave trough 220 does not form a connection, thus is in a bare state, thus forms a bare end wave trough, and at least a part of the bare end wave trough is axially opposite to the bare end wave crest, so that the bare end wave crest and the bare end wave trough can be more expanded due to relatively low radial rigidity when the balloon expands, and the inflow section 002 of the stent forms a shape similar to a ") (" shape, "shape is concave in the center, and the stent can expand even when the stent is expanded, the valve is released in an axial direction, and the stability is improved after the stent is released due to a large axial displacement.

In one embodiment, the second grid structure 400 is connected with an extension grid structure along the axial direction, for example, the extension grid structure may be connected at the proximal end of the second grid structure 400, and the extension grid structure may be any grid structure, for example, the extension grid structure may directly adopt the structural shape of the first grid structure 300 or the second grid structure 400, or the extension grid structure may adopt any structural shape such as a prismatic shape, a hexagonal shape, a circular shape, a square shape, or the like, that is, any structural shape such as a prismatic shape, a hexagonal shape, a circular shape, a square shape, or the like, which may be used as a basic structure (or a unit structure) of the extension grid structure, and form the extension grid structure through a plurality of prismatic shapes, a plurality of hexagonal shapes, a plurality of circular shapes, or a plurality of square shapes, for example, a plurality of prismatic shapes, a plurality of hexagonal shapes, a plurality of circles around the circumference of the support frame, or a plurality of square shapes form the extension grid structure, and a person skilled in the art may select a suitable structural shape according to the needs, without limitation. For example, the stent may be formed by connecting a first lattice structure 300, a second lattice structure 400, and the extension lattice structure in the axial direction.

It can be seen that the whole stent can be formed by only three wave rings including the first wave ring 100 and the second wave ring 200, so that the stent can have a smaller axial length (or a smaller height), which can effectively solve the risk of blocking the coronary artery by too high valve height, and can lower the valve height through structural design, thereby improving the coaxiality of the valve prosthesis and the coaxiality with the valve annulus. Moreover, the first mesh structure 300 formed by the first wave ring 100 is more sparse than the second mesh structure 400 formed by the second wave ring 200, and the more sparse first mesh structure 300 can be used as an outflow section 001 to provide a reliable path for the long-term percutaneous coronary intervention.

The number of the first diagonal links 130 in the first wave ring 100 and the second diagonal links 230 in the second wave ring 200 may be set between 6 and 24, for example, the number of the first diagonal links 130 circumferentially provided in each first wave ring 100 is 6, 8, 10, 12, and the number of the second diagonal links 230 circumferentially provided in each second wave ring 200 is 12, 16, 20, 24, and the number is not limited herein. The body profile of the stent may be configured as a cylinder or an hourglass, which would be required by controlling the configuration of the different first wave ring 100 and the different second wave ring 200, without limitation.

The invention also provides a valve prosthesis comprising the stent and at least two valves, wherein the at least two valves are arranged in the stent in a relatively openable and closable manner. Because the specific structure, functional principle and technical effect of the bracket are described in detail above, the description is omitted herein, and any technical content related to the bracket can be referred to in the description above.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims (13)

1. A stent for interventional therapy, the stent comprising:

the first wave rings are provided with a plurality of first wave crests and a plurality of first wave troughs which are circumferentially arranged at intervals, first oblique connecting rods are connected between the circumferentially adjacent first wave crests and the circumferentially adjacent first wave troughs, and the at least two first wave rings are axially connected to form a first grid structure;

the second wave ring is provided with a plurality of second wave crests and a plurality of second wave troughs which are circumferentially arranged at intervals, a second oblique connecting rod is connected between the second wave crests and the second wave troughs which are circumferentially adjacent, the number of the second wave crests of the second wave ring is larger than that of the first wave troughs of the first wave ring, one part of the second wave crests of the farthest end is connected with the first wave troughs of the first wave ring of the nearest end, and the other part of the second wave crests of the second wave ring are in a naked state.

2. The stent of claim 1, wherein the number of first wave ring wave first troughs is N, the number of second wave ring wave second peaks is 2N, the N second wave ring wave second peaks are connected with the first wave ring wave first troughs, and the other N second wave ring wave second peaks are exposed.

3. The stent of claim 2, wherein the N second peaks connected to the first wave ring and the N second peaks in an exposed state are sequentially spaced apart in a circumferential direction.

4. The stent of claim 1, wherein first peaks of axially adjacent first wave rings are connected by a first axial link; and/or the first wave troughs of the first wave rings which are axially adjacent are connected through a second axial connecting rod.

5. The stent of claim 4, wherein the first axial link and/or the second axial link have a securing portion disposed thereon, the securing portion configured for securing a valve.

6. The bracket of claim 4, wherein a maximum width of an axial cross-section of the second axial link is greater than a maximum width of an axial cross-section of the first axial link.

7. The stent of claim 1, wherein at least a portion of the axial sections of the inner ring space surrounded by the plurality of first wave rings are outflow sections and at least a portion of the axial sections of the inner ring space surrounded by the plurality of second wave rings are inflow sections, the axial length of the outflow sections being less than the axial length of the inflow sections.

8. The bracket of claim 1, wherein the first diagonal connecting rod is any one or any combination of a straight rod, a curved rod and a wave rod; and/or the second oblique connecting rod is any one or any combination of a straight rod, a curve rod and a wave rod.

9. The stent of claim 1, wherein two circumferentially adjacent first diagonal links in the first wave ring are symmetrical with respect to a first peak or a first trough therebetween; and/or two circumferentially adjacent second oblique connecting rods in the second wave ring are symmetrical relative to a second crest or a second trough between the two.

10. The stent of any one of claims 1-9, wherein at least two of the second wave rings are connected in an axial direction to form a second lattice structure.

11. The stent of claim 10, wherein the second peaks and second troughs of axially adjacent second wave rings are directly connected; or, the second wave crest and the second wave trough of the second wave ring which are axially adjacent are indirectly connected through a third axial connecting rod.

12. The stent of claim 10, wherein the second lattice structure has an extended lattice structure connected thereto in an axial direction.

13. A valve prosthesis, the valve prosthesis comprising:

the stent of any one of claims 1-12;

at least two valves, at least two valves can be relatively arranged in the bracket in an opening and closing way.

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