CN116322798A - 包含胃泌素释放肽受体拮抗剂的缀合物或其盐及其用途 - Google Patents
包含胃泌素释放肽受体拮抗剂的缀合物或其盐及其用途 Download PDFInfo
- Publication number
- CN116322798A CN116322798A CN202180065166.XA CN202180065166A CN116322798A CN 116322798 A CN116322798 A CN 116322798A CN 202180065166 A CN202180065166 A CN 202180065166A CN 116322798 A CN116322798 A CN 116322798A
- Authority
- CN
- China
- Prior art keywords
- conjugate
- mice
- radionuclide
- salt
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20306109.8A EP3973999A1 (en) | 2020-09-28 | 2020-09-28 | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| EP20306109.8 | 2020-09-28 | ||
| PCT/EP2021/076107 WO2022063850A1 (en) | 2020-09-28 | 2021-09-22 | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116322798A true CN116322798A (zh) | 2023-06-23 |
Family
ID=74180915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180065166.XA Pending CN116322798A (zh) | 2020-09-28 | 2021-09-22 | 包含胃泌素释放肽受体拮抗剂的缀合物或其盐及其用途 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20230372552A1 (https=) |
| EP (2) | EP3973999A1 (https=) |
| JP (1) | JP7824281B2 (https=) |
| KR (1) | KR20230078690A (https=) |
| CN (1) | CN116322798A (https=) |
| AU (1) | AU2021348219A1 (https=) |
| BR (1) | BR112023003690A2 (https=) |
| CA (1) | CA3189680A1 (https=) |
| DK (1) | DK4188457T3 (https=) |
| ES (1) | ES2989009T3 (https=) |
| FI (1) | FI4188457T3 (https=) |
| HR (1) | HRP20241285T1 (https=) |
| HU (1) | HUE068360T2 (https=) |
| IL (1) | IL300486A (https=) |
| LT (1) | LT4188457T (https=) |
| PL (1) | PL4188457T3 (https=) |
| PT (1) | PT4188457T (https=) |
| RS (1) | RS65994B1 (https=) |
| SI (1) | SI4188457T1 (https=) |
| SM (1) | SMT202400392T1 (https=) |
| WO (1) | WO2022063850A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025163083A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965358A (zh) * | 2008-03-07 | 2011-02-02 | 巴塞尔大学医院 | 铃蟾肽类似肽拮抗物缀合物 |
| US20150217006A1 (en) * | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| CN110678227A (zh) * | 2017-01-12 | 2020-01-10 | 雷迪奥梅迪克斯股份有限公司 | 使用与放射性同位素螯合的奥曲肽衍生物治疗过表达生长抑素受体的癌细胞 |
-
2020
- 2020-09-28 EP EP20306109.8A patent/EP3973999A1/en not_active Withdrawn
-
2021
- 2021-09-22 WO PCT/EP2021/076107 patent/WO2022063850A1/en not_active Ceased
- 2021-09-22 EP EP21778502.1A patent/EP4188457B1/en active Active
- 2021-09-22 RS RS20241053A patent/RS65994B1/sr unknown
- 2021-09-22 PL PL21778502.1T patent/PL4188457T3/pl unknown
- 2021-09-22 JP JP2023518426A patent/JP7824281B2/ja active Active
- 2021-09-22 KR KR1020237011366A patent/KR20230078690A/ko active Pending
- 2021-09-22 FI FIEP21778502.1T patent/FI4188457T3/fi active
- 2021-09-22 CA CA3189680A patent/CA3189680A1/en active Pending
- 2021-09-22 PT PT217785021T patent/PT4188457T/pt unknown
- 2021-09-22 SM SM20240392T patent/SMT202400392T1/it unknown
- 2021-09-22 BR BR112023003690A patent/BR112023003690A2/pt unknown
- 2021-09-22 ES ES21778502T patent/ES2989009T3/es active Active
- 2021-09-22 LT LTEPPCT/EP2021/076107T patent/LT4188457T/lt unknown
- 2021-09-22 SI SI202130186T patent/SI4188457T1/sl unknown
- 2021-09-22 HU HUE21778502A patent/HUE068360T2/hu unknown
- 2021-09-22 US US18/246,706 patent/US20230372552A1/en active Pending
- 2021-09-22 IL IL300486A patent/IL300486A/en unknown
- 2021-09-22 AU AU2021348219A patent/AU2021348219A1/en active Pending
- 2021-09-22 HR HRP20241285TT patent/HRP20241285T1/hr unknown
- 2021-09-22 DK DK21778502.1T patent/DK4188457T3/da active
- 2021-09-22 CN CN202180065166.XA patent/CN116322798A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965358A (zh) * | 2008-03-07 | 2011-02-02 | 巴塞尔大学医院 | 铃蟾肽类似肽拮抗物缀合物 |
| US20150217006A1 (en) * | 2014-02-06 | 2015-08-06 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| CN110678227A (zh) * | 2017-01-12 | 2020-01-10 | 雷迪奥梅迪克斯股份有限公司 | 使用与放射性同位素螯合的奥曲肽衍生物治疗过表达生长抑素受体的癌细胞 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7824281B2 (ja) | 2026-03-04 |
| AU2021348219A1 (en) | 2023-03-09 |
| KR20230078690A (ko) | 2023-06-02 |
| SI4188457T1 (sl) | 2025-01-31 |
| LT4188457T (lt) | 2024-12-27 |
| SMT202400392T1 (it) | 2024-11-15 |
| PT4188457T (pt) | 2024-09-10 |
| WO2022063850A1 (en) | 2022-03-31 |
| DK4188457T3 (da) | 2024-08-26 |
| US20230372552A1 (en) | 2023-11-23 |
| FI4188457T3 (fi) | 2024-09-23 |
| HRP20241285T1 (hr) | 2025-01-03 |
| RS65994B1 (sr) | 2024-10-31 |
| PL4188457T3 (pl) | 2025-01-07 |
| EP3973999A1 (en) | 2022-03-30 |
| BR112023003690A2 (pt) | 2023-04-04 |
| ES2989009T3 (es) | 2024-11-25 |
| IL300486A (en) | 2023-04-01 |
| EP4188457A1 (en) | 2023-06-07 |
| HUE068360T2 (hu) | 2024-12-28 |
| JP2023542218A (ja) | 2023-10-05 |
| CA3189680A1 (en) | 2022-03-31 |
| EP4188457B1 (en) | 2024-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Chen et al. | Pharmacokinetics and tumor retention of 125I-labeled RGD peptide are improved by PEGylation | |
| RU2693465C9 (ru) | Антагонисты grpr для обнаружения, диагностики и лечения grpr-позитивного онкологического заболевания | |
| US5804157A (en) | Peptide compositions and method of radiolabeling | |
| KR20140053819A (ko) | 방사선요법용 177루테튬-표지 봄베신 유사체 | |
| TWI893557B (zh) | 一種靶向sstr2的化合物及其製備方法和應用 | |
| JP7824281B2 (ja) | ガストリン放出ペプチド受容体アンタゴニストを含むコンジュゲートまたはその塩およびそれらの使用 | |
| AU2004222531A1 (en) | Radiolabeled conjugates based on substance P and the uses thereof | |
| CA2464002C (en) | Pacap compositions and methods for tumor imaging and therapy | |
| US20240100202A1 (en) | Psma-targeting conjugate and uses thereof | |
| KR101658206B1 (ko) | 전립선암의 진단 및 치료를 위한 가스트린유리펩티드수용체 길항서열 기반의 신규한 봄베신 유도체 화합물 | |
| RU2821944C2 (ru) | Антагонисты grpr для обнаружения, диагностики и лечения grpr-позитивного онкологического заболевания | |
| WO2026058257A1 (en) | Grpr binding peptides | |
| AU2002342104A1 (en) | PACAP compositions and methods for tumor imaging and therapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |