CN116270903A - Yi medicine Jin Lingqing pharyngeal granules and preparation method thereof - Google Patents
Yi medicine Jin Lingqing pharyngeal granules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Yi medicine Jin Lingqing pharyngeal granules and a preparation method thereof, wherein the Yi medicine Jin Lingqing pharyngeal granules comprise the following raw materials in parts by weight: 1.67-25.05 parts of honeysuckle (Yi nationality: also resistant to Yi nationality), 1.11-16.65 parts of pterodontoseisis (Yi nationality: bei Naipa), 1.11-16.65 parts of peppermint (Yi nationality: pacifica) 1.38-26.27 parts of reed rhizome (Yi nationality: suan ruan), 13.72-34.92 parts of red paeony root (Yi nationality: yi QI Po ZU) and 13.72-34.92 parts of figwort. The invention is derived from Yi nationality ancient Fang Jiajian chemical formula, belongs to a medicine for clearing heat, relieving sore throat and resolving phlegm, has the effects of detoxification and relieving sore throat, and has good effect on pharyngitis. The invention is a pure Chinese (Yi-nationality) medicine preparation, can cooperate with antimicrobial, anti-inflammatory and antioxidant effects, effectively improves the decomposition rate of the medicine in vivo, and is easy to absorb; the invention is a Yi nationality medicine conversion product in Sichuan province, has definite curative effect, safety and reliability and is suitable for popularization and application.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to Yi medicine Jin Lingqing pharyngeal granules and a preparation method thereof.
Background
Pharyngitis is very common, has huge medical and social costs, and reportedly shows that: 1) The proportion of patients with chronic pharyngitis in the patients with the clinic of the otorhinolaryngology department in daily visit is close to 1/3; 2) Statistical analysis is performed on 1100 healthy physical examination persons, and the incidence rate of chronic pharyngitis in the result population is as high as 78.65%.
Western medicine antibiotics and the like can easily cause bacteria in human bodies to lose cell walls to form bacteria L-shape, generate drug resistance, and cause repeated attacks and lasting disunion of chronic pharyngitis; and the western medicines are easy to produce allergic reaction and adverse reaction.
Clinical researches show that the medicament for treating the chronic pharyngitis on the market at present has low total effective rate for treating the chronic pharyngitis.
The combined treatment scheme of the traditional Chinese medicine and the western medicine can effectively improve the total effective rate, reduce the pharyngalgia score and reduce the dosage and the treatment course of antibiotics and hormone compared with the single treatment scheme of the western medicine.
The traditional Chinese medicine composition is derived from ancient and proved prescriptions of Yi nationality, and has definite curative effect on pharyngitis based on the basic rules of treatment of the basis and the theory of the upper law of Yi nationality. Therefore, it is necessary to develop a national medicine Chinese medicine (Yi medicine) preparation with high total effective rate specially aiming at acute and chronic pharyngitis.
Disclosure of Invention
In order to solve the problems, the technical scheme of the invention is as follows:
a Yi medicine Jin Lingqing pharyngeal particle, which comprises the following raw materials in parts by weight: 1.67-25.05 parts of honeysuckle (Yi nationality: also resistant to Yi nationality), 1.11-16.65 parts of pterodontoseisis (Yi nationality: bei Naipa), 1.11-16.65 parts of peppermint (Yi nationality: pacifica) 1.38-26.27 parts of reed rhizome (Yi nationality: suan ruyi), 13.72-34.92 parts of red peony (Yi nationality: yi QI Po ZU) and 13.72-34.92 parts of radix scrophulariae.
The invention has the function of treating acute and chronic pharyngitis and has the basis of traditional Chinese medicine pathology and modern pharmacological analysis.
The main components and pharmacological actions of Jin Lingqing pharyngeal granules are as follows:
honeysuckle flower:
latin name: flos Lonicerae
Description of medicinal materials: dried flower buds or first-placed flowers of Lonicera japonica (Lonicera japonica thunder.) of Caprifoliaceae, lonicera praecox (Lonicera hypoglauca Miq.), lonicera confusa DC, and Lonicera maackii (Lonicera dasystyla Red.) are harvested in 1990 edition of pharmacopoeia of the people's republic of China.
Medicinal material nature taste: sweet in flavor and cold in nature.
Pharmacological action: antipyretic, cooling, exciting, reducing blood lipid, resisting fertility, regulating immunity, relieving inflammation, resisting bacteria, viruses, fungi, leptospira, resisting tumor, sensitization, and removing toxic substances
Description of the functions: can clear away heat and toxic materials, cool and dissipate wind-heat.
Functional action: clear away heat and toxic materials.
The medicinal materials enter the meridian: enter lung, heart and stomach meridians.
The main components are as follows: comprises chlorogenic acid, isochlorogenic acid, luteolin, inositol, volatile oil, etc.
Pterodon japonicus:
latin name: herba Laggerae
Description of medicinal materials: dried aerial parts of the Compositae plant, dendranthema indicum Laggera pterodonta (Candolle) Bentham.
Medicinal material nature taste: cool in nature, pungent and bitter in flavor.
Pharmacological action: antibacterial, antiinflammatory, phlegm eliminating, cough relieving, antitumor, malaria treating, antiviral, etc.
Description of the functions: has effects in clearing away heat and toxic materials, relieving cough, and eliminating phlegm.
Functional action: clear away heat and toxic materials.
The medicinal materials enter the meridian: enter lung meridian and stomach meridian.
The main components are as follows: contains flavonoids, terpenes, organic acids, lactones, phenols, reducing sugar, polysaccharide, and oil.
Peppermint:
latin name: herba Menthae
Description of medicinal materials: the dry aerial parts of the Labiatae plant peppermint (Mentha haplocalyx Briq.) are collected in the 1990 edition of the pharmacopoeia of the people's republic of China.
Medicinal material nature taste: pungent in flavor and cool in nature.
Pharmacological action: analgesic, striated muscle relaxing, antihypertensive, peripheral vascular dilating, antitussive, smooth muscle inhibiting, healing, cholagogue, liver protecting, phlegm eliminating, antifertility, antiinflammatory, antiallergic, antihistamine, antibacterial, antiviral, antifungal, intestinal parasite resisting, skin mucosa treating, and insecticidal effects.
Description of the functions: has effects of dispelling pathogenic wind heat, clearing head and eyes, and promoting eruption.
Functional action: dispersing wind-heat, promoting qi circulation, soothing liver, relieving sore throat, promoting eruption, and clearing head and eyes.
The medicinal materials enter the meridian: it enters lung and liver meridians.
The main components are as follows: the essential oil contains menthol and menthone, menthyl acetate, limonene, camphene, isomenthone, pinene, menthenone, resin, small amount of tannins, rosmarinic acid, etc.
Reed rhizome:
latin name: rhizoma Phragmitis
Description of medicinal materials: is rhizome of reed belonging to Gramineae.
Medicinal material nature taste: sweet in flavor and cold in nature.
Pharmacological action: has effects in inhibiting skeletal muscle, relaxing intestinal canal, and enhancing immunity.
Functional action: stopping hiccup, clearing heat, promoting fluid production to quench thirst, promoting diuresis, relieving restlessness and promoting eruption.
The medicinal materials enter the meridian: lung, stomach, bladder meridian.
The main components are as follows: contains abundant vitamins B1, B2, C and proteins 5%, fat 1%, carbohydrate 51%, and asparagine 0.1%. And contains amino acids, fatty acids, sterols, tocopherols, polyphenols such as caffeic acid and gentisic acid. Also contains 2, 5-dimethoxy-p-benzoquinone, p-hydroxybenzaldehyde, syringaldehyde, coniferyl aldehyde, vanillic acid, ferulic acid, p-coumaric acid, dioxane lignin, etc.
Radix paeoniae rubra:
latin name: paeonia anomala L.
Description of medicinal materials: dried root of Paeonia lactiflora (Paeonia lactiflora pall.) and Paeonia lactiflora (Paeonia veitchii Lynch) belonging to Ranunculaceae is collected in 1990 edition of pharmacopoeia of the people's republic of China.
Medicinal material nature taste: bitter and slightly cold.
Pharmacological action: sedative hypnotic, analgesic, coronary vessel dilating, blood pressure lowering, anoxia tolerance improving, blood lipid reducing, atherosclerosis resisting, anticoagulant, antithrombotic, platelet aggregation resisting, digestive juice secretion promoting, liver protecting, antioxidant, lung function improving, antibacterial, antitumor, and antimutagenic effects.
Description of the functions: has the functions of clearing heat, cooling blood and removing blood stasis.
Functional action: promoting blood circulation, removing blood stasis, clearing heat and cooling blood.
The medicinal materials enter the meridian: enter liver meridian.
The main components are as follows: contains paeoniflorin, and further contains paeoniflorin, hydroxy paeoniflorin, and benzoyl paeoniflorin; and benzoic acid and tannins are contained. Paeonia root is reported to contain (Z) - (1S, 5R) -beta-pinen-10 yl beta-hiberoside, paeoniflorin, and the like.
Radix scrophulariae:
latin name: radix Scrophulariae
Description of medicinal materials: the dried root of radix scrophulariae (Scrophularia ningpoensis hemsl.) belonging to Scrophulariaceae is harvested in 1990 edition of pharmacopoeia of the people's republic of China.
Medicinal material nature taste: slightly cold in nature, sweet in taste, bitter and salty.
Pharmacological action: antipyretic, cooling, antihypertensive, coronary vessel dilating, myocardial ischemia resisting, anoxia resisting, blood sugar reducing, antibacterial and antifungal effects.
Description of the functions: has effects of cooling blood, nourishing yin, purging pathogenic fire, and removing toxic substances.
Functional action: resolving hard mass, nourishing yin, lowering fire, clearing heat, cooling blood and detoxicating.
The medicinal materials enter the meridian: it enters lung, stomach and kidney meridians.
The main components are as follows: contains iridoids such as Ha Badai, 8- (o-methyl-p-coumaroyl) -harpagin, asparagine and trace volatile oil, phytosterol, alkaloid, saccharide, fatty acid and carotene.
In conclusion, the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort can synergistically play the comprehensive functions of regulating immunity, resisting viruses and bacteria, protecting lung and liver, resisting inflammation, resisting oxidation, improving microcirculation, relieving cough and reducing sputum, treat both principal and secondary aspect of disease and can be used for treating acute and chronic pharyngitis.
A preparation method of Yi medicine Jin Lingqing pharyngeal granules comprises the following steps:
firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Due to the adoption of the technical scheme, the beneficial effects obtained by the invention are as follows:
the invention belongs to a medicine for clearing heat, relieving sore throat and resolving phlegm, has the effects of ascending the clear and descending the turbid, removing toxin and relieving sore throat, removing blood stasis and dredging collaterals and relieving pain, cooling blood and nourishing yin, and has good effects on pharyngitis excess syndrome and deficiency-excess syndrome. The invention is a pure traditional Chinese medicine preparation, can cooperate with antimicrobial, anti-inflammatory and antioxidant effects, improves local symptoms, reduces drug resistance caused by abuse of antibiotics, and has higher safety; the invention can effectively improve the decomposition rate of the medicine in vivo, is easy to absorb and has high bioavailability; the invention has definite curative effect, safety, reliability and convenient administration, and is worthy of popularization and application. The product belongs to one of the first Yi medicine research and development conversion products of Sichuan province.
Detailed Description
The invention is further illustrated by the following examples. The following examples are illustrative of the invention and are not intended to limit the scope of the invention. The technical means used in the examples are conventional means well known to those skilled in the art unless otherwise indicated.
Example 1
1. Raw material proportioning
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Example 2
1. Raw material proportioning
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Example 3
1. Raw material proportioning
Raw materials | Formula amount (proportion%) |
Honeysuckle | 8.35 |
Herba Clerodendranthi Spicati | 5.55 |
Mint | 5.55 |
Rhizoma Phragmitis | 22.02 |
Radix paeoniae rubra | 29.27 |
Radix scrophulariae | 29.27 |
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Example 4
1. Raw material proportioning
Raw materials | Formula amount (proportion%) |
Honeysuckle | 26.72 |
Herba Clerodendranthi Spicati | 17.76 |
Mint | 17.76 |
Rhizoma Phragmitis | 10.32 |
Radix paeoniae rubra | 13.72 |
Radix scrophulariae | 13.72 |
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Example 5
1. Raw material proportioning
Raw materials | Formula amount (proportion%) |
Honeysuckle | 3.34 |
Herba Clerodendranthi Spicati | 2.22 |
Mint | 2.22 |
Rhizoma Phragmitis | 25.21 |
Radix paeoniae rubra | 33.51 |
Radix scrophulariae | 33.51 |
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
Example 6
1. Raw material proportioning
Raw materials | Formula amount (proportion%) |
Honeysuckle | 1.67 |
Herba Clerodendranthi Spicati | 1.11 |
Mint | 1.11 |
Rhizoma Phragmitis | 26.27 |
Radix paeoniae rubra | 34.92 |
Radix scrophulariae | 34.92 |
2. Product preparation
Firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby. And (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
[ Property ]
The product is brown yellow granule, has fragrant smell, and sweet and slightly bitter taste.
[ identification ]
(1) Taking 0.2g of the product powder, adding 5ml of methanol, standing for 12 hours, filtering, and taking filtrate as a sample solution. And adding methanol into chlorogenic acid reference substance to obtain 1mg solution per 1ml, and taking the chlorogenic acid reference substance solution as reference substance solution. According to a thin layer chromatography (general rule 0502) test, sucking 10-20 mu l of sample solution and 10 mu l of reference substance solution, respectively spotting on the same silica gel H thin layer plate, taking an upper layer solution of butyl acetate-formic acid-water (7:2.5:2.5) as a developing agent, developing, taking out, airing, and putting under an ultraviolet lamp (365 nm) for detection. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the reference sample.
(2) Taking 3g of the product powder, adding 50ml of methanol, heating and refluxing for 30 minutes, filtering, evaporating filtrate to dryness, and adding 2ml of methanol into residues to dissolve the residues to obtain a sample solution. And adding methanol into the oceanic mugwort reference substance to prepare a solution with 1mg per 1ml as a reference substance solution. According to thin layer chromatography (general rule 0502), 5 μl of each of the above two solutions was sucked and spotted on the same silica gel GF254 thin layer plate, and developed with dichloromethane-ethyl formate-acetone (6:0.5:0.3) as developing agent, taken out, dried, and inspected under ultraviolet lamp (254 nm). Spots of the same color appear in the sample chromatogram at positions corresponding to those of the control chromatogram.
(3) Taking 1g of coarse powder of the product, adding 10ml of absolute ethyl alcohol, carrying out ultrasonic treatment for 20 minutes, filtering, and taking filtrate as a sample solution. 1g of peppermint reference medicine is prepared, and a reference medicine solution is prepared by the same method. Taking menthol reference substance, adding absolute ethanol to prepare a solution containing 2mg per 1ml, and taking the solution as reference substance solution. According to a thin layer chromatography (general rule 0502) test, sucking 5-10 μl of each of the above three solutions, respectively spotting on the same silica gel G thin layer plate, spreading with toluene-ethyl acetate (9:1) as developing agent, taking out, air drying, spraying with 40% sulfuric acid ethanol solution of 2% p-dimethylaminobenzaldehyde, heating at 80deg.C until the spots develop clearly, and placing under ultraviolet lamp (365 nm) for inspection. In the sample chromatogram, fluorescent spots with the same color appear at the positions corresponding to the control chromatogram and the control chromatogram.
(4) Taking 1g of the powder (crushed after drying fresh product), adding 10ml of chloroform, carrying out ultrasonic treatment for 20 minutes, and filtering to obtain filtrate as a test solution. And 1g of rhizoma phragmitis reference medicine is prepared into a reference medicine solution by the same method. According to a thin layer chromatography (general rule 0502) test, 10 μl of each of the above two solutions is absorbed and respectively spotted on the same silica gel G thin layer plate, petroleum ether (60-90 ℃) and ethyl formate (15:5) are used as developing agents, and the developing agents are developed, taken out, dried and sprayed with 10% sulfuric acid ethanol solution, heated at 110 ℃ until the spots develop clearly, and then detected under an ultraviolet lamp (365 nm). In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal material.
(5) Taking 0.5g of the product powder, adding 10ml of ethanol, shaking for 5 minutes, filtering, evaporating filtrate to dryness, and adding 2ml of ethanol into residues to dissolve the residues to obtain a test solution. And adding ethanol into paeoniflorin reference substance to obtain a solution containing 2mg per 1ml, and taking the solution as reference substance solution. According to a thin layer chromatography (general rule 0502) test, 4 μl of each of the above two solutions is sucked and respectively spotted on the same silica gel G thin layer plate, chloroform-ethyl acetate-methanol-formic acid (40:5:10:0.2) is used as developing agent, developed, taken out, dried, sprayed with 5% vanillin sulfuric acid solution, and heated until the spots develop clearly. The same blue-violet spots appear on the sample chromatogram at the positions corresponding to the control chromatogram.
(6) Taking 2g of the product powder, adding 25ml of methanol, soaking for 1 hour, carrying out ultrasonic treatment for 30 minutes, filtering, evaporating the filtrate to dryness, adding 25ml of water into the residue to dissolve, carrying out shaking extraction for 2 times with water-saturated n-butanol for 30ml each time, combining n-butanol solutions, evaporating to dryness, and adding 5ml of methanol into the residue to dissolve to obtain a sample solution. 2g of radix scrophulariae is prepared as a control medicinal material, and the control medicinal material solution is prepared by the same method. And adding methanol into the harpagoside reference substance to prepare a solution with 1mg per 1ml serving as a reference substance solution. According to the thin layer chromatography (general rule 0502), 4 μl of each of the above three solutions is sucked and respectively spotted on the same silica gel G thin layer plate, the lower layer solution of chloroform-methanol-water (12:4:1) is used as developing agent, the developing agent is placed into a developing cylinder which is presaturated for 15 minutes, developed, taken out, dried, sprayed with 5% vanillin sulfuric acid solution, and hot air is blown until the spots develop clearly. In the sample chromatogram, spots with the same color appear at the positions corresponding to the control chromatogram and the control chromatogram.
[ MEANS FOR SOLVING ] measurement by high performance liquid chromatography (appendix VI D).
[ heavy metal examination ]
Taking 1g of the product, placing the product in a crucible, slowly burning the product until the product is completely carbonized, cooling the product to room temperature, adding 1ml of sulfuric acid to moisten the product, heating the product at a low temperature until sulfuric acid vapor is removed completely, cooling the product to room temperature, and checking that the product contains no more than twenty parts per million of heavy metals according to law (second method of appendix IX E of Chinese pharmacopoeia 2005 edition).
[ usage and dosage ]
The medicine is taken with boiled water 1 bag at a time and 3 times a day.
The invention is different from western medicine antibiotics, has the effects of clearing heat, relieving sore throat and resolving phlegm, does not generate drug resistance in clinical application, and has obvious advantages of treating acute and chronic pharyngitis, upper respiratory tract infection and bronchopneumonia; the invention is derived from the ancient prescription and proved prescription of Yi medicine for thousands of years, carries out addition, subtraction and chemical combination based on the basic treatment rules of Yi medicine ' cause and root cause control ' and the theory of Yi medicine ' upper method ' for treating pharyngitis, and selects the prescription of the medicine ' pterodontoseisis with characteristics of Yi medicine; the product can comprehensively and particularly and prominently solve the specimen problems of pharyngitis and cough, and has no toxic or side effect; as a Chinese medicine (Yi nationality medicine) preparation, the preparation is a product of the perfect combination of the essence of the national medicine and the modern pharmaceutical industry, has the effects of detoxification, relieving sore throat, removing blood stasis, dredging collaterals, relieving pain, cooling blood and nourishing yin, has good effects on the symptoms of pharyngitis and excessive syndrome and deficiency and excessive inclusion, can cooperate with antimicrobial, anti-inflammatory and antioxidant effects, improves local symptoms and reduces drug resistance caused by abuse of antibiotics. The product belongs to one of the first Yi medicine research and development conversion products of Sichuan province.
Test example 1
200 chronic pharyngitis patients are randomly divided into a treatment group and a control group, wherein 100 patients are treated by taking the medicament of the invention; 100 cases of control groups are treated by western medicines; the treatment course is 7 days. The efficacy evaluation results were as follows:
table 1. Data of curative effect of Yi medicine Jin Lingqing pharyngeal particles on treatment of chronic pharyngitis:
cure rate (%) | Good conversion (%) | Total effective rate (%) | |
Jin Lingqing throat granule | 34 | 64 | 98 |
Antibiotics | 18 | 58 | 76 |
During observation, normal blood, urine and feces are observed, and abnormal changes and toxic and side effects are not found in safety observation of heart, liver, kidney functions and the like.
The results show that the invention has the effects of detoxification, sore throat relieving, stasis dispelling, vein relaxing, pain relieving, blood cooling and yin nourishing, has definite curative effect on chronic pharyngitis, is safe and reliable, is convenient to take, and is worthy of popularization and application.
Although embodiments of the present invention have been disclosed above, it is not limited to the details of the description and the embodiments, which are well suited to various fields of use, additional modifications may be readily made by those skilled in the art without departing from the general concept defined by the claims and their equivalents.
Claims (8)
1. The Yi medicine Jin Lingqing pharyngeal granules are characterized by comprising the following raw materials in parts by weight: 1.67-25.05 parts of honeysuckle (Yi nationality: also resistant to Yi nationality), 1.11-16.65 parts of pterodontoseisis (Yi nationality: bei Naipa), 1.11-16.65 parts of peppermint (Yi nationality: pacifica) 1.38-26.27 parts of reed rhizome (Yi nationality: suan ruyi), 13.72-34.92 parts of red peony (Yi nationality: yi QI Po ZU) and 13.72-34.92 parts of radix scrophulariae.
2. A method for preparing Yi medicine Jin Lingqing pharyngeal granules, which is characterized by comprising the following steps:
firstly, taking honeysuckle, laggera pterodonta, peppermint, reed rhizome, red paeony root and figwort root according to the mass parts, putting the honeysuckle, the laggera pterodonta, the peppermint, the reed rhizome, the red paeony root and the figwort root into a 1 ton extraction tank, adding 10 times of drinking water for the first time, soaking for 30 minutes, starting a reflux device to collect reflux liquid, keeping the liquid level slightly boiling after boiling, starting timing with the reflux of a first drop of reflux liquid, distilling medicinal materials for 30 minutes, and putting the reflux liquid into a closed container for standby; and (5) closing the reflux device for continuous decoction for 30 minutes, and filtering the liquid medicine by a 80-mesh screen for later use.
3. Adding 10 times of drinking water respectively for the second time and the third time, decocting for 60 minutes each time, filtering the decoction by a 80-mesh screen after the decoction is finished, and combining the three filtrates to be concentrated.
4. And thirdly, mixing the extracting solution extracted for three times and the reflux liquid, then sucking the mixture into a single-effect concentrator, controlling the vacuum degree to be- (0.075-0.085 Mpa), concentrating the mixture at the concentration temperature of 45-55 ℃ under reduced pressure, and concentrating the mixture into extractum with the relative density of 1.36-1.39 (50 ℃) for later use.
5. Step four, granulating: the sucrose is crushed by 80 meshes to obtain sucrose powder, 1 part of extract with qualified relative density, 1 part of dextrin and 4 parts of sucrose powder are weighed, the sucrose powder and the dextrin are poured into a groove type mixer and stirred for 3 minutes, the extract and purified water or 75% ethanol are added to prepare a proper soft material, and the soft material is granulated by a 14-mesh nylon net swing granulator.
6. And fifthly, putting the prepared wet particles into a fluidized bed dryer, setting the drying temperature to be 60 ℃ for drying, and taking out of the pot after the moisture of the particles is lower than 2.0%.
7. Step six, the dried granules are finished by a stainless steel screen mesh with 10 meshes and 28 meshes, qualified granules are obtained in the middle of 10 meshes to 28 meshes, and the qualified granules are put into a turnover barrel for standby.
8. And seventhly, subpackaging the qualified particles by using a blank coiled film with the specification of 140mm, wherein the packaging amount is controlled between 9.7 and 10.4g during subpackaging.
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Non-Patent Citations (2)
Title |
---|
侯妍: "中药雾化吸入治疗急慢性咽炎疗效观察", 中国校医, no. 02, 25 April 2001 (2001-04-25), pages 1 - 6 * |
董韶昱, 董彩霞: "金嗓利咽丸治疗慢性咽炎256例", 河南中医, no. 10, 10 October 2005 (2005-10-10), pages 57 * |
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