CN116270297A - 一种含视黄醇的三相组合物以及外用皮肤制剂 - Google Patents
一种含视黄醇的三相组合物以及外用皮肤制剂 Download PDFInfo
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- CN116270297A CN116270297A CN202310254925.8A CN202310254925A CN116270297A CN 116270297 A CN116270297 A CN 116270297A CN 202310254925 A CN202310254925 A CN 202310254925A CN 116270297 A CN116270297 A CN 116270297A
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Abstract
本申请提供了一种含视黄醇的三相组合物和外用皮肤制剂，其包括：油，所述油与聚二甲基硅氧烷不互溶；所述油的密度小于聚二甲基硅氧烷；聚二甲基硅氧烷；水；视黄醇和/或视黄醇衍生物；所述油与聚二甲基硅氧烷的含量比或者，所述聚二甲基硅氧烷与油的含量比不高于60:1。本申请所的组合物能够有效保护视黄醇等油溶性活性物，活性物的活性保存率高。
Description
技术领域
本申请涉及化妆品领域，具体而言，涉及一种含视黄醇的三相组合物以及外用皮肤制剂。
背景技术
视黄醇，又称维生素A，为人体维持正常代谢和机能所必需的脂溶性维生素，由美国科学家Elmer Mc Collum和MArgAret Davis在1912～1914年之间发现。在临床医疗上被用于治疗夜盲症、干眼病、角膜软化症和皮肤粗糙、痤疮、牛皮癣和其他皮肤疾病。在化妆品上具有促进胶原蛋白、抑制金属蛋白酶活性的效果，被广泛应用在抗老产品中。
视黄醇由20碳结构构成的单环二萜类分子、具有一个β-紫罗酮环、一个由四个头尾相连的类异戊二烯单元组成的侧链，结构中的五个共轭双键均为反式构型，视黄醇及其衍生物暴露在空气中或光照下（紫外线下）很容易被氧化和发生异构化，从而产生活性降低、丧失或变色问题，也给其在护肤品应用带来了极大的困难，如何去保持在使用前以及使用途中的视黄醇活性成为了目前化妆品以及医学领域最大的挑战之一。
现有技术中为防止视黄醇及其衍生物被氧化，一般通过脂质体包裹、纯油或表面活性剂分散视黄醇以及真空包装、充氮气等方式去保护视黄醇，但上述方法均各有不足。例如，脂质体包裹制备成本大、工艺繁琐、配方兼容性以及适配性较差等问题；纯油产品的肤感较差，容易造成毛孔堵塞，而表面活性剂分散型视黄醇产品直接用于皮肤，会给皮肤带来很大的负担，如刺激性。
发明内容
本申请要解决的技术问题：
利用油水双层体系搭载视黄醇是已知的。油水双层体系的优势在于工艺简单，产品的稳定高，能够兼容多种包材。油水双层体系的缺陷在于，视黄醇失活一般情况下是由于接触氧化剂并发生反应。在油水双层体系中，尽管油相会将溶于其中的视黄醇与水分隔开，但由于油相本身与水相直接接触，水中的溶解氧仍有较大几率直接接触视黄醇，进而导致视黄醇活性减损，进而导致油水双层体系中视黄醇的活性保留率较差。
解决技术问题所用的技术手段：
发明人经过大量研究，提出一种解决办法，即制备一种由水相、油相（如植物油）和硅油相组成的组合物，其中油相、硅油相和水相自上到下依次分布。视黄醇或其衍生物在加入组合物后会倾向于存在于油相中，同时，不与油相互溶、也不与水相互溶的硅油相起到分隔油相和水相的作用，可以减少油相（含视黄醇或其衍生物）直接接触到水相中的活性氧，甚至摇匀使用后也可以很快分开。现有技术中，普遍认为硅油的隔绝溶解氧的能力较差，并不能有效保护活性物质不受水中溶解氧的影响。但发明人发现，当以硅油作为隔离相（隔离水相和油相）时，能够对视黄醇或其衍生物起到优异的保护作用。
本申请的一个方面，提供了一种组合物，其包括：油，所述油与聚二甲基硅氧烷不互溶；所述油的密度小于聚二甲基硅氧烷；聚二甲基硅氧烷；水；视黄醇和/或视黄醇衍生物；所述油与聚二甲基硅氧烷的含量比或者，所述聚二甲基硅氧烷与油的含量比不高于60:1。
本申请的另一方面，提供了一种组合物，包括：上层，所述上层包括油，所述油中包含视黄醇和/或视黄醇衍生物；中间层，所述中间层为聚二甲基硅氧烷；下层，所述下层为水层；所述上层与中间层的含量比或者，所述中间层与上层的含量比不高于60:1。
本申请的另一方面，提供了一种外用皮肤制剂，其包括前述的任意一种组合物。
有益效果
本申请所提供的技术方案能够有效保护视黄醇等油溶性活性物，活性物的活性保存率高。
本申请所提供的技术方案为多层体系，体系不含表面活性剂，不会因为表面活性剂的加入对皮肤造成额外的刺激。
附图说明
本申请还提供了与本申请所提供的技术方案有关的附图来说明本申请的技术方案。附图及说明的目的仅为更清楚地描述本申请，不应被看作是对本申请要求保护的范围的限定。
图1示出实验组5的料体外观；
图2示出实验组1的料体外观。
实施方式
为使本申请实施例的目的、技术方案和优点更加清楚，下面将对本申请实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例不是全部的实施例。
本申请的一种实施方式中描述的元素和特征可以与一个或更多个其它实施方式中示出的元素和特征相结合。应当注意，为了清楚的目的，说明中省略了与本申请无关的、本领域普通技术人员已知的部件和处理的表示和描述。
定义
在本文中，除非另有说明，用语“％”是指“质量％”。
在本文中，用语“不高于”是指：小于和小于等于。
在本文中，用语“不低于”是指：大于和大于等于。
在本文中，除非另有说明，本文用语“％”均是指基于本申请组合物的总重量而言的。
在本文中，限定的所有范围是指：包括给定范围内的每个特定范围以及给定范围之间的子范围的组合。例如，1～5的范围具体包括1、2、3、4和5，也包括如2～5、3～5、2～3、2～4、1～4等子范围。
在本文中，比率的范围是指：包括给定范围内的每个特定比率以及给定范围之间的子范围的组合。
本申请
本申请的一个方面，提供了一种组合物，其包括：
油，所述油与聚二甲基硅氧烷不互溶；所述油的密度小于聚二甲基硅氧烷；
聚二甲基硅氧烷；
水；
视黄醇和/或视黄醇衍生物；
所述油与聚二甲基硅氧烷的含量比或者，所述聚二甲基硅氧烷与油的含量比不高于60:1。
可选地，所述油包括霍霍巴籽油、海檀木籽油、刺阿干树仁油、葡萄籽油、澳洲坚果籽油、甜肩桃油、向日葵籽油、全缘叶澳洲坚果籽油、鳄梨油、油橄榄果油、牡丹籽油、金盛花油、小麦胚芽油、澳洲蓝柏木油、白池花籽油、伯尔硬胡桃籽油、稻胚芽油、红木籽油、野大豆油、山茶籽油、玻璃苣籽油、印加果籽油、小果咖啡籽油、猴面包树籽油、沙棘果油、白花春黄菊花油、巴巴苏籽油、白兰花油、白叶腊菊花油、白千层油、白兰叶油、彼得松薄子木油、斑点老鹳草油、车前叶蓝蓟籽油、川谷籽油、草棉籽油、大果越桔籽油、川芎油、大裂叶五桤木籽油、稻糠油、滇山茶籽油、地中海柏木油、覆盆子籽油、海棠果籽油、广西沙柑果皮油、红莓苔子籽油、互生叶白千层叶油中的至少一种。
可选地，所述油的含量为0.5～70%。
可选地，所述聚二甲基硅氧烷的含量为0.5～20%。
可选地，所述视黄醇衍生物包括视黄醇棕榈酸酯、视黄醇丙酸酯、羟基频哪酮视黄酸酯、视黄醇视黄酸酯、视黄醇乙酸酯、视黄醇亚油酸酯中的至少一种。
可选地，所述视黄醇或视黄醇衍生物的含量为0.01～5%。
本申请的另一方面，提供了一种组合物，其包括：
上层，所述上层包括油，所述油中包含视黄醇或视黄醇衍生物；
中间层，所述中间层为聚二甲基硅氧烷；
下层，所述下层为水层；
所述上层与中间层的含量比或者，所述中间层与上层的含量比不高于60:1。
可选地，所述油包括霍霍巴籽油、海檀木籽油、刺阿干树仁油、葡萄籽油、澳洲坚果籽油、甜肩桃油、向日葵籽油、全缘叶澳洲坚果籽油、鳄梨油、油橄榄果油、牡丹籽油、金盛花油、小麦胚芽油、澳洲蓝柏木油、白池花籽油、伯尔硬胡桃籽油、稻胚芽油、红木籽油、野大豆油、山茶籽油、玻璃苣籽油、印加果籽油、小果咖啡籽油、猴面包树籽油、沙棘果油、白花春黄菊花油、巴巴苏籽油、白兰花油、白叶腊菊花油、白千层油、白兰叶油、彼得松薄子木油、斑点老鹳草油、车前叶蓝蓟籽油、川谷籽油、草棉籽油、大果越桔籽油、川芎油、大裂叶五桤木籽油、稻糠油、滇山茶籽油、地中海柏木油、覆盆子籽油、海棠果籽油、广西沙柑果皮油、红莓苔子籽油、互生叶白千层叶油中的至少一种。
可选地，所述油的含量为0.5～70%。
可选地，所述聚二甲基硅氧烷的含量为0.5～20%。
可选地，所述视黄醇衍生物包括视黄醇棕榈酸酯、视黄醇丙酸酯、羟基频哪酮视黄酸酯、视黄醇视黄酸酯、视黄醇乙酸酯、视黄醇亚油酸酯中的至少一种。
本申请的另一方面，提供了一种外用皮肤制剂，其包括前述的任意一种组合物。
本申请的组合物
在本申请的组合物中，包括油，所述油与聚二甲基硅氧烷不互溶，所述油的密度小于聚二甲基硅氧烷。
所述油与聚二甲基硅氧烷不互溶是指：所述油与聚二甲基硅氧烷不能形成热力学稳定体系，从而互不相溶，当加入视黄醇和/或视黄醇衍生物后，视黄醇和/或视黄醇衍生物会溶于或者弥散于油中，并与聚二甲基硅氧烷相互分隔。而同时，当所述油的密度小于聚二甲基硅氧烷时，溶解或弥散有油溶性活性物的油相位于聚二甲基硅氧烷相（或称硅油相）的上方。当体系中加入水后，水相位于聚二甲基硅氧烷相（或称硅油相）下方，由此，聚二甲基硅氧烷将油相与水相分隔开。作为优选地，所述油为霍霍巴籽油、海檀木籽油、刺阿干树仁油、葡萄籽油、澳洲坚果籽油、甜肩桃油、向日葵籽油、全缘叶澳洲坚果籽油、鳄梨油、油橄榄果油、牡丹籽油、金盛花油、小麦胚芽油、澳洲蓝柏木油、白池花籽油、伯尔硬胡桃籽油、稻胚芽油、红木籽油、野大豆油、山茶籽油、玻璃苣籽油、印加果籽油、小果咖啡籽油、猴面包树籽油、沙棘果油、白花春黄菊花油、巴巴苏籽油、白兰花油、白叶腊菊花油、白千层油、白兰叶油、彼得松薄子木油、斑点老鹳草油、车前叶蓝蓟籽油、川谷籽油、草棉籽油、大果越桔籽油、川芎油、大裂叶五桤木籽油、稻糠油、滇山茶籽油、地中海柏木油、覆盆子籽油、海棠果籽油、广西沙柑果皮油、红莓苔子籽油、互生叶白千层叶油中的至少一种。作为优选地，所述油的含量为0.5～70%。
在本申请的组合物中，所述聚二甲基硅氧烷仅指硅油，不包括硅油的改性物。作为优选地，所述聚二甲基硅氧烷的含量为0.5～20%。
在本申请的组合物中，视黄醇衍生物具体可举例如视黄醇棕榈酸酯、视黄醇丙酸酯、羟基频哪酮视黄酸酯、视黄醇视黄酸酯、视黄醇乙酸酯、视黄醇亚油酸酯等。作为优选地，所述视黄醇、视黄醇衍生物的含量为0.01～5%。
在本申请的组合物中，所述油与聚二甲基硅氧烷的含量比或者，所述聚二甲基硅氧烷与油的含量比不高于60:1。当油与聚二甲基硅氧烷的含量比超过60:1或者，当聚二甲基硅氧烷与油的含量比超过60:1时，会发生聚二甲基硅氧烷与油互溶的情况。
本申请的外用皮肤制
本发明的外用皮肤制剂还含有通常用作化妆品的成分,例如稳定剂、表面活性剂、润滑剂、缓冲剂、甜味剂和调味剂、粘合剂、脱色剂、抗氧化剂、涂层剂、润湿剂、调味剂剂,着色剂, 包衣剂, 张力剂, 乳化剂, 增稠剂, pH调节剂, 赋形剂, 分散剂, 崩解剂, 保鲜剂, 保鲜剂, 增溶剂, 增溶剂, 油脂, 保湿剂, 紫外线吸收剂, 填充剂, 螯合剂, 防晒剂, 消泡剂、柔软剂、推进剂、酸化剂。
示例性的，如包括：
美白剂
所述美白剂可举例如，曲酸、氢醌、抗坏血酸及其衍生物、熊果苷、鞣花酸、光甘草定、生育酚、阿魏酸、壬二酸、壬二酰二甘氨酸、植物提取物等。
抗氧化剂
所述抗氧化剂可举例如，葡糖基芦丁、焦亚硫酸钠、硫酸钠、神经酰胺、透明质酸、矿物盐、维生素B1、维生素B2、维生素B6、烟酸、泛酸、维生素C及其衍生物、维生素D及其衍生物、维生素E及其衍生物、多肽、多糖、生长因子、二甲氨基乙醇、辅酶Q10、植物提取物、促进HSPs表达的活性组分、激活水通道蛋白的组分等。
具体地，多肽可举例如，具有祛皱抗衰作用的多肽，如三肽-1、乙酰基六肽-8、乙酰基八肽-3、二肽二氨基丁酰苄基酰胺二乙酸盐、β-丙氨酰羟脯氨酰二氨基丁酰苄基酰胺、棕榈酰五肽-4、棕榈酰四肽-7、肌肽、三肽-1铜、棕榈酰三肽-1、棕榈酰三肽-5、棕榈酰寡肽、六肽-9、六肽-11等。具有祛痘修复作用的多肽，如肉豆蔻酰六肽-5、肉豆蔻酰六肽-23、四肽-1、抗菌十五肽、六肽-9、棕榈酰五肽-4等。具有美白祛斑作用的多肽，如九肽-1、四肽-27、十肽-12、六肽-2、肌肽、谷胱甘肽等。具有舒缓抗敏作用的多肽，如棕榈酰三肽-8、乙酰基四肽-15、乙酰基四肽-40、乙酰基二肽-1鲸蜡酯、乙酰基六肽-49等。具有祛除眼袋作用的多肽，如乙酰基四肽-5、棕榈酰四肽-7、二肽-2、棕榈酰三肽-1、棕榈酰五肽-4等。
具体地，植物提取物可举例如，来源于以下植物或其特定部位的提取物：甘菊、常春藤、柠檬、人参、覆盆子、栀子、胡萝卜、橙、桃、菠萝、龙胆、芙蓉花、核桃叶、南瓜、牡丹、藜麦、波尔多叶、田旋花、鼠尾草、石榴、牛至、姜、马郁兰、酸果蔓、葡萄、番茄、姜根、绿茶、红茶、真芦荟、槐树、番木瓜、菠萝、南瓜、番薯、柴胡、纯叶号角树、鸡冠花、积雪草、奎奴亚藜、金黄洋甘菊、苦橙、咖啡、毛喉蕊花、没药、海茴香、丁香、银杏、常春藤、水解藻、玫瑰茄、巴拉圭茶、掌状海带、红莲、瓜拉纳、波尔多树、褐藻、夏枯草、甜扁桃、假叶树、金雀花、西洋接骨木、钝顶螺旋藻、域毛钩藤、马鞭草、梨果仙人掌、白柳、羽扇豆属、黑麦、款冬花、千叶蓍、黑茶镳子籽油、向日葵籽油不皂化物、印度苦楝树、紫萁、面包树、三叶鬼针草、构树、小球藻、美类叶升麻、余甘子、光果甘草、甘草、番红花、冬青、川芎灵芝、川芎、海巴戟、桑、山桑、杏梅、太子参、皱叶酸模、西酸模、倒地铃花/叶/藤、无患子、虎耳草、盔状黄芩、垂盆草、小麦、熊果、南非醉茄、麝香玫瑰、松果菊、聚合草、问荆、金丝桃、含羞草、牛油果、非洲臀果木、马铃薯、迷迭香、矮丛蓝莓、巨藻、红叶金虎尾、洋蓟、草棉、黍稷、黑桑、芝麻、野生大豆、麦芽、亚麻、红三叶草、白羽扇豆、榛子、玉米、山毛榉树芽、新西兰亚麻、锡兰肉桂、糖海带、油橄榄叶、榆绣线菊、荨麻根、山金车、啤酒花、欧薄荷、百里香、水飞蓟属植物、玉米、牛蒡、石南花、正西番莲花、黑醋栗叶、齿叶乳香树、树皮、紫苜蓿、萝卜和金花菊、墨角藻属植物、海藻、榄仁树叶等。
发酵滤液
所述发酵滤液可选自酵母菌发酵产物滤液、乳酸杆菌发酵产物滤液、大米发酵滤液、二裂酵母发酵产物滤液等。
保湿剂
对保湿剂，本申请不作特别限定。可选地，所述保湿剂为无机保湿剂，如氯化钙。可选地，所述保湿剂为有机保湿剂，如多元醇、氨基酸和多糖。可选地，所述保湿剂为金属-有机保湿剂，如乳酸盐、葡萄糖酸盐。所述保湿剂可选自包括甘油、丙三醇、丙二醇、1,3-丁二醇、2,3-丁二醇、1,2-戊二醇、己二醇、双丙甘醇、甘油葡糖苷、山梨（糖）醇和山梨醇聚醚-20。酰胺类保湿剂、甘油聚醚类保湿剂、乳酸和乳酸钠、吡络烷酮羧酸钠、羟乙基脲、赤藓醇、甘油聚醚-5乳酸酯、透明质酸钠、糖类同分异构体、D-泛醇、聚乙二醇、双甘油、甲基丙烯酰氧乙基磷酸胆碱等。
螯合剂
对螯合剂，本发明不作特别限定。可选地，所述螯合剂选自乙二胺四乙酸及其钠盐、甘氨酸、柠檬酸、琥珀酸等。
润肤剂
对润肤剂，本申请不作特别限定。可选地，所述润肤剂为脂肪/油类、直链烷烃和蜡类，如矿脂、矿油、小麦芽胚油、纯地蜡、小麦芽胚油/小麦芽胚油甘油酯类、杏仁/桃仁油、椰子油、霍霍芭油、菜籽油/橄榄油/芝麻油、葵花油/玉米油/红花油。可选地，所述润肤剂为脂肪酸酯，如硬脂酸/棕榈酸/油酸乙二醇酯、PEG-5辛酸酯、PPG-36 油酸酯、鲸蜡硬脂醇乙基己酸酯、硬脂酸酯辛酯、己二酸二丁酯、鲸蜡硬脂醇异壬酸酯、肉豆蔻酸异丙酯、月桂酸异丙酯、棕榈酸异丙酯、羟基硬脂酸辛酯、硬脂酸异丙酯、椰油醇辛酸/癸酸酯、油酸癸酯、甘油聚醚-10月桂酸酯、甘油聚醚-10肉豆蔻酸酯、辛酸辛酯、油醇油酸酯、油醇芥酸酯、肉豆蔻醇肉豆蔻酸酯、月桂酸己酯。可选地，所述润肤剂为脂肪酸单酯和双酯、如甘油油酸酯、甘油月桂酸酯。可选地，所述润肤剂为乙氧基化甘油三酯，如PEG-6辛酸/癸酸甘油三酯、PEG-4辛酸/癸酸甘油三酯、PEG-45棕榈仁油甘油混合酯、PEG-60玉米油甘油混合酯、PEG-18棕榈油甘油混合酯、PEG-40杏仁油甘油混合酯、PEG-7橄榄油酸酯、羟基化牛奶甘油酯类。可选地，所述润肤剂为乙氧基化甘油单酯和双酯，如PEG-8甘油月桂酸酯、PEG-15甘油月桂酸酯、PEG-30甘油椰油酸酯、PEG-20甘油油酸酯、PEG-82甘油牛油脂酸酯、PEG-78甘油椰油酸酯、PEG-200甘油牛油脂酸酯。可选地，所述润肤剂为PPG-脂肪醇聚醚类润肤剂，如PPG-3月桂醇聚醚-5、PPG-5鲸蜡醇醚-20、PPG-8鲸蜡醇醚-20。可选地，所述润肤剂为PEG-n脂肪醇聚醚类润肤剂，如丁醇聚醚-14、月桂醇聚醚-4、硬脂醇聚醚-15、鲸蜡醇聚醚-60、二辛基环己烷、肉豆蔻醇聚醚-3、二辛基醚。可选地，所述润肤剂为脂肪醇类，如月桂醇、己基癸醇、油醇、辛基十二醇。
防腐剂
对防腐剂，本发明不作特别限定。优选地，防腐剂为对羟基苯乙酮、苯氧乙醇、氯苯甘醚。
着色剂
对着色剂，本发明不作特别限定。可选地，所述着色剂为焦糖色、水溶性黄色（例如CI 19140、CI 15985等）、水溶性红色（例如CI 16255、CI 14700等）本发明不作特别限定。CI（Color Index）代表色号。
pH调节剂
对pH调节剂，本发明不作特别限定。如乙酸盐、磷酸盐、柠檬酸盐、氢氧化钠、三乙醇胺、氨甲基丙醇、精氨酸、琥珀酸和碳酸盐等。
实施例
实施例1的配方如表1所示。
表1
实施例
实施例2的配方如表2所示。
表2
实施例
实施例3的配方如表3所示。
表3
实验部分
设置实验组1～5。其中：
根据本申请的技术方案制备实验组1～3，对照组为实验组4和实验组5。实验组4中聚二甲基硅氧烷与油的含量比大于60:1，实验组5中油与聚二甲基硅氧烷的含量比大于60:1，具体配方如表4所示。
表4
体系外观
制备完成后摇匀静置，观察实验组1～5的分层情况。
活性物的稳定性
分别检测在制备完成后，在温度为40℃的条件下静置30天后，在温度为40℃的条件下静置30天后各实验组中视黄醇的含量。结果如表5所示。
表5
从表5的结果中可以看出，实验组4和实验组5中聚二甲基硅氧烷或者，油的含量过高时，无法形成具有三层的料体外观（实验组5结果见图1）。除了外观不同，对于视黄醇的保护作用也明显低于具有三层的料体外观的实验组1～3（见图2），实验组4和实验组5在静置60天后视黄醇的保留率约为80%，而实验组1～3在在静置60天后，视黄醇的保留率至少达到96%以上。
基于本申请中的实施例，本领域普通技术人员在没有付出创造性劳动的前提下所获得的所有其他实施例，都属于本申请保护的范围。
本领域的普通技术人员，可以对上述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本申请各实施例技术方案的保护范围。
Claims (8)
1.一种组合物，其特征在于，其包括：
油，所述油与聚二甲基硅氧烷不互溶；所述油的密度小于聚二甲基硅氧烷；
聚二甲基硅氧烷；
水；
视黄醇和/或视黄醇衍生物；
所述油与聚二甲基硅氧烷的含量比或者，所述聚二甲基硅氧烷与油的含量比不高于60:1。
2.一种组合物，其特征在于，包括：
上层，所述上层包括油，所述油中包含视黄醇或视黄醇衍生物；
中间层，所述中间层为聚二甲基硅氧烷；
下层，所述下层为水层；
所述上层与中间层的含量比或者，所述中间层与上层的含量比不高于60:1。
3.如权利要求1或2所述组合物，其特征在于，所述油包括霍霍巴籽油、海檀木籽油、刺阿干树仁油、葡萄籽油、澳洲坚果籽油、甜肩桃油、向日葵籽油、全缘叶澳洲坚果籽油、鳄梨油、油橄榄果油、牡丹籽油、金盛花油、小麦胚芽油、澳洲蓝柏木油、白池花籽油、伯尔硬胡桃籽油、稻胚芽油、红木籽油、野大豆油、山茶籽油、玻璃苣籽油、印加果籽油、小果咖啡籽油、猴面包树籽油、沙棘果油、白花春黄菊花油、巴巴苏籽油、白兰花油、白叶腊菊花油、白千层油、白兰叶油、彼得松薄子木油、斑点老鹳草油、车前叶蓝蓟籽油、川谷籽油、草棉籽油、大果越桔籽油、川芎油、大裂叶五桤木籽油、稻糠油、滇山茶籽油、地中海柏木油、覆盆子籽油、海棠果籽油、广西沙柑果皮油、红莓苔子籽油、互生叶白千层叶油中的至少一种。
4.如权利要求1或2所述组合物，其特征在于，所述油的含量为0.5～70%。
5.如权利要求1或2所述组合物，其特征在于，所述聚二甲基硅氧烷的含量为0.5～20%。
6.如权利要求1或2所述组合物，其特征在于，所述视黄醇衍生物包括视黄醇棕榈酸酯、视黄醇丙酸酯、羟基频哪酮视黄酸酯、视黄醇视黄酸酯、视黄醇乙酸酯、视黄醇亚油酸酯中的至少一种。
7.如权利要求1或2所述组合物，其特征在于，所述视黄醇或视黄醇衍生物的含量为0.01～5%。
8.一种外用皮肤制剂，其特征在于，其包括如权利要求1～7任一所述的组合物。
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| CN117084944A (zh) * | 2023-10-18 | 2023-11-21 | 深圳市护家科技有限公司 | 皮肤调理剂组合物及其制备方法 |
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