CN1162665A

CN1162665A - Medical chitin fiber paper and making method therefor

Info

Publication number: CN1162665A
Application number: CN 96116322
Authority: CN
Inventors: 王建章
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-04-15
Filing date: 1996-04-15
Publication date: 1997-10-22

Abstract

A medical chitin fibre paper used as healing band, picking, dressing and bandage for wound features that the trial concentration of chitin is 1-10%, the ratio of chitin to LICL to DMAc is 1:(1-6):(100-800), the components of setting bath are DMAc and alcohol in weight ratio of 10-500:90-50, and after setting, the fibre is properly stretched by drawing ratio of 0.5-3 and washed by alcohol. It has the advantages of good sticking performance, multi-layer application, and high air permeability.

Description

Chitin medical fibre paper and manufacture method thereof

The manufacture method of the relevant a kind of medical chitin fiber of the present invention and chitin fiber paper mold wound patch and the wound dressing that makes by this fiber.

At present, the medically a large amount of traditional cotton yarn dressing that use of patient with operation, in use easily cause a skin inflammation, be used for sepage, oozing of blood more local time can cause hydrops, easily with bad phenomenon such as wound bonding, and regular the changing dressings of need, both increased the patient suffering, cause new wound more can for the wound in the healing, make wound healing slow, scar is big.So seeking the better medical dressing of result of use is the direction of making great efforts for present the world of medicine.

The crust prime system extensively is present in the natural polysaccharide high polymer of a kind of positively charged in free time, crab, insect shell and mushroom, the alga cells wall.At occurring in nature, the storage of chitin is only second to cellulose, has potential practical value and waits the natural resources developed again for a kind of.The chemical name of chitin is a chitin, the structure of its chemical constitution and native cellulose is close, chitin is to nontoxic, the non-stimulated allergic reaction of human body, has excellent biological compatibility with human body, no antibody response, and can be decomposed by the lysozyme in the human body and be absorbed by the body, other has unique medicinal properties such as anti-inflammatory, hemostasis, analgesia and the growth of promotion tissue.

At present the countries in the world solvent that is used to make the chitin spinning slurry has the mixture of trichloroacetic acid and chlorinated hydrocabon, the mixture of dichloroacetic acid and chlorinated hydrocabon, dimethylacetylamide (D M Ac) and lithium chloride mixed solvent, the mixed solvent of N-Methyl pyrrolidone (NMP) and lithium chloride etc.; In the document of having delivered, to adopt the first two kind solvent more.

Day disclosure special permission communique 57-16999 patent, a kind of manufacture method of chitin fiber paper is proposed, mixture multigelation with chitin and formic acid, add dichloroacetic acid then and be mixed with uniform spinning slurry, slurries are expressed in first coagulating bath of ethyl acetate, through methyl alcohol second coagulating bath, wash with ethanol at last.Its gained fibre single thread fiber number is 3.0 bags (are 3.3dte *), and intensity is 1.0g/d (be 0.89CM/DTE *).It is long that this sharp fiber is cut into about 5mm, copies paper according to common paper technology, and the quantitative of its gained paper is 65g/m, and burst factor is 1.11.

The objective of the invention is to propose a kind of employing DMAC-LICL or NMP-LICL is solvent, through wet spinning and the suitable technology that stretches, to produce the chitin fiber that meets the requirement of processing medico paper.The fiber number of this fiber is 0.56-11.1dte * i.e. (0.5-10d), dry strength 1.34-1.78CM/dte * i.e. (1.5-2.0g/d), and elongation 4-8% can develop the dressing of multi-purpose medical chitin fiber paper mold with this fiber papermaking.Adopt the chitin of DMAc-LICL or NMP-LICL preparation, its advantage of slurries is low to equipment corrosion, and the excellent stability of slurries, the slurries of preparation can be placed still normally spinning of time more than a year.

The chitin that the present invention is alleged also comprises chitosan (claiming shitosan, chitosan again), is the commercially available product that extracts the preparation gained from free time, crab shell.And, the main quality index of raw material chitin, as color and luster, moisture content, ash, viscosity, solubility property etc., the preparation of chitin slurries, the spinning of fiber and the quality of finished fiber there is close connection, so the present invention is moisture content≤10% to the requirement of raw material chitin quality index, ash≤0.3%, logarithmic viscosity number is at 4.5-5.5, and requires its favorable solubility; Chitin concentration (claiming concentration of slurry again) is generally 1-10% in the chitin slurries of this method preparation, and comparatively ideal concentration is 1-6%.

The process that the present invention makes chitin fiber paper is as follows:

With DMAc-LICL or NMP-LICL is solvent, in room temperature or be lower than that stirring and dissolving is mixed with the chitin spinning slurry after the regular hour under the temperature of room temperature.These slurries are handled the back with vacuum defoamation after filtration and are transported to the spinning cap with measuring pump, and spinning pulp spray silk liquid is expressed in the coagulating bath solidificating fiber from the cap hole.The spinning cap specification that is adopted is the 40-120 hole, and the aperture is 0.04-0.08mm, and the coagulating agent of coagulating bath can use acetone, methyl alcohol, ethanol etc. comparatively desirable.The concentration of coagulating agent is looked spinneret orifice what, factor such as spray silk velocity magnitude and adjusting in the coagulating bath, and general coagulating bath concentration is controlled at more than 50%, and temperature is at 100-300 ℃.For guaranteeing that fiber has sufficient intensity, in spinning process, must give suitable stretching, the multiple of stretching can be selected between 0.5-2 times.Fiber after solidifying is washes clean thoroughly, and the most handy absolute ethyl alcohol of Xian Di agent, clean chitin fiber directly are cut into the long staple fibre of 5mm, it is evenly dispersed in the water, copy paper according to conventional paper technology, and, make the medico paper of Different Weight and different size according to product needed.

As the chitin fiber of medical fibre paper material, must control its filament diameter and length within the specific limits, fiber is too thick, and interfibrous tack descends when copying paper; Fiber is oversize, and bad dispersibility in water all is unfavorable for copying paper, thus the fiber number of fiber should be controlled at 11.1dte * below, fibre length can not surpass 20mm.

The real process that the present invention makes chitin fiber paper is as follows:

Is viscosity 3 parts in the chitin powder (DMAc) of 1pas, inserts in the DMAc mixed solvent that contains 6%LICL, stirs three hours in the time of 20 ℃, makes transparent chitin spinning slurry.These slurries are filtered with 300 purpose stainless (steel) wires under the pressure of 0.4Mpa, then under vacuum, carry out deaeration.Chitin slurries after the filtration deaeration pass through measuring pump with the pressure of 0.2Mpa again, spinning cap specification is 100 holes, the aperture is 0.8mm, spinning is that 0.8ml/ changes with the metering pump size, spray volume with 14ml/min carries out spinning, spinning speed is controlled at about 15m/min, the DMAc mixed liquor that contains 70% absolute ethyl alcohol is adopted in coagulating bath, the chitin fiber of proposition coagulating bath continues with absolute ethanol washing and gives suitable stretching, the multiple that stretches is controlled between 0.5-2 times, through the chitin fiber filament number 2.5dtex that cleans, dry strength 1.5cN/dtex, extension at break are 7-8%.With being cut into the long staple fibre of 5mm behind the chitin fiber boundling, it is dispersed in the water uniformly, copy the paper method with routine and make chitin fiber paper.Cut into the paper of various different sizes again according to needed size, and stick on the elastic non-woven cloth base material that scribbles adhesive sticker, after making the medical or home-use wound applying dressing of various wound healing patches and undersized wound patch or different size, under the environment of N guarantees, pack in the packaging bag of being ready for, be finished product with routine disinfection again.

The chitin fiber paper mold wound dressing made from said method is compared with the medical dressing that the natural high polymer such as cotton fibre and various synthetic height are poly-, has following properties:

One, applying ointment or plaster property is good, can directly apply ointment or plaster at wound face, can be used as flap coverage, and is right Wound face has anti-inflammatory, hemostasis, pain relieving, promotes the effects such as wound tissue's growth, can impel Wound healing, even scar is disappeared.

Two, change dressings more during the treatment, but also multilayer repeats to apply ointment or plaster, and suffers to reduce Person's misery.

Three, good permeability, poisture-penetrability is good, does not have hydrops under dressing, and wound face is kept Drying, wound healing is fast.

Four, burn, scald, body surface are festered etc. significant curative effect is arranged, applicable to each doctor The postoperative patches such as the surgery of institute, plastic surgery; Also can use for military first aid, also Can be used as the standing medicine of family and whilst on tour.

Five, available conventional method sterilization, use and very convenient to carry.

Claims

1. the manufacture method of a chitin medical fibre paper, its characteristics are: chitin concentration is 1-10%, chitin: LICL: DMAc system is by 1: (1-6): (100-800) preparation, coagulating bath DMAc: the weight proportion of ethanol is (10-500): (90-50), and the fiber after solidifying gives suitable stretching.Draw ratio 0.5-3 doubly between, and fiber is clean with washing agent ethanol.

2. the manufacture method of chitin medical fibre paper according to claim 1, the filament number that it is characterized in that this fiber be 0.56-11.1 dte *, dry strength 1.34-1.78 CM/dtex, the elongation 4-8%.