CN1162476A - Ginseng and astragalus root powder for curing lead absorption of children and the preparation thereof - Google Patents
Ginseng and astragalus root powder for curing lead absorption of children and the preparation thereof Download PDFInfo
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- CN1162476A CN1162476A CN 97101356 CN97101356A CN1162476A CN 1162476 A CN1162476 A CN 1162476A CN 97101356 CN97101356 CN 97101356 CN 97101356 A CN97101356 A CN 97101356A CN 1162476 A CN1162476 A CN 1162476A
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Abstract
A powdered Chinese medicine for curing children's lead suction with high curative effect, low cost and no toxic by-effect is prepared from 12 Chinese-medicinal materials such as pilose asiabell root, astragalus root, tangerine peel, poria, kidney bean, etc.
Description
The present invention relates to a kind of ginseng and astragalus root powder and production method thereof that children's lead absorbs for the treatment of clinically.
Plumbous is hazardous trace elements to human body.Along with developing rapidly of traffic and industry, plumbous pollution to environment is on the rise, and lead and chemical compound thereof distribute in a large number in air, water source, soil and food, and enter human body by all means and health risk.Lead contamination causes general crowd's lead to be accumulated, and the control of Plumbum absorption has become international significant problem.For the child, because the factor of physiology, pathology has special susceptibility to lead contamination.Lead contamination can cause upgrowth and development of children slow, and mental retardation serious also can lead encephalopathy occur and causes irreversible dysnoesia etc.Children's lead absorbs, and shows as to press food, monophagia, hyperkinetic syndrome, often flu, on the low side, thin partially, zinc deficiency, rickets etc.Lead contamination has become a serious public health problem to child's harm.According to investigations,, send out amount to 3738 examples of lead content, account for 12.16% of sum,, be referred to as " Plumbum absorption for these clinical infants that does not reach the lead poisoning order of severity greater than 24.8 μ g/g to 30744 example statistics." at present for plumbous and receive the Western medicine that the treatment of infant is adopted; as chelating agent such as heavy metal complexing agent EDTA and DTPA, DME; also have penicillamine, obvious toxic and side effects is arranged, also have anaphylaxis; chelating agent class medicine particularly; also can cause kidney disease, but also, cause evil positive tool to be hindered; occurs obviously crossing the comprehensive disease of network etc., so western medicine " Plumbum absorption " can not make people's satisfaction because of non-selective chelating but take Western medicine.For this reason, adopt vitamin C or calcium preparation, vitamin B1 to treat at present, but effect is all undesirable.And China's Chinese materia medica is human treasure, and its treatment various diseases has one's own knack, be Western medicine can not than, so, can develop a kind of Chinese medicine and control child's " Plumbum absorption "?
Purpose of the present invention is exactly to provide a kind of ginseng and astragalus root powder and production method thereof that children's lead absorbs for the treatment of to the public.
The object of the present invention is achieved like this, according to Chinese medical theory, select for use Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Poria, Seem Lablab Album, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Folium Isatidis, Radix Glycyrrhizae, Fructus Hordei Germinatus, Pheretima 12 flavor Chinese medicines to form, its production method is that Chinese medicine processing is qualified in the compatibility weighing, elder generation's coarse powder is broken into graininess, spread then in Flat bottom container, place drying baker dry, temperature is suitable, through being ground into fine powder again, sieve, spread out straticulation again in flat chassis, radiation sterilization gets final product.
The present invention is made up of Chinese medicine, has no side effect, and abundant raw material, cost is low, good effect, its production method is simple, is easy to penetration and promotion, benefits the people.
Below in conjunction with embodiment the present invention is elaborated.
According to Chinese medical theory, selecting Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati for use is principal agent, has the effect of replenishing QI to invigorate the spleen gas; Be aided with Poria, Seem Lablab Album, have the ability of damp eliminating spleen invigorating; Strengthen the function of taste " fortuneization is received, ascending the clear and descending the turbid " jointly with principal agent; Pericarpium Citri Reticulatae is used to regulate the flow of vital energy, and makes QI invigorating and the non-stagnation of QI; Radix Angelicae Sinensis overweights enriches blood; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, " separating hundred poison "; Folium Isatidis contains the trace element of abundant needed by human body, and as Zn, Fe, Mn, it is precise and tiny to be used for replenishing the body desired nutritional; The Pheretima dredge the meridian passage, diuresis makes heresy go from urine; Fructus Hordei Germinatus help being good for the stomach stomach alive, help digestion and in.Medicine reasonable compatibility among above-mentioned, the effect that can play " spleen benefiting and stimulating the appetite, QI invigorating detoxifcation " altogether, hundred poison must be separated to make " in healthy energy deposits; heresy can not be done, ", thus clinical each symptom that harmful lead is caused is improved or eliminates, reach the purpose of treatment children's lead absorption, make children ' s healthy growth.
According to above-mentioned principle, through a large amount of practices, its all medicine compatibility is (by weight): 15 parts of Radix Codonopsis, 15 parts of the Radixs Astragali, 3 parts of Pericarpium Citri Reticulataes, 20 parts of Poria, 30 parts in Seem Lablab Album, 15 parts in Fructus Hordei Germinatus, 10 parts of Pheretimas, 6 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 6 parts of Folium Isatidiss, 20 parts of compositions of Radix Glycyrrhizae, as prepare 165 gram ginseng and astragalus root powders and can select Radix Codonopsis 15 grams, the Radix Astragali 150 grams, Pericarpium Citri Reticulatae 3 grams, Poria 20 grams, Seem Lablab Album 30 grams, Fructus Hordei Germinatus 15 grams, Pheretima 10 grams, Radix Angelicae Sinensis 6 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Rhizoma Polygonati 15 grams, Folium Isatidis 6 grams, Radix Glycyrrhizae 20 grams for use; As prepare 330 gram ginseng and astragalus root powders, can select Radix Codonopsis 30 grams, the Radix Astragali 30 grams, Pericarpium Citri Reticulatae 6 grams, Poria 40 grams, Seem Lablab Album 60 grams, Fructus Hordei Germinatus 30 grams, Pheretima 20 grams, Radix Angelicae Sinensis 12 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Rhizoma Polygonati 30 grams, Folium Isatidis 12 grams, Radix Glycyrrhizae 40 grams for use.If need the ginseng and astragalus root powder of other quantity of preparation, can be by the compatibility requirement, increase or minimizing respectively become deal to get final product.Ginseng and astragalus root powder is a powder, because of its principal agent is Radix Codonopsis and yellow formula, and is used for the treatment of children's lead and receipts again, so this medicine is called the ginseng and astragalus root powder that the treatment children's lead absorbs.
The production method of ginseng and astragalus root powder is by the compatibility requirement, to claim neat each composition dose, earlier draw shape with pulverizer coarse powder one-tenth, its size is about 3mm, spreads then in sugared porcelain dish of cleaning or stainless steel disc, thickness is no more than 5cm, places air dry oven, and forced air drying is more than 6 hours, temperature is controlled at 70-80 ℃, reach 100 order fine powders through three bavin field formula pulverizers pulverizing again, cross 100 mesh sieves, put difficult straticulation in the clean enamel tray then, ultraviolet rays radiation sterilization 0.5 hour, sealed packaging promptly.
Ginseng and astragalus root powder usage of the present invention is oral, every day three times, each 0.5 gram of following infant in June, 6 months to 1 years old each 1 gram of infant, 1 years old to 3 years old each 2 grams of infant, each 3 grams of infant more than 3 years old.Per two months is a course of treatment.
After tested, the mice that does test with medical science is an example, consequently: give mouse gavaging, show when ginseng and astragalus root powder can obviously reduce lead poisoning the lead content in the mice hair (P＜0.05); The reticuloendothelial system phagocytic function there is potentiation; The pair cell immunity has facilitation, and the obstacle model is consolidated in memory preventive and therapeutic effect, and nootropic effect is arranged.
Give the ginseng and astragalus root powder of mice with Cmax and heap(ed) capacity (maximum tolerated dose of administration is 45g/kg,, be equivalent to 150 times of clinical consumptions), and connect in the Yu Yiri to three times, Continuous Observation seven days, animal does not show any toxicity, none death shows that said preparation toxicity is low, and safety is big.
Ginseng and astragalus root powder was not seen toxic reaction in 120 days to the rat administration under 9g/kg dosage, drug withdrawal 15 days is also red sees that the retardance toxic reaction appears in animal, illustrates that ginseng and astragalus root powder has no side effect to rat, showed that said preparation takes safety non-toxic for a long time.
The clinical setting for the treatment of the children's lead absorption with the present invention is: with contrast treatment 400 examples relatively, its experimental group 300 examples, matched group 100 examples, 9 months of age minimum, maximum 11 years old, send out the minimum 24.9 μ g/g of lead content, the highest 121 μ g/g send out lead content totally 12 examples more than 80 μ g/g, simultaneously with 322 examples of sending out zinc＜100 μ g/g, with 163 examples of clinical symptoms 1-2 kind, 229 examples with the 3-4 kind, with 5 kinds 8 examples, what is called has several lead tolerance that are meant can be with anorexia greater than the infant of 24.8 μ g/g, monophagia, pica, hyperhidrosis, rest the head on bald, withered and yellowish hairs, often catch a cold pale complexion, hyperkinetic syndrome, on the low side, symptom such as thin partially.Its Therapeutic Method and result are the oral ginseng and astragalus root powder of experimental group infant, matched group infant oral vitamin C sheet, all requirements according to quantity, every day three times, be two months two groups of courses of treatment, the result is to treat 300 examples with ginseng and astragalus root powder, produce effects 227 examples, effective 53 examples, total effective rate is 93.3%, and VITAMIN C TABLET is treated 100 examples, produce effects 36 examples, effective 15 examples, total effective rate are that 61.0% ginseng and astragalus root powder obviously is better than vitamin C.Said produce effects, effective, the invalid HIGH DENSITY LIPOPROTEIN IN HEALTHY CHILDREN that is meant national regulation in 1991 send out appetite (to get infant hair 1 gram) plumbous and are no more than the standard of 24.8 μ g/g, serve as evaluation curative effect foundation to send out lead content and clinical symptom disappearance degree, specifically:
Produce effects: send out lead content＜24.8 μ g/g, the clinical symptoms complete obiteration;
Effectively: send out lead content＜24.8 μ g/g, clinical symptoms does not disappear; Or send out lead content decline＞10 μ g/g, but still more than 24.8 μ g/g, clinical symptoms takes a turn for the better or disappears;
Invalid: send out lead content decline＜10 μ g/g, but still descend more than 24.8 μ g/g or not, clinical symptoms does not have improvement.
Relevant curative effect details of the present invention can be referring to the clinical experimental research report of adnexa Zhengzhou City Children's Hospital.
In a word, scientific formulation of the present invention shows unique characteristics, obviously be better than the plumbous and receipts patient of existing western medicine, it is succeeded in developing and clinical practice is that one of Chinese materia medica is contributed greatly, has opened up the new way of treatment Plumbum absorption infant, must make creatively contribution for children ' s healthy growth.
Claims (2)
1, a kind of ginseng and astragalus root powder for the treatment of the children's lead absorption is characterized in that being made up of for 20 parts 15 parts of Radix Codonopsis, 15 parts of the Radixs Astragali, 3 parts of Pericarpium Citri Reticulataes, 20 parts of Poria, 30 parts in Seem Lablab Album, 15 parts in Fructus Hordei Germinatus, 10 parts of Pheretimas, 6 parts of Radix Angelicae Sinensis, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 6 parts of Folium Isatidiss, Radix Glycyrrhizae.
2, realize the production method of above-mentioned ginseng and astragalus root powder, it is characterized in that being, at first by the compatibility requirement, get Radix Codonopsis 15 grams that cook, the Radix Astragali 15 grams, Pericarpium Citri Reticulatae 3 grams, Poria 20 grams, Seem Lablab Album 30 grams, Fructus Hordei Germinatus 15 grams, Pheretima 10 grams, Radix Angelicae Sinensis 6 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Rhizoma Polygonati 15 grams, Folium Isatidis 6 grams, Radix Glycyrrhizae 20 grams, be ground into the graininess coarse powder of 3mm size earlier, spread again in dish, thickness is no more than 5cm, place air dry oven, dry more than 6 hours under 70-80 ℃ of temperature, powder essence becomes 100 order fine powders again, excessively behind 100 mesh sieves, sterilized 0.5 hour, sealed packaging promptly again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101356A CN1055005C (en) | 1997-01-30 | 1997-01-30 | Ginseng and astragalus root powder for curing lead absorption of children and the preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101356A CN1055005C (en) | 1997-01-30 | 1997-01-30 | Ginseng and astragalus root powder for curing lead absorption of children and the preparation thereof |
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| Publication Number | Publication Date |
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| CN1162476A true CN1162476A (en) | 1997-10-22 |
| CN1055005C CN1055005C (en) | 2000-08-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN97101356A Expired - Fee Related CN1055005C (en) | 1997-01-30 | 1997-01-30 | Ginseng and astragalus root powder for curing lead absorption of children and the preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086584C (en) * | 1998-07-13 | 2002-06-26 | 昆明冶金职业病防治中心 | Medicine for preventing chronic lead poisoning |
| CN102726721A (en) * | 2011-12-21 | 2012-10-17 | 聂存良 | Balanced trace element lead-removing oral liquid |
| CN103190506A (en) * | 2013-04-25 | 2013-07-10 | 北京绿源求证科技发展有限责任公司 | Food health tea electuary capable of promoting lead detoxification |
| CN103250841A (en) * | 2013-06-07 | 2013-08-21 | 北京绿源求证科技发展有限责任公司 | Food health protection tea electuary for promoting discharging of lead |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156031A (en) * | 1995-12-04 | 1997-08-06 | 南京臣功制药有限公司 | Oral medicine for dropping blood lead and its preparing method |
-
1997
- 1997-01-30 CN CN97101356A patent/CN1055005C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086584C (en) * | 1998-07-13 | 2002-06-26 | 昆明冶金职业病防治中心 | Medicine for preventing chronic lead poisoning |
| CN102726721A (en) * | 2011-12-21 | 2012-10-17 | 聂存良 | Balanced trace element lead-removing oral liquid |
| CN103190506A (en) * | 2013-04-25 | 2013-07-10 | 北京绿源求证科技发展有限责任公司 | Food health tea electuary capable of promoting lead detoxification |
| CN103250841A (en) * | 2013-06-07 | 2013-08-21 | 北京绿源求证科技发展有限责任公司 | Food health protection tea electuary for promoting discharging of lead |
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| Publication number | Publication date |
|---|---|
| CN1055005C (en) | 2000-08-02 |
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